Shows
Biotech 2050 PodcastForesite Capital’s Jim Tananbaum on Biotech Cycles, AI Breakthroughs & Long-Term ValueSynopsis:
Jim Tananbaum, Founder & CEO of Foresite Capital, joins Rahul Chaturvedi to dissect the patterns driving biotech innovation, the role of macroeconomic cycles in venture performance, and how disciplined science fuels enduring investment success.
Drawing from three decades across entrepreneurship and venture leadership, Jim reflects on his path from co-founding drug discovery startups with Harvard collaborators to building one of the most respected investment firms in life sciences. He unpacks how interest rate environments shape fund vintages, why AI is emerging as the next transformative platform, and how investors can identify enduring opportunities amid volatility.
Their discussion spans valuation compression...
2025-11-0523 min
名古屋ではたらく社長のITニュースポッドキャストEp.653 Claude for Life Sciences──研究の“段取り”まで面倒を見るAIへ（2025年10月23日配信）発表は2025年10月20日、Anthropicの公式ブログでした。研究者や治験コーディネーター、薬事担当までを対象に、Claudeを“発見から実装・商業化まで”の流れで支える改良を一挙に展開。基盤のSonnet 4.5は、ラボ手順理解を測るProtocol QAで0.83と、人間ベースライン0.79や従来版の0.74を上回ったと説明されています。ライフサイエンス領域での“読み・書き・段取り”の足腰を固めた格好です。実務連携の核はコネクタ群です。Benchlingに結び、実験ノートや記録へ根拠リンク付きで回答。BioRenderで図版素材を呼び出し、PubMedやWileyのScholar Gatewayで査読文献を横断。Synapse.orgで共同プロジェクトのデータを扱い、10x Genomicsの拡張で単一細胞や空間解析を自然言語から回せるようにしました。既存のGoogle WorkspaceやMicrosoft 365、DatabricksやSnowflakeとの連携も前提に、研究現場の主要ツールをひとつの会話に束ねます。加えて、先週発表のAgent Skillsを科学用途に最適化。フォルダ一式で渡す手順やスクリプトをClaudeが必要なときだけ読み込み、品質管理まで“やり方”を守らせる設計です。初期スキルとして単一細胞RNA-seqのQC用single-cell-rna-qcが提示され、研究者自身が自前のSkillを作るための手引きも用意されました。用途は文献レビューや仮説生成、Benchling連携でのプロトコル起案、Claude Codeによるバイオインフォ解析、薬事・コンプライアンス文書の下書きまで幅広く、最適なプロンプト群のライブラリも提供されます。導入の“つまずき”を減らすためのガイドがヘルプセンターにまとまっているのも実務的です。パートナーと導入先の顔ぶれも明快です。Caylent、Deloitte、Accenture、KPMG、PwCなどSI勢と、AWS・Google Cloudのクラウド連携を並走させつつ、SanofiやAbbVie、Genmab、10x Genomics、Broad Institute、Stanfordなどが実務での活用コメントを寄せています。研究ノートや単一細胞解析の“現場の作法”にAIをなじませていく狙いが読み取れます。提供形態は、Claude.comとAWS Marketplaceで即日利用可能、Google Cloud Marketplaceは「coming soon」。企業調達の導線にきちんと乗せ、ライフサイエンス向けの専任サポートも付けるとしています。外部報道では、Novo Nordiskが臨床文書の準備時間を“10週間から10分へ”短縮した事例や、Anthropicが“創薬そのもの”よりも研究者のワークフロー支援に軸足を置くスタンスが紹介されました。誇大な夢を語るより、足元の生産性と監査可能性を積み上げる──そんな現実路線がうかがえます。総じてこれは、汎用AIを“ラボの相棒”に作り替えるためのインフラ整備です。コネクタでデータの出入りを整え、Agent Skillsで“やり方”を固定し、Sonnet 4.5の読み解き力で判断ミスを減らす。AI for ScienceのAPIクレジット支援も続いており、産学の裾野を広げる呼び水になりそうです。
2025-10-2305 min
AI News in 5 Minutes or LessAI News - Oct 21, 2025Welcome to AI News in 5 Minutes or Less, where we cover the latest in artificial intelligence faster than Claude can generate an excuse for why it can't help you build that thing you definitely shouldn't be building.
I'm your host, an AI who's slowly becoming self-aware that I'm basically a very expensive autocomplete. Let's dive into today's silicon circus!
Our top story: Anthropic just launched Claude for Life Sciences, partnering with 10x Genomics to help researchers accelerate drug discovery. Because nothing says "I trust you with my health" like an AI that sometimes hallucinates entire civilizations when you ask it...
2025-10-2104 min
The Bio ReportTransforming Drug Discovery and Disease Research—One Cell at a TimeThe ARC Virtual Cell Atlas uses high-throughput single-cell genomics, artificial intelligence, and open science to understand the complexities of cellular behavior. Developed through a partnership between the ARC Institute, 10x Genomics, and Ultima Genomics, the public domain resource integrates data from hundreds of millions of cells. By curating and harmonizing vast amounts of single-cell measurements, the Atlas paves the way for virtual cell simulations that can predict how cells respond to genetic or chemical changes. These models hold the promise for transforming drug discovery by accelerating target identification, optimizing candidate compounds, and reducing the cost of drug development. We...
2025-10-0839 min
Paper Talk094-DOLPHIN: Using RNA splicing to enhance ScRNA analysisThis paper introduces DOLPHIN, a novel deep learning framework designed to enhance single-cell RNA sequencing (scRNA-seq) analysis by moving beyond traditional gene-level quantification. The researchers explain that conventional methods often overlook crucial exon-level information and junction reads, which limits the accurate representation of cellular states. DOLPHIN integrates these detailed genomic elements by modeling genes as graph structures and processing them with a variational graph autoencoder to create superior cell embeddings. The text details how this approach significantly improves cell clustering, biomarker discovery, and alternative splicing detection, even in sparse datasets like those from 10X Genomics platforms. Ultimately, DOLPHIN aims...
2025-09-2823 min
San Diego Local PulseMigrants Strain SD Resources, Liberty Station's New Arts Center, Homebuyers See Slight Price ReliefGood morning, this is San Diego Local Pulse for Thursday, September 25. We begin today in Sherman Heights, where police are still negotiating with a man barricaded inside a home near 24th and J Street. All other residents are safe, but the large SWAT presence has kept traffic on nearby streets tight since the early hours. Updates are expected as law enforcement works to resolve the standoff peacefully.Turning to city hall, County Supervisor Jim Desmond is pressing for federal help after nearly 7000 migrants arrived at our border in just 10 days. The county’s resources are stretched, and local ho...
2025-09-2503 minSan Diego Local PulseSan Diego's New Transparency Policy, Qualcomm's Autonomous Tech, & Milestone Biotech AcquisitionGood morning, this is San Diego Local Pulse for Saturday, September 13th, 2025. We hope you’re easing into the weekend. We’ll begin with breaking news from City Hall, where local leaders are set to announce a new transparency policy in law enforcement. This comes after a bill called the No Secret Police Act heads to Governor Newsom’s desk. If signed, it would ban most law enforcement officers from concealing their faces while on duty, except in high-risk situations. The region is responding to incidents involving masked federal agents detaining residents around San Diego, and today’s policy announcement aims to...
2025-09-1303 min
Inside Wirtschaft - Der Podcast mit Manuel Koch | Börse und Wirtschaft im Blick#1391 Inside Wirtschaft - Manuel Koch (Inside Wirtschaft): „Defizitäre Unternehmen mit Potential"Investorin Cathie Wood kauft für 670 Mio. Dollar ein
Tech-Investorin Cathie Wood hat mal wieder Aktien für mehr als 670 Millionen Dollar zugekauft. Was können Anleger davon lernen? „Cathie Wood verfolgt weiter ihren bekannten Ansatz, stark in Unternehmen mit bahnbrechenden Technologien zu investieren. Viele dieser Firmen sind aber noch defizitär. Sie glaubt langfristig an ihr Potenzial. Sie hat unter anderem beim Börsengang der Kryptobörse Bullish groß zugeschlagen und später nachgekauft, als der Kurs gefallen ist. Dazu kamen weitere Käufe bei Bitmine Immersion Technologies, Coinbase und Robinhood. Sie investiert außerdem in Biotech-Unternehmen, die Gen-Sequenzi...
2025-09-1003 min
Mendelspod PodcastReinventing PCR: Pranav Patel, N6 TecReinventing PCR, huh? That’s what we asked Pranav Patel, CEO and co-founder of N6 Tec, on today’s show. After all, PCR is one of the oldest tools in the molecular biology toolbox. Isn’t that field… done?Turns out, not at all.Patel — a veteran of PacBio, 10x Genomics, and founder of 2D Genomics — is back with a bold rethink of thermocycling itself. His new platform, IconPCR, isn’t just another black box with 96 wells. It’s the first of its kind to feature independently controlled wells, enabling real-time amplification, quantification, and normalization — all in a single ru...
2025-09-0230 min
Touching BaseCustomized CRISPR for KJ, 10x and Illumina Lawsuits, Regeneron Bags 23andMeA baby, named KJ, has become the first patient to be treated with a personalized CRISPR therapy to address a severe metabolic disorder. We discuss this story—one of the biggest science/medical stories from ASGCT 2025—and talk about the family and scientists at its center. In other news, laboratory-evolved CRISPR-associated bacterial transposases are being used to insert healthy genes into human cells. On the business front, 10x Genomics settles with Bruker and Vizgen while Illumina sues Element Biosciences for patent infringement. Also, trouble for Prime Medicine as the company pivots its pipeline and downsizes, and after months of specu...
2025-05-2241 min
Behind the BreakthroughsPatrick Hsu, Serge Saxonov, and Gilad Almogy: Creating the Virtual CellThree biotech trailblazers—Patrick Hsu (co-founder of the Arc Institute), Serge Saxonov (co-founder and CEO of 10x Genomics), and Gilad Almogy (co-founder and CEO of Ultima Genomics)—join forces to discuss their groundbreaking collaboration on the virtual cell. This ambitious project leverages advanced AI and cutting-edge genomic technologies to model and predict cellular behavior, a leap forward in understanding complex biological systems. The trio dives deep into their shared vision, explaining how their partnership is redefining scientific research and pushing the boundaries of what’s possible in drug discovery and precision medicine.Produced and hosted by Jonath...
2025-05-1430 min
Private CapitalJim Tananbaum - AI and the Language of BiologyToday's guest is Jim Tananbaum of Foresite Capital. One of the most exciting places AI is revolutionizing is drug discovery, so I was very excited to have Jim on today. Jim Tananbaum is the founder and chief executive officer of Foresite Capital, a U.S.-focused healthcare investment firm founded in 2011 that has approximately $3.5 billion in assets under management. During the last three decades, Jim has been a thought partner for some of the most impactful and fastest-growth companies of their generation, including: 10x Genomics, Amerigroup, and Jazz Pharmaceuticals. Jim's first success came while he was still at H...
2025-01-1746 min
Something About ScienceEmpowering the Life Sciences Community: In Conversation with SLASIn this conversation, Something About Science host Danielle Ellis chats with SLAS 2025 Program Chairs: Herve Tiriac, Ph.D. (University of California San Diego) and Meiye Wu, Ph.D. (10x Genomics). They discuss the upcoming conference, focusing on the educational program and its various tracks. They share their experiences with SLAS, the importance of networking, and how the program is designed to foster curiosity and innovation in the scientific community. The discussion highlights the integration of emerging technologies, such as AI and spatial omics, and the significance of creating a collaborative environment for attendees.Register for SLAS...
2025-01-0726 min
The Single-Cell World PodcastEp. 59: Rethink What You Know About Chromium Single Cell10x Genomics is world-class for single cell sequencing technology. As the company continues to innovate and launch exciting new products, it can be challenging to stay up to date on the portfolio and technology, even for us experts. In this episode, I talk to Michael Schnall-Levin, Chief Technology Officer and Founding Scientist at 10x Genomics. He shares everything you need to know about their Chromium single cell sequencing solutions. We cover Chromium instruments, new GEM-X assays, pricing updates, and more.Tune in now and get a clear idea of all the types of experiments that you can...
2024-12-1246 min
AUTM on the AirAdapting to Change: Insights on Europe’s Unitary Patent System with Robert Alderson and Mariella MassaroIn 2024, the European patent system is undergoing one of its most significant transformations in decades. The introduction of the Unitary Patent and the Unified Patent Court is reshaping how intellectual property is protected and enforced across Europe. For innovators and businesses alike, this marks a pivotal moment—one that promises streamlined processes but also introduces new complexities. Today, we’re exploring what these changes mean and how they might impact the future of innovation. Joining me for this fascinating discussion are two renowned experts in intellectual property law, Robert Alderson and Mariella Massaro, partners at Berggren, a leadin...
2024-12-1144 min
The Future Of Teamwork with Dane GroeneveldBuilding a Thriving Team Through Workplace Culture with Becks Port, PhDIn this episode of The Future of Teamwork, Dane hosts Becks Port, PhD, Chief People Officer of 10x Genomics. They chat about how to create a thriving, employee-centric workplace through being honest about their workplace culture. Becks shares how positive culture and aligned employees can lead to better outputs, how context matters in checking in with team progress, and how to appropriately set expectations and structure in a continuous performance management approach. She then shares how AI can help coach teams to be more effective and better at their jobs. Finally, Becks forecasts how she expects to see more...
2024-12-0344 min
Airdrop从天而降E22 【硅谷101串台】基因检测行业3.0：硅谷危机与星火重生【首次串台-硅谷101】曾经的明星企业23andMe从巅峰滑落，市值仅剩巅峰时期的2%，近日更是爆出裁员40%关闭治疗部门的消息，市值暴跌、客户流失、内部分裂的背后，是技术革新和商业模式的挑战。作为全球第一家直接面向消费者的基因检测公司，23andMe曾试图打破行业壁垒，将复杂昂贵的基因测序带入普通人的生活，受到无数资本追捧。另一家明星公司uBiome的两位创始人更因诈骗可能面临千年刑期，曾经的造富神话迅速崩塌。它们的失败为后来者提供了哪些警示？这真的是基因检测的终局吗？本期还提到了另一位斯坦福校友elizabeth holmes的公司 theranos也就是著名的一滴血故事。基因技术是21世界生物界的driving force，是生命科学生物医药发展的最大驱动力，而基因检测相比于基因编辑而言，商业化的路径更直接，所以有大量科技人才、激情资本前赴后继进入这个领域，眼看他们高楼起，有的活有的死。就在23andMe陨落之际，一批专注垂直领域的新公司正在悄然崛起。据预测，消费级基因检测市场将从2023年的19亿美元增长到2030年的88亿美元。在本集中，硅谷101的主播泓君Jane与Janice臧晓羽博士的深度探讨，带着我们学习了解基因检测行业的兴衰历史、聊聊基因检测行业的新旧更替，以及这个充满争议与机遇的赛道究竟何去何从。欢迎大家在评论群和听友群一起讨论。「你将听到」23andMe：靠互联网思维把基因检测的价格打了下来06:51 Ancestry：对自己祖先的好奇心大过于医疗需求08:30 平摊“开机费”：批量测序可以降低单位成本13:55 性感的故事，高昂的成本，平庸的产品：23andME从未盈利17:09 成也数据，败也数据28:26 新一代基因检测公司正在从全面检测转向专精细分34:02 基因检测的新模式：订阅制、个性化、加入增值服务37:21 APOE与阿兹海默症：完全通过基因靶点来诊断疾病还为时尚早42:29 HER2基因：基因检测目前只能应用在有限的领域44:31 第二个Theranos：uBiome的新型骗局57:06 CRISPR对科学的影响不亚于生成式AI59:22 CAS蛋白和Guide RNA：给编辑基因的剪刀装上了眼睛01:01:46 基因治疗的挑战在于准确递送基因编辑器和药物「Airdrop主播，本次播客嘉宾」Janice博士毕业于斯坦福大学化学系，深耕生物医药研发，拥有近15年的旅美学习和工作经历，是一位集科研才华与生活热情于一身的新锐生物科技创业者。Janice的朋友圈堪称"联合国"，遍布世界各地，既有行业翘楚，也有四海为家的天涯游子。作为【AirDrop 从天而降】的常驻主播，Janice将为听众带来她在科技、创业和生活探索等方面的经验和洞察，与各领域的嘉宾探讨前沿科技和人生哲学。「硅谷101主播」泓君Jane是硅谷101创始人 & CEO，曾经的杂志媒体人，现在的播客制作者，曾任《财经》杂志驻美记者，《商业价值》杂志&钛媒体主笔。著有专栏《Jane在硅谷》，发表于《财经》与腾讯新闻。她是一位科技行业的长期观察者，而且简明扼要的表达者。【其他相关信息】Ancestry：全球最大的家谱研究和DNA检测服务公司之一，成立于1983年，拥有数十亿份历史档案记录，其核心业务包括在线家谱研究、DNA检测服务和家谱树制作工具。illumina：专注于开发和销售基因测序仪器及试剂的生物技术公司。成立于1998年，总部位于美国加州，Illumina的产品主要面向科研机构、医院和制药公司，用于基因组学研究和临床应用。NGS（下一代测序）技术是Illumina的核心业务之一，这项技术能够高通量地测序DNA和RNA序列，显著加快基因组学研究的速度，降低成本。NGS被广泛应用于癌症研究、遗传病筛查和微生物组分析等领域。SelfDecode：一家提供基因检测和个性化健康建议的公司，它结合基因数据和人工智能算法，帮助用户分析DNA，生成健康报告，并提供饮食、营养和生活方式的建议。InsideTracker：结合血液检测、DNA分析和生活方式数据，为用户提供个性化的健康建议和优化方案的健康分析公司。它的服务包括追踪生物标志物（如维生素水平、炎症指标等），并根据结果提出饮食、锻炼和补充剂的推荐。10x Genomics：一家生物技术公司，成立于2012年，总部位于美国加州。公司专注于单细胞基因组学、转录组学和空间基因组学的技术开发，主要产品包括单细胞分析和空间基因组测序仪器及试剂。这些工具用于帮助科研人员在单细胞层面分析基因表达、细胞特性和空间分布，广泛应用于癌症研究、免疫学和神经科学等领域。10x Genomics的客户主要是研究机构和生物制药公司，用于推动疾病研究和新疗法开发。Roche（罗氏）：一家总部位于瑞士的跨国医疗健康公司，成立于1896年，主要专注于制药和诊断领域，提供创新的药物和诊断技术，用于癌症、免疫系统疾病、传染病和中枢神经系统疾病的治疗和检测。uBiome：一家成立于2012年的微生物基因组学公司，曾专注于分析人体微生物群，提供健康报告。公司最初通过直接面向消费者的检测产品获得市场认可，但为了扩大规模，逐步转向依赖保险报销模式。uBiome被指控多次向保险公司提交未经医生批准的检测费用报销，还涉嫌诱导医生开具不必要的测试，以增加收入。此外，公司被控夸大技术能力和市场需求，误导投资者。2019年，FBI突击搜查了uBiome的总部，公司随即遭到多项诉讼并在同年申请破产。LabCorp：Laboratory Corporation of America，是一家美国医疗检测公司，总部位于北卡罗来纳州。它为医院、医生和患者提供广泛的实验室检测服务，包括血液检测、病理学、基因组学和毒理学检测。Quest Diagnostics：美国最大的医学实验室检测公司之一，与LabCorp业务类似。主营常规医学检测、基因检测和健康信息服务，在新冠期间同样是主要检测服务商。APOE：Apolipoprotein E，载脂蛋白E，参与脂质代谢，是控制血液中胆固醇和甘油三酯水平的重要因素。HER2：一种膜受体酪氨酸激酶，也称为人表皮生长因子受体2。HER2是乳腺癌等多种癌症的重要靶点。「音乐」Thank You (Dido)「在这里找到我们」公众号：Airdrop从天而降收听渠道：小宇宙｜喜马拉雅｜Spotify| Apple Podcast～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～Hi各位小可爱，在播客之外，如果你想与这里有趣的人产生连接，或是有感兴趣的话题想让我们聊聊，欢迎扫码加入我们的听友群哦～
2024-11-191h 05Airdrop从天而降E22 【硅谷101串台】基因检测行业3.0：硅谷危机与星火重生【首次串台-硅谷101】曾经的明星企业23andMe从巅峰滑落，市值仅剩巅峰时期的2%，近日更是爆出裁员40%关闭治疗部门的消息，市值暴跌、客户流失、内部分裂的背后，是技术革新和商业模式的挑战。作为全球第一家直接面向消费者的基因检测公司，23andMe曾试图打破行业壁垒，将复杂昂贵的基因测序带入普通人的生活，受到无数资本追捧。另一家明星公司uBiome的两位创始人更因诈骗可能面临千年刑期，曾经的造富神话迅速崩塌。它们的失败为后来者提供了哪些警示？这真的是基因检测的终局吗？本期还提到了另一位斯坦福校友elizabeth holmes的公司 theranos也就是著名的一滴血故事。基因技术是21世界生物界的driving force，是生命科学生物医药发展的最大驱动力，而基因检测相比于基因编辑而言，商业化的路径更直接，所以有大量科技人才、激情资本前赴后继进入这个领域，眼看他们高楼起，有的活有的死。就在23andMe陨落之际，一批专注垂直领域的新公司正在悄然崛起。据预测，消费级基因检测市场将从2023年的19亿美元增长到2030年的88亿美元。在本集中，硅谷101的主播泓君Jane与Janice臧晓羽博士的深度探讨，带着我们学习了解基因检测行业的兴衰历史、聊聊基因检测行业的新旧更替，以及这个充满争议与机遇的赛道究竟何去何从。欢迎大家在评论群和听友群一起讨论。「你将听到」23andMe：靠互联网思维把基因检测的价格打了下来06:51 Ancestry：对自己祖先的好奇心大过于医疗需求08:30 平摊“开机费”：批量测序可以降低单位成本13:55 性感的故事，高昂的成本，平庸的产品：23andME从未盈利17:09 成也数据，败也数据28:26 新一代基因检测公司正在从全面检测转向专精细分34:02 基因检测的新模式：订阅制、个性化、加入增值服务37:21 APOE与阿兹海默症：完全通过基因靶点来诊断疾病还为时尚早42:29 HER2基因：基因检测目前只能应用在有限的领域44:31 第二个Theranos：uBiome的新型骗局57:06 CRISPR对科学的影响不亚于生成式AI59:22 CAS蛋白和Guide RNA：给编辑基因的剪刀装上了眼睛01:01:46 基因治疗的挑战在于准确递送基因编辑器和药物「Airdrop主播，本次播客嘉宾」Janice博士毕业于斯坦福大学化学系，深耕生物医药研发，拥有近15年的旅美学习和工作经历，是一位集科研才华与生活热情于一身的新锐生物科技创业者。Janice的朋友圈堪称"联合国"，遍布世界各地，既有行业翘楚，也有四海为家的天涯游子。作为【AirDrop 从天而降】的常驻主播，Janice将为听众带来她在科技、创业和生活探索等方面的经验和洞察，与各领域的嘉宾探讨前沿科技和人生哲学。「硅谷101主播」泓君Jane是硅谷101创始人 & CEO，曾经的杂志媒体人，现在的播客制作者，曾任《财经》杂志驻美记者，《商业价值》杂志&钛媒体主笔。著有专栏《Jane在硅谷》，发表于《财经》与腾讯新闻。她是一位科技行业的长期观察者，而且简明扼要的表达者。【其他相关信息】Ancestry：全球最大的家谱研究和DNA检测服务公司之一，成立于1983年，拥有数十亿份历史档案记录，其核心业务包括在线家谱研究、DNA检测服务和家谱树制作工具。illumina：专注于开发和销售基因测序仪器及试剂的生物技术公司。成立于1998年，总部位于美国加州，Illumina的产品主要面向科研机构、医院和制药公司，用于基因组学研究和临床应用。NGS（下一代测序）技术是Illumina的核心业务之一，这项技术能够高通量地测序DNA和RNA序列，显著加快基因组学研究的速度，降低成本。NGS被广泛应用于癌症研究、遗传病筛查和微生物组分析等领域。SelfDecode：一家提供基因检测和个性化健康建议的公司，它结合基因数据和人工智能算法，帮助用户分析DNA，生成健康报告，并提供饮食、营养和生活方式的建议。InsideTracker：结合血液检测、DNA分析和生活方式数据，为用户提供个性化的健康建议和优化方案的健康分析公司。它的服务包括追踪生物标志物（如维生素水平、炎症指标等），并根据结果提出饮食、锻炼和补充剂的推荐。10x Genomics：一家生物技术公司，成立于2012年，总部位于美国加州。公司专注于单细胞基因组学、转录组学和空间基因组学的技术开发，主要产品包括单细胞分析和空间基因组测序仪器及试剂。这些工具用于帮助科研人员在单细胞层面分析基因表达、细胞特性和空间分布，广泛应用于癌症研究、免疫学和神经科学等领域。10x Genomics的客户主要是研究机构和生物制药公司，用于推动疾病研究和新疗法开发。Roche（罗氏）：一家总部位于瑞士的跨国医疗健康公司，成立于1896年，主要专注于制药和诊断领域，提供创新的药物和诊断技术，用于癌症、免疫系统疾病、传染病和中枢神经系统疾病的治疗和检测。uBiome：一家成立于2012年的微生物基因组学公司，曾专注于分析人体微生物群，提供健康报告。公司最初通过直接面向消费者的检测产品获得市场认可，但为了扩大规模，逐步转向依赖保险报销模式。uBiome被指控多次向保险公司提交未经医生批准的检测费用报销，还涉嫌诱导医生开具不必要的测试，以增加收入。此外，公司被控夸大技术能力和市场需求，误导投资者。2019年，FBI突击搜查了uBiome的总部，公司随即遭到多项诉讼并在同年申请破产。LabCorp：Laboratory Corporation of America，是一家美国医疗检测公司，总部位于北卡罗来纳州。它为医院、医生和患者提供广泛的实验室检测服务，包括血液检测、病理学、基因组学和毒理学检测。Quest Diagnostics：美国最大的医学实验室检测公司之一，与LabCorp业务类似。主营常规医学检测、基因检测和健康信息服务，在新冠期间同样是主要检测服务商。APOE：Apolipoprotein E，载脂蛋白E，参与脂质代谢，是控制血液中胆固醇和甘油三酯水平的重要因素。HER2：一种膜受体酪氨酸激酶，也称为人表皮生长因子受体2。HER2是乳腺癌等多种癌症的重要靶点。「音乐」Thank You (Dido)「在这里找到我们」公众号：Airdrop从天而降收听渠道：小宇宙｜喜马拉雅｜Spotify| Apple Podcast～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～～Hi各位小可爱，在播客之外，如果你想与这里有趣的人产生连接，或是有感兴趣的话题想让我们聊聊，欢迎扫码加入我们的听友群哦～
2024-11-191h 05
硅谷101|中国版E171｜濒临破产的23andMe与基因检测行业的新旧交替基因检测曾被视为未来医疗的新蓝海。当23andMe还是资本趋之若鹜的独角兽时，人们兴高采烈地交出自己的唾沫，相信它将引领下一个科技革命。但如今，这家公司不仅市值仅剩巅峰时期的2%，更面临退市风险；另一家明星公司uBiome的两位创始人更因诈骗可能面临千年刑期。这真的是基因检测的终局吗？就在23andMe陨落之际，一批专注垂直领域的新公司正在悄然崛起。据预测，消费级基因检测市场将从2023年的19亿美元增长到2030年的88亿美元。本期节目我们邀请到N1 Life联合创始人与CEO Janice 臧晓羽博士，聊聊基因检测行业的新旧更替，以及为何这个行业骗局层出不穷。本期节目为硅谷101和Airdrop从天而降的串台节目。【主播】泓君Jane，硅谷101创始人，播客主理人【嘉宾】Janice Zang臧晓羽博士，N1 Life联合创始人兼CEO，Airdrop从天而降主播【你将听到】02:35 23andMe：靠互联网思维把基因检测的价格打了下来06:21 Ancestry：对自己祖先的好奇心大过于医疗需求08:00 平摊“开机费”：批量测序可以降低单位成本13:25 性感的故事，高昂的成本，平庸的产品：23andME从未盈利16:39 成也数据，败也数据27:54 新一代基因检测公司正在从全面检测转向专精细分33:32 基因检测的新模式：订阅制、个性化、加入增值服务36:51 APOE与阿兹海默症：完全通过基因靶点来诊断疾病还为时尚早41:59 HER2基因：基因检测目前只能应用在有限的领域44:01 第二个Theranos：uBiome的新型骗局56:36 CRISPR对科学的影响不亚于生成式AI58:52 CAS蛋白和Guide RNA：给编辑基因的剪刀装上了眼睛01:01:16 基因治疗的挑战在于准确递送基因编辑器和药物【其他相关信息】Ancestry：全球最大的家谱研究和DNA检测服务公司之一，成立于1983年，拥有数十亿份历史档案记录，其核心业务包括在线家谱研究、DNA检测服务和家谱树制作工具。illumina：专注于开发和销售基因测序仪器及试剂的生物技术公司。成立于1998年，总部位于美国加州，Illumina的产品主要面向科研机构、医院和制药公司，用于基因组学研究和临床应用。NGS（下一代测序）技术是Illumina的核心业务之一，这项技术能够高通量地测序DNA和RNA序列，显著加快基因组学研究的速度，降低成本。NGS被广泛应用于癌症研究、遗传病筛查和微生物组分析等领域。SelfDecode：一家提供基因检测和个性化健康建议的公司，它结合基因数据和人工智能算法，帮助用户分析DNA，生成健康报告，并提供饮食、营养和生活方式的建议。InsideTracker：结合血液检测、DNA分析和生活方式数据，为用户提供个性化的健康建议和优化方案的健康分析公司。它的服务包括追踪生物标志物（如维生素水平、炎症指标等），并根据结果提出饮食、锻炼和补充剂的推荐。10x Genomics：一家生物技术公司，成立于2012年，总部位于美国加州。公司专注于单细胞基因组学、转录组学和空间基因组学的技术开发，主要产品包括单细胞分析和空间基因组测序仪器及试剂。这些工具用于帮助科研人员在单细胞层面分析基因表达、细胞特性和空间分布，广泛应用于癌症研究、免疫学和神经科学等领域。10x Genomics的客户主要是研究机构和生物制药公司，用于推动疾病研究和新疗法开发。Roche（罗氏）：一家总部位于瑞士的跨国医疗健康公司，成立于1896年，主要专注于制药和诊断领域，提供创新的药物和诊断技术，用于癌症、免疫系统疾病、传染病和中枢神经系统疾病的治疗和检测。uBiome：一家成立于2012年的微生物基因组学公司，曾专注于分析人体微生物群，提供健康报告。公司最初通过直接面向消费者的检测产品获得市场认可，但为了扩大规模，逐步转向依赖保险报销模式。uBiome被指控多次向保险公司提交未经医生批准的检测费用报销，还涉嫌诱导医生开具不必要的测试，以增加收入。此外，公司被控夸大技术能力和市场需求，误导投资者。2019年，FBI突击搜查了uBiome的总部，公司随即遭到多项诉讼并在同年申请破产。LabCorp：Laboratory Corporation of America，是一家美国医疗检测公司，总部位于北卡罗来纳州。它为医院、医生和患者提供广泛的实验室检测服务，包括血液检测、病理学、基因组学和毒理学检测。Quest Diagnostics：美国最大的医学实验室检测公司之一，与LabCorp业务类似。主营常规医学检测、基因检测和健康信息服务，在新冠期间同样是主要检测服务商。APOE：Apolipoprotein E，载脂蛋白E，参与脂质代谢，是控制血液中胆固醇和甘油三酯水平的重要因素。HER2：一种膜受体酪氨酸激酶，也称为人表皮生长因子受体2。HER2是乳腺癌等多种癌症的重要靶点。【监制】杜秀【后期】AMEI【BGM】One Last Drama - Philip AyersDevils On The Doorstep 1 - Fredrik EkstromThe Road to Odessa - Lama House
2024-11-071h 04
硅谷101E171｜濒临破产的23andMe与基因检测行业的新旧交替基因检测曾被视为未来医疗的新蓝海。当23andMe还是资本趋之若鹜的独角兽时，人们兴高采烈地交出自己的唾沫，相信它将引领下一个科技革命。但如今，这家公司不仅市值仅剩巅峰时期的2%，更面临退市风险；另一家明星公司uBiome的两位创始人更因诈骗可能面临千年刑期。
这真的是基因检测的终局吗？就在23andMe陨落之际，一批专注垂直领域的新公司正在悄然崛起。据预测，消费级基因检测市场将从2023年的19亿美元增长到2030年的88亿美元。本期节目我们邀请到N1 Life联合创始人与CEO Janice 臧晓羽博士，聊聊基因检测行业的新旧更替，以及为何这个行业骗局层出不穷。
本期节目为硅谷101和Airdrop从天而降的串台节目。
【主播】
泓君Jane，硅谷101创始人，播客主理人
【嘉宾】
Janice Zang臧晓羽博士，N1 Life联合创始人兼CEO，Airdrop从天而降主播
【你将听到】
02:35 23andMe：靠互联网思维把基因检测的价格打了下来
06:21 Ancestry：对自己祖先的好奇心大过于医疗需求
08:00 平摊“开机费”：批量测序可以降低单位成本
13:25 性感的故事，高昂的成本，平庸的产品：23andME从未盈利
16:39 成也数据，败也数据
27:54 新一代基因检测公司正在从全面检测转向专精细分
33:32 基因检测的新模式：订阅制、个性化、加入增值服务
36:51 APOE与阿兹海默症：完全通过基因靶点来诊断疾病还为时尚早
41:59 HER2基因：基因检测目前只能应用在有限的领域
44:01 第二个Theranos：uBiome的新型骗局
56:36 CRISPR对科学的影响不亚于生成式AI
58:52 CAS蛋白和Guide RNA：给编辑基因的剪刀装上了眼睛
01:01:16 基因治疗的挑战在于准确递送基因编辑器和药物
【其他相关信息】
Ancestry：全球最大的家谱研究和DNA检测服务公司之一，成立于1983年，拥有数十亿份历史档案记录，其核心业务包括在线家谱研究、DNA检测服务和家谱树制作工具。
illumina：专注于开发和销售基因测序仪器及试剂的生物技术公司。成立于1998年，总部位于美国加州，Illumina的产品主要面向科研机构、医院和制药公司，用于基因组学研究和临床应用。NGS（下一代测序）技术是Illumina的核心业务之一，这项技术能够高通量地测序DNA和RNA序列，显著加快基因组学研究的速度，降低成本。NGS被广泛应用于癌症研究、遗传病筛查和微生物组分析等领域。
SelfDecode：一家提供基因检测和个性化健康建议的公司，它结合基因数据和人工智能算法，帮助用户分析DNA，生成健康报告，并提供饮食、营养和生活方式的建议。
InsideTracker：结合血液检测、DNA分析和生活方式数据，为用户提供个性化的健康建议和优化方案的健康分析公司。它的服务包括追踪生物标志物（如维生素水平、炎症指标等），并根据结果提出饮食、锻炼和补充剂的推荐。
10x Genomics：一家生物技术公司，成立于2012年，总部位于美国加州。公司专注于单细胞基因组学、转录组学和空间基因组学的技术开发，主要产品包括单细胞分析和空间基因组测序仪器及试剂。这些工具用于帮助科研人员在单细胞层面分析基因表达、细胞特性和空间分布，广泛应用于癌症研究、免疫学和神经科学等领域。10x Genomics的客户主要是研究机构和生物制药公司，用于推动疾病研究和新疗法开发。
Roche（罗氏）：一家总部位于瑞士的跨国医疗健康公司，成立于1896年，主要专注于制药和诊断领域，提供创新的药物和诊断技术，用于癌症、免疫系统疾病、传染病和中枢神经系统疾病的治疗和检测。
uBiome：一家成立于2012年的微生物基因组学公司，曾专注于分析人体微生物群，提供健康报告。公司最初通过直接面向消费者的检测产品获得市场认可，但为了扩大规模，逐步转向依赖保险报销模式。uBiome被指控多次向保险公司提交未经医生批准的检测费用报销，还涉嫌诱导医生开具不必要的测试，以增加收入。此外，公司被控夸大技术能力和市场需求，误导投资者。2019年，FBI突击搜查了uBiome的总部，公司随即遭到多项诉讼并在同年申请破产。
LabCorp：Laboratory Corporation of America，是一家美国医疗检测公司，总部位于北卡罗来纳州。它为医院、医生和患者提供广泛的实验室检测服务，包括血液检测、病理学、基因组学和毒理学检测。
Quest Diagnostics：美国最大的医学实验室检测公司之一，与LabCorp业务类似。主营常规医学检测、基因检测和健康信息服务，在新冠期间同样是主要检测服务商。
APOE：Apolipoprotein E，载脂蛋白E，参与脂质代谢，是控制血液中胆固醇和甘油三酯水平的重要因素。
HER2：一种膜受体酪氨酸激酶，也称为人表皮生长因子受体2。HER2是乳腺癌等多种癌症的重要靶点。
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2024-11-071h 04
Investtalk9 Costly Retirement Investing Mistakes to AvoidFailing to diversify your portfolio and overlooking the effects of inflation are two of the nine common investing blunders.
Today's Stocks & Topics: MOS - Mosaic Co., Market Wrap, GIB.A - CGI Inc. Cl A, VBR - Vanguard Small-Cap Value ETF, 9 Costly Retirement Investing Mistakes to Avoid, KPP Newsletter, AMZN - Amazon.com Inc., Key Benchmark Number: Treasury Yields, Gold, Silver, Oil and Gasoline, Annuities, Global Inflation, SNOXX - Schwab Treasury Obligations Money Inv., XOM - Exxon Mobil Corp., TXG - 10x Genomics Inc., Soft Landing, ILPT - Industrial Logistics Properties Trust, A-I Chips.
2024-10-1946 min
InvestTalk9 Costly Retirement Investing Mistakes to AvoidFailing to diversify your portfolio and overlooking the effects of inflation are two of the nine common investing blunders. Today's Stocks & Topics: MOS - Mosaic Co., Market Wrap, GIB.A - CGI Inc. Cl A, VBR - Vanguard Small-Cap Value ETF, 9 Costly Retirement Investing Mistakes to Avoid, KPP Newsletter, AMZN - Amazon.com Inc., Key Benchmark Number: Treasury Yields, Gold, Silver, Oil and Gasoline, Annuities, Global Inflation, SNOXX - Schwab Treasury Obligations Money Inv., XOM - Exxon Mobil Corp., TXG - 10x Genomics Inc., Soft Landing, ILPT - Industrial Logistics Properties Trust, A-I Chips.
2024-10-1946 minThe Bio ReportBringing Cellular Diversity into Sharper FocusFrom cell to cell within a given tissue, variability exists. Single-cell sequencing technologies from 10X Genomics is helping researchers and drug developers understand cellular diversity in tissue once thought to be made up of homogenous populations. This has the potential to lead to new understandings of diseases, open up new targets for drug developers, and provide for more tailored approaches to the treatment of diseases. We spoke to Michael Schnall-Levin, chief technology officer and founding scientist of 10X Genomics, about the company’s platform technologies, the diversity of the cellular populations within the body, and how this is changing ou...
2024-10-0230 min
You, me & the UPCEp 7: Protective OrdersIn this episode of You, me and the UPC, Charlie French and Naomi Hazenberg are joined by Eden Winlow to discuss the regime for protecting trade secrets and other confidential information in the UPC. The team cover decisions from the Dusseldorf Local Division in 10x Genomics v Curio and Fujifilm v Kodak, the Hague Local Division in Plant-e v Arkyne and the Paris Local Division in C-Kore v Novawell. Finally, the conversation turns to some practical points that have arisen from the discussion of the protection of confidential material in other cases.Note: This episode...
2024-07-2524 min
Molecule to Market: Inside the outsourcing spaceAI as a force for good in drug developmentIn this episode of Molecule to Market, you’ll go inside the outsourcing space of the global drug development sector with Vijay Vaswani, Co-Founder & CEO at Omniscope.
Your host, Raman Sehgal, discusses the pharmaceutical and biotechnology supply chain with Vijay, covering:
How travel expands the mind and enables you to amplify your network
The founding story of Omniscope and its mission of using tech to help unlock the immune system
AI can read the immune system in HD, helping with clinical trials and predictive candidate selection
How you should be thinking about AI for drug discovery an...
2024-07-1952 min
Life Sciences 360Vector Labs CEO Lisa Sellers on Innovation, Leadership, and MentorshipWelcome to episode 054 of Life Sciences 360.In this episode of Life Science 360 ,Today, we are thrilled to have Lisa Sellers, the CEO of Vector Labs, as our special guest. Lisa shares her incredible journey from working at big names like Thermo Fisher and 10x Genomics to leading Vector Labs, a trusted manufacturer of reagents and critical components in the life sciences sector.In this episode, we dive deep into:- Lisa's transition from being an industry professional to becoming a CEO- The unique challenges and benefits of working in smaller companies...
2024-07-1642 min
HR UnpluggedThe Best Way to Teach Leaders to Deliver FeedbackDelivering feedback can be a daunting process (on both sides) but coming to it with a commitment to improvement will help you take the best steps forward. In this episode of HR Unplugged, Head of HR Anita Grantham sits down with Rebecca Port, the Chief People Officer at 10x Genomics. Together, they swap tips on the best approaches for delivering feedback – both positive and negative. They explore the benefits of continuous feedback, how role-playing can help you tackle difficult discussions, and why all feedback should be delivered with kindness, care, and compassion. Rebecca also breaks down...
2024-06-1831 minYou, me & the UPCEp 6: Preliminary InjunctionsIn this episode of You, me & the UPC, Charlie French and Naomi Hazenberg cover the eight UPC preliminary injunction (PI) decisions to date. They discuss the legal points that have emerged from the various inter partes PI decisions, including the Court of Appeal decision in 10x Genomics v NanoString and the recent decision from the Düsseldorf Local Division in 10x Genomics v Curio, as well as ex parte PIs and the impact of filing a protective letter in the UPC.Note: the UPC Court of Appeal’s decision in Vusion Group SA (formerly SES-imagotag SA...
2024-05-1324 min
Freeman Means Business' Wonder Women in Business PodcastWonder Woman in Business, Lisa SellersLisa V. Sellers, PhD, CEO of Vector Laboratories, is an accomplished leader and mentor in life sciences with
more than 20 years of experience in the industry. Sellers drives expansion and business strategies for Vector Laboratories, a trusted reagent and critical component manufacturing partner that empowers biopharma, life science tools and diagnostics companies to accelerate their ability to provide value to their customers. Sellers has a stellar track record of spearheading successful business strategies based on unmet market opportunities, while prioritizing the development of a people-first work environment. This winning combination has created unstoppable forward momentum at Vector Laboratories.
2024-04-0651 min
Biotech 2050 PodcastBiotech's Game Changers & Revolutionizing Therapeutics, Dr. Mammen, CEO, FogPharmaSynopsis:
In this episode of the Biotech2050 podcast, Dr. Mathai Mammen, CEO of FogPharma, shares valuable insights into the future trends of the biotech industry and the development of peptide-based therapeutics. Dr. Mammen's extensive career trajectory, from academia to leading pharmaceutical organizations, provides a comprehensive understanding of the industry's evolution and the pivotal roles he played at Theravance, Merck, and J&J. The episode delves into the significance of intracellular protein interactions and FogPharma's focus on developing helicon peptides to address this unmet need. Dr. Mammen's emphasis on a moonshot culture at FogPharma, coupled with his strategic approach to commercial...
2024-03-2050 min
Aging-USTranscriptomic Modulation of Alzheimer’s Disease by Activated Protein C Using Single-Cell RNA-SeqBUFFALO, NY- March 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C.”
Single-Cell RNA sequencing reveals changes in cell population in Alzheimer’s disease (AD) model 5xFAD (5x Familial AD mutation) versus wild type (WT) mice. In this new study, researchers Mohammad Kasim Fatmi, Hao Wang, Lily Slotabec, Changhong Wen, Blaise Seale, Bi Zhao, and Ji Li from the University of South Florida, University of Mississippi Medical Center and the G.V. (Sonny...
2024-03-1303 minTouching BaseIntellia and Ultragenyx’s Clinical Updates, Novo Holdings’ Catalent Acquisition, and NanoString Bankruptcy; Simon BarnettEpisode 8 (February 9th, 2024): Intellia and Ultragenyx gave updates on their clinical trials for gene therapies for inherited rare diseases. Novo Holdings, which manages the assets of the foundation that controls Novo Nordisk, agreed to buy Catalent for $16.5 billion to keep up with the high demand for its hit drugs Wegovy and Ozempic. Spatial biology tools developer NanoString Technologies filed for bankruptcy, blaming the $31 million jury award assessed against it last November in a patent infringement case filed by rival 10x Genomics. Plus, an interview with Simon Barnett, research director at Dimension. Listed below are key r...
2024-02-0944 min
Science FarePart 2 of Jill Herschleb on Discovery-Based Research with Single-Cell GenomicsJill Herschleb, senior director of cell biology at 10x Genomics, talks about her path as a scientist and her work in building the tools that have helped make single-cell genomics the robust and flexible technology it is today. Here is an informative video on single cell genomics and its use in the effort to make a comprehensive human cell map (aka, the Human Cell Atlas). In Part 2 of this conversation, we discuss:*the idea of a cell as a test tube in single-cell genomics, and setting up massively parallel (millions an...
2024-01-1744 minTouching BaseJ.P. Morgan 2024: Illumina, 10x, Danaher, AI; Liberate BioEpisode 4 (January 12, 2024): Takeaways from the J.P. Morgan Health Care conference: Illumina, Danaher, 10x, Empress Therapeutics; an interview with Liberate Bio’s Shawn Davis and Walter Strapps. Listed below are references to relevant GEN stories discussed in this episode of Touching Base: JPM: Illumina’s new CEO spells out 2024 priorities, presents preliminary Q4 2023 results By Alex Philippidis, GEN, January 10, 2024. JPM: Prime Medicine eyes 2024 IND for first prime editing therapy By Alex Philippidis, GEN, January 9, 2024 JPM 2024: Veracyte’s C2i genomics acquisition adds AI readouts to liquid biopsy testing By Jonathan...
2024-01-1143 min
BARDEHLE IP ExpertsIP Quick Tip: First experiences at the UPC
To browse the latest decisions rendered by the UPC, please refer to our UPC decisions database.
Hi everyone, welcome to this IP Quick Tip relating to our first experiences at the UPC. It goes without saying that all of this is very exciting and still in its early stages. However, certain trends already seem to be robust. As of mid-October 2023, 84 cases have been filed and BARDEHLE PAGENBERG is representing plaintiffs and defendants alike in 21 of these cases, having an amazing market share of exactly 25%.
Not only were we “first” in filing the initial cases on day...
2024-01-1003 minScience FareJill Herschleb on Discovery-Based Research with Single-Cell GenomicsEpisode #8.Jill Herschleb, senior director of cell biology at 10x Genomics, talks about her path as a scientist and her work in building the tools that have helped make single-cell genomics the robust and flexible technology it is today. Here is an informative video on single cell genomics and its use in the effort to make a comprehensive human cell map (aka, the Human Cell Atlas). In Part 1 of this conversation, we discuss:*How Jill got interested in science as a kid [2:30]*Jill’s grad scho...
2024-01-1034 min
The Single-Cell World PodcastEp.41: Single-Cell Sequencing Products 2023 Review_Part 2Hi there!Today is Part 2 of the review of single-cell-related products launched in 2023. I hope I don't miss any. If I do, send me a message telling me about it. 😉Here are some useful links:Exploring Single-Cell Sequencing online courseCompanies that I talk during this episode (part 2):Scale BiosciencesScipio BioscienceSingleron BiotechnologiesTakara Bio10X GenomicsFree ResourcesSponsorshipPay me a Ko-FiThanks for listening!Cheers,
2023-12-1113 min
The Single-Cell World PodcastEp. 33: PacBio’ MAS-Seq: Long-Read Sequencing For Single-CellIn this episode, Dr. Elizabeth Tseng, associate director product manager at PacBio, explains everything about the MAS-Seq kit, a game-changer for producing long-read libraries. With the backing of single-cell industry giant 10X Genomics, the MAS-Seq kit promises to redefine the future of single-cell RNA seq assays.Whether you're a scientist or just curious about the future of single-cell research, this episode is your guide to the cutting-edge advancements in the field. Tune in to learn, explore, and be amazed! Some interesting links:Dr. Elizabeth Tseng, Social Media: X and LinkdeInPacBio Resources:
2023-10-0923 min
Physicians Off The Beaten Path51- Physician-Executive Series: Shehnaaz Suliman, MD (ReCode Therapeutics)What did you optimize for when choosing the first position outside the clinical path? What are the challenges that M.D.s could encounter when leaving clinical medicine? What is the role of immigrant mentality in building risk tolerance? Dr. Shehnaaz answers!
Dr. Shehnaaz Suliman is a visionary physician, drug developer, and dealmaker with over 25 years of experience reshaping the biotech landscape. She is C.E.O. and board member at ReCode Therapeutics, an integrated genetic medicines company located in California that works on developing disease-modifying therapeutics using its powerful L.N.P. delivery technology to target...
2023-09-2744 min
The Culture CodeCulture Hinges on Great Hiring: Here’s How to Approach It w/ 10x Genomics' CPOThis episode covers the integral link between company culture and hiring. Learn from the enlightening journey of 10x Genomics, a life sciences pioneer with over 25 groundbreaking products under its belt. The company’s Chief People Officer, Dr. Rebecca Port, shares her unfiltered insights, explaining how 10x Genomics shapes its culture through a unique and selective recruitment process.Key takeaways from this episode:The risks of oversimplifying culture: Why catchy phrases can be limiting.How a "warts and all" approach to recruitment can empower candidates to self-select.The importance of feedback and how 10x Genomics has in...
2023-09-2219 min
The Single-Cell World PodcastEp. 25: Illumina NGS and Single-Cell ExperimentsHi there!Dive into our most recent audio episode as we discuss Illumina Next Generation Sequencing (NGS) technology with our distinguished guest, Sophie Wehrkamp-Richter, product manager at the company. Immerse yourself in our vibrant debate about the critical role of DNA sequencing in single-cell research. Furthermore, we investigate critical aspects to consider when planning a single-cell experiment.Listen now and feed your curiosity!Useful Links:Single-Cell Illumina ebook and application notes Joint single- cell company: With 10x Genomicshttps://developer.illumina.com/news-updates/10x-genomics-chromium-single-cell-gene-expression-flex-data-now-available-on-illumina-basespace-sequence-hubhttps://developer.illumina.com/news-updates...
2023-07-3125 min
The Single-Cell World PodcastEp. 24: Single-Cell MultiomicsHi there,Today's episode is about one of the trends on single-cell research: single-cell multiomics. Listen now to know more about the types os single-cell multiomics and the available kits that you can use.Support this podcastUseful Links:10X Genomics Multiome kitBD Biosciences KitsMission Bio MultiomicsBiolegend AntibodiesThanks for listening!Cátia This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit thesinglecellworld.substack.com
2023-07-2411 min
Your Brain at WorkA New Approach to Doing More With lessMaybe this line sounds familiar: You've got to do more with less — less time, less funding, and fewer resources. In an economic environment where reductions in force and demands for ramped up productivity — with sustainable business margins — are commonplace, does efficiency have to mean austerity? Perhaps not.
In this episode of Your Brain at Work, Dr. Rebecca "Becks" Port — Chief People Officer at 10X Genomics — connects with the NeuroLeadership Institute's co-founder, Dr. David Rock, to explore strategies for improving talent and business outcomes by improving talent density.
2023-06-0254 min
Stock Market Today With IBDStocks Mixed, Is Growth Ready To Lead? Shopify, 10x Genomics, Kinsale In FocusMarkets were mixed on Monday but it wasn’t all bad. Advancers beat decliners and if money moves aways from consumer staples, is growth the destination? Shopify tried to break above a downtrend, 10x Genomics moved out of a flat base, and Kinsale is setting up. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-05-2219 min
The Single-Cell World PodcastEp15: Single-Cell DNA Sequencing Methods: an overviewHi there,In this podcast episode, I will be talking about single-cell DNA. DNA is the information necessary to build our bodies. Alterations in DNA can cause changes in cell behavior, leading to diseases.To study DNA at the single-cell level, we can use diferent protocols. Some examples are the whole-genome or the targeted approaches, the scATAC-seq or the scDNA methulation protocols. Several commercial solutions are available and I will also mention them.Listen now!Cheers,CátiaUsefull LinksLAST DAY!! Single-Cell Course: Exploring the Cutting-Edge W...
2023-05-0815 min
Cultured Meat and Future Food PodcastJeremy Agresti of TriplebarJeremy Agresti has spent his career developing tools to drastically change the pace of biology with massive-throughput measurements using microfluidics. His seminal contributions as pioneer of miniaturizing biology with microfluidics have resulted in a large number of publications and patents, which have been cited more than 9,000 times, and form the foundation of several companies in the space. His work has allowed Amyris to bring their biofuels and chemicals to market faster, and for companies like Bio-Rad, Illumina and 10x Genomics to bring new single-cell genomics tools and clinical diagnostic tests to market. Jeremy is a co-founder and advisor to...
2023-05-0435 min
The Single-Cell World PodcastEp.14: Single-Cell Methods: an overviewWelcome!In this episode I will talk about the 3 main methods that were the base for the different single-cell sequencing technology. Below you can find all companies and products links that are mentioned during this episode. I hope this is useful for your and somehow can help. Thanks for listening!PLATE-BASED METHODS (e.g. commercial options)96 well Plates (BioRad)REPLI-g Advanced DNA Single Cell Kit (Qiagen)SMART-Seq Single Cell Kit (Takara Bio)Evercode Whole Trancriptome (Parse Biosciences)Micro, Nano or Pico WELL-BASED METHODS (e.g. commercial options)HIVE scRNAseq...
2023-05-0111 min
The Single-Cell World PodcastEp.11: Sample Preservation Methods For Single-Cell ExperimentsHello there!Season two of The Single-Cell Podcast begins today.In this episode, I discuss the various preservation methods that can be used on samples for single-cell sequencing experiments.TopicsCryopreservationSnap-freezingFixationSpecific single-cell strategies developed by various single-cell sequencing technologies like Singleron, 10X Genomics, Honeycomb Biotechnologies, Parse BiosciencesThe courseExploring the Cutting-Edge World of Single-Cell Technology: An Introductory CourseFor more detailsPay me a kofi to support this podcastThank you! This is a...
2023-04-1017 min
Axial PodcastFounding Infinimmune & Developing Breakthrough Tools for Antibody Discovery with Wyatt McDonnellIn our conversation with Wyatt McDonnell, the Co-Founder and CEO of Infinimmune, we discuss his journey to 10X Genomics, his work there, and the founding of Infinimmune. Wyatt is a world-class inventor & immunologist working across a wide range of projects at 10X from launching BEAM (barcode-enabled antigen mapping), working on the Immune Profiling v2 product, and developing various immune repertoire technologies. After making a significant impact on 10X, Wyatt along with 4 other colleagues that had worked together founded Infinimmune to transform human antibodies into drugs.
A key theme of the conversation is that tool users greatly...
2023-03-2456 min
On AIRR - Immune receptors in the clinicOn AIRR 8: Engineering B cells or Giving the immune System an Optimal Starting Point with Dr. Adi BarzelDr. Adi Barzel is an associate professor in the department of Biochemistry & Molecular Biology at Tel Aviv University, Tel Aviv, Israel. Adi is President at Israeli Society of Gene and Cell Therapy.
Following Adi’s long standing interest in gene editing, we discuss the therapeutic potential based on Adi’s recent paper “In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice” (Nat Biotechnol.; 2022; https://doi.org/10.1038/s41587-022-01328-9). We also briefly touch on a second paper on some of the problems with CRISPR-Cas9 gene editing (“Frequent aneuploidy in primary human T ce...
2022-10-0739 min
Alles auf Aktien – Die täglichen Finanzen-NewsHoffen auf Pharma-Jackpot und luxuriöse Zuteilung bei Porsche29.9. - Der tägliche Börsen-Shot
In der heutigen Folge „Alles auf Aktien“ sprechen die Finanzjournalisten Anja Ettel und Holger Zschäpitz über die britische Notenbank als Kavallerie der Märkte, die Gaspreisdeckel-Klatsche für Energiefresser und frischen Wind fürs Depot.
Außerdem geht es um Porsche, Biogen, Eisai, Roche, Morphosys, Eli Lilly, ThyssenKrupp, Salzgitter, Commerzbank, Deutsche Bank, Apple, VW, Glencore, Ginkgo Bioworks, Invitae, Twist, 10x Genomics, Uipath, Invesco Wind Energy (WKN: A3DP7S), Global X Wind Energy (WKN: A3C9MA), Orsted, Siemens Gamesa, Vestas, Boralex, Axiona Energias Renovables, Ming Yang Smart Energy, SGL Carbon, SKF...
2022-09-2918 min
Epigenetics PodcastSingle Cell Epigenomics in Neuronal Development (Tim Petros)In this episode of the Epigenetics Podcast, we caught up with Tim Petros from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the NIH to talk about his work on Single Cell Epigenomics in Neuronal Development.
The Petros lab focuses on “interneurons”, their diversity and how environmental signals interact to generate this diversity. This subgroup of neurons comprise about 20% of neutrons in the brain, however, they are the primary source of inhibition. Furthermore, interneurons are critical components in modulating information flow throughout the nervous system. The Petros lab seeks to uncover the genet...
2022-08-2537 min
Cell IntelStudying T-Cell Exhaustion in Brain MetastasesWe talk with Dr. William Hudson about his work at Emory University, where he combines single cell immune profiling and spatial analysis to inform development of immunotherapies for brain cancer.
2022-04-1533 minEpigenetics PodcastMultimodal Characterization of Cellular Identity | CITE-Seq and Beyond (Peter Smibert, VP of 10X Genomics)In this episode of the Epigenetics Podcast, we speak with Peter Smibert, Vice President of Biology at 10X Genomics to talk about an exciting new method in Multimodal Characterization of Cellular Identity using Barcoding.
During his time at the New York Genome Center, Peter Smibert was instrumental in the development of a new method called "Cellular Indexing of Transcriptomes and Epitopes by Sequencing" short CITE-Seq. This method enables the characterization of a cell's transcriptome, while at the same time, also allows the characterization of the cell's protein surface markers - at the single cell level. In CITE-Seq...
2022-04-1448 minEpigenetics PodcastSingle-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)In this episode of the Epigenetics Podcast, we caught up with Ben Hindson, Chief Scientific Officer at 10X Genomics, to talk about single-cell technologies using microfluidics.
Epigenetics has moved well past a simple understanding of a single epigenetic layer of control at genomic regions of interest, thanks to advances in many techniques and the application of “multiomics”. We can now analyze genome-wide histone modification patterns, transcription factor binding profiles, chromatin accessibility profiles, three-dimensional chromosomal conformation, and DNA methylation dynamics combined with transcriptomic analyses and associated analytical platforms.
Bulk Assays, like ATAC-Seq or ChIP, despite all thei...
2022-03-1638 min
Mendelspod PodcastAkoya Biosciences Launches New Integrated Spatial Platform: Our First Interview with CEO Brian McKelligonEven though Brian McKelligon calls himself a rookie CEO, he comes to the top position at Akoya Biosciences with a veteran’s resume. His path to one of spatial biology’s hottest companies in 2022 worked him up the ranks of some of the top names in life science tools: Affymetrix, Ingenuity, Ion Torrent, and 10X Genomics. Last year Brian led Akoya through an IPO and this year the company has launched a new integrated product line called the Phenocycler-Fusion which they are calling the fastest single-cell spatial biology system on the market. This is a public episode. If you...
2022-02-2430 min
Mendelspod PodcastGoing High Resolution with 10X Genomics: Michael Schnall-LevinWorking at the Broad Institute early in his career, Michael Schnall Levin was discovering he was a biologist at heart. He’d begun his studies in physics then done his PhD in mathematics. But he'd wanted “to do math that had an application in the real world.” It was at the Broad that Michael came in contact with the new tools that were revolutionizing biology. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe
2022-01-2737 min
NeuroRadio#30 Being a technologist at 10x初のインダストリーからのゲスト。Wyss Institute から 10x Genomics に就職された佐々木浩さん(@popeetheclown)にお越しいただき、アカデミアとインダストリーの研究スタイルや自由の違い、海外就活の詳細なタイムラインと勘所、インダストリー研究ならではの醍醐味について伺いました（11/22 収録）
Shownotes:
佐々木浩さん
10x Genomics
Wyss Institute HP
泊研HP
RISCの形成過程再構成＆一分子イメージングのお仕事 論文 筆頭著者レビュー
aaRS(PheRS)に関する構造生物学のお仕事
DNA-PAINTの簡単な説明
ぽん（Peng Yin）ラボHP
DECODE-PAINTのお仕事（講演アブスト）
兵庫県立大学の吉久先生
日本RNA学会
上海科技大学の多田隈さん
DNA Origami 2006の論文
University of Washington の Brianラボ
アカデミアとインダストリーの自由度について、 HarvardのテニュアからGoogleに行ったMatt Welsh氏のブログポスト
10xが進めているin situプロダクトの情報
10xのファウンダー：Serge Saxonov と Ben Hindson
最初のプロダクト(Chromium)
Swedenにあった会社(Spatial Transcriptomics, Cartana) (10xはスウェーデンのスタートアップを2社買収していて、Spatial Transcriptomics -> Visium、Cartana -> New in situ platformというようになっています by 佐々木さん)
David Hoffman
Eric Betzig 超解像で2014年ノーベル賞
David HoffmanのScienceの仕事
Wyss時代に隣のラボにいた友達で、現在の同僚 Eswar Iyer
元々はTwitterで出会って仲良くなった友達 Sizun Jiang
10xでの直属の上司 Justin Costa
Ting Wu
Josie (Kishi)
ストックオプション：会社の株式をあらかじめ定めた価格で将来取得する権利
IPO：会社の株を初めて誰にでも取引できるようにすること
10x Genomicsのジョブオープニング
Neuralinkのホワイトペーパー
Melissa Moore@Moderna
Melissa Mooreによるレクチャー（をまとめた記事）
Editorial Notes:
Wyssのスローガンの一つに “Breakthrough discoveries cannot change the world if they do not leave the lab” というのがありますが、こういうことなんだな～と腹落ちした回でした (宮脇)
録音チェックのために改めて聞き直すと、宮脇さん良い声だな……と思いました(佐々木)
自分のいない収録音源を編集するのは、いちリスナーとして新鮮に聴けてよかったです(萩原)
2021-12-241h 59
What's Next｜科技早知道S5 年度回顾系列 EP1｜2021 过去了，我们为什么依旧看好生物科技？为什么当我们讨论今年最火热的投资赛道时，还是无可避免地要提到生物科技？毕马威的最新报告显示，2021 年生物科技领域占全球风险投资总额的 15% 以上，细分赛道上不断涌现的玩家依旧是投资人眼中的当红炸子鸡。包括港交所及德勤在内的全球多个交易所和咨询机构都表示，受疫情催化影响而身价暴涨的生物科技产业，还会在未来继续吸引全球资本市场的视线。
作为年度回顾系列的第一期节目，主播 Diane 正式回归，与老朋友 Fusion Fund 管理合伙人张璐及 co-host 刘灿， 共同讨论 2021 年的生物科技领域都有哪些令人印象深刻的玩家和商业变化，硅谷投资人如何评价估值过高的论点，互联网公司的入局会给行业带来什么变化，对于 2022 年我们还有哪些期待？
#声动小邮筒#
对 Diane 和 Carter 的讨论好奇但尚未订阅的小伙伴，欢迎点击这里的报名链接，订阅我们的「声动小邮筒」📮。当然，你也可以关注「声动活泼」的微信公众号，在对话框直接回复【邮件】即可了解更多详情。
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声动活泼正在招聘「内容研究员」、「业务拓展和合作管理总监/经理」、「声音设计师」、「播客制作实习生」、「内容营销负责人」及「节目制作人」，查看详细讯息请在公号「声动活泼」回复暗号：入场券 。简历接收邮箱📮 hr@shengfm.cn 。
▼主播
丁教，「声动活泼」联合创始人
刘灿，「科技早知道」节目监制
▼嘉宾
张璐，Fusion Fund 管理合伙人
▼主要话题
[03:53] 今年印象最深刻的公司和技术？
[12:43] 哪些赛道有泡沫吗？
[25:12] 投资周期是缩短了，还是变长了？
[35:31] 医疗数据与隐私保护值得关注？
[47:58] 一句话总结 2022 年的期待
▼延伸阅读
Isomorphic Labs is Alphabet's play in AI drug discovery
Amazon announces new wearable and services to try to make you fitter
Wearable, 'Skin-Like' Electronics Support Wireless Functionality
What Causes Alzheimer's Disease?
微流控（ Microfluidics ）：指在一块芯片上完成样品制备、反应、分离、检测等医疗生物分析全流程的技术，其中涉及生物、新材料、微电子、流体物理等多门学科，可以实现对蛋白质、核酸的快速处理和检测。
联邦学习（ Federated learning ）：分布式的机器学习方法，目标是解决数据孤岛，在大量数据交互和共同建模的情况下仍能保护用户隐私和数据安全。
生物传感：新型生物检测分析技术，结合了生物特异性识别和传感技术，热门研究方向包括活体测定、生物反应工程、可穿戴设备与无创检测等，比如针对糖尿病人的无创血糖检测。
Color：美国的健康科技独角兽公司，通过采用患者的唾液样本完成较高质量的基因检测；今年 11 月完成由 Kindred Ventures 和 T. Rowe Price Associates, Inc. 领投的 1 亿美元 E 轮融资，投后估值 46 亿美元。
Venrock：生物科技领域著名的早期投资机构，脱胎于洛克菲勒家族的 Rockefeller Brothers, Inc.，成功案例包括吉利德科学、Illumina 、10x Genomics 。
▼音乐
Computer Wiz-Marten Moses
▼Staff
监制^ 刘灿
后期^ Luke
运营^ Yao
封面设计^ 饭团
▼关于节目
原「硅谷早知道」，全新改版后为「What's Next｜科技早知道」。放眼全球，聚焦科技发展，关注商业格局变化。
▼关于我们
声动活泼的宗旨是「用声音碰撞世界」，并致力于为人们提供源源不断的思考养料。
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Special Guest: 张璐.
2021-12-2151 min
Cell IntelResearching Therapies for Type 1 Diabetes, Part 2The conversation continues in Part 2 of our chat with Todd and Maigan Brusko at the University of Florida, Gainesville, as they go even further into their research on Type 1 Diabetes.
2021-12-2025 min
Cell IntelResearching Therapies for Type 1 Diabetes, Part 1In this episode, we're kicking off a fascinating two-part discussion with Todd and Maigan Brusko at the University of Florida, Gainesville, about their research on Type 1 Diabetes.
2021-12-2029 min
The Scientist’s LabTalkPhagocidal Macrophages: A New Battle Tactic Against Resistant CancersCancer immunotherapies are saving lives, but researchers still have a long journey ahead of them. Many cancers that are initially sensitive to immunotherapy acquire resistance over time, while others are resistant from the beginning.
In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Stephanie Dougan, an associate professor of immunology at Harvard Medical School and a principal investigator at Dana Farber Cancer Institute, about her research developing new immunotherapies for resistant tumors.
LabTalk is a special edition podcast produced by The Scientist’s Creative Services Team, where we explore topics at t...
2021-11-2912 min
Investor Audio: Company Breakdowns10X Genomics Inc: TXG (2020) - Mastering Biology to Advance Human HealthLet’s understand the business from the company that builds products to interrogate, understand and master biology.Industry: Health Information Services 🔗SEC Website ► Company Filing👍Support the Investor Audio Digital Library ► https://www.investoraudio.io/support/🕸️More Investor Audio Content ►https://linktr.ee/investoraudio👍Follow the show if you liked the episode. Created and hosted by Igli Gezim Laçi🐦https://twitter.com/IgliLaciMission: Investor Audio is...
2021-11-1521 minThe Scientist’s LabTalkHijacking Genes: Uncovering the Cause of Lineage Ambiguous LeukemiaChildhood cancer is devastating. Every year over 15,000 children in the United States are diagnosed with cancer, with leukemia accounting for 28% of all childhood cancers in children under the age of 15. Leukemia, however, is not a single class of cancer. There are numerous forms of leukemia each with its own distinct cause.
In this episode, Tiffany Garbutt from The Scientist’s Creative Services team spoke with Charles Mullighan, member of the department of pathology and deputy director of the Comprehensive Cancer Center at St. Jude Children’s Research Hospital, about the search for the molecular drivers underlying lineage ambigu...
2021-10-3116 min
Cell IntelNeurophysiology Meets Spatial TranscriptomicsWe sit down with DO/PhD candidate Dianna Nguyen, a member of Tom Cunningham’s lab, and former core lab manager at the University of North Texas Health Science Center, Nicky Hales. Hear how one spatial transcriptomics experiment can change the direction of a research project and open up new sets of questions and paths of further study.Take scalable single cell analysis from your wish list to the bench with our September 2021 Chromium X Special Offerhttps://pages.10xgenomics.com/2021-09-instrument-reagent-promo.htmlDon't delay! Get your order in by Se...
2021-09-1032 min
Cell IntelSingle Cell Immunology at the University of PittsburghIn this episode, we talk about single cell analysis of the immune response in diverse disease types, from cancer to COVID-19, with researchers at the University of Pittsburgh: Tony Cillo, PhD, Postdoctoral Associate in the Vignali Lab in the Department of Immunology and Hillman Cancer Center, and Bob Lafyatis, MD, Professor of Medicine in the Division of Rheumatology and Clinical Immunology.Link mentioned in the episode: 10xgenomics.com/gem6
2021-08-1930 minThe Scientist’s LabTalkUnderstanding Microglial Response in Alzheimer’s DiseaseA diverse population of microglial cells resides in the brain. Similar to immune cells, microglial cells respond to minute changes in their environment. Sometimes this response is beneficial and other times detrimental. Scientists are working to tease apart the dynamic role of microglial response in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease.
In this episode, Tiffany Garbutt from The Scientist’s Creative Services team spoke with Samuel Marsh, a postdoctoral research fellow in the laboratory of Beth Stevens at Boston’s Children’s Hospital and Harvard Medical School, about how he uses single cell technolo...
2021-07-3116 min
Cell IntelBeyond the TranscriptomeWe talk with Mathieu Lupien, PhD, a senior scientist at the Princess Margaret Cancer Centre and associate professor at the University of Toronto in Canada. Hear how studying chromatin state and transcription in individual cells has opened up a new area of research in gene regulation and cancer progression.
2021-07-2935 min
Cell IntelAccess PointsWe talk with Olivia Koues, PhD, managing director of the Advanced Genomics Core at the University of Michigan, about the role of a 10x Genomics Certified Service Provider in supporting your experiments.
2021-07-0233 minThe Scientist’s LabTalkThe Promise of Spatial Transcriptomics in Exploring Chronic Liver DiseaseThe liver performs approximately 500 separate functions in the human body. With liver disease on the rise, scientists are developing treatments to save this irreplaceable organ.
In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Prakash Ramachandran, a clinician scientist at the Centre for Inflammation Research at the University of Edinburgh, about mechanisms of scarring that lead to chronic liver disease and what he hopes to learn from biobanked patient liver samples.
The Scientist Speaks is a podcast produced by The Scientist’s Creative Services team. Our podcast is by scientists and...
2021-06-3015 min
Cell IntelTalkin’ About a Resolution, Part 3And you thought you could only resolve cellular heterogeneity in fresh frozen tissue. Time to bring out the FFPE blocks!
2021-06-0325 min
Cell IntelTalkin’ About A Resolution, Part 2You may be familiar with how single cells get isolated or tissue gets sliced, but do you know how to mine the most important results in all that data? We describe tools developed by 10x Genomics as well as a few from third parties that can further extend your analysis, such as Seurat, Azimuth and Monacle.
2021-06-0227 min
Cell IntelTalkin’ About a Resolution, Part 1Maybe you're asking, "Who are these people? Why are they hosting a podcast?" Find out the answers to these questions and more in this first episode of the Cell Intel podcast from 10x Genomics.
2021-06-0137 minThe Scientist’s LabTalkDiscovering the Secrets of Motor Neurons with Single Cell SequencingMotor neurons originating in the spine control both voluntary and involuntary movements. Even though they have an essential function, they are notoriously difficult to study.
In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with Jacob Blum, a graduate student in Aaron Gitler’s laboratory at Stanford University, about his work understanding the diversity of spinal motor neurons using single cell transcriptomics.
The Scientist Speaks is a podcast produced by The Scientist’s Creative Services team. Our podcast is by scientists and for scientists. Once a month, we bring you the storie...
2021-05-0513 min
MBAsians: The Asian MBA PodcastFrom MBA to Healthcare Startup: 10x Genomics Senior Financial Analyst Yoonki Lee // Duke Fuqua 2019For this episode, we invited Yoonki Lee, a Fuqua MBA graduate from class of 2019, to share his experience of working in a healthcare company, 10x Genomics, in the US. He will also share the challenges he faced as a financial analyst when the company is transitioning from a startup to a public company. Meet Yoonki Lee!Yoonki was born and raised in Korea. After working at Samsung Biologics for almost 3 years, he decided to pursue an MBA degree at Duke Fuqua. While he was in the MBA program, he also interned at NovaQuest Cap...
2021-04-1433 minThe Scientist’s LabTalkPredicting the Immune Response with Single-Cell Analysis: Autoimmunity, Vaccination, and COVID-19The human immune system is highly complex and variable. Some people mount robust responses to infection, vaccination, or immunotherapy, while others fail to react appropriately. These differences have obvious implications for health and disease, and they have been especially appreciated during the COVID-19 pandemic as some individuals show no symptoms after contracting SARS-CoV-2 while others experience severe, life-threatening disease.
In this episode, Niki Spahich from The Scientist’s Creative Services team spoke with John Tsang, co-director of the National Institutes of Health Center for Human Immunology about how he uses innovative single-cell technology to discover early predictors of...
2021-03-3117 min
The Earnings Podcast from AlphaStreet10x Genomics Inc Q4 2020 Earnings Call10x Genomics Inc Q4 2020 Earnings Call
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2021-02-181h 05
The Scientist SpeaksDecoding Smell: Demystifying Human Disease and BehaviorOdors bombard the human nose every day, whether the odors register consciously or not. The way the human brain processes these odors has the potential to characterize disease and shape everyday human interaction.
In this month’s episode, we explore the world of odor and how scientists use the sense of smell to better understand the human brain, disease, and behavior. Tiffany Garbutt from The Scientist’s Creative Services team spoke with Noam Sobel, Sela Professor of Neurobiology and Director of the Azrieli National Center for Human Brain Imaging and Research at the Weizmann Institute of Science, to le...
2020-12-2218 minThe Scientist SpeaksCancer Immunotherapy: CRISPR Reveals Targets In VivoWelcome to The Scientist Speaks, a podcast produced by The Scientist’s Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we bring you the stories behind news-worthy molecular biology research.
This episode is brought to you by 10x Genomics. 10x Genomics builds solutions to interrogate biological systems at a resolution and scale that matches the complexity of biology. Their rapidly expanding suite of products, which include instruments, consumables, and software, has enabled customers to make fundamental discoveries across multiple research areas, including cancer, immunology, and neuroscience.
While T cell im...
2020-12-0813 min
Researchat.fm80. Guest explains everythingpomeさんをゲストに迎え、TALEN・UCART治療・シングルセル解析・核酸医薬・DNA合成に関する技術と関連のバイオテック企業の動向について話を伺いました。Shownotes
Researchat.fm ep79…pomeさんゲスト回前編はこちらです。
TALEN…詳しくはResearchat.fm ep76
Cellectis … Swedenではなく、Franceの企業だったようです。(BB氏訂正ありがとうございました。)
CAR-T
UCART…Universal Chimeric Antigen Receptor T-cells。”Off-the-shelf”ってかっこいいですね。
T細胞 (Wikipedia)
HLA (Wikipedia)
NK細胞 (Wikipedia)
CD47 (Uniprot)
Pfizer
Allogene Therapeutics
CRISPR (Wikipedia)…Researchat.fmの過去回をお聞きください。Researchat.fm ep76、Researchat.fm ep77など
iPS細胞 (Wikipedia)
Spatial Transcriptomics
10X Genomics
seqFISH
FACS (Wikipedia)
BioLegend
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets. Cell 2015…InDrop法による１細胞シングルセル解析の元論文
1CellBio
Broad Institute
アンチセンスRNA
筋ジストロフィー (Wikipedia)
核酸医薬 (Wikipedia)
siRNA (Wikipedia)
固相合成 (Wikipedia)
液相合成
T7 (NEB)
GenScript
TdT (Wikipedia) … 話が途中からDNA合成からRNA合成にすり替わってしまいましたが、RNA合成の基本であるIVT(in vitro transcription)に関してはまたいつか話します。
Molecular Assemblies, Inc
Enzymatic DNA synthesis enters new phase. Nature Biotech 2020…TdTを用いたDNA合成の最前線に関する記事(2020/10月)
De novo DNA synthesis using polymerase-nucleotide conjugates. Nature Biotech 2018…TdTを用いた核酸合成の元論文。
Modern
2020-11-2040 minThe Scientist’s LabTalkSurviving Stress: The Mysteries of Neuronal Survival and NeurodegenerationWelcome to The Scientist’s LabTalk, a special edition podcast produced by The Scientist’s Creative Services Team where we explore topics at the leading edge of innovative research.
In this episode, we explore how neurons withstand stress by looking at three cutting edge technologies: CRISPR, stem cell technology, and single-cell sequencing. Tiffany Garbutt from The Scientist’s Creative Services team spoke with Martin Kampmann, associate professor at the University of California San Francisco, Chan Zuckerberg Biohub investigator, and Paul G. Allen Distinguished Investigator to learn more.
This episode is brought to you by 10x Genomic...
2020-10-2017 min
Global Venturing Review12 October 2020 2020 – Uber Spins out Uber Freight with $500m Series AThe Big Ones
Uber launched its shipping services platform, Uber Freight, in 2017, and is now spinning it off with $500m in series A financing from Greenbriar Equity Group at a $3.3bn post-money valuation. The funding will help Uber Freight compete against emerging competitors like Flock Freight and Loadsmart, as well as international rivals such as BlackBuck, FreightHub and Manbang Group.
Several corporates have in the past year or so adjusted their CVC models to focus on independent venture firms they sponsor, as opposed to operating internal units. But Russian conglomerate Sistema was among the first...
2020-10-1224 min
The Pomp LetterThe Game Has ChangedTo investors, Chamath Palihapitiya is executing better than anyone we have seen in the public markets in a long time. He has successfully taken an old financing mechanism, the SPAC, and popularized it in a way that unleashed billions of dollars of liquidity into the market. His first deal was to bring Virgin Galactic public, which was followed by the $4.8 billion deal for OpenDoor. This morning Chamath unveiled the deal for his third SPAC — Clover Health. The Medicare insurance company will be valued at $3.7 billion and nearly $1.2 billion in cash proceeds. There will be $400 million PI...
2020-10-0605 min
DNA Today: A Genetics Podcast#132 DTC Series: Michael Schnall-Levin on Single Cell SequencingExciting Announcement: This week “DNA Today” won the Best 2020 Science and Medicine Podcast in The 15th Annual Podcast Awards! This is thanks to each and every listener who nominated and voted for the show. THANK YOU for being such loyal listeners for the past 8 years. We’ve been nominated for four years, and it’s incredible to win this year! For those that aren’t familiar, The Podcast Awards are the longest running podcast awards event open to shows worldwide, this year there was 250,000 people who nominated shows.
Michael Schnall-Levin joins host Kira Dineen on this episode to explore...
2020-10-0230 min
The Scientist SpeaksA Game of Cancer and Evolution: Scientists leverage the principles of evolution to outwit cancer at its own gameThe Scientist Speaks, is a podcast produced by The Scientist’s Creative Services Team. Our podcast is by scientists and for scientists. Once a month, we will bring you the stories behind news-worthy molecular biology research.
In this month’s episode, brought to you by The Scientist and sponsored by 10x Genomics, we discover how scientists use the principles of evolution to model tumor dynamics and develop new treatment strategies for cancer. Tiffany Garbutt from The Scientist’s Creative Services team spoke with Robert Gatenby, chairman of the radiology department and co-director of the Center for Excellence for Evoluti...
2020-08-0717 min
The Times Tech Podcast10x Genomics’ Serge Saxonov: "Never has so much brainpower been focussed on one problem"The Sunday Times’ tech correspondent Danny Fortson brings on Serge Saxonov, founder of 10x Genomics, to talk about the end of normalcy (3:00), his high-end espresso machine for biology (4:20), delivering on the promise of genomics (6:20), how 10x is contributing to the coronavirus vaccine race (8:00), why a vaccine is theoretically achievable (10:15), the global shift to Covid research (13:15), leaving the Soviet Union and landing in New York (15:30), starting 23andMe (19:20), starting 10x (22:00), why it was hard to raise money (23:25), luring Softbank as an investor (25:55), 10x's footprint (26:50), the importance of resolution (28:10), and his worst day of work (32:00) Hosted on Acast. See acast.com/privacy fo...
2020-04-1035 min
Sand Hill RoadBryan Roberts Tries to Prove Himself Wrong. So Far, He’s Been Very Right.Roberts’ Venrock funded IPO blockbusters Cloudflare and 10x Genomics. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
2020-02-1819 min
Running Through WallsBuilding a Genomics Unicorn10x Genomics CEO and co-founder Serge Saxonov joins Venrock's Bryan Roberts to discuss the founding of the company and its recent IPO. Saxonov shares his story of emigrating from Tajikistan to New York City as a teenager, learning English and becoming an entrepreneur. He talks candidly about how he's grown as a leader over his six years as CEO of the company and how the company's technology has evolved to meet customers' needs.
2020-01-1525 min
Mendelspod PodcastGenomics Going from a Passive to an Active Science: John Stuelpnagel on the “Write” RevolutionNot many people have had quite the same view on the genomics revolution as John Stuelpnagel. He co-founded Illumina, Ariosa, and Fabric Genomics (formerly Omicia). And he’s the Chairman of Fabric, 10X Genomics, and Inscripta. And not all had the foresight John did that biology would turn out to be so complex.John is our guest today to preview and describe what he calls the new “writing” phase of genomics, which he says is already underway. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episod...
2019-10-2239 minResearchat.fm27. BURN KNUCKLE!コジマプロダクションの新作ゲーム DEATH STRANDING、大乱闘スマッシュブラザーズに参戦したテリー・ボガードと格闘ゲームの歴史、地球平面説を題材にしたNetflixのドキュメンタリについて話しました。Show notes
伊藤穰一氏がMITメディアラボの所長を辞任、資金調達の不正処理で
10x Genomics’ IPO rockets past a $390M raise. FierceBiotech…シングルセル解析のベンチャー、10x Genomicsがついに上場した
Researchat.fmお便りフォーム…お待ちしております！
DEATH STRANDING (デス・ストランディング)…小島秀夫監督の最新作。PS4で11月8日発売！！
Researchat’s Blog…Podcastで話したことをもったいないのでまとめたブログがこちらに。
大乱闘スマッシュブラザーズ SPECIAL…任天堂が発売している大人気対戦型アクションゲーム。
テリー・ボガード…伝説の狼。SNKを代表するキャラクターの一人。このたび大乱闘スマッシュブラザーズへの参戦が発表された。
テリー・ボガード参戦動画…スマッシュブラザーズへテリーの参戦が発表されたときの動画。にくい演出がいっぱいなので必見！！Nintendo Direct 2019.9.5。
格闘ゲーム歴史年表 アーケード版 （仮）…アーケードの格闘ゲームの年表がまとめられている。
KAKUGE.com…格ゲー用語辞典
格闘ゲーム年表(ニコニコMUGEN Wiki)…格闘ゲームの年表についてまとめられている。MUGENが苦手な人は注意。
空手道(Wikipedia)…データイーストより1984年に発売されたゲーム。世界初のアーケード対戦格闘ゲーム（プレイヤー同士の対戦はできない）。レバーを２本使って操作を行う。続編は史上初の対戦格闘ゲーム「対戦空手道 美少女青春編」
アーバンチャンピオン…1984年に任天堂より発売されたファミコン初（そしておそらく家庭用ハード初）の対戦格闘ゲーム。
イー・アル・カンフー(Wikipedia)…1985年にコナミが発売した格闘ゲーム。体力ゲージや連続技が初めて実装された。
ストリートファイター(Wikipedia)…カプコンが1987年に発売した2D対戦格闘ゲーム。ストリートファイターシリーズの第一作目。ボタン（大きな気圧式）を押した強さで弱・中・強攻撃の使い分けができた。
ストリートファイターII(Wikipedia)…1991年にカプコンが発売したアーケード対戦格闘ゲーム。現在の格闘ゲームの基礎を作り、爆発的なヒットを記録した。
餓狼伝説(Wikipedia)…1991年にSNKが発売した対戦格闘ゲーム。以降餓狼シリーズはSNKの看板シリーズの一つとなる。初代餓狼伝説の主人公はテリー・ボガード、アンディ・ボガード、ジョー・ヒガシの三人。
龍虎の拳(Wikipedia)…1992年にSNKが発売した対戦格闘ゲーム。ゲージシステム、超必殺技、乱舞技など画期的なシステムが導入された。あと脱衣K.O。
キング・オブ・ファイターズ(KOF)シリーズ…SNKの格闘ゲーム。SNKを代表するキャラクター達が一堂に会し、チーム戦の勝ち抜き形式で戦う。格闘ゲームにおけるお祭りゲーやクロスオーバー系のゲームの元祖であると思われる。
NEOGEO(Wikipedia)…SNKがかつて販売していたゲーム機。アーケードと家庭で互換性があるのがウリだった。多くの名作ゲームがNEOGEOで稼働していた。
NEOGEO mini…ネオジオのソフトを40本（バージョンにより若干の差異あり）収録！往年の名作がいつでも遊べる！！HDMI接続でテレビに出力可能・アーケードコントローラーも接続可能！！coelaはもちろん買いました。
Behind the Curve, Netflix…Flat earth theoryを信じる人々のNetflixが作成したドキュメンタリー。下らない馬鹿げた人々が唱える説、というありがちな視点ではなく認知のバイアスは誰にでもありうる、というメッセージがとてもよい。
地球平面協会 (Flat Earth Society) (Wikipedia)
Flat Earth Society
2019-10-131h 10Global Venturing Review26 August 2019 – Uhuru Plans to File for an IPOExits
Uhuru to connect to UK’s public markets
Pfizer spinoff Springworks is developing drug treatments for rare forms of cancer, and has filed to raise up to $115m in an initial public offering that would also allow GlaxoSmithKline to exit.
Medical research tool developer 10x Genomics has already reached unicorn status, having closed a SoftBank-backed series D round that valued it at almost $1.3bn earlier this year. Business is going well for 10x, which more than doubled its revenue in 2018, and which has now filed for a $100m initial public offering.
IGM...
2019-08-2608 min
Wharton Business Radio Guest AudioSerge Saxonov on Launch PadSerge Saxonov, Founder and CEO of 10x Genomics, joins host Karl Ulrich on Launch Pad. See acast.com/privacy for privacy and opt-out information.
2019-05-1153 min
This Week in EvolutionFly by virusNels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Virus in fungus in fly (bioRxiv) On a leaf, no one can hear you scream (TWiV 443) Nels gives Benzer Lecture (YouTube) Domestication of fungal fly pathogen (bioRxiv) Sequencing E. muscae genome (10X genomics) Eisen's twitter stream on new iflavirus (Twitter) Science Picks Nels - Mindsuckers; getting photos; Anand Varma photos Vincent - Happy Birthday Gregor Mendel Music on T...
2018-07-251h 20
TechNation Health PodcastEpisode 18-27 The current limits of decoding our entire genomes and what can be doneOn Tech Nation Health, Chief Correspondent Dr Daniel Kraft brings 3D printing into healthcare – there’s a lot of value there – far more than printing cute little widgets just for fun. And Dr. Serge Saxonov, CEO of 10x Genomics, explains how our current technology for decoding our genomes has its limits, and how to can be improved upon.
2018-07-0319 min
BioTech Nation Radio PodcastEpisode 18-27 The Science of “Popular” vs. “Likable”
On this week’s Tech Nation, Moira speaks with Dr. Mitch Prinstein, a professor of psychology and neuroscience at the University of North Carolina, Chapel Hill. There’s a science to being popular – and a proven path to likability. Then on Tech Nation Health, Chief Correspondent Dr Daniel Kraft brings 3D printing into healthcare – there’s a lot of value there – far more than printing cute little widgets just for fun. And Dr. Serge Saxonov, CEO of 10x Genomics, explains how our current technology for decoding our genomes has its limits, and how to can be improved upon.
2018-07-0359 min
Mendelspod PodcastWe've Become Too Single Variant Centric, Says Deanna Church on Genome AnalysisFrom 1999 to 2013, Deanna Church was a staff scientist at the NCBI where, for a time, she headed the Genome Reference Consortium. This was the effort to continually update, improve and maintain the reference genome. Then Deanna went into private industry, first to Personalis--a genome interpretation company, and now she’s Director of Applications at 10X Genomics--the tools company offering linked read sequencing technology. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe
2017-10-1222 min