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The MicrobiomeResearchX (MRX) PodcastKazuki Nagashima: Grand Prize winner of the 2024 NOSTER & Science Microbiome PrizeOur guest today is Kazuki Nagashima at Stanford University, who is the grand prize winner of the 2023 NOSTER & Science Microbiome Prize for his essay entitled "Blockbuster T cells in the gut: A high-resolution view of immune modulation by the gut microbiome is presented.” Details about the prize-winning essaywww.science.org/doi/10.1126/science.adq2335Kazuki NagashimaBlockbuster T cells in the gut: A high-resolution view of immune modulation by the gut microbiome is presented. Science385,36-37(2024).DOI:10.1126/science.adq23352024-12-1312 minThe MicrobiomeResearchX (MRX) PodcastBrittany Needham: Finalist of the 2024 NOSTER & Science Microbiome PrizeOur guest today is Brittany Needham at Indiana University who is a finalist of the 2024 NOSTER & Science Microbiome Prize for his essay entitled " Exposed wires: A microbial metabolite influences myelination in the brain.” Details about the prize-winning essaywww.science.org/doi/10.1126/science.adq2344Brittany Needham Exposed wires: A microbial metabolite influences myelination in the brain. Science 385,37-37(2024). DOI:10.1126/science.adq23442024-12-1310 minThe MicrobiomeResearchX (MRX) PodcastLina Yao：Finalist 2024 2024 NOSTER & Science Microbiome PrizeOur guest today is Lina Yao at Harvard Medical School who is a finalist of the 2024 NOSTER & Science Microbiome Prize for his essay entitled " Breaking boundaries: Bacteria act as architects of host T cell modulators using bile acids.” Details about the prize-winning essaywww.science.org/doi/10.1126/science.adq2341Lina Yao Breaking boundaries: Bacteria act as architects of host T cell modulators using bile acids.Science385,37-37(2024).DOI:10.1126/science.adq23412024-12-1317 min
Kanazawa University NanoLSI PodcastHigh speed atomic force microscopy studies provide insights into influenza A viral replicationD. Carlero et al, ACS Nano 2024, 18, 30, 19518–19527Researchers from Kanazawa University's NanoLSI, IMDEA Nanoscience, and CNB-CSIC studied influenza A replication using high-speed atomic force microscopy. They observed that recombinant ribonucleoprotein complexes (rRNPs) can undergo multiple transcription cycles, with RNA structure stability influencing synthesis rates. Their findings offer new insights into viral replication mechanisms and RNA synthesis regulation, opening doors for further research on gene expression control. NanoLSI Podcast website2024-11-2104 minKanazawa University NanoLSI PodcastAtomic force microscopy in 3DM.S. Alam et al, Small Methods 2024, 2400287Atomic force microscopy (AFM) was initially developed to visualize surfaces at nanoscale resolution. Researchers at WPI NanoLSI, Kanazawa University, have now extended AFM for 3D imaging, particularly for flexible nanostructures like carbon nanotubes. They demonstrated that dynamic mode AFM, which uses a vibrating tip, causes less friction and damage than static mode, making it ideal for imaging delicate biological systems like cells, organelles, and vesicles. NanoLSI Podcast website2024-10-2404 minKanazawa University NanoLSI PodcastSensing a biomarkerMadhu Biyani and colleagues at NanoLSI, Kanazawa University, have developed a sensitive and selective electrochemical biosensor for detecting the cancer biomarker ADAR1, using new aptamers. This cost-effective tool enables rapid ADAR1 detection in diluted samples, promising improved cancer prognosis and monitoring.NanoLSI Podcast website2024-09-2605 minKanazawa University NanoLSI PodcastExploring hydrogen peroxide eustress effects on cancer cells using microscopyYanjun Zhang, Yuri Korchev, and colleagues used hopping probe scanning ion conductance microscopy to study hydrogen peroxide eustress on colorectal cancer cells, revealing varying cell stiffness and gradients. Their findings could lead to new cancer and inflammatory disease therapies. NanoLSI Podcast website2024-08-2204 minKanazawa University NanoLSI PodcastBiochemical tails tell a story Mikihiro Shibata and collaborators used high-speed atomic force microscopy to study nucleosome dynamics. They found that nucleosomes without histone tails, particularly H2B and H3, showed increased sliding and DNA unwrapping. These findings highlight the importance of histone tails in chromatin stability and structure. NanoLSI Podcast website2024-07-2504 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Discovering the molecular recognition of technological solids by mutant self-assembling peptidesHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Japan, collaborating with Professor Sarikaya, Seattle, USA.The research described in this podcast was published in Small in February 2024Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/NanoLSI Podcast website2024-06-2808 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers observe the structural heterogeneity of a lipid scramblaseHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Holger Flechsig and Clemens Franz from WPI-NanoLSI, at Kanazawa University, in collaboration with Vincent Torre from the International School of Advanced Studies in Italy and former WPI-NanoLSI members Leonardo Puppulin and Arin Marchesi.The research described in this podcast was published in Nature Communications in January 2024Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers observe the structural heterogeneity of a lipid scramblaseResearchers...2024-05-2406 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: A novel role for S100A11 in focal adhesion regulationHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Tareg Omer Mohammed, You-Rong Lin, and Clemens M. Franz at the Nano Life Science Institute (WPI-NanoLSI), at Kanazawa University.The research described in this podcast was published in the Journal of Cell Science in January 2024.Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/A novel role for S100A11 in focal adhesion regulationResearchers at Kanazawa University report in the Journal...2024-05-1007 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers observe what ubiquitination hinges onResearchers observe what ubiquitination hinges on Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Hiroki Konno and Holger Flechsig at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University.The research described in this podcast was published in Nano Letters in December 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers observe what ubiquitination hinges onResearchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the f...2024-04-2606 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Chromatin Accessibility: A new avenue for gene editingChromatin Accessibility: A new avenue for gene editingHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari.The research described in this podcast was published in Nature Genetics in February 2024Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Chromatin Accessibility: A new avenue for gene editingIn a study recently published in Nature Genetics, researchers from Nano...2024-04-1204 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers predict protein placement on AFM substratesHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Romain Amyot, Noriyuki Kodera, and Holger Flechsig at the Kanazawa University NanoLSI.The research described in this podcast was published in Frontiers in Molecular Biosciences in November 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers predict protein placement on AFM substratesResearchers at Kanazawa University report in Frontiers in Molecular Biosciences a computational method to predict the placement of proteins on AFM s...2024-03-2205 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Sodium channel investigationSodium channel investigationHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Ayumi Sumino and Takashi Sumikama at the Kanazawa University NanoLSI.The research described in this podcast was published in Nature Communications in December 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Sodium channel investigationResearchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell...2024-03-0806 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers fix the chirality of helical proteinsResearchers fix the chirality of helical proteinsHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Naoki Ousaka, Mark J. MacLachlan and Shigehisa Akine at the Kanazawa University NanoLSI.The research described in this podcast was published in Nature Communications in October 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers fix the chirality of helical proteinsResearchers at Kanazawa University report in Nature Communications how they can control chirality i...2024-02-2205 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Genetic switches in tumor developmentGenetic switches in tumor developmentHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Masanobu Oshima at the Kanazawa University NanoLSI.The research described in this podcast was published in Cancer Research in November 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Genetic switches in tumor developmentResearchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß p...2024-02-0905 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers tune the speed of chirality switchingResearchers tune the speed of chirality switchingHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Shigehisa Akine at the Kanazawa University NanoLSI.The research described in this podcast was published in Science Advances in November 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers tune the speed of chirality switchingResearchers at Kanazawa University report in Science Advances how they can accelerate and decelerate chirality inversion in large cage...2024-01-2605 min
Our Future PodcastHe Raised $23M To Disrupt Manafactured Home InsuranceIn #27, Michael Sikand (@michaelsikand) and Simran Sandhu (@_simmy_) discuss the co-founders of Covertree: Adarsh Rachmale (25), Divyansh Sharma (25), and Rishie Modi (37). After the guys graduated college, they decided they wanted a startup idea that targeted Middle America and that tech was completely ignoring. They found it in the insurance tech space with their company CoverTree, which specializes in insuring manafactured homes (also known as pre-fab houses). So far they've raised $23M in total, notched partnerships with Blackstone and Rocket Mortgage for distribution, and now help insure hundreds of millions worth of property. Follow the show...2024-01-2427 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers identify the dynamic behavior of a key SARS-CoV-2 accessory proteinResearchers identify the dynamic behavior of a key SARS-CoV-2 accessory protein Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Richard Wong at Kanazawa University alongside Noritaka Nishida at Chiba University.The research described in this podcast was published in the Journal of Physical Chemistry Letters in September 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers identify the dynamic behavior of a key SARS-CoV-2 accessory protein Researchers at...2024-01-1206 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers define a nanopipette fabrication protocol for high resolution cell imagingResearchers define a nanopipette fabrication protocol for high resolution cell imagingHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Yasufumi Takahashi at the Kanazawa University NanoLSI.The research described in this podcast was published in Analytical Chemistry in August 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers define a nanopipette fabrication protocol for high resolution cell imagingResearchers at Kanazawa University report in Analytical Chemistry how t...2023-12-2205 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Hydration matters:The interaction patterns of water and oxide crystals revealedHydration matters: The interaction patterns of water and oxide crystals revealedTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Keisuke Miyazawa at the Kanazawa University NanoLSI.The research described in this podcast was published in Nanoscale in July 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Hydration matters: The interaction patterns of water and oxide crystals revealed.https://nanolsi.kanazawa-u.ac.j...2023-12-0804 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Ion channel block unraveledIon channel block unraveled Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takashi Sumikama at the Kanazawa University NanoLSI in collaboration with Katsumasa Irie from Wakayama Medical University and colleagues.The research described in this podcast was published in Nature Communications in July 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Ion channel block unraveledResearchers at Kanazawa University re...2023-11-2405 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Brain cancer linked to nuclear pore alterationsBrain cancer linked to nuclear pore alterations Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Masaharu Hazawa and Richard Wong at the Kanazawa University NanoLSI, alongside Mitsutoshi Nakada and colleagues at Kanazawa University.The research described in this podcast was published in Cell Reports in August 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Brain cancer linked to nuclear pore alterations 2023-11-1005 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Researchers define a protocol for narrow nanoneedle fabrication and high-resolution imaging of living cells using AFMResearchers define a protocol for narrow nanoneedle fabrication and high-resolution imaging of living cells using AFM Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takehiko Ichikawa and Takeshi Fukuma at the Kanazawa University NanoLSI.The research described in this podcast was published in STAR Protocols in September 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Researchers define a protocol for narrow nanoneedle fabrication an...2023-10-2705 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: High-speed atomic force microscopy takes on intrinsically disordered proteinsHigh-speed atomic force microscopy takes on intrinsically disordered proteins Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Toshio Ando at the Kanazawa University NanoLSI, alongside Sonia Longhi at Aix-Marseille University and CNRS in France.The research described in this podcast was published in Nature Nanotechnology in November 2020 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/High-speed atomic force microscopy takes on in...2023-10-1305 minThe MicrobiomeResearchX (MRX) PodcastChristoph A. Thaiss: Finalist of the 2023 NOSTER & Science Microbiome PrizeOur guest today is Christoph A. Thaiss the Microbiology Department of the Perelman School of Medicine at the University of Pennsylvania, who is a finalist of the 2023 NOSTER & Science Microbiome Prize for his essay entitled "A microbiome exercise: gut-brain connections drive the motivation to work out.” Details about the prize-winning essayhttps://www.science.org/doi/10.1126/science.adi6329Essay: A microbiome exerciseScience, 381, 6653, p. 38, 2023. DOI: 10.1126/science.adi6329Related research L. Dohnalová et al A microbiome-dependent gut-brain pathway regulates motivation for ex...2023-09-2719 minThe MicrobiomeResearchX (MRX) PodcastChristopher Stewart: Finalist of the 2023 NOSTER & Science Microbiome PrizeOur guest today is Christopher Stewart of the Translational and Clinical Research Institute at Newcastle University, who is a finalist of the 2023 NOSTER & Science Microbiome Prize for his essay entitled "Diet-microbe-host interaction in early life: breastmilk bioactives are important to infant microbiome.” Details about the prize-winning essayhttps://www.science.org/doi/10.1126/science.adi6318Essay: Diet-microbe-host interaction in early lifeScience, 381, 6653, p. 38, (2023)DOI: 10.1126/science.adi6318Related research C. J Stewart et al, Temporal development of the gut microbiome in earl...2023-09-2712 minThe MicrobiomeResearchX (MRX) PodcastSara Clasen: Grand Prize winner of the 2023 NOSTER & Science Microbiome PrizeOur guest today is Sara Clasen of the Max Planck Institute for Biology in Tübingen, Germany, who is the recipient of the 2023 NOSTER & Science Microbiome Grand Prize for her essay entitled, “The sound of silence”. Details about the prize-winning essayhttps://www.science.org/content/page/2023-noster-science-prize-winnersEssay: The sound of silenceScience, 381, 6653, pp. 37-38, 2023DOI: 10.1126/science.adi6265Related research Clasen SJ, Bell MEW, Borbón A, Lee DH, Henseler ZM, de la Cuesta-Zuluaga J, Parys K, Zou J, Wang Y...2023-09-2716 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Heat and manipulate, one cell at a timeKanazawa University NanoLSI Podcast:Heat and manipulate, one cell at a time Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Satoshi Arai at the Kanazawa University NanoLSI.The research described in this podcast was published in ACS Nano in June 2022Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Heat and manipulate, one cell at a timeResearchers at Kanazawa University report in ACS N...2023-09-2205 minKanazawa University NanoLSI PodcastXiabing Lyu: Exosomes to regulate the human immune systemXiabing Lyu: Exosomes to regulate the human immune system (Kanazawa/ Recorded in June 2023) Xiabing Lyu is an Assistant Professor at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University. Here, she describes her research on engineering exosomes that regulate anti-viral and anti-tumor immune system responses. Details here: https://nanolsi.kanazawa-u.ac.jp/en/about/members/life-science/ The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University. The Nano...2023-09-0813 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Endoscopy of a Living Cell on the NanoscaleEndoscopy of a living cell on the nanoscale Transcript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takeshi Fukuma at the Kanazawa University NanoLSI. The research described in this podcast was published in Science Advances in December 2021 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Endoscopy of a living cell on the nanoscaleResearchers at Kanazawa University report in Science Advances a new technique for...2023-08-2505 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Enhancing carbon dioxide reductionKanazawa University NanoLSI Podcast: Enhancing carbon dioxide reductionTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Yasafumi Takahashi at the Kanazawa University NanoLSI and Yoshikazu Ito and Yuta Hori at the University of Tsukuba.The research described in this podcast was published in ACS Nano in June 2023Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Enhancing carbon dioxide reductionResearchers at...2023-07-2805 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Experiments provide insights into the molecular mechanism for memory and learningKanazawa University NanoLSI Podcast: Experiments provide insights into the molecular mechanism for memory and learning Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Mikihiro Shibata at the Kanazawa University NanoLSI alongside Hideji Murakoshi at The Graduate University for Advanced Studies and the National Institute for Physiological Sciences, and their colleagues.The research described in this podcast was published in Science Advances in June 2023Kanazawa University NanoLSI websitehttps://nanolsi...2023-07-1406 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Zooming in on neurotoxic aggregatesKanazawa University NanoLSI Podcast:Zooming in on neurotoxic aggregatesTranscript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research led by Kenjiro Ono at the Kanazawa University NanoLSI. The research described in this podcast was published in Nano Letters in May 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/ Zooming in on neurotoxic aggregatesResearchers at Kanazawa University report in Nano Letters how high-speed atomic force micro...2023-06-2305 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Scanning probe simultaneously captures structural and ion concentration changesKanazawa University NanoLSI Podcast:Scanning probe simultaneously captures structural and ion concentration changesTranscript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research led by Yasufumi Takahashi and Takeshi Fukuma at the Kanazawa University NanoLSI. The research described in this podcast was published in the Journal of the American Chemistry Society Au in February 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Scanning probe simultaneously captures structural and ion concentration cha...2023-06-0805 minKanazawa University NanoLSI PodcastKanazawa Univesity NanoLSI Podcast:Dynamic 3D structure extraction from HS-AFM imagesKanazawa Univesity NanoLSI Podcast:Dynamic 3D structure extraction from HS-AFM imagesTranscript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Holger Flechsig and Toshio Ando at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Current Opinion in Structural Biology in April 2023 Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/ Dynamic 3D structure extraction from high-speed atomic force microscopy images By allowing...2023-06-0803 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast:Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1Kanazawa University NanoLSI Podcast:Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1Transcript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Ayumi Sumino at the Kanazawa University NanoLSI alongside Motoyuki Hattori at Fudan University in China, and their colleagues. The research described in this podcast was published in the journal Proceedings of the National Academy of Science in May 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/2023-06-0805 minKanazawa University NanoLSI PodcastKien Xuan NGO: Interdisciplinary research to address important problems in modern biologyKien Xuan NGO: Interdisciplinary research to address important problems in modern biologyAssistant Professor Kien Xuan Ngo is member of Toshio Ando’s Nanometrology group at the Kanazawa NanoLSI. In this podcast is describes his research on structural biology for clarifying the functions of cytoskeletal proteins—such as actin and microtubules—and so-called ‘ABC transporters’. He is combining his expertise in biochemistry, biophysics, and mathematical simulations to address important problems in modern biology. The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University...2023-03-0920 minKanazawa University NanoLSI PodcastHolger Flechsig: Computational biophysics to visualize the dynamics of proteinsHolger Flechsig: Computational biophysics to visualize the dynamics of proteins Assistant Professor Holger Flechsig is a member of the Computational Molecular Physics group at the NanoLSI WPI Kanazawa University. Here he describes his research on answering the questions, “How do proteins work.” Specially, on molecular machines and motors, protein allostery, proteins interactions and cellular scale phenomena using multi-scale molecular dynamics simulations that enable us to produce molecular movies to visualize the dynamic motion of proteins. The Kanazawa University NanoLSI Podcast offers updates of the latest news and rese...2023-03-0820 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: The offshoot of cells visualized in real timeKanazawa University NanoLSI Podcast: The offshoot of cells visualized in real timeTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Richard Wong and colleagues at the Kanazawa University NanoLSI. The research described in this podcast was published in the Journal of Extracellular Vesicles, in November 2022 Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/The offshoot of cells visualized in real timeIn a stu...2023-02-0204 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Chemists uncover cracks in the amour of cellulose nanocrystalsKanazawa University NanoLSI Podcast: Chemists uncover cracks in the amour of cellulose nanocrystalsTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takeshi Fukuma and colleagues at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Science Advances in October 2022Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/Chemists uncover cracks in the amour of cellulose nanocrystalsChemists in...2023-01-0403 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Biological lasso: Enhanced drug delivery to the brainKanazawa University NanoLSI Podcast: Biological lasso: Enhanced drug delivery to the brainTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Kunio Matsumoto and colleagues at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Nature Biomedical Engineering in November 2022 Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/Biological lasso: Enhanced drug delivery to the brainIn a stu...2023-01-0405 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Simulating 3D-AFM images for systems not in equilibriumKanazawa University NanoLSI Podcast: Simulating 3D-AFM images for systems not in equilibriumTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takeshi Fukuma and his co-researchers at the Kanazawa University NanoLSI. The research described in this podcast was published in the Journal of Physical Chemistry Letters in June 2022Learn more about their research at the WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/ ...2022-12-0304 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Elucidating the structure of nanomaterials found in crustaceansKanazawa University NanoLSI Podcast: Elucidating the structure of nanomaterials found in crustaceansTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Ayhan Yurtsever and Takeshi Fukuma at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Small Methods in June 2022Kanazawa University NanoLSI website https://nanolsi.kanazawa-u.ac.jp/en/Elucidating the structure of nanomaterials found in crustaceansIn a st...2022-12-0304 minThe MicrobiomeResearchX (MRX) PodcastJennifer Hampton Hill: Grand Prize winner of the 2022 NOSTER & Science Microbiome PrizeOur guest today is Jennifer Hampton Hill, University of Utah is the recipient of the 2022 NOSTER & Science Microbiome Grand Prize for her work that “revealed that the resident microbiome is a promising source of previously undiscovered modulators of host β cells.”Links to details about the prize-winning essayhttps://www.science.org/content/page/2022-noster-science-prize-winnersEssay: From bugs to β cellsSCIENCE, 7 Jul 2022, Vol 377, Issue 6602, pp. 164-165 DOI: 10.1126/science.abq6051https://www.science.org/doi/10.1126/science.abq6051Latest research Jennifer Hampton Hill, Michelle Sconce...2022-11-0517 minKanazawa University NanoLSI PodcastHanae Sato: Research on molecular biology and “making sense of nonsense” (Kanazawa/ Recorded in October 2022) Hanae Sato is an Associate Professor at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University. Here, she describes her research on molecular biology and clarifying cellular quality control mechanisms of nonsense-mediated messenger RNA decay and potential therapeutic applications.Details here: https://nanolsi.kanazawa-u.ac.jp/en/research/researchers/hanae-sato/The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University.The Nano Life Science Institute (NanoLSI) at Kanazawa University was established in 2017 as part of the World Premier International (WPI) Res...2022-11-0114 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Heat and manipulate, one cell at a timeKanazawa University NanoLSI Podcast: Heat and manipulate, one cell at a timeTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Satoshi Arai and his co-researchers at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal ACS Nano, in June 2022Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/ Original article 2022-11-0105 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Chemical fixation causes aggregation artefactKanazawa University NanoLSI Podcast: Chemical fixation causes aggregation artefactTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Takehiko Ichikawa and his co-researchers at the Kanazawa University NanoLSI. The research described in this podcast was published in the journal Communications Biology, in May 2022.Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/Original article ...2022-11-0103 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Biomolecular insights into protein-insolubility-related diseaseTranscript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Rikinari Hanayama from the Kanazawa University NanoLSI and colleagues. The research described in this podcast was published in the Frontiers in Molecular Biosciences in March 2022.Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/ReferenceHiroki Yamaguchi, Hironori Kawahara, Noriyuki Kodera, Ayanori Kumaki, Yasutake Tada, Zixin Tang, Kenji Sakai, Kenjiro O...2022-10-0205 minKanazawa University NanoLSI PodcastKanazawa University NanoLSI Podcast: Promising anticancer molecule identifiedTranscript of this podcast Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Madhu Biyani from the Kanazawa University NanoLSI and her colleagues. The research described in this podcast was published in the ACS Applied Materials & Interfaces, in April 2022.Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/Original article Madhu Biyani etal Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Act...2022-10-0205 minKanazawa University NanoLSI PodcastKanazawa NanoLSI Research Podcast: Changing the handedness of molecules24 August 2022 Changing the handedness of molecules Researchers at Kanazawa University report in the Proceedings of the National Academy of Sciences a responsive molecular system that, inverses its chirality before becoming racemic through chemical reactions.Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/Transcript of this podcastHello and welcome to the NanoLSI podcast. In this episode we will feature the latest research published by Shigehisa Aki...2022-08-2404 minKanazawa University NanoLSI PodcastKanazawa NanoLSI Research Podcast: Revealing atomistic structures behind AFM imaging Revealing atomistic structures behind AFM imaginghttps://nanolsi.kanazawa-u.ac.jp/en/achievements/revealing-atomistic-structures-behind-afm-imaging/Atomic force microscopy (AFM) enables the visualization of the dynamics of single biomolecules during their functional activity. However, all observations are restricted to regions that are accessible by a fairly big probing tip during scanning. Hence, the AFM only records images of biomolecular surfaces with limited spatial resolution, thereby missing important information that is required for a detailed understanding of the observed phenomena.To facilitate the interpretation of experimental imaging, Romain Amyot and Holger Flechsig f...2022-08-2403 minKanazawa University NanoLSI PodcastKanazawa NanoLSI Research Podcast: Small but mighty: Identifying nanosized molecules using atomic force microscopyKanazawa NanoLSI Research Podcast 26 May 2022 Small but mighty: Identifying nanosized molecules using atomic force microscopy In a recent study Mikihiro Shibata and Leonardo Puppulin at the WPI Nano Life Science Institute Kanazawa University (NanoLSI) used advanced atomic force microscopy to accurately recognize tiny cellular biomolecules. Learn more about their research here: WPI Kanazawa Nano Life Science Institutehttps://nanolsi.kanazawa-u.ac.jp/en/research/researchers/Original article: https://pubs.acs.org/doi/10.1021/acsami.1c17708Transcript of this podcast2022-05-2606 minKanazawa University NanoLSI PodcastProfessor Toshio Ando: Publication of an insightful reference book on high-speed atomic force microscopy (HS-AFM) for in situ biological applicationsKanazawa University research: Publication of an insightful reference book on high-speed atomic force microscopy (HS-AFM) for in situ biological applications Pioneering biophysicist Professor Toshio Ando of the NanoLSI publishes his new book on high-speed atomic force microscopy (HS-AFM) for directly monitoring the dynamics of biomolecules. The book offers easy to understand descriptions of the basic technology and in situ biological applications of liquid HS-AFM. The book is ideal for students from multidisciplinary backgrounds interested in accelerating their research on high speed, in situ monitoring of biomolecules. NanoLSI Podcast where Professor Ando describes the ba...2022-05-0717 minKanazawa University NanoLSI PodcastShigehisa Akine and Mark J. MacLachlan: Nanomolecular cages for biomolecular sensing and AFM tips for chemically probing living cells. (Recorded 15 March 2022, JST)Professor Shigehisa Akine is a principal investigator at the NanoLSI WPI Kanazawa University. Professor Mark MacLachlan is an overseas principal investigator at the NanoLSI WPI Kanazawa University and faculty at the University of British Columbia. In this episode of the NanoLSI Podcast they describe recent developments in their research on nanomolecular cages for biomolecular sensing and biocompatible AFM tips for chemically probing living cells, respectively.The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University for a global audience.The Nano Life Science Institute (NanoLSI) a...2022-05-0318 minKanazawa University NanoLSI PodcastCarsten Beta: Research on biological physics on the scale of individual cells based on nanomicroscopic manipulation and pattern formation in nonlinear systems (Potsdam/ Recorded on 18 March 2022)Professor Carsten Beta is an overseas-based principal investigator at the NanoLSI WPI Kanazawa University and faculty at the Universität Potsdam Institute of Physics and Astronomy, University of Potsdam, Germany. Here, he describes his research on biological physics on the scale of individual cells based on microscopic observations and manipulation and modelling using pattern formation in nonlinear systems.The Kanazawa University NanoLSI Podcast offers updates of the latest news and research at the WPI-NanoLSI Kanazawa University.The Nano Life Science Institute (NanoLSI) at Kanazawa University was established in 2017 as part of the World Pr...2022-05-0322 minThe MicrobiomeResearchX (MRX) PodcastEran Blacher: Grand Prize winner of the 2021 NOSTER & Science Microbiome PrizeOur guest today is Eran Blacher, who is currently a senior postdoctoral fellow at Stanford School of Medicine studying the immune system-gut-brain axis in ageing and neurological disorders. Eran is the Grand Prize winner of the 2021 NOSTER & Science Microbiome Prize for his essay, “Can microbes combat neurodegeneration?” based on his research on the relationship between the microbiome and neurodegenerative diseases such as Alzheimer's disease.Links to details about the prize-winning essay are available on the MicrobiomeResearchX (MRX) website and related AAAS sites. MRX website https://noster-mrx.net/Summary of the res...2021-11-1720 minThe MicrobiomeResearchX (MRX) PodcastErez Baruch: Finalist of the 2021 NOSTER & Science Microbiome PrizeOur guest today is Erez Baruch, who recently started an internal medicine residency in a research (Physician-Scientist) track to medical oncology. Internal medicine training is conducted at the McGovern Medical School in Houston, Texas.Erez is a finalist of the 2021 NOSTER & Science Microbiome Prize for his essay, "Microbiota modulation to fight cancer”, based on his research on “mechanisms of immunotherapy resistance and toxicity, modulation of the gut microbiota, and interaction between innate and adaptive immune cells”. Links to details about the prize-winning essay are available on the Noster Inc MicrobiomeResearchX (MRX) website and related AAAS Science...2021-11-1720 min