Shows
Too Young For This Sh*t with Allie SignorelliKatie CouricI mean...do we even need a description here? My sit down with the legendary news icon Katie Couric. We talked all about Parkinson's and a million other things that I can't even really remember because I am pretty sure I blacked out for most of this conversation. What I do know is that she is hysterical and generous and I am lucky to know her.
2025-12-1431 min
On Time: A Parkinson's PodcastPermission to PlayLife After a Parkinson's DiagnosisEpisode 1: Permission to PlayGuests: Kevin Kwok, Bill Buckalew, Yvonne Jackson, Dr. Anne Cohn Donnelly, Margaret Burns-Kohn, Allie Signorelli, Jimmy Choi, Michael Fitts, Kuhan Pushparatnam, Dan DumshaCreativity often blooms in unexpected soil. In this episode, Larry talks with a wide range of people who discovered (or rediscovered) their creative side after a Parkinson’s diagnosis. From painting to photography, improv to boxing, their stories prove that Parkinson’s doesn’t end your story — it gives you a new chapter. Hear how creativi...
2025-10-0627 minOn Time: A Parkinson's PodcastPermission to FlyLife After a Parkinson's DiagnosisEpisode 2: Permission to FlyGuests: Kevin Kwok, Bill Buckalew, Yvonne Jackson, Allie Signorelli, Jimmy Choi, Michael Fitts, Richard & Angela Huckabee, Dr. Anne Cohn Donnelly, Margaret Burns-KohnParkinson’s might slow you down — but it doesn’t have to keep you grounded. In this episode, Larry shares tips, tricks, and hilarious travel tales from seasoned globetrotters with Parkinson’s. From TSA turbulence to time-zone medication math, these guests share how they prep, pack, and power through. Whether you’re flying international or road-tripping local, you...
2025-10-0625 minOn Time: A Parkinson's PodcastPermission to PivotLife After a Parkinson's DiagnosisEpisode 3: Permission to PivotGuests: Kevin Kwok, Bill Buckalew, Yvonne Jackson, Jimmy Choi, Allie Signorelli, Michael Fitts, Dr. Michael Okun, Deena Grinnell, Margaret Burns-Kohn, Richard HuckabeeLiving with Parkinson’s is a masterclass in adaptation. In this episode, Larry and his guests share the big and small pivots that make everyday life a little easier—from mobility hacks to medication workarounds, wardrobe upgrades to home safety tweaks. You’ll learn why “pivoting” isn’t giving up—it’s choosing a smarter path forward. As one...
2025-10-0626 minOn Time: A Parkinson's PodcastPermission to LaughLife After a Parkinson's DiagnosisEpisode 4: Permission to LaughGuests: Matt Eagles, Margaret Burns-Kohn, Dr. Anne Cohn Donnelly, Richard & Angela Huckabee, Kevin Kwok, Bill Buckalew, Yvonne Jackson, Jimmy Choi, Allie Signorelli, Michael FittsLaughter won’t cure Parkinson’s — but it might just help you live with it. In this heartfelt and hilarious finale, Larry explores the power of humor with people who’ve learned to laugh with Parkinson’s, not at it. From awkward urology visits to naming your disease “Earl,” the episode is full of honest moments...
2025-10-0627 min
Too Young For This Sh*t with Allie SignorelliDr. Dorsey & Dr. Okun - The Parkinson's PlanJoin me and Dr. Ray Dorsey and Dr. Michael Okun as we chat about their New York Times bestselling book The Parkinson's Plan which lays out a path forward to ending this awful disease. It's not all science and confusion though - we laugh a lot and talk about ways people can save their brains.
In The Parkinson’s Plan, the docs show readers how to prevent the disease through the food we eat, the water we drink, the air we breathe, and the lifestyles we live. They introduce the “Parkinson’s 25,” the most detailed checklist ever created t...
2025-08-1444 min
MeSsy with Christina Applegate & Jamie Lynn SiglerHow to Make Your Own Community with Allie SignorelliThis week, Christina and Jamie are joined by Allie Signorelli, a Young Onset Parkinson’s patient and advocate. They discuss her journey to getting diagnosed, the importance of being honest, paying attention to symptoms, finding gratitude, and more.Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison BresnickAudio Engineer: Josh WindischThis show is sponsored by:Mudwtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at mudwtr.com/messy #mudwtrpodCalm - Stress less, sleep more, and l...
2025-02-251h 11
Too Young For This Sh*t with Allie SignorelliAi-jen PooJoin me as I chat with the amazing Ai-jen Poo who has been recognized among Fortune’s 50 World’s Greatest Leaders and Time’s 100 Most Influential People in the World, and she has been the recipient of countless awards, including a 2014 MacArthur "Genius" Award. Ai-jen has been a featured speaker at TEDWomen, Aspen Ideas Festival, Cannes Lions Festival of Creativity, Skoll World Forum, and the Obama Foundation Inaugural Summit.
2024-11-2543 min
Too Young For This Sh*t with Allie SignorelliLauren Miller RogenA conversation with producer, actress, writer, director and nonprofit founder Lauren Miller Rogen who started Hilarity for Charity (HFC) with her husband Seth Rogen. Lauren lost her mom to early onset Alzheimer's and created HFC to bring light to the disease and to support caregivers.
Lauren shares her mom's story and the incredible work HFC is doing today to educate the next generation about the importance of brain health.
2024-10-1626 min
Too Young For This Sh*t with Allie SignorelliDr. Rachel DolhunDr. Rachel Dolhun is a double-board-certified neurology and lifestyle medicine physician and fellowship-trained movement disorder specialist, who joined The Michael J. Fox Foundation in 2014 to lead medical communication. This conversation is about being a woman with Parkinson's and all that that entails. Spoiler alert: PD is not the same experience for women as it is for men. Join us as we talk all things gals, brains and more!
2024-08-2713 min
The Secret Life of Parkinson's#115: A Young-onset Parkinson's advocate - Allie SignorelliIf you are on Instagram and have PD, you probably have seen, "imstillallie". Brian and I had the opportunity and priviledge to interview Allie Signorelli, a Young-onset PD powerhouse. Her career background happens to be in the non-profit space - doing events and fundraising for Alzheimer's. Even though she worked in the Neurodegenerative space as an advocate/event coordinator for years, she never expected to be a part of such a community. Allie was diagnosed with Young Onset Parkinson's - check out her story and the courageous work she is doing for the Parkinson's community! We appreciate all advocates...
2024-08-1941 min
Too Young For This Sh*t with Allie SignorelliDr. Michael OkunJoin me and Dr. Michael Okun, New York Times bestselling author of The Parkinson's Plan and He is a leading national spokesperson for Parkinson's disease, and has been extensively quoted in The New York Times, Wall St. Journal, USA Today, CNN and other media.
He is the former Chair of Neurology at the University of Florida. He is the co-founder and Executive Director of the Norman Fixel Institute for Neurological Diseases at the University of Florida Health. The Institute is unique in that it is comprised of more than 150 interdisciplinary faculty members from diverse areas o...
2024-06-2657 min
Too Young For This Sh*t with Allie SignorelliCongressman Gus BilirakisJoin me and Congressman Gus Bilirakis (R-FL) as we talk about the historic passing of the National Plan to End Parkinson's act which was named in honor of his brother Dr. Emmanuel Bilirakis who lived with Parkinson's disease. This was recorded shortly after President Biden signed the law to create the National Parkinson's Project in July 2024.
2024-06-2515 min
Power Over Parkinson'sRadiating Positivity while Advocating for Parkinson’sAllie Signorelli, Parkinson’s Advocate and person with young onset Parkinson’s (YOPD), shares her journey to diagnosis and how she’s positively impacting the Parkinson’s community at a national level. Allie is lending her voice through advocacy and harnessing her career experience, particularly in fundraising and event management, to serve our community and aid in research that’s related to both therapeutics as well as the cure that we are all hoping for! Allie is an inspiration to us all and our community is lucky to have her finding her “silver linings” as someone with YOPD. Support the s
2024-05-2043 min
Too Young For This Sh*t with Allie SignorelliDr. Ray DorseyDr. Ray Dorsey is a leading voice in Parkinson’s disease research and care, and a tireless advocate for rethinking how we approach chronic illness. A neurologist by training, he combines deep clinical experience with a passion for how technology can fuel health care innovation and change. “I knew I wanted to be a doctor in first grade,” says Dr. Dorsey, whose parents were both psychiatrists. “I’ve always loved learning and I still do.” Dr. Dorsey holds a Bachelor of Science in biological sciences from Stanford University, and a joint MD/MBA degree from the University of Pennsylvania Perelman Sch...
2024-04-1542 min
Too Young For This Sh*t with Allie SignorelliEmma Heming Willis & Helen ChristoniJoin me in a chat with the co-founders of Make Time Wellness, Emma Heming Willis and Helen Christoni. They share how their own personal journeys have informed this company designed to help women make their brains a priority.
2024-04-1538 min
Too Young For This Sh*t with Allie SignorelliSandra AbrevayaJoin me as I chat with my friend and the hardest working woman in the neurodegenerative space. Sandra is the wife and care partner to Brian Wallach who is living with ALS. They are the co-founders of I Am ALS and Synapticure. She is beautiful and honest about her caregiving journey and the pain of watching the person you love most in the world suffer. She has turned her pain into passion to make the world a better and more livable place for all.
2024-03-1844 min
Too Young For This Sh*t with Allie SignorelliDr. Richard IsaacsonJoin me in a conversation with my buddy Dr. Richard Isaacson who made me laugh so hard during this conversation - who knew geniuses where so funny! Dr. I and I talk about Parkinson's, brain health and prevention, memory and nutrition and our days as youngens at Northwestern (where I attended and he visited apparently but I didn't know it!).
Dr. Isaacson is a pioneering neurologist, he Founder and Former Director of the Alzheimer’s Prevention Clinic, a first-of-its-kind in the world, at Weill Cornell Medicine/New York Presbyterian, where he was also Assistant Dean of Faculty De...
2024-02-0838 min
Too Young For This Sh*t with Allie SignorelliDr. Julie FratantoniJoin me and Dr. Julie Fratantoni, a neuroscientist and brain health expert, as we discussed healthy habits for our heads. Julie received her PhD in Cognitive Neuroscience from The University of Texas at Dallas. she is a licensed Speech Language Pathologist, trained in biofeedback, a 200 hr certified yoga instructor and trained in breathing and mindfulness techniques. Here work focuses on how to improve brain performance and extend cognitive longevity.
2024-01-1842 min
Too Young For This Sh*t with Allie SignorelliDrew HatterJoin me as I chat with Drew Hatter, Senior Government Relations Manager at The Michael J. Fox Foundation about the National Plan to End Parkinson's Act. We filmed this in 2024 shortly before the National Plan became a law, now called the National Parkinson's Project.
2023-12-1240 min
Too Young For This Sh*t with Allie SignorelliAnnmarie O'ConnorJoin me in a conversation with the lovely and talented Irish Examiner columnist, stylist, author and podcaster Annmarie O'Connor. We talk about our shared journeys having young onset Parkinson's and overcoming the shock we felt after our diagnosis.
Annmarie wrote her memoir, Twitch which is a frank and funny memoir about picking up the pieces when personal tragedy hits. The book chronicles her journey from a life-altering diagnosis to becoming an activist and agent of change.
2023-12-1246 min
Too Young For This Sh*t with Allie SignorelliChristopher JacksonJoin me as I catch up with one of my oldest friends, Broadway and television star Christopher Jackson. Chris is best known for his iconic run as George Washington in Broadways' Hamilton. He's also a Daytime Emmy winner for his work on Sesame Street, voiced Chief Tui in Disney's Moana, and stars as Herbert Wexley in And Just Like That... with past TV roles including the CBS drama Bull. We talk about our days as in New York City, his career, and the experiences he and his wife Veronica have had raising their son CJ who was born with a...
2023-12-101h 01
Too Young For This Sh*t with Allie SignorelliJohn LehrJoin me as I chat with the CEO of the Parkinson's Foundation, John Lehr. We talk about the organization's mission and the critical role that they play in the lives of those of us living with this diseased. John L. Lehr leads the Parkinson's Foundation (PF) as president and chief executive officer. He has nearly three decades of nonprofit fundraising and management experience, with a strong focus in the voluntary healthcare and medical research sectors. Lehr played a key role in merging two legacy Parkinson’s disease (PD) organizations into the Parkinson’s Foundation in 2017. Since joining the Foundation, fund...
2023-11-0851 min
Too Young For This Sh*t with Allie SignorelliDr. Lisa GenovaJoin me as I chat with New York Times bestselling author and neuroscientist Dr. Lisa Genova. Acclaimed as the Oliver Sacks of fiction and the Michael Crichton of brain science, Lisa has captured a special place in contemporary fiction, writing stories that are equally inspired by neurological conditions and our shared human condition. She is the New York Times bestselling author of the novels STILL ALICE, LEFT NEGLECTED, LOVE ANTHONY, and INSIDE THE O'BRIENS.
2023-10-2048 min
Too Young For This Sh*t with Allie SignorelliBrooke EbyJoin Allie as she hosts her very first conversation with the one and only Brooke Eby. Diagnosed with ALS at just 33 years old. Brooke turned her devastating diagnosis into an opportunity to raise awareness using social media to share her her journey. She is hysterical and amazing in every way. The conversation covered everything from Bravo to Harry Potter to Tim McGraw songs. Come for the brain discussion, stay for her epic hair.
2023-10-1055 min