Shows
RadOnc Smart ReviewRadBio E37: G2/M Control (Wee1) & Apoptosis (Bcl-2/Caspases)Welcome back to Rad Onc Smart Review! This is Episode 37: G2/M Control (Wee1) & Apoptosis (Bcl-2/Caspases). In our previous episode, we explored the intricate mechanisms of G1/S checkpoint control, highlighting the roles of p53, p21, and the Rb/E2F pathway. Today, we shift our focus to another critical regulatory point, the G2/M transition, and then delve into the fascinating and highly regulated process of programmed cell death, or apoptosis. We'll examine how Wee1 kinase and Cdc25 phosphatases govern entry into mitosis, and then explore both the intrinsic (mitochondrial) and extrinsic (death receptor) pathways of apoptosis, paying...2025-05-3030 min
SAPIEN Podcast - Optimum Health & Wellness48) Why We Age & How to Reverse It – The Science of Apoptosis | Dr. Shohreh ErshadiWhy We Age & How to Reverse It – The Science of Apoptosis Can we slow down or even reverse aging? In this episode of the Sapien Podcast, we dive deep into the science of apoptosis—the body’s natural way of eliminating damaged cells to keep us healthy. Our guest, Dr. Shoreh Ershadi, CEO of Apoptosis Nutraceuticals, breaks down: ✅ What apoptosis is and why it’s critical for longevity ✅ How fasting can trigger cell regeneration and prevent disease ✅ The role of telomeres in aging and how to protect them ✅ The surprising link between inflammation and age-related diseases ✅ Supplements, peptides, and life...2025-03-1052 min
Ecléctica¿Qué es la Apoptosis?La Apoptosis es un proceso de muerte celular programada, esencial en el desarrollo y mantenimiento de un equilibrio (homeostasis) en los organismos.
A diferencia de la necrosis (muerte celular traumática que causa inflamación), la apoptosis es un mecanismo controlado y ordenado que elimina células innecesarias o dañadas sin dañar tejidos circundantes.
Conducen: Alejandro Rivera y José Gabriel Ávila.2025-02-1258 min
DeathlessApoptosis / Norah's Ark (with Hannah Altenbach)Send us a textWelcome to this mini episode of Deathless where we break down the latest headlines in the news about immortality. To help me, Pulitzer winning journalist from The Times... Hannah Altenbach.Main Story: ApoptosisGeneticists are exploring a new gene therapy that would program human cells to die all at once. In effect: a death virus. On the Lighter Side: Norah's ArkThe latest death alternative is a closed-loop cruise line designed specifically for the super elderly. Bon voyage, I guess?2024-12-1910 min
To Immunity and BeyondApoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosisProfessor Quentin Sattentau discusses research published in 'Nature Communications' on the role of enzyme ADAM10 in mediating clearance of apoptotic T cells by macrophages. This episode discusses Drexhage, LZ, Zhang, S, Dupont, M, et al. Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nat Commun. 15(1), 541 (2024). http://doi.org/10.1038/s41467-023-44619-8
Article funding and acknowledgments: https://www.nature.com/articles/s41467-023-44619-8#Ack1
Professor Sattentau thanks Linnea Drexhage and Shengpan Zhang (joint first authors) who worked really hard and provided most of the data, Niloofar Karaji who discovered the initial phenomenon, all the other...2024-11-0635 min
The Elephant: Hidden Truths in the Science of HealthCancer, Apoptosis, and Sugar Nutrients (272)Larry joins Angie to discuss a question that came in concerning how sugar nutrients relate to cancer. Larry explains the nature of specific sugars and how they impact the immune system. He discusses the metabolic process of apoptosis which relies on sugars to enable the immune system to detect and eliminate cancer cells. Tune In!2024-09-0215 min
The Leading DifferenceDr. Shoreh Ershadi | Founder, ANTIAGING Institute of California | Apoptosis, Clinical Excellence, & Women in ScienceDr. Shoreh Ershadi is the founder of ANITAGING Institute of California and a renowned expert in clinical biochemistry and pharmacology with over 40 years of experience. Dr. Ershadi shares her compelling journey from Iran to the United States, highlighting her unexpected entry into medical technology and the numerous challenges she faced as a woman in science. From setting up clinical labs and pioneering AIDS testing to founding her own antiaging company, Dr. Ershadi discusses her relentless pursuit of scientific innovation and passion for improving human health. The conversation also touches on her entrepreneurial ventures, the role of art in her...2024-08-2342 minThe Leading DifferenceDr. Shoreh Ershadi | Founder, ANTIAGING Institute of California | Apoptosis, Clinical Excellence, & Women in ScienceDr. Shoreh Ershadi is the founder of ANITAGING Institute of California and a renowned expert in clinical biochemistry and pharmacology with over 40 years of experience. Dr. Ershadi shares her compelling journey from Iran to the United States, highlighting her unexpected entry into medical technology and the numerous challenges she faced as a woman in science. From setting up clinical labs and pioneering AIDS testing to founding her own antiaging company, Dr. Ershadi discusses her relentless pursuit of scientific innovation and passion for improving human health. The conversation also touches on her entrepreneurial ventures, the role of art in her...2024-08-2342 min
The Melanie Avalon Biohacking Podcast#264 - Catharine Arnston: Spirulina Science, The Perfect Evolutionary Food, Mitochondrial Health, Superoxide Dismutase & Phycocyanin, ATP Production, Cancer Prevention, Apoptosis, Autophagy & Necroses, Nutrient Dense Vegan Protein, And More!GET TRANSCRIPT AND FULL SHOWNOTES: melanieavalon.com/spirulinaIF Biohackers: Intermittent Fasting + Real Foods + Life: Join Melanie's Facebook group for a weekly episode giveaway, and to discuss and learn about all things biohacking! All conversations welcome!Follow Melanie on Instagram to see the latest moments, products, and #allthethings! @melanieavalonAVALONX SPIRULINA: Spirulina is out now! AvalonX supplements are free of toxic fillers and common allergens (including wheat, rice, gluten, dairy, shellfish, nuts, soy, eggs, and yeast), tested to be free of heavy metals and mold, and triple-tested for purity and potency. Get on the email li...2024-08-231h 39
LifeBloodUnderstanding Apoptosis with Dr. Shoreh ErshadiLifeBlood: We talked about understanding apoptosis, how to grow older without aging, how our bodies are made up of over 30 trillion cells and how to cultivate their health, the role inflammation plays in our health, and how to be proactive about it, with Dr. Shoreh Ershadi Chief Medical Officer of Apoptosis Nutraceuticals, and Board Certified in AntiAging.
Listen to how to begin improving your life and health spans!
You can learn more about Shoreh at Apoptosis.US, and LinkedIn.
Thanks, as always for listening! If you got some value and enjoyed the show, please...2024-06-2725 min
CME in Minutes: Education in Oncology & HematologySue S. Yom, MD, PhD - Latest Updates in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: The Clinical Potential of Inhibitor of Apoptosis Protein (IAP) Antagonists to Change the Treatment LandscapePlease visit answersincme.com/PQD860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in squamous cell carcinoma of the head and neck (SCCHN) discusses the clinical potential of antagonists of inhibitor of apoptosis proteins (IAPs) for unresected, locally advanced SCCHN. Upon completion of this activity, participants should be better able to: Identify the rationale for investigating the use of antagonists of inhibitor of apoptosis proteins (IAPs) in the treatment of unresected locally advanced squamous cell carcinoma of the head and neck (LA SCCHN); Discuss the latest efficacy and safety...2024-03-0914 min
CME in Minutes: Education in Primary CareSue S. Yom, MD, PhD - Latest Updates in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: The Clinical Potential of Inhibitor of Apoptosis Protein (IAP) Antagonists to Change the Treatment LandscapePlease visit answersincme.com/PQD860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in squamous cell carcinoma of the head and neck (SCCHN) discusses the clinical potential of antagonists of inhibitor of apoptosis proteins (IAPs) for unresected, locally advanced SCCHN. Upon completion of this activity, participants should be better able to: Identify the rationale for investigating the use of antagonists of inhibitor of apoptosis proteins (IAPs) in the treatment of unresected locally advanced squamous cell carcinoma of the head and neck (LA SCCHN); Discuss the latest efficacy and safety...2024-03-0914 min
The Clueless DoctorApoptosisA kind of programmed cell death, apoptosis is very vital for normal functioning of the body.2023-10-0124 min
Lions4ScienceCellular Death: Apoptosis and Cytochrome C + The Many Ways Cells Can Meet Their Untimely Demise(w/Expert Ron Jemmerson)The long( a hot week) awaited episode on the death of cells and all things holy. Jk, but for real if you thought this episode was interesting check out the research my interviewee had[One of Ron's many research articles https://rdcu.be/cW75R , https://link.springer.com/article/10.1007/s10495-020-01647-9#citeas].
This episode focuses on the forms of celluar death, it's reason for survival, and the mechanisms that make it work. Enjoy!!
Sources
https://youtu.be/-vmtK-bAC5E (What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade)
https://youtu.be/luR6mLnMOwg(Cytochrome C, The M...2023-10-0149 min
Med TogetherApoptosisHi Everyone!
Hope you enjoy this final installment in the cell biology series where we discuss cell death, focusing on non-lytic cell death represented by apoptosis. As always, please rate and share the show and I'll see you back for the metabolism series coming soon!2023-09-2417 min
Dog Cancer AnswersApoptosis Explained Simply and Why It Matters in Dog Cancer | Amanda Kin, M.S.Enter the fascinating world of cell death, where nosy neighbors can tell each other to “die, already” … and cells can wake up one day and realize there’s something very, very wrong.Also learn how cancer manipulates the conscientious cells to make them blissfully unaware of their own wrongdoing … or holds them hostage while they desperately, desperately try to do the right thing and kill themselves for the good of everyone.It’s a glimpse into a world where cells seem sentient, and one could almost start to believe in miracles.Links Mentioned in Today’s S...2023-09-0432 minCME in Minutes: Education in Primary CareJonathan Schoenfeld, MD, MPH - Evolving the Treatment Landscape in Head and Neck Squamous Cell Carcinoma: Promoting Apoptosis With Emerging Antagonists of Inhibitors of Apoptosis ProteinsPlease visit answersincme.com/EEF860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in head and neck squamous cell carcinoma (HNSCC) discusses the clinical significance of emerging antagonists of inhibitors of apoptosis proteins (IAPs) for patients with HNSCC. Upon completion of this activity, participants should be better able to: Describe the biologic rationale for emerging antagonists of IAPs for patients with resectable and unresectable locally advanced (LA) HNSCC; Review the clinical significance of emerging antagonists of IAPs in the treatment of unresectable LA HNSCC, based on the latest efficacy...2023-06-0114 minCME in Minutes: Education in Oncology & HematologyJonathan Schoenfeld, MD, MPH - Evolving the Treatment Landscape in Head and Neck Squamous Cell Carcinoma: Promoting Apoptosis With Emerging Antagonists of Inhibitors of Apoptosis ProteinsPlease visit answersincme.com/EEF860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in head and neck squamous cell carcinoma (HNSCC) discusses the clinical significance of emerging antagonists of inhibitors of apoptosis proteins (IAPs) for patients with HNSCC. Upon completion of this activity, participants should be better able to: Describe the biologic rationale for emerging antagonists of IAPs for patients with resectable and unresectable locally advanced (LA) HNSCC; Review the clinical significance of emerging antagonists of IAPs in the treatment of unresectable LA HNSCC, based on the latest efficacy...2023-06-0114 min
OncotargetRole of Pyrethroid Derivatives in Autophagy and Apoptosis Crosstalk SignalingA new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies.”
Pyrethroids are extensively used insecticides by virtue of insecticidal activity potential in Asia, especially India, and in different nations worldwide to counter mosquitoes and insects for household or agricultural needs. The continuous widespread and uncontrolled use of pyrethroids and its derivatives have influenced multiple deleterious effects resulting in a potential risk factor causing damage to organ systems. Allethrin and prallethrin are extensively used, yet their influences on human primary cells are very limi...2023-01-0304 min
DJ Matthias (BELGIUM)- Vinylsets & ProductionsApoptosisDJ Matthias - Apoptosis2023-01-0107 min
Dr VK Physiology ClassesApoptosisApoptosis2022-12-0913 min
The Healthy Mouth Movement PodcastApoptosisHave you heard about Apoptosis? Are you aware of this very important function that happens in our bodies at the very cellular level, and the impact it has on your health? Apoptosis is a form of programmed cell death that occurs naturally in our bodies. It helps keep our cells healthy and functioning, allowing them to live longer and work more efficiently. When apoptosis isn’t working properly, it can cause serious health problems, such as cancer and other diseases. Most people don't know this, but at the cellular level of our body, there is som...2022-12-0524 min
Stay Current in Pediatric SurgeryRapamycin Induces Autophagy And Apoptosis In Kaposiform Hemangioendothelioma Primary Cells In VitroListen to Zuopeng Wang gave his presentation of "Rapamycin Induces Autophagy And Apoptosis In Kaposiform Hemangioendothelioma Primary Cells In Vitro" at the first ever Best of the Best in Pediatric Surgery event.2022-11-1909 minCME in Minutes: Education in Oncology & HematologyBarbara Burtness, MD - Rethinking Therapeutic Strategies for Squamous Cell Carcinoma of the Head and Neck: Promoting Apoptosis with Emerging TherapiesPlease visit answersincme.com/XRU860 to participate, download slides and supporting materials, complete the post test, and obtain credit. In this activity, an expert in head and neck carcinoma discusses unmet therapeutic needs in squamous cell carcinoma of the head and neck and the potential impact of inhibitor of apoptosis proteins on treatment. Upon completion of this activity, participants should be better able to: Recognize the unmet therapeutic needs of patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN); Describe the rationale for targeting inhibitor of apoptosis proteins (IAPs) in the development of novel therapies...2022-08-1013 min
OncotargetPress Release: CUDC907 Promotes Apoptosis Of NF2 Schwannoma CellsA new research paper was published in Oncotarget on July 19, 2022, entitled, “CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells.”
Neurofibromatosis Type 2 (NF2) is a rare tumor disorder caused by pathogenic variants of the merlin tumor suppressor encoded by NF2. Patients develop vestibular schwannomas (VS), peripheral schwannomas, meningiomas, and ependymomas. There are no approved drug therapies for NF2. Previous work identified phosphoinositide-3 kinase (PI3K) as a druggable target.
Researchers Julianne Huegel, Christine T. Dinh, Maria Martinelli, Olena Bracho, Rosa Rosario, Haley Hardin, Michael Estivill, Anthony Griswold, Sakir Gultekin, Xue-Zhong Liu, and Cristina Fernandez-Valle, from the...2022-07-2605 min
Friday Night DeathApoptosisIntrinsic Pathways
Friday Night Death with Konk Zooben live streams every Friday at 11.00pm AEST
Watch or listen: www.fridaynightdeath.com/apoptosis2022-03-0418 min
TinotalksReal life apoptosisapoptosis come true2022-01-2717 min
Spin It!Apoptosis - Inner Wave: Episode 21For our first listener-recommended episode James and Connor are going on a trip through Inner Wave's new album, Apoptosis! Through concise, vivid-yet-indirect lyrics, the record explores loss, memory, time, and longing in a way that few others can. From the first punchy "wah" hook of One In A Million to the final lyrical gut-punch of Bones, Inner Wave will catch your ear with a release that's full of heart (oh, and the Mixtaper brought yo-yo facts this week). Check it out in this episode, and thank YOU for the recommendation!Keep Spinning at www.SpinItPod.com!2021-12-031h 09
2021 Team PresentationsIISER_Bhopal: BLAST : Bifidobacterium Longum induced Apoptosis using Smac and Tr... (2021) - Team Presentation [English]Title: BLAST : Bifidobacterium Longum induced Apoptosis using Smac and Trail (Therapeutic for Solid tumor cancers)
Description: Cancer, the second leading cause of death in the world, registered 19 million cases and about 10 million deaths in 2020 globally. Cancer treatment is both financially and mentally traumatizing for patients as current therapies suffer from a plethora of side effects and are very expensive. Our project presents an innovative approach to treat cancer using apoptosis-inducing peptides SMAC & TRAIL. TRAIL binds to the cancer cells extrinsically, thereby activating caspases, whereas SMAC induces apoptosis intrinsically and also sensitizes TRAIL-resistant cancer cells. Our chassis organism...2021-11-0100 min
PubReadingPubReading [41] - Apoptosis: A Target for Anticancer Therapy - C. M. Pfeffer and A. T. K. SinghApoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway. doi:10.3390/ijms19020448 - 20182021-10-2031 min
La Chaîne du Vivant - Chroniques de Biologie d'Yves Muller5. D’un petit ver transparent aux gènes qui contrôlent le suicide de nos cellulesCette 5ème chronique présente les mécanismes moléculaires impliqués dans une forme de mort cellulaire programmée qu’on appelle l’apoptose. Ces mécanismes sont d’abord explorés chez un petit ver transparent appelé Caenorhabditis elegans puis ils sont abordés chez les Mammifères. Sont ainsi présentés les caspases, les membres de la famille Bcl-2, l’Apaf-1, l’AIF, la voie extrinsèque de l’apoptose mettant en jeu les récepteurs de mort et la voie intrinsèque de l’apoptose mettant en jeu la mitochondrie et régulée par les membres de la famille Bc...2021-09-0434 min
Blood PodcastActivated BCL11B in acute leukemias, SARS-CoV-2 antibody responses in lymphoma patients receiving B-cell therapies, and PD-L1 in neutrophil apoptosis and tissue inflammationIn this week’s episode, we will review a study that shows that BCL11B is an important oncogene in acute leukemias with myeloid and T-lymphoid features, learn more about antibody responses to SARS-CoV-2 vaccination in lymphoma patients receiving B-cell directed therapies, and examine the role of programmed death ligand 1 (or PD-L1) and the PI 3 kinase-AKT survival pathway in delayed neutrophil apoptosis at sites of tissue inflammation.2021-09-0217 min
OncotargetOncotarget: ONC201 Induces Apoptosis in Breast CancerOncotarget published this trending research paper on October 20, 2020, entitled, "TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic" by researchers from Temple University, Philadelphia, PA; Fox Chase Cancer Center, Philadelphia, PA; Brown University, Providence, RI; Brown University and the Lifespan Health System, Providence, RI.
Abstract:
ONC201 was initially identified as an inducer of cell death through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway. The compound is currently being tested in patients with hematological malignancies and solid tumors, including those of the breast. We investigated strategies to convert the response of breast cancers...2021-07-0206 min
La Chaîne du Vivant - Chroniques de Biologie d'Yves Muller5. D’un petit ver transparent aux gènes qui contrôlent le suicide de nos cellulesCette 5ème chronique présente les mécanismes moléculaires impliqués dans une forme de mort cellulaire programmée qu’on appelle l’apoptose. Ces mécanismes sont d’abord explorés chez un petit ver transparent appelé Caenorhabditis elegans puis ils sont abordés chez les Mammifères. Sont ainsi présentés les caspases, les membres de la famille Bcl-2, l’Apaf-1, l’AIF, la voie extrinsèque de l’apoptose mettant en jeu les récepteurs de mort et la voie intrinsèque de l’apoptose mettant en jeu la mitochondrie et régulée par les membres de la famille Bc...2021-06-2934 min
My AP Biology ThoughtsApoptosisMy AP Biology Thoughts Unit 2 Cell Structure and FunctionWelcome to My AP Biology Thoughts podcast, my name is Sid and I am your host for episode #64 called Unit 2 Cell Structure and Function: Why Apoptosis? Segment 1: Introduction to ApoptosisApoptosis is when a cell undergoes a programmed death. This is different from necrosis which is when cells die from injuries. Apoptosis is the most convenient way for an organism to remove cells that need to be removed. Segment 2: More About ApoptosisIn apoptosis a cell commits suicide for...2021-05-1405 min
Thunderdome Metal Reviews: The Church of Heavy MetalAllegaeon, "Apoptosis," (2019)Metalheads!! We head out to Colorado for some technical death metal in the form of Allegaeon's 2019 album Apoptosis. 2021-04-2222 min
Biopedia18- ApoptosisApoptosis is the phenomenon by which cells commit suicide in an orderly and programmed fashion. But why is it important? And what happens if it goes wrong? Today, we're just going to introduce the topic briefly and give some examples of why it is biologically useful.
Sources for this episode:
Alberts, Johnson, Lewis, Raff, Roberts, and Walter (2008), Molecular Biology of the Cell, Fifth Edition. Abingdon: Garland Science, ‘Taylor and Francis Group LLC’.
Thain, M., and Hickman, M. (2014), The Penguin Dictionary of Biology, 11th edition. London: Penguin Publishing Group.
2021-01-3104 min
First Past the PostApoptosisThis episode covers apoptosis!2020-12-2301 min
OncotargetOncotarget - RSK Inhibitor BI - D1870 Inhibits Acute Myeloid Leukemia Cell ProlferationVolume 11, Issue 25 of @Oncotarget reported that to examine the role of RSK in AML, the authors analyzed apoptosis and the cell cycle profile following treatment with BI-D1870, a potent inhibitor of RSK. BI-D1870 treatment increased the G2/M population and induced apoptosis in Acute Myeloid Leukemia cell lines and patient Acute Myeloid Leukemia cells.
Therefore, the authors investigated whether BI-D1870 potentiates the anti-leukemic activity of vincristine by targeting mitotic exit.
Combination treatment of BI-D1870 and vincristine synergistically increased mitotic arrest and apoptosis in acute leukemia cells.
These data show that BI-D1870 induces apoptosis of AML cells alone and in combination...2020-06-2304 min
OncotargetOncotarget - RSK Inhibitor BI - D1870 Inhibits Acute Myeloid Leukemia Cell ProlferationVolume 11, Issue 25 of @Oncotarget reported that to examine the role of RSK in AML, the authors analyzed apoptosis and the cell cycle profile following treatment with BI-D1870, a potent inhibitor of RSK. BI-D1870 treatment increased the G2/M population and induced apoptosis in Acute Myeloid Leukemia cell lines and patient Acute Myeloid Leukemia cells.
Therefore, the authors investigated whether BI-D1870 potentiates the anti-leukemic activity of vincristine by targeting mitotic exit.
Combination treatment of BI-D1870 and vincristine synergistically increased mitotic arrest and apoptosis in acute leukemia cells.
These data show that BI-D1870 induces apoptosis of AML cells alone and in combination...2020-06-2304 min
Apoptosis¿Y los zombies? (Con Max y Yahir)El apocalipsis esta llegando y el mundo esta viendo que pedo.
En el episodio de hoy charlamos sobre la situación actual, casos ridículos, medidas de seguridad y probables futuros.
Siguenos en nuestras redes sociales:
https://www.instagram.com/hi_yahirts/
https://www.instagram.com/max.giron.5/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/ri.raamos/2020-03-2545 min
ApoptosisDreamers (Con Adolfo Alvarez y Jose Feregrino)En esta ocacion nos acompañan dos grandes amigos que han tenido la oportunidad de "brincar el charco" y vivir experiencias que jamas imaginaron. Nos platican lo que es vivir en Alemania, sus dificultades, diferencias y sorpresas.
-------
Redes Fofi y Jose:
https://www.instagram.com/biancoalvareci/
https://www.instagram.com/yeyerock/
-------
Redes Apoptosis:
https://www.instagram.com/_mastergram_/
https://www.instagram.com/ri.raamos/
https://www.instagram.com/muerte.programada/
------2020-03-2056 min
ApoptosisParkour de Mexico a Japon (Con Kiara Guerrero)En el episodio de hoy nos acompaña una invitada talla golden. Atleta profesional, traceur y representante de México en las competencias internacionalesde Parkour.
Nos cuenta un poco de su trayectoria, cómo fue que inicio en el Parkour y que traerá el futuro para ella y la comunidad de Parkour mexicana.
¡El equipo necesita de tu apoyo para este gran viaje! Puedes ayudar haciendo tu donación en el link de abajo, asistiendo a los eventos de Selección Mexicana de Parkour y compartiendo la información.
Link para apoyar al equipo:
https://www.facebook.com/SeleccionMexicanadeParkour/
https://donadora...2020-03-0545 min
ApoptosisVamos a donde vaya la fiesta (Con Rodrigo Alegria)En el episodio de hoy charlamos sobre Drinkery Machine, un muy chido proyecto de nuestro amigo Rodrigo Alegria. Una combi que sirve tragos, ¿Hay mejor combinación que esa?
Redes Drinkery Machine:
https://www.facebook.com/DrinkeryMachine/
https://www.instagram.com/drinkery_machine/
Redes Rod:
https://www.instagram.com/rod_joy/
Redes Apoptosis:
https://www.instagram.com/muerte.programada/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/2020-02-2637 min
ApoptosisExpectativas, videojuegos y autodelicioso (Con Switch On)El dia de hoy charlamos con nuestros amigos de Switch On sobre las expectativas de la vida, el amor y los videojuegos.
Chequen la segunda parte en el canal de Switch On:
Youtube: https://www.youtube.com/channel/UCZ6pK4ywaf5gzd1-uDl5EGQ
Spotify: https://open.spotify.com/show/4mLHEIWmidILcx869Vy7OP?si=-Li0M7GYRGaXhVjzNLPVlw
Itunes: https://podcasts.apple.com/mx/podcast/switchon/id1496878574
Facebook: https://www.facebook.com/SiteStrange/
Twitter: https://twitter.com/StrangeSite
Página: https://sitestrange.wixsite.com/switchon2020-02-1624 min
ApoptosisColeccionables desde el mejor angulo (Con Martin)En esta ocacion charlamos con un buen amigo nuestro, el cual tiene una cuenta de instagram muy flipante. Martin fotografia su coleccion de figuras de Star Wars (en su gran mayoria), logrando tomas increibles como si de un frame de pelicula se tratara.
Redes de Martin:
https://www.instagram.com/joss.toys/
Apoptosis:
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/
https://www.instagram.com/muerte.programada/2020-02-0542 min
ApoptosisPunto sin retorno (Con El Shuy)En este capitulo nos visita un gran muchacho, que un día se despertó y ya era cantautor (broma). Salvador Trejo, alias El Shuy , nos platica un poco de como surgió su propuesta, que lo motivo y como fue todo el proceso de creación de sus dos discos; aparte de unos "facts" sobre él, útiles para esos fans de su trabajo.
Puedes escuchar Shuy aqui:
https://open.spotify.com/artist/2XJprYM16S8rrrFtG4tseD
Redes Shuy:
https://www.instagram.com/shuy.con.s/
Redes Apoptosis:
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/2020-01-2247 min
ApoptosisDar el salto (Con Yahir Hernandez)La primer cosa que hay que hacer para iniciar un gran proyecto es "dar el salto". Hoy nos acompaña Yahir, fotógrafo de la ciudad de Queretaro. él decidió dar el salto hacia las cosas que ama.
#DarElSalto #Apoptosis2020-01-1553 min
ApoptosisPoesía, impresiones y buena vibra (Con Max Girón)Charlamos con nuestro querido y gran amigo Max. Damos un vistazo a su propuesta Poemas con sal y pimienta, hablamos sobre primeras impresiones y salimos motivados para crear cosas nuevas.
Redes Poemas con Sal y Pimienta:
https://www.youtube.com/channel/UCKV-Z7Z12CgD3xsi-vK_BBg
https://www.instagram.com/poemas.salypimienta/
https://www.facebook.com/poemas.salypimienta/
Apoptosis:
https://www.instagram.com/muerte.programada/
https://www.facebook.com/muerte.programada/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/2019-12-0655 min
ApoptosisMiArte (Con Leo Pintado)Hoy nos acompaña el gran Leo Pintado, productor musical, amante de la música y el arte. Charlamos sobre el arte que nos rodea y como impacta en nuestra vida.
Leo Pintado:
https://www.instagram.com/quetransaleo/
Apoptosis:
https://www.instagram.com/muerte.programada/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/
#Arte #Apoptosis2019-11-0843 min
ApoptosisHorror, exorcismos y tattoos (Con Juan Tapia)Nos acompaña Juan Tapia, artista del tattoo y amante del horror. Charlamos sobre peliculas, historias, comics y sucesos locales que nos han pasado o hemos escuchado por ahi.
Redes de Juan:
www.facebook.com/JUANLUISTAPIAJ/
https://www.instagram.com/juanluistapiaj/
Apoptosis:
https://www.facebook.com/muerteprogramada/
https://www.instagram.com/muerte.programada/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/
#Tattoo #Miedo #Apoptosis2019-10-1051 min
ApoptosisVivir de tu arte (Con Andrés Díaz)Comenzamos la segunda temporada con un gran invitado, Andrés Díaz, vocalista de la banda de Thrash Metal Demondeath, músico urbano y gran artista. En este episodio hablamos de música, tendencias y su evolución.
Redes de Andrés:
https://www.instagram.com/andresmondeath/
https://www.instagram.com/demondeathqro/
https://www.facebook.com/AndresDiazMusic96/
https://www.facebook.com/DemondeathHellYeah/
Apoptosis:
https://www.facebook.com/muerteprogramada/
https://www.instagram.com/muerte.programada/
https://www.instagram.com/_mastergram_/
https://www.instagram.com/richitroon/
#Musica #Demondeath #Apoptosis2019-09-2746 minApoptosisRelaciones Toxicas, Relaciones abiertas y actores pornoEn este cierre de temporada charlamos sobre un tema en el que la gran mayoría de nosotros ha estado, ha vivido o al menos escuchado por parte de un amigo, si, hablamos de las relaciones tóxicas. Compartimos contigo algunas experiencias, dudas, consejos y unas sonrisas.2019-08-0958 minApoptosisSueñosPlaticamos sobre los lugares oníricos que hemos visitado y de las malas experiencias que hemos pasado. (?)2019-07-2829 minApoptosisMúsicaEn este capitulo charlamos sobre la musica con la que crecimos y la que nos acompaño en buenos y malos momentos.2019-07-2828 minApoptosisOtakusCharlamos sobre esos seres que se esconden del jabon y aman visitar la friki plaza. Llegaremos al fondo de esto para descubrir quien es el otako de closet :o
Que el cochichi los acompañe.
Siganos en nuestras redes sociales:
https://www.facebook.com/muerteprogra...
https://www.instagram.com/muerte.prog...
https://open.spotify.com/show/2wsDTWh...
#Otaku #Anime #Apoptosis2019-06-2531 minApoptosisConspiracionesRepilianos, Tierra plana y mas encontraras en el episodio 10.
Comparte, dale like y suscribete si te atreves e.e
Que el cochichi los acompañe.
Siganos en nuestras redes sociales:
https://www.facebook.com/muerteprogra...
https://www.instagram.com/muerte.prog...
https://open.spotify.com/show/2wsDTWh...
#Conspiraciones #JuanGa #Apoptosis2019-06-2529 minApoptosisRandom | Episodio 09Destino, peliculas raras, suerte, hablamos de esto en el episodio de hoy.
P.D. Disculpa por las molestias auditivas, teniamos la ventana abierta xd
Que el cochichi los acompañe :3
Siganos en nuestras redes sociales:
https://www.facebook.com/muerteprogra...
https://www.instagram.com/muerte.prog...
https://open.spotify.com/show/2wsDTWh...
#Random #Apoptosis #Podcast2019-06-1631 minApoptosisDaño Ambiental | Episodio 08En esta capsula opinamos sobre el daño ambiental que hemos hecho a lo largo de este tiempo como humanos. No tiren basura, no sean basura.
Que el cochichi los acompañe.
Siganos en nuestras redes sociales:
https://www.facebook.com/muerteprogra...
https://www.instagram.com/muerte.prog...
https://open.spotify.com/show/2wsDTWh...
#BasuraHumana #Contaminación #Apoptosis2019-06-1623 min
From Corners Unknown#94 | Album Review | Allegaeon - ApoptosisApoptosis is breathtaking in its technicality, uplifting in its melodies, and expansive in scope as it effortlessly incorporates tinges of orchestral flair. Continue reading2019-05-131h 22ApoptosisTrabajoEn este capitulo charlamos sobre el trabajo, un poco de sus origenes y el como la rutina puede romper tu espiritu. ¡Aaay weey! No se lo pierdan y dejen su poderoso like. Comenta si amas (odias) tu trabajo xd
Que el cochichi los acompañe.2019-05-1345 min
KYTOS BiologyApoptosis - A very orderly cell deathIn this podcast, we look at the process of apoptosis, or programmed cell death. What is the exact mechanism behind this self destruction, and when would the body employ such a tactic?2019-03-0914 min
Straight from a Scientist Medical Research Education and Discussion PodcastEp. 42: Neuronal Apoptosis- The Cautious and the Willing with Dr. Mohanish Deskmukh and Connor Wander This episode is all about neuronal apoptosis. In Dr. Mohanish Deshmukh's eyes, some cells are willing to undergo apoptosis, while others are very cautious. Understanding these differences could be the key to understanding, treating, or curing diseases that haunt us in modern times. Research in Dr. Deshmukh’s lab at the University of North Carolina, Chapel Hill, focuses on pathways for neuronal apoptosis and the ways that survival and death work in different cells. Apoptosis is programmed cell death. In apoptosis, cells commit "suicide" quietly to minimize inflammation and damage to their neighbors. Apoptos...2019-02-1050 min
Implications of Apoptosis for Symptoms of Parkinson's DiseaseDr. Rollins discusses the critical role that is played by Apoptosis and why it has a critical influence on nervous system health. Apoptosis is the body’s natural process for repairing, regenerating and destroying damaged cells.
He discusses his longtime relationship with Dr. Bill McAnalley who was a recent guest on Parkinsons Recovery Radio and founder of Aroga. .
Dr. Rollins explains how Aroga products and in particular the Core Pathways, Brain and Nerve Plus and Aloe 1 support and nurture neural tissue health.
https://arogalife.com/parkinsons-recovery2018-10-1700 min
Straight from a Scientist Medical Research Education and Discussion PodcastEp. 23: The Role of Apoptosis with Georgia SmithWe had the chance to talk with Georgia Atkin-Smith about different types of cell death, autoimmune disorders, and the optimistic future of the field. Georgia is a final year PhD student in Biochemistry and Immunology at the La Trobe Institute for Molecular Science, Melbourne, Australia. Her PhD project focuses on a type of cell death termed apoptosis and the consequence of this process in disease. Specifically, Georgia's research is aimed to understand the role of apoptotic fragments, known as apoptotic bodies, derived from white blood cells during influenza A virus infection. Connect with Georgia on I...2018-05-0826 min
Fatal Error64. AI ApoptosisThis week, Chris and Soroush review what inheritance in OOP is good for … and the problems it brings with it. Also: an update on the lights in Soroush’s bathroom.
Chris’s Alexa Aircraft Radar skill
Apoptosis
Episode 50: Internet of Things
Wemo Mini Smart Plug
Sylvania HomeKit Bulbs
Philips Tap Switch
Hue Labs Toggle Behavior
Why inheritance never made any sense
Chris: Cocoa’s mutable-subclass pattern is an antipattern
Chris: Multiple Inheritance vs. Traits or Protocol Extensions
Ruby Forwardable module (def_delegator and def_delegators)
Objective-C forwardingTargetForSelector:
Multiple Inheritance in C++ and the Diamond Problem
The Ghost of Swift Bu...2018-04-1338 min
Environmentalism and Personal Detox | Deagle NetworkThe NutriMedical Report Show Hour Two Tuesday Nov 7th 2017 – Consult Solutions FREE eMails from drbilldeagle@hotmail.com, Dr Bill Deagle MD AAEM ACAM A4M, seizure control, topical fungal infection, oral viral infections, dysbiosis, gut SBO Small Bowel Overgrowth, joint inflammation, DNA repair, cancer cell apoptosis, blood viscosity disorders, heart and vascular disease, dementia, depression, chronic fatigue syndrome,Dr Bill Deagle MD AAEM ACAM A4M, www.NutriMedical.com, www.Deagle-Network.com, www.ClayandIRON.com, The NutriMedical Report Show, Consult Solutions FREE eMails from drbilldeagle@hotmail.com, Dr Bill Deagle MD AAEM ACAM A4M, seizure control, topical fungal infection, oral viral infections, dysbiosis, gut SBO Small Bowel Overgrowth, joint inflammation, DNA repair, cancer cell apoptosis, blood viscosity disorders, heart and vascular disease, dementia,...2017-11-0842 min
Geopolitical Analysis of World EventsThe NutriMedical Report Show Hour Two Tuesday Nov 7th 2017 – Consult Solutions FREE eMails from drbilldeagle@hotmail.com, Dr Bill Deagle MD AAEM ACAM A4M, seizure control, topical fungal infection, oral viral infections, dysbiosis, gut SBO Small Bowel Overgrowth, joint inflammation, DNA repair, cancer cell apoptosis, blood viscosity disorders, heart and vascular disease, dementia, depression, chronic fatigue syndrome,Dr Bill Deagle MD AAEM ACAM A4M, www.NutriMedical.com, www.Deagle-Network.com, www.ClayandIRON.com, The NutriMedical Report Show, Consult Solutions FREE eMails from drbilldeagle@hotmail.com, Dr Bill Deagle MD AAEM ACAM A4M, seizure control, topical fungal infection, oral viral infections, dysbiosis, gut SBO Small Bowel Overgrowth, joint inflammation, DNA repair, cancer cell apoptosis, blood viscosity disorders, heart and vascular disease, dementia,...2017-11-0842 min
Nick DurantApoptosisApoptosis by Nick Durant2016-04-0806 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 17/19Der konträre Einfluss von p53 auf die extrinsische und intrinsische Apoptoseinduktion in TumorzellenIn the past view decades the therapy of malignant diseases has improved significantly. However
especially metastatic diseases and relapses still require the development of new therapeutic
modalities. Most chemotherapeutic agents induce apoptosis. A better understanding of apoptosis
signaling is needed in order to combine cytostatic drugs in a more efficient way and to develop new targeted therapies. Conventional cytotoxic drugs and new therapies target p53, a key
regulator of apoptosis. p53 is one of the most intensively studied target proteins but the
heterogeneity and diversity of the function of p53 remains unclear.
We investigated the importance of p53 in the...2014-05-2200 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 05/06Targeting the actin cytoskeleton with natural compoundsTargeting the cytoskeleton (CSK) of cancer cells offers a valuable strategy in cancer therapy. Whereas drugs which address microtubule CSK such as vinca alkaloids or taxanes are well established in the clinic, compounds binding to the actin CSK are still far away from their therapeutical application. One reason might be the lacking knowledge on their mode of cytotoxicity and moreover their tumor specific mechanism of action.
We used the myxobacterial compound Chondramide as a tool to first elucidate the mechanisms of cytotoxicity by actin targeting in different breast cancer cells, namely MCF7 and MDA-MB-231. Chondramide inhibits actin filament assembly and...2014-04-1000 min
Universo paralelo161-Obsolescencia celular programada: Apoptosis -17.02.14-Universo ParaleloObsolescencia celular programada: Apoptosis -17.02.14-Entrevista Juan Ignacio Barrasa López, Doctor en Bioquímica y Biología Molecular por la Universidad Complutense de Madrid.2014-02-2000 min
Medizin - Open Access LMU - Teil 21/22Idebenone Prevents Human Optic Nerve Head Astrocytes From Oxidative Stress, Apoptosis, and Senescence by Stabilizing BAX/Bcl-2 RatioPurpose: Oxidative stress plays an important role in the pathogenesis of several neurodegenerative diseases including glaucoma. Astrocytes are supposed to play a role in glaucoma pathogenesis. This study investigates the antiapoptotic and cytoprotective effects of idebenone on optic nerve head astrocytes (ONHA) under oxidative stress.Methods: ONHA were treated with 1 to 150 mu M idebenone. Cell viability (MTT assay and live-dead assay), induction of intracellular reactive oxygen species, senescence-associated -galactosidase activity were investigated. In addition, apoptosis (detection of histone-associated DNA fragmentation), and expression of BAX and Bcl-2, and their mRNA were determined after 48 hours and after hydrogen peroxide (H2O2) treatment...2013-06-0100 minMedizin - Open Access LMU - Teil 21/22Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signalingBackground: The p53 protein is the best studied target in human cancer. For decades, p53 has been believed to act mainly as a tumor suppressor and by transcriptional regulation. Only recently, the complex and diverse function of p53 has attracted more attention. Using several molecular approaches, we studied the impact of different p53 variants on extrinsic and intrinsic apoptosis signaling. Results: We reproduced the previously published results within intrinsic apoptosis induction: while wild-type p53 promoted cell death, different p53 mutations reduced apoptosis sensitivity. The prediction of the impact of the p53 status on the extrinsic cell death induction was much...2013-01-0100 minMedizin - Open Access LMU - Teil 21/224-Phenylbutyric Acid Reduces Endoplasmic Reticulum Stress, Trypsin Activation, and Acinar Cell Apoptosis While Increasing Secretion in Rat Pancreatic AciniObjectives: Endoplasmic reticulum (ER) stress leads to misfolded proteins inside the ER and initiates unfolded protein response (UPR). Unfolded protein response components are involved in pancreatic function and activated during pancreatitis. However, the exact role of ER stress in the exocrine pancreas is unclear. The present study examined the effects of 4-phenylbutyric acid (4-PBA), an ER chaperone, on acini and UPR components. Methods: Rat acini were stimulated with cholecystokinin (10 pmol/L to 10 nmol/L) with or without preincubation of 4-PBA. The UPR components were analyzed, including chaperone-binding protein, protein kinaselike ER kinase, X-box-binding protein 1, c-Jun NH2-terminal kinase, CCAAT/enhancer-binding...2013-01-0100 minMedizin - Open Access LMU - Teil 20/22Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295RAdrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathway seems to play a major role in ACC aggressiveness, and might, thus, represent a promising therapeutic target.
Similar to patient tumor specimen the H295 cell line derived from an ACC harbors a natural activating β-catenin mutation. We herein assess the in vitro and in vivo effect of β-catenin inactivation using a doxycyclin (dox) inducible shRNA plasmid in H295R adre...2013-01-0100 min
Dog Cancer AnswersApoptosis and How Dietary Apoptogens HelpTopics Covered:
What is Apoptosis
Apoptosis: One of the hallmarks of cancer
Pharmaceutical and Nutraceutical methods of causing apoptosis
Do chemotherapy protocols deal with Apoptosis or not?
The difference between apoptosis cell death and chemotherapy cell death
Other Links:If you would like to ask a dog cancer related question for one of our expert veterinarians to answer on a future Q&A episode, call our Listener Line at 808-868-3200.Dog Cancer News is a free weekly newsletter that contains useful information designed to help your dog with cancer...2012-04-0410 minMedizin - Open Access LMU - Teil 19/22Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts.The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to caspase-8, blocks downstream signaling and thus contributes to viral fitness in macrophages and in vivo. Here we show a direct link between the inability of mutants lacking the M36 gene (ΔM36) to inhibit apoptosis, poor viral growth in macrophage cell cultures and viral in vivo fitness and virulence. ΔM36 grew poorly in RAG1 knockout mice and in RAG/IL-2-receptor common gamma ch...2012-01-0100 minMedizin - Open Access LMU - Teil 19/22Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells.C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C. albicans interactions is the fungal cell wall, we aimed to identify features of the cell wall inducing epithelial responses and be associated with fungal pathogenesis. We demonstrate here the importance of cell wall protein glycosylation in epithelial immune activation with a predominant role for the highly branched N-glycosylation residues. Moreover, these glycan moieties induce growth arrest and apoptosis of epithelial cells. Using an in vitro model of oral candidosis we demonstrate, that...2012-01-0100 minMedizin - Open Access LMU - Teil 18/22Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosisKaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection. Previous studies reported that KSHV is able to inhibit apoptosis during latent infection; we thus tested the involvement of viral miRNAs in this process. We found that both HEK293 epithelial cells and DG75 cells stably expressing KSHV miRNAs were protected from apoptosis. Potential cellular targets that were significantly down-regulated upon KSHV miRNAs expression were identified by microarray profiling. Among them, we validated by luciferase reporter assays, quantitative PCR and western blotting caspase 3 (Casp3), a critical factor for the...2011-12-0100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19Downregulation of endogenous TRAIL and its effect on the human cancer cell line KELLYTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to exert an unexpected pro-survival, pro-proliferative and pro-invasive effect on a subset of human cancer cell lines. Recent clinical studies report that increased expression of endogenous TRAIL is associated with decreased disease-specific survival in renal cell carcinoma and cholangiocarcinoma which are resistant to TRAIL induced apoptosis. The present work investigated the role of endogenous TRAIL as an intrinsic growth factor in apoptosis-resistant human cancer cells.
Several cell lines derived from solid human tumors were studied, among them the neuroblastoma cell line KELLY, a cancer cell line resistant to TRAIL-induced apoptosis. First...2011-11-2400 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 13/19Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cellsMutations in the gene coding for the ATP binding cassette protein A3 (ABCA3) are
known as the most frequent genetic cause of fatal neonatal respiratory distress syndrome
and chronic interstitial lung disease (ILD) of children. ABCA3 transporter is localized to the
limiting membrane of lamellar bodies, organelles for assembly and storage of pulmonary
surfactant in alveolar epithelial type II cells. It transports surfactant phospholipids into
lamellar bodies and is essential for their biogenesis. ABCA3 mutations can result in either
functional defects of the correctly localized ABCA3 or trafficking/folding defects where
mutated ABCA3 remains in the endoplasmic reticulum (ER).
This...2011-11-2400 minMedizin - Open Access LMU - Teil 18/22Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cellsBackground: ABCA3 transporter (ATP-binding cassette transporter of the A subfamily) is localized to the limiting membrane of lamellar bodies, organelles for assembly and storage of pulmonary surfactant in alveolar epithelial type II cells (AECII). It transports surfactant phospholipids into lamellar bodies and absence of ABCA3 function disrupts lamellar body biogenesis. Mutations of the ABCA3 gene lead to fatal neonatal surfactant deficiency and chronic interstitial lung disease (ILD) of children. ABCA3 mutations can result in either functional defects of the correctly localized ABCA3 or trafficking/folding defects where mutated ABCA3 remains in the endoplasmic reticulum (ER). Methods: Human alveolar epithelial A549...2011-01-0100 minMedizin - Open Access LMU - Teil 18/22Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progressionBackground: As cell-free circulating DNA exists predominantly as mono-and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of patients with benign and malignant breast diseases. Methods: The concentrations of cell-free DNA and nucleosomes as well as the protease and caspase activities were measured in serum of patients with benign breast disease (n = 20), primary breast cancer (M0, n = 31), metastatic breast cancer (M1, n = 32), and healthy individuals (n = 28) by PicoGreen, Cell Death Detection ELISA, Protease Fluorescent Detection Kit and Caspase-Glo (R) 3/7 Assay, respectively. Results: Patients with benign and malignant...2011-01-0100 minMedizin - Open Access LMU - Teil 17/22Minocycline is cytoprotective in human corneal endothelial cells and induces anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and X-linked inhibitor of apoptosis (XIAP)Introduction Loss of corneal endothelial cells (CECs) is one major factor limiting transplant clarity and survival after keratoplasty. Amongst other factors, apoptosis due to cellular stress is responsible for these problems. This study investigates the possible anti-apoptotic and cytoprotective effects of minocycline on a human corneal endothelial cell line (HCEC-SV40) cultured under oxidative stress and with transforming growth factor beta (TGF-beta). Methods CECs were treated with 1-150 mM minocycline. Cell viability and the median inhibitory concentration (IC(50)) were evaluated after 48 h and after H(2)O(2) treatment (tetrazolium dye reduction assay and liveedead assay). Expression of B-cell CLL/lymphoma 2 (Bcl-2) and...2010-01-0100 minMedizin - Open Access LMU - Teil 17/22Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cellsIntroduction: The HIV protease inhibitor nelfinavir is currently under investigation as a new anti-cancer drug. Several studies have shown that nelfinavir induces cell cycle arrest, endoplasmic reticulum stress, autophagy, and apoptosis in cancer cells. In the present article, the effect of nelfinavir on human breast cancer cells is examined and potential combination treatments are investigated. Methods: The effects of nelfinavir and tamoxifen on the human breast cancer cell lines MCF7, T47 D, MDA-MB-453, and MDA-MB-435 were tested by analysing their influence on cell viability (via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay), apoptosis (annexin binding, poly(ADP-ribose) polymerase cleavage), autophagy...2010-01-0100 minMedizin - Open Access LMU - Teil 16/22Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis.During acute bacterial infections such as meningitis, neutrophils enter the tissue where they combat the infection before they undergo apoptosis and are taken up by macrophages. Neutrophils show pro-inflammatory activity and may contribute to tissue damage. In pneumococcal meningitis, neuronal damage despite adequate chemotherapy is a frequent clinical finding. This damage may be due to excessive neutrophil activity. We here show that transgenic expression of Bcl-2 in haematopoietic cells blocks the resolution of inflammation following antibiotic therapy in a mouse model of pneumococcal meningitis. The persistence of neutrophil brain infiltrates was accompanied by high levels of IL-1beta and G-CSF...2009-05-0100 minMedizin - Open Access LMU - Teil 16/22Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1 beta-induced NF-kappa B-mediated inflammation and apoptosisIntroduction Currently available treatments for osteoarthritis (OA) are restricted to nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only temporarily effective. Thus novel, safe and more efficacious anti-inflammatory agents are needed for OA. Naturally occurring polyphenolic compounds, such as curcumin and resveratrol, are potent agents for modulating inflammation. Both compounds mediate their effects by targeting the NF-kappa B signalling pathway. Methods We have recently demonstrated that in chondrocytes resveratrol modulates the NF-kappa B pathway by inhibiting the proteasome, while curcumin modulates the activation of NF-kappa B by inhibiting upstream kinases (Akt). However, the combinational effects of these compounds...2009-01-0100 minMedizin - Open Access LMU - Teil 15/22JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.Background: cJun terminal kinase (JNK) is constitutively
activated in most hepatocellular carcinomas (HCCs), yet
its exact role in carcinogenesis remains controversial.
While tumour necrosis factor (TNF)-related apoptosisinducing
ligand (TRAIL) is known as a major mediator of
acquired immune tumour surveillance, and is currently
being tested in clinical trials as a novel cancer therapy,
the resistance of many tumours to TRAIL and concerns
about its toxicity in vivo represent obstacles to its clinical
application. In this study we investigated whether JNK
activity in HCC could contribute to the resistance to
apoptosis in these tumours.
Methods: The effect of JNK/Jun...2009-01-0100 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06Coordination of late stages of cytokinesis by the inhibitor of apoptosis protein BRUCECytokinesis involves the formation of a cleavage furrow, followed by abscission, the cutting of the midbody channel, the final bridge between dividing cells. Recently, the midbody ring became known as central for abscission, but its regulation remains enigmatic. This study identifies BRUCE, a 528 kDa multi-functional protein, which processes ubiquitin-conjugating activity, as a major regulator of abscission. During cytokinesis, BRUCE moves from the vesicular system to the midbody ring and serves as a platform for the membrane delivery machinery and mitotic regulators. Depletion of BRUCE in cell cultures causes defective abscission and cytokinesis-associated apoptosis, accompanied by a block of vesicular targeting...2008-07-1600 min![[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)](https://nanohub.org/site/resources/2007/08/03046/itunes_audio.png)
[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)BME 695N Lecture 17: Assessing nanotoxicity at the single cell levelOutline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned "cell injury" Apoptosis is planned "programmed cell death" Why it is important to distinguish between necrosis and apoptosisSingle cell assays for necrosis and apoptosis Dye exclusion assays for necrosis TUNEL assays for late apoptosis Annexin V assays for early apoptosis COMET assays for DNA damage and repair Light scatter assaysNanotoxicity in vivo – some additional challenges Single cell...2007-11-0600 min[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)BME 695N Lecture 17: Assessing nanotoxicity at the single cell levelOutline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned "cell injury" Apoptosis is planned "programmed cell death" Why it is important to distinguish between necrosis and apoptosisSingle cell assays for necrosis and apoptosis Dye exclusion assays for necrosis TUNEL assays for late apoptosis Annexin V assays for early apoptosis COMET assays for DNA damage and repair Light scatter assaysNanotoxicity in vivo – some additional challenges Single cell...2007-11-0600 min[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)BME 695N Lecture 17: Assessing nanotoxicity at the single cell levelOutline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned "cell injury" Apoptosis is planned "programmed cell death" Why it is important to distinguish between necrosis and apoptosisSingle cell assays for necrosis and apoptosis Dye exclusion assays for necrosis TUNEL assays for late apoptosis Annexin V assays for early apoptosis COMET assays for DNA damage and repair Light scatter assaysNanotoxicity in vivo – some additional challenges Single cell...2007-11-0600 min[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)BME 695N Lecture 17: Assessing nanotoxicity at the single cell levelOutline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned "cell injury" Apoptosis is planned "programmed cell death" Why it is important to distinguish between necrosis and apoptosisSingle cell assays for necrosis and apoptosis Dye exclusion assays for necrosis TUNEL assays for late apoptosis Annexin V assays for early apoptosis COMET assays for DNA damage and repair Light scatter assaysNanotoxicity in vivo – some additional challenges Single cell...2007-11-0600 minTierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 02/07Investigations of extracellular matrix proteases, apoptotic and anti-apoptotic factors in the bovine corpus luteumThe study is subdivided into two different parts: the first part deals with the development of a method to gain uterus milk in vivo during the preimplantation periode in cattle for the investigation of regulatory factors. The second part investigates different proteases in bovine follicles 20 hours after GnRH (Gonadotropin releasing hormone) injection (shortly bevor ovulation) for comparable as well as in the corpus luteum (CL) during oestrous cycle and induced luteolysis. In addition apoptotic as well as anti-apoptotic factors were evaluated in the CL during oestrous cycle and induced luteolysis.
For the development of a method for gaining uterus milk...2006-07-2800 minMedizin - Open Access LMU - Teil 14/22The membrane targeted apoptosis modulators erucylphosphocholine and erucylphosphohomocholine increase the radiation response of human glioblastoma cell lines in vitroBackground: Alkylphosphocholines constitute a novel class of antineoplastic synthetic phospholipid derivatives that induce apoptosis of human tumor cell lines by targeting cellular membranes. We could recently show that the first intravenously applicable alkylphosphocholine erucylphosphocholine (ErPC) is a potent inducer of apoptosis in highly resistant human astrocytoma/glioblastoma cell lines in vitro. ErPC was shown to cross the blood brain barrier upon repeated intravenous injections in rats and thus constitutes a promising candidate for glioblastoma therapy. Aim of the present study was to analyze putative beneficial effects of ErPC and its clinically more advanced derivative erucylphosphohomocholine (erucyl-N, N, N-trimethylpropanolaminphosphate, ErPC3, Erufosine...2006-01-0100 minMedizin - Open Access LMU - Teil 13/22Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.Background: Bile acid-induced apoptosis in hepatocytes can be antagonized by NF-κBdependent
survival pathways. Sulfasalazine modulates NF-κB in different cell types. We aimed
to determine the effects of sulfasalazine and its metabolites sulfapyridine and 5-aminosalicylic
acid (5-ASA) on bile acid-induced apoptosis in hepatocytes.
Methods: Apoptosis was determined by caspase assays and immunoblotting, NF-κB activation
by EMSA and reporter gene assays, generation of reactive oxygen species (ROS)
fluorometrically, bile secretion gravimetrically and bile acid uptake radiochemically and by
gaschromatography in HepG2-Ntcp cells and isolated perfused rat livers.
Results: Glycochenodeoxycholic acid (GCDCA, 75μmol/L)-induced apoptosis was reduced by
sulf...2005-01-0100 min