Shows
OncotargetmicroRNAs Emerge as Biomarkers and Diagnostic Tools in Soft Tissue SarcomaBUFFALO, NY - July 18, 2025 – A new #editorial was #published in Volume 16 of Oncotarget on July 16, 2025, titled “microRNAs in soft tissue sarcoma: State of the art and barriers to translation.”
In this article, Elizaveta K. Titerina, Alessandro La Ferlita, and Joal D. Beane from Ohio State University discuss the role of microRNAs in soft tissue sarcomas (STS), a rare and diverse group of cancers that begin in connective tissues, like bone or fat. The authors explain how these small molecules regulate cancer-related processes and highlight their potential as non-invasive biomarkers for diagnosis and monitoring. They also outline the main challenges that need t...2025-07-1803 min
Aging-USNow Accepting Submissions: Special Collection on Cognitive AgingBUFFALO, NY — July 8, 2025 — As populations worldwide continue to age, understanding the mechanisms and manifestations of cognitive aging is increasingly urgent for science, medicine, and society. Age-related cognitive decline ranges from mild memory lapses to the onset of dementia, and is shaped by a complex interplay of molecular, cellular, systemic, and social determinants.
In this special collection, Aging (Aging-US) seeks to bring together cutting-edge research that spans the cellular and molecular underpinnings of cognitive aging with insights into the psychosocial, behavioral, and environmental factors that modulate its course. By integrating basic biology with translational and societal dimensions, this collection aims to fost...2025-07-0803 min
Good Medicine PodcastVocal Biomarkers & Disease Detection | Henry O'ConnellThis week on Good Medicine, we sit down with Henry O’Connell, CEO of Canary Speech, a company using vocal biomarkers to revolutionize mental and neurological health diagnostics.With a career spanning leadership roles at NIH, HP, and MOXTEK, Henry brings decades of insight into how technology can transform healthcare. In this episode, he explains how Canary’s voice analysis tools are giving doctors a clearer picture of patient health, removing global bias from diagnostics, and helping parents better support their kids’ emotional well-being.🔍 We explore:How vocal data can complement traditional medical tools...2025-07-011h 02
ClinPharmPodCTS Call for Papers: BiomarkersBiomarkers have transformed the landscape of clinical and translational sciences and are accelerating the progress towards targeted and precision medicine. Breakthrough technological advancement coupled with novel data analysis methods is driving innovations in biomarker identification and validation and is increasingly making biomarkers crucial for drug development and improving patient outcomes. Listen as Clinical and Translational […]2025-05-1908 min
Aging-USLongevity & Aging Series (S3, E1): Dr. Yu-Xuan LyuIn the Season 3 premiere of the Longevity & Aging Series, Dr. Yu-Xuan Lyu from Southern University of Science and Technology (Shenzhen, China) joins host Dr. Evgeniy Galimov to discuss his co-authored research paper, featured as the cover for Aging (Aging-US) Volume 16, Issue 20, titled “Longevity biotechnology: bridging AI, biomarkers, geroscience, and clinical applications for healthy longevity.”
#aging #author #interview #series #biotechnology #ai #artificialintelligence #longevity #healthspan #lifespan #oa #openscience #peerreview #journal #publication #publishing #meded #agingshort #video
DOI - https://doi.org/10.18632/aging.206135
Corresponding authors - Yu-Xuan Lyu - lvyx@sustech.edu.cn, Alex Zhavoronkov - alex@insilico.com, Morten Scheibye-Knudsen - mscheibye@sund.ku.d...2025-02-2253 min
Mind Body MotherOptimizing Blood Sugar, Cholesterol and Becoming the CEO of My Own HealthOn her 36th birthday and the one year anniversary of the podcast, MBM host Helene Kusman shares her experience managing blood sugar, cholesterol and becoming the CEO of her own health. She gets into how she tested 100+ biomarkers to uncover hidden health issues without having to visit a doctor or go through insurance. Helene addresses questions she has gotten from the audience about wearing a Continuous Glucose Monitor (CGM) and the metabolic health results that led her to do so. She also shares about her Integrative Nutrition training as a component of taking control of her health. If you f...2025-02-2026 min
Sinapsos Podcast | OncologyUrine VOCs and Cancer DetectionE7 | 13 min | Latest | Publication Source
Podcast based on: Hara T, Meng S, Arao Y, Saito Y, Inoue K, Alshammari AH, Hatakeyama H, di Luccio E, Vecchione A, Hirotsu T, et al. Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine. Biomedicines. 2025; 13(1):109. https://doi.org/10.3390/biomedicines13010109
Type: Review | Publication date: Jan 6, 2025
Summary: This review article examines the potential of volatile organic compounds (VOCs) in urine as non-invasive cancer biomarkers. It explores several detection methods, including mass spectrometry analysis of VOC profiles in various cancers, the use of trained organisms (dogs and nematodes) to detect cancer-specific...2025-01-0713 minSinapsos Podcast | OncologyHead and Neck Cancer Re-irradiation OutcomesE2 | 8 min | Latest | Publication Source
Podcast based on: Schleifenbaum, J.K., Morgenthaler, J., Sharma, S.J. et al. Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre analysis. Radiat Oncol 20, 1 (2025). https://doi.org/10.1186/s13014-024-02570-y
Type: Article | Publication date: Jan 2, 2025
Summary: This single-centre retrospective study analysed outcomes for 101 patients with locally recurrent head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy (RT), with or without chemotherapy or immunotherapy, between 2010 and 2018. The study identified several prognostic factors influenci...2025-01-0608 min
BASELINE: AI’s Unstoppable Rise#014 - Ross Parrett - AI, Global Power Shifts & the Tower of BabelJoin us as Ross unpacks global finance, AI, and the Tower of Babel’s modern parallels in this thought-provoking episode—insights only, not investment advice!
START HERE: https://www.youtube.com/playlist?list=PLbdDIi2BAcBvR9x7cOZeod8pQ58p_3xzS
In this riveting episode of BASELINE, Ross joins us to unravel a fascinating mix of topics that span global economics, cutting-edge technology, and humanity’s future. We explore the evolution of industries like Amazon FBA and car manufacturing, the implications of gigafactories, and the opportunities presented by longevity research and biomarkers. From cryptocurrency trust issues to the rise of mBridg...2024-12-091h 01
Aging-USBehind the Study: Longevity Biotechnology - AI, Biomarkers & Geroscience for Healthy AgingDrs. Alex Zhavoronkov, Morten Scheibye-Knudsen, Evelyne Bischof and Dominika Wilczok discuss a research paper they co-authored that was published as the cover of Aging (Aging-US) Volume 16, Issue 20, entitled, “Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.”
DOI - https://doi.org/10.18632/aging.206135
Corresponding Authors - Yu-Xuan Lyu - lvyx@sustech.edu.cn, Alex Zhavoronkov - alex@insilico.com, Morten Scheibye-Knudsen - mscheibye@sund.ku.dk, and Daniela Bakula - bakula@sund.ku.dk
Video interview - https://www.youtube.com/watch?v=2nqvJ8cn5Fg
Video transcript - https://www.aging-us.com/interviews/longevity-biotechnology-ai-biomarkers-geroscience-for-healthy-aging
Sign up for...2024-11-2114 min
Aging-USAging’s Commitment to Advancing Research: Sponsoring the “Future of Aging Research Mixer”Aging (Aging-US) was a proud sponsor of the “Future of Aging Research Mixer 2024” hosted by the Aging Initiative at Harvard University on November 15 in Boston. This event united a vibrant community of students, researchers and technologists, all driven by a shared mission: advancing innovations in aging research and longevity science.
Key Highlights from the Future of Aging Research Mixer 2024
The event kicked off with inspiring opening remarks and a keynote by George Church, professor at Harvard Medical School, founding member of the Wyss Institute, and co-founder of over 50 biotech companies. He was joined by Kat Kajderowicz, an MIT PhD student and...2024-11-2004 min
Aging-USPhenotypic and Epigenetic Clocks for Aging and MortalityBUFFALO, NY- November 20, 2024 – This #review was #published by Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), in Volume 16, Issue 17, titled, “A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans.”
This systematic review by Brandon Warner, Edward Ratner, Anirban Datta and Amaury Lendasse from Verseon International Corporation, University of Houston and Missouri University of Science and Technology, explores how biological clocks measure aging and predict mortality. These clocks are tools scientists use to track the body's aging process by identifying specific changes over time.
This review analyzes 33 biolog...2024-11-2004 min
Aging-USHow AI and Longevity Biotechnology are Revolutionizing Healthcare for Healthier, Longer LivesImagine a future where we not only live longer but stay healthy throughout those extra years. Thanks to recent breakthroughs in biotechnology and artificial intelligence (AI) in healthcare, this vision is closer to becoming a reality.
Advancements in Aging Research
Aging research has made significant progress in recent years by combining disciplines like biology, technology, and medicine to tackle the challenges of extending healthspans and reducing age-related diseases. While people today live longer than ever before, extending our “healthspan”—the years we stay active and illness-free—remains challenging. AI and health biomarkers (biological indicators of our body’s condition) are now key to...2024-11-0604 min
OncotargetPrecision Medicine in SCLC: DLL3, ASC1, TTF-1, and Ki-67 ExpressionBUFFALO, NY - November 6, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on October 11, 2024, entitled “Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC”
This study, led by researchers from the Federal University of Ceará in Brazil and collaborating institutions in Brazil, Argentina and Spain, presents important findings on small cell lung cancer (SCLC), one of the most aggressive forms of lung cancer with limited treatment options. The research reveals how specific biomarkers in SCLC tumors could open new opportunities for more personalized and targeted therapies for these patients.
SCLC accounts for abo...2024-11-0603 min
Aging-USLongevity Biotechnology: AI, Biomarkers, Geroscience & Applications for Healthy AgingBUFFALO, NY- October 31, 2024 – A new #research paper was #published as the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 20, entitled, “Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.”
This paper summarizes recent advances in healthspan biotechnology discussed at the 2023 Aging Research and Drug Discovery Meeting (ARDD), where leading experts reviewed breakthroughs in artificial intelligence (AI), biomarkers, aging clocks, geroscience, and clinical trials that support healthier, longer lives. The authors present a comprehensive view of how these technologies are shaping research and industry approaches to aging, focusi...2024-10-3104 min
Aging-USCardiovascular Risk Biomarkers in InflammagingBUFFALO, NY- October 29, 2024 – A new #editorial was #published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 19 on October 14, 2024, entitled “Integrating cardiovascular risk biomarkers in the context of inflammaging.”
Cardiovascular diseases (CVD) remain the leading cause of death worldwide, accounting for nearly one-third of all global mortalities. Risk assessment for CVD has traditionally focused on well-known factors linked to atherosclerosis, including demographics, lifestyle choices like smoking and physical activity, and conditions such as diabetes, hypertension, and obesity. Biomarkers, such as non-HDL cholesterol, have also played a key role in identifying those at risk.
Howev...2024-10-2903 min
Aging-USImpact of Exercise on Aging: Highlighting Muscle BiomarkersBUFFALO, NY- August 21, 2024 – A new #editorial was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15 on August 8, 2024, entitled, “The benefits of exercise on aging: focus on muscle biomarkers.”
The focus on maintaining health and vitality (e.g., good healthspan) in later life has become increasingly important as the world’s population ages. Over the past few decades, groundbreaking research in the field of aging has deepened our understanding of the molecular basis of this process. In the last decade, advances in aging research have identified biomarkers such as DNA methylat...2024-08-2103 minAging-USHow Physical Fitness and Lifestyle Impact Biological AgingBUFFALO, NY- August 20, 2024 – A new #editorial was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15 on July 19, 2024, entitled, “Physical fitness and lifestyles associated with biological aging”.
Given the growing aging population worldwide, it is crucial to develop interventional strategies that target aging itself, rather than focusing solely on organ- or disease-based medicine. The geroscience hypothesis, which suggests that delaying aging can prevent the onset of diseases, is gaining traction due to advancements in aging biomarkers, driven by improvements in both measurement techniques (e.g., omics) and analytical technologies (e.g., bi...2024-08-2002 min
Aging-USRecalibrating Principles of Epigenetic Aging Clocks in Human HealthBUFFALO, NY- August 14, 2024 – A new #editorial was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 17, 2024, entitled, “Recalibrate concepts of epigenetic aging clocks in human health.”
As detailed in the opening of this editorial, DNA methylation-based epigenetic clocks are used as biomarkers of biological age in human health. Multiple epigenetic clocks have rapidly emerged in the past decade by modeling DNA methylation changes with age in large cohorts, primarily using peripheral blood samples. Despite efforts to understand the functional implications of features used to estimate biological age, the underl...2024-08-1402 min
Biohacker's PodcastOptimize Lab Results with Genetics with Joe CohenIn this episode, Teemu Arina meets Joe Cohen, CEO of SelfDecode, to discuss the complex nature of a purely data-driven approach to biohacking via genetic testing and various biomarkers.Joe recalls his biohacking journey, his trial-and-error approach, years of self-experimentation, following gurus (and then choosing not to do so anymore) and the incredible insights which led to him ultimately founding SelfDecode.SelfDecode is the only company in the world which directly provides their users with a holistic set of accurate health recommendations based on their genes. This allows them to take charge of their own...2024-08-141h 05
StartUp Health NOW PodcastAn Insider’s Perspective on the Near Future of Alzheimer’s Care"Academia is a great area and fosters innovation, but then taking that science and translating it into something that can actually impact human health has a number of challenges. So trying to understand what those barriers are and how we can help bridge them is something that we have been able to do at ADDF and in collaboration with StartUp Health."
In this episode of StartUp Health NOW, we chat with Laura Nisenbaum, PhD, Executive Director of Drug Development at the Alzheimer's Drug Discovery Foundation (ADDF). Organizations like ADDF are working to translate scientific research into real patient impact, particularly...2024-08-0900 min
Ever Forward Radio with Chase Chewning$100 Now or $900,000 Later - The 17 Critical Blood Biomarkers to Know that Can Prevent Heart Disease, Reverse Diabetes and Every Other Chronic Illness and Disease with Michael DubrovskyThis episode is brought to you by SiPhox Health. What if you could prevent chronic diseases before they even manifest? Join us this week as we speak with Michael Dubrovsky, co-founder of SiPhox Health, who reveals the transformative potential of diagnostic testing. We delve deep into the science of biomarkers like hormones, cholesterol, and blood sugar levels, highlighting how understanding these can help you take proactive steps towards a healthier life. Michael shares his expert insights on how early detection through blood work can guide you in managing and even reversing conditions such as cardiovascular disease. 2024-08-0552 minOncotargetBTK Inhibitor-related Cardiotoxicity: Quest for Predictive Biomarkers, Improved Risk StratificationBUFFALO, NY- June 4, 2024 – A new research perspective was published in Oncotarget's Volume 15 on June 3, 2024, entitled, “Bruton’s tyrosine kinase inhibitor-related cardiotoxicity: The quest for predictive biomarkers and improved risk stratification.”
In this new perspective, researchers Jai N. Patel, Jai Singh, and Nilanjan Ghosh from Atrium Health discuss Ibrutinib — the first Bruton's tyrosine kinase (BTK) inhibitor approved for the treatment of patients with chronic lymphocytic leukemia (CLL).
“While producing durable responses and prolonging survival, roughly 20–25% of patients experience dose limiting side effects, mostly consisting of cardiovascular toxicities like severe hypertension and atrial fibrillation.”
While clinical predictors of BTK inhibitor-related cardiotoxicity have been proposed an...2024-06-0402 min
Aging-USInflammatory and Metabolic Biomarkers and Accelerated Aging in Cardiac Catheterization PatientsBUFFALO, NY- May 7, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients.”
Research into aging has grown substantially with the creation of molecular biomarkers of biological age that can be used to determine age acceleration. Concurrently, nuclear magnetic resonance (NMR) assessment of biomarkers of inflammation and metabolism provides researchers with new ways to examine intermediate risk factors for chronic disease.
In this new study, researchers Henry Raab, Elizabeth R. Hauser, Lydia...2024-05-0703 min
Pharmacy Podcast NetworkPharmacogenomics Databases: What’s Available and How to Navigate Them | Precision Health and PGxEpisode Summary:
In recognition of National DNA Day, April 25, 2024, Dr. Mary Weissman, Miss Courtney Harmon, and Dr. Becky Winslow discuss clinical pharmacogenomics resources, what pharmacogenomics information they provide, and how to navigate and utilize the pharmacogenomics information to answer a prescriber’s clinical question about pharmacogenomics' relationship to an adverse drug event. Listeners interested in learning a step-wise approach to using the Food and Drug Administration's (FDA's) Table of Pharmacogenetics Associations and the FDA Table of Pharmacogenomic Biomarkers in Drug Labeling, the Clinical Pharmacogenetics Implementation Consortium's (CPIC's) database, and the Pharmacogenomics Knowledgebase (PharmGKB) to demystify pharmacogenomics' role in adv...2024-04-2524 min
Precision Health and PGx PodcastPharmacogenomics Databases: What’s Available and How to Navigate Them | Precision Health and PGXEpisode Summary:
In recognition of National DNA Day, April 25, 2024, Dr. Mary Weissman, Miss Courtney Harmon, and Dr. Becky Winslow discuss clinical pharmacogenomics resources, what pharmacogenomics information they provide, and how to navigate and utilize the pharmacogenomics information to answer a prescriber’s clinical question about pharmacogenomics' relationship to an adverse drug event. Listeners interested in learning a step-wise approach to using the Food and Drug Administration's (FDA's) Table of Pharmacogenetics Associations and the FDA Table of Pharmacogenomic Biomarkers in Drug Labeling, the Clinical Pharmacogenetics Implementation Consortium's (CPIC's) database, and the Pharmacogenomics Knowledgebase (PharmGKB) to demystify pharmacogenomics' role in adv...2024-04-2524 min
OncotargetIdentifying Biomarkers for Predicting Paclitaxel ResponseCancer therapy has come a long way from its one-size-fits-all beginning to the awakening era of personalized medicine. This change has been largely driven by the discovery of biomarkers. Biomarkers can help refine patient selection for specific therapies. A blend of causal and correlative approaches is needed to elucidate the full potential of biomarkers in cancer research. This fusion of methodologies allows for a comprehensive exploration of biomarker efficacy, leading to more accurate predictions of drug response.
In a new paper, researchers Alberto Moscona-Nissan, Karl J. Habashy, Victor A. Arrieta, Adam M. Sonabend, and Crismita Dmello from the Universidad Panamericana...2024-03-2805 min
wise athletesOptimal Human & Bone Health | Dr Doug Lucas DOFullscript for WiseAthletes
This is part 2 of my bone health exploration, and this time the question is what should I do if I have osteoperosis? Is it game over? No. Absolutely not. But you will need to work hard to recover the bone health you lost.
Doug Lucas, DO, Board Certified Orthopedic Surgeon and Anti-Aging Specialist, will give you insight into the lifestyle, nutrition, testing, and medical solutions for Osteoporosis management and yes, possibly, even reversal. Avoiding pharmaceuticals if at all possible.
Dr Doug Lucas is a double board certified physician specializing in...2024-03-241h 18wise athletes podcastOptimal Human & Bone Health | Dr Doug Lucas DOFullscript for WiseAthletes
This is part 2 of my bone health exploration, and this time the question is what should I do if I have osteoperosis? Is it game over? No. Absolutely not. But you will need to work hard to recover the bone health you lost.
Doug Lucas, DO, Board Certified Orthopedic Surgeon and Anti-Aging Specialist, will give you insight into the lifestyle, nutrition, testing, and medical solutions for Osteoporosis management and yes, possibly, even reversal. Avoiding pharmaceuticals if at all possible.
Dr Doug Lucas is a double board certified physician specializing in...2024-03-241h 18
wise athletes podcast#129 | Optimal Human & Bone Health | Dr Doug Lucas DOFullscript for WiseAthletes
This is part 2 of my bone health exploration, and this time the question is what should I do if I have osteoperosis? Is it game over? No. Absolutely not. But you will need to work hard to recover the bone health you lost.
Doug Lucas, DO, Board Certified Orthopedic Surgeon and Anti-Aging Specialist, will give you insight into the lifestyle, nutrition, testing, and medical solutions for Osteoporosis management and yes, possibly, even reversal. Avoiding pharmaceuticals if at all possible.
Dr Doug Lucas is a double board certified physician specializing in...2024-03-241h 18
Aging-USAssociation of Prenatal Vitamins and Metals With Epigenetic Aging at Birth and in ChildhoodBUFFALO, NY- March 12, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort.”
Epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration (EAA) in childhood may be biomarkers of the intrauterine environment. In this new study, researchers Anne K. Bozack, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Robert O. Wright, Diane R. Gold, Emily Oken, Marie-France Hivert, and Andres Cardenas from Stanford University School...2024-03-1203 min
OncotargetCombining Causal and Correlative Approaches to Discover Response Biomarkers to PaclitaxelBUFFALO, NY- February 21, 2024 – A new research #perspective was #published in Oncotarget's Volume 15 on February 8, 2024, entitled, “Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.”
As discussed in this new paper, researchers Alberto Moscona-Nissan, Karl J. Habashy, Victor A. Arrieta, Adam M. Sonabend, and Crismita Dmello from Universidad Panamericana School of Medicine, Northwestern University and Universidad Nacional Autónoma de México recently discovered a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
“To further...2024-02-2102 min
The Mindplex PodcastEpisode 20: Michael Lustgarden-Leveraging BiomarkersSend us a textMichael Lustgarden explains how he uses aging biomarkers from a basic CBC panel to track and, with course correction (supplements or diet changes), gradually slow down one's rate of aging. Michael's basic premise is that aging and disease are biochemical processes that happen over many decades. So if we can track just even the standard biomarkers of organ and systemic function, that's the things you usually get at a yearly physical, even just starting there, if you can track and then knowing how these biomarkers change during aging, and how they...2024-02-051h 23
Aging-USExploring the Relationship Between Klotho and Telomere Biology in High-Stress CaregiversA new research paper was published by Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) in Volume 15, Issue 15, entitled, “Associations between klotho and telomere biology in high stress caregivers.”
Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulator that acts as a circulating hormone with critical involvement in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammatory functioning.
In this new study, researchers Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena...2023-08-1703 min
Aging-USPrecious1GPT: Multimodal Transfer Learning for Aging Clock Development and Target DiscoveryA new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 11, entitled, “Precious1GPT: multimodal transformer-based transfer learning for aging clock development and feature importance analysis for aging and age-related disease target discovery.”
Aging is a complex and multifactorial process that increases the risk of various age-related diseases and there are many aging clocks that can accurately predict chronological age, mortality, and health status. These clocks are disconnected and are rarely fit for therapeutic target discovery.
In this study, researchers Anatoly Urban, Denis Sidorenko, Diana Zagirova, Ekaterina Kozl...2023-06-2003 min
Aging-USDNAmFitAge: Biological Age Indicator Incorporating Physical FitnessA new research paper was published in Aging (Aging-US) Volume 15, Issue 10, entitled, “DNAmFitAge: biological age indicator incorporating physical fitness.”
Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction.
In this new study, researchers develop blood-based DNAm biomarkers for fitness parameters including gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest correlation with fitness para...2023-06-0703 min
OncotargetRole of Biomarkers in Management of Lumps in the BreastDr. Georg F. Weber, from the University of Cincinnati Academic Health Center, describes a research perspective he authored that was published by Oncotarget in Volume 14, entitled, “Crossroads: the role of biomarkers in the management of lumps in the breast.”
DOI - https://doi.org/10.18632/oncotarget.28402
Correspondence to - Georg F. Weber - georg.weber@uc.edu
Abstract
Premalignant lesions in the breast pose a difficult decision-making problem, whether to treat proactively and accept the side effects or to engage in watchful waiting and possibly encounter a later diagnosis of invasive cancer. A biomarker or set of biomarkers to inform on the...2023-05-0903 min
OncotargetLY6 Gene Family: Potential Tumor Antigens and Prognostic Biomarkers in Endometrial CancerA new research paper was published in Oncotarget's Volume 14 on May 4, 2023, entitled, “Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma.”
The human Lymphocyte antigen-6 (LY6) gene family has recently gained interest for its possible role in tumor progression. In this new study, researchers Luke A. Rathbun, Anthony M. Magliocco and Anil K. Bamezai from Villanova University carried out in silico analyses of all known LY6 gene expression and amplification in different cancers using TNMplot and cBioportal. In addition, the team analyzed patient survival by Kaplan-Meier plotter after mining the TCGA database.
“We report...2023-05-0802 minOncotargetCrossroads: The Role of Biomarkers in the Management of Lumps in the BreastA new research perspective was published in Oncotarget's Volume 14 on April 24, 2023, entitled, “Crossroads: the role of biomarkers in the management of lumps in the breast.”
Here, Dr. Georg F. Weber from the University of Cincinnati Academic Health Center discusses a long-standing issue in women’s health: lumps in the breast. Women over the age of 40 years often have lumps in their breasts that are not cancerous at the time of biopsy (comprising atypias, hyperplasias, papillomas, radial scars, lobular carcinoma in situ, ductal carcinoma in situ (DCIS)). These premalignant lesions in the breast pose a difficult decision-making problem, whether to treat proact...2023-05-0202 min
Biohacker's PodcastNutritional Ketosis with Dr. Jeff VolekWith two decades studying nutritional ketosis, Dr. Jeff Volek offers some amazing insights into the many health benefits of a ketogenic diet for human health and longevity.Dr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last two decades, he has performed cutting-edge research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scientific manuscripts and five books, and he has provided more than 200 lectures at scientific and...2023-03-3144 min
Aging-USAssociations of APOE-TOMM40-APOC1 Variants With Alzheimer’s Disease BiomarkersA new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 24, entitled, “Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers.”
Capturing the genetic architecture of Alzheimer’s disease (AD) is challenging because of the complex interplay of genetic and non-genetic factors in its etiology. It has been suggested that AD biomarkers may improve the characterization of AD pathology and its genetic architecture. Most studies have focused on connections of individual genetic variants with AD biomarkers...2023-01-0505 min
Aging-USDNA Methylation GrimAge Version 2A new research paper was published in Aging (listed as “Aging (Albany NY)” by MEDLINE/PubMed and “Aging-US” by Web of Science) Volume 14, Issue 23, entitled, “DNA methylation GrimAge version 2.”
Researchers Ake T. Lu, Alexandra M. Binder, Joshua Zhang, Qi Yan, Alex P. Reiner, Simon R. Cox, Janie Corley, Sarah E. Harris, Pei-Lun Kuo, Ann Z. Moore, Stefania Bandinelli, James D. Stewart, Cuicui Wang, Elissa J. Hamlat, Elissa S. Epel, Joel D. Schwartz, Eric A. Whitsel, Adolfo Correa, Luigi Ferrucci, Riccardo E. Marioni, and Steve Horvath from the University of California Los Angeles, Altos Labs, University of Hawaii at Manoa, Fred Hutchinson C...2022-12-2103 min
Oncotargetp-STAT3 & c-Myc Correlate With P2-HNF4α Expression in Nonalcoholic Fatty Liver DiseaseA new research paper was published in Oncotarget's Volume 13 on December 6, 2022, entitled, “Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD).”
Nonalcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome and is rapidly becoming one of the major causes of hepatic cirrhosis and hepatocellular carcinoma (HCC), although some cases of HCC have developed in non-cirrhotic livers [1–8]. Although the percentage of patients with NAFLD who ultimately progress to fibrosis and later to HCC is relatively small, the number is significant because of the sheer number of patients who have NAFLD. Because there are no...2022-12-0604 min
OncotargetEssential Amino Acids as Diagnostic Biomarkers of Hepatocellular CarcinomaA new research paper was published in Oncotarget's Volume 13 on November 22, 2022, entitled, “Essential amino acids as diagnostic biomarkers of hepatocellular carcinoma based on metabolic analysis.”
Metabolomics, defined as the comprehensive identification of all small metabolites in a biological sample, has the power to shed light on phenotypic changes associated with various diseases, including cancer.
In the current study, researchers Yuji Morine, Tohru Utsunomiya, Hisami Yamanaka-Okumura, Yu Saito, Shinichiro Yamada, Tetsuya Ikemoto, Satoru Imura, Shohei Kinoshita, Akiyoshi Hirayama, Yasuhito Tanaka, and Mitsuo Shimada from Tokushima University Graduate School, Keio University and Kumamoto University used metabolomics to discover potential biomarkers of hepatocellular carc...2022-12-0204 min
OncotargetBiomarkers May Predict Neoadjuvant Chemosensitivity in Bladder CancerListen to a blog summary of a research paper published in Volume 13, entitled, "Predictive molecular biomarkers for determining neoadjuvant chemosensitivity in muscle invasive bladder cancer."
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Neoadjuvant chemotherapy (NAC) is a type of cancer treatment involving the administration of chemotherapy drugs before surgery. The goal of NAC is to shrink the tumor(s) in order to make it/them easier to remove during surgery and to decrease the chance of cancer recurrence after treatment. NAC is typically well tolerated by patients and has been shown to improve outcomes in patients with bladder cancer.
Predictive biomarkers are being increasingly used in oncology...2022-11-1608 min
The Pig Microbiome Podcast#SHORTS: The future of biomarkers of pig's intestinal healthDid you know that the pig’s microbiota has more than 400 species of fungi and bacteria yielding approximately 10 times more cells than those in the pig’s body? These microbes are at the nexus of health and productivity as they communicate with each other and with the pig’s organs and systems.
Phileo by Lesaffre is committed to pushing the boundaries of animal health, nutrition, and well-being to better nourish and feed our world. United with our partners, we are key influencers in the quest to discover, define, and manipulate the pig’s microbiome to significantly improve pig lifeti...2022-09-0803 min
The MedTalk PodcastAI biomarkers and the effects of treating lung diseaseIan Bolland, acting group editor of life sciences at Rapid News Group, is joined by Susan Wood, president and CEO of Vida Diagnostics.
They talk about the spotlight that has been put upon respiratory disease amid the COVID-19 pandemic, challenges faced in respiratory clinical trials, the crucial role data can play, and the focus that needs to be put upon treating lung disease to bring down mortality rates.
This podcast is sponsored by Arena, a PTC business. For more information, visit: https://www.arenasolutions.com2022-08-2626 min
The Pig Microbiome Podcast#09 - Pigs microbiome and biomarkers within the intestinal mucosa microbiome - Dr. Sung Woo KimDid you know that the pig’s microbiota has more than 400 species of fungi and bacteria yielding approximately 10 times more cells than those in the pig’s body? These microbes are at the nexus of health and productivity as they communicate with each other and with the pig’s organs and systems.
Phileo by Lesaffre is committed to pushing the boundaries of animal health, nutrition, and well-being to better nourish and feed our world. United with our partners, we are key influencers in the quest to discover, define, and manipulate the pig’s microbiome to significantly improve pig life...2022-08-1147 min
Remember MeFTD Research Mini-Series: All About Fluid Biomarkers with Dr. Adam Boxer of UCSFIt's our last episode of our dementia research mini-series! And as a follow up to our recap of Day 4, we interviewed Dr. Adam Boxer to learn more about fluid biomarkers - AKA - we ask him all about what the bloodwork and lumbar puncture is used for.
Stay tuned for a very special ending of our 8-part series. Thank you for coming on the journey with us and please let us know what you think of this series by reaching out to us on our website! www.remembermeftd.com
Adam L. Boxer, MD, PhD, is...2022-06-3029 min
The Radcliffe Cardiology PodcastEp 6: Inflammatory Biomarkers and Cardiovascular RiskWhat are the clinical challenges in the use of biomarkers to estimate the risk of a cardiovascular event?
Join Dr Bruna Gigante (Karolinska Institute, Solna, SE) in a discussion of potential biomarkers which may impact a patient’s cardiovascular risk profile. In this month’s featured author episode of the ECR Podcast, Dr Gigante discusses novel biomarkers and the clinical challenges which may be faced when estimating a patient’s cardiovascular risk.2022-06-2928 min
THE ONE'S CHANGING THE WORLD -PODCASTBCI- PERSONALISED PRECISION PSYCHIATRIC MEDICINE - DR. AKSHAY SUJATHA RAVINDRAN- ALTO NEUROSCIENCE#neuroscience #braincomputerinterface #precisionmedicine #artificialintelligence
PERSONALISED PRECISION PSYCHIATRIC MEDICINE
Dr. Akshay Sujatha Ravindran is a Data Scientist at Alto-Neuroscience Alto Neuroscience is redefining psychiatry by developing personalized and highly effective medicines to help patients get better faster. Our artificial intelligence (AI)-enabled platform measures biomarkers like EEG and wearable data, behavioral patterns, genetics, and other factors to match patients with the treatment they are most likely to respond to. Our approach matches the right patient with the right Alto drug based on AI-derived brain biomarkers, redefining psychiatry at a time when the world needs it most.
2022-06-2749 min
OncotargetBehind the Study: IGF-pathway Biomarkers and Lung CancerDr. Alexander Pohlman from Rush Medical College, Rush University Medical Center, Chicago, IL, describes a recent review published by Oncotarget that he co-authored entitled, “The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer.”
DOI - https://doi.org/10.18632/oncotarget.28202
Correspondence to - Jeffrey A. Borgia - jeffrey_a_borgia@rush.edu
Abstract
Background: Detection rates of early-stage lung cancer are traditionally low, which contributes to inconsistent treatment responses and high rates of annual cancer deaths. Currently, low-dose computed tomography (LDCT) screening produces a high false discovery rate. This limitation has prompted research to identify biomarkers to m...2022-06-1404 minAging-USAnnouncement: Sponsoring Systems Aging Gordon Research ConferenceBUFFALO, NY- May 24, 2022 – Aging (Aging-US) is sponsoring the Systems Aging Gordon Research Conference, “Systemic Processes, Omics Approaches and Biomarkers in Aging,” from May 29 to June 3, 2022, at the Grand Summit Hotel at Sunday River in Newry, Maine, USA.
This year, the Chair and Vice Chair of the conference are Aging Editorial Board members Vadim N. Gladyshev, Professor of Medicine at Harvard Medical School and Director of Redox Medicine at Brigham and Women’s Hospital, and Steve Horvath, Professor of Human Genetics and Biostatistics at the University of California, Los Angeles. Dr. Gladyshev is known for his characterization of the human selenoproteome. He was a...2022-05-2503 min
EMEUNET PodcastWhat Is New? - February 2022 - Episode 12 "Biomarkers for PsA treatment response and more!"If you are too busy to read the EMEUNET What Is New contributions (https://emeunet.eular.org/what_is_new.cfm), this podcast is exactly for you. Now you can get updated while on the go, with highlights of the most recent publications in the field of Rheumatology, selected for you by EMEUNET members.2022-04-2816 min
Keeping Current CMEState of the Art Care in Alzheimer's Disease: Exploring the Role of BiomarkersAre you up to date on how the field of Alzheimer's disease diagnosis is changing? Learn about current and emerging biomarkers of Alzheimer's disease. Credit available for this activity expires: [04/01/23] Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/971142?src=mkm_podcast_addon_9711422022-04-0135 min
Aging-USTrending With Impact: Do Biomarkers of “Long COVID” Exist?Listen to a blog summary of a trending research paper published by Aging (Aging-US) on February 16, 2022, entitled, “Elevated levels of serum CDCP1 in individuals recovering from severe COVID-19 disease.”
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Among people who have been fortunate to recover from COVID-19, at least 40% had or have long-term lingering effects from this disease. Sometimes appearing months after recovering, these “long covid” effects can include (not limited to) fatigue, trouble sleeping, difficulty concentrating, joint or muscle pain, and respiratory issues, such as shortness of breath and chest pain. Researchers are still unsure as to whether or not lasting COVID-19 effects in the lungs are associat...2022-03-1106 min
Precision Health and PGx PodcastPharmacogenomics Changed My Life: A Patient’s Story, Kristen Ruth Davis | PGX For PharmacistsThanks for joining us today as our host, Dr. Jamie Wilkey talks with a patient, Kristen, who strongly feels that PGx testing saved her life.
Join us for a patient’s side of the story today!
You may reach Kristen at her website: https://www.imnotcrazyproject.org/ her Facebook page: https://www.facebook.com/imnotcrazyproject or on LinkedIn: https://www.linkedin.com/in/kristen-ruth-davis-5540142a/
You may reach Jamie at her website: drjamiewilkey.com or on her LinkedIn page: https://www.linkedin.com/in/dr-jamie-wilkey/
*This episode discusses mental health and suicidal ideation. While it is not discussed in great det...2022-03-0740 minKeeping Current CMEImproving Recognition of Heart Failure in Patients With Type 2 Diabetes: Prognostic Implications of Cardiac BiomarkersDoes your patient with diabetes also have heart failure? Find out more about the use of cardiac biomarkers with Dr Januzzi and experts. Credit available for this activity expires: 2/25/2023 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/969035?src=mkm_podcast_addon_9690352022-02-2834 min
TPN Show Coverage HealthiMediSync: 90%+ early detection accuracy of Alzheimer’s @ CES 2022If you’ve ever been around someone with a mental disorder, such as Alzheimer’s or other forms of dementia, you know it can be hard for everyone involved. Watching a loved one disappear into a fog of confusion and often anger is emotionally distressing for the caretakers and family. Unfortunately, there has not been any way to detect these issues early on with efficiency, making it difficult to treat before the disease progresses beyond repair. However, iMediSync has a new product to do just that.
Who is iMediSync?
iMediSync has developed a ground-breaking earl...2022-02-1115 min
Aging-USDNA Methylation-based Measures of Biological AgeAging-US published "DNA methylation-based measures of biological age: meta-analysis predicting time to death" in 2016, which reported that estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans.
These authors previously demonstrated that independent of chronological age, epigenetic age assessed in blood predicted all-cause mortality in four human cohorts. Here, they expanded their original observation to 13 different cohorts for a total sample size of 13,089 individuals, including three racial/ethnic groups. In addition, they examined whether incorporating information on blood cell composition into the...2022-01-0414 min
OncotargetNew Study: Biomarkers Linked to the Progression of Endometrial CancerStatistics from the American Cancer Society indicate that endometrial cancer (EC) is on the rise among women in the United States. While it more commonly affects older women, researchers are finding that EC is the only gynecological cancer today increasing in incidence and mortality among younger women. Not to be confused with the benign condition of endometriosis, EC tumors are highly heterogeneous and are a challenge to diagnose and treat. Since these heterogeneous tumors also develop in differential growing environments, most studies that use EC cell lines to diagnose patients or develop treatments do not translate to efficacy in vivo.
“Cu...2021-12-2406 min
Aging-USCan Hormone Therapy Improve Aging?Men and women universally experience a decrease in sex hormones with age. Given this knowledge, researchers previously conducted a study to assess the correlation between aging, estrogen levels and the release of glycans (carbohydrate-based polymers) among all proteins in the body. Glycans are also important components of immunoglobulin G (IgG). IgGs are serum antibodies which provide immune protection against bodily infections and mediate systemic inflammation. Each IgG molecule usually includes about 3% glycans. However, changes in the composition of glycans attached to IgGs can significantly influence antibody activity. A decrease in galactosylation has been correlated with the onset of disease and...2021-12-1006 min
Aging-USEffects of Estradiol on Biological Age Measured Using the Glycan Age IndexAging-US published "Effects of estradiol on biological age measured using the glycan age index" which reported that glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G.
In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while some studies suggested that glycan changes precede development of several age-associated diseases. In this study the authors evaluated effects of estrogen on the glycan age. After the recovery period glycan age returned to baseline values in both groups.
These results suggest that IgG glycans and consequently also the glycan age are under strong influence of...2021-11-0208 min
Aging-USAn Immune Subtype of Uveal Melanoma With a Poor PrognosisAging-US published a Special Collection on Eye Disease which included "Immunological analyses reveal an immune subtype of uveal melanoma with a poor prognosis" which reported that uveal melanoma is an aggressive intraocular malignancy that often exhibits low immunogenicity.
Metastatic uveal Melanoma samples frequently exhibit monosomy 3 or BAP1 deficiency. In this study, the authors used bioinformatic methods to investigate the immune infiltration of uveal melanoma samples in public datasets.
The Kaplan-Meier method and log-rank test were used to assess the prognostic value of particular immune cells and genes in samples. These authors used CIBERSORT and ESTIMATE with RNA-seq data from The...2021-11-0101 min
wise athletes podcastPersonalized Health & Athletic Performance with Gil Blander, PhDThe Science and Practice of Extending Healthspan and Athletic Performance Longevity for Older Athletes via Biomarker and DNA Analysis
Today’s WiseAthletes episode is with one of the leading minds in the basic biology of aging and translating scientific discoveries into new ways of detecting and preventing age-related conditions. Gil Blander, PhD. Gil is the founder of InsideTracker, the only fitness program that analyzes a sample of blood and, in conjunction with your DNA and your wellness and lifestyle goals, provides a personalized diet, nutrition, exercise plan, which is best for your body and your goals.
2021-08-0948 minwise athletes podcast#35 - Personalized Health & Athletic Performance with Gil Blander, PhD
The Science and Practice of Extending Healthspan and Athletic Performance Longevity for Older Athletes via Biomarker and DNA Analysis
Today’s WiseAthletes episode is with one of the leading minds in the basic biology of aging and translating scientific discoveries into new ways of detecting and preventing age-related conditions. Gil Blander, PhD. Gil is the founder of InsideTracker, the only fitness program that analyzes a sample of blood and, in conjunction with your DNA and your wellness and lifestyle goals, provides a personalized diet, nutrition, exercise plan, which is best for your body and your goals.
2021-08-0948 minwise athletesPersonalized Health & Athletic Performance with Gil Blander, PhDThe Science and Practice of Extending Healthspan and Athletic Performance Longevity for Older Athletes via Biomarker and DNA Analysis
Today’s WiseAthletes episode is with one of the leading minds in the basic biology of aging and translating scientific discoveries into new ways of detecting and preventing age-related conditions. Gil Blander, PhD. Gil is the founder of InsideTracker, the only fitness program that analyzes a sample of blood and, in conjunction with your DNA and your wellness and lifestyle goals, provides a personalized diet, nutrition, exercise plan, which is best for your body and your goals.
2021-08-0948 min
OncotargetOncotarget: Biomarker Predicts Treatment Efficacy in Triple-Negative Breast CancerBiomarkers are any measurement in the body that can indicate disease, infection, or effects of the environment. These indicators are commonly used to reveal disease, but they can also be used to support personalized cancer therapy.
“In recent years, there has been an increased focus on personalized cancer therapy. One important aspect is the identification of key biomarkers that support a given treatment plan.”
Multiple biomarkers have been identified in breast cancers as helpful tools to guide targeted therapies, including the expression of HER2 and estrogen and progesterone receptors. In triple-negative breast cancer (TNBC), a number of distinct biomarkers have given ri...2021-07-2805 min
The Pig Microbiome Podcast#06 - Tonsil microbiome, Identifying biomarkers, and Microbiota analytics process - Dr. Vahab Farzan and Dr. Lamya RhayatDr. Vahab Farzan, DVM, MSc, PhD, is at the Ontario Veterinary College, University of Guleph. Farzan's research interests include epidemiology of food-borne pathogens and infectious diseases in swine.
Dr. Lamya Rhayat is currently Team Manager & Senior Scientist Animal Microbiota at Phileo by Lesaffre. She has a MS and PhD in Microbiology at University Pierre et Marie Curie (France).
*This podcast is operated by Swine Impact, a Swine it Company.2021-07-271h 14
BIOmarkers PodcastSeason 2 - Episode 4 - Dr. Kenneth Eric PetersIn this episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Ken Peters, an adjunct professor in the Department of Geological Sciences at Stanford University, Fellow in the Geochemical Society, and principal author of The Biomarker Guide. In this episode, Ken discusses his career insights and the importance of lifelong learning and teaching.2021-07-0852 min
BIOmarkers PodcastSeason 3 - Episode 3 - Susan GainesIn the third episode of season 2 of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Susan Gaines, author of Carbon Dreams and co-author of the organic geochemistry staple, Echoes of Life. In this episode, Susan covers her journey through science and writing Carbon Dreams and Echoes of Life. She also mentions her newest book, The Accidentals.2021-07-0718 min
OncotargetOncotarget: Novel Urine Protein Biomarkers In Bladder CancerOncotarget published this trending research paper on April 13, 2021, entitled, "Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens" conducted by researchers from the University of Houston and UT Southwestern Medical Center.
Bladder cancer is four times more common among men than women, and it is the sixth most common cancer diagnosis in the United States. However, researchers have found that cystoscopy—the primary method physicians use to diagnose patients with bladder cancer—is relatively invasive, expensive, and has the potential to cause urinary tract infections.
“In contrast, urine is a noninvasive and readily available biological fluid that can be use...2021-06-0404 min
OncotargetOncotarget: A New Potential Network of Biomarkers Useful Across SarcomasIn the cover paper of this week's issue of Oncotarget (Volume 12, Issue 8), titled, "Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas," researchers examined five potential biomarkers across 18 different histologic subtypes of sarcoma in 163 tissue samples. Immunohistochemical staining, statistical analysis, and correlation-based network analysis revealed promising results.
Researchers from the University of Iowa, University of Alabama at Birmingham, and the Mayo Clinic, report the need for additional prognostic and therapeutic biomarkers to predict clinical behavior across different histological types of sarcoma.
“Although the French (FNCLCC) and NCI grading schemes have been adopted for ma...2021-04-1508 min
OncotargetOncotarget: Quantitative Proteome Profiling Stratifies Fibroepithelial Lesions Of The BreastOncotarget published "Quantitative proteome profiling stratifies fibroepithelial lesions of the breast" which reported that the current grading system remains unreliable in differentiating these tumors due to histological heterogeneity and lack of appropriate markers to monitor the sudden and unpredictable malignant transformation of PTs.
The high- throughput quantitative proteomic analysis suggested that FAD and PTs form distinct clusters away from borderline and malignant though there exist marked differences between them.
Interestingly, over-expression of extracellular matrices related proteins and epithelial-mesenchymal transition markers in borderline PTs led these authors to hypothesize a model of deposition and degradation leading to ECM remodeling and EMT...2021-03-1804 min
BIOmarkers PodcastSeason 2 - Episode 2 - Dr. Stuart WakehamIn the second episode of season 2 of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Stuart Wakeham, professor emeritus at the Skidaway Institute of Oceanography. In this episode, Stuart covered how he got into organic geochemistry, his experiences in research, and his insight on making career decisions2021-03-1220 minBIOmarkers PodcastSeason 2 - Episode 1 - Dr. John FarringtonIn the first episode of season 2 of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. John Farrington, dean emeritus from the Woods Hole Oceanographic Institute. In his interview, John discusses his career, his exciting research experiences, and his goings on after “failing!” retirement.2021-02-2620 min
BIOmarkers PodcastEpisode 9 - Dr. Cindy LeeIn the ninth episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Cindy Lee, a professor emeritus at the Stony Brook School of Marine and Atmospheric Sciences. In her interview, Cindy discusses how she got into organic geochemistry, oceanography, and her advice for folks pursuing science today.2020-12-0413 minBIOmarkers PodcastEpisode 8 - Dr. Katherine H. Freeman - Part 2In the eighth episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak again with Dr. Katherine Freeman, an organic and isotope geochemist in the Department of Geosciences at Penn State University. In part one of her interview, Kate shared with us her pathway to science, her research, and the power of curiosity. In part two of her interview, Kate shares with us her commitment to writing, managing a lab, and the importance of good questions.2020-11-1310 minBIOmarkers PodcastEpisode 7 - Dr. Katherine H. Freeman - Part 1In the seventh episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Katherine Freeman, an organic and isotope geochemist in the Department of Geosciences at Penn State University. In part one of her interview, Kate shares with us her pathway to science, her research, and the power of curiosity.2020-10-3011 min
Singapore Medical Journal Podcast2020 Ep 1: Ovarian biomarkers in IVFAuthor Dr Ryan Lee shares his insights on his team’s research on biomarkers for controlled ovarian stimulation response.
Read the article: Ovarian biomarkers predict controlled ovarian stimulation for in vitro fertilisation treatment in Singapore2020-10-3007 minBIOmarkers PodcastEpisode 6 - Dr. Christopher M. ReddyIn the sixth episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Christopher Reddy, he is a senior scientist and the Stanley W. Watson chair in Oceanography at the Woods Hole Oceanographic Institute. In his interview, Chris discusses his early life, pathway into the field of organic geochemistry, and his work on organic contaminants in coastal and oceanic waters.2020-10-1617 minBIOmarkers PodcastEpisode 5 - Dr. Kliti GriceIn the fifth episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Kliti Grice, who leads the Western Australian Organic and Isotope Geochemistry Centre as the John Curtin Distinguished Professor at Curtin University in Perth, Australia. In her interview, Kliti discusses her pathway to research, her colleagues in the field, and the qualities she thinks all good geochemists have.2020-10-0214 min
Big Feed up HQTesting Key Biomarkers in Autumn & Winter / Vitamin D / Solo ShowTesting biomarkers in Autumn & Winter such as Cholesterol and subsets (LDL, HDL,Triglycerides,) B12, Calcium, Ferritin, Vitamin D and HbA1c (average reading of glucose levels over duration of 2-3 months)and things to consider.
Testing tools to consider.
Dietary interventions to consider.
As always if you like the show please share it with someone and subscribe on SoundCloud, Apple Podcast and Spotify. If you could do me a solid and leave a review and a rating on any of those platforms that would be very kind.
Links and Resources:
NHS advice - https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/
...2020-09-3022 minBIOmarkers PodcastEpisode 4 - Dr. Simon BrassellIn the fourth episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Simon Brassell, Professor of Geological Sciences, Biogeochemistry, and Molecular Organic Geochemistry at the Department of Earth and Atmospheric Sciences at Indiana University Bloomington. In his interview, Simon discusses his time at the University of Bristol, proxies, and what piques his interest today.2020-09-1800 minBIOmarkers PodcastEpisode 3 - Dr. Sylvie DerenneIn this episode of BIOmarkers, the series that explores the history of organic geochemistry, we speak with Dr. Sylvie Derenne, winner of the 2019 Alfred Treibs Award at the International Meeting on Organic Geochemistry and senior scientist at the French National Center for Scientific Research. In our interview with Dr. Derenne, she tells us about how she ended up in organic geochemistry, her research, and what she thinks makes a good organic geochemist.2020-09-0400 minBIOmarkers PodcastEpisode 2 - Dr. Timothy Ian EglintonIn the second episode of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Tim Eglinton, Professor of Biogeoscience at ETH Zurich and Fellow of the Royal Society well-known for his work on the carbon cycle. In his interview, Tim covers his path into the field, his research, and he speaks about his father, Geoffrey Eglinton.2020-08-2100 minBIOmarkers PodcastEpisode 1 - Dr. Clifford WaltersIn the premiere of BIOmarkers, the audio series that archives the oral history of organic geochemistry, we speak with Dr. Clifford Walters, a career industry expert currently at ExxonMobil. Cliff discusses his early days as a student, how he got into the field of organic geochemistry, and gives his advice to early career researchers about the future of the field.2020-08-0700 min
OncotargetOncotarget Podcast - A 3D Biofabricated Cutaneous Squamous Cell Carcinoma Tissue ModelThe cover for issue 27 of Oncotarget features Figure 4, "(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.
Fluorescence-derived imaging biomarkers indicated that 50% of cancer cells were killed in the tissue after 1μM 5-Fluorouracil 48-hour treatment, compared to a baseline of 12% for untreated controls.
The imaging biomarkers also showed that normal keratinocytes were less affected by treatment than the untreated tissue, w...2020-07-0403 min
OncotargetOncotarget Podcast: Clonality and antigen-specific responses shape prognostic effectsOncotarget Volume 11, Issue 27 published "Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer" by Tsuji et al. which reported that to delineate the complexity of anti-tumor T-cell responses, the author's utilized a computational method for de novo assembly of sequences from CDR3 regions of 369 high-grade serous ovarian cancers from TCGA, and then applied deep TCR-sequencing for analyses of paired tumor and peripheral blood specimens from an independent cohort of 99 ovarian cancer patients.
In the validation cohort, the authors' discovered that patients with low T-cell infiltration but low diversity or focused repertoires had clinical outcomes...2020-07-0404 min
OncotargetOncotarget Podcast - A 3D Biofabricated Cutaneous Squamous Cell Carcinoma Tissue ModelThe cover for issue 27 of Oncotarget features Figure 4, "(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.
Fluorescence-derived imaging biomarkers indicated that 50% of cancer cells were killed in the tissue after 1μM 5-Fluorouracil 48-hour treatment, compared to a baseline of 12% for untreated controls.
The imaging biomarkers also showed that normal keratinocytes were less affected by treatment than the untreated tissue, w...2020-07-0403 min
OncotargetOncotarget Podcast: Clonality and antigen-specific responses shape prognostic effectsOncotarget Volume 11, Issue 27 published "Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer" by Tsuji et al. which reported that to delineate the complexity of anti-tumor T-cell responses, the author's utilized a computational method for de novo assembly of sequences from CDR3 regions of 369 high-grade serous ovarian cancers from TCGA, and then applied deep TCR-sequencing for analyses of paired tumor and peripheral blood specimens from an independent cohort of 99 ovarian cancer patients.
In the validation cohort, the authors' discovered that patients with low T-cell infiltration but low diversity or focused repertoires had clinical outcomes...2020-07-0404 min
OncotargetOncotarget: Anticancer Effect Of Physical Activity Is MediatedVolume 11, Issue 22 of Oncotarget reported that the goal of this study was to explore the involvement of mi RNAs in beneficial effects exerted by physical activity in breast cancer prevention.
The levels of extracellular mi RNAs were evaluated in blood plasma before and after structured exercise by means of microarray analysis of 1,900 mi RNAs identifying mostly modulated mi RNAs. The different expressions of two mi RNAs involved in breast cancer progression, i. e. up-regulation of mi R-206 and down-regulation of anti-miR-30c, were the most striking effects induced by exercise.
The biological effects of these mi RNAs were investigated in...2020-06-0303 min
The Pacing and Racing PodcastJonathan Levitt: How biomarkers can be your roadmap to optimal performanceSo as the year 2020 has an ever-changing landscape with COVID 19 and race events cancelling globally I felt the need to react accordingly with the Podcast. I know we will eventually get back into the race season; we just simply don’t know when and because of that it may be disheartening and difficult to find motivation to put in those long hours preparing for an IRONMAN.
Not only that, but in a time where a virus runs ramped in our society I think the last thing we want to do is put anymore pressure on our immune sy...2020-04-2137 min
PAINWeek PodcastsBrain Based Biomarkers for PainObjective Measures of Pain or a Journey Down the Rabbit Hole?
Using functional magnetic resonance imaging (fMRI) techniques, we have been able to open windows to the brain, to noninvasively study its structure and function. Pain processing within the central nervous system (CNS), brain and spinal cord, and how it is disrupted in chronic pain has been increasingly characterized using neuroimaging. However, to date, fMRI has provided minimal direct clinical application for pain. We believe that will soon change. Furthermore, the use of more sophisticated analysis techniques is providing us with greater mechanistic understanding of the role of the brain...2019-03-2749 min
Health LabElevated Brain Injury Biomarkers in Football Players | Michigan MedicineEven without symptoms of concussion, researchers studying high school football players found two elevated biomarkers that are associated with brain injury.To learn more about this story visit: https://labblog.uofmhealth.org/lab-report/football-head-impact-raises-biomarkers-for-brain-injury Hosted on Acast. See acast.com/privacy for more information.2018-07-1201 min
The St.Emlyn’s PodcastEp 99 - October 2017 Round Up
Navigating the Landscape of Emergency Medicine: Insights from St. Emlyn's
Welcome to St. Emlyn's, your go-to resource for the latest in emergency medicine. Our recent discussions cover a range of topics, from evolving communication strategies in major incidents to the nuances of managing chronic health issues among healthcare professionals. Let's dive into key insights and updates from our blog and the recent College of Emergency Medicine conference.
Modernizing Major Incident Communication
Traditionally, emergency departments relied on landlines and telephone trees for major incident alerts. However, modern digital tools like WhatsApp, Facebook, and Twitter offer more...2017-10-2122 min
JDD Podcast: Ask the InvestigatorPatrolling Pemphigus: Identifying Biomarkers to Monitor for Disease ProgressionIn this edition of the JDD Podcast “Ask an Investigator,” host Dr. Adam Friedman speaks with Dr. Animesh Sinha, the Rita M. & Ralph T. Behling Professor and Chair of...
The post Patrolling Pemphigus: Identifying Biomarkers to Monitor for Disease Progression appeared first on JDDonline - Journal of Drugs in Dermatology.2017-02-0134 min
Podcast EpisodesEp. 295 – Dementia Biomarkers Part 3Happy Monday to our Train Your Brain Podcast listeners! Today we are going to continue our conversation the Biomarkers for Dementia with Part 3. The more markers we have the better we can predict how a person’s brain is working … Continue reading →2016-06-2022 min
Train Your Brain Podcast with Dr. Michael TrayfordEp. 295 â Dementia Biomarkers Part 3Happy Monday to our Train Your Brain Podcast listeners! Today we are going to continue our conversation the Biomarkers for Dementia with Part 3. The more markers we have the better we can predict how a personâs brain is working ⌠Continue reading â2016-06-2022 min