Shows
The Stem Cell Report with Janet RossantLeaving an Imprint: The Function, Impact, and Detection of Epigenetic MarksParent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 imprinted genes have been discovered, and improper imprinting can manifest in growth restriction, obesity, intellectual disabilities, behavioral abnormalities, and an increased risk of certain cancers. While the use of pluripotent stem cells, especially those in the naïve state, have advanced aspects of modeling early development, a persistent issue hampering bona fide naïve hPSCs is the erosion of imprints. Our guests on today's episode will discuss genomic imprinting, it...2025-04-0754 minThe Stem Cell Report with Janet RossantDon’t Dull the SPARCL: The Lung Microvasculature and its Role in DevelopmentThe mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological role in gas exchange within the tissue, but the vascular cells have additional role(s) beyond supplying oxygen and nutrients to the tissue. For example, the adult lung endothelium responds to injury by activating pathways for alveolar re epithelialization and during embryonic development, disrupting vascularization ex vivo affects the stereotypical pattern of airway branching, consistent with a perfusion-independent crosstalk between the endothelium and epithelium. Today’s guests explore the molecular contribution of ECs and...2025-03-2043 minThe Stem Cell Report with Janet RossantA Look Into the Future of Stem Cell Reports: A Conversation with Janet RossantIn this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees as some of the exciting prospects over the horizon for stem cell research. We will also talk with Yvonne Fisher, the journal’s Managing Editor, and Jack Mosher of the ISSCR, about the evolution of the journal and its role in the Society. GuestsJanet Rossant is the new Editor-in-Chief of Stem Cell Reports. She holds an appointment as the Chief of...2025-01-1357 minThe Stem Cell Report with Janet RossantSeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality AssessmentDuring the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, mutations, on-target and off-target editing errors, and microbial contamination can arise during PSC culture or due to undesired editing outcomes. To ensure valid experimental results and the safety of PSC-derived therapeutics, it is important to detect these abnormalities and choose PSC lines without them. Existing quality control methods typically focus on detecting one type of abnormality. Whole genome sequencing is an all-in-one...2024-12-0934 minThe Stem Cell Report with Janet RossantGuidelines for Managing and Using the Digital Phenotypes of Pluripotent Stem Cell LinesThe ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and disease. As a result, these cells are shared, edited, and differentiated by laboratories across the world for basic research, clinical translation, and commercial applications. Large and genotypically diverse collections of pluripotent stem cells are being generated to support large cohort-scale research into conditions such as Parkinson’s disease and amyotrophic lateral sclerosis, among many others. However, information about these cells, their derivatives, and the resulting data can be difficult to track du...2024-11-1253 minThe Stem Cell Report with Janet RossantPSC Developmental Bias: The Mechanism and the Variation in Human Neural DevelopmentPluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field that there is variability in developmental potential between cell lines. This phenomenon, sometimes referred to as lineage bias, is manifest in a variable response of individual cell lines to induction of differentiation into a specific germ layer lineage. Although lineage bias in pluripotent stem cells has been reported for some years, we do not fully understand its molecular basis, or its implications for normal development. The guests on today’s program st...2024-10-2542 minThe Stem Cell Report with Janet RossantAging, Stem Cells, and Biological ClocksEpigenetic clocks based on tissue DNA methylation analysis have emerged as robust and powerful biomarkers of aging. This technology has allowed scientists to investigate how diseases affect the aging process, to evaluate the effectiveness of therapeutic aging interventions, and to correlate age with overall health among the general public. Today you can even purchase test kits online that enable you to measure your own biological age. However, despite the growing use of epigenetic clocks in research, surprisingly little is known about the aging clock’s cellular underpinnings. For example, it remains unclear whether all cells within a tissue exhibit the...2024-09-1039 minThe Stem Cell Report with Janet RossantEvaluating the Expanding Models of Brain DiseaseThose who study neurological diseases and their underlying cellular and molecular mechanisms have a number of scientific models at their disposal. In vivo animal models, particularly those bearing targeted genetic modifications, remain the gold standard, especially when it comes to assessment of behavioral readouts and neurobiological disease mechanisms in vivo. Historically, animal models have been widely used for preclinical validation of drug efficacy and safety. Increasingly there is a move away from this approach, and human cellular models using induced pluripotent stem cells and their derivatives such as three-dimensional organoid models have recently provided unprecedented genetic and m...2024-08-1251 minThe Stem Cell Report with Janet RossantGoing Out on a LIM: Rethinking the Role of LMX1A in Patterning Dopaminergic NeuronsThis episode of The Stem Cell Report will discuss the process of directing stem cells to acquire the proper identity, an essential step in the development of effective and durable cell replacement therapies. Specifically, we will talk about the process of directing cells into a ventral mesencephalic dopaminergic fate for treating Parkinson’s disease. GuestsAgnete Kirkeby is an Associate Professor in the Department of Neuroscience at the University of Copenhagen, a Principal Investigator with the Novo Nordisk Foundation Center for Stem Cell Medicine renew, and a Principal Investigator at the Wallenberg Cen...2024-06-1130 minThe Stem Cell Report with Janet RossantNo Oligo Monopoly: Oligodendrocyte Precursor Cells in the Developing CortexMyelination is one of the last events during mammalian brain development and is thought to continue into young adulthood in humans. Even in adulthood, ongoing low-level myelination is essential for neural homeostasis, and for dynamic processes such as learning and memory. Deficits in myelination resulting in abnormal white matter and disruption of neuronal function are observed in a wide variety of disorders of the CNS. One strategy for alleviating these deficits is to enhance the genesis of myelin-forming oligodendrocytes from their upstream precursor parents, oligodendrocyte precursor cells (OPCs). However, the capability of these OPCs to contribute to remyelination in...2024-05-2037 minThe Stem Cell Report with Janet RossantClimbing the Scientific Mountain of Retinal RegenerationCollectively, retinal degenerative disorders are a major cause of blindness worldwide. For example, one of the most common disorders is age related macular degeneration, which alone affects nearly 200 million globally. In humans, and other mammals, the loss of the retinal cells is an irreversible process. However, in some non-mammalian vertebrates like frogs and fish, retinal neurons can regenerate. This process is dependent upon Müller glia, which can re-enter the cell cycle and reprogram into neurogenic progenitors upon retinal injury or disease. Progress has been made in understanding the genetic program underlying these regenerative process, and proof-of-principle ex...2024-03-1143 minThe Stem Cell Report with Janet RossantHuman Fetal Tissue: A Legacy of Biomedical Research ContributionsSince the 1930’s research using human fetal tissue has been used in numerous scientific and medical advances that have saved millions of lives, including the development of vaccines and treatments for diseases. Despite its substantial contribution to medicine and science, significant public debate and misinformation persists surrounding the ethical use of human fetal tissue in biomedical research. The ISSCR, led by its Public Policy Committee, have been tireless champions and advocates for sound science policy across the globe. This includes advocacy for fetal tissue research and working to inform policymakers and the public on the vast medical app...2024-02-1237 minThe Stem Cell Report with Janet RossantThe Selling of Stem CellsThis November marks the 25th anniversary of the successful isolation and culture of human embryonic stem cells by Jamie Thompson. This breakthrough was a turning point in biomedical research. This discovery provided scientists with a limitless source of human cells to understand human biology and model disease. The discovery also provided a novel pathway to develop tissues and cells that could potentially be used to provide curative diseases like diabetes and Parkinson’s, among others. To date, numerous companies are advancing human embryonic stem cell-based therapies in over 50 approved and regulated clinical trials. However, in parallel to the...2023-11-1348 minThe Stem Cell Report with Janet RossantSetting the Standards for Human Stem Cell ResearchHuman stem cell technology has led to remarkable insights into human biology in health and disease. However, for the results and outputs from this research to be accurate, meaningful, and durable, it is important that the field have agreed upon standards that ensure reproducibility and reliability of the data. The International Society for Stem Cell Research (ISSCR) has developed a set of recommendations, including reporting criteria, for scientists in basic research laboratories. These criteria are designed to be technically and financially feasible and, when implemented, to enhance the reproducibility and rigor of stem cell research. The guests o...2023-09-1252 minThe Stem Cell Report with Janet RossantOrganoids: Multi-Dimensional Standards for Three Dimensional ModelsThe use of organoids as an experimental system is rapidly advancing in pace and complexity. Derived from pluripotent or tissue stem cells, organoids are three-dimensional, in vitro, structures intended to model functional or developmental aspects of in vivo organs. They are also being used to model complex physiological systems in organ-on-chip devices and in assembloids, the combination of organoids from different tissues. Organoids are especially useful to model and understand aspects of human biology and pathology. This approach has led to much hope, and proof-of-principle findings, that these structures can serve as human avatars to advance the discovery of...2023-08-0738 minThe Stem Cell Report with Janet RossantBrushing Up on Tooth Biology: New Tools for Understanding Tooth DevelopmentWhile teeth have evolved over millions of years, scientists are still working to understand how teeth develop, a process formally known as Odontogenesis. Our guests today have developed a new model of mouse tooth development using long-term expandable 3D tooth organoids from postnatal mouse molars and incisors. This novel mouse model provides a valuable tool to study mouse tooth dental epithelial stem cells, dental epithelial-mesenchymal interactions, and differentiation processes, while allowing further elucidation of tooth type-specific features. These models, in combination with human tooth organoids, have great potential to further unravel tooth biology and repair and may be an...2023-07-1054 minThe Stem Cell Report with Janet RossantThe Satellite View: Muscle Stem Cells and Muscle DiseaseOver the last 10 years of Stem Cell Reports, the journal has published nearly 2,000 papers across the breadth of stem cell research. In this special episode of the podcast, we are celebrating the anniversary of the journal by talking with the authors from some of the most highly cited publications in the journal's history.The guests on this episode of the podcast have collective expertise that makes them the “dream team” of muscle stem cell biology and its application to treat disease. Akitsu Hotta is a Principal Investigator and Associate Professor in the Department of Cli...2023-05-1635 min
Backpacking Light PodcastEpisode 81 | Unresting EventIn this episode of the Backpacking Light Podcast, Ryan interviews Ben Kilbourne about his recent album, Unresting Event, and they discuss creating in the backcountry while sharing two songs from the album. To view the show notes for this podcast, click here. 2023-05-1541 minThe Stem Cell Report with Janet RossantFocusing on the Aberration: Learning From PSCs Chromosomal AbnormalitiesHuman pluripotent stem cells have an unlimited capacity to self-renew in culture. This feature, along with their ability to become any cell type in the adult body, makes them a unique tool to study human biology in health and disease. Unfortunately, human pluripotent stem cells have a propensity to acquire genetic abnormalities in culture that may limit their scientific and clinical use.Among the most prevalent genomic changes found in pluripotent stem cells are various forms of over-representation of sequences on the long arm of chromosome 20, with up to 20% of tested cultures containing such an aberration. One...2023-04-1148 minThe Stem Cell Report with Janet RossantPiWi – The Not-So-Small and Expanding Role of RNA Binding ProteinsThe PiWi family of genes may have a diminutive sounding name, but they have a large role in the function of the germline and germline stem cells. Initially discovered in Drosophila, these highly conserved RNA-binding proteins have well-established roles in the regulation of spermatogenesis and germ stem cell maintenance, in addition to silencing transposable elements. However, PiWi function outside of the germline is relatively unexplored. New findings from the Lin laboratory show that Drosophila Piwi has a role in intestinal homeostasis where it functions to establish intestinal stem cells, maintain the enteroblast lineage, and support of the enterocytes. It...2023-03-1339 minThe Stem Cell Report with Janet RossantLessons Learnt, and Still to Learn, in Stem Cell TrialsThis episode is sponsored by Bio-Techne. While advances in stem cell science have led to an increasing number of stem cell-based therapies entering clinical trials, the field is still relatively immature. Thus, these first-in-human trials are using pioneering approaches unique unto themselves, leaving scientists, physicians, and regulators to assess the best approaches for a specific therapy and/or disease. In this episode of the podcast, Martin Pera is joined by physician-scientists Roger Barker and Rajesh Rao who have and are leading stem cell-based trials to discuss some of the critical aspects of the process and reflect on t...2023-02-141h 11The Stem Cell Report with Janet RossantComputing Positional Cues: From Single Cells to Embryo DevelopmentThis episode is sponsored by Bio-Techne.Computational approaches have become integral to understanding biological processes, in part because of a need to come to grips with the enormous amounts of high dimensional data that we generate using our current tools for cellular analysis. This is especially relevant for stem cell and developmental biology where development, disease modeling, regulatory networks, and lineage formation all lend themselves to the combination of experimental and computational methods. Today’s program explores how computational biology approaches can be used to understand and model early development, specifically the lineage commitment of the early em...2022-12-1338 minThe Stem Cell Report with Janet RossantInterspecies Chimerism: Advances, Applications, and ChallengesThis episode of The Stem Cell Report will explore the scientific applications, advances, and challenges of interspecies chimeras – organisms consisting of cells from at least two different species. The development of interspecies chimeras, most recently advanced by the discovery of pluripotent stem cells and enhancements in genetic editing, have led to greater understanding of fundamental developmental and biological concepts, insight into evolution, and even the development of potential regenerative approaches for human health. Martin Pera will be joined by Drs. Ori Bar-Nur and Jun Wu, along with Joel Zvick, next generation scientists who are pioneering advances in interspecies chimera re...2022-10-1137 minThe Stem Cell Report with Janet RossantModeling Neuropsychiatric Disorders in a DishIn this episode of The Stem Cell Report, sponsored by Bio-Techne, we will explore the modeling of complex human neuropsychiatric diseases such as autism, bipolar disorder, and others using stem cell-based, three-dimensional culture models of the brain and its development. Martin Pera will be joined by Drs. Carol Marchetto and Rusty Gage, experts in the normal and pathological development of the brain. Carol Marchetto is an Assistant Professor in the Anthropology Department at the University of California, San Diego and an adjunct Assistant Professor at the Salk Institute. Rusty Gage is the Vi and John Adler Chair for Research...2022-09-1428 min
Waterpeople PodcastChelsea Woody: Cultivating KinshipFor many, 2020 was the worst. Chelsea Woody, a neuroscience nurse who moonlights as a Vans surf ambassador, is clear that it was “the worst year of her life.” After getting COVID from work, and subsequently experiencing a painful loss, — while witnessing the suffering of so many through the pandemic - Chelsea wished (for the first time) that she’d chosen a different profession.Parallel to the suffering both personal and all around her, Chelsea’s surfing career blossomed: she made the film Sea Us Now, and expanded the organisation she helped found, Textured Waves, interjecting the presence an...2022-08-261h 21The Stem Cell Report with Janet RossantThe ISSCR and Two Decades of Stem Cell AdvancesTo celebrate the ISSCR’s 20th anniversary, Martin Pera is joined by three members of the ISSCR Board of Directors; Fiona Doetsch (Biozentrum at the University of Basel, Switzerland), Clerk of the ISSCR, Takanori Takebe (Cincinnati Children's Hospital Medical Center, USA/Tokyo Medical and Dental University and Yokohama City University, Japan) is a Director, and Leonard Zon (Boston Children’s Hospital, USA) is an Ex Officio member, past president, and founder of the ISSCR. In addition to running their own laboratories these scientists are part of the ISSCR leadership and will talk about the ISSCR’s history, impact, the recent...2022-07-1038 min
Talk Birthy To MeBounce Back Culture, Body Image and ParenthoodThanks for listening today! This is something that is very near and dear to my heart as I have struggled with body image issues for as long as I can remember. Here were the things that we mentioned that can ben helpful:
Reframe our expectations
Purchase new clothes that fit your body right now
Practice mindfulness based exercises like gratitude practices, journaling, breathwork, yoga, meditation
Being more present with your baby and children
Talking to a therapist or counselor
Unfollow those on social media that make you...2022-06-1054 minThe Stem Cell Report with Janet RossantStem Cells in Translation: Focusing on the EyeIn this episode of The Stem Cell Report, Martin Pera is joined by three experts on the eye, its development, and disease processes. Dr. Mark Humayun is the Director of the Institute for Biomedical Therapeutics and Co-Director of the Roski Eye Institute at the University of Southern California. Dr. Anand Swaroop is a Senior Investigator in the Neurobiology, Neurodegeneration and Repair Laboratory at the National Eye Institute, and Dr. Masayo Takahashi is a pioneer in iPS-based approaches to treat eye disease and the President of Vision Care Inc., a venture that will focus on cell-based treatments for macular de...2022-05-2056 minBackpacking Light PodcastEpisode 59 | Ben Kilbourne Reads "Good Gear Lets You Be Present"We talk a lot about gear on this podcast. Gear is fun, and if you are a fan of this pod, you probably have an interest not only in if something works, but why it works. Still, it’s easy to begin to fetishize gear, to turn it almost into the point of having adventures rather than a tool to facilitate them. Don’t believe us? Just search "gear layout" hashtags on Instagram. That’s why we've always loved the essay “Good Gear Lets you be Present” by Ben Kilbourne. In his classic style, Ben struggles to balance hi...2022-04-1216 minThe Stem Cell Report with Janet RossantKeeping the Is(lets) on the Prize: Treating T1D with Stem Cell-based TransplantsIn this episode of The Stem Cell Report, Martin Pera is joined by Douglas Melton, a pioneer in the use of stem cell-based transplants to treat Type 1 diabetes, and Nayara Leite, a former postdoc in the Melton laboratory who now works for Vertex Pharmaceuticals, one of the companies currently testing stem cell-derived transplants for diabetes in clinical trials. Drs. Melton and Leite will talk about the concepts and issues around stem cell-based treatments for diabetes and their new paper that looks at ways to enhance the survival and function of the insulin producing islets.Guests2022-04-0137 minThe Stem Cell Report with Janet RossantWhen ROCK Stops the Roll: Explaining the Aging Neural Stem Cell NicheIn this episode of the Stem Cell Report, Martin Pera is joined by a team of scientists from the Neural Stem Cell Institute in Rensselaer, NY, USA. Drs. Elizabeth Fisher, Xiuli Zhao, and Institute Director Sally Temple talk about their new paper on neural stem and progenitor cell function in the aging adult brain. They use live time-lapse imaging with computer-based image analysis to assess young and aged neural stem and progenitor cells in 3D brain structures to assess the mechanism underlying changes to the aging brain. GuestsSally Temple, PhD, Neural Stem Cell In...2022-03-0835 minThe Stem Cell Report with Janet RossantBreathing Easier – Stem Cells and Lung FunctionIn this episode, Drs. Shimpei Gotoh, Takahiro Suezawa, and Carla Kim join the podcast to talk about using stem and progenitor cells to understand the adult lung and model disease processes impacting lung function. Their research and discoveries provide insight into lung homeostasis, the potential for regeneration, and understanding diseases like pulmonary fibrosis and cancer.Drs. Gotoh and Suezawa are two of the authors of the recent paper ”Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids” in Stem Cell Reports. Dr Kim is a member of the Stem Cell Reports Editorial Board and an e...2022-02-0838 minBackpacking Light PodcastBackpacking Light Podcast | Episode 53 | Ben Kilbourne Reads "Going Home"Backpacking Light contributor Ben Kilbourne reads his meditation on the transition from wilderness to trail to parking lot. Click here for show notes: https://backpackinglight.com/episode-53-going-home 2022-01-0316 minThe Stem Cell Report with Janet RossantLinking Genetic Variants to Cell Phenotypes in Human iPSCsIn this episode, Drs. Fiona Watt and Alice Vickers join the podcast to talk about uncovering the relationship between genetic variants and cellular behavior. They recently developed a platform to quantify iPSC differentiation propensity to investigate the genetic contribution to phenotypic variability. Drs. Vickers and Watt are authors of the recent paper, "Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation” in Stem Cell Reports. GuestsFiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London Website: http://www.wattlab.org/ Alice V...2021-11-0937 minThe Stem Cell Report with Janet RossantMending a Broken HeartIn this episode Drs. Charles Murry and Kenta Nakamura join the podcast to talk about “cardiac remuscularization therapy,” and the general approach of transplanting human pluripotent stem cell-derived cardiomyocytes to restore cardiac function after injury.GuestsCharles Murry, MD, PhD, University of Washington and Sana BiotechnologyKenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAXSupporting DocumentDrs. Murry and Nakamura are two of the authors...2021-10-1238 minThe Stem Cell Report with Janet RossantThe Intersection of Stem Cells and EngineeringIn this episode Drs. Peter Loskill and Christine Mummery join the podcast to talk about the intersection of stem cells, microphysiological systems and organs-on-a-chip technology in understanding disease, screening drugs and personalized medicine. Drs. Loskill and Mummery are guest editors of a special issue on this topic appearing now in Stem Cell Reports. GuestsPeter Loskill, PhD W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS). Twitter: @pe_loskChristine Mummery, PhD, Professor of...2021-09-2328 minThe Stem Cell Report with Janet RossantHans’ Iliad: Troy, Adult Stems, and the EpitheliaIn this episode, sponsored by Bio-Techne, Drs. Hans Clevers and Kai Kretschmar join the podcast to talk broadly about the role of adult stem cells in tissue maintenance and repair. Specifically, they will focus on the expression and function of Troy and stem cells in the development and homeostasis of the epidermis, the outermost layer of the skin, that functions as a protective mechanical and biological barrier against injuries, pathogens and the loss of heat and water.GuestsHans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem...2021-09-1338 minThe Stem Cell Report with Janet RossantTranscription Factor Dance Party - Building Dopaminergic NeuronsIn this episode, sponsored by bit.bio, Drs. Marius Wernig and Yi Han Ng join the podcast to talk about the directed differentiation of pluripotent stem cells into dopaminergic neurons. Their approach, which is based on the expression of specific transcription factors to drive cell fate directly to a specific neuronal identity, has been demonstrated to robust generalate functional dopaminergic neurons of midbrain character.GuestsMarius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford UniversityWebsite: https://www.werniglab.org/2021-08-0942 minBackpacking Light PodcastBackpacking Light Podcast | 043 | Observing Transition SeasonIn this episode of the Backpacking Light Podcast, author Ben Kilbourne uses the writing of Aldo Leopold to examine his motivations when exploring the backcountry. It's a thought-provoking essay that may just have you reconsidering why you are out there. Would you like to read the written version of this podcast? Check it out here. Click here for show notes: https://backpackinglight.com/episode-043-observing-transition 2021-08-0614 minBackpacking Light PodcastEpisode 40 |Story Short: The Anthropology of a TrailWho or what makes a trail? This is the question Backpacking Light author Ben Kilbourne asks himself (and us) as he reads his essay The Anthropology of a Trail. Click here for show notes: https://backpackinglight.com/episode-39-bikepacking 2021-06-1111 minThe Stem Cell Report with Janet RossantStem Cells: From Cancer Vaccines to Space ResearchIn today’s episode, we will talk about new research on the use of an induced pluripotent stem cell-based vaccine to potentially protect against pancreatic cancer. This approach takes advantage of shared antigens between stem cells and pancreatic cancer cells and seeks to exploit them for clinical benefit. We will talk with the authors of this new research published in Stem Cell Reports on why they decided to pursue this approach, the background behind it, and whether this approach could work for other types of cancers. We also discuss some of Dr. Wu's other work, including research on stem ce...2021-06-0730 minThe Stem Cell Report with Janet RossantThe Renaissance of Developmental BiologyIn this episode, we will talk about morphogenesis in embryo development, a process that in mammalians is known to show considerable plasticity. Understanding how this process is coordinated and how it responds to stress and physiological regulatory mechanisms provides us with a more complete picture of the regulation of mammalian development. We will talk with the authors of new research published in Stem Cell Reports on the regulation of embryo size and the timing of morphogenesis, critical early steps in embryonic development. Show NotesGuestsLorenzo Orietti, PhD – Medical Advisor, Onco-Hematology Unit, Amgen, Inc...2021-04-2337 min
The Stem Cell Report with Janet RossantBlastoids, Gastruloids, and Stem Cell-Based Embryo ModelsIn this episode Drs. Janet Rossant and Patrick Tam, join the podcast. They are experts in early embryonic development and authors of new Perspective article in Stem Cell Reports, Opportunities and Challenges with Stem Cell-Based Embryo Models. Embryo modeling is a rapidly emerging area of science which can help advance the understanding of early development, especially human development where insight has been limited due to technical and ethical issues. The article is online now and will appear in the May 2021 special issue of the journal.Show NotesGuestsJanet Rossant, P...2021-04-0141 min
In SiteCraig Childs - "The Madness of Disassociation"Craig Childs makes a point of going to the very places he’s writing about and immersing himself in them. In The Secret Knowledge of Water, he traces his very being into the rock itself by mapping waterholes in the Cabeza Prieta. In House of Rain, he follows the Ancestral Puebloans across the desert, walking in their footsteps to gain a particular kind of understanding. In Virga and Bone, he immerses himself in aridness and walks through it with curiosity directed at his very affinity for it. In Apocalyptic Planet he backpacks through cornfields in Iowa, among other similarly wi...2021-03-021h 12In SitePhotography as Medicine - Russel Albert DanielsThe Spanish enslavement of Indigenous peoples across the Southwest was an immense market in humans, second only to that of African Americans. Severed from their lands and cultures, how did some of them create a path forward? Who are the Genízaro? How can Catholicism and Indigenous traditions coexist, perhaps even synergize, in one community? And how can photography act as medicine?Today we talk with documentary photographer Russel Albert Daniels. He begins with the incredible story of his great great Grandmother Rose, who was captured from her Diné homeland by a band of Utes and sold to...2020-11-091h 05
CyberWire DailyCobalt Dickens, coming to a university library near you. UNICEF data exposure. Election security notes. Operation reWired arrests 281 alleged BEC scammers.Cobalt Dickens is back, and phishing in universities’ ponds. UNICEF scores a security own-goal. Patch Tuesday notes. A look at US election security offers bad news, but with some hope for improvement. The US extends its state of national emergency with respect to foreign meddling in elections. And an international police sweep draws in 281 alleged BEC scammers. Ben Yelin from UMD CHHS on the privacy implications of geofencing. Guest is Drew Kilbourne from Synopsys with result of their report, The State of Software Security in the Financial Services Industry.
For links to all of today's stories check our our CyberWire da...2019-09-1120 min
The Project EGG Show: Entrepreneurs Gathering for Growth | Conversations That Change The WorldDr. Lewis Kilbourne: Financial Executive Officer On Starting A BusinessLearning the process of starting a business is incredibly important for entrepreneurs. While most people think that it's sheer luck and randomness, the successful business owners learn from those who have already done it. In this interview, Dr. Lewis Kilbourne, CFO of 5 different publicly traded companies, shares his origin story of becoming a financial executive officer.
Dr. Kilbourne went to college out of high school and flunked out. He didn't know what to do so he went into the military. His time in the military taught him discipline and important skills that have helped him to be the businessman he...2017-10-2736 min
Your Life on Purpose28: Weekly Wrap UpHere’s what happened this week on Your Life on Purpose:
1. The Hero Inside All of Us
We embarked on The Hero’s Journey and are taking a close look at how it mirrors our live when we choose to live on purpose.
We all have a genius. We all have a hero inside all of us. It’s our mission to activate it and live it fully. That, my friends, would be sucking out the marrow of life, knowing that when I came to die that I had truly lived and not just merely existed.
And, yes, that was an allusion t...2015-08-0710 min