Shows
Where Finance Finds Its FutureWhat do stock exchanges need to survive the tokenisation of everything?The major traditional exchanges have adapted well to the migration of transactional activity to other trading platforms, notably by developing their data and post-trade revenues, so it is surprising that they remain indifferent to tokenisation. With some notable exceptions, traditional stock exchanges have shown little interest in the revolutionary potential of issuing, trading and servicing tokens. Explanations for this indifference vary. Some say the existing markets (especially equity trading) are already so efficient that tokenisation is unnecessary. The fact that exchanges which have invested in tokenisation have yet to earn a return, and are now making economies, is not...2024-08-071h 10
Bodyholic with Di | Your Health and Fitness Beyond MythsEpisode 12 Longevity and Paul Long's New Way ForwardText DiPaul Long describes New Way Forward as Paul Long’s life version 4.0. V.1 Youth and third generation storyteller. Grew up in the news business (father & grandfather). V.2 Award-winning major market television news reporter, anchor, weatherman and special projects producer. V.3 Emmy award winning Content Creator for www.paullongproductions.com. Created and produced just about every kind of film and video (short...2023-02-281h 05
Franchise UNIVERSUM - Der Podcast für SystemzentralenErfahrungsaustausch 27.4. Teil 2: Benedikt Waldner ermuntert zum Klageweg, um Behörden Druck zu machenBenedikt Waldner von EMS-Lounge berichtet über seine Erfahrungen mit Betriebsöffnungen und Behördenentscheidungen. Sie haben bundesweit verteilt Standorte. Z.B. in Baden-Würtemberg ist Personal Training gestattet. Manche Filialen haben geöffnet, wieder andere - auch in Baden-Würtemberg - durften nicht öffnen. Die Bayern fahren eine besonders harte Linie und lassen überhaupt nicht mit sich reden. Behörden lassen sich nach seiner Erfahrung nicht umstimmen.
Seine Empfehlung ist - und das wünscht er sich von möglichst vielen Systemzentralen - Klage einzureichen und die harte Linie zu fahren. Eine Flut an Klagen erhöht den Druck, so dass sich Be...2020-04-3011 min
CHI PodcastsDiscovery On Target 2014 | Opportunities and Challenges with Developing Small Molecule InhibitorsKip Harry, Conference Director at Cambridge Healthtech Institute discusses Ubiquitin Proteasome System drug discovery with Dr. Benedikt Kessler, Ph.D., University Research Lecturer, Ubiquitin Proteolysis Group, Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Discussion Questions Include:
• What are the most present opportunities in this space? (Another way to ask that): What are some of the most promising UPS targets currently being investigated, and within which indications?
• What challenges have slowed the progress of generating lead molecules targeting various components of the UPS?
• Why are Deubiquitinases (DUBs) emerging as viable therapeutic targets?
• Are there drug discovery challenges specific to targe...2014-06-0212 min
Translational MedicineProteomics and BiomarkersDr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination. Alterations in this process are responsible for many human diseases. Dr Benedikt Kessler studies the role of deubiquitylating enzymes that remove ubiquitin from substrate proteins.2011-06-0708 minTranslational and ClinicalProteomics and BiomarkersDr Benedikt Kessler tells us how proteomics helps find biomarkers. Biomarkers are molecular features that give us clues about underlying biological processes. They are typically used to monitoring a disease or predicting the outcome of a treatment. Modern analytical equipment allows us to measure thousands of molecules at the same time. Dr Benedikt Kessler studies the role of deubiquitylating enzymes, involved in the elimination of proteins marked by the ubiquitin-proteasome system. Alterations in this process are responsible for many human diseases. Dr Kessler works to improve medical diagnosis and treatment through the use of biomarkers.2011-06-0708 minTranslational MedicineProteomics and BiomarkersDr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination. Alterations in this process are responsible for many human diseases. Dr Benedikt Kessler studies the role of deubiquitylating enzymes that remove ubiquitin from substrate proteins.2011-06-0700 minTranslational and ClinicalProteomics and BiomarkersDr Benedikt Kessler tells us how proteomics helps find biomarkers. Biomarkers are molecular features that give us clues about underlying biological processes. They are typically used to monitoring a disease or predicting the outcome of a treatment. Modern analytical equipment allows us to measure thousands of molecules at the same time. Dr Benedikt Kessler studies the role of deubiquitylating enzymes, involved in the elimination of proteins marked by the ubiquitin-proteasome system. Alterations in this process are responsible for many human diseases. Dr Kessler works to improve medical diagnosis and treatment through the use of biomarkers.2011-06-0700 minTranslational MedicineProteomics and BiomarkersDr Benedikt Kessler tells us how proteomics helps find biomarkers. In most living organisms, the ubiquitin-proteasome system is responsible for the degradation of proteins, either because they're damaged or they reach the end of their life span. Ubiquitin marks a protein for elimination. Alterations in this process are responsible for many human diseases. Dr Benedikt Kessler studies the role of deubiquitylating enzymes that remove ubiquitin from substrate proteins.2011-06-0708 min