Shows
JCO Precision Oncology ConversationsAreas of Uncertainty in Pancreatic Cancer SurveillanceJCO PO author Dr. Bryson Katona at the University of Pennsylvania Perelman School of Medicine shares insights into his article, "Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium" Host Dr. Rafeh Naqash and Dr. Katona discuss how, given differing guidelines as well as lack of detail about how PC surveillance should be performed, approaches to PC surveillance across centers often differs. TRANSCRIPT Naqash: Hello and welcome to JCO Precision Oncology Conversations, where we bring you engaging conversations with authors of clinically relevant and highly significant...
2025-10-1116 min
CGA-IGC Podcast SeriesCDH1 Chats: Digesting Tough ConversationsThis episode is hosted by Josie Baker, MS, LGC, and features Maegan Roberts, MS, LGC, a Genetic Counselor from the Ohio State University.The in-depth discussions focus on CDH1 and hereditary diffuse gastric cancer, covering the history of discovery, evolving penetrance estimates, and updated risk insights. They explore differences between IGCLC’s more conservative European approach and NCCN’s U.S.-focused guidelines, offering practical advice on which to follow. The conversation highlights the challenges of genetic counseling, including how to approach discussions with honesty and confidence. Megan Roberts also shares her perspective from her work with the...
2025-08-2811 minCGA-IGC Podcast SeriesNavigating Gynecologic Cancer Risk in Lynch Syndrome: A Closer Look at Evolving GuidelinesThis episode is hosted by Emma Keel, MS, CGC, and features Ying Liu, MD, MPH, a Gynecologic Medical Oncologist & Clinical Geneticist, Memorial Sloan Kettering Cancer Center, and Nicole D. Edison, MD, Clinical Associate of Obstetrics & Gynecology, University of Chicago.The in-depth discussion focuses on managing gynecologic cancer risk in patients with Lynch syndrome, spotlighting the significant updates to the National Comprehensive Cancer Network (NCCN) guidelines released in September 2024 that have shifted the clinical approach for these patients.
2025-06-1227 minCGA-IGC Podcast SeriesEpisode 3: Research Collaboration Podcast Series - International Replication Repair Deficiency ConsortiumIn partnership, the CGA-IGC Education and Research Committees are pleased to present a three-part podcast series focused on research collaborations. Emma Keel, MS, CCG spoke with Melyssa Aronson, MSc, CGC and Lucie Stengs, BSc, from the International Replication Repair Deficiency Consortium (IRRDC). This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes research. Learn about this consortium's evolution from a local registry to an international collaboration studying rare genetic disorders, particularly CMMRD. It provides insights about the progress in developing diagnostic tools, establishing a biobank, and conducting r...
2025-05-1942 min
CGA-IGC Podcast SeriesEpisode 2: Research Collaboration Podcast Series - Gastric CDH1 Multicenter consortiumIn partnership, the CGA-IGC Education and Research Committees are pleased to present the second episode of a three-part series focused on Research Collaborations. This episode is hosted by Emma Keel, MS, CCG, who spoke with Ophir Gilad, MD, the lead of the Gastric CDH1 Multicenter Consortium.This episode is essential listening for clinicians, researchers, and anyone interested in hereditary cancer syndromes. It showcases the power of collaboration and the potential for building successful research consortiums to advance our understanding of complex genetic conditions like CDH1-related gastric cancer.
2025-04-2923 minCGA-IGC Podcast SeriesResearch Collaboration Podcast Series - LINEAGE consortium.In partnership, the CGA-IGC Education and Research Committees are pleased to present the first episode of a three-part series focused on Research Collaborations. This episode is hosted by Joshua Melson, MD, and features CGA-IGC past president Swati Patel, MD, MS, along with recipients of the CGA-IGC & CCARE Lynch Syndrome Research Award and CGA-IGC committee members, Holli Loomans-Kropp, PhD, MPH and Zachariah H. Foda, MD, PhD, all of whom are part of the LINEAGE consortium. This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes, as well as the future of...
2025-03-2232 minCGA-IGC Podcast SeriesEpisode 5 - Season 7: Síndrome de Lynch, vía acelerada del «Big Bang» y riesgo de cáncerEste episodio está copresentado por Joshua Sommovilla, MD, y Thomas (T.J.) Slavin, MD, FACMGG, DABCC, y cuenta con la participación de Pål Møller, MD, PhD, científico principal del Hospital Universitario de Oslo (Noruega).Juntos profundizan en el artículo del Dr. Møller «Incidencias de adenomas colorrectales y cánceres bajo vigilancia colonoscópica sugieren una vía acelerada “Big Bang” hacia el CCR en tres de los cuatro Síndromes de Lynch» (in English).Lea la entrada de nuestro blog (in English) para saber más sobre este podcast AQUÍ
2025-02-1434 minCGA-IGC Podcast SeriesEpisode 5 - Season 7: Lynch syndrome, the accelerated “Big Bang” pathway and cancer riskThis episode is co-hosted by Joshua Sommovilla, MD and Thomas (T.J.) Slavin, MD, FACMGG, DABCC and features Pål Møller, MD, PhD, a Senior Scientist at the Oslo University Hospital, NorwayTogether they delve into the Dr Møller's paper "Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch Syndromes."Read our blog post to learn more about this podcast HERE
2024-12-2630 minCGA-IGC Podcast SeriesSeason 7: Acceso a la atención genética en comunidades diversas: La experiencia latinoamericana (Versión española)En colaboración con LA-GETH, este podcast, en el que participan Karin Álvarez Valenzuela, PhD, de Chile, y Adriana Della Valle, MD, de Uruguay. El podcast titulado "Acceso a la Atención Genética en Comunidades Diversas: La Experiencia Latinoamericana" explora los desafíos únicos y perspectivas relacionadas con el acceso a las pruebas genéticas en poblaciones diversas de América Latina. Los expertos discuten la importancia de enfoques adaptados culturalmente para las pruebas genéticas y el potencial para abordar las disparidades en el sistema de salud. Además, este podcast destaca la investigación en curso y l...
2024-10-1426 minCGA-IGC Podcast SeriesSeason 7: Access to Genetic Care in Diverse Communities: The Latin American Experience (English version)In collaboration with LA-GETH, this podcast titled " Access to Genetic Care in Diverse Communities: The Latin American Experience" features Karin Álvarez Valenzuela, PhD from Chile, and Adriana Della Valle, MD, from Uruguay, and explores the unique challenges and insights surrounding genetic testing in diverse Latin American populations. Experts discuss the importance of culturally tailored approaches to genetic testing and the potential for addressing health disparities. Furthermore, this podcast also highlights ongoing research and the need for inclusive data to better serve diverse populations in Latin America.
2024-10-1428 minCGA-IGC Podcast SeriesEpisode 2: Previous CGA-IGC Grant recipients - Giovana Torrezan, PhDThis new podcast series, initiated by the CGA-IGC Research Committee in 2023, highlights the work of previous CGA-IGC Research Grant recipients. The second episode is hosted by Catie Neumann, MS., LCGC, a Cancer Genetic Counselor at Fox Chase Cancer Center, and features the 2022 grant recipient, Giovana Torrezan, PhD, an associate researcher at A.C. Camargo Cancer Center in Sao Paulo, Brazil.The podcast transcript is available here.
2024-08-0614 minCGA-IGC Podcast SeriesSeason 7: Mentorship - A Shared ExperienceThis episode is hosted by Veroushka Ballester, MD, MS, and features Elena M. Stoffel, MD, MPH, and Jennifer K. Maratt, MD, MS, both gastroenterologists.Together, Drs Stoffel and Maratt reflect on their mentoring connection. They delve into the significance of effective communication, mentorship planning, and vision. Their discussions also explore the dynamics of successful long-distance mentorship relationships. Tune in to gain valuable insights and practical advice!
2024-07-0525 minCGA-IGC Podcast SeriesSeason 7 - Episode 2: Decisional regret post-prophylactic gastrectomy for Hereditary Diffuse Gastric Cancer (HDGC)This episode is hosted by Josie Baker, MS, LGC, and features Jeremy Davis, MD, a National Cancer Institute (NIH) surgical oncologist.Together, they discuss Dr. Davis’ recent article published in the Journal of Medical Genetics titled “Decision-making and regret in patients with germline CDH1 variants undergoing prophylactic total gastrectomy.”This podcast was released during Patient Experience Week. Read our blog post to learn more about this podcast HERE
2024-05-0108 minCGA-IGC Podcast SeriesSeason 7 - Episode 1: Constitutional MLH1 hypermethylationThis episode is hosted by Emma Keel, MS, CGC, and features Megan Hoenig, MS, MPH, CGC a certified genetic counselor at the Mayo Clinic. Together, they discuss the contribution of MLH1 constitutional methylation to Lynch syndrome diagnosis. They also explore disease definitions and mechanisms and current genetic testing guidelines while discussing the open questions in the field. This podcast was released on #LynchSyndromeAwarenessDay. Read our blog post "MLH1 hypermethylation during #LynchSyndromeAwarenessDay" here https://tinyurl.com/3zkurynf
2024-03-2210 minCGA-IGC Podcast SeriesEpisode 5: S.6 Ep.5 Position statement of the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) on APC I1307K and Cancer RiskThis episode is hosted by Thomas Slavin, MD, FACMG, DABMD, a Chief Scientific Officer at HALO Precision Diagnostics and features Laura Valle, PhD, a Principal Investigator, at the Catalan Institute of Oncology, IDIBELL. They discuss the position statement on the APC I1307K allele and its association with cancer predisposition which was generated by a multidisciplinary international expert group endorsed by the International Society for Gastrointestinal Hereditary Tumours (InSiGHT). Read our blog post "Evidence based guidance for APC I1307K and Cancer Risk" hereStay tuned for more podcasts in 2024! If you m...
2023-12-0417 minCGA-IGC Podcast SeriesEpisode 4: S.6 Ep.4 Fight CRC Advocate Danielle Ripley-Burgess: "Life After Total Proctocolectomy in Lynch Syndrome”This episode is hosted by Thomas Slavin, MD, FACMG, DABMD, a Chief Scientific Officer, and Emma Keel, MS, CGC, a genetic counselor, who have the privilege of speaking with Danielle Ripley-Burgess as she shares her story and experience on "Life After Total Proctocolectomy in Lynch Syndrome.”We're incredibly grateful that she took the time to share her story with us, and we hope it will give our members and the broader #HereditaryGICancer community greater insight into the patient's perspective.
2023-11-0623 minCGA-IGC Podcast SeriesEpisode 3: S.6 Ep.3 Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research RegistryThis episode is hosted by Julie Yang, MD, a gastroenterologist at the Icann School of Medicine at Mount Sinai, New York, USA and features Toni T. Seppälä, M.D., PhD, a GI surgeon and Professor of Cancer Research at Tampere University, Helsinki, Finland. They discuss the results from a retrospective analysis published this year, “Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry," which can be found here. Read our blog post "Insights gained from the largest cohort of patients with pancr...
2023-10-1317 minCGA-IGC Podcast SeriesEpisode 2: S.6 Ep.2 Considerations for individuals with Hereditary Diffuse Gastric Cancer Syndrome when considering a prophylactic gastrectomyThis episode is hosted by Josie Baker, MS, CGC, a genetic counselor at The Ohio State University, and features Rachael Lopez, MPH, RD, CSO, a clinical research dietitian at the National Institutes of Health. Together they discuss the considerations for individuals with Hereditary Diffuse Gastric Cancer Syndrome when considering a prophylactic gastrectomy. This episode highlights the professional experience when working with these individuals before and after surgery, as well as the challenges individuals may face during this process.
2023-06-2020 minCGA-IGC Podcast SeriesPrevious CGA-IGC Grant recipients - Dr. Allison Burton-ChaseThe CGA-IGC Research Committee will host a new podcast series highlighting the work of the CGA-IGC Research Grant recipients. The first episode will feature the 2014 grant recipient, Dr. Allison Burton-Chase, and explore her research into Lynch syndrome patient-provider relationships, communication, and transition.The papers in the order they were referenced:
Hennig K, DeCoster B, Chu R, Parker W, Campo-Engelstein L, Burton-Chase AM. Patients educating health care providers on Lynch syndrome. Patient Experience Journal. 2018; 5(3):91-96. doi: 10.35680/ 2372-0247.1319. https://pxjournal.org/cgi/viewcontent.cgi?article=1319&context=journal
Burton-Chase AM, Parker WM, Hennig K, Sisson F, Bruzzone LL. T...
2023-05-3123 minCGA-IGC Podcast SeriesEpisode 1: S.6 Ep.1 Cancer Prevention with Resistant Starch in Lynch (CAPP2 Trial)This episode is hosted by Swati G. Patel, M.D., MS and features Sir John Burn, M.D., MBBS, BMedSci, a professor of Clinical Genetics at Newcastle University and senior leader in England's National Health Service. Together they discuss the 10 year follow-up results of the seminal Cancer Prevention Programme (CAPP2) trial described in the Cancer Prevention Research article titled “Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo-Controlled Trial: Planned 10-Year Follow-up” which can be found here. Read our blog post Does starch prevent cancer in patients with lynch syndrome by a mec...
2023-03-2230 minCGA-IGC Podcast SeriesS.5 Ep.8 PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal CancerThis episode is hosted by Matt Yurgelun, M.D, a GI medical oncologist at the Dana-Farber Cancer Institute in Boston, MA, and features a discussion between Zsofia Stadler, M.D, a GI medical oncologist at the Memorial Sloan Kettering Cancer Center, New York, NY and Andrea Cercek, M.D, a GI medical oncologist also at the Memorial Sloan Kettering Cancer Center, New York, NY.Together they discuss "PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer" which was published in the New England Journal of Medicine and found here https://pubmed.ncbi.nlm.nih.gov/35660797/
2022-11-2921 minCGA-IGC Podcast SeriesS.5 Ep.7 Evidence for Gastric Cancer Surveillance in Lynch SyndromeThis episode is hosted by Pooja Dharwadkar, M.D, assistant professor at the University of California San Francisco, and features a discussion between Carol Burke, M.D, codirector of the Hereditary Cancer Clinic at the Cleveland Clinic; Robert Hüneburg, M.D, gastroenterologist at the National Center for Hereditary Tumor Syndromes at University Hospital Bonn in Bonn, Germany; and Bryson Katona, M.D, director of the GI Cancer Genetics and Cancer Risk Evaluation programs at the Hospital of the University of Pennsylvania in Philadelphia, PA. They discuss the benefits of upper GI cancer surveillance in Lynch syndrome – specifically as it...
2022-10-2025 minCGA-IGC Podcast SeriesS.5 Ep.6 Is it Time for Universal Germline Genetic Testing for All GI Cancers? A podcast debate!On the occasion of the 2022 #PrevivorDay and #HereditaryCancerWeek, we're delighted to bring you a podcast debate as part of the CGA-IGC 2022 Podcast Series - Episode 6.This episode is hosted by Michael J. Hall, MD, MS, Fox Chase Cancer Centre and features Heather Hampel, MS, CGC, City of Hope and Matthew B. Yurgelun, MD, Dana-Farber Cancer Institute.The debate features Professor Heather Hampel and Dr Matthew Yurgelun going head to head over "Is it Time for Universal Germline Genetic Testing for All GI Cancers?", which was published in the Journal of Clinical O...
2022-09-2837 min
Wellness Wednesday with Rolfe Pancreatic Cancer FoundationKnow Your Risk: Hereditary Syndromes & Pancreatic Cancer with Dena Goldberg, MS, Licensed Certified Genetic CounselorFor more information about Rolfe, Wellness Wednesday or Dena Goldberg visit: https://tinyurl.com/WWednes
Pancreatic cancer is a genetic disease caused by changes, or mutations, in our DNA. These changes can be inherited (we’re born with them) or acquired (develop after birth), explaining why pancreatic cancer runs in some families. In fact, those with a family history are more likely to have an inherited gene mutation that increases their risk for pancreatic cancer. So how do we best educate and protect ourselves about our genetic risks?
Join us as we welc...
2022-08-251h 24CGA-IGC Podcast SeriesS.5 Ep.5 The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and SurvivalThis episode is hosted by Beth Dudley, MS, MPH, CGC, University of Pittsburgh Medical Center and features Michael G. Goggins, M.B.B.CH., M.D., The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions.Together they discuss “The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival” which was published in the Journal of Clinical Oncology and found here: https://pubmed.ncbi.nlm.nih.gov/35704792/This episode was recorded on June 21st, 2022 and reflects expert opinion at the time of the recording.
2022-08-1629 minCGA-IGC Podcast SeriesS.5 Ep.4 Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch SyndromeThis episode is hosted by Joshua Sommovilla, M.D, The Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia at the Cleveland Clinic and features Matthew Kalady, M.D, The Ohio State University Wexner Medical Center and Mohammad Abbas, M.D., MPH, Northwestern University.Together they discuss “Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch Syndrome” which was published in the Journal of Dis Colon Rectum. and found here: https://pubmed.ncbi.nlm.nih.gov/34882627/This episode was recorded on April 25th, 2022 and reflects expert opinion at the time...
2022-07-1812 minCGA-IGC Podcast SeriesS.5 Ep.3 Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the CGA-IGCThis episode is hosted by Thomas (T.J.) Slavin, M.D.,FACMGG, PhD and features Rachel Hodan, MS, CGC, Genetic Counselor & Clinical Assistant Professor at Stanford University, Cancer Genetics Clinic and Kimberly Perez, MD, Gastrointestinal Medical Oncologist & Assistant Professor of Medicine, Dana Farber Cancer Institute.Together they discuss “Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the CGA-IGC” which was published in the Journal of Genetic Counseling and found here: https://pubmed.ncbi.nlm.nih.gov/35218578/The CGA Clinical Practice Survey 2022: Unive...
2022-06-2010 minCGA-IGC Podcast SeriesS.5 Ep.2 EUS - based Pancreatic Cancer Surveillance in BRCA1/BRCA2/PALB2/ATM Carriers without a Family History of Pancreatic CancerThis episode is hosted by Thomas (T.J.) Slavin, M.D.,FACMGG, PhD and features Bryson Katona, M.D., PhD, Director, Gastrointestinal Cancer Genetics Program & Assistant Professor of Medicine at the Hospital of the University of Pennsylvania; and Jessica Long, MS, CGC, Division of Hematology–Oncology, Department of Medicine at the University of Pennsylvania. Together they discuss the article “EUS-based Pancreatic Cancer Surveillance in BRCA1/BRCA2/PALB2/ATM Carriers Without a Family History of Pancreatic Cancer” which was published in Cancer Prevention Research and found here: https://pubmed.ncbi.nlm.nih.gov/34341011/ Studies mentioned during the podcast...
2022-05-1820 min
CGA-IGC Podcast SeriesS.5 Ep.1 Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA MutationsThis episode is hosted by Maureen May, MS, CGC and features Bronwyn Bedrick, M.D., M.S.C.I., who is a Gynecology and Obstetrics Resident Physician at Johns Hopkins Hospital. Together they discuss the article “Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA Mutations,” which was published in Obstetrics & Gynecology and found here: https://pubmed.ncbi.nlm.nih.gov/34735408/Resources mentioned during the podcast
WPATH Standards of Care (free to download in many different languages): Standards of Care - WPATH World Professional Association for Transgender Health (https://wpath.org/publications/soc)
WPATH Provid...
2022-03-2420 min
Bowel Sounds: The Pediatric GI PodcastSteven Erdman - Polyps and Polyposis Syndromes in ChildrenIn this episode of Bowel Sounds, hosts Dr. Peter Lu and Dr. Jennifer Lee talk to Dr. Steven Erdman about polyps and hereditary polyposis syndromes in children. Dr. Erdman is a pediatric gastroenterologist at Nationwide Children's Hospital, Professor of Pediatrics at The Ohio State University College of Medicine, and past president of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC). We talk to him about all things related to polyps in children, starting from the humble solitary juvenile polyp to the various polyposis syndromes we can encounter in children, including Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (J...
2021-09-2747 min
CGA-IGC Podcast SeriesS.4 Ep.5 Impact of Patients' Companions on Clinical Encounters Between Black Patients and Their Non-Black OncologistsThis episode is hosted by Dr. Thomas Slavin (T.J.) and features Amy K. Otto, PhD, who is a Research Assistant Professor in the Department of Public Health Sciences at the University of Miami Miller School of Medicine. Together they discuss the article “Impact of Patients' Companions on Clinical Encounters Between Black Patients and Their Non-Black Oncologists,” which was published in JCO Oncology Practice and found here: https://pubmed.ncbi.nlm.nih.gov/33411574/ This episode was recorded on August 26, 2021 and reflects expert opinion at the time of the recording.
2021-09-1413 minCGA-IGC Podcast SeriesS.4 Ep.4 Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention InitiativeThis episode is hosted by Dr. Thomas Slavin (T.J.) and features Rachel Pearlman, MS, CGC, who is a Licensed, Certified Genetic Counselor and Assistant Professor in the Department of Internal Medicine at The Ohio State University Comprehensive Cancer Center. Together they discuss the article “Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative,” which was published in JCO Precision Oncology and found here: https://pubmed.ncbi.nlm.nih.gov/34250417/This episode was recorded on August 10, 2021 and reflects expert opinion at the time of the recording.
2021-08-1611 min
Wellness Wednesday with Rolfe Pancreatic Cancer FoundationGenetic Counseling vs. Genetic Testing with Dena Goldberg, CGCEverywhere we turn, we are bombarded by messages to uncover our family’s history or genetic code. Finding out your lineage and potential hereditary conditions seems as easy as typing a few strokes on a keypad. And while it may be fun to discover that your great-grandmother was a trailblazer, not all information is as it appears. It’s important to understand what the at-home genetics tests are really telling you, and more importantly, what are they missing?
Join us as we welcome back Dena Goldberg, Genetic Counselor and Founder of DenaDNA as she shares:
- Th...
2021-07-2256 minCGA-IGC Podcast SeriesS.4 Ep. 3 Naproxen Chemoprevention Promotes Immune Activation in Lynch Syndrome Colorectal MucosaThis episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Eduardo Vilar-Sanchez. Dr. Vilar-Sanchez is a medical oncologist at MD Anderson Cancer Center. Together they discuss “Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa,” which was published in Gut and found here: https://pubmed.ncbi.nlm.nih.gov/32641470/This episode was recorded on March 26, 2021 and reflects expert opinion at the time of the recording.
2021-04-1213 minCGA-IGC Podcast SeriesS.4 Ep. 2 Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A VariantThis episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Bryson Katona and Dr. Suzanne MacFarland. Dr. Katona is a gastroenterologist at Penn Medicine and Dr. MacFarland is an oncologist in the Children’s Hospital of Philadelphia. Together they discuss their recent publication, “Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant,” published in Cancer Prevention Research and found here: https://pubmed.ncbi.nlm.nih.gov/33097490/ This episode was recorded on January 25, 2021 and reflects expert opinion at the time of the recording.
2021-03-1715 minCGA-IGC Podcast SeriesS.4 Ep. 1 Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous PolyposisThis episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Carol Burke, a gastroenterologist at the Cleveland Clinic. They discuss a study of combination therapy to delay disease progression in patients with familial adenomatous polyposis, recently published in The New England Journal of Medicine, found here: https://pubmed.ncbi.nlm.nih.gov/32905675/This episode was recorded on January 12, 2021 and reflects expert opinion at the time of the recording.
2021-02-1614 minCGA-IGC Podcast SeriesS.3 Ep.6 Hereditary diffuse gastric cancer: updated clinical practice guidelinesThe sixth episode, hosted by Dr. TJ Slavin, features Dr. Sonia Kupfer, a gastroenterologist at University of Chicago and former CGA-IGC president. They discuss the updated clinical practice guidelines for hereditary diffuse gastric cancer that were recently published online in Lancet Oncology, found here: https://pubmed.ncbi.nlm.nih.gov/32758476/ . This episode was recorded on September 21, 2020, and reflects expert opinion at the time of the recording.
2020-10-2111 minCGA-IGC Podcast SeriesS.3 Ep. 5 Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trialThe fifth episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Sir John Burn, who is a professor of clinical genetics at Newcastle University, and Dr. Toni Seppälä, who is a GI surgeon from University of Helsinki currently conducting a research fellowship at Johns Hopkins University. They discuss recently updated data from the CAPP2 study of aspirin chemoprevention in individuals with Lynch syndrome that was published in Lancet this summer, found here: https://pubmed.ncbi.nlm.nih.gov/32534647/. This episode was recorded on September 22, 2020, and reflects expert opinion at the time of the recording.
2020-10-1928 minCGA-IGC Podcast SeriesS.3 Ep. 4 Highlights from the 2020 ASCO Annual MeetingThis episode is hosted by Dr. Leah Biller and features Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan Kettering Cancer Center and CGA council member, and Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center and CGA past president. They discuss data from Abstract 1500 (https://meetinglibrary.asco.org/record/185963/abstract), which reports on targeted therapy based on germline analysis of tumor-normal sequencing in a pan-cancer population, as well as data from the plenary presentation about the clinical trial KEYNOTE-177 (https://meetinglibrary.asco.org/record/186928/abstract), a study of pembrolizumab versus standard therapy for treatment of MSI-H metastatic...
2020-09-1428 minCGA-IGC Podcast SeriesS.3 Ep.3: Updates in the Evaluation and Management of Serrated Polyposis Syndrome (SPS)The third episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Dr. Arne Bleijenberg, who is a research fellow at Amsterdam University Medical Center, and Dr. Evelien Dekker, who is a professor in the Department of Gastroenterology & Hepatology and Gastrointestinal Oncology and the head of the Hereditary Cancer Center at the Amsterdam University Medical Center. They discuss the recently updated World Health Organization Guidelines on diagnosis of Serrated Polyposis Syndrome (SPS) (summarized here https://pubmed.ncbi.nlm.nih.gov/31982410/). Dr. Bleijenberg and Dr. Dekker also discuss their recent publications that shed light on a personalized approach to surveillance in...
2020-07-1330 minCGA-IGC Podcast SeriesS.3 Ep.2: A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer SurvivorsThe second episode features Dr. Leah Biller, CGA education committee member, who is interviewed by fellow CGA education committee member TJ Slavin. They discuss "A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors", recently published online in Cancer Prevention Research. You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32051178This episode was recorded May 5, 2020 and reflects expert opinion at the time of the recording.
2020-05-1809 minCGA-IGC Podcast SeriesS3. Ep.1: Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposisEach episode of the 2020 season of the CGA-IGC podcast series will be a short journal club featuring a recently published article of interest to our membership.The first episode features Brandie Heald Leach, former CGA president, who is interviewed by CGA education committee member TJ Slavin. They discuss the CGA-IGC position statement on multi-gene panel testing for hereditary colorectal cancer and polyposis, published online in Familial Cancer on March 14, 2020.You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32172433This episode was recorded April 8, 2020 and reflects expert opinion at the time...
2020-04-1309 minCGA-IGC Podcast SeriesS2 Ep.6: Transitioning from Pediatric to Adult Care for Patients with FAPThe 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately. The sixth and final episode features Kristin Zajo, a genetic counselor at Nationwide Children’s Hospital in Columbus Ohio. In this episode, we focus on children and young adults with FA...
2019-12-1923 minCGA-IGC Podcast SeriesS2. Ep.5: Thyroid disease in FAPThe 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.The fifth episode features Dr. Jennifer Sipos, an endocrinologist at the Ohio State University. In this episode, she reviews the epidemiology, surveillance, and management of thyroid disease in FAP.
2019-10-2330 minCGA-IGC Podcast SeriesS2 Ep.4: Desmoid disease in FAPThe 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.The fourth episode features Dr. James Church, colorectal surgeon, and Dr. Dale Shepard, medical oncologist, both of the Cleveland Clinic. In this episode, they discuss the biology, medical and surgical...
2019-09-0929 minCGA-IGC Podcast SeriesS2 Ep.3: Management of Duodenal Neoplasia in FAPThe 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately. The third episode features Dr. Jewel Samadder, gastroenterologist and advanced endoscopist at the Mayo Clinic in Phoenix, Arizona. Dr. Samadder has a specific focus on hereditary cancer conditions, with distinct...
2019-08-0624 minCGA-IGC Podcast SeriesS2 Ep.2: Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of APC-Associated conditions.In the second episode, Dr. Daniel Worthley, an expert in hereditary cancer syndromes from the South Australian Health and Medical Research Institute, tells the tale of how Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) was first recognized and characterized. GAPPS is caused by a mutation in the promotor region of the APC gene and is inherited in an autosomal dominant fashion. This condition is associated with a significantly increased risk of gastric...
2019-05-2815 minCGA-IGC Podcast SeriesS2 Ep.1: Gastric Polyps and Cancer in FAPThe 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately. In the first episode, Dr. Dennis Ahnen interviews Drs. Carol Burke and Gautam Mankaney, who are both gastroenterologists in the Cleveland Clinic Hereditary Cancer Clinic. They discuss the types of...
2019-04-2930 minCGA-IGC Podcast SeriesS1 Ep.5: Breast Cancer and LynchHow to counsel patients about the link between Breast Cancer and Lynch Syndrome featuring Dr. Nadine TungIn this episode, Dr. Katherine A. Germansky interviews Dr. Nadine Tung, Director of Breast Medical Oncology and Director of Cancer Genetics and Prevention Program at Beth Israel Deaconess Medical Center. She will be discussing the link between Lynch Syndrome and Breast Cancer.Hosted by: Katharine A. Germansky, MDGastroenterologist at Beth Israel Deaconess Medical CenterNote: This episode was recorded on 7/10/2018. The content of this podcast is not intended to be a substitute for professional...
2018-10-0422 minCGA-IGC Podcast SeriesS1 Ep.4: Urologic Risks in LynchHow to counsel patients about urologic cancer risks featuring Dr. Jodi Maranchie.In this episode, Beth Dudley interviews Dr. Jodi Maranchie, a Urologist at the University of Pittsburgh. She will be discussing how she talks to Lynch Syndrome patients about urologic cancer risks, screening options and special considerations in treatment.Hosted by: Beth Dudley, MSGenetic Counselor at University of Pittsburgh Medical CenterNote: This episode was recorded on 8/24/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice...
2018-10-0411 minCGA-IGC Podcast SeriesS1 Ep.3: Gynecologic Risks in LynchHow to counsel patients about gynecologic cancer risks and family planning option in Lynch Syndrome featuring Dr. Leslie Garrett.In this episode, Dr. Katherine A. Germansky interviews Dr. Leslie Garrett, Director of the Division of Gynecologic Oncology at Beth Israel Deaconess Medical Center. She will be discussing how she talks to Lynch Syndrome patients about family planning, gynecologic cancer risks, screening options and prophylactic surgery.Hosted by: Katharine A. Germansky, MDGastroenterologist at Beth Israel Deaconess Medical CenterNote: This episode was recorded on 8/1/2018. The content of this podcast is not intended...
2018-10-0420 minCGA-IGC Podcast SeriesS1 Ep.2: Cancer Risks in Lynch Part IIHow to counsel patients about cancer risks in Lynch Syndrome featuring Dr. Sonia Kupfer: Part IIIn this episode, Dr. Swati G. Patel continues the conversation with Dr. Sonia Kupfer, Director of the Gastrointestinal Cancer Risk and Prevention Center at the University of Chicago. She will be discussing extra-intestinal cancer risks in Lynch Syndrome and strategies to minimize risk including screening and chemoprevention. Hosted by: Swati G. Patel, MD, MS Gastroenterologist at University of Colorado and Director of GI Cancer Risk and Prevention CenterNote: This episode was recorded on 3/14/2018. The content...
2018-10-0427 minCGA-IGC Podcast SeriesS1 Ep.1: Cancer Risks in Lynch Part IHow to counsel patients about cancer risks in Lynch Syndrome featuring Dr. Sonia Kupfer: Part IIn the first episode, Dr. Swati G. Patel interviews Dr. Sonia Kupfer, Director of the Gastrointestinal Cancer Risk and Prevention Center at the University of Chicago. She will be discussing how she explains cancer risks to her Lynch Syndrome Patients. She will review her general approach to the discussion and review recommendations for decreasing risk of digestive cancers.Hosted by:Swati G. Patel, MD, MSGastroenterologist at University of Colorado and Director of GI Cancer Risk and Prevention...
2018-10-0426 min