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(www.gosountrack.com)2015-05-0702 min
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 05/06The backbone of prokaryotic adaptive immunityCRISPR/Cas is the prokaryotic adaptive immune response to viral invasion. Its mechanism is reminiscent of the eukaryotic RNA interference. The host actively incorporates short sequences from invading genetic elements (viruses or plasmids) into a region of its genome that is characterized by clustered regularly interspaced short palindromic repeats (CRISPRs) and a number of CRISPR-associated (cas) genes. The molecular memory of previous infections can be transcribed and processed into small RNAs (crRNAs) that guide a multiprotein–nucleic acid interference complex to recognize and cleave incoming foreign genetic material. Three pathways (I, II, III) are defined by their protein machinery and ta...2014-10-3000 min