Shows
Restart Creative PodCatarina Cunha: o Porto Canal, a importância da saúde mental e o ballet contemporâneoNa universidade, Catarina Cunha estudou comunicação, mas sentiu cedo que precisava de um contacto mais prático com a realidade do jornalismo.
Foi na Restart, através do curso de Apresentador de TV e Rádio que encontrou um lugar diferente para a sua profissão e que conheceu formadores marcantes.
Neste momento, Catarina está dedicada à intensa tarefa diária do jornalismo digital no Porto Canal. Neste episódio, partilha com Vanessa Augusto que imagina, para si, um lugar na comunicação que passe por desmistificar e esclarecer a doença mental, bem como apostar num pr...2024-03-0930 min
Science SocietyWeekly recap and science news: AI inventing own culture?We have a summary of speaker events and science news updates! Join us!!2022-06-063h 26Science SocietyBattling the Bee Parasite: Advances with Dr. Thomas A. O'Shea-WhellerThe survival of honey bee colonies worldwide is threatened by the ectoparasite Varroa destructor. In this riveting episode, we host Dr. Thomas A. O’Shea-Wheller, who has dedicated his research to uncovering solutions to this pressing issue.O'Shea-Wheller presents an in-depth study of a Varroa-resistant honey bee stock, known as 'Pol-line', and its potential in tackling this parasite threat. The study, conducted on a large scale and over an extended period, showed promising results. The 'Pol-line' demonstrated significantly reduced Varroa levels, lower titres of three major viruses vectored by the mite (DWV-A, DWV-B, and CBPV), and a no...2022-05-281h 42Science SocietyThe Mysteries of Interstellar PAHs: A Deep Dive with Dr. McGuireIn this captivating episode, we host Dr. McGuire, whose groundbreaking work in radio astronomy offers new insights into the presence and identification of polycyclic aromatic hydrocarbons (PAHs) in space. PAHs are abundant in many astronomical objects as shown by mid-infrared spectroscopy, but the challenge of determining specific PAH molecules has been a longstanding issue in the field.Dr. McGuire and his team employed a novel approach to tackle this problem by using a stacking and matched filter analysis to scrutinize radio observations of TMC-1, a region within the interstellar Taurus Molecular Cloud. Their rigorous analysis led to...2022-05-281h 38Science SocietyUnveiling New human Lung Cell Type for Gas Exchange : A Conversation with Dr. MorriseyIn this episode, we are thrilled to have Dr. Morrisey join us as he sheds light on his groundbreaking research into the human lung's unique structure and its implications on diseases like chronic obstructive pulmonary disease (COPD).The human lung's architecture is markedly different from that of mice, particularly in its distal airway configuration and its interplay with the alveolar gas-exchange niche, resulting in a unique anatomical structure known as the respiratory bronchioles. This uniqueness has largely left the cellular and molecular mechanisms governing respiratory bronchioles unexplored, owing to the lack of a counterpart in mice. 2022-05-281h 12Science SocietyTurning Plastic Waste into CO2 Sponges: A Conversation with Dr. James TourIn this episode, we are delighted to host the renowned scientist Dr. James Tour, whose recent research offers a groundbreaking solution to two of the most urgent environmental problems we face today – plastic waste and escalating atmospheric carbon dioxide (CO2) levels.Dr. Tour's team has demonstrated that the thermal treatment of plastic waste in the presence of potassium acetate can produce an effective carbon sorbent capable of capturing CO2. Remarkably, this process works with single or mixed streams of polyolefin plastics. The resulting material possesses pores with a width of 0.7–1.4 nm, allowing for significant CO2 capture and easy...2022-05-281h 32Science SocietyUnraveling the Complex Role of Repetitive Elements in the Human Genome with Dr. O'NeillIn this illuminating episode, we welcome distinguished scientist Dr. O'Neill to discuss their critical research on repetitive elements in the human genome, their influence on our genetic variation and health, and the technological advancements facilitating this research.Repetitive elements like transposable elements (TEs), repeat expansions, and repeat-mediated structural rearrangements significantly shape chromosome structure, species evolution, and human health, contributing to our genetic variation. Despite their pivotal role, technological limitations during the human genome reference GRCh38 development have left these repetitive regions unexplored.Dr. O'Neill and team utilized long-read sequencing to support the complete assembly of...2022-05-281h 36Science SocietyA Comprehensive Recap of Our Weekly Guest Speaker Series May 16-21 2022Join us for this summary episode, where we dive into the highlights from our recent guest speaker series. Each week, we hosted exceptional thought leaders and researchers from diverse fields, who shared their pioneering research, intriguing discoveries, and insightful perspectives.Our lineup featured some of the greatest minds in fields spanning from neuroscience and genomics to environmental science and artificial intelligence. These discussions touched on everything from the intricacies of brain development and the mysteries of the human genome to groundbreaking solutions for environmental challenges and innovative advancements in AI technology.In this episode, we'll...2022-05-281h 39Science SocietyRevolutionary Methods in Machine Learning: Molecular-Orbital-Based ML with Dr. ChengIn this enlightening episode, we welcome Dr. Cheng, a leading researcher in the field of machine learning (ML). We explore the innovative approach of ML in representing molecular-orbital-based (MOB) features for predicting post-Hartree–Fock correlation energies. Though previous applications of MOB-ML using Gaussian Process Regression (GPR) have shown promise, Dr. Cheng addresses the limitations of this method, particularly its computational constraints, when dealing with large datasets.Dr. Cheng introduces us to an advanced approach, employing a clustering/regression/classification model of MOB-ML. He elaborates on the three-step process: partitioning the training data using regression clustering (RC), independently re...2022-05-222h 16Science SocietyDecoding Dogs' Perception of Human Emotion: A Conversation with Dr. GuoIn a fascinating conversation with Dr. Guo, we delve into the world of canine emotion perception and their ability to understand both human and dog emotions. Domestic dogs, unlike many other species, have uniquely evolved to recognize and interpret the emotions of not only their own species but also those of humans, their closest companions.In this episode, Dr. Guo illuminates his research by employing a cross-modal preferential-looking paradigm to study dogs' reactions to different emotional expressions. Dogs were presented with either human or dog faces displaying varying emotional states—ranging from happiness and playfulness to anger an...2022-05-221h 36Science SocietyDiving into the Intricacies of Peptide Sequence Buildup: Biological Design with Dr. UlijnIn this fascinating episode, we welcome Dr. Ulijn, a pioneering researcher in the field of peptide sequence buildup and molecular adaptation. He delves into his groundbreaking study that illuminates the behavior of living systems and their distinctive ability to distribute stress among a vast number of covalent and noncovalent interactions in mixtures of molecules.Dr. Ulijn takes us on a journey into the world of biomolecular complexity, starting from the basics. He discusses how the selection of a chemical interaction space of mixtures of 5 or 15 dipeptides, through reversible enzymatic sequence exchange, can produce 25 or 225 dynamically interacting tetrapeptides...2022-05-222h 14Science SocietyRevolutionizing Organelle Study: Mitochondria transplantation with Dr. GäbeleinIn this intriguing episode, we welcome Dr. Gäbelein, a scientist at the forefront of cell biology, as he introduces us to a revolutionary approach for manipulating organelle structures within single live cells. This technique, based on FluidFM, involves atomic force microscopy, optical microscopy, and nanofluidics to achieve precision in force and volume control and provides real-time examination capabilities.Dr. Gäbelein walks us through the process of developing this innovative technology, highlighting the role of specially designed probes that facilitate minimal invasive entry into cells. He further elaborates on how optimizing fluid flow allows for the ex...2022-05-221h 34Science SocietyEnergy, Fatigue, and the Gut Microbiome: An Exploratory Study with Dr. BoolaniIn this episode, we're thrilled to host Dr. Boolani, who delves into the intriguing scientific connections between our moods and our gut microbiome. The discussion kicks off with an exploration into how traits like energy and fatigue could be unique unipolar moods with their own mental and physical components. This sets the stage for a revealing exploration of Dr. Boolani's recent study that sought to uncover the correlations between these moods and the gut microbiome.Twenty physically active, non-obese subjects participated in the study, and the results were astonishing. The analysis revealed how different bacterial communities, primarily...2022-05-221h 53Science SocietyThe Role of Early-Life Adversity and Microglial Actions on Stress: Uncovering Mechanisms with Dr. BoltonJoin us in this enlightening episode with Dr. Bolton, who explores the fascinating relationships between early-life adversity (ELA), the maturation of stress-related brain circuits, and subsequent mental health vulnerabilities. Her recent study delves into the profound ways ELA influences brain development, specifically impacting the hypothalamic corticotropin-releasing hormone (CRH) neurons.Dr. Bolton reveals that ELA increases functional excitatory synapses onto these stress-sensitive neurons, disrupting the typical developmental synapse pruning process performed by adjacent microglia. The disrupted activity of these microglia is connected to diminished signaling of the microglial phagocytic receptor MerTK in mice exposed to ELA....2022-05-221h 33Science SocietyRevolutionizing Nuclear Fusion with Magnetic Control and Reinforcement Learning with Dr. FeliciIn this insightful episode, we're delighted to welcome Dr. Felici, an innovator pushing the boundaries of sustainable energy production through nuclear fusion. Dr. Felici introduces us to the complex world of magnetic confinement in tokamak configurations, highlighting the promise and challenges this path toward sustainable energy presents.One of the core challenges in this field is shaping and maintaining high-temperature plasma within the tokamak vessel. Dr. Felici discusses the necessity of high-dimensional, high-frequency, closed-loop control using magnetic actuator coils and the complications posed by diverse requirements across a wide range of plasma configurations.Delving into...2022-05-222h 17Science SocietyA Comprehensive Recap of Our Weekly Guest Speaker Series May 9-14 2022Join us for this summary episode, where we dive into the highlights from our recent guest speaker series. Each week, we hosted exceptional thought leaders and researchers from diverse fields, who shared their pioneering research, intriguing discoveries, and insightful perspectives.Our lineup featured some of the greatest minds in fields spanning from neuroscience and genomics to environmental science and artificial intelligence. These discussions touched on everything from the intricacies of brain development and the mysteries of the human genome to groundbreaking solutions for environmental challenges and innovative advancements in AI technology.In this episode, we'll...2022-05-2238 minScience SocietyExploring Paradoxes and Time Travel: A Thought-Provoking Discussion with Dr. ShoshanyIn this episode, we are joined by Dr. Soshany, a researcher delving into the realm of time travel and its potential paradoxes. If time travel were possible, it would seemingly lead to perplexing paradoxes, including the famous grandfather paradox and bootstrap paradoxes where creation appears to come from nothing. Dr. Soshany introduces us to his groundbreaking mathematical model for a spacetime with a time machine. He explains two intriguing multiple-histories models, which propose solutions to time travel paradoxes by allowing for multiple timelines or histories. Any changes to the past, under these models, would occur in a...2022-05-222h 26Science SocietyRedefining Sustainable Energy: Artificial Photosynthesis and Solar-to-Fuel Efficiency with Dr. SinghIn this compelling episode, we sit down with Dr. Singh to discuss the future of sustainable energy via an artificial photosynthetic (AP) system. Dr. Singh guides us through the fascinating concept of artificial photosynthesis, highlighting the challenges and opportunities of capturing CO2 directly from dilute sources such as flue gas and air to produce fuels and chemicals.Delving into the core of his research, Dr. Singh introduces us to the design and evaluation of an integrated AP system that harnesses sunlight to convert captured CO2 into fuels. His work explores the solar-to-fuel (STF) efficiency of such a...2022-05-152h 06Science SocietyAdvancements in Pancreatic Islet Transplantation and Cryopreservation: A Deep Dive with Dr. FingerIn this episode, we're privileged to host Dr. Finger, a leading figure in the field of pancreatic islet transplantation. We explore the intricacies of this potentially life-altering treatment for diabetes, which, while promising, faces significant hurdles related to the supply chain and quality control of donor islets.Dr. Finger takes us through the transformative potential of cryopreservation to solve these challenges. The key, he explains, lies in the meticulous optimization of cryoprotectant agent composition, loading and unloading conditions, and methods for vitrification and rewarming. This strategy can successfully preserve islets from a variety of sources, including mice...2022-05-141h 19Science SocietyInnovations in Polymeric Membranes for Carbon Dioxide Capture: A Conversation with Dr. SpontakIn this fascinating episode, we sit down with Dr. Spontak, an expert in polymeric membranes, to discuss the latest breakthroughs in carbon dioxide capture technology. As global climate change continues to dominate scientific and public discourse, the need for effective, low-cost, and scalable carbon capture solutions has never been greater.Dr. Spontak introduces us to a groundbreaking hybrid-integrated membrane strategy that could change the face of carbon capture. His team's innovative design overcomes the long-standing tradeoff between permeability - the speed at which gases flow through the membrane - and selectivity - the ability to separate one...2022-05-141h 30Science SocietyWeekly recap May 2-7 2022Join us for the weekly recap! Did you miss our guest speaker talks? Do you still have unanswered questions? During the weekly recap we will summarize the guest speaker rooms we had the previous week.2022-05-141h 10Science SocietyHarnessing Phase-Change Memtransistive Synapses for Neuromorphic Computing: Insights from Dr. Sarwat at IBM ResearchIn this insightful episode, we are joined by Dr. Sarwat from IBM Research, who introduces us to the groundbreaking realm of phase-change memtransistive synapses for neuromorphic computing. This new field is inspired by the biological nervous system's ability to adapt and learn, bringing transformative potential to the world of computing.Neuromorphic computing aims to recreate the functionalities of the mammalian nervous system, where multiple synaptic plasticity rules operate over wide-ranging timescales to enable learning and memory formation. Dr. Sarwat explains the challenges of achieving this in artificial synapses and how conventional methods fall short in emulating these...2022-05-072h 10Science SocietyExploring T Cell Roles in Parkinson's Disease with Dr. ArlehamnIn this enlightening episode, we are joined by Dr. Arlehamn as we delve into the complex world of Parkinson's Disease (PD), a multi-stage neurodegenerative disorder with largely unknown causes. Recently, T cells have been identified to play a significant role in the autoimmune features associated with PD.Dr. Arlehamn takes us through his team's cutting-edge research that involves RNA sequencing on PBMC and peripheral CD4 and CD8 memory T cell subsets derived from PD patients and age-matched healthy controls. When these groups were stratified by their T cell responsiveness to alpha-synuclein (α-syn), the study revealed a broad d...2022-05-071h 09Science SocietyUnderstanding Topological Nanospasers with Dr. GhimireIn this thought-provoking episode, Dr. Ghimire joins us to discuss his research on topological nanospasers, an emerging field of study with vast potential for applications in diverse areas including infrared spectroscopy, sensing, probing, and biomedical treatment.A topological nanospaser, as Dr. Ghimire explains, is a system consisting of a silver nanospheroid and a MoS2 monolayer flake with a circular shape. The metal nanospheroid functions as a plasmonic nanoresonator, supporting two rotating modes, which are coupled to the corresponding valleys of MoS2. When external circularly polarized light is applied, it selectively pumps only one of the valleys of...2022-05-071h 52Science SocietyDecoding Quantum Gravity and Classical Spacetime ‘holographic principle’ with Dr. PerssonIn this episode, we're honored to host Dr. Persson, who explores one of the most intriguing challenges in quantum physics - explaining the emergence of the classical spacetime geometry from a more fundamental, microscopic perspective.Dr. Persson guides us through the intricacies of the gauge/gravity-correspondence, a holographic framework that associates a supergravity theory in five-dimensional Anti-deSitter space with a strongly coupled superconformal gauge theory on its 4-dimensional flat Minkowski boundary. In this context, the classical geometry should manifest from a specific quantum state of the dual gauge theory.Supporting this principle, Dr. Persson presents...2022-05-071h 48Science SocietyMachine-Learning in Material Science to find new rare-earth compounds with Dr. SinghJoin us in this engaging episode with Dr. Singh, who introduces us to an exciting application of machine learning in the realm of material science. He elucidates how chemical alloying can impact the formation enthalpy of rare-earth intermetallics.The use of machine learning in rare-earth intermetallic design has been minimal, largely due to the limited availability of reliable datasets. To overcome this, Dr. Singh and his team have developed an extensive 'in-house' rare-earth database, containing over 600 compounds. Each entry in this database is enriched with formation enthalpy data and associated atomic features obtained using high-throughput density-functional theory...2022-05-071h 41Science SocietyWeekly recap Aril 25-30 2022Did you miss our rooms this week? Would like to have a short summary of our weekly guest speaker talks? Do you still have a question about a topic we discussed? Join us for the weekly recap!2022-05-0741 minScience SocietyBuilding blocks of life form on space dust: Understanding Interstellar Organic Molecules with Dr. KrasnokutskiIn this intriguing episode, we chat with Dr. Krasnokutski about the fascinating subject of organic molecules present in the dense interstellar medium. Dr. Krasnokutski sheds light on how these complex molecules come into being under typical space conditions and their potential implications for understanding the origins of life.Scientists have managed to synthesize many of these molecules in laboratory conditions mimicking interstellar environments. Still, up until now, only relatively small molecules of biological interest have been shown to form. Dr. Krasnokutski and his team push the boundaries of this understanding, demonstrating the formation of isomeric polyglycine monomers...2022-04-301h 29Science SocietyExploring Perception and Causality: How Human Vision Reconstructs Time with Dr. BechlivanidisIn this thought-provoking episode, we delve into the intriguing realms of perception and causality with Dr. Bechlivanidis. The intuitive assumption that perception of temporal order requires no inference is challenged in this conversation, opening up fascinating discussions around how we interpret and interact with the world around us.Our perception is fundamentally tasked with inferring the most plausible source of sensory stimulation. But what if our assumptions about the order of sensory signals arriving aren't always as straightforward as we believe? Dr. Bechlivanidis introduces us to a novel perceptual illusion that questions this intuitive belief....2022-04-291h 36Science SocietyExploring Learning-Induced Long Noncoding RNAs with Dr. Bredy: Junk DNA could be key to controlling fearIn this enlightening episode, we engage in a deep exploration of the role of long noncoding RNAs (lncRNAs) in learning processes, focusing particularly on fear-related learning, with Dr. Bredy. His breakthrough research has uncovered a substantial population of lncRNAs that respond in adult mice's infralimbic prefrontal cortex to fear-related learning.Dr. Bredy and his team used an advanced technique called RNA Capture-seq to identify these lncRNAs, supplementing these findings with cell-type-specific ATAC-seq applied to neurons selectively activated by fear extinction learning. Through this approach, they discovered 434 inducible lncRNAs that originate from enhancer regions near protein-coding genes.2022-04-291h 36Science SocietyQuantum Batteries: Pushing the Limits of Charging Power with Dr. Gyhm and TeamIn this riveting episode, we discuss the cutting-edge technology of quantum batteries with Dr. Gyhm and his research team. Quantum batteries are sophisticated devices made from quantum states that store and release energy with impressive speed and efficiency. Their promise of significantly increased charging speed compared to classical batteries due to entangling charging operations, positions them as potentially revolutionary for future technological applications.Dr. Gyhm's team reveals the maximal speedup achievable in quantum batteries, which is extensive in the number of cells. This insight indicates a potential quadratic scaling in the charging power compared to the linear...2022-04-282h 05Science SocietyHigh-Frequency Mechanostimulation in Stem Cell Differentiation with Dr. LizebonaIn this episode, Dr. Lizebona discusses a fascinating development in the field of stem cell research: the targeted differentiation of stem cells through high-frequency mechanostimulation. Contrary to past research that saw little benefit in applying frequencies beyond 1 kHz, Dr. Lizebona's team shows that MHz-order mechanostimulation can successfully trigger the differentiation of human mesenchymal stem cells from various donor sources toward an osteoblast lineage.By using nanoscale amplitude surface reflected bulk waves, they show that even short, early stimuli can induce long-term osteogenic commitment. Remarkably, rapid treatments of high-frequency (10 MHz) mechanostimulation have led to significant upregulation in early...2022-04-261h 13Science SocietyWeekly recap April 18 till 24Did you miss our rooms during the week? We will give a short summary of what we discussed with our guest speakers this week. Join us!2022-04-261h 22Science SocietyUnlocking the Mind's Eye: How Imagery Shapes What We See with Dr. Fukuma & Dr. YanagisawaDive into a groundbreaking study from the prestigious Osaka University, where researchers venture into the captivating world of visual perception and mental imagery. How does what we imagine influence what we actually see? Using advanced brain-computer interfaces and unique semantic space, they uncover the intricate dance between attention, imagery, and our neural representations. Plus, discover the promising implications of their research for individuals with paralysis and ALS. Join us as we illuminate the unseen pathways of the mind's eye! Keyword List: Visual Perception, Mental Imagery, Osaka University, Brain-Computer Interfaces (rBCI), Neural Representations, Semantic Space Attention vs. Imagery...2022-04-231h 12Science SocietyLung Cancer Risk in Smokers: The Rate of Somatic Mutation Accumulation with Dr. Zhenqiu HuangIn this enlightening episode, Dr. Zhenqiu Huang from the Department of Genetics at Albert Einstein College of Medicine delves into the intriguing world of lung cancer risk among smokers. While it's known that the risk is dependent on the dose of smoking, the mystery surrounding whether this increased risk is a result of an uptick in the rate of somatic mutation accumulation in normal lung cells remains. Through extensive research, including single-cell whole-genome sequencing and analysis of both age and smoking status, Dr. Huang and his team have unraveled some of these enigmas. Listen in to understand why most...2022-04-231h 29Science SocietyMaximally Entangled Protons: Deep Inelastic Scattering & the Entanglement of Partons with Dr. KutakJoin Dr. Krzysztof Kutak from the Institute of Nuclear Physics at the Polish Academy of Sciences as we delve into the intricate world of protons and partons. Investigate the proposal by Kharzeev and Levin on maximally entangled proton wave functions in Deep Inelastic Scattering. Unpack the relationships between parton numbers, final state hadron multiplicity, and discover how these intricate elements may not be as they seem at first glance. Kutak's team throws a fresh light on this by considering the sum of gluon and quark distribution functions. Find out how their approach aligns with H1 data and challenges existing...2022-04-231h 13Science SocietyDynamic Vision: DETI Mapping & The Evolution of the Visual Code with Dr. Bruce HansenStep into the captivating world of visual neuroscience with Dr. Bruce Hansen, a pioneering figure in neuroimaging techniques. The eyes are said to be the windows to the soul, but how exactly does our brain interpret the endless streams of visual information we encounter daily? Dive deep into the intricacies of how real-world scenes are processed within our minds. While traditional imaging methods like fMRI have offered insights, they often miss the dynamic aspect of the visual code. Enter the innovative DETI (Dynamic Electrode-to-Image) mapping, a technique that harnesses the power of EEG's high temporal resolution to give us...2022-04-231h 46Science SocietyDecoding Alzheimer's: Astrocytes, α2-NKA, and the Path to Potential Therapies with Dr. GallardoJoin Dr. Gallardo, a distinguished alumnus of the University of Texas Southwestern Medical School, as he unveils his groundbreaking research from the laboratory of Dr. Thomas C. Südhof. Alzheimer's disease is notorious for its amyloid plaques and tau tangles. But there's more to this devastating disease – the hidden culprits known as reactive astrocytes. Dr. Gallardo explores the potential connection between these astrocytes and the pathophysiology of Alzheimer’s and other tauopathies. Dive deep into his fascinating studies on astrocytic α2-Na+/K+ ATPase (α2-NKA) and its implications in the neurodegenerative process. Uncover how targeting this pump or inhibiting its activit...2022-04-231h 26Science SocietyDecoding FOXG1: Insights into Brain Cell Growth with Dr. Ernst @ McGill UniversityDive into the microscopic realm of neural progenitor cells with Dr. Ernst of McGill University as we delve into the intricacies of FOXG1—a gene exclusively expressed in the brain—and its profound implications. From microcephaly to severe intellectual disabilities, the role of FOXG1 is more integral than previously thought. In a groundbreaking study, Dr. Ernst and his team meticulously modeled FOXG1 syndrome using cells from diagnosed patients and controls. The revelations? Cells with a FOXG1 loss demonstrated a marked reduction in proliferation, a skewed cell cycle ratio, and an intriguing increase in primary cilia. But what happens when the...2022-04-191h 59Science SocietyUnlocking the Secrets of Epigenomic Regulation with Dr. LevyJourney with Dr. Levy into the heart of cellular fate determination and the role of the polycomb repressive complex 2 (PRC2) in it. Histone 3 lysine 27 methylation (H3K27me3) marks, crucial for cellular bifurcation during development, have remained a mystery—until now. Dr. Levy introduces the cutting-edge EBdCas9 technology, a fusion of a computationally designed protein and the infamous dCas9, to shed light on this enigmatic process. When targeted at specific genes, this tool reveals precise locations where H3K27me3 and EZH2 operate, leading to fascinating insights such as the discovery of a functional distal TATA box upstream of th...2022-04-191h 43Science SocietyWeekly recap April 11 til 16n2022Did you miss our rooms during the week? We will give a short summary of what we discussed with our guest speakers this week. Join us!2022-04-191h 42Science SocietyBreaking Barriers in Embryo Research: Ex utero mouse embryogenesis with Dr. Alejandro A-CastrejonStep into the cutting-edge world of embryogenesis with Dr. Alejandro A-Castrejon from the Weizmann Institute of Science. While our grasp on the early stages of mammalian development has steadily grown over the years, the phase after implantation into the maternal uterus has remained somewhat elusive. But all that is about to change.Dr. Alejandro A-Castrejon unveils groundbreaking platforms for the ex utero culture of post-implantation mouse embryos. This transformative approach allows researchers to mimic in utero development precisely from before gastrulation (at embryonic day, or E, 5.5) up until advanced organogenesis stages (E11) – all outside the womb. With a...2022-04-181h 17Science SocietyUnlocking New Frontiers in ALS Research with Dr. Van ZundertDr. Van Zundert invites us on an enlightening journey into the intricate world of neurodegenerative diseases, specifically amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These disorders have puzzled researchers for years, especially given the involvement of non-cell-autonomous mechanisms where toxic factors released by astrocytes lead to motorneuron (MN) damage. The heart of this mystery? A compound known as inorganic polyphosphate (polyP).Delving deep into his research, Dr. Van Zundert unveils a startling discovery. Astrocytes derived from mice and patient-induced pluripotent stem cells (iPSCs) with mutations linked to ALS/FTD (including SOD1, TARDBP, and C9ORF72) exhibit...2022-04-181h 24Science SocietyPotential Supplement for Longer Lifespan: Deciphering Fat's Role in Longevity with Dr. BohnertIn a riveting conversation with Dr. Bohnert, we uncover the mysteries surrounding the biological process of aging. Contrary to popular belief, aging isn't a chaotic decline but a process governed at the molecular level. The spotlight today is on a unique botanical extract from Artemisia scoparia (SCO), which has been shown to promote fat storage, metabolic resiliency, and notably, extend the life span of the nematode Caenorhabditis elegans by an astonishing 40%.Dr. Bohnert details how SCO's magic lies in its ability to elevate levels of unsaturated fats in worms. Inhibiting certain enzymes, which oversee the biosynthesis of...2022-04-181h 38Science SocietyUnlocking the Right Sleep: How Elite Sleepers Might Hold the Key to Battling Alzheimer's with Dr. FuIn a groundbreaking study from Dr. Ying-Hui Fu's team at the University of California, we delve into the intriguing world of Familial Natural Short Sleepers (FNSS). These individuals, who naturally sleep less yet face no cognitive decline, might offer insights into slowing Alzheimer's disease. Join us as we discuss the compelling link between sleep quality and neurodegenerative disorders and how FNSS genetic mutations could become our secret weapon against Alzheimer's.Keyword List:Familial Natural Short Sleepers (FNSS)Alzheimer's disease (AD)Genetic mutationsDEC2-P384RNpsr1-Y206...2022-04-181h 10Science SocietyWeekly recap Aril 4-9 2022Did you miss our rooms this week? You don’t have enough time to listen to hours of replays? Join our weekly recaps. We will give a short summary of the week! Join us!2022-04-1853 minScience SocietyElectrodynamic Forces and Life: A New Layer in the Intricacies of Molecular Biology with Dr. PettiniLong-distance electrodynamic intermolecular forcesUncover the groundbreaking work of Marco Pettini and his team, who reveal a surprising force at play in the dance of biomolecules. With the use of two pioneering experiments, they bring to light the existence of long-range electrodynamic (ED) forces between molecules—forces that, until now, remained theoretical. These forces could dramatically change our understanding of cellular dynamics, potentially speeding up certain cellular processes and perhaps even playing a role in drug design. Dive deep with us as we explore this thrilling frontier, ponder its implications in evolution, and imagine its potential uses in...2022-04-102h 07Science SocietyHoarding Disorder in Adults with ADHD: An Overlooked Association with Dr. MoreinIn today's episode, Dr. Morein enlightens us about an often under-recognized condition: Hoarding Disorder (HD). Traditionally associated with Obsessive-Compulsive Disorder (OCD), recent insights suggest a surprising connection between HD and Attention Deficit/Hyperactivity Disorder (ADHD).Main Points:Background on Hoarding Disorder (HD):HD remains under-recognized and inadequately treated.Though it generally manifests by early adulthood, most patients only seek help later in life, often leading to research predominantly focusing on older females.HD vs. OCD:Historically, HD was considered a variant of OCD.However, recent...2022-04-101h 19Science SocietyCarbon-Negative Fermentation for Sustainable Acetone and Isopropanol Production with Dr. LeangDr. Leang and team have developed a pioneering carbon-negative fermentation technique to produce industrial chemicals, specifically acetone and isopropanol, using waste gases like industrial emissions and syngas. Through extensive metabolic engineering and optimization strategies, the team was able to achieve production rates of up to 3 g/L/h and selectivity of ~90%. The approach not only sidesteps the use of sugars (a common but economically challenging feedstock) but also has the added benefit of utilizing greenhouse gases, thus mitigating their environmental impact.Key Points:Waste Gases as Feedstock: While sugar fermentation has its limitations due to...2022-04-1000 min
Science SocietyDr. Leang: Carbon-negative production of acetone/ isopropanolhttps://doi.org/10.1038/s41587-021-01195-w Many industrial chemicals that are produced from fossil resources could be manufactured more sustainably through fermentation. Here we describe the development of a carbon-negative fermentation route to producing the industrially important chemicals acetone and isopropanol from abundant, low-cost waste gas feedstocks, such as industrial emissions and syngas. Using a combinatorial pathway library approach, we first mined a historical industrial strain collection for superior enzymes that we used to engineer the autotrophic acetogen Clostridium autoethanogenum. Next, we used omics analysis, kinetic modeling, and cell-free prototyping to optimize flux. Finally, we scaled up our...2022-04-102h 16Science SocietyDecoding Human Uniqueness: microRNA Genes and Our Evolutionary Journey with Dr. LentsToday's episode welcomes Dr. Nathan Lents, who shares enlightening revelations about the genetic foundation of what sets humans apart from other apes. Using an array of advanced tools and methods, Dr. Lents and his team embarked on a journey to uncover the mysteries of the human genome.The Quest for Human Uniqueness:The genetic underpinnings of our unique human traits remain an area of profound intrigue in biological anthropology.Approach and Methods:By employing genome alignment tools, the team aimed to find islands of DNA sequences that aren't conserved among species.2022-04-101h 05Science SocietyUnlocking Ice's Secrets: Transitions, Symmetries, and H-Bond Dynamics with Dr. Salamat: ExogeologyIn today's episode, we're diving deep into the mysterious world of ice structures with Dr. Salamat. By utilizing advanced techniques like X-ray diffraction and Raman spectroscopy, his research provides novel insights into the transitions and behavior of ice under extreme conditions.Methods and Techniques:The study combined the use of X-ray diffraction and Raman spectroscopy. Grain normalizing heat treatment was achieved via direct laser heating, ensuring precise results.Transition from Ice-VII to Ice-VIIₜ:At pressures around 5.1 ± 0.5 GPa, a transition was observed from cubic ice-VII to tetragonal symmetry, denoted as ice-VIIₜ.H-B...2022-04-102h 22Science SocietyWeekly recap Mar 28 till April 2 2022Did you miss our guest speaker sessions? Is listening to hours of replays too time-consuming? Join us for the weekly recap rooms!2022-04-102h 09Science SocietyMimicking the Brain: The Promise of Organic Neuromorphic Electronics with Dr. Paschalis GkoupidenisToday's episode delves into the captivating realm of neuromorphic electronics with expert Dr. Paschalis Gkoupidenis. He presents a groundbreaking exploration into emulating the brain's functional connectivity using organic neuromorphic devices.The Brain's Dynamic Binding:Neural populations in the brain synchronize through global oscillations, creating functional connectivity. This adaptability surpasses the hardwired structure, enabling complex, versatile computational systems. Current Limitations in Neuromorphic Architecture:Existing neuromorphic designs have yet to capture the fluidity of biological functional connectivity. Functional Connectivity via Organic Neuromorphic Devices:Arrays of organic neuromorphic devices were...2022-04-031h 41Science SocietyBeyond Divergent Thinking: A Dive into Narrative Theory and Creativity with Dr. FletcherToday, we venture into the intricate world of creativity with Dr. Fletcher. As an essential source of innovation and adaptability, understanding creativity has become vital for numerous sectors. Join us as Dr. Fletcher introduces an alternative approach to understanding and training creativity through narrative theory.Reevaluating Creativity Training:Creativity's value is undisputed; yet, the foundational training technique, divergent thinking, has its limitations. Concerns include its incongruence with the creative processes observed in children and many adults, and its underwhelming results.Introducing Narrative Theory to Creativity:Dr. Fletcher proposes narrative theory as...2022-04-031h 27Science SocietyShining New Light on Chiral Molecules: Innovations in CPL Bio-Imaging with Dr. MacKenzieToday, we delve into a groundbreaking frontier in bio-imaging with Dr. MacKenzie, who is pioneering methods to observe and understand the world of chiral molecular interactions – an area that, up to now, was challenging to visualize.The Significance of Chirality:Life's molecular machinery relies on chiral building blocks, yet monitoring these in live cells remained elusive.Luminescent chiral molecules provide a unique optical signature, shedding light on the environment, shape, and binding state.Introducing the CPL Laser Scanning Confocal Microscope (CPL-LSCM):This revolutionary device can capture chiroptical contrast in li...2022-04-031h 38Science SocietyExploring Quantum Phases: From Equilibrium to the Discrete Time Crystal with Dr. Pedram RoushanJoin us today with Dr. Pedram Roushan from Google Research as we dive deep into the world of quantum many-body systems. We'll explore the fascinating phenomena of dynamical phases and the concept of discrete time crystals (DTC), revealing the wonders of out-of-equilibrium quantum systems.Nature's Non-equilibrium State:Quantum many-body systems have rich phase structures in low-temperature equilibrium states.However, nature often exists out-of-equilibrium, leading to intriguing dynamical phases not seen in equilibrium.The Novelty of Dynamical Phases:Recent predictions suggest dynamical phases might exist that are forbidden by conventional...2022-04-031h 26Science SocietyWeekly Science Society Recap Mar 21 till 27 2022Did you miss our rooms? Did you have more questions comments that we didn’t have time to clarify? Join our weekly recap rooms! We will give a summarized overview of what our guest speakers presented.2022-04-0358 minScience SocietyLithium and Dementia: A New Hope for Prevention? with Dr. ChenIn today's episode, we're joined by Dr. Chen to discuss a pressing concern for the elderly: dementia. As one of the primary causes of death among senior Western populations, the race is on to find treatments or preventive measures for dementia. Dr. Chen enlightens us about an intriguing potential solution: lithium.The Dementia Dilemma:Dementia stands as a dominant cause of death in elderly Westerners.Despite extensive research, no disease-modifying treatments are currently available.Lithium: A Potential Answer?Lithium, typically known for its psychiatric applications, has been proposed as...2022-04-031h 02Science SocietyZentropy Theory: Understanding Temperature and Volume Anomalies in Materials with Dr. LiuToday we welcome Dr. Zi-Kui Liu, a distinguished figure in the realm of Materials Science. With a career spanning decades and encompassing education, research, leadership, and entrepreneurship, Dr. Liu has made significant contributions to our understanding of materials and their properties.Dr. Zi-Kui Liu's Journey:Dr. Liu's academic journey took him from Central South University to University of Science and Technology Beijing, culminating with a PhD from the Royal Institute of Technology, Sweden. His professional career has seen him take on roles at University of Wisconsin-Madison, Questek Innovation, LLC, and a longstanding association with The...2022-03-272h 11Science SocietyMapping the Mind: Psychedelics, Consciousness, and the Brain with Dr. Danilo BzdokIn this intriguing episode with Dr. Danilo Bzdok, we delve deep into how psychedelics potentially influence our consciousness by altering the way our higher association cortex processes sensory signals. By examining 6,850 testimonials on 27 different drugs and comparing them against 40 neurotransmitter receptor subtypes, Dr. Bzdok paints a comprehensive picture of the connection between drug-induced changes in awareness and their corresponding locations in the brain. The result? An innovative approach that highlights how our experiences with these substances relate to the balance between higher-level association and sensory input. Discover how the intricate dance between language, the brain, and consciousness can shed...2022-03-271h 44Science SocietyThe Adhesive Dance: Neurite Placement and Circuit Formation with Dr. Titas SenguptaIn an engaging conversation with Dr. Titas Sengupta, we delve into the intricate processes guiding the placement of neurites in specific neural layers during brain development. Utilizing groundbreaking imaging techniques and advanced quantitative models, Dr. Sengupta unveils his findings on the embryonic development of the C. elegans brain neuropil. At the core of this exploration lies the profound role of differential adhesion, orchestrated by the interaction between IgCAM SYG-1 and its ligand partner, SYG-2. Rather than the anticipated outgrowth method, neurites are found to employ a unique "retrograde zippering" mechanism, which governs their precise placement. Through this study, Dr...2022-03-271h 07Science SocietyDr. Habchi and Dr. Jawed: How spiders flyhttps://doi.org/10.1103/PhysRevE.105.034401 In this paper, three-dimensional numerical simulations of ballooning in spiders using multiple silk threads are performed using the discrete elastic rods method. The ballooning of spiders is hypothesized to be caused by the presence of the negative electric charge of the spider silk threads and the positive electric potential field in the Earth's atmosphere.2022-03-2700 minScience SocietyElectric Ballet: Deciphering the Secrets of Spider Ballooning with Dr. Habchi and Dr. JawedIn a captivating conversation with Dr. Habchi and Dr. Jawed, we take a deep dive into the enigmatic world of spider ballooning. Using state-of-the-art three-dimensional numerical simulations and the discrete elastic rods method, they explore the hypothesis that spiders' ballooning mechanism is influenced by the electric charge dynamics between spider silk threads and the Earth's atmospheric electric potential. Validated with experimental data, their research examines two unique cases of electric charge distribution: uniformly spread across the threads and concentrated at the thread tip. Intriguing findings reveal how terminal ballooning velocity is affected differently in both cases, with a striking...2022-03-271h 59Science SocietyBeyond Menopause: FSH's Role in Alzheimer's and New Frontiers in Treatment with Dr. Keqiang YeIn this enlightening episode with Dr. Keqiang Ye, we journey into the fascinating connection between Alzheimer's disease and rising levels of follicle-stimulating hormone (FSH) in the body, particularly during the menopausal transition. With alarming evidence suggesting an accelerated cognitive decline in older women, Dr. Ye reveals groundbreaking research that shows FSH’s direct influence on neurons, contributing to the development of Alzheimer’s. Interestingly, blocking FSH’s action shows not only potential in treating Alzheimer’s but also other conditions like obesity, osteoporosis, and dyslipidaemia. As we move away from traditional beliefs about pituitary glycoproteins and acknowledge their broader influenc...2022-03-272h 14Science SocietyDr. Li (NIH): Mitochondria act as microlenses in cone cellshttps://doi.org/10.1126/sciadv.abn2070 Mammalian photoreceptors aggregate numerous mitochondria, organelles chiefly for energy production, in the ellipsoid region immediately adjacent to the light-sensitive outer segment to support the high metabolic demands of phototransduction. However, these complex, lipid-rich organelles are also poised to affect light passage into the outer segment. Here, we show, via live imaging and simulations, that despite this risk of light scattering or absorption, these tightly packed mitochondria “focus” light for entry into the outer segment and that mitochondrial remodeling affects such light concentration. This “microlens”-like feature of cone mitochondria delivers light with an angular dependen...2022-03-201h 47Science SocietyHarnessing piRNAi for Advanced Gene Silencing: Deep Dive with Dr. PriyadarshiniIn the episode featuring Dr. Priyadarshini, the spotlight is on the innovative use of single-guide Piwi-interacting RNAs (piRNAs) to guide the piRNA pathway for specific gene silencing in the Caenorhabditis elegans organism, which encompasses the hermaphrodite germline, sperm, and embryos. Termed as piRNA-mediated interference (piRNAi), this method presents a more efficient and scalable approach than traditional RNAi. A unique characteristic of piRNAi is its ability for conditional gene silencing and induction of transgenerational epigenetic silencing, suggesting its potential for in-depth studies on transgenerational inheritance. When benchmarked against other gene-silencing methods, piRNAi stands out for its programmability and efficiency. However...2022-03-201h 08Science SocietyBreaking antimicrobial resistance by Dr. Mavridouhttps://doi.org/10.7554/eLife.57974 Antimicrobial resistance in Gram-negative bacteria is one of the greatest threats to global health. New antibacterial strategies are urgently needed, and the development of antibiotic adjuvants that either neutralize resistance proteins or compromise the integrity of the cell envelope is of ever-growing interest. Most available adjuvants are only effective against specific resistance proteins. Here, we demonstrate that disruption of cell envelope protein homeostasis simultaneously compromises several classes of resistance determinants.2022-03-2000 minScience SocietyDr. Mavridou on Antibiotic Resistance and Bacterial ProteostasisNovel Strategy to Tackle Antibiotic Resistance: Dr. Mavridou's research presents a novel approach to combat antibiotic resistance. By targeting a single non-essential bacterial protein, DsbA, the team was able to inhibit multiple antibiotic resistance (AMR) determinants.DsbA and its Role: DsbA, a protein unique to bacteria, plays a significant role in the function of various resistance enzymes. By inhibiting this protein, the research team managed to sensitize certain pathogens to existing antibiotics, making those drugs effective once again.β-lactamase Enzymes and DsbA: A significant focus was placed on β-lactamase enzymes, which confer resistance to a ra...2022-03-201h 26Science SocietyDr. Cunningham on White Dwarf Atmospheres and AccretionDr. Cunningham's findings throw fresh light on the enigmatic heavy-element pollution in white dwarf atmospheres. With the direct evidence from X-rays and the newly deduced accretion rates, the research reshapes our understanding of the processes at play in these ancient stellar remnants and suggests a need for refined models to fully capture the complexities unfolding in these stars.White Dwarf Pollution: A significant number of white dwarf stars possess atmospheres tainted by heavy elements. These elements, intriguingly, should vanish from sight in a relatively short time due to gravitational settling.Accretion Hypothesis: The presence of...2022-03-201h 09Science SocietyDr. Cocucci on Curvature in Endocytic Clathrin CoatsEndocytic Clathrin Coats and Curvature: The episode kicks off with an introduction to endocytic clathrin coats. These are structures that form on a cell's surface to help internalize extracellular molecules. An essential step in this process involves curving a flat piece of the cell membrane into a vesicle, which the endocytosis machinery facilitates.Initial Findings: Contrary to previous beliefs, the formation of clathrin pits doesn't depend on a late-stage flat-to-curved transition. The curvature actually starts developing from the early stages of their formation. This revelation challenges existing models of clathrin coat formation. Additionally, membrane tension, or the...2022-03-2000 minScience SocietyMeet author Dr. Cocucci: experiments show how cells ‘eat’https://doi.org/10.1016/j.devcel.2021.10.019 A new study shows how cell membranes curve to create the "mouths" that allow the cells to consume things that surround them. The study, published last month in the journal Developmental Cell, found that the intercellular machinery of a cell assembles into a highly curved basket-like structure that eventually grows into a closed cage. Scientists had previously believed that structure began as a flat lattice. Membrane curvature is important, Kural said: It controls the formation of the pockets that carry substances into and out of a cell.2022-03-201h 57Science SocietyDr. Rhee on The Interplay of Musicality and Linguistic Pitch Development in ChildrenComplex Nature of Vocal Pitch: Dr. Rhee reiterates that vocal pitch isn't just about the F0 (fundamental frequency). It encompasses both F0 and other acoustic cues, which are crucial for linguistic understanding.Musicality and Pitch in Language Development: Recent studies suggest that musicality influences how learners develop pitch perception in sentence intonation and prosodic emphasis. Dr. Rhee’s research delves deep into this relationship, focusing on Mandarin—a tonal language.Research Methodology: 43 Mandarin-speaking children (ages 4 to 6) were tested on tone production and musicality. The study measured how contrasting their tones were across age and musicality leve...2022-03-201h 45Science SocietyDr. Alonim on Early Autism Detection and InterventionOrigins of the Study: Researchers at Bar-Ilan University, including Dr. Hanna A. Alonim from the Weisfeld School of Social Work Continuing Education Unit, spearheaded two vital studies, focusing on early autism detection and intervention.10-year Long Study with 110 Infants: Before being diagnosed with ASD at ages 2-3, video recordings of these infants during their first year, shot by unsuspecting parents, were examined. Several autism traits were discerned, such as an aversion to touch, delayed motor skills, erratic activity levels, limited reactions, an accelerated head growth rate, eating resistance, and lack of eye contact. Furthermore, the interplay between...2022-03-201h 11Science SocietyDr. Bellone on SHANK3 Gene Mutations and AutismDr. Bellone discusses how mutations in the SHANK3 gene are a recognized genetic risk factor for Autism Spectrum Disorder (ASD).It's noted that while these mutations are typically associated with autism in humans, mice with heterozygous deletion of the Shank3 gene don't typically show ASD-like behaviors.1. Role of the Shank3 gene in mice: - Downregulating the Shank3 gene in the Nucleus Accumbens of neonatal mice results in increased excitability in specific neurons and impairs social behavior. - When genetically vulnerable mice are exposed to inflammation, they display similar behavioral changes. These...2022-03-131h 13Science SocietyThe Gut-Brain Connection: Decoding 4EPS and Behavioral Impacts with Dr. NeedhamIn a revealing interview with Dr. Brittany Needham, listeners are introduced to the profound relationship between gut microbiota and brain behavior. Dr. Needham's study uncovers the role of a specific gut-derived molecule, 4EPS, in influencing neurodevelopment in mice. The episode delves into the journey of dietary tyrosine's conversion into 4EPS, the impact of bioengineered bacteria on mouse behavior, and the pivotal role of oligodendrocytes in the myelination of neuronal axons. Notably, the episode sheds light on how 4EPS-exposed mice display anxiety-like behaviors and how these effects can be mitigated through specific pharmacological treatments. The conversation underscores the significance of...2022-03-131h 10Science SocietyThe Sleep and Psyche Connection: Unraveling 5-HT2ARs and Schizophrenia with Dr. GallitanoIn a captivating episode featuring Dr. Gallitano, the audience is taken on a deep dive into the intricate relationship between the Serotonin 2A receptors (5-HT2ARs) and their potential role in schizophrenia—a mental disorder marked by perceptual and cognitive anomalies. Dr. Gallitano shares pivotal findings that highlight how sleep deprivation, a commonplace environmental stimulus, can significantly amplify the levels of 5-HT2AR in the mouse frontal cortex in a mere span of hours. The linchpin in this discovery is the gene transcription factor "early growth response 3 (Egr3)," which was found to be critical for this upregulation. Further explorations re...2022-03-132h 29Science SocietyDr. Rinaldi peeks into black holes with quantum computingMatrix quantum mechanics plays various important roles in theoretical physics, such as a holographic description of quantum black holes. Understanding quantum black holes and the role of entanglement in a holographic setup is of paramount importance for the development of better quantum algorithms (quantum error correction codes) and for the realization of a quantum theory of gravity. Quantum computing and deep learning offer us potentially useful approaches to study the dynamics of matrix quantum mechanics. In this paper we perform a systematic survey for quantum computing and deep learning approaches to matrix quantum mechanics, comparing them to Lattice Monte...2022-03-131h 59Science SocietyDeciphering Quantum Gravity with Quantum Computing, Machine Learning, and Holography by Dr. RinaldiEmbarking on the quest to unify quantum mechanics with general relativity has opened doors to a fascinating realm of theoretical physics. Dr. Rinaldi delves deep into the intricacies of matrix quantum mechanics—a tool pivotal for our understanding of quantum black holes and holographic duality. This episode dives into how new-age computational tools, like quantum computing and deep learning, maybe the game-changers we need to truly grasp and solve matrix models, shedding light on enigmas like quantum gravity and the role of entanglement. Join us as we explore how two specific matrix models, akin to those used to study bl...2022-03-1300 minScience SocietyRevolutionizing X-Ray Imaging: Dr. Schwartz's Leap into Advanced Chemical Element MappingIn this riveting episode, Dr. Schwartz takes us on a journey into the intricate world of chemical element mapping—a tool vital for understanding complex materials. Traditional X-ray fluorescence methods, while powerful, are hampered by slow speeds and resolution constraints. Dr. Schwartz introduces a game-changing approach, leveraging computational ghost imaging and compressed sensing to sidestep these challenges. By eliminating the need for focusing and sample movement, his method boosts resolution and slashes measurement time. But that's just the tip of the iceberg! Listen as we explore how this technique can potentially revolutionize medical imaging by enhancing the visibility of so...2022-03-131h 06Science SocietyMicrodosing LSD: Myth or Magic? Dr. Molla's Deep Dive into Psychedelic ScienceIn this compelling episode, we join Dr. Molla as she delves into the controversial and widely-debated practice of microdosing with LSD. Amidst the backdrop of a psychedelic renaissance in mental health, thousands assert that taking minimal amounts of LSD can elevate mood and sharpen cognitive prowess. But is there scientific weight behind these claims? Dr. Molla walks us through her meticulous double-blind controlled study, which explores the effects of small LSD doses on mood, cognition, and emotional responsiveness. The findings might surprise many ardent microdosing proponents. Listen in to uncover the truth about this modern practice—demystifying myths, highlighting nu...2022-03-131h 35
HandstandtalkHandstandtalk #206 - Catarina PachecoCatarina Pacheco - Engenheira de Gestão industrial, co-fundadora da empresa @urockhoney , provavelmente das influencers mais divertidas que vais encontrar no Instagram, fica a conhecer o seu percurso desportivo, profissional e a cara real por tras do filtro silly face. Se ainda não segues a Catarina no Instagram, por favor segue: @catarinapacheca
Ouve, comenta e partilha, deixa aquele like.
Se gostas do conteúdo que partilho e queres apoiar o projecto, agora já podes faze-lo, aqui: https://www.patreon.com/handstandtalk2022-03-1138 minScience SocietyDecoding Anxiety: Dr. Khalsa Sheds Light on the Interoceptive Dysfunctions in GADJoin us on a deep dive into the world of generalized anxiety disorder (GAD) with Dr. Khalsa. This episode unravels the intricacies of how our body perceives internal sensations, especially during heightened moments of anxiety. Why do some individuals feel their heart race or breath quicken more intensely than others? Using a groundbreaking study, Dr. Khalsa investigates how those with GAD respond to β-adrenergic stimulation, a key driver of such symptoms. Leveraging advanced neuroimaging, the research uncovers a distinct relationship between GAD, heart palpitations, dyspnea, and activity in the ventromedial prefrontal cortex. Discover the potential implications of these findings f...2022-03-061h 20Science SocietyChallenging the Norm: Dr. Weigel and Dr. Monroe Explore Evolutionary Mutation BiasMutation has long been understood as a random force in evolution. But what if we've had it wrong all along? In today's intriguing episode, we're joined by renowned evolutionary biologists Dr. Weigel and Dr. Monroe to challenge this long-held notion.Journey into the microscopic world of the plant Arabidopsis thaliana, a model organism in plant genetics, as our guests unveil their groundbreaking research findings. The revelations are startling: mutations occur far less frequently in vital parts of the genome than we've believed. Delve into the extensive datasets, surveys, and experiments that led to this conclusion....2022-03-061h 19Science SocietyDeciphering Predictions: Sounak Mohanta Explores the Brain Mechanics Behind ExpectationsPredicting what comes next is an innate human ability honed through our lifetime of experiences. Imagine hearing a siren and instinctively looking for an ambulance; this seemingly simple act involves intricate brain functions and neural mechanics. In today's episode, we journey into the depths of these mechanisms with Sounak Mohanta, an expert at the intersection of neuroscience, machine learning, and computational frameworks.Using cutting-edge techniques like high-density EEG and Bayesian modeling, Mohanta's research unravels the intricate dance of frontal alpha activity and reaction times, shedding light on how our brains use past information to predict future events...2022-03-061h 18Science SocietyRedefining Fungal Pathogens: Dr. Krasileva on Computational Structural Genomics on Magnaporthe oryzaeIn a world where fungal pathogens wreak havoc on global food production, understanding their arsenal is of paramount importance. Enter the mysterious realm of Magnaporthe oryzae, a notorious fungal attacker, with Dr. Krasileva, our esteemed guest for today's episode.Dive deep as we navigate the vast universe of the fungal pathogen's secreted proteins. Dr. Krasileva unravels her team's ambitious efforts to predict the structures of a whopping 1,854 proteins. Harnessing the power of machine learning and the revolutionary TrRosetta, they're able to map out the intricate designs of these proteins, laying bare potential effectors and virulence factors.2022-02-251h 09Science SocietyTraumatic Stress & Brain Plasticity with Dr. Daniela Kaufer: Increased Myelin Linked to Anxiety and PTSDThis episode delves deep into the fascinating world of brain responses to traumatic stress with esteemed expert, Dr. Daniela Kaufer. Earning her B.Sc. from the Technion Israel Institute of Technology and her Ph.D. from the Hebrew University of Jerusalem, Dr. Kaufer has passionately navigated her academic journey, culminating in her role as Principal Investigator at UC Berkeley. Beyond her remarkable academic pursuits, she finds solace in reading, yoga, meditation, and spending quality time in nature with her family.Dr. Kaufer provides insights from her recent captivating study, which explored the biological variance in reactions to...2022-02-241h 20Science SocietyGuest speaker Dr. Levine presents: Technological Approach to Mind EverywhereSynthetic biology and bioengineering provide the opportunity to create novel embodied cognitive systems (otherwise known as minds) in a very wide variety of chimeric architectures combining evolved and designed material and software. These advances are disrupting familiar concepts in the philosophy of mind, and require new ways of thinking about and comparing truly diverse intelligences, whose composition and origin are not like any of the available natural model species. In this Perspective, I introduce TAME - Technological Approach to Mind Everywhere - a framework for understanding and manipulating cognition in unconventional substrates. TAME formalizes a non-binary (continuous), empirically-based approach...2022-02-241h 33Science SocietyGuest speaker Dr. Jones presents: Stochastic microbiome assembly depends on contextIndividuals are constantly exposed to microbial organisms that may or may not colonize their gut microbiome, and newborn individuals assemble their microbiomes through a number of these acquisition events. Since microbiome composition has been shown to influence host physiology, a mechanistic understanding of community assembly has potentially therapeutic applications. In this paper we study microbiome acquisition in a highly controlled setting using germ-free fruit flies inoculated with specific bacterial species at known abundances. Our approach revealed that acquisition events are stochastic, and the colonization odds of different species in different contexts encode ecological information about interactions. These findings have...2022-02-241h 43Science SocietyRevolutionizing Brain Imaging: Dr. Field on the Compact Kernel Flow TD-fNIRS SystemDelve into the innovative world of brain imaging with Dr. Field as we discuss the latest breakthroughs in noninvasive optical brain imaging tools. The traditional TD-fNIRS system, a benchmark in optical brain imaging, has seen limited adoption due to its complex design and high costs. Dr. Field introduces us to the Kernel Flow, a game-changer that promises to democratize access to high-quality brain imaging.Kernel Flow's brilliance lies in its compactness and modularity, retaining the precision of traditional systems. Dr. Field and his team have ingeniously miniaturized various components, from laser drivers to specialized detectors, resulting in...2022-02-241h 13Science SocietyBridging Quantum and Biology: The Tardigrade's Quantum Dance with Dr. Dumke and TeamIn a groundbreaking episode, Dr. Dumke and his colleagues challenge the boundaries separating quantum mechanics and biological systems, two realms often seen as incompatible. Taking center stage is the tardigrade—a microscopic marvel known for its resilience against harsh conditions. Dr. Dumke's team leverages the tardigrade's unique ability to enter cryptobiosis, unveiling its potential to couple with a superconducting quantum bit and even achieve a state of entanglement. As the narrative unfolds, listeners will be captivated by the tale of this tiny creature's journey through extreme temperatures and pressures, culminating in its revival after a record-breaking stint in a qu...2022-02-242h 08
#ODSCast - Podcast do Movimento ODS Santa CatarinaODSCAST - Carla Inácio da Cunha - Gerente de Projetos no Instituto Nexxera, iniciativa do Grupo Nexxees🎙 Chegamos ao décimo terceiro episódio do #ODSCAST, um bate-papo com os Apoiadores Oficiais do Movimento ODS Santa Catarina.
Nesta edição, a nossa coordenadora de mobilização Camile Bruns conversou com a Carla Inácio da Cunha - Gerente de Projetos no Instituto Nexxera, iniciativa do Grupo Nexxees.
Ela falou sobre como o Grupo Nexxes coloca os ODS na sua gestão, e como a empresa de tecnologia tem buscado repensar e fortalecer práticas no aspecto ambiental, indo além das ações já consolidadas, como a coleta seletiva, educação ambiental e principalmente s...2021-11-3048 min
Tu Podes Mudar a tua VidaCafé Virtual com Catarina BaptistaNova rubrica Café Virtual onde trago convidas(os) especiais, que vem partilhar a sua historia.Hoje tenho como convidada Catarina Baptista.Podes seguir a Catarina: www.catarinabaptista.comSe quiseres inscrever no seu workshop : www.catarinabaptista.com/workshopSegue-me nos links em baixoSite www.luisacunha.ptCanal YouTube https://bit.ly/luisacunhaInstagram https://www.instagram.com/luisa.cunha.terapeuta/Facebook https://www.facebook.com/luisacunhaterapeutaLinkdin https://www.linkedin.com/in/lu%C3%ADsa-martins-cunha-969b8a174/2021-11-0222 min
Conversas de escritório de um Empreendedor OnlineEP.15 - Entrevista ao vivo com Catarina Nogueira Fundadora da United BoutiquesO comércio local é fundamental para a vida das cidades e a chegada do eCommerce afetou de uma forma ou de outra estes negócios. A United Boutiques – outlet online das lojas de marca – dá a estes lojistas a oportunidade de se digitalizarem sem investimento inicial. Lançado no final de novembro de 2019, este marketplace permite que as boutiques vendam online, com grande facilidade, o stock que não venderam nos anos anteriores.
Neste Live falamos com a Catarina sobre quais os desafios, aprendizagens e estratégias que eles estão a usar para crescer num mercado tão competit...2021-07-071h 27
Página Sonora57 # Rubens da Cunha | A guardadora da ponte e outras biografias inventadasOuça três poemas do livro "A guardadora da ponte e outras biografias inventadas", de Rubens da Cunha, lançado em 2020, pela Andarilha Edições.
Ficha Técnica:
Seleção e Roteiro: Luciana Tiscoski (Sesc Palhoça)
Leitura: Julyana Fullin Barco (Sesc Palhoça)
Edição: Marcos Oliveira (Sesc Tijucas)
Trilha: "Alegretto", de Nicolas Munzfeld (Sesc Itajaí), Giulia Franke (Sesc Itajaí) e Peter Allan Ramos (Sesc Balneário Camboriú)
2021-05-0704 min
HandstandtalkHandstandtalk #123 - Catarina NivalovaCatarina Nivalova - Bailarina Profissional, professora de danças orientais, licenciada em desporto, fica a conhecer a sua historia, percurso desportivo e profissional, um pouco da sua arte e o que desenvolve!
Episódio disponível através do link na bio
Ouve, comenta e partilha com os teus seguidores! 2020-12-1446 minHandstandtalkHandstandtalk #55 - Catarina AugustoOlá a todos!! Já está disponível através do link na bio, o episódio da Atleta e Nutricionista Catarina Augusto, fica a conhecer a sua historia e visão sobre a nutrição no desporto. Como sempre, ouve, comenta e partilha!2020-06-0239 minHandstandtalkHandstandtalk #53 - Catarina Oliveira e as CatarinasOlá a todos!! Já está disponível mais um episódio através do link na bio, a primeira experiência a 3 no Podcast, a entrevistada foi a Catarina Oliveira a co-host Catarina Lopes, espero que gostem e se divirtam tanto quanto eu me diverti a gravar este episódio .2020-05-3155 minHandstandtalkHandstandtalk #49 - Catarina LopesOlá a todos!! Já está disponível através do link na bio, o episódio da Catarina Lopes, atleta de Crossfit, fiquem a conhecer a sua historia e como chegou ao Crossfit. Ouçam, comentem e partilhem com os vossos seguidores!2020-05-261h 10
Elizabeth Margot15 As Tudors - Catarina de Aragão Uma Rainha e dois casamentos | Chocolate e HistóriaVenha conhecer a história da primeira esposa e Rainha de Henrique VIII da Inglaterra!!!
Entraremos em uma mundo espanhol e ao mesmo tempo inglês, que estava saindo da Idade Média e entrando no Renascimento, e através de Catarina conseguimos entender isso muito bem!
Ela foi uma única Rainha, mas que para isso teve que ter dois casamentos!
Chocolate de hoje: TWIX
instagram: @elizabethmargot_
2020-03-271h 10