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Authentic BiochemistryAuthentic BiochemistryA priori Metabolic Architectonics V. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 10January25References Guerra, Daniel J. 2024-2025. Biochemistry lectures and unpublished Metaphysics. Front Endocrinol (Lausanne). 2020 Dec.3;11:587189 Int J Mol Sci. 2023 May 16;24(10):8811. Lake, G. 1970."Just Take a Pebble" ELP. https://open.spotify.com/track/3yTk0DOOIqz1MNDW2Bj9P9?si=954782df84764dc8 Hunter-Garcia. 1977.Terrapin station. Grateful Dead. https://open.spotify.com/track/2gdTkM0hL9KQipAx6aUT6L?si=1b3a3d5afa34430d Mozart. WA. 1787. "Eine Kleine Nachtmusik" Serenade 13 in G. Major K.525.and music by Grieg and Prokofiev. https://open.spotify.com/album/5iAlyjqXMlO0JNaZ9jMjHF?si=7...2025-01-111h 11Authentic BiochemistryAuthentic BiochemistryEtOH IV. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra. 01January25References Guerra, Daniel J. 2024 Biochemistry lecture archives Cells.2019 Nov 12;8(11):1424 Front Cell Neurosci 2017 Feb1;11:14. Neuropharmacology 2014.79, April : 1-9 Front Mol Neurosci. 2024 May 22;17:1389100. Byrds. 1971. Byrdmaniax lp https://youtu.be/SEBecV36esY?si=wtSnoWe-fAHZzbNv Porter and Fletcher.1934 "Don't Fence Me In" Bing Crosby and Andrew Sisters (1945) https://youtu.be/ILyuEtGrMwI?si=WpBi9KG9m7dzufW4 2025-01-021h 10Authentic BiochemistryAuthentic BiochemistryAuthentic Biochemistry Podcast. Eventuating Nature of Intrinsic Cell Surface Complexity.V. Dr. Daniel J. Guerra.18NOV24References Biomaterials 2003. Volume 24, Issue 24, November :4385-4415 Guerra, DJ. 2024 Lecture notes Pat Mclaughlin, John Anderson, Daniel Quine Auerbach, David R. Ferguson. 2020. "Years." Sierra Ferrell Cover. https://youtu.be/_2W8kCk1qnU?si=4LBcoO5uE3xdEX-c Corelli. A. 1714. Concerto in D Major Op. 6 No. 4 https://youtu.be/3smZkpqXYHs?si=-fEef0QiBAz_1yWm 2024-11-1937 minAuthentic BiochemistryAuthentic BiochemistryNUcleotide Biochemistry Primer II. Authentic Biochemistry Podcast VIDEO. Dr. Daniel J. Guerra. 06.sept24References Anka, P. 1967. My Way. Frank Sinatra https://open.spotify.com/track/2YkIDPL5lGhRhomCq4S2RO?si=f3478e9330614687 Les Brown, Ben Homer, and Bud Green 1945. "Sentimental Journey". Doris Day https://open.spotify.com/track/1SEi94JQIpkMGPAfOafNhH?si=ba4ba19ae8b547b3 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support2024-09-061h 00Authentic BiochemistryAuthentic BiochemistryImmune and neuropathophysiology of CYTOEPIGENETICS Dr. Daniel J. Guerra 18AUGUST 202References Guerra, Daniel J. 2022. December Journal of Disease and Global Health.DOI: 10.56557/jodagh/2022/v15i38023 Lamm, R. 1969. "Beginning's" CTA. https://youtu.be/lI-BMDnti4c?si=ZCt7yL3xRRrH2l_b 2024-08-1938 minAuthentic BiochemistryAuthentic BiochemistryAuthentic Biochemistry Podcast. “Scientism non fengo” Dr Daniel J. Guerra 02August24References Guerra, DJ. 2024. unpublished Sarasate, P.de, 1881. The Carmen Fantasy, Op. 25. https://youtu.be/sYh0fnhKJEo?si=uRDSfFyNgI2o_fNs Anderson,Squire, Bruford,Wakeman. 1971."Heart of the Sunrise" Yes, [Fragile,lp.] https://youtu.be/0vNcgL9Fi4w?si=szH6TVaeyHy_vc2D 2024-08-031h 01Authentic BiochemistryAuthentic BiochemistryPhotosynthesis. IV. Authentic Biochemistry Podcast. Dr Daniel J. Guerra.31.7.24References Guerra, DJ 2024. Lecture material Anderson and Howe 1972. "Close to the Edge" Yes. https://youtu.be/51oPKLSuyQY?si=p1MBzMqcJ8QHpAb-2024-08-0148 minAuthentic BiochemistryAuthentic BiochemistryAuthentic Biochemistry Midsummer Lecture Series. Plant Biochemistry Interlude. Photochemistry I. Dr Daniel J. Guerra 26.7.24References Guerra, DJ.2024. Lecture notes Plant Cell. 2013 Jul; 25(7): 2661–2678 Peer J. 2023; 11: e15696 Gilliland and Massey. 1955. Sid King and the 5 Strings. "Sag, Drag and Fall." https://youtu.be/9KJzeOmHgc4?si=4GjA5H4stZDDl9nT 2024-07-271h 19Authentic BiochemistryAuthentic BiochemistrySaturday evening biochemical metaphysics. Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 20.7.24References Guerra, DJ. 2024. Unpublished material. La Flame and baker. 1970. Its a Beautiful Day. "Hot Summer Day" https://youtu.be/PUXOSe_m_dc?si=752n4PanhqKP8nFv2024-07-2140 minAuthentic BiochemistryAuthentic BiochemistryThe Prevailing Gignesthai of Biological Systems: “In inceptum finis est”.Dr. Daniel J. Guerra. Authentic Biochemistry Podcast. Lectures on Biochemical Epistemology.14.7.24References Guerra, DJ. 2024. Unpublished works Schubert, F. 1827. Piano Trio No. 2, op. 100 (D929) https://youtu.be/yFyv7c1XyYU?si=T0VYKT-EJ5wQmQZU Moody Blues. 1968. In Search of the Lost Chord lp. https://youtu.be/gEj3NOW_ctw?si=Uwc1evf38wMAXdJ_ 2024-07-151h 08Authentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry. Authentic Biochemistry Podcast Multiple Myeloma Sphingosine 1-P Associations. B cells lecture c.17 Fine (c) July7, 2024 Dr Daniel J. GuerraReferences Guerra, DJ. 2024. Lipid lectures. Blood Cancer J. 2024 Dec; 14(1): 24 Haydn.JM.1771. Requiem Mass in C Moll. https://youtu.be/0ywDPn2Ykks?si=hkL4RzjRl7WbiVER Mann, M . 1978. "Institute Chicago" Manfred Mann Earth Band. [Watch, lp] https://youtu.be/99306Peyit0?si=dQgB8m7_TmkRpXsW 2024-07-071h 02Authentic BiochemistryAuthentic BiochemistryDialectical Synthesis Lecture III. The Necroptotic event in cell fate through the lens of categorical synthesis of the a priori. Dr Daniel J. Guerra. authentic Biochemistry Podcast 28.6.24References Guerra, DJ. 2024. unpublished writings. Seminars in Cell & Developmental Biology2020. 99:86-95 2024-06-2844 minAuthentic BiochemistryAuthentic BiochemistryDialectical Synthesis Lecture II. 23.6.24 The Apothecary of the Alternative a priori: of Programmed cell death ontology. Dr Daniel J. Guerra Authentic Biochemistry PodcastReferences Cell.2020 Mar 19; 180(6): 1115–1129.e13. Guerra, D.J. 2024. Intellectual materials. Goffin and King. 1962. "Up on the Roof" [Drfifters] https://youtu.be/puM1k-S86nE?si=LXzWj3SqiqHnr3JB Whitfield and Strong. 1969. "War" [Edwin Starr] https://youtu.be/dQHUAJTZqF0?si=bfB-xARpa6aVDwQg Kay and Godon 1963. "Thats Life" [Frank Sinatra] https://youtu.be/TnlPtaPxXfc?si=SmFfhohympSPVKd0 Van Heusen and Cahn 1960. "Aint that a Kick in the Head" 1960 [Dean Martin] https://youtu.be/K7jgZTDLeIs?si=bAKgzzK7mWCDJmyU Marriot and Lane 1968. "Ma...2024-06-2455 minAuthentic BiochemistryAuthentic BiochemistryAuthentic Biochemistry: Dialectical Syntheses Toward an Improved Evaluation of Biochemical Research. Dr Daniel J. Guerra.20.6.24.References Guerra, Daniel J. 2024. Essays and Notes. Blood. 2017 Jun 15;129(24):3237-3244. Bach, JS. 1731. Partita 6 in E Minor https://youtu.be/TCrZyi0Sots?si=8bjua1HY5M_YWuin Simon, P. 1968. "Old Friends" https://youtu.be/c3NYWzHLEZw?si=vheTMVMR7f-2Ebgj 2024-06-2154 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry II.B lymphocyte VDJ recombination is controlled by multiple methyltransferase mechanisms. Dr Daniel J. Guerra. 01June2024.Authentic Biochemistry.References Guerra, DJ. 2024. ImmunoBiochemistry lectures. Commun Biol. 2022; 5: 1292. ACS Chem. Biol. 2017, 12, 4, 958–968 Telemann, GP., 1750. Sonata in D major, TWV 44:1 https://youtu.be/xx8ooc-s7OQ?si=1vAKmdcLroNISa-P Vivaldi, A., 1708. - Gloria (RV 589) https://youtu.be/2eWjQOdYzMQ?si=hYSOqRuXkYUA8ATl 2024-06-0243 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry II. B cells The Methyltransferase regulation of RAG 2. Dr Daniel J. Guerra. 29May24. Authentic Biochemistry PodcastReferences Guerra, DJ. ImmunoBiochemistry lectures 2024. ACS Chem. Biol. 2017, 12, 4, 958–968 Genome Biol. 2005; 6(8): 227 Manfredini, FO. 1718. 12 Concerti Grossi | Op. 3 https://youtu.be/4t-E3wlMkDQ?si=GX0GCLUm48J4V8OY 2024-05-3046 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry II. B Cell Event Ontology. 28May24. Authentic Biochemistry Podcast. Dr Daniel J. GuerraReferences ACS Chem. Biol. 2017, 12, 4, 958–968 Nat Rev Immunol. 2016 Apr; 16(4): 234–246 Guerra, DJ. 2024. Immuno-Biochemistry Lectures Vivaldi, A. 1705. Trio Sonata in D minor, RV 63 https://youtu.be/kPpaeW3DObU?si=nfJmUWlmiK8BZXxD Albinoni , T. 1708. Adagio in G Minor https://youtu.be/z6WOfH2kV00?si=Mf7_6JwuLETu7YEC Scarlotti, D. 1720. Fandango in D Minor https://youtu.be/QQbW75y3P9g?si=MODaHGMa-MSP5Nld 2024-05-2953 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry II. Authentic Biochemistry Podcast. B cell Biochemistry c4. Dr Daniel J. Guerra 27.5.24.References Guerra, DJ. 2024. Immunology Lectures (archives). Pisendel, JG. 1720. : Concerto in E-flat major or Violin, Strings & B.c Jun P I.3 https://youtu.be/SZI2IgOOSPU?si=8xNIyvzxPnkV2zlK Biber, HI. 1676. Passacaglia. G- minor, C.105 https://youtu.be/sgcR183f8gA?si=vYnlxQJDq8LgG_B4 2024-05-2740 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry. T cell Membranes Coda VII. C.22 Dr Daniel J. Guerra. Authentic Biochemistry 13.5.24 Cancers (Basel). 2023 Nov; 15(21): 5177 GUERRA, DANIEL J.(2022)CYTOEPIGENETICS: DIALECTICAL REVIEW OF A SUBCELLULAR ENDO-MEMBRANOUS COORDINATION OF GENE EXPRESSION AND CELLULAR FATE. Journal of Disease and Global Health, 15 (3). pp. 22-47. ISSN 2454-1842 McCartney-Lennon. 1968 "Martha My Dear." https://youtu.be/RXawa90YU2s?si=_CgaG0yOdbpcflYr2024-05-1446 minAuthentic BiochemistryAuthentic BiochemistryImmune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.10. Immune cell membrane glycosphingolipids. Dr. Daniel J. Guerra Authentic Biochemistry 23.4.24.References Guerra, D. 2023-24 lipid lectures J Oleo Sci. 2011; 60(10): 537–544. Gregorian Chants: 1100 AD. Beata es Virgo Maria https://youtu.be/rMlWhAh2Zvc?si=B3XqzCsQYef_ee6t Schubert, F. 1822. Schubert | Mass No. 5 in A flat major D 678 https://youtu.be/Yl5YF3PeUeI?si=AP9U_WHULnv3ItWi2024-04-2429 minAuthentic BiochemistryAuthentic BiochemistryBiochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry PodcastRefernces Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies. Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP. https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip- Schmelzer, JH 1664. Violin Sonatas, "Romanesca". https://youtu.be/fB8G39y1uCA?si=hzGCK2Qq6TtIubAh2024-04-0529 minAuthentic BiochemistryAuthentic BiochemistryPrimer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast ProductionsDr Guerra lecture notes2023-07-0930 minAuthentic BiochemistryAuthentic BiochemistryPhotosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productionsGuerra: Plant biochemistry Lectures2023-07-0629 minAuthentic BiochemistryAuthentic BiochemistryGraduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437. 2023-05-2429 minAuthentic BiochemistryAuthentic BiochemistrySpecial Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.Reference Dr Guerra: Graduate Biochemistry lecture material.2023-05-2029 minAuthentic BiochemistryAuthentic BiochemistryImmunoEpigeneticsX. Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic BiochemistryReferences J Cancer Res Clin Oncol. 2018; 144(6): 1065–1077 Nature Reviews Drug Discovery. Sep2014, Vol. 13 Issue 9, p673-691 Anal Cell Pathol (Amst). 2018; 2018: 787.1814 The Journal of Biological Chemistry 16/2/2018 293: 2422-2437. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message2022-12-3129 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic BiochemistryReferences Dr. Guerra lecture materials Progress in Lipid Research Volume 74, April 2019, Pages 145-159 2022-12-3129 minAuthentic BiochemistryAuthentic BiochemistryMembarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry PodcastReferences Timaeus, Plato Dr Guerra's thoughts and lectures N Engl J Med 2005;353:604-152022-11-2329 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry72. DHEA and the steroidogenic pathways as biochemical prolegomena to logical judgments. Dr. Daniel J. Guerra.29.10.22b.Authentic BiochemistryReferences Dr Guerra's lipid biochemistry lectures Int. J. Mol. Sci. 2019, 20, 4660; doi:10.3390/ijms201946602022-10-3029 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry PodcastReferences Dr. Guerra's lecture notes Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8.2022-10-1829 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic BiochemistryAl-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1 Dr Guerra Membrane lipid lectures2022-10-1529 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.References Dr Guerra's membrane lipid lectures Neuron 2015. Volume 85, Issue 4.Pages 695–7022022-10-0429 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic BiochemistryReferewnce Guerra basics lecture2022-10-0129 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic BiochemistryReferences Dr Guerra Tumor lectures Nature Reviews Endocrinology 2020.volume 16, pages224–233 J Neurochem. 2006 Nov;99(4):1237-50. doi: 10.1111/j.1471-4159 2022-09-2327 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022.References  Dr Guerra's Lecture notes2022-09-1729 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22References Dr Guerra's lipid and membranes lectures Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014.Volume 1841, Issue 9,  Pages 1241-1246 Onco Targets Ther. 2017;10:5491-55242022-09-1430 minBitácora de GuerraBitácora de GuerraTráilerHola soy Daniel Guerra, a lo largo de mi vida las preguntas del por qué me tocó a mi ser así, del por qué tengo esta discapacidad o del por qué nací con acondroplasia (enanismo vulgarmente), se han vuelto constantes en mi vida… En Bitácora de Guerra te daré las respuestas a esta pregunta que me he hecho a lo largo de mis 45 años de vida, desde por qué me considero una persona “normal” hasta cómo he cumplido todos mis sueños (esposa, hijo, trabajo, amigos, etc)…  Cambiando la pregun...2022-09-0401 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XXXXII. Basic Electrobiochemistry of Biological Membranes. Dr Daniel J. Guerra. 24.8.22b Authentic Biochemistry Podcast Audio Lectures.References Dr Guerra's membrane biochemistry/electrophyiology lectures2022-08-2529 minAuthentic BiochemistryAuthentic Biochemistrymembrane Biochemistry XXXXI. A priori Synthesis of Sex-linked Biochemical Dimorphism and Canonical Membrane Event Ontology. Dr. Daniel J. Guerra. 24.8.22.Authentic Biochemistry Podcast.References Dr Guerra's lecture marginalia2022-08-2429 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XXXI. Corticotropin Releasing Factor and "Fear" Neurobiochemical Correlates in the CNS. Dr Daniel J. Guerra. 9Aug2022. Authentic Biochemistry PodcastReferences Dr Guerra's neuroscience lectures Neurosci BiobehavRev. 2019 Aug; 103: 50–592022-08-1030 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XXIX. Final discussions on serum albumin and membrane disruption mediated inflammatory modulation. Dr. Daniel J. Guerra. 7bAug22.Authentic Biochemistry.References Dr Guerra's lipid lectures Int J Mol Sci. 2019 Oct; 20(19): 4860 JNCVolume109, Issue3May 2009 Pages 694-7052022-08-0829 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XXVII. Traumatic Brain Injury and Ischaemic Stroke associated neuroinflammation is mediated through membrane caveolae. Dr Daniel J. Guerra.3Aug22. Authentic Biochemistry.References Dr. Guerra's: membrane lectures J Clin Med. 2021 Sep; 10(17): 3795 J Neuroinflammation. 2016; 13: 264.2022-08-0429 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XXVI. Lipid molecular structures and membrane morphology impacting biological activity. Dr Daniel J. Guerra. 01August2022. Authentic Biochemistry Podcast Productions.References Dr Guerra's lipid lecture archive2022-08-0229 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry XIV. Apoptosis and Necroptosis review. Dr. Daniel J. Guerra. 8 July 2022. Authentic Biochemistry PodcastReferences Dr Guerra's notes Oncogene. 2009 Sep 3;28(35):3097-110 Mol Cell Biol. 2005 Aug;25(15):6363-79 J Neuroinflammation. 2019; 16: 236.2022-07-0926 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry X. Dialectical Event Ontologies and the Complexity of Biological Systems. Dr. Daniel; J.Guerra 2 July 2022 Authentic BiochemistryReferences Dr Guerra's ideas 2022-07-0229 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry VIII. The basics of lipid membranes. Part 1. Dr Daniel J. Guerra. Authentic Biochemistry Podacst Production. 28.6.22References Dr Guerra's lectures PNAS September 28, 2010 107 (39) 16783-16787;2022-06-2929 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic BiochemistryReferences Dr Guerra's notes Sci Signal. 2016 Aug 23; 9(442): ra83 Front. Pharmacol., 24 April 2019 2022-06-2129 minAuthentic BiochemistryAuthentic BiochemistryCytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022References Dr Guerra's notes Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:436 JAMA. 2008;299(11):1345-13502022-06-0629 minAuthentic BiochemistryAuthentic BiochemistryCytoEpigenetics I. Introduction. Dr. Daniel J. Guerra . 22.4.22. Authentic Biochemistry Podcast ProductionsReferences Introductory remarks from Guerra's research Trends in Cell Biology, 2017-06-01, Volume 27, Issue 6, Pages 453-463.2022-04-2329 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXXV. Rodent model adipose mitochondrial respiratory contribution to obesity control involves a selenium protein and UCP1 sulfenylation. Dr Daniel J. Guerra. Authentic Biochemistry.18.4.22References Dr. Guerra Lipid and Intermediary Metabolism lectures Cell Reports 2022. 38, 110566 PNAS July 24, 2017 | 114 (32) 8649-8654 2022-04-1929 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22References Dr. Guerra's notes2022-04-1729 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXX. The pleitropic roles of free fatty acids and PPAR's as mediating insulin sensitivity, intermediary metabolism and the inflammatory response in T2D.Dr Daniel J. Guerra 13.4.22. AuthenticReferences Dr. Guerra lecture notes Prog Neurobiol. 2018 Apr-May; 163-164: 27–58. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:28–40 2022-04-1329 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXVII. Dyslipidaemia and the Insulin Resistance Axis. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast 7April2022.References Dr. Guerra's lectures Curr Med Chem. 2017;24(17):1827-1852 Cancer Res. 2018 Apr 1; 78(7): 1713–17252022-04-0829 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXIV. Sphingosine 1-phosphate targeting and the abalation of primary breast cancer metastasis: IL6 mediated tumorigenesis blockade? Dr Daniel J. Guerra 01April2022. Authentic BbiochemistryReferences Dr Guerra's notes Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042 2022-04-0229 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXIII. Obesity-associated IL6 and sphingosine 1-phosphate are linked to breast cancer.Dr. Daniel J. Guerra. 31 March 2022. Authentic BiochemstryReferences Dr. Guerra's  lecture notes Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415. 2022-04-0129 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XXII. Obesity and cancer are linked by inflammation and dyslipidaemia. Dr Daniel J. Guerra. 30.3.22 Authentic BiochemistryReferences Dr Guerra's lectures notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.2022-03-3129 minAuthentic BiochemistryAuthentic BiochemistryDiabetes XIV. The Neuropsychiatric/Neurodegeneration axis from Sphingomyelin Degeneration to Increased Inflammation. Dr. Daniel J. Guerra. 17.3.22. Authentic Biochemistry ProductionsReferences Dr Guerra Lecture archives Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021.Volume7, Issue1 e12217 EBioMedicine. 2015 Dec; 2(12): 1888–19042022-03-1729 minAuthentic BiochemistryAuthentic BiochemistryDiabetes IX. The role of peroxisomes in ether-linked lipid biosynthesis. Dr.Daniel J. Guerra. 07March2022. Authentic Biochemistry Podcast productionReferences Dr Guerra's lecture material2022-03-0829 minAuthentic BiochemistryAuthentic BiochemistryDiabetesVIII. Subcellular organization and the role of lipid metabolism in mitochondria and peroxisomes. Dr Daniel J. Guerra. 05March22. Authentic BiochemistryFrom Dr. Guerra's lecture archives2022-03-0530 minAuthentic BiochemistryAuthentic BiochemistryDiabetes IV. Pancreatic Exocrine Insufficiency in Types I, II, and III Diabetes Mellitus. Dr DAniel J. Guerra. 28.2.22. Authentic BiochemistryReferences Dr. Guerra Lecture notes Int J Endocrinol. 2015; 5956492022-03-0129 minAuthentic BiochemistryAuthentic BiochemistryType 2 Diabetes I. Initial lecture describing insulin resistance and dyslipidaemia. Dr Daniel J. Guerra 22.2.22 Authentic Biochemistry Podcast.References Dr. Guerra lecture notes Reviews in Endocrine and Metabolic Disorders. 2020. 21: 631–643. J Lipid Res. 2015 Mar; 56(3): 588–598. 2022-02-2329 minAuthentic BiochemistryAuthentic BiochemistryFatty Acids IX. The Monounsaturated fatty acid inhibition of ferroptosis and apoptosis leads to cancer progression. Pharmacotherapeutic Considerations. Dr Daniel J. Guerra. 17.2.22 Authentic Biochem.References Dr. Guerra's notes-unpublished Cancer Res. 2019 Oct 15; 79(20): 5355–5366.2022-02-1830 minAuthentic BiochemistryAuthentic BiochemistryFatty Acids II. Obesity and lipotoxicity. Dr Daniel J. Guerra. Authentic Biochemistry 04. February 2022References Dr. Guerra's lecture notes Int J Mol Sci. 2021 Jan; 22(1): 3302022-02-0529 minAuthentic BiochemistryAuthentic BiochemistryFatty Acids I. Dr. Daniel J. Guerra. 03.02.22. Authentic Biochemistry PodcastReferences Dr. Guerra's lecture notes Int J Mol Sci. 2021 Jan; 22(1): 330. 2022-02-0429 minAuthentic BiochemistryAuthentic BiochemistryAnabolism V. The nucleic acids. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast.28.01.22References Dr. Guerra's lecture notes2022-01-2929 minAuthentic BiochemistryAuthentic BiochemistryAnabolism IV. Cholesterologenesis. Dr Daniel J. Guerra. 26 January 2022. Authentic Biochemistry PodcastFrom Dr. Guerra's lecture notes2022-01-2730 minAuthentic BiochemistryAuthentic BiochemistryAnabolism III. Fatty acid synthesis de novo . Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Productions. 25.01.22References Dr. Guerra lecture notes2022-01-2629 minderppunk 3Speak Podcastderppunk 3Speak PodcastNo quiero ir a la guerra - Flema | Acoustic cover by @derppunkhttps://3speak.tv/watch?v=derppunk/rkhrsyot Hola amigos, hoy les traigo otro cover de la banda de punk argentina Flema es una canción cuya letra siempre me ha gustado asi que espero que la disfruten, sin mas que agregar aquí les dejo el video. Hello friends, today I bring you another cover of the Argentine punk band Flema is a song whose lyrics I have always liked so I hope you enjoy it, without more than adding here I leave the video. Imagen de mi propiedad editada en canva/Im...2021-11-2000 minAuthentic BiochemistryAuthentic BiochemistryMembrane Biochemistry Primer and Introduction to Aging. Dr. Daniel J. Guerra. Authentic Biochemistry Productions. 13.9.21Dr. Guerra introduces a primer on membrane biochemistry in preparation for a florid analysis of autophagy and the various forms of programmed cell death linked to the aging human. References Cell Discovery volume 7, Article number: 4 (2021) 2021-09-1329 minAuthentic BiochemistryAuthentic BiochemistryPharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.A.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support!2021-06-1029 minPensemos lo InternacionalPensemos lo InternacionalIX EL Gran Suicidio de la Razón: La Gran Guerra - inicios¿Cómo es posible que la civilización hubiera llegado a aquello? ¿Porque habían muerto tantos millones inútilmente? Los caprichos, los miedos, las frustraciones y las ansias de revanchismo llevaron a esa sociedad tan civilizada a dejarse llevar por sus instintos. Apocalipsis: La Primera Guerra Mundial - 2. Temor en https://www.youtube.com/watch?v=ZccIaqLY1K0 La Guerra de Trincheras, la Guerra Química, la Guerra aérea, la llegada del bombardero en 50 Cosas que hay que saber sobre la Guerra de Robin Croos  La Primera Guerra Mundial en Guerras...2021-05-0123 minPensemos lo InternacionalPensemos lo InternacionalEl Gran suicidio de la razón: La Gran Guerra - Origenes¿Cómo el mundo llegaría a desatar la Primera Guerra Mundial? En este episodio, el primero de nuestro especial ahondaremos los contextos políticos y sociales que le darían forma a este gran Suicidio de la razón.  La Primera Guerra Mundial puso fin a un largo período de Paz sostenida en Europa: una época en la que se hablaba confiadamente de prosperidad, de progreso y de esperanza. Y sin embargo en 1914 el continente se lanzó de cabeza a un conflicto catastrófico, que mató a millones de personas, desangró las economías nacionales, derrumbo los imperios...2021-04-2424 minAuthentic BiochemistryAuthentic BiochemistryCondensed Bioenergetics : Dr Guerra Drives the Electron Transport Chain via Standard Oxidation Reduction Potentials. 21.3.21Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra Authentic Biochemistry Studios 21.3.212021-03-2229 minAuthentic BiochemistryAuthentic BiochemistryCell Cycle kinase inhibition may improve healthy cardiac aging while promoting global tumorigenesis. Authentic Biochemistry 10Feb2021 by Dr Guerra.*Oncogenesis eventuates genetic mutation to epigenetic gene expression mechanisms with molecular signatures either inappropriately proscribed, incorrectly prescribed upon writing as  dangerous and deleterious, or erasure;  leaving a corrupted  chromatin result.  *Tumor cells obtain proliferative autonomy, autophagous –self-maintenance in growth and signaling, neovascularization for nutrient and oxygen supply, and resistance to anti-proliferative and apoptotic stimuli  *In resting cells, the cell cycle is strictly managed by a set of regulatory proteins that control the various cell cycle checkpoints and this will become dysfunction during the early transforming stage of the tumorigenesis via the unregulated dismantling of tumor suppres...2021-02-1129 minAuthentic BiochemistryAuthentic BiochemistryThe Corticotropin Releasing Factor and the Somatosensory Catecholamine Circuit in ExtraDimensional (attentional) Shifting. Dr Guerra 20 Jan 2021.AB.Adaptation to stress-such as the fear response obtains dopaminergic input to striatum and prefrontal cortex and  is thought to signal unexpected events and facilitate a shift in attention to promote new learning within the contralateral primary somatosensory cortex (SI) which has been associated with the agentic categories of both the quality and quantity of thought event ontology. This process works in conjunction with  the bilateral secondary somatosensory cortex (SII) process  involved in executive  decision making. Where stimulated, the primary sensory motor-neuronal process  is integrated with novel extra-dimensional learning . Recall that this fear stress response can lose functional valenc...2021-01-2028 minAuthentic BiochemistryAuthentic BiochemistryAn Immunological Distinction between Senescence linked Secretory Phenotypes: SASP vs. Midas. Dr. Dan Guerra. Authentic Biochemistry 16 Jan 2021Non-uniform ageing is a major associative risk factor for cancer and degenerative diseases and mitochondrial dysfunction is linked to cellular senescence in association with cell cycle arrest, telomerase decline and nucleic acid/lipid/protein oxidation. Indeed, mitochondrial dysfunction comprises a distinct type of cellular senescence; mitochondrial SIRT3 or SIRT5, can induce Mitochondrial Dysfunction Associated-Senescence (MiDAS) Senescence is a chronological and pathophysiological sequenced event response that restricts mitotic division and thus aberrant proliferation of damaged, infected and/or tumor inducing cells. Because these cells are senescent and exhibit low anabolic currency to present self-produced antigen epitopes as displayed...2021-01-1729 minAuthentic BiochemistryAuthentic BiochemistryT cell metabolic Dialectics : deriving bioenergetic supremecy from glycolysis through fatty acid and lipid synthesis to ultimate fatty acid oxidation and ATP generation. Dr Daniel J. GuerraAuthentic Biochemistry Podcast 29 December 2020 Daniel J. Guerra Ph.D. •All scientific inquiry should start with dialectical method that uses the current knowledge base to generate various specific Theses and then follow each with the counter-argument by employing the Square of Opposition thus producing Anti-theses and then, making the third movement, which allows for a Synthesis that has the flavor of rejection, acceptance or indifference. *Downstream of co-stimulation and PI3K-AKT, the mammalian target of Rapamycin (mTOR) kinase pathway integrates multiple signals and regulates anabolic metabolic reprogramming in T cells exiting qu...2020-12-3029 minAuthentic BiochemistryAuthentic BiochemistryFrom Glucose to Triacylglycerol in the developing T lymphocyte. Dr Daniel J. Guerra. Authentic Biochemistry 21 December 2020In this episode Dr Guerra provides a concise description of  T lymphocytic fatty acid synthesis from glucose via cytosolic glycolysis,  mitochondrialpyruvate dehydrogenase, pyruvate carboxylase, and citrate synthase and a return to the cytosol for ATP citrate lyase and the homodimeric polyprotein complex FAS to generate palmitoyl-ACP. This ability of  antigen-MHC Antigen Presenting Cell  TCR - activated T lymphocytes to prepare for massive cytokine and chemokine expression requires a biochemical poise to use newly synthesized intracellular triacylglycerol to drive cellular exapnsion and effector-mediated immune responses. Subscribe and Donate! MERRY CHRISTMAS!!!2020-12-2329 minAuthentic BiochemistryAuthentic BiochemistryThe Misguided Linkage of Potentially Ablating Aging -Associated Metabolic Syndrome by tracking NAD+ serum levels. Dr. Daniel Guerra. 17 December 2020.Metabolic syndrome  (MetSyn)is a dyslipidaemic chronic and aging  linked sedentary life-style constellation of disease presentations including metabolic disorganization, prodromal Type 2 diabetes and a prominent connection to hypertension-most prominently associated with over-eating and obesity. MetSyn is often  prolegomena to middle-age onset CVD, cancer and neurodegeneration. High caloric density soluble carbohydrate nutrition, lack of fasting and the species-specific metabolic inability to convert fatty acids into glucose via gluconeogenesis, provide a pathobiochemical poise toward MetSyn. As Nicotinamide Adenine Dinucleotide (NAD+) levels decline with age and obesity a potential suppression of NAD (H)-dependent enzymes in oxidative phosphorylation, the TCA cyc...2020-12-1729 minAuthentic BiochemistryAuthentic BiochemistryFrom Bioenergetics to Cardiac Function and Thymocyte differentiation in the Aging Population. Dr. Daniel J. Guerra 02 December 2020.In today's lecture, Dr Guerra explains how subclinical hypothyroidism obtains increased serum thyrotropin (thyroid stimulating hormone, TSH) with flat levels of of free thyroxin (T4) and biologically active free triiodothyronine (T3) in the elderly;β1 adrenergic receptors, sodium/potassium ATPase, voltage-gated potassium channels, malic enzyme and atrial and brain natriuretic factor all respond favourably to thyroxin and hese proteins form the primary architecture of the cardiomyocyte and determine contractile strength. ATP drives muscle contraction/relaxation thus active  mitochondrial nadh  oxidation is essential for healthy aging. Ketone and free fatty acid oxidation decreases with aging while glucose oxidation reciprocally increases while thy...2020-12-0329 minAuthentic BiochemistryAuthentic BiochemistryDr. Guerra herds the Hippo Pathway into T lymphocyte mediated autoimmune disease and cancer in the aging human Authentic Biochemistry 16 November 2020On this 16th of November Authentic Biochemistry Podcast episode acknowledging my sister Carol's birthday, I explain the MST- kinase mediated transcription factor HIPPO pathway and its potentially gravid linkage to aging associated lymphocyte-informed  autoimmune disease, cancer and neurodegeneration. Published by Dr.. Daniel J. Guerra. 2020 References Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Pharmacological Research Volume 143, May 2019, Pages 151-165 Trends in Cancer, May 2019, Vol. 5, No. 5297-307 Nature Reviews Rheumatology volume 13, page389(2017) Adv Immunol . 2019;144:87-1192020-11-1629 minAuthentic BiochemistryAuthentic BiochemistryTranscription Factor NFil3 tracks the circadian clock to microbiome linked immune cascade in the gut. Dr. Daniel J. Guerra 09 Nov. 2020NFIL3 is a critical transcription factor  immunologically linking the microbiome to the  circadian clock and lipid metabolism where the  Innate Lymphoid Cell subtype 3 and dendritic cells may stipulate the intestinal microfloral  associated  epithelial temporal chronicity. Subscribe to my Podcast and donate! Published by Dr Daniel J Guerra, Authentic Biochemistry 09 November 2020 Reference: Science. 2017 Sep 1; 357(6354): 912–916.2020-11-1029 minAuthentic BiochemistryAuthentic BiochemistryThe Circadian clock and the Acquired Immune Response coordinate at the event of transcription factor mediated aging phenotype. Dr Daniel J. GuerraDr. Guerra hybridizes multiple strands of published biochemical research to obtain an event ontology for potentiating factors leading to the aging human pathophysio9logical phenotype.  In this lecture  I include the following detail: 1. Nuclear factor interleukin 3 (NFIL3, also known as E4-binding protein 4, E4BP4) is a repressor of numerous genes. where an N-terminal domain directly binds to its response element, while the C-terminal region is responsible for homo- or heterodimerization to induce a temporally synchronized geometric configuration obtaining as a transcriptional repression domain 2. NFIL3 represses genes by recruiting histone deacetylase 2 and G9a...2020-10-3029 minAuthentic BiochemistryAuthentic BiochemistryDr. Daniel Guerra presents Immuno Diaeventontological Framing of the Aging Human IV: SASP to cGAS via MelatoninDr.  Guerra temporally organizes the lecture series toward the dialectical event by mindfully schematizing the SASP , the triad of DNA Damage Repair (DDR)responses, transcriptionally activated  pro-inflammatory cytokine mediated  inflammation, and the pineal-endocrine hormone melatonin circadian clock manifestations  in the biochemistry and physiology of the aging human. Please SUBSCRIBE! and when you can PLEASE DONATE to your favorite authentic biochemist so he can continue to provide with august research science interrogation and analysis. 2020-10-0829 minAuthentic BiochemistryAuthentic BiochemistryDr. Guerra finds that the tumor-promoting and suppressing biochemical phenotypes of senescence are phenomenologically contrarion and thus physiologically compatibleLipids, proteins carbohydrates  and nucleotides-may function within  an inflammatory and secretory modality. Thus, the SASP-Senescence-Associated Secretory Phenotype might deliver apoptosis, necroptosis, autophagy, oncogenesis or an extended  senescence sequalae. An Authentic Biochemistry audio lecture podcast by  Dr. Daniel J. Guerra. 04 October 2020. Please SUBSCRIBE , check out my video lectures ( https://www.youtube.com/channel/UCcEoA2N9WSlNvDk1BtuznfQ?view_as=subscriber) and donate! https://podbay.fm/p/authentic-biochemistry Grazie! Dr. Guerra Nature Reviews | Cancer Reviews 19 | AUGUST 2019 :pp. 439 Nature Communications Vol. 9, Article number: 1228 (2018) doi:10.1038/s41467-018...2020-10-0429 minAuthentic BiochemistryAuthentic BiochemistryThe Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan GuerraDr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes  and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of prenyl and acyl lipogenesis, Published 18 August 2020 by Dr Daniel J. Guerra.  Review of: Front. Pharmacol., 17 March 2020.  https://doi.org/10.3389/fphar.2020.00265 2020-08-1928 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020The master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating  AMPK may reduce glioblastoma progression and this observation helps to advance a theory for healthy longevity that requires a reduction in anabolism. By Dr Daniel J. Guerra. Published 01 August 20202020-08-0129 minDescobrindo Que Nada SeiDescobrindo Que Nada SeiA Primeira Guerra Mundial em 10 MINUTOS!!A 1 Guerra Mundial ficou conhecida como a guerra para acabar com todas as guerras. Sabemos que não foi bem assim. Foi uma guerra monstruosa, com várias frentes de batalhas, milhões de mortos e mudou a face do mundo. Conheça hoje um dos conflitos mais brutais da humanidade, a 1 Guerra Mundial. Confiram nesse Podcast, um pequeno resumo sobre os principais acontecimentos da primeira guerra mundial. Instagram: daniels_sbrito --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app2020-07-1610 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra Presents: Serine Protease Inhibitor Biochemistry in Human Health and Disease I. 25 June 2020In this  session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example,  the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis  which is an essential  hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling  systemic wound repair, and the inflammatory response as linked to cytokine mediated immune responses and circulating t-PA mediated cardiovascular function. Dr Guerra also mentioned that he has established a PATREON site:   https://www.patreon.com/user?u=37615512&fan_landing=true&fbclid=IwAR0L8ADIhtIgZM_WtkJejz_x-3hAdzr39mrvoZxd...2020-06-2628 minAuthentic BiochemistryAuthentic BiochemistryNutritional biochemistry and the obesogenic induction of insulin resistance and type-2 diabetes. Dr Daniel J. Guerra. 25 May 2020Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b.2020-05-2629 minAuthentic BiochemistryAuthentic BiochemistryGeneral Hormone Lectures II. The Hypothalamic Pituitary Axis. Dr Daniel Guerra. 05 May 2020.Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.  2020-05-0528 minAuthentic BiochemistryAuthentic BiochemistryGeneral Human Hormone Physiology and Biochemistry Lecture I. Published by Dr Daniel J. Guerra. 04 May 2020Dr Guerra gives a fast paced knowledge-laden series of lectures on the medical physiological and biochemical features of human hormonal signaling. Lecture I Introduction and Classification. Published on line 04 May 20202020-05-0427 minAuthentic BiochemistryAuthentic BiochemistryChapter V Immuno Endocrinology of Disease Dr Dan Guerra Authentic Biochemistry Podcast 27 April 2020Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus  aureus. Dr Daniel J Guerra published on 27 April 2020.2020-04-2729 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra presents today's podcast: Lipid –Associated Pathobiochemistry III. March 3 2020Today's podcast establishes the significance of sphingolipids in maintaining normal biochemical and physiological homeostasis by detailing membrane organization of pathways and linkage to cell fate and the potential for pathobiology in human disease. Published 03 March 2020 by Daniel J. Guerra, PhD2020-03-0328 minAuthentic BiochemistryAuthentic BiochemistryPart III. Autoimmune Disease : essential background and cellular dynamics. Dr Dan Guerra19 January 2020. This is a podcast delivering Part 3 in my new arc describing the significance of biochemical and epigenetic reprogramming of T lymphocytes in human autoimmune disease. Parts 1&2 of this series are found as video lectures at https://www.youtube.com/playlist?list=UUcEoA2N9WSlNvDk1BtuznfQ. Dr Daniel J. Guerra of VerEvMed and Authentic Biochemistry. 2020-01-2027 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra provides an in-depth interrogation of lipid metabolism of omega three fatty acids and their complex roles in controlling inflammation.Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains  regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid.   04 Sept 2019.2019-09-0527 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcription while activating Th1 and Th2Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3. This is an important contribution to the T lymphocyte literature as it points to the proximal and distal modulation of T cell lineage differentiation, thus focusing attention to potential pharmacotherapeutic and immunoepigenetic mechanisms to control inflammation in diseases s...2019-08-1728 minAuthentic BiochemistryAuthentic BiochemistryDr Guerra continues : Glutamate induced ferroptosis involves lipid peroxidation and ceramide production leading to an inflammatory response in neurodegenerationDr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B2019-03-2629 minAuthentic BiochemistryAuthentic BiochemistryDr Daniel Guerra introduces a novel PCD pathway- ferroptosis- that is linked to excitotoxicity and lipid peroxidation leading to neurodegeneration. Part IThis is the first part of a diaeventontological framing of lipid peroxidative mechanisms for CNS neurodegeneration. Dr Guerra describes recent published research  (JLR 2018 .59:312pp.) and develops some of the key elements of the ferroptosis programmed cell death mechanism leading to  oligodendrocyte and neuronal degeneration that will participate in a grander understanding of injury-induced  and idiotypic age-associated disease in the CNS. 25 March 2019.2019-03-2526 minAuthentic BiochemistryAuthentic BiochemistryAuthentic Biochemistry #3. Dr Guerra verifies the evidence to a future biochemical prolegomena for Alzhiemer's DiseaseIn this podcast, Dr Daniel Guerra of Authentic Biochemistry and VerEvMed endeavours to examine the  bioenergetic and pro-inflammatory prodromal  patho-biochemistry of age-onset Alzheimer's Disease using his diaeventontological toolkit.2019-03-1027 min