Shows
Authentic BiochemistryImmunological Pathobiochemistry XIII Authentic Biochemistry Podcast Dr, Daniel J Guerra 09AUG25ReferencesGuerra, DJ. 2025. Unpublished LecturesGuerra, DJ. 2022. JODAGH, 15(3): 22-47Tessarini, C.1729-1735. Violin Sonatashttps://music.youtube.com/playlist?list=OLAK5uy_lSpm8ue9AU-rkq8lbukU7uUK7LN7THx7Y&si=V_go09yAat6cv9O6JP Jones, Plant,Paige, 1975. "In the Light"https://music.youtube.com/watch?v=pNo1nS_JV5k&si=bfUBlfcL4Wt5qIOyLenon/McCartney. 1970. "Let It Be"...
2025-08-101h 09
Authentic BiochemistryA priori Metabolic Architectonics. XVIII. 10FEB25 Authentic Biochemistry Podcast. Dr Daniel J. Guerra.ReferencesCell Prolif. 2021 Dec 22;55(1):e13167Front. Oncol 2017 26 November Guerra, DJ. 2025. Unpublished LecturesBeethoven LV. 1804. Symphony 3. IN E. Major Op. 55. "Eroica"https://music.youtube.com/watch?v=fhHcty9OM-0&si=3pkScsgJBGiuyMhJMiller and Winwood 1968. "Medicated Goo" Traffic•https://open.spotify.com/track/3OD2BlIAkr1DkSe94sKIoI?si=46125a00f2474ac5Hayward and Thomas 1969. " Are you sitting comfortably" Moody Blues On the Threshold of a Dream lp•https://open.spotify.com/track/5E8djSHnmvGSnupEF6t35w?si=55b70751bcd04bf7
2025-02-1153 min
Authentic BiochemistryA priori Metabolic Architectonics. XVI. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra 05FEB25References
Biochimica et BiophysicaActa (BBA) - Biomembranes2016.
Volume 1858, Issue 11, November 2016, Pages 2681-2688.
Cells.2020 Feb 5;9(2).
Nature 2024. volume 633, pages451–458.
Guerra, DJ 2025. Unpublished lectures.
Anderson, I 1969."We Used to Know" on Stand Up [lp]. Jethro Tull
https://open.spotify.com/track/5bSSkaqVo0qsOmtYOcPpp3?si=f6373f78d5f2498d
Hayward, J. 1969. I never Thought Id Live to be a Hundred" Moody Blues. ToCC lp.
https://open.spotify.com/track/0gp2N9ibCfQiaGClFconQt?si=f402ff5690c34109
Mozart. WA. 1780's Complete Piano Sonatas.
ht...
2025-02-061h 23
Authentic BiochemistryA priori Metabolic Architectonics XV. Authentic Biochemistry Podcast. Dr.Daniel J. Guerra. 02FEB25References
Guerra, DJ.2025. Biochemistry Lectures Unpublished
Nature 2024. 633:451.August
Howard, B. 1954. "Fly Me to the Moon" Sinatra
https://open.spotify.com/track/7FXj7Qg3YorUxdrzvrcY25?si=1708dba3cda74072
Van Heusen and Cahn 1964. "My Kind of Town" Sinatra
https://open.spotify.com/track/6jnmiFauoWEtg5yXLJYzzF?si=250efc2c6bd543d2
Hayward, J.1967. "Nights in white Satin" Moody Blues DoFP lp.
https://open.spotify.com/track/6L5BZEcZmD6RBJnimzlyKr?si=d4b9bac9a457434a
2025-02-0347 min
Authentic BiochemistryA priori Metabolic Architectonics XI. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 25JAN25.References
Current Opinion in Biotechnology2023. 84, December .103011
Guerra, DJ. 2025. Biochemistry Lectures unpublished
Anderson and Howe.1971. "Roundabout" YES. Fragile Lp.
https://youtu.be/QOrrNM4md8c
Winwood, S. 1969. "Sea of Joy" Blind Faith lp
https://youtu.be/z7DVYnaH_oY
Bach, JS. 1730Violin Concerto in D minor BWV 1052R
https://youtu.be/bZFOhkGGr8A
2025-01-261h 10
Authentic BiochemistryA Priori Metabolic Architectonics X. Authentic biochemistry Podcast. Dr. Daniel J. Guerra. 23Jan25References
Nat Metab. 2023 Aug 23;5(8):1275–1289.
Guerra, DJ. 2025. Lecture material unpublished.
Mozart, WA. 1782. Symphony 35 in D Major. K385. Haffner.
https://www.youtube.com/watch?v=nz0cbSYrDLk
2025-01-241h 03
Authentic BiochemistryA priori Metabolic Architectonics IX. Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 19Jan25References
Guerra, DJ 2025 Unpublished Biochemistry Lectures
Slade/Mann/Rogers. 1975."Time is Right"
https://www.youtube.com/watch?v=jzJIej8h5q4
Bruce/Clapton/Brown. 1967. "Sunshine of Your Love" Live Cream Vol II lp.
https://www.youtube.com/watch?v=tVCeZvusHCU
Joel, B. 1978. "Until The Night" 52nd Street lp
https://www.youtube.com/watch?v=MuV-zEqB2QQ
Schmelzer. J. 1683. Violin Sonatas. Romanesca
https://www.youtube.com/watch?v=fB8G39y1uCA
2025-01-2047 min
Authentic BiochemistryA priori Metabolic Architectonics VIII. AUthentic Biochemistry Podcast . Dr. Daniel J. Guerra. 18January25References
Guerra, DJ 2025. Biochemistry lectures unpublished.
Discov Immunol . 2024 Nov 19;3(1):kyae016
Lennon/McCartney. 1963 "Thank You Girl" Beatles
https://www.youtube.com/watch?v=cGka0tXQYAI&list=RDcGka0tXQYAI&start_radio=1
Lennon/McCartney. 1969 "Golden Slumbers/Carry that Weight/The end" Beatles on Abby Road .
https://www.youtube.com/watch?v=6qrDlRsARwk
Rossinni, G. 1829. "William Tell Overture"
https://www.youtube.com/watch?v=z7Tj2SzToHI
Schubert, F. 1823. Rosamunde Overture D.797.
https://www.youtube.com/watch?v=eweNfeaztoY
2025-01-191h 13
Authentic BiochemistryA priori Metabolic Architectonics VII. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra 16January25References
Discov. Immunol. 2024 Nov 19;3(1):kyae016.
Cell Reports 2015. 13, Issue 1p132-144October 06.
Guerra, DJ. 2025. Biochemistry Lecture Notes, unpublished
Rachmaninoff, S. 1900. Piano Concerto 2 in C minor. op.18.Khatia.
https://www.youtube.com/watch?v=tSvq_GnGfTI&t=761s
Kirwan, Danny 1971. "Woman of a Thousand Years" on Future Games lp.
https://youtu.be/DQYHFWGXeDk?si=sYVGCrCvilagi5rt
2025-01-1757 min
Authentic BiochemistryA priori Metabolic Architectonics V. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 10January25References
Guerra, Daniel J. 2024-2025. Biochemistry lectures and unpublished Metaphysics.
Front Endocrinol (Lausanne). 2020 Dec.3;11:587189
Int J Mol Sci. 2023 May 16;24(10):8811.
Lake, G. 1970."Just Take a Pebble" ELP.
https://open.spotify.com/track/3yTk0DOOIqz1MNDW2Bj9P9?si=954782df84764dc8
Hunter-Garcia. 1977.Terrapin station. Grateful Dead.
https://open.spotify.com/track/2gdTkM0hL9KQipAx6aUT6L?si=1b3a3d5afa34430d
Mozart. WA. 1787. "Eine Kleine Nachtmusik" Serenade 13 in G. Major K.525.and music by Grieg and Prokofiev.
https://open.spotify.com/album/5iAlyjqXMlO0JNaZ9jMjHF?si=7...
2025-01-111h 11
Authentic BiochemistryA priori Metabolic Architectonics IV. Dr. Daniel J. Guerra Authentic Biochemistry Podcast .09January 25References
Guerra, DJ. 2025. Biochemistry Lectures.
Int J Mol Sci. 2023 May 16;24(10):8811.
Front Endocrinol (Lausanne). 2020 Dec.3; 11:587189
Berry, Chuck. 1958. "Johnny B Goode". Dead. Winterland 71'
https://youtu.be/dWvdY-j0_Kw?si=HhKedcHgHhMOY3Di
Brahms, J. 1878. Violin Concerto. D Major. Op 77
https://youtu.be/9L6a-JJCCzw?si=mh8Q_4dKuPWvEfwB
2025-01-1057 min
Authentic BiochemistryA priori Metabolic Architectonics III. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 7Jan25References
Guerra, DJ 2025 Biochemistry Lectures
Front Endocrinol (Lausanne). 2020 Dec3;11:587189.
Annual Review of Food Science and Technology.2022. Volume 13:263-286.
Journal of Hepatology 2012 56, 704-713.
Nature Communications.2024. 15, Article number: 1879
Beethoven, LV. 1803.Triple Concerto in C Major. Op 56
https://youtu.be/pkXGtE8_cig?si=2WMWadCDhvcvfHJa
Schubert F. 1824. Quartet #14 in D Minor D.810.
https://youtu.be/CSdlrvC08lM?si=lNm3pxWK_hTCTLwa
Goffin and King. 1968. "I Wast Born to Follow". Byrds
https://youtu.be/PrU9iI2VxPE?si=3IrJ1FByg3Pp6-lh
2025-01-081h 08
Authentic BiochemistryA priori Metabolic Architectonics in Obesity and Hepatic Disease II. Authentic Biochemistry Podcast . Dr Daniel J. Guerra 06JAN25References
Guerra, DJ.2025. Biochemistry Notes
Cell Metabolism 2024. Issue 6P. Volume 36: 1371-1393.e7
Habershon, Ada R. in 1907. "Will the Circle be Unbroken" on Earl Scruggs Revue lp.
https://youtu.be/cslIdg2Q5oM?si=KgxebBDyyK1bncDX
Hayward, J. 1968"the Actor" Moody Blues.
https://youtu.be/sFHUJeTHznk?si=idGJ5N5WxMxgS453
2025-01-071h 11
Authentic BiochemistryA priori Metabolic Architectonics I. Dr. Daniel J. Guerra 04January 2025. Authentic Biochemistry Podcast.References
Guerra, DJ.2025. Biochemistry general lecture.
Immunol. Res. 2020. 68:28-38. J
J Vis Exp. 2013 Nov 22;(81):50966.
Anderson, I. 1969. "A New Day Yesterday" Jethro Tull [Stand Up. lp]
https://youtu.be/Kq5zTznlSJI?si=rJkLP28p3T4-F4Qw
Nestor, Armatrading. 1972. "Visionary Mountains" MMEB {Nightengales and Bombers.lp]
https://youtu.be/z1zzeAttCCc?si=7IRveShgMwTn0CJ8
Mozart,WA. 1783. String Quartet K 421 in D Minor
https://youtu.be/QLHDRzv2VzQ?si=sfhG07rO2ojQv-J-
2025-01-051h 01
Authentic BiochemistryEtOH IV. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra. 01January25References
Guerra, Daniel J. 2024 Biochemistry lecture archives
Cells.2019 Nov 12;8(11):1424
Front Cell Neurosci 2017 Feb1;11:14.
Neuropharmacology 2014.79, April : 1-9
Front Mol Neurosci. 2024 May 22;17:1389100.
Byrds. 1971. Byrdmaniax lp
https://youtu.be/SEBecV36esY?si=wtSnoWe-fAHZzbNv
Porter and Fletcher.1934 "Don't Fence Me In" Bing Crosby and Andrew Sisters (1945)
https://youtu.be/ILyuEtGrMwI?si=WpBi9KG9m7dzufW4
2025-01-021h 10
Authentic BiochemistryAuthentic Biochemistry Podcast . EtOH II. Dr. Daniel J. Guerra.29December24References
Guerra, DJ.2024. Biochemistry Lectures.
Cell Metab. 2019 Apr 2;29(4):856-870.
Alcohol, 2017-12-01, Volume 65:51-62
Hunter-Garcia 1970. "Ripple"
https://youtu.be/xofhZx9eWUQ?si=TvFBFagovrpvKdGj
Lennon-McCartney. 1966. "For No One"
https://youtu.be/sep5E3ssXLQ?si=ANvuJgO2wmg2IXFt
Kantner/Slick/Crosby 1970. "A Child is Coming"
https://youtu.be/1D0Qr7VxaMs?si=XPNnjdqN7O7Scm0j
Croce, J.1973. "It Doesn't Have to Be That Way"
https://youtu.be/Sxvd8NEd_C8?si=RtZ80hQvVPynfzhZ
Lamb, R. 1969. "...
2024-12-301h 01
Authentic BiochemistryAuthentic Biochemistry Podcast. Cell Surface Enzyme Kinetics VI. Dr Daniel J Guerra 21Nov.24.References
Molecules 2013, 18(8), 9278-9292
Nature Methods. 2019. volume 16, pages 815–829.
Guerra, DJ. 2024. Lectures
Valenti, D. 1970 "Dont Cry my Lady Love". Quicksilver Messenger Service.
https://youtu.be/JhiagyyNWg0?si=7r8uRlXKshqruVtu
Cantus Mariales .10th century AD.
https://open.spotify.com/album/0hJBZOQMNyDGkyIrwrNVXV?si=VPRL-eT6QXukDkkx5GgRTQ
Index to Cantus Mariales & Cantuale Romano Seraphicum : Free Download, Borrow, and Streaming : Internet Archive
2024-11-2250 min
Authentic BiochemistryAuthentic Biochemistry Podcast. Eventuating Nature of Intrinsic Cell Surface Complexity.V. Dr. Daniel J. Guerra.18NOV24References
Biomaterials 2003. Volume 24, Issue 24, November :4385-4415
Guerra, DJ. 2024 Lecture notes
Pat Mclaughlin, John Anderson, Daniel Quine Auerbach, David R. Ferguson. 2020. "Years." Sierra Ferrell Cover.
https://youtu.be/_2W8kCk1qnU?si=4LBcoO5uE3xdEX-c
Corelli. A. 1714. Concerto in D Major Op. 6 No. 4
https://youtu.be/3smZkpqXYHs?si=-fEef0QiBAz_1yWm
2024-11-1937 min
Authentic BiochemistryAuthentic Biochemistry Podcast Cell Surface mediated Enzyme Modulation: IV. Anionic Phosphoglycerolipids & GPCR’s Dr Daniel J. Guerra 15November24References
Nature Communications 2023.volume 14. Article number: 794
Guerra, DJ.2024 Lecture notes
Mozart, WA. 1781. Serenade in B Flat " Gran Partita" K.361
https://youtu.be/BbjpuMid8DE?si=52qNaebE0gZcVK-h
2024-11-1655 min
Authentic BiochemistryCell surface Mediated Enzyme Event Ontology. II Quantitative Enzymology Primer Dr Daniel J. Guerra Authentic Biochemistry 10November24REFERENCES
Guerra, DJ. 2024. Lectures.
Sidran, B.1970."Steve Miller's Midnight Tango"
https://open.spotify.com/track/2RrpVlFjLyHb6xLjUqooOp?si=a0802956638b467b
2024-11-1148 min
Authentic BiochemistryDolichol-PP Driven ER Glycosyl PTM’s Authentic Biochemistry Podcast Dr. Daniel J. Guerra 21October24References
Clin Biochem. 2007 Jun;40(9-10):575-84
Endocr Metab Immune Disord Drug Targets. 2023;23(2):235-241.
Guerra, DJ.2024. Lectures.
Welch, R. 1971. "Future Games" Fleetwood Mac
https://open.spotify.com/track/021JldNpXGATNSC69edcBT?si=0f29d7047e9d4eb0
Vivaldi, A. 1723. "Autumn"
https://youtu.be/Z21_VpNipfg?si=ZXVDkCSFUz-JbhrE
2024-10-2254 min
Authentic BiochemistryA Dialectical Eventual Disclosure of Metabolic Temporality. Dr Daniel J. Guerra. 21Sept24. Authentic Biochemistry PodcastReferences
Plato 360 BC. "Timaeus"
Plotinus 250 AD. "Ennead III"
St Augustine 426
AD. Des Religiones.
Guerra, DJ. 2024
manuscript in preparation
Von Bingen, H.
1174. Various compositions in "Plainchant"
https://open.spotify.com/album/6E5bJgcbFNZDqTnYAOxDFw?si=gQcsyjwjQquOPAbA_Oud1A
2024-09-2243 min
Authentic BiochemistrySarcopenia IV. The CH20 Signaling Metabolome Circuit Involving the CNS, Liver, Adipose and Skeletal Muscle. Authentic Biochemistry Podcast Dr. Daniel J. Guerra 14.9.24Guerra, DJ. 2024. lecture notes
Leach, Donovan. 1967 "Mountain Jam" Allman Brothers
https://youtu.be/w9ZubobGMLs?si=uHLon1CvCiCSiqtX
2024-09-151h 02
Authentic BiochemistryNUcleotide Biochemistry Primer II. Authentic Biochemistry Podcast VIDEO. Dr. Daniel J. Guerra. 06.sept24References
Anka, P. 1967. My Way. Frank Sinatra
https://open.spotify.com/track/2YkIDPL5lGhRhomCq4S2RO?si=f3478e9330614687
Les Brown, Ben Homer, and Bud Green 1945. "Sentimental Journey". Doris Day
https://open.spotify.com/track/1SEi94JQIpkMGPAfOafNhH?si=ba4ba19ae8b547b3
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2024-09-061h 00
Authentic BiochemistryAuthentic Biochemistry Podcast Moment. Dr Daniel J Guerra. 03Sept24References
Guerra, DJ. 2024 Moment in time.
Willy and Joe Chambers. 1966. "Time Has Come Today"
https://youtu.be/hIqwzQ7g-Cc?si=H17GGSKbeEyNXuE6
2024-09-0405 min
Authentic BiochemistryImmune and neuropathophysiology of CYTOEPIGENETICS Dr. Daniel J. Guerra 18AUGUST 202References
Guerra, Daniel J. 2022. December Journal of Disease and Global Health.DOI: 10.56557/jodagh/2022/v15i38023
Lamm, R. 1969. "Beginning's" CTA.
https://youtu.be/lI-BMDnti4c?si=ZCt7yL3xRRrH2l_b
2024-08-1938 min
Authentic BiochemistryAuthentic Biochemistry Podcast Sphingolipid, ROS Mitochondrial Involvement associated with Nuclear Histone Acetylation in Alzheimer’s Disease 14.8.24 Daniel J. Guerra, PhDReferences
Guerra, DJ 2024 Lecture materials
2024-08-1551 min
Authentic BiochemistryAuthentic Biochemistry Podcast. “Scientism non fengo” Dr Daniel J. Guerra 02August24References
Guerra, DJ. 2024. unpublished
Sarasate, P.de, 1881. The Carmen Fantasy, Op. 25.
https://youtu.be/sYh0fnhKJEo?si=uRDSfFyNgI2o_fNs
Anderson,Squire, Bruford,Wakeman. 1971."Heart of the Sunrise" Yes, [Fragile,lp.]
https://youtu.be/0vNcgL9Fi4w?si=szH6TVaeyHy_vc2D
2024-08-031h 01
Authentic BiochemistryPhotosynthesis. IV. Authentic Biochemistry Podcast. Dr Daniel J. Guerra.31.7.24References
Guerra, DJ 2024. Lecture material
Anderson and Howe 1972. "Close to the Edge" Yes.
https://youtu.be/51oPKLSuyQY?si=p1MBzMqcJ8QHpAb-
2024-08-0148 min
Authentic BiochemistryAuthentic Biochemistry Midsummer Lecture Series. Plant Biochemistry Interlude. Photochemistry I. Dr Daniel J. Guerra 26.7.24References
Guerra, DJ.2024. Lecture notes
Plant Cell. 2013 Jul; 25(7): 2661–2678
Peer J. 2023; 11: e15696
Gilliland and Massey. 1955. Sid King and the 5 Strings. "Sag, Drag and Fall."
https://youtu.be/9KJzeOmHgc4?si=4GjA5H4stZDDl9nT
2024-07-271h 19
Authentic BiochemistrySaturday evening biochemical metaphysics. Authentic Biochemistry Podcast. Dr Daniel J. Guerra. 20.7.24References
Guerra, DJ. 2024. Unpublished material.
La Flame and baker. 1970. Its a Beautiful Day. "Hot Summer Day"
https://youtu.be/PUXOSe_m_dc?si=752n4PanhqKP8nFv
2024-07-2140 min
Authentic BiochemistryThe Prevailing Gignesthai of Biological Systems: “In inceptum finis est”.Dr. Daniel J. Guerra. Authentic Biochemistry Podcast. Lectures on Biochemical Epistemology.14.7.24References
Guerra, DJ. 2024. Unpublished works
Schubert, F. 1827. Piano Trio No. 2, op. 100 (D929)
https://youtu.be/yFyv7c1XyYU?si=T0VYKT-EJ5wQmQZU
Moody Blues. 1968. In Search of the Lost Chord lp.
https://youtu.be/gEj3NOW_ctw?si=Uwc1evf38wMAXdJ_
2024-07-151h 08
Authentic BiochemistryImmune Cell Biochemistry. Authentic Biochemistry Podcast Multiple Myeloma Sphingosine 1-P Associations. B cells lecture c.17 Fine (c) July7, 2024 Dr Daniel J. GuerraReferences
Guerra, DJ. 2024. Lipid lectures.
Blood Cancer J. 2024 Dec; 14(1): 24
Haydn.JM.1771. Requiem Mass in C Moll.
https://youtu.be/0ywDPn2Ykks?si=hkL4RzjRl7WbiVER
Mann, M . 1978. "Institute Chicago" Manfred Mann Earth Band. [Watch, lp]
https://youtu.be/99306Peyit0?si=dQgB8m7_TmkRpXsW
2024-07-071h 02
Authentic BiochemistryDialectical Synthesis Lecture III. The Necroptotic event in cell fate through the lens of categorical synthesis of the a priori. Dr Daniel J. Guerra. authentic Biochemistry Podcast 28.6.24References
Guerra, DJ. 2024. unpublished writings.
Seminars in Cell & Developmental Biology2020. 99:86-95
2024-06-2844 min
Authentic BiochemistryDialectical Synthesis Lecture II. 23.6.24 The Apothecary of the Alternative a priori: of Programmed cell death ontology. Dr Daniel J. Guerra Authentic Biochemistry PodcastReferences
Cell.2020 Mar 19; 180(6): 1115–1129.e13.
Guerra, D.J. 2024. Intellectual materials.
Goffin and King. 1962. "Up on the Roof" [Drfifters]
https://youtu.be/puM1k-S86nE?si=LXzWj3SqiqHnr3JB
Whitfield and Strong. 1969. "War" [Edwin Starr]
https://youtu.be/dQHUAJTZqF0?si=bfB-xARpa6aVDwQg
Kay and Godon 1963. "Thats Life" [Frank Sinatra]
https://youtu.be/TnlPtaPxXfc?si=SmFfhohympSPVKd0
Van Heusen and Cahn 1960. "Aint that a Kick in the Head" 1960 [Dean Martin]
https://youtu.be/K7jgZTDLeIs?si=bAKgzzK7mWCDJmyU
Marriot and Lane 1968. "Ma...
2024-06-2455 min
Authentic BiochemistryAuthentic Biochemistry: Dialectical Syntheses Toward an Improved Evaluation of Biochemical Research. Dr Daniel J. Guerra.20.6.24.References
Guerra, Daniel J. 2024. Essays and Notes.
Blood. 2017 Jun 15;129(24):3237-3244.
Bach, JS. 1731. Partita 6 in E Minor
https://youtu.be/TCrZyi0Sots?si=8bjua1HY5M_YWuin
Simon, P. 1968. "Old Friends"
https://youtu.be/c3NYWzHLEZw?si=vheTMVMR7f-2Ebgj
2024-06-2154 min
Authentic BiochemistryImmune Cell Biochemistry II.B lymphocyte VDJ recombination is controlled by multiple methyltransferase mechanisms. Dr Daniel J. Guerra. 01June2024.Authentic Biochemistry.References
Guerra, DJ. 2024. ImmunoBiochemistry lectures.
Commun Biol. 2022; 5: 1292.
ACS Chem. Biol. 2017, 12, 4, 958–968
Telemann, GP., 1750. Sonata in D major, TWV 44:1
https://youtu.be/xx8ooc-s7OQ?si=1vAKmdcLroNISa-P
Vivaldi, A., 1708. - Gloria (RV 589)
https://youtu.be/2eWjQOdYzMQ?si=hYSOqRuXkYUA8ATl
2024-06-0243 min
Authentic BiochemistryImmune Cell Biochemistry II. B cells The Methyltransferase regulation of RAG 2. Dr Daniel J. Guerra. 29May24. Authentic Biochemistry PodcastReferences
Guerra, DJ. ImmunoBiochemistry lectures 2024.
ACS Chem. Biol. 2017, 12, 4, 958–968
Genome Biol. 2005; 6(8): 227
Manfredini, FO. 1718. 12 Concerti Grossi | Op. 3
https://youtu.be/4t-E3wlMkDQ?si=GX0GCLUm48J4V8OY
2024-05-3046 min
Authentic BiochemistryImmune Cell Biochemistry II. B Cell Event Ontology. 28May24. Authentic Biochemistry Podcast. Dr Daniel J. GuerraReferences
ACS Chem. Biol. 2017, 12, 4, 958–968
Nat Rev Immunol. 2016 Apr; 16(4): 234–246
Guerra, DJ. 2024. Immuno-Biochemistry Lectures
Vivaldi, A. 1705. Trio Sonata in D minor, RV 63
https://youtu.be/kPpaeW3DObU?si=nfJmUWlmiK8BZXxD
Albinoni , T. 1708. Adagio in G Minor
https://youtu.be/z6WOfH2kV00?si=Mf7_6JwuLETu7YEC
Scarlotti, D. 1720. Fandango in D Minor
https://youtu.be/QQbW75y3P9g?si=MODaHGMa-MSP5Nld
2024-05-2953 min
Authentic BiochemistryImmune Cell Biochemistry II. Authentic Biochemistry Podcast. B cell Biochemistry c4. Dr Daniel J. Guerra 27.5.24.References
Guerra, DJ. 2024. Immunology Lectures (archives).
Pisendel, JG. 1720. : Concerto in E-flat major or Violin, Strings & B.c Jun P I.3
https://youtu.be/SZI2IgOOSPU?si=8xNIyvzxPnkV2zlK
Biber, HI. 1676. Passacaglia. G- minor, C.105
https://youtu.be/sgcR183f8gA?si=vYnlxQJDq8LgG_B4
2024-05-2740 min
Authentic BiochemistryImmune Cell Biochemistry. T cell Membranes Coda VII. C.22 Dr Daniel J. Guerra. Authentic Biochemistry 13.5.24
Cancers (Basel). 2023 Nov; 15(21): 5177
GUERRA, DANIEL J.(2022)CYTOEPIGENETICS: DIALECTICAL REVIEW OF A SUBCELLULAR ENDO-MEMBRANOUS COORDINATION OF GENE EXPRESSION AND CELLULAR FATE. Journal of Disease and Global Health, 15 (3). pp. 22-47. ISSN 2454-1842
McCartney-Lennon. 1968 "Martha My Dear."
https://youtu.be/RXawa90YU2s?si=_CgaG0yOdbpcflYr
2024-05-1446 min
Authentic BiochemistryImmune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.10. Immune cell membrane glycosphingolipids. Dr. Daniel J. Guerra Authentic Biochemistry 23.4.24.References
Guerra, D. 2023-24 lipid lectures
J Oleo Sci. 2011; 60(10): 537–544.
Gregorian Chants: 1100 AD. Beata es Virgo Maria
https://youtu.be/rMlWhAh2Zvc?si=B3XqzCsQYef_ee6t
Schubert, F. 1822. Schubert | Mass No. 5 in A flat major D 678
https://youtu.be/Yl5YF3PeUeI?si=AP9U_WHULnv3ItWi
2024-04-2429 min
Authentic BiochemistryBiochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry PodcastRefernces
Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies.
Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP.
https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip-
Schmelzer, JH 1664. Violin Sonatas, "Romanesca".
https://youtu.be/fB8G39y1uCA?si=hzGCK2Qq6TtIubAh
2024-04-0529 minAuthentic BiochemistryPrimer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast ProductionsDr Guerra lecture notes
2023-07-0930 minAuthentic BiochemistryPhotosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productionsGuerra: Plant biochemistry Lectures
2023-07-0629 min
Authentic BiochemistryGraduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.References
Dr. Guerra's lipid lectures
J Diabetes Investig. 2019 Nov; 10(6): 1430–1437.
2023-05-2429 min
Authentic BiochemistrySpecial Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23.Reference
Dr Guerra: Graduate Biochemistry lecture material.
2023-05-2029 min
Authentic BiochemistryImmunoEpigeneticsX. Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic BiochemistryReferences
J Cancer Res Clin Oncol. 2018; 144(6): 1065–1077
Nature Reviews Drug Discovery. Sep2014, Vol. 13 Issue 9, p673-691
Anal Cell Pathol (Amst). 2018; 2018: 787.1814
The Journal of Biological Chemistry 16/2/2018 293: 2422-2437.
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2022-12-3129 min
Authentic BiochemistryDiabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic BiochemistryReferences
Dr. Guerra lecture materials
Progress in Lipid Research Volume 74, April 2019, Pages 145-159
2022-12-3129 min
Authentic BiochemistryMembarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry PodcastReferences
Timaeus, Plato
Dr Guerra's thoughts and lectures
N Engl J Med 2005;353:604-15
2022-11-2329 minAuthentic BiochemistryMembrane Biochemistry72. DHEA and the steroidogenic pathways as biochemical prolegomena to logical judgments. Dr. Daniel J. Guerra.29.10.22b.Authentic BiochemistryReferences
Dr Guerra's lipid biochemistry lectures
Int. J. Mol. Sci. 2019, 20, 4660; doi:10.3390/ijms20194660
2022-10-3029 minAuthentic BiochemistryMembrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry PodcastReferences
Dr. Guerra's lecture notes
Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8.
2022-10-1829 min
Authentic BiochemistryMembrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic BiochemistryAl-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1
Dr Guerra Membrane lipid lectures
2022-10-1529 min
Authentic BiochemistryMembrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.References
Dr Guerra's membrane lipid lectures
Neuron 2015. Volume 85, Issue 4.Pages 695–702
2022-10-0429 minAuthentic BiochemistryMembrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic BiochemistryReferewnce
Guerra basics lecture
2022-10-0129 minAuthentic BiochemistryMembrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic BiochemistryReferences
Dr Guerra Tumor lectures
Nature Reviews Endocrinology 2020.volume 16, pages224–233
J Neurochem. 2006 Nov;99(4):1237-50. doi: 10.1111/j.1471-4159
2022-09-2327 minAuthentic BiochemistryMembrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022.References
Dr Guerra's Lecture notes
2022-09-1729 min
Authentic BiochemistryMembrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22References
Dr Guerra's lipid and membranes lectures
Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014.Volume 1841, Issue 9, Pages 1241-1246
Onco Targets Ther. 2017;10:5491-5524
2022-09-1430 min
Bitácora de GuerraTráilerHola soy Daniel Guerra, a lo largo de mi vida las preguntas del por qué me tocó a mi ser así, del por qué tengo esta discapacidad o del por qué nací con acondroplasia (enanismo vulgarmente), se han vuelto constantes en mi vida…
En Bitácora de Guerra te daré las respuestas a esta pregunta que me he hecho a lo largo de mis 45 años de vida, desde por qué me considero una persona “normal” hasta cómo he cumplido todos mis sueños (esposa, hijo, trabajo, amigos, etc)…
Cambiando la pregun...
2022-09-0401 minAuthentic BiochemistryMembrane Biochemistry XXXXII. Basic Electrobiochemistry of Biological Membranes. Dr Daniel J. Guerra. 24.8.22b Authentic Biochemistry Podcast Audio Lectures.References
Dr Guerra's membrane biochemistry/electrophyiology lectures
2022-08-2529 min
Authentic Biochemistrymembrane Biochemistry XXXXI. A priori Synthesis of Sex-linked Biochemical Dimorphism and Canonical Membrane Event Ontology. Dr. Daniel J. Guerra. 24.8.22.Authentic Biochemistry Podcast.References
Dr Guerra's lecture marginalia
2022-08-2429 minAuthentic BiochemistryMembrane Biochemistry XXXI. Corticotropin Releasing Factor and "Fear" Neurobiochemical Correlates in the CNS. Dr Daniel J. Guerra. 9Aug2022. Authentic Biochemistry PodcastReferences
Dr Guerra's neuroscience lectures
Neurosci BiobehavRev. 2019 Aug; 103: 50–59
2022-08-1030 minAuthentic BiochemistryMembrane Biochemistry XXIX. Final discussions on serum albumin and membrane disruption mediated inflammatory modulation. Dr. Daniel J. Guerra. 7bAug22.Authentic Biochemistry.References
Dr Guerra's lipid lectures
Int J Mol Sci. 2019 Oct; 20(19): 4860
JNCVolume109, Issue3May 2009 Pages 694-705
2022-08-0829 minAuthentic BiochemistryMembrane Biochemistry XXVII. Traumatic Brain Injury and Ischaemic Stroke associated neuroinflammation is mediated through membrane caveolae. Dr Daniel J. Guerra.3Aug22. Authentic Biochemistry.References
Dr. Guerra's: membrane lectures
J Clin Med. 2021 Sep; 10(17): 3795
J Neuroinflammation. 2016; 13: 264.
2022-08-0429 minAuthentic BiochemistryMembrane Biochemistry XXVI. Lipid molecular structures and membrane morphology impacting biological activity. Dr Daniel J. Guerra. 01August2022. Authentic Biochemistry Podcast Productions.References
Dr Guerra's lipid lecture archive
2022-08-0229 minAuthentic BiochemistryMembrane Biochemistry XIV. Apoptosis and Necroptosis review. Dr. Daniel J. Guerra. 8 July 2022. Authentic Biochemistry PodcastReferences
Dr Guerra's notes
Oncogene. 2009 Sep 3;28(35):3097-110
Mol Cell Biol. 2005 Aug;25(15):6363-79
J Neuroinflammation. 2019; 16: 236.
2022-07-0926 minAuthentic BiochemistryMembrane Biochemistry X. Dialectical Event Ontologies and the Complexity of Biological Systems. Dr. Daniel; J.Guerra 2 July 2022 Authentic BiochemistryReferences
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2022-07-0229 minAuthentic BiochemistryMembrane Biochemistry VIII. The basics of lipid membranes. Part 1. Dr Daniel J. Guerra. Authentic Biochemistry Podacst Production. 28.6.22References
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PNAS September 28, 2010 107 (39) 16783-16787;
2022-06-2929 min
Authentic BiochemistryMembrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic BiochemistryReferences
Dr Guerra's notes
Sci Signal. 2016 Aug 23; 9(442): ra83
Front. Pharmacol., 24 April 2019
2022-06-2129 minAuthentic BiochemistryCytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022References
Dr Guerra's notes
Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:436
JAMA. 2008;299(11):1345-1350
2022-06-0629 min
Authentic BiochemistryCytoEpigenetics I. Introduction. Dr. Daniel J. Guerra . 22.4.22. Authentic Biochemistry Podcast ProductionsReferences
Introductory remarks from Guerra's research
Trends in Cell Biology, 2017-06-01, Volume 27, Issue 6, Pages 453-463.
2022-04-2329 minAuthentic BiochemistryDiabetes XXXV. Rodent model adipose mitochondrial respiratory contribution to obesity control involves a selenium protein and UCP1 sulfenylation. Dr Daniel J. Guerra. Authentic Biochemistry.18.4.22References
Dr. Guerra Lipid and Intermediary Metabolism lectures
Cell Reports 2022. 38, 110566
PNAS July 24, 2017 | 114 (32) 8649-8654
2022-04-1929 min
Authentic BiochemistryDiabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22References
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2022-04-1729 minAuthentic BiochemistryDiabetes XXX. The pleitropic roles of free fatty acids and PPAR's as mediating insulin sensitivity, intermediary metabolism and the inflammatory response in T2D.Dr Daniel J. Guerra 13.4.22. AuthenticReferences
Dr. Guerra lecture notes
Prog Neurobiol. 2018 Apr-May; 163-164: 27–58.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:28–40
2022-04-1329 min
Authentic BiochemistryDiabetes XXVII. Dyslipidaemia and the Insulin Resistance Axis. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast 7April2022.References
Dr. Guerra's lectures
Curr Med Chem. 2017;24(17):1827-1852
Cancer Res. 2018 Apr 1; 78(7): 1713–1725
2022-04-0829 minAuthentic BiochemistryDiabetes XXIV. Sphingosine 1-phosphate targeting and the abalation of primary breast cancer metastasis: IL6 mediated tumorigenesis blockade? Dr Daniel J. Guerra 01April2022. Authentic BbiochemistryReferences
Dr Guerra's notes
Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042
2022-04-0229 minAuthentic BiochemistryDiabetes XXIII. Obesity-associated IL6 and sphingosine 1-phosphate are linked to breast cancer.Dr. Daniel J. Guerra. 31 March 2022. Authentic BiochemstryReferences
Dr. Guerra's lecture notes
Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042
Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.
2022-04-0129 min
Authentic BiochemistryDiabetes XXII. Obesity and cancer are linked by inflammation and dyslipidaemia. Dr Daniel J. Guerra. 30.3.22 Authentic BiochemistryReferences
Dr Guerra's lectures notes
Cancer Res. 2018 Apr 1; 78(7): 1713–1725
Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.
2022-03-3129 minAuthentic BiochemistryDiabetes XIV. The Neuropsychiatric/Neurodegeneration axis from Sphingomyelin Degeneration to Increased Inflammation. Dr. Daniel J. Guerra. 17.3.22. Authentic Biochemistry ProductionsReferences
Dr Guerra Lecture archives
Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021.Volume7, Issue1 e12217
EBioMedicine. 2015 Dec; 2(12): 1888–1904
2022-03-1729 min
Authentic BiochemistryDiabetes IX. The role of peroxisomes in ether-linked lipid biosynthesis. Dr.Daniel J. Guerra. 07March2022. Authentic Biochemistry Podcast productionReferences
Dr Guerra's lecture material
2022-03-0829 minAuthentic BiochemistryDiabetesVIII. Subcellular organization and the role of lipid metabolism in mitochondria and peroxisomes. Dr Daniel J. Guerra. 05March22. Authentic BiochemistryFrom Dr. Guerra's lecture archives
2022-03-0530 min
Authentic BiochemistryDiabetes IV. Pancreatic Exocrine Insufficiency in Types I, II, and III Diabetes Mellitus. Dr DAniel J. Guerra. 28.2.22. Authentic BiochemistryReferences
Dr. Guerra Lecture notes
Int J Endocrinol. 2015; 595649
2022-03-0129 min
Authentic BiochemistryType 2 Diabetes I. Initial lecture describing insulin resistance and dyslipidaemia. Dr Daniel J. Guerra 22.2.22 Authentic Biochemistry Podcast.References
Dr. Guerra lecture notes
Reviews in Endocrine and Metabolic Disorders. 2020. 21: 631–643.
J Lipid Res. 2015 Mar; 56(3): 588–598.
2022-02-2329 min
Authentic BiochemistryFatty Acids IX. The Monounsaturated fatty acid inhibition of ferroptosis and apoptosis leads to cancer progression. Pharmacotherapeutic Considerations. Dr Daniel J. Guerra. 17.2.22 Authentic Biochem.References
Dr. Guerra's notes-unpublished
Cancer Res. 2019 Oct 15; 79(20): 5355–5366.
2022-02-1830 minAuthentic BiochemistryFatty Acids II. Obesity and lipotoxicity. Dr Daniel J. Guerra. Authentic Biochemistry 04. February 2022References
Dr. Guerra's lecture notes
Int J Mol Sci. 2021 Jan; 22(1): 330
2022-02-0529 minAuthentic BiochemistryFatty Acids I. Dr. Daniel J. Guerra. 03.02.22. Authentic Biochemistry PodcastReferences
Dr. Guerra's lecture notes
Int J Mol Sci. 2021 Jan; 22(1): 330.
2022-02-0429 minAuthentic BiochemistryAnabolism V. The nucleic acids. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast.28.01.22References
Dr. Guerra's lecture notes
2022-01-2929 minAuthentic BiochemistryAnabolism IV. Cholesterologenesis. Dr Daniel J. Guerra. 26 January 2022. Authentic Biochemistry PodcastFrom Dr. Guerra's lecture notes
2022-01-2730 minAuthentic BiochemistryAnabolism III. Fatty acid synthesis de novo . Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Productions. 25.01.22References
Dr. Guerra lecture notes
2022-01-2629 minAuthentic BiochemistryMembrane Biochemistry Primer and Introduction to Aging. Dr. Daniel J. Guerra. Authentic Biochemistry Productions. 13.9.21Dr. Guerra introduces a primer on membrane biochemistry in preparation for a florid analysis of autophagy and the various forms of programmed cell death linked to the aging human.
References
Cell Discovery volume 7, Article number: 4 (2021)
2021-09-1329 minAuthentic BiochemistryPharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.A.D.M.E.
Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492.
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2021-06-1029 min
Pensemos lo InternacionalIX EL Gran Suicidio de la Razón: La Gran Guerra - inicios¿Cómo es posible que la civilización hubiera llegado a aquello? ¿Porque habían muerto tantos millones inútilmente? Los caprichos, los miedos, las frustraciones y las ansias de revanchismo llevaron a esa sociedad tan civilizada a dejarse llevar por sus instintos.
Apocalipsis: La Primera Guerra Mundial - 2. Temor en https://www.youtube.com/watch?v=ZccIaqLY1K0
La Guerra de Trincheras, la Guerra Química, la Guerra aérea, la llegada del bombardero en 50 Cosas que hay que saber sobre la Guerra de Robin Croos
La Primera Guerra Mundial en Guerras...
2021-05-0123 min
Pensemos lo InternacionalEl Gran suicidio de la razón: La Gran Guerra - Origenes¿Cómo el mundo llegaría a desatar la Primera Guerra Mundial? En este episodio, el primero de nuestro especial ahondaremos los contextos políticos y sociales que le darían forma a este gran Suicidio de la razón. La Primera Guerra Mundial puso fin a un largo período de Paz sostenida en Europa: una época en la que se hablaba confiadamente de prosperidad, de progreso y de esperanza. Y sin embargo en 1914 el continente se lanzó de cabeza a un conflicto catastrófico, que mató a millones de personas, desangró las economías nacionales, derrumbo los imperios...
2021-04-2424 min
Authentic BiochemistryCondensed Bioenergetics : Dr Guerra Drives the Electron Transport Chain via Standard Oxidation Reduction Potentials. 21.3.21Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra
Authentic Biochemistry Studios
21.3.21
2021-03-2229 minAuthentic BiochemistryCell Cycle kinase inhibition may improve healthy cardiac aging while promoting global tumorigenesis. Authentic Biochemistry 10Feb2021 by Dr Guerra.*Oncogenesis eventuates genetic mutation to epigenetic gene expression mechanisms with molecular signatures either inappropriately proscribed, incorrectly prescribed upon writing as dangerous and deleterious, or erasure; leaving a corrupted chromatin result.
*Tumor cells obtain proliferative autonomy, autophagous –self-maintenance in growth and signaling, neovascularization for nutrient and oxygen supply, and resistance to anti-proliferative and apoptotic stimuli
*In resting cells, the cell cycle is strictly managed by a set of regulatory proteins that control the various cell cycle checkpoints and this will become dysfunction during the early transforming stage of the tumorigenesis via the unregulated dismantling of tumor suppres...
2021-02-1129 min
Authentic BiochemistryThe Corticotropin Releasing Factor and the Somatosensory Catecholamine Circuit in ExtraDimensional (attentional) Shifting. Dr Guerra 20 Jan 2021.AB.Adaptation to stress-such as the fear response obtains dopaminergic input to striatum and prefrontal cortex and is thought to signal unexpected events and facilitate a shift in attention to promote new learning within the contralateral primary somatosensory cortex (SI) which has been associated with the agentic categories of both the quality and quantity of thought event ontology. This process works in conjunction with the bilateral secondary somatosensory cortex (SII) process involved in executive decision making. Where stimulated, the primary sensory motor-neuronal process is integrated with novel extra-dimensional learning .
Recall that this fear stress response can lose functional valenc...
2021-01-2028 min
Authentic BiochemistryAn Immunological Distinction between Senescence linked Secretory Phenotypes: SASP vs. Midas. Dr. Dan Guerra. Authentic Biochemistry 16 Jan 2021Non-uniform ageing is a major associative risk factor for cancer and degenerative diseases and mitochondrial dysfunction is linked to cellular senescence in association with cell cycle arrest, telomerase decline and nucleic acid/lipid/protein oxidation. Indeed, mitochondrial dysfunction comprises a distinct type of cellular senescence; mitochondrial SIRT3 or SIRT5, can induce Mitochondrial Dysfunction Associated-Senescence (MiDAS)
Senescence is a chronological and pathophysiological sequenced event response that restricts mitotic division and thus aberrant proliferation of damaged, infected and/or tumor inducing cells. Because these cells are senescent and exhibit low anabolic currency to present self-produced antigen epitopes as displayed...
2021-01-1729 minAuthentic BiochemistryT cell metabolic Dialectics : deriving bioenergetic supremecy from glycolysis through fatty acid and lipid synthesis to ultimate fatty acid oxidation and ATP generation. Dr Daniel J. GuerraAuthentic Biochemistry Podcast 29 December 2020
Daniel J. Guerra Ph.D.
•All scientific inquiry should start with dialectical method that uses the current knowledge base to generate various specific Theses and then follow each with the counter-argument by employing the Square of Opposition thus producing Anti-theses and then, making the third movement, which allows for a Synthesis that has the flavor of rejection, acceptance or indifference.
*Downstream of co-stimulation and PI3K-AKT, the mammalian target of Rapamycin (mTOR) kinase pathway integrates multiple signals and regulates anabolic metabolic reprogramming in T cells exiting qu...
2020-12-3029 minAuthentic BiochemistryFrom Glucose to Triacylglycerol in the developing T lymphocyte. Dr Daniel J. Guerra. Authentic Biochemistry 21 December 2020In this episode Dr Guerra provides a concise description of T lymphocytic fatty acid synthesis from glucose via cytosolic glycolysis, mitochondrialpyruvate dehydrogenase, pyruvate carboxylase, and citrate synthase and a return to the cytosol for ATP citrate lyase and the homodimeric polyprotein complex FAS to generate palmitoyl-ACP.
This ability of antigen-MHC Antigen Presenting Cell TCR - activated T lymphocytes to prepare for massive cytokine and chemokine expression requires a biochemical poise to use newly synthesized intracellular triacylglycerol to drive cellular exapnsion and effector-mediated immune responses.
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2020-12-2329 min
Authentic BiochemistryThe Misguided Linkage of Potentially Ablating Aging -Associated Metabolic Syndrome by tracking NAD+ serum levels. Dr. Daniel Guerra. 17 December 2020.Metabolic syndrome (MetSyn)is a dyslipidaemic chronic and aging linked sedentary life-style constellation of disease presentations including metabolic disorganization, prodromal Type 2 diabetes and a prominent connection to hypertension-most prominently associated with over-eating and obesity. MetSyn is often prolegomena to middle-age onset CVD, cancer and neurodegeneration. High caloric density soluble carbohydrate nutrition, lack of fasting and the species-specific metabolic inability to convert fatty acids into glucose via gluconeogenesis, provide a pathobiochemical poise toward MetSyn.
As Nicotinamide Adenine Dinucleotide (NAD+) levels decline with age and obesity a potential suppression of NAD (H)-dependent enzymes in oxidative phosphorylation, the TCA cyc...
2020-12-1729 min