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SLAS Technology Authors Talk TechAuthor Interview: Utilizing 3D Technologies to Study Tumor Cell DisseminationIn this episode, podcast host David Pechter invites SLAS Technology featured author Dr. Hossam Ibrahim (University College Dublin) to discuss his research on the dissemination of tumor cells to understand the mechanisms behind cancer metastasis. Tune in to hear how the research team developed a migration assay combining 3D models and a physiologically relevant extracellular matrix. Hear about the unique challenges faced by researchers while orchestrating the application of 3D technologies with high throughput screening methods.For more, read Dr. Ibrahim's paper "A Biomimetic High Throughput Model of Cancer Cell Spheroid Dissemination onto Aligned Fibrillar Collagen". For...2022-12-1413 minSLAS Technology Authors Talk TechBehind the Special Issue: Single Cell Analysis TechnologiesBehind the Special Issue: Join podcast host David Pechter as he invites Joseph de Rutte (Partillion Bioscience) to discuss the paper: “Sorting single-cell microcarriers using commercial flow cytometers”. This research was featured in the recent SLAS Technology special issue, Single Cell Analysis Technologies. Listen in as they discuss the unique formation of microscopic, bowl-shaped containers they call nanovials, and the applications of these cell carriers in flow cytometry for functional single-cell assays. Dr. Joe de Rutte received his B.S. and M.S. in Mechanical Engineering from the University of California, Santa Barbara in 2014 and 2016 and received a Ph...2022-06-1516 minSLAS Technology Authors Talk TechAssay Guidance Manual: Technologies that MatterJoin SLAS Podcast Host Dave Pechter as he welcomes R. Graham Cooks, Ph.D. (Purdue University) and Nicolás M. Morato (Purdue University) to discuss their research, featured in the latest Issue of SLAS Technology. They are joined by Nathan P. Coussens, Ph.D. (Frederick National Laboratory for Cancer Research), guest editor of this special issue. Together, they discuss the article “Automated High-Throughput System Combining Small-Scale Synthesis with Bioassays and Reaction Screening”. This work explores the application of desorption electrospray ionization (DESI) for high-throughput synthetic chemistry, chemical reacti...2021-12-0820 minSLAS Technology Authors Talk TechIn Conversation: SLAS Editors on Open AccessJoin Jill Hronek, SLAS Director of Marketing and Communications, and Ally Jump, SLAS Publishing Manager, as they speak with SLAS Discovery and SLAS Technology’s respective Editors-in-Chief, Robert M. Campbell, Ph.D., (Twentyeight-Seven Therapeutics, Boston, MA USA) and Edward Kai-Hua Chow, Ph.D., (National University of Singapore, Singapore) about SLAS’s new Open Access model for the Society’s two peer-reviewed journals. Beginning January 1, 2022 both SLAS Discovery and SLAS Technology will be available Open Access and through a new publisher, Elsevier. Tune in to have your questions answered about all things publishing and open access and hear what oth...2021-10-2713 minSLAS Technology Authors Talk TechLow-Cost 3D Bioprinters: State of The Market and Observed Future TrendsRecent innovations and accelerating market availability have led to tremendous growth in demand for affordable 3D bioprinter hardware. Podcast host David Pechter invites SLAS Technology August cover authors Roman Voronov and Anh Tong of the New Jersey Institute of Technology to discuss their review of the market, and their predictions about where it is going.This month's SLAS Technology cover article provides essential insights to researchers entering a market flooded with different types of low-cost bioprinter models. Click here to read the full review!2021-08-2515 minSLAS Technology Authors Talk TechDiscussion on SLAS Featured Talk: Harnessing Synthetic Biology and Deep Learning to Fight PathogensPodcast Editor David Pechter hosts Jim Collins of the MIT Department of Biological Engineering to discuss his talk on the harnessing of deep learning to fight pathogens. The future of medicines using synthetic biology is a rapidly expanding field, with applications including engineered diagnostics, gene and cell therapies, and the deployment of mRNA vaccines to fight the COVID-19 pandemic. The application of deep learning is accelerating this research, facilitating rapid candidate identification for novel therapies.2021-07-2816 minSLAS Technology Authors Talk TechSpecial Collection: AI in Process AutomationVolume 26 Issue 1, February 2021Dave Pechter discusses the February SLAS Technology Special Collection AI in Process Automation with Guest Editor Cenk Undey (Amgen), which includes the following papers:Artificial Intelligence Effecting a Paradigm Shift in Drug Development by Masturah Bte Mohd Abdul RashidArtificial Intelligence (AI) to the Rescue: Deploying Machine Learning to Bridge the Biorelevance Gap in Antioxidant Assays by Sunday Olakunle Idowu and Amos Akintayo FatokunDeep Learning and Computer Vision Strategies for Automated Gene Editing with a Single-Cell Electroporation Platform by Cesar Patino, Prithvijit Mukherjee, Vincent Lemaitre, et al.2021-01-1312 min
Sage Life & Biomedical SciencesSLAS Technology Author Talk Tech: Special Collection: AI in Process AutomationVolume 26 Issue 1, February 2021 Dave Pechter discusses the February SLAS Technology Special Collection AI in Process Automation with Guest Editor Cenk Undey (Amgen), which includes the following papers: Artificial Intelligence Effecting a Paradigm Shift in Drug Development by Masturah Bte Mohd Abdul Rashid Artificial Intelligence (AI) to the Rescue: Deploying Machine Learning to Bridge the Biorelevance Gap in Antioxidant Assaysby Sunday Olakunle Idowu and Amos Akintayo Fatokun Deep Learning and Computer Vision Strategies for Automated Gene Editing with a Single-Cell Electroporation Platform by Cesar Patino, Prithvijit Mukherjee, Vincent Lemaitre, et al. 2021-01-1212 minSLAS Technology Authors Talk TechSpecial Collection: Advances in Technology to Address COVID-19Volume 25 Issue 6, December 2020Dave Pechter discusses the December SLAS Technology Special Collection Advances in Technology to Address COVID-19 with Associate Editor Pak Kin Wong (The Pennsylvania State University), which includes Professor Wong's review Advances in Viral Diagnostic Technologies for Combating COVID-19 and Future Pandemics.2020-11-1809 min
Sage Life & Biomedical SciencesSLAS Technology Author Talk Tech: Special Collection: Advances in Technology to Address COVID-19Volume 25 Issue 6, December 2020 Dave Pechter discusses the December SLAS Technology Special Collection Advances in Technology to Address COVID-19 with Associate Editor Pak Kin Wong (The Pennsylvania State University), which includes Professor Wong's review Advances in Viral Diagnostic Technologies for Combating COVID-19 and Future Pandemics.2020-10-0809 min
Sage Life & Biomedical SciencesSLAS Technology Authors Talk Tech: Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology ProgrammableVolume 25 Issue 5, June 2020 Dave Pechter discusses with Varun Bhaskar Kothamachu, Ph.D. (Head of Product, Digi.Bio) & Sabrina Zaini (Head of Operations, Digi.Bio) their featured research article, "Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable."2020-10-0813 min
Sage Life & Biomedical SciencesSLAS Technology Authors Talk Tech: Special Issue: Carbohydrate Structure Analysis: Methods and ApplicationsSLAS Technology 25.4 August 2020 Dave Pechter discusses with Christian Heiss & Parastoo Azadi regarding the SLAS Technology Special Issue: Carbohydrate Structure Analysis: Methods and Applications.2020-10-0813 minSLAS Technology Authors Talk TechRole of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology ProgrammableVolume 25 Issue 5, October 2020Dave Pechter discusses with Varun Bhaskar Kothamachu, Ph.D. (Head of Product, Digi.Bio) & Sabrina Zaini (Head of Operations, Digi.Bio) their featured research article, "Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable."2020-09-1413 minSLAS Technology Authors Talk TechSpecial Issue: Carbohydrate Structure Analysis: Methods and ApplicationsSLAS Technology 25.4 August 20202020-07-2013 minSLAS Technology Authors Talk TechTraceable Impedance-Based Dispensing and Cloning of Living Single Cells and Impedance-Based Single-Cell PipettingVolume 25 Issue 3, June 2020Dave Pechter discusses with Georges Muller & Yann Barrandon their two featured research articles, "Traceable Impedance-Based Dispensing and Cloning of Living Single Cells" and "Impedance-Based Single-Cell Pipetting."Traceable Impedance-Based Dispensing and Cloning of Living Single Cells: Single-cell cloning is essential in stem cell biology, cancer research, and biotechnology. Regulatory agencies now require an indisputable proof of clonality that current technologies do not readily provide. Here, we report a one-step cloning method using an engineered pipet combined with an impedance-based sensing tip. This technology permits the efficient and traceable isolation of living cells, stem...2020-06-0113 minSLAS Technology Authors Talk TechCURATE.AI: Optimizing Personalized Medicine with Artificial IntelligenceVolume 25 Issue 2, April 2020Dave Pechter discusses with Agata Blasiak & Theodore Kee regarding their article, "CURATE.AI: Optimizing Personalized Medicine with Artificial Intelligence." The clinical team attending to a patient upon a diagnosis is faced with two main questions: what treatment, and at what dose? Clinical trials’ results provide the basis for guidance and support for official protocols that clinicians use to base their decisions upon. However, individuals rarely demonstrate the reported response from relevant clinical trials, often the average from a group representing a population or subpopulation. The decision complexity increases with combination treatments where dru...2020-04-0119 minSLAS Technology Authors Talk TechSpecial Issue: Flexible Analytical Devices for Point-of-Care TestingVolume 25 Issue 1, February 2020Dave Pechter discusses with Hideaki Tsutsui & Peter Lillehoj regarding February's Special Issue. Over the last decade, flexible analytical devices have received considerable attention in both academia and industry. Compared to conventional analytical devices which are generally made from rigid materials, such as silicon, glass, and plastics, flexible devices offer several unique advantages, such as simplified fabrication, lower costs, enhanced portability and disposability, and compliance to curved or deforming surfaces. For these reasons, flexible analytical devices are well suited for many diagnostic applications, including wearable and in vivo sensing, and point-of-care testing for disease detection...2020-02-0111 minSLAS Technology Authors Talk TechAutomated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid RepellencyVolume 24 Issue 6, December 2019Dave Pechter discusses with Chao Li the article, "Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency." Lossless processing and culture of rare cells (e.g., circulating tumor cells, drug-persistent microorganisms) at single-cell level is of great significance in understanding the heterogeneity of carcinogenesis or human pathogenesis caused by microbial infection. Current single-cell isolation techniques like fluorescence-activated cell sorting (FACS) require relatively large sample volume and cell number to work with, and inflict sample loss and reduced cell viability from the processing. While microfluidic and single-cell printing techniques allow the h...2019-12-0110 min
Sage Life & Biomedical SciencesSLAS Technology Authors Talk Tech: Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid RepellencyDave Pechter discusses with Chao Li the article, "Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency."2019-11-2010 minSLAS Technology Authors Talk TechSpecial Issue: Engineering Innovations for Fundamental Biology and Translational MedicineSLAS Technology 24.5 October 2019Professors at Johns Hopkins University, Claire Hur and Deok-Ho Kim, discuss their special issue, "Engineering Innovations for Fundamental Biology and Translational Medicine."In this special issue of SLAS Technology, the editors showcase reviews and original research reports addressing the accuracy in diagnostic and prognostic tests performed on the patient-derived specimen, an emerging technology demand for personalized medicine.Soojung Claire Hur, Ph.D., is Clare Boothe Luce Assistant Professor in the Department of Mechanical Engineering at Johns Hopkins Whiting School of Engineering, and an expert in microfluidics. Deok-Ho Kim, Ph.D...2019-10-0110 minSLAS Technology Authors Talk TechTechnologies for the Directed Evolution of Cell TherapiesVolume 24 Issue 4, August 2019UCLA Professor, Dino Di Carlo, discusses his review paper, "Technologies for the Directed Evolution of Cell Therapies." The next generation of therapies is moving beyond the use of small molecules and proteins to using whole cells. Compared with the interactions of small-molecule drugs with biomolecules, which can largely be understood through chemistry, cell therapies act in a chemical and physical world and can actively adapt to that world, amplifying complexity but also the potential for truly breakthrough impact. Although there has been success in introducing targeting proteins into cells to achieve a t...2019-08-0111 minSLAS Technology Authors Talk TechSpecial Collection: Advances in 3D and Organoid Cell CultureSLAS Technology 24.1 February 2019Guest Editor Richard M. Eglen of Corning Life Sciences (Tewksbury, MA, USA) talks about a new collection of reviews and original research reports that illustrate how the combination of human iPS cells and 3D cell culture technology provide powerful new approaches to the development of novel and more effective therapies. Free access to the published collection is sponsored by Corning Life Sciences.2019-02-0113 minSLAS Technology Authors Talk TechImproved Fluorescence Methods for High-Throughput Protein Formulation ScreeningSLAS Technology 23.6 December 2018University of Kansas researchers Yangjie Wei and Nicholas Larson talk about how they used a steady-state/lifetime fluorescence-based, high-throughput platform to develop a general workflow for direct formulation optimization under analytically challenging but commercially relevant conditions.2018-12-0106 minSLAS Technology Authors Talk TechSpecial Issue: The Internet of Things (IoT) in the Life Sciences LaboratorySLAS Technology 23.5 October 2018Guest Editor James M. Gill, II, Ph.D., of BFL Consulting (Madison, CT) talks about how the October 2018 issue of SLAS Technology showcases life sciences researchers who are pioneering the use of powerful yet accessible and low-cost IoT technologies in their laboratories. Ten articles illustrate how IoT is being used to optimize factors such as throughput, cost, uptime and result quality.2018-10-0107 minSLAS Technology Authors Talk TechContinuous and Quantitative Purification of T-Cell Subsets for Cell Therapy Manufacturing Using Magnetic Ratcheting CytometrySLAS Technology 23.4 August 2018UCLA’s Coleman Murray, Ph.D., talks about his contribution to the August 2018 special issue of SLAS Technology on Enabling Technology in Cell-Based Therapies by guest editor Chris Puleo and his associates at General Electric Global Research. Murray’s article illustrates an important example of how new technologies are changing automation and processing in cell therapy manufacturing.2018-08-0107 minSLAS Technology Authors Talk TechSpecial Issue: Quantitative Imaging in Life Sciences and Biomedical ResearchVolume 23 Issue 3, June 2018Guest Editor Anand D. Jeyasekharan, Ph.D., of the Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, talks about the SLAS Technology special issue on Quantitative Imaging in Life Sciences and Biomedical Research. His insight and the articles in this special issue offer a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.2018-06-0107 minSLAS Technology Authors Talk TechFully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish EmbryosVolume 23 Issue 2, April 2018Christian Pylatiuk, Prof. Dr. med., of the Karlsruhe Institute of Technology, Institute for Automation and Applied Informatics in Eggenstein-Leopoldshafen, Germany, discusses his new article, which describes a zebrafish embryo sortying system with two cameras and image processing based on template-matching algorithms.2018-04-0109 minSLAS Technology Authors Talk TechFast and Label-Free Isolation of Circulating Tumor Cells from Blood: From a Research Microfluidic Platform to an Automated Fluidic Instrument, VTX-1 Liquid Biopsy SystemVolume 23 Issue 1, February 2018Meet Elodie Sollier-Christen of Vortex Bioscienes as she talks with SLAS Technology Podcast Editor David Pechter about the groundbreaking technology that earned her the 2017 SLAS Innovation Award.2018-02-0115 minSLAS Technology Authors Talk TechEmerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility TestingSLAS Technology 22.6 December 2017Listen to author Weian Zhao of the University of California, Irvine, as he talks about his new article, which summarizes and analyzes representative emerging micro- and nanotechnologies and automated systems for bacterial ID/AST, including phenotypic and molecular methods; discusses representative point-of-care systems that integrate sample processing, fluid handling, and detection for rapid bacterial ID/AST; and highlights major challenges and potential future endeavors toward improving clinical outcomes.2017-12-0110 minSLAS Technology Authors Talk TechHeart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and AlignmentSLAS Technology 22.5 October 2017Dr. Elzbieta Jastrzebska of Warsaw University of Technology (Poland) talks about how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.2017-10-0107 minSLAS Technology Authors Talk TechDigital AssaysSLAS Technology 22.4 August 2017Dr. Amar Basu of Wayne University talks with SLAS Technology Podcasts Editor David Pechter about his in-depth, two-part review on digital assays (partitioning statistics and digital PCR; digital protein and cell assays).2017-08-0116 minSLAS Technology Authors Talk TechMaking N-of-1 Medicine a RealitySLAS Technology 22.3 June 2017Special issue guest editors Dean Ho, Ph.D. and Ali Zarrinpar, M.D., Ph.D. of the University of California, Los Angeles, talk about the state of personalized and precision medicine and the 11 reviews and reports that explore innovation from a cross section of the disciplines driving major advances in PPM.2017-06-0112 minSLAS Technology Authors Talk TechNew Technologies for Rapid Bacterial Identification and Antibiotic Resistance ProfilingSLAS Technology 22.2 April 20172016 SLAS Innovation Award Winner Shana O. Kelly talks about new solutions for faster bacterial identification and analysis, and recent advances in managing infectious diseases by leveraging single-cell analysis, microfluidic concentration and detection strategies, and ultrasensitive readout mechanisms.2017-04-0109 minSLAS Technology Authors Talk TechThe 2017 SLAS Technology TenSLAS Technology 22.1 February 2017From being able to move liquid with sound to dispense primary cells and DNA to microfluidic-based immunoassays, SLAS Technology Editor-in-Chief talks about the groundbreaking achievements reflected in the 2017 SLAS Technology Ten. This year’s highlighted papers push the envelope of what is possible with automation, integrating new functions into high-throughput sample preparation and screening to further drive efficiencies in research.2017-02-0112 min