Shows
The Metabolic LinkHormone Health for Performance and Longevity | Kyle Gillett, MD | The Metabolic Link Ep.67Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs here!If you’re a clinician, scientist, or anyone interested in taking a deep dive into the complexities of hormone regulation, this episode of The Metabolic Link Podcast is for you! Recorded live at Metabolic Health Summit 2024, this in-depth presentation by Dr. Kyle Gillett—dual board-certified in family and obesity medicine—dives deep into the biochemical, clinical, and therapeutic layers of hormone health.From his foundational “Seven Pillars of Health” to cutting-edge insights on peptides...2025-05-0654 minThe Metabolic LinkJournal Club: The Rise of Fatty Liver Disease and its Metabolic Roots | Ep.66Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.comIn today's journal club episode, co-hosts of The Metabolic Link, Dr. Angela Poff and Dr. Dominic D'Agostino, unpack the startling rise of non-alcoholic fatty liver disease (NAFLD)—a silent epidemic affecting millions worldwide. Tune in as they break down groundbreaking new research revealing how NAFLD isn't just impacting adults, but alarmingly, children and adolescents too.You'll learn about the latest updates in terminology, such as Metabolic Dysfunction Associated St...2025-04-2358 minThe Metabolic LinkThe Metabolic Impact of GLP-1s on Obesity | Spencer Nadolsky, DO | Ep.65Join us for a FREE Live Q&A with Dr. Spencer Nadolsky on April 22nd at 9am PT / 12pm ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of expert-led videos on metabolic health and therapy, CME opportunities, and more here!In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Spencer Nadolsky—board-certified obesity and lipid specialist, former NCAA heavyweight wrestler, and founder of Vineyard—to explore one of the most hotly debated and often mi...2025-04-1159 minThe Metabolic LinkReversing Heart Disease Through Metabolic Health | Philip Ovadia, MD | Ep.64Join us for a Live Q&A with Dr. Ovadia on March 31st at 12 PM PT / 3 PM ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of videos on metabolic health (including Dr. Ovadia’s presentation, Fanning the Flames: Inflammation, Insulin Resistance, and Heart Disease), CME opportunities, and more. Register here!Dr. Philip Ovadia is a cardiac surgeon on a mission to change how we think about heart disease. After performing thousands of surgeries, he realized that most of his patients didn’t need...2025-03-251h 06The Metabolic LinkThe Mitochondrial Link to Mental Illness | Ana Andreazza, PhD | The Metabolic Link Ep.63Mitochondria do more than power our cells—they may hold the key to understanding and treating mental illness.In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Ana Andreazza, a leading expert in mitochondrial health at the University of Toronto.Dr. Andreazza has pioneered research linking mitochondrial dysfunction to psychiatric disorders like bipolar disorder, utilizing groundbreaking 3D brain organoid models to study neurotransmission. She also leads research on mitochondrial transplantation, a potential game-changer in regenerative medicine.Join us as we explore how mitochondria influence mood, metabolism, and over...2025-03-111h 04The Metabolic LinkOptimizing Metabolic Health | MHS Panel Discussion | The Metabolic Link Ep. 62Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs here.What’s the best way to optimize metabolic health? In this powerhouse episode of The Metabolic Link, we bring together leading experts including Dr. Ben Bikman, Dr. Richard Johnson, Dr. Jonathan Jun, Dr. Nick Norwitz, and Dave Feldman from our Optimizing Metabolic Health Symposium filmed at Metabolic Health Summit 2024 and hosted by Dr. Dominic D'Agostino.In this discussion, you'll dive into some of the biggest questions in metabolism, including:What are the lo...2025-02-2737 minThe Metabolic LinkTargeting Cancer Metabolism: The Future of Oncology | Dr. Tomás Duraj | The Metabolic Link Ep. 61What if we could target cancer at its metabolic core? In this episode of The Metabolic Link, Dr. Dominic D’Agostino is joined by Dr. Tomás Duraj, a physician and cancer metabolism researcher working alongside Dr. Thomas Seyfried.Dr. Duraj is the lead author of a groundbreaking review on ketogenic metabolic therapy for glioblastoma, bringing together leading experts to explore how metabolic strategies could reshape cancer treatment.In this deep-dive conversation, they discuss the bioenergetics of cancer, the role of mitochondria, the Warburg effect, and why targeting glucose and glutamine metabolism may be the key...2025-02-111h 32The Metabolic LinkA Ketogenic Approach to Type 1 Diabetes | Dr. Ian Lake | The Metabolic Link Ep.60Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.com Can a ketogenic diet revolutionize the management of type 1 diabetes? In this episode of The Metabolic Link, Dr. Ian Lake, a UK-based physician and type 1 diabetes advocate, shares his personal and professional journey in using low-carb and ketogenic diets to improve metabolic control.Diagnosed with type 1 diabetes at 36, Dr. Lake initially followed conventional high-carb recommendations—until he discovered the power of nutritional ketosis. He breaks down how reducing insulin volumes, op...2025-01-291h 07The Metabolic LinkChad Vanags | Patient Perspective: Why I Don’t Trust You & How We Can Fix It | The Metabolic Link Ep.59Become a member of The Metabolic Initiative to access exclusive ad-free episodes, watch 100s of videos on metabolic health, and earn CMEs here.In this powerful and unfiltered episode of The Metabolic Link, we're sharing a full presentation by Chad Vanags, a former SaaS executive and entrepreneur who has turned his stage 4 lung cancer diagnosis into a mission to reshape the way we think about healing. Recorded live at Metabolic Health Summit in January of 2024, Chad shares his journey of becoming metabolically, physically, and mentally elite in the fight against cancer.Through his deeply personal...2025-01-1442 minThe Metabolic LinkJournal Club: The Ketogenic Diet Reshapes Cancer Metabolism & the Gut Microbiome | Ep.58Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here. In this journal club episode, host Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping ca...2024-12-311h 11The Metabolic LinkThriving Beyond Schizophrenia: A Story of Healing with Metabolic Therapy | Lauren Kennedy West | Ep.57Join our free Live Q&A with Lauren on December 18th and become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Register here!In this episode of The Metabolic Link, host Victoria Field sits down with Lauren Kennedy West, a passionate mental health advocate and social worker who was diagnosed with schizoaffective disorder in 2016. Lauren reveals her extraordinary journey of using metabolic therapy to not only manage but reverse debilitating symptoms, transforming her life in ways she once thought impossible.This deeply compelling conversation delves into Lauren’s personal st...2024-12-161h 02The Metabolic LinkThe Science of Allulose | MHS Panel Discussion | The Metabolic Link Ep.56Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this special episode of The Metabolic Link, we’re sharing an exclusive panel discussion from Metabolic Health Summit 2024, where leading experts dive into the science and real-world applications of allulose, a natural low-calorie sweetener with potential metabolic health benefits.Featuring insights from Dr. Richard Johnson, Dr. Jeff Volek, Dr. Ben Bikman, Dr. Andrew Koutnik, and Dr. Dominic D’Agostino, this conversation explores how allulose influences glucose levels, insulin sensitivity, weight management, and GLP-1 stimulation for sati...2024-12-1059 minThe Metabolic LinkFasting Mimicking Diet cycles, longevity and age-related diseases | Valter Longo, PhD | The Metabolic Link Ep.55Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Your first 7 days are free! PLUS use code blackfriday at checkout to receive 50% off your first 3 months (through November 29th): https://membership.metabolicinitiative.com In this episode of The Metabolic Link filmed at Metabolic Health Summit 2024, Dr. Valter Longo shares his latest research on the fasting mimicking diet (FMD) and its powerful impact on aging, metabolic diseases, and cancer treatment. With a focus on periodic fasting interventions, Dr. Longo highlights the role of FMD in activating stem cells, enhancing cellular repair mechanisms...2024-11-261h 14The Metabolic LinkThe Clinical Impact of Ketogenic Therapy in Epilepsy & Mental Illness | Beth Zupec-Kania, RDN, CD | The Metabolic Link Ep.54Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs. Your first 7 days are free! PLUS use code blackfriday at checkout to receive 50% off your first 3 months (through November 29th): https://membership.metabolicinitiative.comIn this episode of the Metabolic Link podcast, we are joined by Beth Zupec-Kania, an experienced dietitian and nutritionist with over 30 years in the field of ketogenic metabolic therapy. Beth has played a pivotal role in the development and implementation of ketogenic diets for the treatment of epilepsy, and her work has expanded to include a variety of...2024-11-1959 minThe Metabolic LinkTesting the Lipid Energy Model: Oreos vs Statins | Nick Norwitz, PhD | The Metabolic Link Ep. 53Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode, we're sharing a presentation from Metabolic Health Summit 2024 that dives into a groundbreaking experiment titled "Oreo vs. Statin," by researcher-educator Nick Norwitz, PhD. What started as a personal journey with metabolic health turned into a captivating exploration of the lipid energy model and lean mass hyper responders. Dr. Norwitz shares the dramatic results of his unorthodox study, where a diet consisting primarily of Oreos led to a jaw-dropping 70% reduction in LDL cholesterol. We discuss the...2024-11-0723 minThe Metabolic LinkFoodFight USA: The Battle Against Ultra-Processed Foods | Todd Wagner | The Metabolic Link Ep.52Did you know that nearly 60% of the average American's diet is made up of ultra-processed foods? This staggering statistic highlights a growing public health crisis linked to rising obesity rates and chronic diseases, not only in adults but our children too.In this week’s episode of The Metabolic Link, we dive into a critical conversation with Todd Wagner, a passionate advocate for food safety and health reform. As the founder of FoodFight USA, Todd is dedicated to cleaning up America’s tainted food supply and empowering consumers by raising awareness about the dangers of ultra-processed foods. He i...2024-10-221h 18The Metabolic LinkJournal Club: Metabolic Overdrive in Bipolar Disorder | The Metabolic Link Ep.51Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.We discuss how this groundbreaking research li...2024-10-0859 minThe Metabolic LinkC15: The Essential Fatty Acid Transforming Metabolic Health & Aging | Dr. Stephanie Venn-Watson | Ep.50In our 50th episode of The Metabolic Link podcast, host Dr. Dominic D’Agostino dives deep into the fascinating world of metabolic health through an unexpected lens — bottlenose dolphins. Dr. Stephanie Venn-Watson, a veterinary epidemiologist and public health scientist, joins the show to share her groundbreaking research with the U.S. Navy’s Marine Mammal Program, where dolphins helped reveal the essential role of C15:0. C15:0 is an odd-chain saturated fatty acid that has 3-times more cellular benefits than omega-3s. Dr. Venn-Watson surprisingly discovered that C15:0 (also called pentadecanoic acid) is an essential fatty acid - the fi...2024-09-241h 07The Metabolic LinkJeff Volek, PhD, RD | Exploring the Keto-Adapted Phenotype: Focus on Muscle | The Metabolic Link Ep.49Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of The Metabolic Link, recorded at Metabolic Health Summit 2024, we share Dr. Jeff Volek's full presentation where he takes a deep dive into the "Keto-Adapted Phenotype" with a focus on muscle. Dr. Volek, a leading expert in low-carbohydrate and ketogenic diets, shares groundbreaking research on how ketones impact muscle function and performance. Dr. Volek explores the intricate ways ketones influence muscle glycogen metabolism, ketone production in skeletal muscle, and even heart function.Dr...2024-09-1051 minThe Metabolic LinkNick Norwitz, PhD | The Future of Medicine & Metabolic Health | The Metabolic Link Ep.48Join Dr. Norwitz for a Live Q&A on September 10th at 12pm PT/3pm ET on The Metabolic Initiative platform! Visit this link to register, and also watch his presentation Cookies & Cholesterol Controversy inside the platform (first 7-days are free): https://membership.metabolicinitiative.com/norwitzIn this episode, Dr. Nick Norwitz returns to The Metabolic Link podcast to explore the future of personalized medicine and the evolution of metabolic health research with host, Dr. Dominic D’Agostino. Join us as they dive into the landscape of traditional randomized control trials, the rise and evolution of individualized he...2024-08-271h 19The Metabolic LinkDr. Chris Palmer | Brain Energy: The Metabolic Theory of Mental Illness | The Metabolic Link Ep. 47Become a member of The Metabolic Initiative to access a robust bank of cutting edge metabolic health content, private ad-free podcast episodes, and earn CMEs here!More than a billion people around the world suffer from mental and neurological disorders, and the numbers are escalating rapidly. Current treatments often fail to provide relief, resulting in many patients struggling with persistent symptoms and resistance to available therapies.In this episode, we’re sharing a full presentation by world-renowned Harvard Psychiatrist, Dr. Christopher Palmer, filmed at Metabolic Health Summit 2024. Dr. Palmer presents a novel perspective that examines th...2024-08-131h 04The Metabolic LinkInfections, Inflammation, and Alzheimer's Disease with Mary Newport, MD | The Metabolic Link Ep.46Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here!In this enlightening episode of The Metabolic Link, Dr. Dominic D'Agostino sits down with Dr. Mary Newport to delve into the world of Alzheimer's disease, discussing her pioneering work with ketogenic metabolic therapy. Dr. Newport shares her personal and inspiring journey with her husband, Steve, whose battle with early-onset Alzheimer's led her to discover the life-changing effects of MCT and coconut oil. Dr. Newport also explores the crucial role of nutrition in managing Alzheimer's, the potential of exogenous ketones, and the...2024-07-302h 07The Metabolic LinkMetabolic Therapy for Serious Mental Illness | Dr. Deanna Kelly, Pharm.D., BCPP | The Metabolic Link Ep.45Become a member of The Metabolic Initiative for ad-free episodes and CMEsIn this episode of The Metabolic Link, host Victoria Field interviews Dr. Deanna Kelly, a distinguished professor of psychiatry at the University of Maryland School of Medicine. Dr. Kelly is pioneering nutritional interventions to treat serious mental illness and led a groundbreaking trial on the ketogenic diet for schizophrenia, the only inpatient study of its kind in the U.S. Unfortunately, this privately funded trial was recently shut down by the Maryland Department of Health. This interview was recorded before this development.Despite...2024-07-1658 minThe Metabolic LinkDr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of the Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International...2024-07-0257 minThe Metabolic LinkTake Control of Your Metabolic Health with Dr. Casey Means | The Metabolic Link Ep. 43Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this interview, host Victoria Field sits down with Dr. Casey Means, a Stanford-trained physician, entrepreneur, and New York Times bestselling author of the new book Good Energy. Dr. Means shares her inspiring journey from being a head and neck surgeon to leaving traditional medicine and becoming a leading voice in the metabolic health field. They take a deep dive into the environmental factors that impact our metabolism, the importance of taking care of your mitochondria, and practical steps...2024-06-181h 15The Metabolic LinkLily Nichols, RDN, CDE | Optimizing Pregnancy and Metabolic Health | The Metabolic Link Ep.42Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs! Registered dietitian, Lily Nichols, RDN, CDE, is back on The Metabolic Link, this time in an intimate interview that dives into the critical links between metabolic health, perinatal nutrition, and long-term wellbeing. This episode dives deep into how nutrition during the childbearing years can affect not only mothers but their children throughout their lives.Lily, who is also a New York Times bestselling author of key books on prenatal nutrition, unpacks the significance of blood sugar balance, the role of various micronutrients, and...2024-06-0421 minThe Metabolic LinkMitochondrial Health and Urolithin A with Dr. Anurag Singh | The Metabolic Link Ep. 41Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs!Join us in this enlightening episode as we dive deep into the emerging research behind Urolithin A and its impact on mitochondrial health with Dr. Anurag Singh, a leading expert in the field and the Chief Medical Officer of Timeline.The discussion spans various facets of Urolithin A, from its origin in pomegranates and other foods to its potential in improving mitochondrial health, muscle strength, and reducing inflammation. Dr. Singh shares insights from his decade-long research on this remarkable compound, discussing...2024-05-2153 minThe Metabolic LinkDr. Nina Teicholz | Beyond the Diet Wars: A Deep Dive into Nutrition Science | The Metabolic Link Ep.40Become a member of The Metabolic Initiative for exclusive episodes and earn CMEs! Dive into the core of nutrition science with Dr. Dominic D'Agostino and Dr. Nina Teicholz, and uncover the remarkable benefits of saturated fats, unravel the complexities of LDL cholesterol, and dig into the heated debate surrounding food addiction and ethical meat consumption. Dr. Teicholz sheds light on the misunderstood facets of dietary fats, debunking prevalent myths about cholesterol, highlighting potential detrimental effects of seed oils, and offering profound insights into how adherence to outdated dietary guidelines impacts both our health and the...2024-05-071h 08The Metabolic LinkA Biological Switch that Drives Obesity, Diabetes, and Dementia with Richard Johnson, MD | The Metabolic Link Ep. 39Become a member of The Metabolic Initiative for exclusive episodes and to earn CMEsIn this episode, recorded at Metabolic Health Summit 2024, Dr. Richard Johnson dives into the groundbreaking research that has uncovered the central role of fructose in driving the epidemics of obesity, diabetes, and a wide range of other metabolic diseases.Dr. Johnson presents compelling evidence that fructose, a seemingly innocuous sugar, is in fact a key trigger for activating a powerful biological survival switch. This switch, evolved in nature to help animals prepare for times of scarcity, is now being inadvertently activated...2024-04-2355 minThe Metabolic LinkJournal Club: Exploring Immune Response to Diet: Vegan vs Ketogenic Ep. 38In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The host...2024-04-0950 minThe Metabolic LinkBioMolecular Athlete: Advanced Tools For Enhanced Human Performance with Andy Galpin, PhD | The Metabolic Link Ep. 37The following Metabolic Link episode was originally filmed at Metabolic Health Summit 2024 and we're excited to share it with you today in its entirety! In this presentation, Dr. Andy Galpin, a human performance scientist, shares his insights on utilizing scientific principles, specifically the 'Biomolecular Athlete' concept, to achieve athletic excellence. He emphasizes the importance of individualized strategies that consider sleep, diet, stress, respiratory rates, and blood chemistry.The discussion then progresses to the groundbreaking future of human performance, including the use of digital twins for simulating and optimizing individual health outcomes, and the exploration of advanced technologies...2024-03-261h 29The Metabolic LinkKetogenic Diet’s Impact on Health and Performance with Jeff Volek, PhD | The Metabolic Link Ep. 36This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Jeff Volek, a professor at The Ohio State University. With a PhD in Kinesiology specializing in exercise and nutrition science from Penn State University, Dr. Volek has performed cutting edge research on how humans adapt to diets restricted in carbohydrates with a dual focus on clinical and performance applications of nutritional ketosis. His scholarly work includes more than 300 peer-reviewed scientific manuscripts and five books, including a New York Times Best Seller.In this wide-ranging interview, we cover:💡 Unexpected normalization of muscl...2024-03-0422 minThe Metabolic LinkFat: Why it Matters and What to Do About It with Ben Bikman, PhD | The Metabolic Link Ep. 35This week's episode of The Metabolic Link features a full presentation from Metabolic Health Summit 2024. Dr. Ben Bikman, professor at Brigham Young University, dives deep into the intricacies of fat and its relationship to metabolic health.This is the full presentation he delivered at Metabolic Health Summit 2024 in Clearwater Beach, Florida. In it he shares his expertise on the link between body fat, insulin resistance, and chronic diseases such as obesity and diabetes. Throughout this talk, he covers:💡 The role of insulin in regulating obesity and diabetes, and its direct correlation with maintaining fat mass.2024-02-2644 minThe Metabolic LinkChange Your Diet, Change Your Mind: Ketogenic Therapy for Mental Health with Dr. Georgia Ede | The Metabolic Link Ep. 34This week’s episode of The Metabolic Link features an illuminating sit-down interview with Dr. Georgia Ede, a Harvard-trained psychiatrist specializing in nutrition science and brain metabolism. With over 25 years of clinical experience, including 12 years as a college psychiatrist and nutrition consultant at Smith College and Harvard University Health Services, Dr. Ede was the first to offer students nutrition-based approaches as an alternative to psychiatric medications. She speaks internationally about using dietary therapies for psychiatric disorders, co-authored the first inpatient study of the ketogenic diet for treatment-resistant mental illness, and developed the first accredited course on ketogenic diets for me...2024-02-1417 minThe Metabolic LinkRecapping Metabolic Health Summit 2024 with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria FieldIn this episode of The Metabolic Link, Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field recap Metabolic Health Summit 2024, the world’s leading medical and scientific conference on metabolic health. Listen to this episode to get an inside look at the top scientific highlights and surprising moments from the perspective of the hosts who made it happen.Want to learn about all the cutting-edge research and scientific insights on metabolic health and therapy that you won’t find anywhere else? We recorded the entirety of Metabolic Health Summit 2024 and you can still watch the replay, but th...2024-02-0625 minThe Metabolic LinkUnderstanding The Lean Mass Hyper Responder w/ Dr. Nick Norwitz and Dave Feldman | The Metabolic Link Ep. 32We’ve just launched an extra and exciting episode of The Metabolic Link podcast! It features an eye-opening conversation between our host Dominic D’Agostino PhD, and guests Dave Feldman and Dr. Nick Norwitz, two researchers and MHS 2024 speakers spearheading investigations into the lean mass hyperresponder (LMHR) phenotype.Dave Feldman is a software engineer who became deeply interested in lipidology after seeing his cholesterol spike on a low-carb, high-fat diet. He has since performed self-experiments and published several papers on the possible mechanisms behind LMHR. He is currently conducting a clinical study out of UCLA through his newl...2024-01-121h 07The Metabolic LinkMetabolic Consequences of Disrupted Sleep w/ Dr. Jonathan Jun | The Metabolic Link Ep. 31This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D’Agostino and Dr. Jonathan Jun, a pulmonary critical care and sleep medicine physician at Johns Hopkins.He is an expert in the diagnosis and treatment of sleep-disordered breathing, and in the care of critically ill patients in the Medical ICU. He is a member of the Sleep Fellowship Program Evaluation and Clinical Competency Committee and provides teaching to medical students and residents at Johns Hopkins.In this episode, we cover:💡 Defining obesity hypoventilation syndrome (OHS) and its...2024-01-0948 minThe Metabolic LinkHow Allulose Aids Metabolism & Fructose Fuels Cancer | Journal Club | The Metabolic Link Ep. 30In this episode, our co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field discuss two recent scientific papers on the metabolic effects of allulose and how blocking fructose intake may help fight cancer.The first paper examines how allulose consumption influences metabolic factors like appetite, blood sugar, and insulin sensitivity through the release of key gut hormones and effects on carbohydrate digestion and metabolism.The second paper reviews multiple lines of evidence linking fructose metabolism to driving cancer progression. High fructose intake may directly supply tumors with fuel and biomolecular building blocks to gr...2023-12-1954 minThe Metabolic LinkOptimizing Metabolic Health After Cancer Diagnosis w/ Chad Vanags | The Metabolic Link Ep. 29This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dom D’Agostino and Chad Vanags, a successful entrepreneur who is navigating a stage 4 cancer diagnosis with courage and purpose.After being diagnosed with stage 4 lung cancer in 2022 at just 39 years old, Chad has been documenting his journey to becoming “metabolically, physically, and mentally elite” to continue pursuing his life's vision.In this wide-ranging discussion, we cover:💪 Chad's backstory as a thriving entrepreneur before his "unlucky" diagnosis💪 His shift in mindset after being told he has just months le...2023-12-051h 11The Metabolic LinkKeys To Making The Ketogenic Diet Work In The Real World w/ Franziska Spritzler | The Metabolic Link Ep. 28This week’s episode of The Metabolic Link features an illuminating conversation between our host Dominic D'Agostino, PhD, and Franziska Spritzler, RD, CDE.Franziska is a registered dietitian and certified diabetes educator who specializes in low-carb and ketogenic diets. She has been following a low-carb approach for over a decade.In this episode, we cover:💡 The essential tools Franziska uses when helping clients adhere to low-carb diets💡 Managing and interpreting changes in blood work on low-carb diets💡 Tips for navigating low-carb and ketogenic diets when traveling or eating out💡 Fran...2023-11-2255 minThe Metabolic LinkMood + Mindfulness | Journal Club | The Metabolic Link Ep. 27In this episode, our co-hosts Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff discuss two recent scientific papers on the potential metabolic connections to psychiatric disorders and mindfulness-based interventions.The first paper is a systematic review on the efficacy of low-carb and ketogenic diets for treating mood and anxiety disorders. They discuss the importance in defining what constitutes a low-carb or ketogenic diet in research studies. Our hosts also discuss the limited data available, with only 12 studies meeting the criteria for inclusion. However, the review indicates some positive preliminary findings for the use of these diets...2023-11-061h 05The Metabolic LinkThe Six Pillars of Health | Dr. Kyle Gillett | The Metabolic Link Ep. 26This week’s episode of The Metabolic Link features an illuminating conversation between our host Dr. Dominic D'Agostino and Dr. Kyle Gillett, a board-certified physician in family and obesity medicine who provides holistic care to his patients.He earned his medical degree at the University of Kansas School of Medicine, practices at the Gillett Health Clinic in Olathe, Kansas, and is the host of The Gillett Health Podcast. His practice focuses on preventive, integrative, and precision medicine approaches, with expertise in hormone and metabolic optimization.In this wide-ranging discussion, we cover:Using genotyping and ph...2023-10-241h 25The Metabolic LinkEvidence-Based Prenatal Nutrition | Lily Nichols | Metabolic Link Ep. 25This week's episode of The Metabolic Link features an eye-opening discussion between Metabolic Health Summit organizer Victoria Field and prenatal nutrition expert Lily Nichols, RDN, CDE. Lily is the author of two bestselling books - Real Food for Pregnancy and Real Food for Gestational Diabetes. Her work focuses on evidence-based, critical analysis of conventional pregnancy nutrition recommendations.In this episode, we cover:Evaluating macronutrient needs in pregnancy, including research suggesting carbohydrate intake recommendations may be set too high, and protein intake targets too lowThe use of nutritional ketosis in pregnancyThe latest research on preventing gestational diabetes...2023-10-101h 02The Metabolic LinkThe Emerging Field of Metabolic Psychiatry | Dr. Shebani Sethi | Metabolic Link Ep. 24In this week’s episode of The Metabolic Link, double board certified psychiatrist and obesity medicine physician, Dr. Shebani Sethi, takes us on a deep dive into the emerging field of metabolic psychiatry.Dr. Shebani Sethi is a psychiatrist and obesity medicine physician at Stanford University School of Medicine. She is the founding director of the Stanford Metabolic Psychiatry Clinic, where she researches dietary and pharmacological interventions to improve metabolic health and mental illness. Her background and expertise in integrating low carbohydrate nutrition with psychiatric care has created the foundation for Dr. Sethi to effectively treat patients ba...2023-09-2808 minThe Metabolic LinkMetabolic Interventions For Cognitive Resilience in Aging | Abbi Hernandez, PhD | The Metabolic Link Ep. 23This week’s episode of The Metabolic Link features an illuminating conversation between our host Dominic D’Agostino, PhD, and Dr. Abbi Hernandez, an assistant professor at the University of Alabama at Birmingham.Dr. Hernandez received her PhD from the University of Florida, where she studied age and diet related changes in neurological function and cognitive health. Her research has focused on investigating the potential of ketogenic diets and time-restricted feeding for preventing age-related cognitive decline. Recently, she has been exploring the gut-brain axis.In this episode, we cover:The importance of the hippocampus for...2023-09-1355 minThe Metabolic LinkThe Metabolic Underpinnings of Bipolar Disorder | Iain Campbell, PhD & Matt Baszucki | The Metabolic Link Ep. 22In this week’s episode, host Victoria Field speaks with Matt Baszucki and Dr. Iain Campbell about their lived experiences with bipolar disorder and the therapeutic effects of the ketogenic diet, potential root causes of the mental illness, and their mission to spread awareness and education around ketogenic dietary therapy as a treatment for bipolar disorder.Iain Campbell, PhD, is the Baszucki Research Fellow in Metabolic Psychiatry at the University of Edinburgh. He has a PhD in Global Health from the University of Edinburgh and is a principal investigator on a pilot trial of a ketogenic diet fo...2023-08-291h 10The Metabolic LinkWarburg Effect in Sporadic Alzheimer's & Ketogenic Therapy for MS Patients | Journal Club | The Metabolic Link Ep. 21In this episode, our co-hosts Victoria Field, Dominic D’Agostino, PhD, and Angela Poff, PhD, discuss two recent scientific studies that focus on the potential metabolic connections to neurodegenerative diseases.Study 1: Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s diseaseThe study delves into the molecular changes causing a neuron's transition from healthy to degenerative, as seen in sporadic Alzheimer's, which is the most prevalent form of Alzheimer's disease and isn't directly inherited but arises from a mix of genetic and environmental factors. It proposes that metabolic changes in neurons due to altered gene...2023-08-161h 20The Metabolic LinkDr. Jeff Volek, PhD, RD | Ketogenic Diet and Human Performance | The Metabolic Link Ep.20This week’s episode of The Metabolic Link features an in-depth conversation between our host Dominic D’Agostino, PhD, and Jeff Volek, PhD, RD, on a wide range of topics as well as questions submitted by our Twitter followers!Dr. Volek is a registered dietitian and professor in the Department of Human Sciences at The Ohio State University. For the last 25 years, he has performed translational research on how humans adapt to ketogenic diets with a dual focus on clinical and performance applications of nutritional ketosis.In this episode, we cove...2023-07-311h 15
The Metabolic LinkKetogenic Therapy for Epilepsy | Kelly Faltersack MS, RDN, LDN, CD | The Metabolic Link Ep.19On this week’s episode of The Metabolic Link, our host and MHS Co-organizer Victoria Field interviewed Kelly Faltersack, a registered dietitian nutritionist, who specializes in treating patients with ketogenic diet therapy as an effective treatment for epilepsy and other neurological disorders.Kelly Faltersack MS, RDN, LDN, CD is a registered dietitian nutritionist at UW Health in Madison, Wisconsin. Kelly has over 10 years of experience as a registered dietitian nutritionist, and five years of experience in neuro intensive care. She has specialized in ketogenic metabolic therapy for adults with epilepsy and other neurological conditions since 2016. Kelly has co...2023-07-1946 minThe Metabolic LinkSatchin Panda, PhD | Circadian Rhythm and Metabolic Health | The Metabolic Link Ep.18This week’s episode of The Metabolic Link features an enlightening conversation between our host Dr. Dominic D’Agostino and Dr. Satchin Panda, PhD on the fascinating connection between time-restricted eating, circadian rhythm, and metabolic health. A leading expert in the field of circadian rhythm research, Dr. Panda is a professor at the Salk Institute for Biological Studies and a founding executive member of the Center for Circadian Biology at the University of California.Have you been hearing lately about the importance of morning light exposure?2023-07-0528 minThe Metabolic LinkKetogenic Therapy for Mental Illness | Nicole Laurent, LMHC | The Metabolic Link Ep.17This week’s episode of The Metabolic Link features an interview with Nicole Laurent, a Licensed Mental Health Counselor who helps her clients use ketogenic dietary therapy as a treatment for mental illness and neurological issues. Nicole was one of seven pioneers of Metabolic Psychiatry recognized by the Baszucki Brain Research Fund and the Milken Institute with the Metabolic Mind Award in 2022.What is Metabolic Psychiatry?Metabolic psychiatry is an emerging field that focuses on targeting and treating metabolic dysfunction to improve mental health outcomes. There is growing evidence of a connection between me...2023-06-201h 12The Metabolic LinkThe Impact of Hyperglycemia in Stroke and Aerobic Exercise in Alzheimer’s | The Metabolic Link Ep.16In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field review recent research uncovering the potential impact of high blood glucose on stroke outcomes and the positive influence of exercise on Alzheimer’s disease.An ischemic stroke happens when a blood vessel in the brain is occluded. This prevents oxygen and nutrients from reaching a region of the brain, ultimately causing some of that tissue to die. A hemorrhagic stroke occurs when a blood vessel bursts and causes bleeding into the brain, and is a less common but ofte...2023-06-0648 minThe Metabolic LinkThe Metabolic Management of Migraines | Elena Gross, PhD | The Metabolic Link Ep. 15It’s said that more than one billion individuals around the world suffer from migraines each year. A migraine isn’t your average headache. It’s often completely debilitating and may include sensitivity to light and sound, vomiting, severe pain, and other symptoms that can wreak havoc on quality of life. Despite being one of the most common neurological disorders on the planet with a high prevalence in (particularly female) young adults, many of those troubled by migraines do not receive effective care and continue to suffer.Lack of tolerable and efficacious treatment options is exactly what led ou...2023-05-2355 minThe Metabolic LinkKwadwo Kyeremanteng, MD | An ICU Perspective on Metabolic Health | The Metabolic Link Ep.14On this episode of The Metabolic Link, we’re sitting down with Dr. Kwadwo Kyeremanteng to discuss his experience as a critical care physician during 2020, the importance of metabolic health in fighting viral infections, and how improving global metabolic health will make us more resilient against future illnesses.Dr. Kyeremanteng is an ICU doctor and intensivist at The Ottawa Hospital who seeks to increase the efficiency of medical care with cost-effectiveness, dignity, and justice in mind while also seeking solutions to improve healthcare delivery and practitioner wellness. As a researcher, he is interested in using ICU resources mo...2023-05-0910 minThe Metabolic LinkLight Exposure, Sleep Quality, & Cardiometabolic Function | Journal Club | The Metabolic Link Ep.13You won’t be surprised to hear that a night of poor sleep can affect how good you feel the next day. But did you know that disruptions in sleep quality, especially when they occur chronically, can have a major negative impact on your cognitive function, mood, and overall metabolic health?On this week’s Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field dive into two research publications exploring how meal timing in shift workers affects mood vulnerability and how light exposure during sleep impairs cardiometabolic function.T...2023-04-2539 minThe Metabolic LinkTommy Wood, MD, PhD | Optimizing Human Health & Cognition | The Metabolic Link Ep.12On this week’s episode of The Metabolic Link, host Dr. Dominic D’Agostino is sitting down with neuroscientist, Tommy Wood, MD, PhD, to discuss optimizing human health and cognitive function. In this interview, Dom explores a wide variety of fascinating topics with Dr. Wood. They uncover why cognitive demand may be important in preventing devastating neurological disorders like dementia, the importance of monitoring cardiovascular risk biomarkers including insulin, ApoB, homocysteine, and the potential benefit (or not) of using uric acid as a marker of health. They also explore the science of using the sauna, if Dr. Wood...2023-04-111h 55The Metabolic LinkJaime Seeman, MD | Women’s Metabolic Health Through the Life Stages | The Metabolic Link Ep.11On this week’s episode of The Metabolic Link, we’re sitting down with OBGYN and Ketogenic Metabolic Therapy Expert, Jaime Seeman, MD, to discuss the importance of metabolic health through a woman's life stages. In this interview, we explore how and why a woman might want to optimize their metabolic health in their fertile years, into menopause, and beyond. We also uncover the specific issues women can face along the way, the potential of metabolic therapy in improving hormone function, the unique differences between men and women's health, the future of precision medicine, and so much more!2023-04-0414 minThe Metabolic LinkKetosis in Models of Muscle Atrophy | Journal Club | The Metabolic Link Ep.10On this week’s Journal Club episode of The Metabolic Link, co-hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field discuss two seemingly conflicting research studies exploring the effects of ketosis on muscle health in models of atrophy.Atrophy refers to the wasting of a body tissue or organ that occurs due to the degeneration of cells. Atrophy of vital tissues such as the skeletal muscle occurs in numerous pathological catabolic conditions, such as in cancer cachexia, motor neuron diseases, and following ischemic events, and it contributes greatly to morbidity and mortality in these patients. But...2023-03-2842 minThe Metabolic LinkBen Bikman, PhD | Reversing Insulin Resistance | The Metabolic Link Ep.9On this week’s episode of The Metabolic Link, Dr. Dominic D’Agostino is sitting down with world-renowned metabolic scientist, Ben Bikman, PhD, to explore the ins and outs of insulin resistance, Type 2 Diabetes Mellitus (T2DM), and ways to manage, and even reverse, both.In this discussion, Dr. Bikman makes a case for why testing fasting insulin should be a part of the diagnostic and treatment equation when addressing T2DM, the difference between pathological and physiological insulin resistance, and how insulin therapy affects metabolic physiology in T2DM. Dr. Bikman explains that while insulin is nece...2023-03-211h 12The Metabolic LinkMetabolic Therapy for Parkinson’s & Mental Illness | Journal Club | The Metabolic Link Ep.8In this Journal Club episode, The Metabolic Link Hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field review recent research exploring the use of ketogenic metabolic therapy in Parkinson’s Disease and Mental Illness.The first study discussed investigates the effects of a ketogenic diet applied prior to versus after the onset of Parkinson’s disease in an animal model. Parkinson’s disease is a highly prevalent disease, with over 6 million people worldwide who suffer from it. We understand the fundamental feature of Parkinson’s disease is characterized by the loss of dopaminergic neurons, but researcher...2023-03-141h 00The Metabolic LinkL.J. Amaral, M.S., R.D., CSO | Implementing Metabolic Therapy for Cancer | The Metabolic Link Ep.7On this week’s episode of The Metabolic Link, we’re sitting down with Oncology Dietitian, L.J. Amaral for a fascinating conversation that explores implementing metabolic therapy, such as the ketogenic diet, within oncology. In this episode, we dive into why she started using metabolic therapy for cancer, how she implements it with patients at Cedars-Sinai, and the kind of results she’s seen in using it. We also cover some of the most difficult obstacles in starting a ketogenic diet in the face of a cancer diagnosis, and how Amaral helps patients overcome such challenges.L.J. A...2023-03-0742 minThe Metabolic LinkValter Longo, PhD | Fasting for Metabolic Health & Longevity | The Metabolic Link Ep.6On this week’s episode of The Metabolic Link, we’re sitting down with world-renowned Fasting and Longevity Researcher, Valter Longo, PhD, to explore a variety of topics related to metabolic health including the impact of protein consumption on longevity, the latest research on the fasting mimicking diet in diabetes and Alzheimer’s, the future of metabolic therapies, and how both our host of The Metabolic Link, Dr. Dominic D'Agostino, and Dr. Longo utilize fasting and approach healthy eating in their own lives. Dr. Valter Longo has thirty years of experience in the field of longevity and healthy...2023-02-281h 01The Metabolic LinkLucia Aronica, PhD | The Role of Epigenetics in Metabolic Health | The Metabolic Link Ep.5On this week's episode of The Metabolic Link, we’re sitting down with Longevity and Epigenetics Researcher, Lucia Aronica, PhD, to explore the science behind how our DNA and diet dance together to determine our metabolic health. We also dive into how nutrition affects our epigenetics, how an individual’s genetic makeup influences which diet is most suitable for them, and what biomarkers can be utilized to assess response to diet. Dr. Lucia Aronica, Ph.D., is Lecturer at Stanford University, Genomics R&D Lead at Metagenics Inc., and an acclaimed speaker in the field of personalized lifes...2023-02-2118 minThe Metabolic LinkMetabolic Therapy for Cancer | Journal Club | The Metabolic Link Ep.4In this week’s Journal Club episode of The Metabolic Link, hosts Dr. Dominic D’Agostino, Dr. Angela Poff, and Victoria Field explore metabolic therapy for cancer and why some researchers believe that the altered metabolism that drives tumor progression might be successfully targeted with novel metabolic focused approaches such as the ketogenic diet. They specifically review and evaluate a 2022 case study detailing the use of a calorie restricted ketogenic diet complementary to standard of care therapies in a patient with lung cancer that had metastasized to the brain. This emerging field of research is promising, but still in its...2023-02-1444 minThe Metabolic LinkMolly Maloof, MD | Optimizing Metabolic Health for Women | The Metabolic Link Ep.3On this week’s episode of The Metabolic Link, host Dr. Dominic D’Agostino sits down with Dr. Molly Maloof to explore the importance of metabolic health for women and how to optimize it. They dive into biotechnology, fasting, the ketogenic diet, hormone testing, and the importance of social connection for metabolic and mental wellbeing. They also dive into a common struggle many women face: trying to lose weight or improve health while under a lot of stress… and Dr. Maloof even shares her personal experience with it during the pandemic.Dr. Maloof has first-hand experience in transf...2023-02-0735 minThe Metabolic LinkChristopher Palmer, MD | Brain Energy Metabolism & Mental Health | The Metabolic Link Ep.2On today's episode of The Metabolic Link podcast, we're sitting down with Harvard Psychiatrist, Christopher Palmer, MD, to explore the common thread between brain energy metabolism and mental health. In this intimate interview, we dive into how Dr. Palmer became a pioneer in the field of metabolic psychiatry, the role of metabolic therapy in mental health and how its impacted the lives of his patients, and much more. Dr. Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health who has been advocating the use of the medical ketogenic diet in the treatment of...2023-01-3118 min