Shows
LEVELS – A Whole New Level#273 - How to track carbs, fat, and protein with AI and why | Josh Clemente & Dominic D'Agostino - (Replay)Not all calories are equal. Tracking your macronutrient intake, using AI capabilities, can help you improve your body composition, facilitate weight loss, and boost exercise performance. The three macronutrients are protein, fat, and carbohydrates, with fiber a subset of carbs. Josh Clemente & Dr. Dominic D'Agostino discuss the new macros-tracking feature in the Levels app, the purpose and importance of each macronutrient, how to use macros-tracking in conjunction with biomarker data to improve health and fitness, and how easy the app’s AI functionality is to use.Sign Up to Get Your Free Ultimate Guide to...2025-04-241h 43
The Metabolic LinkJournal Club: The Rise of Fatty Liver Disease and its Metabolic Roots | Ep.66Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs: https://membership.metabolicinitiative.comIn today's journal club episode, co-hosts of The Metabolic Link, Dr. Angela Poff and Dr. Dominic D'Agostino, unpack the startling rise of non-alcoholic fatty liver disease (NAFLD)—a silent epidemic affecting millions worldwide. Tune in as they break down groundbreaking new research revealing how NAFLD isn't just impacting adults, but alarmingly, children and adolescents too.You'll learn about the latest updates in terminology, such as Metabolic Dysfunction Associated St...2025-04-2358 minThe Metabolic LinkThe Metabolic Impact of GLP-1s on Obesity | Spencer Nadolsky, DO | Ep.65Join us for a FREE Live Q&A with Dr. Spencer Nadolsky on April 22nd at 9am PT / 12pm ET! Your first seven days are free, and as a member of The Metabolic Initiative, you’ll gain access to exclusive, ad-free episodes, hundreds of expert-led videos on metabolic health and therapy, CME opportunities, and more here!In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Spencer Nadolsky—board-certified obesity and lipid specialist, former NCAA heavyweight wrestler, and founder of Vineyard—to explore one of the most hotly debated and often mi...2025-04-1159 min
Optimal Protein Podcast with Vanessa SpinaHow Ketones Burn Fat & Protect Muscle: Dr. Dominic D’AgostinoTimeline: Get 10% off Mitopure, clinically proven to boost mitophagy. Go to timeline.com/vanessa. In this powerful episode of The Optimal Protein Podcast, host Vanessa interviews Dr. Dominic D’Agostino, one of the world’s leading researchers in ketogenic science and metabolic therapy. They dive into how ketones not only serve as a powerful fuel source but also act as metabolic signaling molecules that promote fat loss, protect muscle, and support whole-body health. Dr. D’Agostino shares why he personally pursues ketosis every day, how ketones interact with protein metabolism, and the key differen...2025-03-311h 28The Metabolic LinkThe Mitochondrial Link to Mental Illness | Ana Andreazza, PhD | The Metabolic Link Ep.63Mitochondria do more than power our cells—they may hold the key to understanding and treating mental illness.In this episode of The Metabolic Link, Dr. Dominic D’Agostino sits down with Dr. Ana Andreazza, a leading expert in mitochondrial health at the University of Toronto.Dr. Andreazza has pioneered research linking mitochondrial dysfunction to psychiatric disorders like bipolar disorder, utilizing groundbreaking 3D brain organoid models to study neurotransmission. She also leads research on mitochondrial transplantation, a potential game-changer in regenerative medicine.Join us as we explore how mitochondria influence mood, metabolism, and over...2025-03-111h 04The Metabolic LinkOptimizing Metabolic Health | MHS Panel Discussion | The Metabolic Link Ep. 62Become a member of The Metabolic Initiative to access exclusive ad-free episodes, 100s of videos on metabolic health, and earn CMEs here.What’s the best way to optimize metabolic health? In this powerhouse episode of The Metabolic Link, we bring together leading experts including Dr. Ben Bikman, Dr. Richard Johnson, Dr. Jonathan Jun, Dr. Nick Norwitz, and Dave Feldman from our Optimizing Metabolic Health Symposium filmed at Metabolic Health Summit 2024 and hosted by Dr. Dominic D'Agostino.In this discussion, you'll dive into some of the biggest questions in metabolism, including:What are the lo...2025-02-2737 minThe Metabolic LinkTargeting Cancer Metabolism: The Future of Oncology | Dr. Tomás Duraj | The Metabolic Link Ep. 61What if we could target cancer at its metabolic core? In this episode of The Metabolic Link, Dr. Dominic D’Agostino is joined by Dr. Tomás Duraj, a physician and cancer metabolism researcher working alongside Dr. Thomas Seyfried.Dr. Duraj is the lead author of a groundbreaking review on ketogenic metabolic therapy for glioblastoma, bringing together leading experts to explore how metabolic strategies could reshape cancer treatment.In this deep-dive conversation, they discuss the bioenergetics of cancer, the role of mitochondria, the Warburg effect, and why targeting glucose and glutamine metabolism may be the key...2025-02-111h 32The Metabolic LinkJournal Club: The Ketogenic Diet Reshapes Cancer Metabolism & the Gut Microbiome | Ep.58Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here. In this journal club episode, host Victoria Field is joined by Dr. Angela Poff and Dr. Dominic D’Agostino to dive into two groundbreaking studies shaping our understanding of metabolism and its role in health and disease. The team explores the nuances of a recent randomized controlled trial on ketogenic diets, free sugar restriction, and their effects on glucose tolerance, lipid metabolism, and the gut microbiome. Then, they tackle a cutting-edge study uncovering the molecular mechanisms of ketogenic diets in reshaping ca...2024-12-311h 11The Metabolic LinkThe Science of Allulose | MHS Panel Discussion | The Metabolic Link Ep.56Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this special episode of The Metabolic Link, we’re sharing an exclusive panel discussion from Metabolic Health Summit 2024, where leading experts dive into the science and real-world applications of allulose, a natural low-calorie sweetener with potential metabolic health benefits.Featuring insights from Dr. Richard Johnson, Dr. Jeff Volek, Dr. Ben Bikman, Dr. Andrew Koutnik, and Dr. Dominic D’Agostino, this conversation explores how allulose influences glucose levels, insulin sensitivity, weight management, and GLP-1 stimulation for sati...2024-12-1059 minThe Metabolic LinkJournal Club: Metabolic Overdrive in Bipolar Disorder | The Metabolic Link Ep.51Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here.In this journal club episode of The Metabolic Link, we explore the cutting-edge "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.We discuss how this groundbreaking research li...2024-10-0859 min
The Ripple Effect PodcastThe Ripple Effect Podcast (Dr. Dominic D'Agostino | Can Keto Cure & Help Your Health?)Dr. Dominic D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops & tests metabolic therapies, including alternative energy substrates and ketogenic agents for neurological disorders, cancer and wound healing. Dr. D'Agostino is one of the world's foremost experts on the ketogenic diet & metabolic health. Dr. D'Agostino has personally practiced the ketogenic diet for over a decade. His personal experiences along with his years of human and animal research, had led him to be one of the most respected voices & researchers in health & nutrition, and has been interviewed on some...2024-09-261h 11The Metabolic LinkC15: The Essential Fatty Acid Transforming Metabolic Health & Aging | Dr. Stephanie Venn-Watson | Ep.50In our 50th episode of The Metabolic Link podcast, host Dr. Dominic D’Agostino dives deep into the fascinating world of metabolic health through an unexpected lens — bottlenose dolphins. Dr. Stephanie Venn-Watson, a veterinary epidemiologist and public health scientist, joins the show to share her groundbreaking research with the U.S. Navy’s Marine Mammal Program, where dolphins helped reveal the essential role of C15:0. C15:0 is an odd-chain saturated fatty acid that has 3-times more cellular benefits than omega-3s. Dr. Venn-Watson surprisingly discovered that C15:0 (also called pentadecanoic acid) is an essential fatty acid - the fi...2024-09-241h 07The Metabolic LinkNick Norwitz, PhD | The Future of Medicine & Metabolic Health | The Metabolic Link Ep.48Join Dr. Norwitz for a Live Q&A on September 10th at 12pm PT/3pm ET on The Metabolic Initiative platform! Visit this link to register, and also watch his presentation Cookies & Cholesterol Controversy inside the platform (first 7-days are free): https://membership.metabolicinitiative.com/norwitzIn this episode, Dr. Nick Norwitz returns to The Metabolic Link podcast to explore the future of personalized medicine and the evolution of metabolic health research with host, Dr. Dominic D’Agostino. Join us as they dive into the landscape of traditional randomized control trials, the rise and evolution of individualized he...2024-08-271h 19The Metabolic LinkInfections, Inflammation, and Alzheimer's Disease with Mary Newport, MD | The Metabolic Link Ep.46Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs here!In this enlightening episode of The Metabolic Link, Dr. Dominic D'Agostino sits down with Dr. Mary Newport to delve into the world of Alzheimer's disease, discussing her pioneering work with ketogenic metabolic therapy. Dr. Newport shares her personal and inspiring journey with her husband, Steve, whose battle with early-onset Alzheimer's led her to discover the life-changing effects of MCT and coconut oil. Dr. Newport also explores the crucial role of nutrition in managing Alzheimer's, the potential of exogenous ketones, and the...2024-07-302h 07
Happy Habit Podcast# 429 - The prescription strength diet thats helping to fight disease - Dr Dominic D'AgostinoIn this episode I speak with Dr Dominic D'Agostino an associate professor at the Univesrity of South Florida. He's a cancer research scientist, author, podcast host and CEO of KetoSwiss.
We talk about the difference between keto diet and the therapeutic keto approach.
Why does Dr D'Agostino call keto a presctription strength diet, plus we hear the impact keto can make on cancer.
What are Dr Dominic's views on intermittent fasting.
What does he eat himself given he's on a ketogenic diet.Why our ancestors were right in...2024-07-2257 minThe Metabolic LinkDr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44Become a member of The Metabolic Initiative to access exclusive episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode of the Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International...2024-07-0257 min
The Clinician's Corner#1: Dr. Dominic D’Agostino: Mastering the Ketogenic Diet - Applications, & Clinical StrategiesThe ketogenic diet has surged in popularity over the last few years. According to data from the Food Information Council, 23 million Americans chose to follow a ketogenic diet in 2022, which is more than double the number from just 4 years prior (10 million in 2018). With this surge in popularity, however, comes a surge in criticism along with the adulteration of the original therapeutic principles that inevitably accompany a diet’s commercialization. It’s time to clear through the confusion and get to what the research is showing us. In this episode of the RWS Clinician’s Corner we are joined...2024-06-181h 16LEVELS – A Whole New Level#255 - Why you might be a lean mass hyper-responder if you go keto but have high cholesterol | Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’AgostinoA lean mass hyper-responder is someone with high LDL and HDL cholesterol and low triglycerides. They are often lean and healthy people who present with strange and alarming lipid numbers after going on the ketogenic diet. Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino discuss the LMHR phenotype, whether it’s a concern, whether it’s rare, the Oreo vs statin study, how exercise levels might play a role, and why more research is needed.
Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl
Levels helps you...2024-05-311h 40
Mind & MatterKetosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino | #158About the guest: Dominic D'Agostino, PhD is a researcher and professor at the University of South Florida, where his lab studies metabolism, human biology, and related subjects.Episode summary: Nick and Dr. D'Agostino discuss: ketosis and the ketogenic diet; effects of ketosis on diabetes, insulin resistance & metabolic health; effects on brain & mental health; relationship with exercise performance; cholesterol, LDL, triglycerides & other biomarkers; cancer; and more.*This content is never meant to serve as medical advice.* Support M&M if you find value in this content.* Full audio only version: [Apple Podcasts] [Spotify] [Elsewhere]2024-05-161h 40LEVELS – A Whole New Level#253 - What is insulin resistance and why does it matter? | Dr. Rob Lustig & Dr. Dominic D’Agostino - (Replay)Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnlLevels helps...2024-05-091h 17The Metabolic LinkDr. Nina Teicholz | Beyond the Diet Wars: A Deep Dive into Nutrition Science | The Metabolic Link Ep.40Become a member of The Metabolic Initiative for exclusive episodes and earn CMEs! Dive into the core of nutrition science with Dr. Dominic D'Agostino and Dr. Nina Teicholz, and uncover the remarkable benefits of saturated fats, unravel the complexities of LDL cholesterol, and dig into the heated debate surrounding food addiction and ethical meat consumption. Dr. Teicholz sheds light on the misunderstood facets of dietary fats, debunking prevalent myths about cholesterol, highlighting potential detrimental effects of seed oils, and offering profound insights into how adherence to outdated dietary guidelines impacts both our health and the...2024-05-071h 08LEVELS – A Whole New Level#252 - Why nutrition matters for brain health and how to modify your diet | Dr. Georgia Ede & Dr. Dominic D’Agostino - (Replay)The ketogenic diet is a low-carbohydrate, high-fat diet that has proven benefits for brain health. Research shows that the keto diet helps ease symptoms of some mental health conditions, including depression and bipolar disorder. But no diet, even keto, is one-size-fits all. Dr. Georgia Ede and Dr. Dominic D’Agostino discuss how diet and brain health are connected, how diet and gut health affect brain health, and how a ketogenic or other low-carbohydrate diets can be tailored to people’s specific needs.Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl...2024-04-251h 14LEVELS – A Whole New Level#251 - How to track your macros for fat loss and muscle gain | Josh Clemente & Dominic D'AgostinoNot all calories are equal. Tracking your macronutrient intake, using AI capabilities, can help you improve your body composition, facilitate weight loss, and boost exercise performance. The three macronutrients are protein, fat, and carbohydrates, with fiber a subset of carbs. Josh Clemente & Dr. Dominic D'Agostino discuss the new macros-tracking feature in the Levels app, the purpose and importance of each macronutrient, how to use macros-tracking in conjunction with biomarker data to improve health and fitness, and how easy the app’s AI functionality is to use.
Sign Up to Get Your Free Ultimate Guide to...2024-04-181h 47
Dhru Purohit ShowKilling and Starving Cancer Cells Using the Power of Ketogenic Diets, Metabolic Therapies, and Hyperbaric Oxygen Combined with Standard of Care with Dominic D'Agostino, Ph.D.This episode is brought to you by Cozy Earth, Maui Nui, and Lumebox.We’ve heard about Dr. Thomas Seyfried’s groundbreaking research and approach to cancer as a disease of metabolic dysfunction. Today’s guest was inspired by Dr. Seyfried’s metabolic approach and conducted his own research on brain cancer cells using ketone-based metabolic therapy and hyperbaric oxygen. His findings were mind-blowing!Today on The Dhru Purohit Podcast, Dhru sits down with Dr. Dominic D’Agostino to discuss his extensive research on brain cancer cells placed in ketosis and under the pressu...2024-04-151h 38The Metabolic LinkJournal Club: Exploring Immune Response to Diet: Vegan vs Ketogenic Ep. 38In this episode of The Metabolic Link, Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff dive into a fascinating new paper that compares the metabolic and immune impacts of ketogenic and vegan diets in humans.The study, titled “Differential Peripheral Immune Signatures Elicited by Vegan Versus Ketogenic Diets in Humans” takes a deep dive into the multi-omic effects of these two very different dietary approaches. The researchers found that just two weeks on a ketogenic diet significantly enhanced markers of adaptive immunity, while the vegan diet was associated with increased innate immune function.The host...2024-04-0950 min
Biohacking News by ZestologyBeyond Carbs: The Keto Evolution feat. Dr. Dominic D'Agostino #479 Are you still putting butter in your coffee? Does low-carb suit you? Are you keto, or is it more nuanced these days? Repeat guest alert: I last spoke to Dr. Dominic D'Agostino seven years ago and since then so much is changed in the Keto world. So I was interested to see how his perspective has evolved over the last seven years war he advises people now and how he's changed his own practices and diet. He is a brilliant and inspiring man in the health and wellness space. And he even works with astronauts!...2024-03-2536 min
Sports Science DudesEpisode 64 Navigating the Ketogenic Landscape with Dr. Dominic D'AgostinoUnlock the secrets of the ketogenic diet with Dr. Dominic D'Agostino as we navigate the nuances of ketogenic protocols, from their clinical roots in epilepsy treatment to their modern-day applications in enhancing athletic prowess and brain health. Whether you're a seasoned keto aficionado or simply curious about this high-fat lifestyle, you're in for a wealth of knowledge that could reshape your understanding of nutrition.Timeline (Episode 64)1:50 Dr. Dom has cows and gators in his backyard! His dogs have fought with gators. The mammals win! 3:45 Definition of Ketogenic Diet (KD)8:18 There are o...2024-02-2054 min