Shows
The Lab ReportThe Roseto EffectLongevity isn’t about adding years to your life- it’s about adding life to your years! We know there are many variables to health such as diet, movement, sleep, social connection, fresh air and sunlight. Each are important but some aren’t easily measured. The Roseto Effect reveals the surprising power of tight-knit communities, social bonds, and old-world traditions in shaping our health. Join us as we tell the story of a small town in Pennsylvania called Roseto. Can community be the ultimate medicine? Today on The Lab Report: 3:20 The story of Roseto 10:35 Parallel...2025-02-0424 min
The Lab ReportLaryngitis - Voice on VacationEver wonder what happens when your voice suddenly decides to take a vacation? In this episode, we explore the mysterious condition of laryngitis. From causes to symptoms, we can help you discover the best ways to recover and protect your voice. Whether you're dealing with laryngitis now or just curious about how it works, this episode will give you the answers you need. Tune in for all the insights into a silent struggle! Today on The Lab Report: 2:50 Patti lost her voice so we’re covering laryngitis 4:05 The anatomy of the voice box and po...2025-01-2221 min
The Lab ReportA Holiday Hodgepodge [Rebroadcast]When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you! On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas. Today on The Lab Report: 5:00 Kentucky Fried Christmas 7:00 The Christmas Pickle 8:55 Pooping lo...2024-12-2427 min
The Lab ReportSurviving Cold & Flu SeasonAs the days get shorter and the air turns crisp, cold and flu season sneaks in bringing sniffles, coughing, fatigue, and fever. It’s a time when germs spread easily, and our immune systems face a tough challenge. When you add holiday stress in the mix, it becomes even more important to boost your defenses, and optimize your immunity. In today’s episode, we offer tips to help you unlock your body’s natural defenses as we try to navigate cold and flu season. This podcast has everything you need to stay ahead of seasonal sickness so you ca...2024-12-1128 min
The Lab ReportSurviving Holiday StressThe holiday season is a time of joy, connection, and celebration – but to be honest, it can also be incredibly stressful. Between hosting dinners, finding the perfect gifts, managing finances, and navigating family dynamics, it’s easy to feel overwhelmed. The good news? You’re not alone and there are ways to reclaim the magic of the season without losing your sanity. In today’s podcast, we dive into the science of stress and how the vagus nerve holds the key to calm. Discover how breathwork, mindfulness, and gratitude can transform your holiday experience, helping you stay grounded...2024-11-2727 min
The Lab ReportWeathering the Storm: Community, Mental Health, and the Path to Recovery Post-Hurricane HeleneWhere to begin? It’s been a few weeks since you’ve heard from us – thank you so much for your amazing support and patience. As you may know, Hurricane Helene brought devastation to western North Carolina, eastern Tennessee, South Carolina, Georgia, and Florida. Genova Diagnostics is headquartered in the heart of Asheville, North Carolina. With that, it’s been a challenging few weeks. But the heroic efforts of many, and the resilient spirit of our team have us back up and running. Genova continues to support our local community- many of whom are still struggling and have lost everythi...2024-11-0426 min
The Lab ReportThis Podcast Will Give You HeartburnGastroesophageal reflux disease (GERD), or heartburn, is incredibly common as is the use of stomach acid suppressing medication. But what if there is far more to the story than stomach acid? There are many other factors to consider in a patient with heartburn. We are going to dive into the physiology of gastric acid, gastric hormonal signaling, and a slew of medications and foods that might be the real culprit. Are PPI’s over prescribed? Are we missing the picture? Tune in to find out. In today’s episode, we tackle some burning questions about GERD and try...2024-09-1728 min
The Lab ReportWhat are Nootropics?Occasionally, there are new and novel things introduced into the functional medicine and biohacker space that catch our attention. Lately, you might have heard a lot of people talking about the amazing health benefits of “nootropics,” but what are they? Coming from the name of the Greek word Nous (meaning “mind”), nootropics are medicines designed to improve cognitive function and protect the brain. Many of us could use a healthy dose of cognitive support to help us through our busy lives, but what is the truth about nootropics and where can we find them? In today’s episode, we...2024-09-0427 min
The Lab ReportAre We Really Talking About Artichokes?Ok, we know what you’re thinking…. Artichokes? Really? Yes really. It may seem a bit out of left field, but you’d be surprised at the many health benefits from either eating artichokes or taking an extract supplement. As a vegetable, it contains fiber, vitamins, minerals, and antioxidants. Extracts made from artichoke leaves, stems, and roots have been used as nutraceutical agents to support the GI tract, liver, and cardiovascular system. But why? In this episode, we peel back the layers of the artichoke – a very mysterious plant indeed. Is it possible to boost your health with arti...2024-08-2727 min
The Lab ReportMast Cell Activation Syndrome & Histamine [Rebroadcast]Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyperreactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused. In today’s episode, we focus on the ro...2024-08-2021 min
The Lab ReportDesulfovibrio - Friend or Foe?The gut microbiome harbors trillions of commensal organisms which play a central role in our health. This community is sometimes referred to as our hidden metabolic organ due to its immense impact. Our diet and lifestyle play an important role in feeding the microbiome and keeping the colonies in balance. Should we be concerned if any one bacterial colony overgrows? Today we discuss the commensal bacteria Desulfovibrio. Since this genus of bacteria can reduce sulfate and make hydrogen sulfide gas, overgrowth can have clinical implications. Listen in for more information on why you should care and what...2024-08-1323 min
The Lab ReportWhat the heck is mTOR?There are a lot of terms bantered about in the biohacker and longevity space. With that, you’ve likely heard of mTOR – mechanistic (mammalian) target of rapamycin. But what exactly is it? mTOR is a key regulator in your body’s metabolic and growth processes. It integrates various signals, including nutrients and growth factors, to control processes like protein synthesis, autophagy, and lipid metabolism. Because it regulates growth, dysregulation of mTOR has been implicated in various diseases, including cancer. In today’s episode, we simplify the science behind mTOR – mechanistic target of rapamycin. This crucial enzyme may be the key...2024-08-0624 min
The Lab ReportThe Multi-Omics Series Part 4: CBS and Transsulfuration [Rebroadcast]Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects. Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important an...2024-07-3026 min
The Lab ReportGlutathione - Things You Don't KnowMany of us have heard of glutathione and understand that it is a powerful antioxidant – but why? What is it? How does it work? Understanding the mechanisms of this crucial molecule can help you fully grasp its importance. Oxidative stress and the damage of free radicals underlie the aging process and many chronic conditions. There’s no greater tool to combat oxidative stress than glutathione. In today’s episode, we break down the science of glutathione and redox reactions. You will learn how glutathione works, how to support optimal levels, and how it connects to the methylation cycle...2024-07-2426 min
The Lab ReportCreatineCreatine is a powerhouse supplement known for enhancing muscle strength, endurance, and recovery. By boosting ATP production, it fuels muscles during intense workouts, leading to greater gains and faster progress. Beyond its skeletal muscle benefits, creatine supports cognitive function, fertility, sight, hearing, and just about every process in the body. Today we discuss creatine and its many health benefits. Whether you're an athlete striving for peak performance or someone simply looking to improve overall health and vitality, consider fueling your potential with creatine. Today on The Lab Report: 3:50 Creatine and methylation 6:00 How does the...2024-07-1623 min
The Lab ReportHerbs for Cellular Health & Longevity with Dr. Bill RawlsDr. Bill Rawls was a practicing OB/GYN physician for decades before his health began to suffer and he was faced with the limitations of modern medicine. Embarking on his own health journey, he dove headfirst into holistic and herbal therapies and found ultimate wellness. Dr. Rawls now teaches and writes extensively about the power of herbal medicine. He’s written several books including Suffered Long Enough, Unlocking Lyme, and his latest book The Cellular Wellness Solution. Dr. Rawls even started his own herbal supplement and wellness company called Vital Plan. In today’s episode, Dr. Bill Rawl...2024-07-0955 min
The Lab ReportIntegrative Sports Nutrition with Ian CraigIn the world of athletic performance, there are plenty of health experts. But none like Ian Craig. Ian Craig takes a holistic and very personalized approach. With his joint academic backgrounds in exercise physiology and nutritional therapy, and a long successful career as a British middle-distance runner and coach, he’s been developing the concept of integrative sports nutrition for the past 20 years. Today we speak with Ian Craig who lays out the case for personalized and holistic care when it comes to optimizing athletic performance. Through his Centre for Integrative Sports Nutrition in Scotland, he’s been...2024-07-0244 min
The Lab ReportPatti & Michael Discuss AI in HealthcareArtificial intelligence and machine learning is being leveraged in every facet of society to improve efficiency and drive innovation. Healthcare is no different. Language models, algorithms, machine learning, and more are being developed and used to help with education, behavior change, administrative tasks, predictive risk assessments, and at times, disease diagnosis. In today’s episode, we discuss areas where the healthcare industry is harnessing artificial intelligence. With such powerful technology at our fingertips, it is always important to take a pause to debate the exciting capabilities but also its limitations and biases. Today on The La...2024-06-2529 min
The Lab ReportAuto-Brewery SyndromeIs it possible to be drunk without drinking alcohol? Actually, yes. There is a condition called auto-brewery syndrome whereby an imbalance in your gut microbiome can ferment carbohydrates to create alcohol. Blood alcohol levels can get surprisingly high. Though this condition is thought to be rare, it might just be underdiagnosed. Patients are dealing with legal ramifications, social stigmas, and disbelief by friends, family, and physicians. Today we introduce the topic of auto-brewery syndrome to raise awareness that your gut microbiome can produce alcohol. We discuss how it occurs, how to diagnose it, and some strategies to...2024-06-1825 min
Health Gig439. Discussing a Balanced Microbiome with Dr. Patti Devers and Dr. Michael ChapmanTricia and Doro welcome Dr. Patricia Devers, Chief Clinical Officer at Genova Diagnostics and Dr. Michael Chapman, naturopathic doctor at Genova Diagnostics. During this conversation, the doctors discuss their journey with Genova and their invaluable contributions to medical research. Dr. Devers, driven towards burn out with conventional medicine, found a new purpose at Genova, while Dr. Chapman's background in naturopathic medicine led him to support Genova’s personalized approaches to treatment. Together, they emphasize Genova's unwavering commitment to uncovering the underlying causes of chronic illnesses through comprehensive, individualized healthcare and cutting-edge testing methodologies.
Throughout the conversation, they shed light on th...2024-06-1242 min
Health Gig439. The Nitty-Gritty of the Gut: Discussing a Balanced Microbiome with Dr. Patti Devers and Dr. Michael ChapmanTricia and Doro welcome Dr. Patricia Devers, Chief Clinical Officer at Genova Diagnostics and Dr. Michael Chapman, naturopathic doctor at Genova Diagnostics. During this conversation, the doctors discuss their journey with Genova and their invaluable contributions to medical research. Dr. Devers, driven towards burn out with conventional medicine, found a new purpose at Genova, while Dr. Chapman's background in naturopathic medicine led him to support Genova’s personalized approaches to treatment. Together, they emphasize Genova's unwavering commitment to uncovering the underlying causes of chronic illnesses through comprehensive, individualized healthcare and cutting-edge testing methodologies. Throughout the conversation, they sh...2024-06-1242 min
The Lab ReportFood Additives - Hidden in Plain SightFood labels can be very confusing. In fact, many of us completely ignore them. If you look at the ingredients in many processed foods, you’ve probably tried to pronounce some of the chemical compounds listed in the ingredients. The food industry adds chemicals to food to either enhance flavor and color, or to preserve shelf life. There are thousands of accepted food additives and some may have important health implications. In today’s episode, we discuss just a few additives you might want to keep an eye out for next time you go to the grocery stor...2024-06-1124 min
The Lab ReportBasil Seeds: The New Superfood with Shakira NiaziShakira Niazi is the founder of Basil Seed Works – an organic basil seed product line featuring the superfood ZenBasil. As a refugee from war-torn Afghanistan who was later raised and educated in the US, Shakira’s path to becoming an entrepreneur is remarkable. Although she’s known for her work with Vita Water – helping to solve the world water crisis and providing water points to poor villages around the world, her current focus is to bring basil seeds from the Far East to the Western world. Basil seeds are a natural source of fiber, omega-3 fatty acids, vitamins, minerals, and anti...2024-06-0438 min
The Lab ReportDr Stephanie Venn-Watson: Cellular Health with Fatty15Dr. Stephanie Venn-Watson dedicated her life to public health and veterinary epidemiology. In studying dolphins, she discovered the first essential fatty acid to be found in over 90 years – C15:0 (pentadecanoic acid). Dr. Stephanie’s discovery and further research on C15:0 has uncovered some amazing cellular health benefits and significant potential for disease prevention. With this knowledge, Dr. Stephanie pivoted and founded fatty15 - a company that produces the world’s first, and only science-backed, patented C15:0 supplement. In today’s episode, we speak with Dr. Stephanie Venn-Watson about her latest research into the newly discovered essential fatty acid C15...2024-05-2844 min
The Lab ReportThe Methylation Cycle: Deep CutsMethylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In a previous episode, we introduced the topic of methylation and the basics of this biochemical reaction. However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance. Today, we dive a bit deeper into the biochemistry of methylation and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Gen...2024-05-2126 min
The Lab ReportMetabolic Health = GOOD ENERGY with Dr. Casey MeansWe are honored to welcome Dr. Casey Means back to the show. She is not only a passionate advocate for metabolic health, but also a voice of reason amidst a broken healthcare system, a profound champion spreading the message of connectedness and fearlessness, and lastly a dear friend. Dr. Means’ new book “Good Energy – The Surprising Connection Between Metabolism and Limitless Health” is available now anywhere books are sold. In this episode, we talk to Dr. Casey Means about her new book “Good Energy” which outlines how to connect the dots in healthcare, the critical importance of metabolic he...2024-05-1452 min
The Lab ReportThe Methylation Episode!The word ‘methylation’ has become somewhat of a buzz word in functional and personalized medicine. We’ve mentioned it several times throughout many episodes of The Lab Report – hard to avoid since it’s involved in just about every biological process. In today’s episode, we finally hit the topic of methylation head on and dive into the methylation cycle itself. What is it? Why should you care? Although biochemistry can be intimidating, listen as we simplify and demystify the steps involved. You may find it helpful to refer to a Methylation Pathway Chart while listening to this one!2024-05-0732 min
The Lab ReportHolistic Mental Health with Everest GoldsteinEverest Goldstein is a board-certified Psychiatric Nurse Practitioner who is also certified in Functional Medicine and has an extensive background in integrative wellness interventions. She deeply cares about her patients and devotes her time to working closely with each of them to address their individual needs. Knowing the importance of the brain-body connection, Everest addresses the body as a whole to optimize health and wellness. In today’s episode, we dive into the root causes of mood disorders and psychiatric illness with Everest Goldstein. Everest discusses how nutrition, diet, and lifestyle can contribute to mental health and we...2024-04-2339 min
The Lab ReportThe Benefits of BerberineBerberine is an alkaloid compound that can be extracted from several plants. It is a widely used supplement in personalized medicine and is also beginning to get some traction within the conventional medicine space. Berberine is mainly used in the GI tract for its antimicrobial effects, but as it relates to gut health, that’s just the tip of the iceberg. What is even more fascinating is berberine’s vast systemic metabolic influences. In today’s episode, we dive into the wide array of berberine’s important effects. Not only on the gut, but also on detoxification systems...2024-04-0924 min
The Lab ReportHealthy Gut, Healthy Skin with Dr. Nigma TalibFor decades Dr. Nigma Talib has been helping patients using her clinical expertise in naturopathic medicine. Her contributions to the field are recognized globally. Dr. Nigma has authored best-selling books such as “Reverse the Signs of Ageing” and “Younger Skin Starts in the Gut.” She was one of the first pioneers to introduce vitamin supplements in the fashion industry and she’s responsible for the radiant, glowing skin of some of Hollywood’s most famous faces. In today’s episode, we are honored to meet Dr. Nigma Talib. We discuss her holistic approach to health and learn her skincare t...2024-04-0230 min
The Lab ReportA Thyroid Masterclass with Taylor Morgan Christie, PA-CTaylor Morgan Christie is a board-certified Physician Assistant, a registered dietitian nutritionist, and she’s double board certified in functional medicine through IFM and IFNA. So, it should come to no surprise that she can basically riff on any topic we throw at her. However, she has a special passion for treating thyroid disorders and helping her patients find whole wellness. She’s spent over a decade studying and mastering her clinical approach and today we learn all about it. On today’s episode, we talk all things thyroid with Taylor Morgan Christie, PA-C. Thyroid physiology, symptoms, medica...2024-03-2637 min
The Divorce RevolutionTWR 259: Personalized Health Testing: The Key to Healing Chronic Illness & Optimizing Health with Dr. Patti Devers & Dr. Michael Chapman The only way to know what’s happening in your body is to test it. If you’re looking for a more personalized approach to improving your health and wellness, listen up! I have an exciting solution to share that’s not only accessible from the comfort of your home, but truly life-changing (and vetted by me). In this episode of The Wellness Revolution, I’m joined by Patti Devers, DO, the Chief Clinical Officer at Genova Diagnostics, along with Michael Chapman, ND, Genova’s Director of Product Innovation. Genova Diagnostics is a specialty...2024-03-2146 min
The Lab ReportDr. Anna Lembke - The Dopamine Hit and Addiction [Rebroadcast]If you’ve seen the Netflix documentary “The Social Dilemma,” you’ll recognize today’s guest. Dr. Anna Lembke is an addiction specialist from Stanford University, a New York Times best-selling author, and was featured on that Netflix special. Addiction takes many forms – not only alcohol and illicit drugs, but also social media, exercise, shopping, and workaholism. But, where’s the line between habit and addiction? What can we do to reset our brain chemistry? In this episode, Dr. Lembke explains dopamine’s role in our brain’s reward system. We discuss addiction in its many forms, social media, and...2024-03-1930 min
The Lab ReportBoron!...actually never mind, not boron.Ok, well…. Today’s episode is a bit unique…. The intention was to discuss the important benefits of a trace mineral called boron. It is an important mineral, make no mistake. But, as we started recording, we got bored. Turns out talking about boron is kind of boring! So, we do hit the boron highlights, but then, in typical Patti & Michael fashion, we veer off into debate and discussion. The topic became the danger of misinformation by health influencers and how to remain skeptical. Today on The Lab Report: 3:10 Thirty seconds on boron 4:35 A dose of skepti...2024-03-1223 min
The Lab ReportThe Power of Custom Formulas with Dr. Lydia ThurtonGenova’s nutritional testing offers precision results and personalized recommendations to create a nutritional treatment plan for optimal health and wellness. But for patients and clinicians, this can seem overwhelming when there is a significant amount of nutritional need. In addition to dietary counseling, clinicians often reach for supplements. VitaminLab is a premier supplement company in Canada that can customize results from the NutrEval and Metabolomix+ into as few pills as possible to help with patient compliance. Dr. Lydia Thurton is a naturopathic physician who works with clinicians through VitaminLab to help them through the process. In to...2024-03-0526 min
The Lab ReportHot Takes: The Cayenne PodcastCayenne pepper, derived from the Capsicum annuum plant, is a fiery herb renowned for its intense heat and vibrant flavor. It contains a compound called capsaicin which is not only responsible for its spicy punch, but also numerous health benefits. Beyond its culinary uses, cayenne is highly regarded for its medicinal properties in gut health, pain relief, and even cardiometabolic disease. In today’s episode, we turn up the heat as we delve into the fiery world of cayenne. From its origins to its culinary and medicinal uses, we’ll uncover the secrets and surprising health benefits of t...2024-02-2829 min
The Lab ReportWhat We Don't Know About Hormones - Part 3Genova’s Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine. Today is part 3 of our series where we chal...2024-02-2023 min
The Lab ReportRed Meat & Heart Disease [Rebroadcast]Foods come in and out of favor all the time. Eggs are good for you… no wait, they are bad… nope, good again – let’s not even discuss butter! There are many disease correlations related to specific foods and literature continues to evolve. One such focus is on red meat and its correlation to cardiovascular disease. But why? Is all red meat bad? Can you eat red meat and not increase heart disease risk? What about it should cause concern? Interestingly, the answer lies in the microbiome’s ability to metabolize the carnitine in red meat into a metabolite called trim...2024-02-1323 min
The Lab ReportPatti & Michael On The Road at Metabolic Health SummitPatti & Michael are on the road! We recorded this unique episode from the Genova Diagnostics booth as a sponsor of the Metabolic Health Summit 2024 in Clearwater Beach, Florida. This conference brings together cutting-edge research, world-class speakers, and the leading experts in metabolic health. As you can imagine, Genova’s testing is a key element in getting to the root cause of metabolic disfunction and optimal health. The personalization of our testing and results can help guide therapeutic modalities that may not be so obvious. In today’s episode, you’ll hear Patti & Michael recorded live from the Genova...2024-02-0629 min
The Lab ReportHerbs for Cellular Health & Longevity with Dr. Bill RawlsDr. Bill Rawls was a practicing OB/GYN physician for decades before his health began to suffer and he was faced with the limitations of modern medicine. Embarking on his own health journey, he dove headfirst into holistic and herbal therapies and found ultimate wellness. Dr. Rawls now teaches and writes extensively about the power of herbal medicine. He’s written several books including Suffered Long Enough, Unlocking Lyme, and his latest book The Cellular Wellness Solution. Dr. Rawls even started his own herbal supplement and wellness company called Vital Plan. In today’s episode, Dr. Bill Rawl...2024-01-3055 min
The Lab ReportThe Hormone Shift with Dr. Taz BhatiaDr. Taz Bhatia is a conventionally trained physician who has always been way ahead of her time. For years she’s been combining the best of modern science with eastern medical wisdom to help patients get to the root cause of chronic disease. As one of the OGs in functional and integrative medicine, Dr. Taz has become a national social media influencer, author, speaker, podcaster, television star, and go-to expert in women’s health. Her latest book “The Hormone Shift” offers patients the tools they need to navigate life’s hormone changes with ease. In today’s episode, we...2024-01-2337 min
The Lab ReportWhat We Don't Know About Hormones - Part 2Genova’s new Endo+ Profile is the first of its kind in hormonal health, offering the unique ability to test saliva, blood, and urine simultaneously. This flexibility lets providers create tailored hormonal profiles that reveal insights and connections between sex hormones, thyroid function, adrenal health, melatonin rhythms, and estrogen metabolism. While creating this product, we spent years scouring the research for the most up-to-date clinical information. Some of what we found, or more importantly didn’t find, calls into question what gets repeated in the echo chambers of functional medicine. Today is part 2 of our series where we c...2024-01-1624 min
The Lab ReportWhat We Don't Know About HormonesHormones are complicated! The body makes dozens of hormones that influence each other. Fine-tuning that full hormonal symphony can lead to significant symptom improvement and well-being. Genova’s testing can help and the new Endo+ Profile is a great place to start. With this latest product upgrade, we’ve spent almost 2 years scouring the literature for the most up-to-date clinical information to help guide clinicians. However, while we were knee-deep in research and literature, we found ourselves with conflicting messaging and realized the echo chamber in personalized medicine might need to be re-examined. In today’s episode, we begin...2024-01-0925 min
The Lab ReportHelping Men Ditch the Dad-Bod with Ali GilbertThe subject of men’s health is often not discussed. A lot of men don’t proactively seek help for health concerns nor even want to admit there’s a problem. Well, today we’re going to change that. Ali Gilbert is a nationally recognized coach, lecturer, personal trainer, and expert in men’s health. Her Silverback Coaching programs help men from all walks of life, from CEOs to professional athletes and regular dads get to optimal physical and mental health. Today we meet Ali Gilbert and hear about her passion to help men get jacked, look great nake...2024-01-0342 min
The Lab ReportA Holiday Hodgepodge [Rebroadcast]When it comes to holiday traditions, we think of decorating Christmas trees, baking cookies, the Elf on the Shelf, or lighting a menorah. But holiday traditions are far more unusual and diverse throughout the world. Some might really surprise you! On today’s episode, we touch on some unusual international holiday customs you’ve likely never heard while sprinkling in some clinical pearls. We also continue our podcast tradition of reading The Lab Report’s special rendition of ‘Twas the Night Before Christmas. Today on The Lab Report: 5:00 Kentucky Fried Christmas 7:00 The Christmas Pickle 8:55 Pooping lo...2023-12-1927 min
The Lab ReportNavy SEAL Wisdom & Leadership with William BranumWilliam Branum is a decorated Navy SEAL veteran with 26 years of active-duty service. Since leaving the military, William has dedicated his life to helping others through mentorship, coaching, speaking, and entrepreneurship. William’s expertise has been sought after by organizations ranging from small universities to Fortune 500 companies. He draws on his experiences to provide practical advice on how to cultivate a leadership style that inspires and motivates others, and how to develop the resilience needed to succeed in challenging environments. William founded the company ‘Naked Warrior Recovery’ to develop premium CBD products to support mental and physical recovery, through which...2023-12-0555 min
The Lab ReportAll Things Magnesium with Dr. Robert FredricksonMagnesium is a mineral that is crucially important to hundreds of biochemical reactions in our body. With gradual changes in soil, food processing, and the Standard American Diet, many of us just are not getting enough. So, what do we do? Dr. Robert Fredrickson has recently released a book all about this issue: Magnesium Answers: Unlocking the Secrets of Magnesium. As a functional medicine practitioner, he spent his career educating patients and doctors, but he also has a background as a product educator for major supplement companies. With that, Dr. Fredrickson is in a unique position to help us...2023-11-2842 min
The Lab ReportThe Thanksgiving Episode - Encore PresentationThanksgiving is a time to be mindful and reflect on our many blessings. During the holiday, many of us enjoy dinner with family and friends without stopping to consider the nutritional aspects of traditional dishes. Today, we discuss the important biochemical and nutritional benefits of Thanksgiving dinner items. We also talk about dealing with the stress of the holidays and the many reasons we are grateful. Today on The Lab Report: 3:30 Turkey and tryptophan – is it a thing? 5:15 Cranberry sauce apologetics 7:45 Potatoes! - and the microbiome 10:35 Green bean casserole, (fake) mushrooms, and onions 13:15 Hollandaise sauce? Gravy? St...2023-11-2122 min
The Lab ReportInflammation Signals - Patti & Michael Vamp on PAMPs, DAMPs, & LAMPsThe immune system works tirelessly to maintain health and well-being. This formidable defense mechanism is comprised of a vast array of cells, tissues, proteins, and molecules that work together to identify and neutralize foreign invaders. The inflammation that ensues can be recognized by redness, pain, swelling, and heat. In order for this process to take place, the body needs to be able to identify what is ‘friend or foe’. But how? There are certain molecular patterns that our immune system recognizes as part of this surveillance and recognition. Some patterns are associated with pathogens - “pathogen-associated molecular patterns” (PAMPs). Others a...2023-11-1423 min
The Lab ReportBrendan Vermeire- Leading the Mental Health RevolutionWhen it comes to changing the way the world views mental health, one voice remains consistent, science-based, empathetic, and passionate. That’s Brendan Vermeire. Brendan is dedicated to advancing the science of mental health dysfunction through his research, teaching, writing, and speaking. Here in functional and precision medicine, we are always looking for the root cause of any dysfunction. However, Brendan reminds us that mental health can have several root causes that need to be addressed and many of us are falling short when it comes to treating patients with mental illness. In today’s episode, we meet...2023-11-0742 min
The Lab ReportNonpathogenic Parasites? [Rebroadcast]The topic of intestinal parasites and their prevalence is hotly debated in functional medicine. Furthermore, the increasing trend of people performing a ‘parasite cleanse’ of the GI tract can be dangerous. Parasites are diagnosed in the stool using microscopy, direct exam, and PCR – but even then, not all parasites should be treated. Some can cause significant illness, yet others are not invasive, self-limiting, and considered nonpathogenic. In today's episode, we give a refresher course on gut parasites, discuss different ways to assess them, and introduce the topic of nonpathogenic parasites that don’t need to be treated. Tod...2023-10-3125 min
The Lab ReportThe Best Ways to Test the MicrobiomeWhen it comes to assessing the microbiome, technology continuously evolves. With that, our understanding of the microbiome deepens. There is a lot of confusion out there regarding technology. Companies use marketing spin to lead you to believe the newest is the best when in fact, every technology has its strengths and weaknesses. No one method can capture the entire dynamic of the microbiome. Here at Genova, we use many methods to give you the most complete look at overall gut health. Today we simplify the science behind laboratory assays used to study the microbiome – culture, qPCR, metagenomics, an...2023-10-2434 min
The Lab ReportDr. Michael Hilts on the Direct Primary Care ModelMany clinicians learn about functional medicine and get very excited to start but just can’t figure out how to fit it into their practice or make the big leap away from conventional, insurance-based practice models. Dr. Michael Hilts figured it out. Dr. Hilts found out about the “Direct Primary Care” model which allowed him to fulfill his dream of bringing the best healthcare possible to his patients. In addition, his innovative strategies with outside imaging centers, laboratories, and pharmacies bring down the cost to patients in an almost unbelievable way! Could this be the answer to fixing our curren...2023-10-1735 min
The Lab ReportProgesterone - The Mother of All Hormones?When it comes to sex hormones, progesterone is the unsung hero. It is actually the precursor to even making estrogen and testosterone. But progesterone is not just a precursor hormone. It is vital for maintaining pregnancy, helps with mood and sleep, works to help regulate the body’s water stores, and so much more. In today’s episode, we unpack all of the important functions of progesterone, break down its many fates of metabolism, and talk about ways to optimize your hormonal balance. Today on The Lab Report: 3:30 What is progesterone and where is it mad...2023-10-1031 min
The Lab ReportLiving Young For a Lifetime with Dr. Jeffrey GladdenHave you ever said to yourself “Hey, I’m doing pretty good for my age”? Well, today’s episode will change everything you thought you knew about aging. Dr. Jeffrey Gladden is not only a renowned expert in longevity medicine but also a cardiologist, author, international speaker, and host of The Gladden Longevity Podcast. His personalized approach, ground-breaking therapies, and team of experts help guide you on a journey toward optimal health, longevity, and performance. Dr. Gladden’s latest book “100 is the New 30 – How Playing the Symphony of Longevity Will Enable Us to Live Young for a Lifetime,” outlines a roadmap to bou...2023-10-0339 min
The Lab ReportHunger Hormones - Patti & Michael Talk Leptin and Adipose TissueMany of us think of adipose tissue as just a place to store excess fat to be used for energy. However, adipose tissue is very biologically active and secretes some important hormones and mediators called adipokines. These messengers help regulate glucose and lipid metabolism, control hunger, and affect insulin levels. That being said, ALL of our hormones work together like a symphony – cortisol, thyroid hormones, sex hormones, and don’t forget the adipokines. In today’s episode, we discuss important bioactive messengers created by our fat tissue (leptin and adiponectin), how they affect us systemically, and strategies to opt...2023-09-1927 min
The Lab ReportMicrobiome Diversity [Rebroadcast]The commensal bacteria in the gut microbiome are responsible for so many important functions. Their influence is far-reaching as it relates to overall health. Research shows us that the more diverse that community of bacteria is, the more beneficial it is to systemic health. But what does diversity mean and how do we measure it? There are many calculations used when it comes to diversity of the microbiome, and they can sometimes give differing information. It’s important to understand what’s being measured in order to clinically correlate the result. In today’s episode, we discuss the in...2023-09-1224 min
The Lab ReportTop 5 NutrEval QuestionsThe NutrEval Profile is Genova’s most comprehensive nutritional assessment providing a framework of core nutrients in the areas of antioxidants, B-vitamins, digestive supports, essential fatty acids, and minerals. This functional evaluation is aimed at assessing nutrient insufficiencies and biochemical individuality. In the Medical Affairs department, we are privileged to speak with clinicians every day to interpret test findings in clinical context, answer general questions about testing, and dive into the latest literature to expand our understanding too. On today’s episode, we address the top 5 most frequently asked questions about the NutrEval. Although we are focusing on the...2023-09-0523 min
The Lab ReportDr. Filomena Trindade - Cardiovascular Disease in WomenThere are very few key opinion leaders that hold extensive certifications in functional and integrative medicine who not only lecture, mentor, and teach but also continue to practice full-time and harness decades of clinical expertise like Dr. Filomena Trindade. An internationally sought-after speaker, and mentor to hundreds of clinicians, Dr. Trindade continually scours literature for the latest research on hormonal and metabolic health. Her latest focus has been cardiovascular disease. On today’s episode, we dive into the latest insights regarding cardiovascular disease in women with Dr. Filomena Trindade. We discuss the interplay between women’s hormones, insu...2023-08-2950 min
The Lab ReportFatty Acids & Inflammation [Rebroadcast]Inflammation is your body’s way of protecting itself from infection, injury, or other insults. Chemical signaling molecules called ‘eicosanoids’ are responsible for creating pain, heat, swelling, and redness. Eicosanoids are made from fatty acids, or dietary fats. We’ve all heard of fish oil and omega-3s being important when it comes to lowering inflammation. But why? In today’s episode, we break down the inflammatory cascade, explain how fatty acids are involved, and we answer the question ‘What in the world is an eicosanoid!?’ Today on The Lab Report: 3:20 What are eicosanoids? 6:05 Fatty acids an...2023-08-1521 min
The Lab ReportDr. Dwayne Jackson - Metabolism, Myths, & MotivationDr. Dwayne Jackson has spent decades in medicine and physiology. He lectured and taught at some of the finest universities in the world. In addition to academia, Dr. Jackson has been a staple in the fitness industry - both as an athlete and trainer. He is recognized internationally for his award-winning research which has shaped our understanding of chronic stress and its impact on immunity, inflammation, and mental health. In today’s episode, Dr. Dwayne Jackson combines his vast knowledge of physiology with his long career in the fitness industry to help us cut through some of th...2023-08-0854 min
The Lab ReportAmber Shaw - Consistency and Confidence for Middle-Aged WomenAmber Shaw is a Mind & Body Transformation Expert and the Founder of The Wellness Revolution. She works with women over the age of 40 to empower them to rediscover their confidence and create a sustainable lifestyle. Amber’s approach fosters consistency, accountability, and kindness. Women can be quite hard on themselves rather than show self-love. Shifting hormones, the demands of family and career, and a very confusing diet landscape can all be difficult to navigate. This is where Amber Shaw chose to build her career. On today’s episode, Amber Shaw talks about helping women heal their relationship with...2023-08-0142 min
The Lab ReportPatti & Michael Put the Chrome in Chromatography [Rebroadcast]Here at Genova, we are incredibly proud of the high standards set by our laboratory director and the brilliant minds that work in the lab to keep things running smoothly. As clinicians, and consumers, many of us don’t give the inner workings of the lab a second thought. We take for granted that samples are sent, results are generated, and we can clinically act on those findings. Most of our profiles rely on several different laboratory methodologies to put the whole story together. One of those methods is called Chromatography – and clinicians don’t fully understand what that actual...2023-05-3040 min
The Lab ReportPatti & Michael on Nutrient TestingWe know nutrition is important. But with all of the confusion around different diet camps out there, (Mediterranean, paleo, vegetarian, keto) many of us don’t know where to start. How do we know if we’re getting proper nutrition to keep us healthy? Are you keeping up with how your body uses nutrients due to exercise, growth, or wound healing? Is a nutrient insufficiency causing your depression or fatigue? Are you setting yourself up for cellular stresses and potentially chronic disease? Food diaries can help but sometimes they fall short. Here’s where testing can help. Today w...2023-03-0721 min
The Lab ReportA Year In Review: 2022Another calendar year in the books, and The Lab Report did not disappoint. Incredible interviews with some of the brightest minds in the health care industry, complex medical topics made easy, games, jingles, and loads of fun. As we approach the New Year, it’s a great time to listen back to some of the highlights (and lowlights) from the podcast throughout 2022. On today’s episode, Michael takes a walk down memory lane while Patti is away on vacation – though, despite the distance you can’t separate the dynamic duo. Today on The Lab Report: 2:15...2022-12-301h 17
The Lab ReportPatti & Michael Break Down Biofilms [Rebroadcast]Bacteria are everywhere in the environment. Although we understand there is a delicate balance of bacteria in our bodies which keep us healthy, many don’t grasp the complexity of how bacterial populations interact, adapt, and survive. They form structures called ‘biofilms’ which have become a hot topic in functional medicine as it relates to treating resistant or recurrent infections. In today’s episode, we dive into the topic of bacterial biofilms- when to suspect them and ways to treat them. Today on The Lab Report: 4:00 What are biofilms? 6:05 EPS, persister cells, and quorum sensing...2022-10-1121 min
The Lab ReportMilk? (Patti & Michael on the A1 vs A2 Debate)Many patients are not able to tolerate milk and dairy products due to GI symptoms such as bloating or diarrhea. In functional medicine, an elimination diet or food antibody testing can help uncover if the casein in cow’s milk might be at the root of these symptoms. Patients often turn to milk alternatives such as plant and nut ‘milk’ to avoid the difficulties with cow’s milk. However, research is showing that it may be a specific type of casein that is causing the problem in milk and there is a debate on the health risks of types of casei...2022-06-1423 min
The Lab ReportPatti & Michael "Air" it OutYour smartphone weather app likely includes insight into the “Air Quality Index”. But what does it mean and why should you care? We don’t often stop to take into consideration the quality of the air we breathe. Environmental toxins are everywhere – food, water, soil, and yes, air. Not only can toxins in the air directly affect your lungs, but there are also long-term systemic health effects that may be less obvious. In today’s episode, we talk about indoor and outdoor ‘air quality,' the connection to chronic disease, and ways to mitigate potential damage. Today on T...2022-04-0527 min
The Lab ReportPatti & Michael Cover the Electron Transport Chain (Rebroadcast)Cellular respiration is the process of converting our food into energy to fuel the body. It involves many biochemical reactions to create a molecule called adenosine triphosphate (ATP) - our main energy source. When it comes to ATP production, many of us think about the Krebs Cycle not realizing it is only part of the story. The Electron Transport Chain bears the brunt of the work to keep our cells alive and our bodies functioning optimally. Although biochemistry can seem challenging, in today’s episode we break it down into simplistic terms and explain why you should ca...2021-12-0721 min
The Lab ReportThe Thanksgiving Episode (Rebroadcast)Thanksgiving is a time to be mindful and reflect on our many blessings. During the holiday, many of us enjoy dinner with family and friends without stopping to consider the nutritional aspects of traditional dishes. Today, we discuss the important biochemical and nutritional benefits of Thanksgiving dinner items. We also talk about dealing with the stress of the holidays and the many reasons we are grateful. Today on The Lab Report: 3:30 Turkey and tryptophan – is it a thing? 5:15 Cranberry sauce apologetics 7:45 Potatoes! - and the microbiome 10:35 Green bean casserole, (fake) mushrooms, and onions 13:15 Hollandaise sauce? Gravy? St...2021-11-2522 min
The Lab ReportLipid Ratios - Patti & Michael Talk the New Cardio CheckMany clinicians and patients keep a close eye on cholesterol levels and standard lipid measurements as a way to stratify cardiovascular disease risk. What if there’s more to the story? Genova Diagnostics recently launched a brand-new profile called “Cardio Check.” This profile not only measures conventional lipid levels but also includes cardiometabolic biomarkers and lipid ratios which are being touted in the literature as even more clinically important than lipid levels alone. In today’s episode, we discuss a few of the lipid ratios included on the Cardio Check and explain why merely targeting LDL (aka the ‘bad...2021-09-2123 min
The Lab ReportPatti & Michael Discuss The Gut-Brain Axis (Rebroadcast)Did you know that there is a connection between the brain and the GI tract? This gut-brain axis communicates information in both directions. The commensal bacteria in our gut and their metabolites can directly affect our memory and mood, while our brain can alter bacterial patterns and GI function. Today we discuss some of the mechanisms by which this axis sends and receives those signals. We also talk about the importance of addressing both when optimizing health. Today on The Lab Report: 2:30 New Game Alert! Vegetablization of names 4:05 Question of the Day/Fireball: S...2021-09-0323 min
The Lab ReportPatti & Michael Talk Endothelial DysfunctionThe endothelium is a single layer of cells lining the inside of our blood vessels – and other internal organs. Not only is it responsible for signaling the contraction and dilation of vessels, but it controls clotting, inflammation, oxidative stress, and more! When this system breaks down, its effects are wide-reaching. Endothelial dysfunction is often the root cause of subsequent cardiovascular disease, strokes, and many chronic conditions. Because it can sometimes be reversible, understanding what causes it, how to treat it, and what you can do to prevent it becomes vital. In today’s episode, we discuss the phys...2021-08-2021 min
The Lab ReportA Podcast for the AGEsSummer is nearly here, and that means backyard barbecue season. Cooking certain foods with high heat causes something called the “Maillard Reaction” – which is a chemical reaction between fat, proteins, and sugars that gives browned and seared foods, like barbecued meats, their flavor. The result of this reaction is the formation of advanced glycation end products or AGEs. High amounts of AGEs have been implicated in many chronic health conditions. In today’s episode, we explain what AGEs are, tell you which foods naturally contain AGEs, and ways to mitigate their harmful effects. Today on...2021-06-0119 min
The Lab ReportPatti & Michael Break Down BiofilmsBacteria are everywhere in the environment. Although we understand there is a delicate balance of bacteria in our bodies which keep us healthy, many don’t grasp the complexity of how bacterial populations interact, adapt, and survive. They form structures called ‘biofilms’ which have become a hot topic in functional medicine as it relates to treating resistant or recurrent infections. In today’s episode, we dive into the topic of bacterial biofilms- when to suspect them and ways to treat them. Today on The Lab Report: 4:00 What are biofilms? 6:05 EPS, persister cells, and quorum sensing...2021-05-2521 min
The Lab ReportPatti & Michael Talk Pet TherapyMany of us have pets and consider them part of the family. They offer emotional support, companionship, and bonding. Did you know that they are very important for your health? Beyond pets, the medical field is now recognizing the healing qualities of many types of animals. Animal-assisted therapies are being incorporated into clinical treatment plans to improve health outcomes in many chronic conditions and diseases. Today we dive into the concept of animal-assisted therapy. We take a look into the literature as it relates to psychological outcomes, cardiovascular disease, and more. Today on The Lab R...2021-04-2321 min
The Lab ReportPatti & Michael On The Benefits of Bone BrothAnimal protein from meat is an important part of a healthy diet. But many of us overlook further using the animal bones to provide additional healing properties. Simmering animal bones over an extended amount of time helps extract minerals, collagen, and other important nutrients into a broth. Bone broth can then be used as stock for other soups or ingested itself to improve health. Listen in as we discuss the many health benefits of bone broth and why you should consider adding it to your diet – oh yeah, we also demonstrate how to make it – kind of. 2021-04-0622 min
The Lab ReportPatti & Michael Discuss Nature TherapyIt seems intuitive that being outside in nature is therapeutic and beneficial to our health. What many might find surprising is the amount of clinical evidence supporting nature therapy and the specific physiologic changes that result. ‘Grounding’ and ‘earthing’ are terms that are commonly used these days but even those words under-represent the fascinating biochemical and physiologic effects of nature. In today’s episode, we dive into the different facets of nature therapy, literature to support it, and how being outside can improve health– and hey, its Spring! Perfect timing! Today on The Lab Report: 2:30 Int...2021-03-2322 min
The Lab ReportPatti & Michael Deal With Oxidative Stress (Rebroadcast)What are free radicals and oxidative stress? How do free radicals impact the health and wellness of our patients? Why should clinicians analyze and measure a patient’s free radicals and oxidative stress levels? What can this information tell us about our patient’s overall health and their risk of developing a chronic disease? Today, we simplify the complex topic of free radicals and their connection to oxidative stress. We discuss the benefits and drawbacks of free radicals in your body and how antioxidants can help you decrease them while eliminating oxidative stress levels. We discuss what comm...2021-02-1932 min
The Lab ReportPatti & Michael Talk Wellness With Taylor DukesTaylor Dukes is functional medicine nurse practitioner with a burgeoning practice and growing online social media presence. Her expertise is vast - working with women in prenatal and postnatal care, helping professional athletes optimize performance, and improving the health of thousands of patients including CEO’s and celebrities. On today’s show, we discuss her journey from conventional to functional medicine and her unique approach to wellness. Today on The Lab Report: 3:20 Meet the fabulous Taylor Dukes 6:50 Taylor’s approach to fertility and postnatal care 10:05 Implementing functional medicine testing 11:25 Where to start with professional athlet...2021-02-1222 min
The Lab ReportPatti & Michael Cover the Electron Transport ChainCellular respiration is the process of converting our food into energy to fuel the body. It involves many biochemical reactions to create a molecule called adenosine triphosphate (ATP) - our main energy source. When it comes to ATP production, many of us think about the Krebs Cycle not realizing it is only part of the story. The Electron Transport Chain bears the brunt of the work to keep our cells alive and our bodies functioning optimally. Although biochemistry can seem challenging, in today’s episode we break it down into simplistic terms and explain why you should ca...2021-01-2621 min
The Lab ReportPatti & Michael Talk DetoxWe live in a toxic world. Every day we are exposed to an array of environmental toxins in our air, water, soil, and food. Luckily, our body is well-equipped to handle most of them. Additionally, there are things we can do to help optimize the body’s detoxification process. Not only should we try to avoid toxins whenever possible, but we can also support the process of detoxification by focusing on nutrition, the GI tract, our skin, and proper hydration. In today’s episode, we review steps in the body’s process of detoxification and speak to Dr. Ch...2021-01-1240 min
The Lab ReportPatti & Michael Talk ToxinsOur daily lives are filled with toxic exposures which can affect our health. Luckily, our bodies are well-quipped to handle and detoxify most of them. However, excessive exposures can lead to some subtle clinical presentations and eventually serious physical side effects. In today’s episode, we discuss the sources of three common metal exposures, their physiologic importance, and how to test for them. Today on The Lab Report: 3:05 Biotransformation -defining terms 7:00 Why do we care about heavy metal exposures? 9:05 Lead 13:30 Mercury 16:50 Arsenic 20:15 Genova testing options 24:20 Question of the Day: What form of mercury is bei...2021-01-0827 min
The Lab ReportThe Lab Report: A Year In ReviewAs the year 2020 comes to a close, Patti and Michael reflect back on the past year of The Lab Report podcast, which is approaching one year old. This new educational platform was created to spread the word about functional medicine and promote a focus on health and wellness. Throughout the year, we’ve covered many topics and interviewed some amazing guests. We laughed a lot and learned so much along the way. As we head into the New Year, many people make resolutions to improve their health. In today’s episode we reflect on past shows and high...2021-01-0127 min
The Lab ReportThe Thanksgiving EpisodeThanksgiving is a time to be mindful and reflect on our many blessings. During the holiday, many of us enjoy dinner with family and friends without stopping to consider the nutritional aspects of traditional dishes. Today, we discuss the important biochemical and nutritional benefits of Thanksgiving dinner items. We also talk about dealing with the stress of the holidays and the many reasons we are grateful. Today on The Lab Report: 3:30 Turkey and tryptophan – is it a thing? 5:15 Cranberry sauce apologetics 7:45 Potatoes! - and the microbiome 10:35 Green bean casserole, (fake) mushrooms, and onions 13:15 Hollandaise sau...2020-11-2522 min
The Lab ReportPatti & Michael on Vitamin B-12Vitamins are carbon-containing (organic) molecules that are essential for normal metabolism. However, they cannot be made in our body in sufficient amounts which makes dietary intake of vitamins important. There are thirteen different vitamins, categorized depending on whether they dissolve in water (water-soluble) or can be absorbed with dietary fat and stored in the body (fat-soluble). In today’s episode, we focus on Vitamin B-12, the largest and most complex water-soluble vitamin. Hear about why we need it, how we get it, and what happens when you’re deficient. Today on The Lab Repor...2020-11-2025 min
The Lab ReportThe Thyroid Episode with Patti & MichaelThe thyroid gland plays a major role in regulating our metabolism. It releases hormones that influence nearly every system in the body, in addition to other hormones. Because of its far-reaching effects, the symptoms of thyroid dysfunction are widely variable and often over-looked. In today’s episode we discuss how to identify thyroid abnormalities, how to measure it properly, and some functional medicine interventions to improve thyroid function. Today on The Lab Report: 2:45 What is the thyroid and what does it do? 4:20 Symptoms of thyroid dysfunction 8:08 Thyroid hormone production and its physiologic cascade 12:45 Factors tha...2020-10-2329 min
The Lab ReportThe Healing Power Of LaughterThere is the well-known phrase “laughter is the best medicine,” but is there any truth to that statement? In today’s show, Patti and Michael explore some of the research around laughter and its physiological, biochemical, and clinical effects. Also, if there is evidence to support laughter as a modality, does this mean we should be prescribing laughter as a treatment? What would this look like in clinical practice? Finally, we speak to some of the team members to demonstrate the power of laughter. Today on The Lab Report: 2:30 Laughter fun facts 3:30 The MCET model 5:10 Clinical impact...2020-10-1621 min
The Lab ReportPatti & Michael Model Behavior ChangeMost of what we do in functional medicine revolves around some type of behavioral change. Patients struggle with adopting these positive changes in diet, movement, and mindfulness. Instead of labelling patients as ‘noncompliant’, what if clinicians could meet patients where they are and help them through the process? The Transtheoretical Model was developed to help understand behavior and can be used in practice to promote compliance. In today’s episode, we discuss the stages of behavior change and offer useful tips on how to approach coaching and educating patients. Today on The Lab Report...2020-10-0920 min
The Lab ReportPatti & Michael Put Blastocystis On BlastBlastocystis is one of the most common GI parasites encountered in clinical practice. There’s been some debate as to whether it’s friend or foe. There’s even more debate on how to treat it and whether it even needs to be treated. Newer technology shows that there are many different subtypes of Blastocystis. These subtypes may hold the key to understanding the nuances in clinical presentation and the difficulty in eradicating it. Today we introduce Blastocystis and discuss how the subtypes may influence presentation and treatment. Today on The Lab Report: 3:0...2020-10-0225 min
The Lab ReportPatti & Michael Discuss The Gut-Brain AxisDid you know that there is a connection between the brain and the GI tract? This gut-brain axis communicates information in both directions. The commensal bacteria in our gut and their metabolites can directly affect our memory and mood, while our brain can alter bacterial patterns and GI function. Today we discuss some of the mechanisms by which this axis sends and receives those signals. We also talk about the importance of addressing both when optimizing health. Today on The Lab Report: 2:30 New Game Alert! Vegetablization of names 4:05 Question of the Day/Fi...2020-09-2223 min
The Lab ReportBreaking Down Protein with Patti & MichaelProteins are large molecules made up of smaller building blocks called amino acids. As a macronutrient, protein can be obtained in our diet from both plants and animals. Protein is metabolically critical and structurally necessary to keep us healthy. When protein is broken down into amino acids, each of them have their own function and importance as well. Are you getting enough protein in your diet? What happens in the body if you’re deficient? How do you get more? In today’s episode, we discuss all things protein. We also single out a few specific amino acid...2020-09-1137 min
The Lab ReportPatti & Michael Discuss GI ParasitesA parasite is an organism that lives in a host and takes its nourishment from that host. In the GI tract, their presence can manifest in many ways. The main classes of parasites include protozoa, roundworms, tapeworms, and flukes. Whenever Patti & Michael have questions about microbiology, they turn to Jim Kelton who has been part of the microbiology department at Genova for nearly 20 years. In this episode, we get Jim’s take on parasitosis and clarify the methodologies for detecting parasites. “We developed fire back in the Stone Ages for a reason, and one of them was to c...2020-08-1427 min
The Lab ReportPatti & Michael Weigh In on Weight LossManaging weight is more than calories in/calories out. There are many hidden factors that may be inhibiting weight loss such as hormonal influences, stress, toxic exposures, and maladaptive behaviors. One of the basic principles of functional medicine is that all patients are different and therefore, a personalized approach is needed. In this episode, we redefine some ideas around weight loss and discuss the many factors that need to be considered in order to develop a successful weight loss strategy. “The body system is innately designed to cure itself. To allow this to happen you ne...2020-08-0736 min
The Lab ReportThe Methylation Cycle: Deep CutsMethylation is a very important enzymatic reaction responsible for so many crucial metabolic processes. In our last episode, we introduced the topic of methylation and the basics of the biochemical reaction. However, there are many subtle nuances to consider when assessing whether a patient’s methylation cycle is out of balance. Today, we dive a bit deeper into the biochemistry and peel back the layers to show how some of the specific biomarkers and backup pathways contribute to imbalance. And, what does that mean clinically? It may help to review our prior episode or use Genova’s Methy...2020-08-0426 min
The Lab ReportPatti & Michael Discuss Genova's New Metabolomix+ ProfileThere are different types of tests for different types of conditions and many of them have cemented their status as a standard procedure. However, not all tests are created equal, and sometimes you need a deeper look into your blood chemistry to truly find what’s wrong with your body. One of these tests is a metabolomic test. What is a metabolomic test? What do they measure and what do they indicate? Today, we describe what a metabolomic test is and what you can learn from the results. We explain some of t...2020-06-1922 min
The Lab ReportPatti & Michael Talk SNPology 101Our genetic makeup is the very foundation of what we are. From conception to death, our genes play a major role in determining our physical, mental, and even emotional attributes. Genes also determine how strong or susceptible we are to many conditions and diseases. There are also genes that change over time, and one of these genetic variations is called single nucleotide polymorphisms or SNPs. What are SNPs and how do they affect a person’s health? Today, we discuss what SNPs are and their importance in genetic health. We describe some of the common SN...2020-06-1623 min
The Lab ReportPatti & Michael Discuss HPA Axis DysfunctionNo one likes to feel stressed, but stressors are everywhere. From work and your colleagues to the current problem with the pandemic and the news about it, it’s almost impossible to not be stressed right now. This is where the danger lies. Once stress becomes “normal,” it becomes a problem that goes beyond mental and affects us from a physiological viewpoint. What happens when you’re always stressed out? What tests should you look into if you feel stressed all the time? Are there any supplements you can take for stress? Today, we discuss HPA Axis...2020-05-2237 min
The Lab ReportWhat is Beta-Glucuronidase and Why Should You Care ?There is much to say about probiotics and postbiotics, especially their role in immunity, disease, and most importantly, gut health. There is a multitude of tests available to analyze your gut health. One of the many biomarkers we need to monitor is beta-glucuronidase. What is beta-glucuronidase? What does it do? What does it mean if you have too much or too little of this enzyme? Today, we discuss what postbiotics are and why beta-glucuronidase is a critical biomarker for gut health. We explain what beta-glucuronidase does, how the body makes it, and why you can have too...2020-05-1221 min
The Lab ReportPatti & Michael Speak to Brigid Titgemeier about Functional NutritionNutrition is one of the major pillars of our health. What we eat can translate to how good we feel, how fast we think, and how far we can go without rest. Because of this, many common illnesses can be attributed to nutrition gaps, and a simple nutrition plan can serve as a form of treatment. How do you know which foods can heal you? Are all the bad foods we see online really harmful to us? Brigid Titgemeier of BeingBrigid joins us to answer these questions. Brigid Tigmeier is a registered dietitian who emphasizes on using...2020-04-1739 min