ESBL - Podcast Details

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USF Health’s IDPodcastsGram Negative Bacterial ResistanceDr. Becca Bruning, Infectious Diseases Pharmacy Specialist at the Moffitt Cancer and Research Institute in Tampa, FL, takes a deep dive into the subject of resistance mechanisms for specific gram negative bacteria. Dr. Bruning begins her talk by discussing the primary resistance mechanisms, including porin channels, efflux pumps, and other target sites. Extended spectrum beta-lactamases (ESBLs) are next covered, including typical bacterial species, identification techniques, ESBL testing, and the use of Piperacillin-tazobactam and carbapenems. Next, Dr. Bruning mentions AmpC-type resistance, and identifies the “HECKYES” bacteria. Pharmacokinetic and phamacdynamic considerations are explored, and specific antimicrobial agents are discussed. Lastly, Dr. Brun...2025-01-0949 min

Infection Control MattersCould you have an ERCP-related outbreak? Sequencing to the rescue but you'll have to trash the scope!In this episode, Martin talks to Cansu Cimen, a researcher at University Hospitals Groningen in the Netherlands, about a recent paper that documents an outbreak and in particular the critical role of next-generation sequencing (NGS) in tracking and controlling the transmission of MDROs via contaminated duodenoscopes. Focusing on an outbreak linked to ESBL-producing Citrobacter freundii and Klebsiella pneumoniae after endoscopic retrograde cholangiopancreatography (ERCP), standard culture methods failed to detect contamination. After many negative cultures using established methods, destructive dismantling of the implicated scope revealed contamination on hard-to-clean components, highlighting NGS as an effective tool for identifying pathogen...2024-11-0821 min

infektiopodInfektiopod #86: Multiresistente gramnegative Erreger – Teil 1In dieser Folgen wird es "nerdig": Wir besprechen anhand der IDSA Guidance on the Treatment of Antimicrobial Resitant Gram-Negativ Infections die multiresistenten gramnegativen Erreger. In dieser Folge - Teil 1 dieses Themas- geht es um ESBL (extended-spectrum β-lactamases ), AmpC Betalaktamasen und CRE (Carbapenem-resistant Enterobacterales). Wir erklären die unterscheidlichen Resistenzmechanismen, diskutieren deren Folgen und Therapiemöglichkeiten. Links: IDSA Guidance on the Treatment of Antimicrobial Resistant Gram-Negativ Infections 2024-10-0137 min

infektiopodInfektiopod #86: Multiresistente gramnegative Erreger – Teil 1In dieser Folgen wird es „nerdig“: Wir besprechen anhand der IDSA Guidance on the Treatment of Antimicrobial Resitant Gram-Negativ Infections die multiresistenten gramnegativen Erreger. In dieser Folge – Teil 1 dieses Themas- geht es um ESBL (extended-spectrum β-lactamases ), AmpC Betalaktamasen und CRE (Carbapenem-resistant Enterobacterales). Wir erklären die unterscheidlichen Resistenzmechanismen, diskutieren deren Folgen und Therapiemöglichkeiten. … „Infektiopod #86: Multiresistente gramnegative Erreger – Teil 1“ weiterlesen 2024-10-0137 min

Independent Insights, a Health Mart PodcastNew IDSA guidelines to treat drug resistant gram-negative bacteriaDrug resistance to antibiotics continues to escalate. This week we do a deep dive into the Infectious Disease Society of America's (IDSA) brand new guidance on the treatment of antimicrobial resistant gram-negative infections. The GameChangerThe new IDSA guidelines provide critical, evidence-based recommendations for managing drug-resistant gram-negative infections. The guidance offers health care providers clear strategies to improve outcomes and reduce the emergence of resistance.HostJen Moulton, BSPharmPresident, CEimpactGuests Geoff Wall, PharmD, BCPS, FCCP, BCGPProfessor of Pharmacy Practice, D...2024-09-0238 min

CEimpact PodcastNew IDSA guidelines to treat drug resistant gram-negative bacteriaDrug resistance to antibiotics continues to escalate. This week we do a deep dive into the Infectious Disease Society of America's (IDSA) brand new guidance on the treatment of antimicrobial resistant gram-negative infections. The GameChangerThe new IDSA guidelines provide critical, evidence-based recommendations for managing drug-resistant gram-negative infections. The guidance offers health care providers clear strategies to improve outcomes and reduce the emergence of resistance.Guests Geoff Wall, PharmD, BCPS, FCCP, BCGPProfessor of Pharmacy Practice, Drake UniversityInternal Medicine/Critical Care, UnityPoint Health 2024-09-0238 min

This Week in MicrobiologyHow Pseudomonas Became A Global PathogenTWiM explores evolution and host adaptation of Pseudomonas infections of plants, and the impact of COVID-19 on ESBL-producing E. coli on urinary tract and blood infections. Hosts: Vincent Racaniello and Michael Schmidt. Become a patron of TWiM. Links for this episode Evolution and host adaptation of Pseudomonas (Science) Type III secretion system, infection by injection (Nat Comm) Demographic inference with skyline plots (Peer J) Skyline plots (Taming the Beast) Panaroo, a bacterial genome analysis pipeline (Wellcome Sanger Inst) Impact of COVID-19 on ESBL-producing E. coli infections (Antimicro Resist Inf Control) Take the...2024-08-1058 min $Let\'s Talk Micro$ Let's Talk Micro147: Research in Medical Laboratory Science: moose, bears, ESBL, and moreResearch in MLS? In this episode Grace Leu-Burke, director of the Medical Laboratory Sciences (MLS) program at the University of Alaska in Anchorage, returns to the podcast. She talks to Luis about the research program the MLS students are involved in. They culture scat from moose, bears, and geese, perform identification and susceptibility testing, and more. What kind of antimicrobial resistance is found in this sample population? Tune in to learn more about this research. Link to JAM meeting registration: https://www.labjam.org/event/cc75ef76-49db-4175-8440-d194382bcf05/websitePage:d132f4da-b01b-4...2024-06-211h 15

The food ProcessorsGuest 43-Πεξαρά Ανδρεάνα : Μικροβιακή αντοχή και Τρόφιμα Ζωικής Προέλευσης: H προσέγγιση της «Ενιαίας Υγείας»Μα γιατί δεν με πιάνει το αντιβιοτικό?? Κόποτε ήταν πολύ εύκολο. Έπαιρνα αντιβίωση και σε 30 λεπτά ήμουν οκ. Πόσες φορές έχουμε ακούσει αυτό τον διάλογο ? Η μικροβιακή αντοχή (AMR) αποτελεί αντικείμενο παγκόσμιας ανησυχίας για τη δημόσια υγεία. Εάν δεν ληφθούν μέτρα, η AMR εκτιμάται να έχει ακόμη πιο σοβαρές επιπτώσεις για την υγεία παγκοσμίως. Οι ανησυχίες επιδεινώνονται από την έλλειψη ανακάλυψης νέων αντιβιοτικών. Η AMR θεωρείται ότι προκαλείται κυρίως από γονίδια ανθεκτικότητας στα αντιβιοτικά (ARGs). Τα γονίδια αυτά μεταφέρονται μεταξύ των ανθρώπων, των ζώων και του περιβάλλοντος, καταδεικνύοντας τη σημασία της προσέγγισης της «Ενιαίας Υγείας», ότι δηλαδή η υγεία του ανθρώπου είναι στενά συνδεδεμένη και εξαρτημένη από την υγεία των ζώων και του περιβάλλοντος. Δεδομένου ότι η τροφική αλυσίδα συνδέει όλους τους οργανισμούς με και στο περιβάλλον, η σχέση μεταξύ των τροφίμων και της AMR αποτελεί ζήτημα μείζονος ενδιαφέροντος. Τα ανθεκτικά στα αντιβιοτικά βακτήρια (AMRB) ή/και τα ARGs μπορεί να μολύνουν τα τρόφιμα σε οποιοδήποτε στάδιο, από την παραγωγή έως την τελική διάθεση στον καταναλωτή. Τα ζώα που παράγουν τρόφιμα θεωρούνται σημαντικές δεξαμενές AMRB, συμπεριλαμβανομένων του ανθεκτικού στην μεθικιλλίνη Staphylococcus aureus (MRSA), ανθεκτικών στα αντιβιοτικά Campylobacter spp., Enterobacteriaceae που παράγουν εκτεταμένου φάσματος-β λακταμάσες (ESBL), αλλά και ARGs (για παράδειγμα aphA, sul1, sul2, mecA, ampC) που μεταφέρονται από την εκτροφή στο τραπέζι, υπογραμμίζοντας τη σημασία των τροφίμων ζωικής προέλευσης στο ζήτημα της AMR. Επίσης η μόλυνση που σχετίζεται με την κακή υγιεινή, φαίνεται να αποτελεί βασικό παράγοντα για την μετάδοση της AMR κατά την επεξεργασία και τη μεταφορά των τροφίμων. Η σημασία των τεχνολογιών συντήρησης και επεξεργασίας των τροφίμων, παραδοσιακών (π.χ. ζύμωση) ή καινοτόμων (π.χ. μη θερμικές τεχνολογίες), για την AMR στα τρόφιμα βρίσκεται υπό έρευνα. Απαιτούνται παγκόσμιες διεπιστημονικές και ενοποιημένες προσεγγίσεις που βασίζονται στις αρχές της «Ενιαίας Υγείας» για τον περιορισμό της διάδοσης της AMR και την ευαισθητοποίηση και την εκπαίδευση σχετικά με τη χρήση των αντιβιοτικών. Η AMR βρίσκεται στο επίκεντρο της στρατηγικής της Ευρωπαϊκής Ένωσης για την παγκόσμια υγεία, με τον σχεδιασμό και εφαρμογή προγραμμάτων ελέγχου για τη χρήση των αντιβιοτικών και για την πρόληψη της διάδοσης των ARGs κατά μήκος της τροφικής αλυσίδας. 2024-06-1832 min

consilium infectiorum - Der infektiologische Klinik-Podcast#07 Vorsicht ist besser als Nachsicht- die perioperative Antibiotikaprophylaxemit Prof. Christian Eckmann In der aktuellen Podcast-Folge beschäftigten sich Prof. Mathias Pletz und sein Gast, Prof. Christian Eckmann aus Hann. Münden, mit der perioperativen Antibiotikaprophylaxe. Relevante Publikationen: Amerikanische Leitlinie zur antimikrobiellen Prophylaxe bei Operationen Würzburger Studie: Cefuroxim/Metronidazol vs. Cefazolin/Metronidazol zur Prophylaxe bei kolorektalen Operationen Israelische Studie: Mehr ESBL-Wundinfektionen bei ESBL Besiedelten Studie: Ertapenem-Prophylaxe vor kolorektalen Eingriffen und ESBL Besiedlung besser als Cefuroxim/Metronidazol ESCMID-LL: Perioperative Antibiotikaprohylaxe bei MRGN Ökonomische Daten zu nosokomialen Wundinfektionen in Deutschland ESCMID-LL: Dekolonisation von MRGN-Trägern Cochrane-Analyse: Orale ABx und Spülung als Prävention vor kolorektalen Eingrif...2024-05-171h 11

Infectious Disease PuscastInfectious Disease PuscastOn episode #42 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/09 – 11/21/23. Host: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, RSS, email Become a patron of Puscast! Links for this episode Progress toward measles elimination (CDC) Slaying the troll of transplantation (TID) Association between the neutrophil-to-lymphocyte ratio and adverse outcomes in children aged 2023-11-2836 min

Hjelp, jeg er sykepleier!#57 Smittevern og infeksjonssykepleie med: Smittevernsnerdene, del 2: Q&AVelkommen tilbake til podkast med Elin og Marthe bak instagramkontoen og hjemmesiden Smittevernsnerdene! I denne episoden besvares spørsmål fra publikum og dere lyttere har virkelig sendt inn gode og relevante spørsmål, som alltid! For hvordan skal man egentlig forholde seg til jobb og kollegaer i helsevesenet hvis man selv er helsepersonell med ESBL? Hva er de vanligste feilene som helsepersonell gjør når det kommer til smittevern og hvilken type smitte er “verst”? Dette er episode 2 av 2 med Smittevernsnerdene. Vask henda og kos dere med nok en lærerik episode! Den del gjerne begge episodene v...2023-11-2135 min

PestpoddenAntibiotikaresistens del 1Synes du også resistens er vanskelig? Fatt mot og bli med oss i Pestpodden på en reise gjennom resistensen! I anledning Antibiotikauken 2023 har vi nemlig to spesialepisoder. I del èn får du en enkel intro til antimikrobiell resistens - mens i del to intervjuer vi en av verdens fremste eksperter og forskere på feltet; Adam Roberts. Gled deg!Referanser:1.Barlow M, Hall BG. Phylogenetic analysis shows that the OXA beta-lactamase genes have been on plasmids for millions of years. J Mol Evol. 2002;55(3):314-21.2.D'Costa VM, King CE, Kalan L, Morar M, Sung...2023-11-1814 min

Medical RewritesBridesmaidsOur medical rewrite today will be for Bridesmaids. We have two deep dives today, tattoo infections and foodborne diarrhea. Please note that this podcast contains both plot spoilers and descriptions of infectious diseases found in the movie Bridesmaids.Movie suggestion form: https://tinyurl.com/8pa8sveyReferences2012 investigation of tattoo infections in Rochester New York: https://pubmed.ncbi.nlm.nih.gov/22913660/ 2019 investigation of tattoo infections in Miami: https://pubmed.ncbi.nlm.nih.gov/30452604/ Systematic review of tattoo infection pathogens: https://pubmed.ncbi.nlm.nih.gov/27788747/2023-08-2547 min

FebrilePièce de (Gram-negative) Resistance, Part 2: CREWelcome to Part 2 of this pair of episodes on management of antimicrobial resistant Gram-negative infections!! Drs. Hawra Al-Lawati and Pranita Tamma walk through the alphabet soup of CRE with 2 mini-cases. Don’t miss the prior episode (Febrile #76) for more on AmpC and ESBL!You can find the most updated 2023 IDSA Guidance at this link: https://www.idsociety.org/practice-guideline/amr-guidanceEpisodes | Consult Notes | Subscribe | Twitter | Merch | febrilepodcast@gmail.com 2023-07-1033 min

FebrilePièce de (Gram-negative) Resistance, Part 1: AmpC, ESBLWelcome to Part 1 of this pair of episodes on management of antimicrobial resistant Gram-negative infections!! Drs. Hawra Al-Lawati and Pranita Tamma walk through the alphabet soup of AmpC and ESBL with 3 mini-casesYou can find the most updated 2023 IDSA Guidance at this link: https://www.idsociety.org/practice-guideline/amr-guidanceEpisodes | Consult Notes | Subscribe | Twitter | Merch | febrilepodcast@gmail.com 2023-06-2653 min

InfectoCast#55 - ampC e ESBL - Mecanismos de resistência antimicrobianaNo episódio da vez Klinger e Jordan vão discutir um tema muito pedido pelos nossos ouvintes: mecanismos de resistência. Nesse episódio em especial, falaremos de ampC e ESBL: o que é, marcadores no antibiograma e como tratar. Manda para o seu amigo que precisa aprender também! Vem com a gente.2023-04-0629 min

Mayo Clinic Pharmacy Grand RoundsIt’s in the Genes: Identification and Treatment of ESBL-ESarah A. Chase, PharmD identifies the most common ESBL-producing bacteria and common ESBL resistance genes, recognizes the use and limitations in using phenotypic and genotypic data to identify potential ESBL-E organisms and discusses clinical trial data and IDSA guidance to assist in the selection of appropriate antimicrobials for the treatment of ESBL-E infections . For more pharmacy content, follow Mayo Clinic Pharmacy Residency Programs @MayoPharmRes or the host, Garrett E. Schramm, Pharm.D., @garrett_schramm on Twitter! You can also connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or...2022-12-1431 min

Infectious Disease PuscastInfectious Disease PuscastOn episode #13 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 9/29/22 – 10/12/22. Hosts: Daniel Griffin and Sara Dong Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of Puscast! Links for this episode Efficacy and safety of switching to Dolutegravir/Lamivudine versus continuing Tenofovir Alafenamide (CID) Antibiotic combinations reduce Staphylococcus aureus clearance (Nature) Cholera Vaccine: Recommendations of the advisory committee on immunization practices (CDC) Detection of Treponema pallidum DNA during early syphilis stages (CID) Association between toxoplasmosis and bipolar disorder (Journal of Psychi...2022-10-1729 min

InfectEd: der Antibiotika-Podcast#15 A - Es brennt!Harnwegsinfektionen im Krankenhaus - Einteilung und Diagnostik mit PD Dr. Uta Kunter Diesmal geht es um Harnwegsinfektionen, vor allem um die mit komplizierenden Faktoren. Harnwegsinfektionen sind ein sehr weites Feld und da die Folge entsprechend lang geworden ist, haben wir diesmal 2 Teile daraus gemacht: A - Diagnostik und B - Therapie. WICHTIG! WICHTIG! WICHTIG! Wir sind ein universitäres Projekt und brauchen Dein Feedback! Bitte nimm Dir doch noch 5 Minuten Zeit für unseren [anonymen Fragebogen zur Folge]. **Diesmal gern auch erst, wenn Du Teil A und B gehört hast! **(https://survey-hygiene.charite.de/index.php?r=s...2022-09-201h 14

ID:IOTS - Infectious Disease Insight Of Two Specialists27. MurDeRing MDR Gram negs. Part 1: AmpC&ESBLJoin Jame as he talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.ECDC guidelines· https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x· https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0 Canadian guidelines· https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf IDSA- https://ww...2022-08-0842 min

ID:IOTS - Infectious Disease Insight Of Two Specialists24. Ambl(er)ing through beta lactamasesJoin Jame and Callum as they discussion all things beta lactamase including ESBL, AmpC and Carbapenemases. We talk through classification systems, patterns of resistance and some methods of detection. Some resources we found helpful:Summary of beta lactamase classification:https://microbeonline.com/betalactamase-classification/Summary of AmpC:https://www.idstewardship.com/heck-yes-get-amped-updates-ampc-harboring-bacteria/EUCAST detection of resistance:https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Resistance_mechanisms/EUCAST_detection_of_resistance_mechanisms_170711.pdfUK SMI on Carbapenemases:https://assets.publishing.service.gov.uk/government/uploads/sy...2022-06-241h 03