Shows
ESPGHAN PodcastTzivinikos C.: Magnet ingestionDr. Christos Tzivinikos graduated in 1999 from the Medical School of the Aristotle University of Thessaloniki, Greece. After several years serving as a medical officer aboard ships in the Greek navy, he began specialty training in paediatrics in the United Kingdom in 2005. Further training in gastroenterology followed between 2012 and 2015, culminating in a consultancy at Alder Hey Children’s Hospital in Liverpool, which he held until 2018. He then moved to Dubai, United Arab Emirates, to establish a paediatric gastroenterology, hepatology, and nutrition department at Al Jalila Children’s Specialty Hospital. Dr. Tzivinikos shares his expertise on foreign-body ingestion in children...
2026-02-2020 min
ESPGHAN PodcastUhlig H.: monogenic IBD: diagnosis, treatment, transitionIn 1990, Prof. Holm Uhlig entered the School of Medicine at the University of Leipzig – a city in Saxony with a long and turbulent history. The University, founded in 1409, had survived centuries of upheaval, including the Battle of Leipzig in 1813, when Napoleon’s forces were defeated and King Frederick Augustus I of Saxony was taken prisoner. Studying medicine in Leipzig during the 1990s meant navigating a period of significant transition following German reunification, yet Dr. Uhlig successfully completed his medical degree. Following his studies, he conducted research in paediatric immunology in Leipzig before spending three years at the Sir...
2026-02-1020 min
ESPGHAN PodcastJPGN Journal Club: March 2026: Biomarkers and Risk Stratification for Varices in Children with Portal HypertensionA round of applause, dear readers: We’ve made it into, good Heavens, 2026! Breasted the tape? Or limped across the finish line? No matter. To mis-quote Scripture, that is of course Stephen Sondheim: We’re still here. Among the “we,” and our lodestar, is Dr Jake Mann. He’s selected two articles for consideration: From Jezequel M et al., in work done at Lille, J Pediatr Gastroenterol Nutr brings us – Splenic stiffness does not predict esophageal varices in children with portal hypertension; and from a cluster of Parisian institutions, by Grimaud E et al. and published in Hepatology – Ser...
2026-02-0523 min
ESPGHAN PodcastStrozyk A.: Food LadderDr. Agata Stróżyk, a dietitian at the Medical University of Warsaw, shared her expertise on the “food ladder” in both theory and practice, providing insights for clinicians, patients, and families. She addresses questions such as:Could you explain what a food ladder is?What steps does a child typically go through during the food ladder process?What are the key benefits of milk and egg reintroduction for patients and families?What positive outcomes do you observe clinically?At the same time, what are the most common barriers and fa...
2026-01-2021 min
ESPGHAN PodcastMalmberg E.: Celiac diseaseYour ESPGHAN podcast team are collecting expertise from as many learnèd, skilled, and experienced paediatric gastroenterologists and hepatologists as possible! Oh, and from dietitians… they’re among the most important links in the chain between gastroenterologist and the universal goal – a healthy child and a happy family. Today’s note accompanies an encounter with Dr Elin Malmberg Hård af Segerstad, whose principal interests lie in the origins and management of the immune dysregulation manifest as coeliac disease. In a person with an inherited susceptibility to coeliac disease, what triggers the development of that disease? Ca...
2026-01-1021 min
ESPGHAN PodcastJPGN Journal Club January 2026: Coeliac Disease - Current Evidence on Therapy and DiagnosisHark! It’s midnight, children dear –Duck! Here comes another year! Well, readers, when this reaches you perhaps we shall all be in 2026, perhaps not; whichever, the New Year’s Eve couplet above may amuse you as you look backward, or forward, and… but who says that time has to be linear? Very twentieth-century idea, that – we’ve made progress since then. In any case, whenever this is, here we are. ESPGHAN Journal Club isn’t like the seasons, like the years, going around and around and enough to make your head spin. Journal Club instead has on...
2026-01-0122 min
ESPGHAN PodcastHoman M & Giamouris V.: three tricky cases along the new HP guidelineYoung ESPGHAN is on a roll! Today one of that group, a representative on the Education Committee, tries his hand at podcast interviewing: Dr Vangelis Giamouris was granted his medical degree at the University of Thessaly, trained in paediatrics in Athens at the Agia Sofia Children’s Hospital, and at present works at King’s College Hospital (London). He offers three clinical scenarios that involve Helicobacter pylori disease to Prof Dr Matjaž Homan for his perspective on diagnosis and treatment, in particular deployment of antibiotics. Prof Homan trained in Slovenia, taking his medical degree in Ljubljana, and has cond...
2025-12-2022 min
ESPGHAN PodcastBradley K.: ARFIDGreetings from Helsinki, where your ESPGHAN podcast team have taken the opportunity to buttonhole for interviews as many learnèd, skilled, and experienced paediatric gastroenterologists and hepatologists as possible! We haven’t forgotten the allied professions, mind you; this note accompanies for you an encounter recorded at the 2025 ESPGHAN Annual Meeting with Dr Kathryn Bradley, a clinical psychologist expert in Avoidant/Restrictive Food Intake Disorder (ARFID). Her work in “picky eating” is not her only credential in paediatric gastroenterology, hepatology, and nutrition: she is the mother of a child with total colonic aganglionosis, a lived experience o...
2025-12-1020 min
ESPGHAN PodcastJPGN Journal Club December 2025: Paediatric IBD: Vedolizumab Outcomes & PSC-IBD HistopathologyHappy holidays, everyone! The end of the year… twilight falls in mid-afternoon, there’s frost on the windscreen of a morning, and between mince pies and gingerbread, the supermarket aisles are an absolute menace. But there’s hope: ESPGHAN Journal Club is here to educate, to inform, and to keep you out of trouble – whilst you’re with us you’re not flexing those credit cards, are you? Here today is Dr Jake Mann with what he thinks we should know. Jake has chosen two variations on a theme: IBD, or inflammatory bowel disease. From Lancet Gastroenterol Hepatol, by A...
2025-12-0124 min
ESPGHAN PodcastNorris H.: Nutrition in the NeonateWelcome to the ESPGHAN podcast! Yes, it’s another of our series of interviews obtained at the sponsoring organisation’s annual meeting in Helsinki, today with Heather Norris, from Bristol. Ms. Norris trained as a dietitian – went slightly off-piste with two years of education in youth work and theology – and thereafter specialised first in paediatric nutrition and then, for the last fifteen years, in neonatal nutrition, working particularly in the last five of those years with the complicated patients born prematurely or having undergone surgical modification of the gut. She shares today her insights into approach...
2025-11-2020 min
ESPGHAN PodcastBirimberg L. and Massip E.: Gastrointestinal benefits from highly effective modulator therapy in CFOnce again it’s been an unfair contest here in the ESPGHAN podcast-recording studio, little me on one side, on the other Dr. Etna Masip Simó of Valencia and Dr. Liron Birimberg-Schwartz of Jerusalem – you listeners have ringside seats for the battle, which of course Dr. Birimberg-Schwartz and Dr. Masip won without so much as trying. They are experts in the nutritional dysregulation that results from cystic fibrosis, you see… Dr. Masip trained in Valencia and Catalonia, and now in Valencia heads the paediatric cystic-fibrosis unit at La Fe University and Polytechnic Hospital. Dr. Birimberg-Schwartz trained in Jerusal...
2025-11-1022 min
ESPGHAN PodcastJPGN Journal Club November 2025 - Pediatric Liver Transplantation and SarcopeniaIt’s ESPGHAN Journal Club, and—good heavens—it’s already November! Where did 2025 go? Lovely crisp sunny days, duvet-plus-blanket nights with very clingy cats, and foggy mornings with a fire in the woodstove to warm the kitchen and boil the kettle. After a nice cup of tea, let’s go shuffle-kick through the leaf piles with Dr. Jake Mann. Jake’s choices for today: From J Pediatr Gastroenterol Nutr, by Anouti A. et al., writing from several USA institutions — Pediatric liver transplant outcomes: A comparative analysis of steatotic donor grafts. To follow, by Chu C. et al., from southern...
2025-11-0123 min
ESPGHAN PodcastGuz A.: long-term management in pediatric chronic intestinal failureFrom Petah-Tikva, Israel – no map in your head? A tad east of Tel Aviv – at Schneider Children’s Medical Center, Dr. Anat Guz-Mark came to Helsinki for the ESPGHAN annual meeting, where this interview was recorded. Her particular interest and expertise lie in intestinal failure and its therapies, with surgical short-bowel syndrome, paediatric intestinal pseudo-obstruction, and a variety of congenital enteropathies among the problems that she, her patients, and her patients’ families face together. Listeners will learn her answers to five important questions:What are the common causes for chronic intestinal failure in children...
2025-10-2022 min
ESPGHAN PodcastGrammatikopoulos T. & Ackermann O.: Portal HypertensionJoint work, or collective work, holds out substantial promise for advancing our understanding of how pathophysiology evolves over time and how best to alter the course of disease. ESPGHAN fosters such collaboration – the podcast that this note accompanies is a good example. A recently established registry of children with portal hypertension and its complications illustrates this effort. In this episode, two physician-scientists who are among the registrars share their insights: Oanez Ackermann, of Le Kremlin–Bicêtre (Paris), and Tassos Grammatikopoulos, of King’s College Hospital (London). They address key questions:Why has a registry worthy of t...
2025-10-1019 min
ESPGHAN PodcastJPGN Journal Club October 2025: Advances in Pediatric Endoscopy and Ulcerative Colitis PrognosticsIt’s ESPGHAN Journal Club, in your thoughts and in your ears! Thanks for tuning in to learn what Dr. Jake Mann thinks are the raisins in the loaf for this month. Jake’s choices for today:Hoskins BJ et al. (Indianapolis, Indiana, USA), J Pediatr Gastroenterol Nutr – Pediatric endoscopic mucosal resection: A 10‐year single‐center experience.Kulecka M et al. (Cork and Galway, Ireland; Málaga, Spain; London; Utrecht), Nat Commun – Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.Hoskins et al.In what USAnians call...
2025-10-0124 min
ESPGHAN PodcastHadzic N.: Alpha 1 antitrypsin deficiencyProf. Dr. Nedim Hadžić – Dino attended the ESPGHAN annual meeting in Helsinki. Of course, your enterprising podcast team, lurking there to glean the thoughts and insights of the best and the brightest, snapped him up for an interview! His training and early professional work were in Sarajevo, Bosnia-Herzegovina, but when he obtained a research fellowship in London, his supervisors soon recognised that he was too good to be allowed to return home.(For those who follow Croatian football: the centre-forward for Team Orijent in Sušak / Rijeka is a different Nedim Hadžić.) Dino is now a...
2025-09-2024 minESPGHAN PodcastGriffiths A.: Initial Workup for PIBD Diagnosis and ClassificationInflammatory bowel disease: Important to assess, to treat, and to follow correctly, as Dr Anne-Marie Griffiths of Toronto confirmed in an interview recorded in Helsinki at the ESPGHAN annual meeting. She poses for us three questions:What are some of the consequences for the patient when caregivers mislabel the type of inflammatory bowel disease?What purpose is served by thorough diagnostic evaluation at presentation, with upper endoscopy, ileocolonoscopy, and small-bowel imaging?What are the goals to be achieved by using the Paris classification or any of its future modifications?This discussion a...
2025-09-1021 min
ESPGHAN PodcastJPGN Journal Club September 2025: Innovations in Genetic Diagnosis and Therapy for Pediatric Liver DiseaseWelcome back to ESPGHAN Journal Club! Give us your full attention, please – even if that means pulling into a lay-by or, even more demanding, setting down your drink. The thoughts and insights of Dr. Jake Mann are deffo worth the trouble. Jake’s choices for today:From J Pediatr Gastroenterol Nutr, by Tai CS et al., with authors from Taiwan, Thailand, and Korea: “A prediction model for genetic cholestatic disease in infancy using the machine learning approach.”From JCI Insight, by Arnson B et al., with authors from the United States and the Unite...
2025-09-0121 min
ESPGHAN PodcastGottrand F.: Long-Term Follow-Up of Esophageal AtresiaWelcome to the world of oesophageal atresia and its treatment, where Prof Gottrand is eminent. (A quick hat-tip: His devotion to patient care was distinguished by the Premier prix mondial de l’atrésie de l’oesophage, awarded in June, 2019, at the World Congress on Oesophageal Atresia.) Surgical repair of oesophageal malformations yields palliation rather than cure, with a bewildering mix of dysmotility, dysphagia, malnutrition, reflux, inflammation, malignancy, and pulmonary and otolaryngologic disease all as sequelae; how are these patients, whether with a remodelled native oesophagus or a substituted organ, to be assessed and followed? Monstrously complicated! And improvement in su...
2025-08-2023 min
ESPGHAN PodcastStaiano A.: ESPGHAN 100st Podcast EpisodeLa professoressa Annamaria Staiano è una figlia di Napoli, is a daughter of Naples, and to the city of her birth, medical education, and present professorial chair in paediatrics at the Università degli Studi di Napoli Federico II she has ever been loyal – aside from several years in St. Louis, Missouri, where she undertook subspecialty training in paediatric gastroenterology. She today is the guest of ESPGHAN at the hundredth podcast that your society has organised and sponsored. Think of it – one hundred podcasts! And that today she joins us is doubly a distinction, because her presidency of ESPGHAN was re...
2025-08-1024 min
ESPGHAN PodcastJPGN Journal Club August 2025: Portal Hypertension Management and Genetic Insights in CHAPLE DiseaseSummer! So hot... and everywhere is parched. The hosepipes are trickling in the twilight, both at dawn and at dusk – but is it true that watering one’s garden in the heat of the day injures the plants? Wherever you are, dear reader and listener, let’s hope it’s somewhere shady, and that on the table next to where you’ve chosen to lounge and listen is a tall glass of something with ice cubes and gin. Lots of gin. A tip of the hat to you who, under such adverse circumstances, have chosen to log in...
2025-08-0123 min
ESPGHAN PodcastScarallo L.: Putting intestinal ultrasound into practiceToday’s guest is Dr Luca Scarallo, one of the rising stars in the constellation of experts in inflammatory bowel disease. Dr Scarallo – I’m tempted to call him simply “Luca,” as he was born in 1993, which makes him impossibly young – comes from Benevento, lying east and south of Naples. That city, his birthplace, has a history as impossibly long as Luca is impossibly young. It flourished under the Roman Republic and Empire, was the southern capital of the German Longbeards, the Longobardi, who ruled much of Italy fifteen hundred years ago, and belonged to the papacy for almost a millennium...
2025-07-2021 min
ESPGHAN PodcastWine E.: New IBD Drugs in the Pipeline and How to Place ThemDr Eytan Wine was graduated from the School of Medicine at Tel Aviv University in 1998, with training in paediatrics at Wolfson Medical Center in Holon, Israel, followed by specialty training in gastroenterology, hepatology, and nutrition at the Hospital for Sick Children in Toronto, where he also earned a PhD degree for studies in bacterially induced intestinal inflammation. His first position as an attending physician began in 2009 at the Stollery Children’s Hospital in Edmonton, Alberta, where in 2021 he was appointed to a professorship of paediatrics at the University of Alberta – which he has just left to work again in Toronto at...
2025-07-1022 min
ESPGHAN PodcastAssa A. & Giamouris V.: three tricky cases along the new UC guidelineToday’s podcast is a change of pace.It showcases not only Prof Dr Amit Assa, offering his expertise in approaches to treatment of paediatric ulcerative colitis, but also Dr Vangelis Giamouris, a member of Young ESPGHAN who sits on the Education Committee. Dr Giamouris has put his head over the parapet: not your usual interviewer, but instead Vangelis will shoot questions at Prof Assa; Prof Assa will shoot answers back; and the listeners can enjoy the firefight. Vangelis, may the odds be ever in your favour! Dr Giamouris was granted his medical degree...
2025-06-2027 min
ESPGHAN PodcastOlen O.: Cancer Risk in PIBDA short hop from Stockholm to Helsinki, site of the 2025 ESPGHAN annual meeting, where this interview with Prof Ola Olén was recorded – in Finland, or East Sweden, as it was known until 1809, when the Treaty of Fredrikshamn / Hamina ceded both Finland and parts of both North and West Bothnia to Russia… Only in 1917 was the Grand Duchy of Finland pried away from the fragmenting Russian empire, and, mind you, the Russians, wearing their Soviet hat, stole Karelia back in 1940. Thinking of the state of the world today, we forget history at our peril; it’s never been easy to be a...
2025-06-1022 min
ESPGHAN PodcastJPGN Journal Club June 2025: Pediatric Bowel Wall Sonography and Long-Term Outcomes in MASLDGreetings from Helsinki, capital of yet another nation in which you have to watch your sushi! Boreal circumpolar dining for pescatarians… ring up another aetiology of Vitamin B12 deficiency, and check your erythrocytes’ mean corpuscular volume when you get home. At JPGN Journal Club, with Dr. Jake Mann, reaching you today from ESPGHAN’s annual meeting, we uniformly are alert against diphyllobothriasis, Scourge of the North. Herring is on the menu this week—wish us luck. Jake’s choices for today: From J Pediatr Gastroenterol Nutr, by Kellar et al., writing from a number of N...
2025-06-0118 min
ESPGHAN PodcastCanani B.: Ultraprocessed Food and Chronic GI DiseaseGreetings from Helsinki, where your ESPGHAN podcast team has taken the opportunity to buttonhole as many learned, skilled, and experienced paediatric gastroenterologists and hepatologists as possible for interviews! This note accompanies a conversation recorded there with Dr. Roberto Canani, an expert in paediatric food allergy. In this podcast, however, he steps away from what might be considered the principal theme of his expertise—namely, immunologic dysregulation at the enteric mucosa and beyond. Instead, he addresses three key questions:What are ultraprocessed foods?What evidence indicates that such foods facilitate the occurrence of...
2025-05-2023 min
ESPGHAN PodcastAnnual Meeting 2025 - Highlights from Helsinki with Elena CernatHot off the press – fresh from Helsinki – your ESPGHAN podcast team has interviewed Dr. Elena Cernat, a paediatric gastroenterologist originally from Romania, via Spain, and now working in Leeds. Dr. Cernat has handpicked six interesting abstracts from this year’s ESPGHAN annual meeting to discuss with us (she found many more, of course, but podcast time constraints – you’ll understand). She explains why she chose these particular abstracts… though it’s entirely possible your assessments may differ. Judge for yourselves! Abstracts (in order of discussion): 1. A cfCHIP-SEQ Liquid Biopsy for the...
2025-05-1624 min
ESPGHAN PodcastMeyer R.: gastrointestinal manifestations of food allergyDr Rosan Meyer, reared and educated in South Africa and for some years active in London as a paediatric dietitian, is the guest of ESPGHAN today. Her particular interest lies in the Protean gastrointestinal manifestations of food allergy and how to intervene to reduce or to eliminate them. Today she asks us to consider : -- Are feeding difficulties adequately recognised and treated in children with food allergy ? -- What is the context of the immune-supportive diet in addressing food allergy ? -- What advances have been made around food allergy and tole...
2025-05-1023 min
ESPGHAN PodcastJPGN Journal Club May 2025: Noncontrast Ultrasound in Pediatric IBD and Proteotoxicity in Alpha-1-Antitrypsin DeficiencyHello! The JPGN Journal Club, led by Dr. Jake Mann, is back — in your speakers, your earbuds, or maybe even over the airport tannoy… well, probably not the last one. Anyway, it's good to be back in touch. Please visit https://www.espghan.org/knowledge-center to explore current offerings, and don't forget ESPGHAN’s annual meeting, taking place May 14–17 in Helsinki.This session’s discussion papers:1.From Journal of Pediatric Gastroenterology and Nutrition (JPGN):Ritchie et al. (Aberdeen, UK, and Christchurch, NZ) –"Role of Noncontrast-Enhanced Abdominal Ultrasound in the Diagnostic Assessment of Pediatric Inflammatory Bowel Disease"A...
2025-05-0123 min
ESPGHAN PodcastHartleif S.: the biology of the transplanted liverDr. Steffen Hartleif was reared and educated in Bremen, one of the city-states in the Hanseatic League, famous for maritime trade; the son of a town and a culture that turned their backs on the land and opened their arms and hearts to the sea. Rejecting this proud heritage, he fled to southwestern Germany for medical education—almost as far from saltwater as a German can go—and has stayed there, working in the hospitals and clinics of Tübingen and that city’s medical university. His scientific contributions have been related to pediatric hepatology, especially to the biology of the t...
2025-04-2028 min
ESPGHAN PodcastDragutinović N.: paediatric hepatogastroenterologist in SerbiaWe are talking to Dr. Nataša Dragutinović, until recently of Belgrade’s University Children’s Hospital, about the difficulties — but, yes, also the joys — of training and working as a paediatric hepatogastroenterologist in Serbia, a nation shunned by the European Union since the Yugoslav Wars of the early 1990s. Resources are scant; health-care systems are underdeveloped; opportunities to travel abroad, to learn from and to train with providers of highly specialised care, are few. Nonetheless, during slightly more than a decade in her position the division to which she belonged doubled in size, from three to six plus a junior t...
2025-04-1034 min
ESPGHAN PodcastJPGN Journal Club April 2025: Probiotic Therapy in Pediatric Gastroenteritis and Early-Life Sugar ExposureSpring! The snowdrops are in their glory, the crocuses are a gaudy carpet, at least as this note is being compiled. Little darling, it’s been a long, cold, lonely winter, but here comes – no, not the Sun, instead, JPGN Journal Club, led by Dr Jake Mann. Please visit https://www.espghan.org/knowledge-center to examine the offerings, and don’t forget the Helsinki annual meeting, May 14-17, of ESPGHAN. Your podcast team will be there. Stop by, please, with your thanks, congratulations, suggestions, and love-offerings centred on chocolate; meet us in perso...
2025-04-0122 min
ESPGHAN PodcastGutierrez C.: eosinophilic oesophagitis (EOE)Today in the ESPGHAN podcast series we hear from Dr Carolina Gutiérrez Junquera of the Universidad Autónoma de Madrid on eosinophilic oesophagitis (EOE). Dr Gutiérrez Junquera passed in her training through the Complutense University of Madrid and its affiliated hospitals. After a fellowship in the San Francisco bay area, she went home to Spain to develop her interest in various aspects of EOE. She has become prominent as an organiser and evaluator of multi-institutional studies of this disorder. At present she is investigating proton-pump inhibitor (PPI) use in EOE, with focus on several questions: What is the rôle of P...
2025-03-2022 min
ESPGHAN PodcastSigall-Boneh R.: Active Crohn’s DiseaseWe hear today in our ESPGHAN podcast from Dr Rotem Sigall-Boneh of Israel’s Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Centre, Petach-Tikva, and the Faculty of Medicine, Tel Aviv University, Tel Aviv – sorry, the “Dr” is a few months away ; she’s earning a PhD (University of Amsterdam), and it’s in the bag, I expect – who has spent the last decade approaching the question of how exclusionary diets exert their beneficial effect in patients with inflammatory bowel disease (IBD), particularly Crohn disease. She asks us to consider : What is the rôle of diet in IBD treatment...
2025-03-1017 min
ESPGHAN PodcastJPGN Journal Club March 2025: Adolescent ALT Trends and Microbiome-Lipid Links to Malnutrition CognitionAre we all recovered from January, of all months the most Monday-ish? Experience might teach us how to cope with, dear Lord, the first of three more months of winter. But no. Instead, the older one becomes, the more burdensome January is. Well, take heart: In the wonderland of JPGN Journal Club, led by Dr. Jake Mann, as the accompanying podcast is recorded, we’re deep into February. Listeners, keep on keeping on! Spring WILL arrive – just not soon enough. Despite this horrid winter, ESPGHAN continues to work tirelessly for you. Visit https://www.espghan.org/k...
2025-03-0125 min
ESPGHAN PodcastLedder O.: Dilatation of the gastrointestinal tract in children- tips and tricksThis gem on the ESPGHAN string of pearls interviews Dr Oren Ledder, who is at once an Ozzie and an Izzie – an Australian who migrated to Israel, where he now directs the paediatric endoscopy service at Shaare Zedek Medical Center in Jerusalem. He today speaks on small-bowel stricture in inflammatory bowel disease, a focussed chat dealing with three questions in particular : 1. Which patients should be considered for endoscopic balloon dilatation of a Crohn's-disease stricture ? 2. Who should perform the procedure ? 3. Can dilatation of a stricture change the dynamics of regional inflammation ? The last consideration is...
2025-02-2021 min
ESPGHAN PodcastKelly D.: Long term liver transplant outcomesProf Dr Deirdre Kelly is today’s ESPGHAN podcast series guest, speaking on the long-term care of paediatric allograft-liver patients and the findings gleaned from protocol-biopsy studies. These have uncovered inflammation and fibrosis that are not clinically apparent ; although shifts in immunosuppressive regimen can ablate inflammation, fibrosis persists. (These findings come from patients whose biopsy procedures were not prompted by intercurrent disease. Thus long-term changes that led to clinically manifest biliary-tract injury, for example, were invisible a priori.) Recent problems include reluctance of adult hepatologists to conduct protocol biopsies in “ex-paediatric” patients – the adults whom they usually follow after liver transplantati...
2025-02-1022 min
ESPGHAN PodcastJPGN Journal Club February 2025: Serum Bile Acids in Biliary Atresia and ITGAV Variants in Immune DysregulationAt the watershed between 2024 and 2025, some readers will have remembered this couplet: “Hark! It’s midnight, children dear. / Duck – here comes another year!” In paraphrase, then, duck – here comes another instalment of JPGN Journal Club, led by Dr. Jake Mann! Before we move along to the articles to which Jake wants us to pay attention, have a glance at what ESPGHAN is doing for you at https://www.espghan.org/knowledge-center:2025.I.30: Monothematic Conference on Steatotic Liver Disease in Children.III.05: GI Immunology Master Class: From Pathogenesis to Clinical Management of EGID, Coeliac Disease, and IBD.IV...
2025-02-0124 min
ESPGHAN PodcastBontems P.: Capsule endoscopy in childrenAn old friend today – scratch that, a familiar friend – familiar to those who have followed these podcasts since their inception : Welcome to the studio from Brussels, Dr Patrick Bontems, head of “interventional paediatrics” at Hôpital Universitaire des Enfants Reine Fabiola ! This is his second appearance as an ESPGHAN guest, and we’re delighted to have him back to speak on aspects of percutaneous gastrostomy or duodenojejunostomy selection, placement, and management. He asks us to consider : When is gastrostomy or duodenojejunostomy indicated ? What can make such a procedure better accepted by referring doctors and by families ? Who should place these devices, the endoscop...
2025-01-2018 min
ESPGHAN PodcastHyer W.: the management of polyposis syndromes in paediatric patientsThree for two today ; one interviewer and two guests, Dr Warren Hyer and Ms Fiona Cargill-Marin in this ESPGHAN podcast, with its theme the management of polyposis syndromes in paediatric patients : Not so much the from-what-age and the what-to-look-for as the origin of the guidelines first put forward by ESPGHAN going on five years ago and spearheaded by Dr Hyer, who is among the leaders of a well-coördinated effort to systematise relevant care, bringing it away from adult endoscopy services and into a paediatric model – family care rather than simply patient care, modulation through adolescence into adulthood, and the l...
2025-01-1019 min
ESPGHAN PodcastJPGN Journal Club January 2025: Paediatric Crohn’s Disease Management and Failure-to-Rescue Insights in Liver TransplantationHappy holidays, everyone! Here’s JPGN Journal Club, led by Dr Jake Mann. Don’t forget ESPGHAN’s other educational offerings: https://www.espghan.org/knowledge-center – on 2025.I.15 the GI Winter School, on I.30 the Monothematic Conference on Steatotic Liver Disease in Children, and on III.05 the GI Immunology Master Class: From pathogenesis to clinical management of EGID, coeliac disease, and IBD. Jake’s choices for discussion today: From J Pediatr Gastroenterol Nutr, by Fioretti et al., writing from Edinburgh, “A decade of real‐world clinical experience with 8‐week azithromycin–metronidazole combined therapy in paediatric Crohn's disease”, and from Pediatr Transpl, ...
2025-01-0122 min
ESPGHAN PodcastMoltu S.: Nutrition for the critically ill neonateThe ESPGHAN podcast series today hopes to make you familiar with some of the work of Dr Sissel Moltu, a polyglot and polymath – she’s of Norwegian and USAnian heritage, was reared in Norway, took her medical degree in Freiburg, worked in England – who combined neonatology with gastroenterology when in Oslo University Hospital frustration at parenteral-alimentation – associated liver disease in short-bowel syndrome led her to make a career of investigating how best to feed the critically ill infant whilst sparing from injury the many growing systems, especially those of neurodevelopment (fatty-acid supplementation!). She poses these questions for us: How does criti...
2024-12-2020 min
ESPGHAN PodcastKamath B.: Alagille - A multifaceted conditionProf Dr Binita Kamath of first the United Kingdom (London’s King’s College Hospital), then the United States (Children’s Hospital of Philadelphia), then Toronto’s Hospital for Sick Children – and now, wait for it, the Children’s Hospital of Philadelphia again ! – speaks with us today in the ESPGHAN podcast series. She has seen diagnosis of Alagille syndrome (AGS) move from clinicomorphologic assessment into two-pronged genetic sorting (first JAG1, then NOTCH2) and its treatment move from surgery (liver transplantation, biliary diversion) to pharmacology, with drug-based faecal wasting of bile salts via administration of the intestinal bile-salt uptake inhibitor maralixibat – those...
2024-12-1021 min
ESPGHAN PodcastJPGN Journal Club December 2024: Human Milk in Biliary Atresia and Type III Interferon–Induced Pyroptosis in Gut EpitheliumDecember’s almost here, can you believe it ? Here’s JPGN Journal Club, led by Dr Jake Mann ! Don’t forget ESPGHAN’s other educational offerings : https://www.espghan.org/knowledge-center – on XII.27 the MOOC Enteral Nutrition in Preterm Infants conference, on 2025.I.01 the Young ESPGHAN Mentorship Programme, on I.15 the GI Winter School, and on I.30 the Monothematic Conference on Steatotic Liver Disease in Children. Jake’s choices for discussion today : From J Pediatr Gastroenterol Nutr, by Tessler et al., “The association of human milk intake and outcomes in biliary atresia”, and from Cell, by Jena et al., “Type III inter...
2024-12-0122 min
ESPGHAN PodcastCampoy C.: Childhood Obesity Prevention: Impact of nutrition during pregnancyThe ESPGHAN podcast series today addresses three points that have defined the recent career of Dr Cristina Campoy Folgoso, professor and chair of paediatrics at the Medical University of Granada, Spain. These ar : How maternal nutritional status can determine the offspring's growth and body composition during childhood ; which interventions during pregnancy may effectively prevent childhood obesity ; and which nutrients are most associated with the risk of childhood obesity. Prof Campoy touches on timing of nutritional events during pregnancy, with the early observation that mothers starved in the last trimester have small babies excessively avid for nutriment, babies who over-produce adipoc...
2024-11-2022 min
ESPGHAN PodcastDinning A.: Short Bowel SyndromeToday’s ESPGHAN podcast series guest, Mrs Alison Dinning, is an academic dietitian at the Children’s Hospital of Bristol in the west of England. Her interests centre on the care of children with short-bowel syndrome (SBS), with particular pleasure taken in successful shifts from parenteral to enteral alimentation – hard work, but if the family can be brought on board, then with use of breast milk, attention to what portions of the bowel are lacking, the use of blended (higher-density than simple liquid) feeds, and oral contact with food these children can be moved forward into enteral autonomy. This in hospita...
2024-11-1023 min
ESPGHAN PodcastJPGN Journal Club November 2024: Rapid Infliximab Monitoring and Lipid Profiling for Pediatric Obesity RiskNovember: Knocking on the door, or already inside and making itself at home ? Whatever. It’s JPGN Journal Club, led by Dr Jake Mann! Don’t forget ESPGHAN’s other educational offerings: https://www.espghan.org/knowledge-center – in particular on XI.11 the Winter School on Basic Science and Translational Research; on XI.15 a Masterclass on Transition from Paediatric to Adult Healthcare in Patients with GI or Liver Disease; and on XI.21 the 9th IBD Masterclass. Jake’s choices for discussion today: From J Pediatr Gastroenterol Nutr, by Bouhuys et al., “Lateral flow test versus enzyme-linked immunosorbent assay to measure infliximab tr...
2024-11-0121 min
ESPGHAN PodcastDeLaffolie J.: Artificial IntelligenceToday’s ESPGHAN podcast interviews Dr Jan de Laffolie, at present in Giessen (Germany), who has a strong interest in both inflammatory bowel disease and in “artificial intelligence”, or AI – that is, the sifting of data for correlations, not only those that are apparent to humans unassisted, call it to the naked eye / the naked mind, but also those that elude us mortals when we are on our own. Working within a tripartite framework of : 1) What is artificial intelligence and how can it be applied to paediatric gastroenterology, hepatology, and nutrition (PGHN) ? 2) What are disadvantages and risks as...
2024-10-2024 min
ESPGHAN PodcastDunitz-Scheer M.: Return to meal. Successful weaning from tube-feedingTurmoil after Hitler’s war brought together the parents of today’s guest, Dr Marguerite Dunitz-Scheer ; she was born in the United States, reared in Switzerland, and with a marriage became Austrian. She might have become a musician by profession – that was in her family’s blood, and she attended a conservatory as a teenager – but instead, true to the principle of everything, everywhere, and all at once that has informed so many of her life’s trajectories, she trained in medicine. There, as a young mother herself, she was appalled to see how cruelly abused in the interests of “weight gain”...
2024-10-1023 min
ESPGHAN PodcastJPGN Journal Club October 2024: Home Parenteral Nutrition in Neurologically Impaired Children and TNFRSF12A as a Therapeutic Target in Biliary AtresiaOctober JPGN Journal Club, led by Dr Jake Mann ! As always, keep in mind ESPGHAN’s other educational offerings : https://www.espghan.org/knowledge-center – in particular on X.25 a Monothematic Conference on Paediatric Gastric Disease ; on XI.11 the Winter School on Basic Science and Translational Research ; and on XI.15 a Masterclass on Transition from Paediatric to Adult Healthcare in Patients with GI or Liver Disease. For today’s discussion Jake has chosen a review of a small series of patients – from J Pediatr Gastroenterol Nutr, by D’Arienzo et al., “Characteristics and outcomes of home parenteral nutrition among children with...
2024-10-0123 min
ESPGHAN PodcastWaisbourd-Zinman O.: Unravelling the pathogenesis of biliary atresiaInterviewed today in the ESPGHAN podcast series is Dr Orit Waisbourd-Zinman, of Israel, who as a fellow in hepatology at the Children’s Hospital of Philadelphia was offered the chance to take part in studies of how “biliatresone”, a compound isolated from Australian plants (Dysphania sp.), might disrupt formation of extrahepatic biliary structures, as was postulated when sheep during drought ate unusual fodder, including Dysphania, and bore lambs that had biliary atresia. Extrahepatic cholangiocytes of mice and zebrafish given biliatresone had abnormal primary cilia (a glance of interest toward “syndromic” biliary atresia, with abnormalities of situs generally associated with ciliopathy, is...
2024-09-2021 min
ESPGHAN PodcastEscher H.: Tips and tricks for a successful transition, is there any evidence?Dr Johanna (“Henkje”) Escher speaks with me for ESPGHAN’s podcast series today. She works in learning how best to pass along the care of paediatric patients when, rather arbitrarily, they are declared to be adults. All very well, no adolescent wants to be a child forever, but . . . well, paediatric disorders, that is, those that manifest themselves in early life, cover a far wider spectrum than do those that are unmasked only in adulthood, and to have been ill (and designated thus) for sixteen, eighteen, twenty-one years is, for a patient, baggage that “adult gastroenterologists” may not readily help carry. I shou...
2024-09-1018 min
ESPGHAN PodcastJPGN Journal Club September 2024: Post-Transplant Pediatric IBD and Long-Term Outcomes in Autoimmune Sclerosing CholangitisJPGN Journal Club, led by Dr Jake Mann, is here again for August. As always, keep in mind ESPGHAN’s other educational offerings : https://www.espghan.org/knowledge-center – in particular on IX.12, AHP Summer School ; IX.21, the Young Investigator Forum ; IX.25, the 5th Liver Transplant School ; and X.25, a Monothematic Conference on Paediatric Gastric Disease. For today’s discussion Jake has chosen a case-review series of inflammatory bowel disease manifest after non-haematologic transplantation – from J Pediatr Gastroenterol Nutr, by Wenzel et al. – and from JHEP Reports, by Skarby et al., a long-term follow- up of children with autoimmune scleros...
2024-09-0127 min
ESPGHAN PodcastLanigan J.: Complementary feeding - new WHO guidelineInterviewed today in the ESPGHAN podcast series is Dr Julie Lanigan of University College London, working at several hospitals in London and lecturing in Plymouth, a dietitian whose interest is in complementary feeding (once called “weaning”, or the introduction of foods other than milk to an infant’s diet). Not just foods, but feeding, taking part in the activities that define the family – gaining a seat at the breakfast, lunch, and dinner table – goes into complementary feeding : Starting with new tastes, moving into new textures, and expanding beyond the sweet into the bitter or complex as the infant is socia...
2024-08-2020 min
ESPGHAN PodcastNorsa L.: Teduglutide in short bowel syndromeBergamascheria ancora! Yes, the Bergamo team have made available for a podcast yet another member, Dr Lorenzo Norsa, a professor of paediatrics there. Dr Norsa has been a fellow in paediatric gastroenterology in Israel and in France. In Paris he became well-versed in treatment of short bowel syndrome, working with the prominent Necker team . . . perhaps their publications form a suite Bergamasque. (Apologies, M Debussy.) He speaks today on the use of teduglutide, an agent that mimicks the effects of the small-bowel enterocyte mitotic stimulant and anti-apoptotic life-prolonger glucagon-like peptide 2. Teduglutide increases the number of functional enterocytes, lengthening villi and deepe...
2024-08-1020 min
ESPGHAN PodcastJPGN Journal Club August 2024: Pediatric Autoimmune Gastritis and Predicting Liver Fibrosis in MASLDIt’s JPGN Journal Club, led by Dr Jake Mann, in your electronic- device speakers, with the July podcast offering. Don’t forget to check out what ESPGHAN has available from July onward, here at https://www.espghan.org/knowledge-center -- in particular on IX.12, AHP Summer School, IX.21, the Young Investigator Forum, and on IX.25, the 5th Liver Transplant School. Jake Mann has chosen for today’s discussion from J Pediatr Gastroenterol Nutr, by Granot et al., a case review of instances of autoimmune gastritis and from Hepatology, by Lefere et al., description and derivation of a proposed “...
2024-08-0124 min
ESPGHAN PodcastMarra P.: The nick of time - an IR approach to managing upper GI bleedingThe ESPGHAN podcast guest today is Dr Paolo Marra – the interviewer, as our producer, Selma Ertl already has told you, is same old same old me – to round out the team, a hat-tip to Manuel Schuster, engineer. Let’s get starty with the party! So, Dr Marra – an interventional radiologist, and like everyone across from whom I sit in these sessions, amazingly young to have accomplished so much. He is an expert in how to deal with a not infrequent complication of premature birth – thrombosis of the external portal vein, a sequela of caregivers’ need for vascular access, via th...
2024-07-2023 min
ESPGHAN PodcastPapadopoulou A.: Pitfalls in the diagnosis and management of children with non-EoE EGIDsInterviewed today in the ESPGHAN podcast series is Hon. Prof. Dr. med. Alexandra Papadopoulou from Greece, Chair of the ESPGHAN Working Group and Special Interest Group on Eosinophilic Gastrointestinal Disorders for the last six years, Head of the Division of Gastroenterology, Hepatology and Nutrition of the First Department of Pediatrics of the National and Kapodistrian University of Athens and Head of the Department of Gastroenterology at the Athens Children's Hospital "Agia Sofia”. Among her interests is the entire spectrum of esophageal and extraesophageal diseases of the gastrointestinal tract characterized by eosinophilic leukocyte infiltration, tissue damage and dysfunction. Together with Pr...
2024-07-1021 min
ESPGHAN PodcastJPGN Journal Club July 2024: Intestinal Rehabilitation in Congenital Diarrhea and Biomarker-Based Prognosis After Pediatric Liver TransplantationJPGN Journal Club reporting for duty, sah! And mem! Here’s the spoken word about the written word . . . in a glorious June, with Heaven and Earth well and true in tune, as the poem goes. Don’t forget to check out what ESPGHAN has on offer from July onward, available at https://www.espghan.org/knowledge-center ! Dr Jake Mann has chosen for today’s discussion two heavy-hitting publications. The first, from J Pediatr Gastroenterol Nutr, by Cohen et al., addresses the value of intestinal-rehabilitation treatment in congenital diarrhoea; the second, from J Hepatol, by Chichelnitskiy, Goldschmidt, et al., demonstrates...
2024-07-0120 min
ESPGHAN PodcastAssa A.: New biologics and other new therapies for the treatment of IBDESPGHAN presents today an encounter with Prof Amit Assa, who like so many of those who have agreed to take part in these podcasts has filled all the posts of the medical-school and medical-administrative cursus honorum, steadily leaping upward from institution to institution. As of now he is at the Institute of Paediatric Gastroenterology, Shaare Zedek Medical Centre, in Jerusalem, Israel (affiliated with Hebrew University) ; his interests are concentrated on inflammatory bowel disease. Today he speaks about the modulation of small-molecule therapy, both increasing and decreasing, as disease is stabilized and wanes. Some patients, he says, respond to cort...
2024-06-2023 min
ESPGHAN PodcastKoot B.: MASLDToday’s ESPGHAN podcast offers the opportunity to become acquainted with the effects of a revision in nomenclature. Decades ago, stout – in both senses – Mormon matrons were vastly offended to learn that the form of steatohepatitis from which they suffered was histopathologically superimposeable upon that owing to ingestion of ethanol to excess ; the Word of Wisdom, a revelation vouchsafed in 1833 to Prophet Joseph Smith, expressly forbids ethanol to members of the Church of Jesus Christ of Latter-Day Saints, and the matrons swore up and down that they had forever been teetotal. The term “non-alcoholic fatty liver disease” thus was born.
2024-06-1023 min
ESPGHAN PodcastJPGN Journal Club June 2024: Anti-TNF Resistance in IBD and SIPR2 Pathways in Cholestasis with Prof Binita Kamath and Dr Jake MannJPGN Journal Club reports from the Milan venue of ESPGHAN’s 2024 annual meeting, seizing the opportunity to learn from those rarely in Europe – as today with Prof Binita Kamath, in transit between Toronto and Philadelphia professionally, who along with Dr Jake Mann will tag-team her way down the field shooting for goal with two articles of interest (Winter et al.’s Biomarkers predicting the effect of anti‐TNF treatment in paediatric and adult inflammatory bowel disease, from J Pediatr Gastroenterol Nutr 2024 May 2 doi: 10.1002/jpn3.12221, and Islam et al.’s A novel model to study mechanisms of cholestasis in human cholangiocyt...
2024-06-0118 min
ESPGHAN PodcastAnnual Meeting 2024 - Highlights from MilanO-makase is the word of the day, the phrase that in Japan tells your chef that your meal is both literally and metaphorically in her hands – “Choose for me,” it means. Most fine dining has an equivalent; the French say menu de dégustation, here in Milan / Mailand / Milano it’s called menù degustazione. That is: Non prevede scelte da parte del cliente! You, the diner, have no say. Either eat what’s set on the plate in front of you or stand up and leave the restaurant. O-makase, baby ! We hope you don’t leave, that is, switch off thi...
2024-05-1828 min
ESPGHAN PodcastVandenplas Y.: feeding disorders of infancy and in cows’-milk allergyDr Alex Knisely today speaks with Prof Yvan Vandenplas of Brussels, where he was chief of paediatrics for many years. He’s a hollow-viscus gastroenterologist rather than a “liver man”, and he has made many contributions in his chosen field, particularly in feeding disorders of infancy and in cows’-milk allergy, a topic on which he has selected three articles for us, all published in 2023 : From JPGN, “An ESPGHAN position paper on the diagnosis, management and prevention of cow's milk allergy”, with him as lead author, and (both by Meyer R et al.) from World Allergy Organization Journal, “World Allergy Organizati...
2024-05-1520 min
Der NeoCast: Update NeonatologieErnährung von Frühgeborenen - die neue ESPGHAN-Leitlinie mit Prof. Dr. Nadja Haiden
In der aktuellen Folge haben wir Prof. Dr. Nadja Haiden, Kinderärztin und Neonatologin, und aktuell Leiterin der Klinik für Neonatologie am Kepler Universitätsklinikum in Linz, zu Gast. Ein Schwerpunkt von Prof. Haidens klinisch-wissenschaftlicher Arbeit ist die Ernährung von Frühgeborenen, mit dem besonderen Fokus auf die Humanmilchforschung und wir sprechen mit ihr über die aktuellen ESPGHAN-Leitlinien. Prof. Haiden fasst für uns die Neuerungen der ESPGHAN-Leitlinie zusammen und gibt einen Überblick, wie die optimale Anreichung von Muttermilch aussieht. Außerdem hat Prof. Dr. Haiden Literaturempfehlungen mitgebracht und gibt jungen Kollegen oder Kolleginnen Tipps für ihre weite...
2024-05-0349 min
ESPGHAN PodcastJPGN Journal Club May 2024: Genetic Insights in Cystic Fibrosis Liver Disease and Linaclotide for Pediatric Functional ConstipationHere again is JPGN Journal Club. It’s Spring, people! Asparagus! Strawberries! White wine! All of these can be enjoyed as an ESPGHAN podcast listener, so let’s get at it : Raise your sauce béarnaise-laden forks, your Sancerre glasses, and your play-volume settings. Dr Jake Mann has chosen for today from Hepatology, by Stonebraker et al., Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis. Genomes of substantial numbers of CFTR disease patients, both with and without substantial liver disease (the former collected principally by centres in North Carolina and a centre In Ont...
2024-05-0124 min
ESPGHAN PodcastVogel G. F.: ileal bile-acid transport inhibitor, odevixibatDr. Alex Knisely today is talking to Dr. Georg-Friedrich Vogel – call him “Georg” – of the Medizinische Universität Innsbruck, in Austria, where he serves on the paediatric-hepatology wards and conducts research in the department of cell biology. In Vienna this May, at the ESPGHAN annual meeting, he presented observations on the utility of an ileal bile-acid transport inhibitor, odevixibat (those last four letters, i – b – a – t, are acronymic), in a collective of children suffering from cholestasis associated with ATP8B1 mutation (progressive familial intrahepatic cholestasis [PFIC], type 1) and from diarrhoea, metabolic acidosis, and allograft steatosis after liver transplantation. Although, as is t...
2024-04-1519 min
ESPGHAN PodcastJPGN Journal Club April 2024: Oral Vancomycin in PSC-IBD and Referral Patterns for Biliary Atresia in EuropeJPGN Journal Club is again here for you! No, no point in all that applause, although we’re grateful: Remember, we can’t hear it. As always, we’re glad to be back and we hope that you’re glad to have us back. Dr Jake Mann has chosen for today from Aliment Pharmacol Ther, by Ricciuto et al., Oral vancomycin is associated with improved inflammatory bowel disease clinical outcomes in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD) : A matched analysis from the Paediatric PSC Consortium. And the consortium? Centres, 54 ; PSC patients, 1,362 ; PSC-IBD patients, 1061 ; PSC patients studied, 113. In matched coh...
2024-04-0123 min
ESPGHAN PodcastScheers I.: pancreatitis in childrenDr Alex Knisely today is speaking with Prof Isabelle Scheers of Louvain, Belgium, on pancreatitis in children. She has proposed three articles for discussion – from a coalition that she led, drawing on collaborators in Canada, the United States, and almost the full bank of Eurovision Song Contest participant nations, a summary and review, Autoimmune Pancreatitis in Children : Characteristic Features, Diagnosis, and Management ; a personal “position paper”, Inherited Pancreatic Exocrine Insufficiency and Pancreatitis : When Children Transition to Adult Care ; and a rara avis case report with others from her home institution, Cinacalcet Sustainedly Prevents Pancreatitis in a Child with a Compound...
2024-03-1522 min
ESPGHAN PodcastJPGN Journal Club March 2024: Early-Life Diet and IBD Risk, and Early Immunosuppression in Pediatric Liver Transplant OutcomesJPGN Journal Club is in your ears again! We’re glad to be back and we hope that you’re glad to have us back. Dr Jake Mann has chosen for today from Gut, by Guo et al., early-life diet and risk of inflammatory bowel disease: A pooled study in two Scandinavian birth cohorts. This is the sort of thing that – thanks to the record-keeping in which the Northlands specialise – can’t be duplicated elsewhere but that indicates for us all how we can effectively address an aspect of disease. Fish, veggie and no sweet, sweet fizzy drinks for those babies...
2024-03-0119 min
ESPGHAN PodcastThomassen R. A.: FODMAPDr. Alex Knisely is talking today to Dr. Rut Anne Thomassen, of Oslo, who is a senior dietitian – one of only a few in the councils of ESPGHAN – and whose recent remit from ESPGHAN was to pull together a position paper that sets out for us all what is known in paediatric patients about a form of elimination-and- reïntroduction diet called FODMAP, an acronym that lists the classes of foodstuffs to be withdrawn. Some say that it works in some patients with irritable bowel syndrome . . . but consensus among caregivers as set out in Dr. Thomassen’s work is first...
2024-02-1522 min
ESPGHAN PodcastKolho K. L.: CalprotectinDr. Alex Knisely is talking today to Dr. Kaija-Leena Kolho, of Helsinki — they’ve orbited around each other for years, co-authoring this and that, but never met . . . in person or electronically, not until today, when they become good friends whilst discussing this podcast’s theme: Calprotectin. What is it? What does it do, in the body and in the diagnostic work-up? How can it be mis-used or mis-interpreted? And what superpowers does calprotectin confer upon the paediatric gastroenterologist who is confronted with YET ANOTHER sullen adolescent? Coming up: Calprotectin chat!
Dr. Kolho´s favourite song: Lintu - Suvi Teräsn...
2024-01-1526 min
ESPGHAN PodcastWali S.: intrahepatic cholestasisDr Alex Knisely today is speaking with Dr Sami Wali, of Riyadh, Saudi Arabia, senior attending gastroenterologist and chief of transplant hepatology at Prince Sultan Military Medical City. Dr Wali rose through the Saudi educational and medical-education systems, training at several Riyadh hospitals, with specialisation in paediatrics and in paediatric gastroenterology and hepatology that culminated in a year in Ontario at McMaster University and Hospital for Sick Children, Toronto – he is one of Prof Eve Roberts’ “old boys”. In Saudi Arabia many children with liver disease have metabolic disorders. Dr Wali has made large contributions to elucidating and to differen...
2024-01-0123 min
ESPGHAN PodcastAttard T.: video-capsule endoscopyToday we are speaking with Prof Thomas Attard, of the University of Missouri and Children’s Mercy Hospital of Kansas City, Missouri, where he directs gastrointestinal endoscopy services and leads the hereditary gastrointestinal polyposis multidisciplinary clinic. He is from Malta, where he studied medicine, although by far most of his career has been in the United States. At the 2023 ESPGHAN annual meeting in Vienna this May he presented his and his institution’s experience with video-capsule endoscopy in children with Peutz- Jeghers syndrome, in which hamartomatous polyps develop from stomach through large bowel, complicated by intussusception with obstruction of the...
2023-12-1525 min
ESPGHAN PodcastJPGN Journal Club December 2023: Pediatric Insulin Resistance, Acute Hepatitis, and Intrapyloric Botulinum Toxin TherapyToday we are not only speaking with Kassel’s best, Dr Andreas Jenke, but also with Dr Jake Mann, pride of Birmingham and the Channel Islands – that’s right, double trouble. We say thank you and goodbye to Andreas, thank you and hello to Jake, who is stepping into Andreas’ shoes as primary Journal Club discussant. Andreas leads off with Predicting Insulin Resistance in a Pediatric Population With Obesity, a JPGN article from Portugal, by Daniela Arauj́ o and colleagues, using non-invasive parameters to identify children at increased metabolic-syndrome risk and thereby perhaps opening restricted-prescription gateways for early pharmacologic interventi...
2023-12-0123 min
ESPGHAN PodcastMann J.: hepatobiliary diseaseDr Jake Mann, of the Children’s Hospital of Birmingham and the University of Birmingham is our guest today – Dr Mann’s second contribution to these podcasts. At the annual meeting of ESPGHAN in Vienna this May Dr Mann presented information on the potential relevance of genetic variants “of unknown significance”, the sort of thing that often is uncovered in exomic or genomic studies of children with hepatobiliary disease; one can’t pin the hepatobiliary disease on those variants, not exactly, but what is one to do with them? – to abnormalities in biomarker values assessed in adults. Indeed such variants and s...
2023-11-1517 min
ESPGHAN PodcastJPGN Journal Club November 2023: Pediatric H. pylori Resistance, Antenatal MgSO4, and Preterm Feeding DebatesDr Alex Knisely today in JPGN Journal Club is bantering happily with Dr Andreas Jenke, who for discussion has chosen two articles and a pair of Letters to the Editor, thrust and parry, attack and defence. He believes that correspondence of this sort often affords insight into what is at issue in the matter addressed – and he may well be right. Along with those, we have a contribution from Dr S Bonilla of Boston Children’s Hospital – Helicobacter pylori Antimicrobial Resistance Using Next-Generation Sequencing in Stool Samples in a Pediatric Population – and another from Dr B Özer Bekmez of Ankara C...
2023-11-0121 min
ESPGHAN PodcastDe Bruijn C. & Benninga M.: faecal transplantationTodays guests are Prof Marc Benninga and Dr Klaartje de Bruijn, both of Amsterdam’s Academisch Medisch Centrum. Prof Benninga is visiting these podcasts for a second time ; Dr de Bruijn is facing her baptism of fire. Their topic? Shudder and thrill – faecal transplantation. In 2020 their group published a protocol for faecal transplantation in adolescents with refractory irritable-bowel syndrome (PMID : 32864480), midway through the study described. In nuce : Healthy- donor stool or recipient’s own stool, delivered by nasoduodenal sonde immediately after irrigating the bowel clean from above, two doses six weeks apart ; both clinical well-being and stool microbiome assessed ; one-year...
2023-10-1521 min
ESPGHAN PodcastDhawan A.: acute liver failureOur todays guest is Prof. Anil Dhawan of King’s College Hospital in London, leader of the paediatric liver service there, about Prof. Dhawan’s lifelong especial interest within paediatric hepatology: Acute liver failure. In May, 2023, at the annual meeting of ESPGHAN, he sketched – from his personal vantage point – the horrorshow with which this clinical diagnosis confronted caregivers thirty-plus years ago; what steps have been taken to improve the prognosis of children with acute liver failure (they’re doing better now); and what remains to be accomplished for these children in both the near term and the longer term. He believe...
2023-09-1521 min
ESPGHAN PodcastJPGN Journal Club September 2023: Teduglutide in Pediatric Short Bowel Syndrome, Gastric Intestinal Metaplasia, and AIH Biopsy DebatesDr Alex Knisely today in JPGN Journal Club is – as usual ! -- speaking with Dr Andreas Jenke, who for discussion has chosen two full-size articles, call them “mains”, and a pair of linked items from among the “starters”, that is, a letter to the editors of the journal and a response from ESPGHAN. The two “mains” are Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support, from a coalition of Japanese, British, and Finnish centres supported by Takeda Yakuhin, makers of teduglutide, and, from Boston Children’s Hospital (USA), Gastric Intestinal Metaplasia in Ch...
2023-09-0123 min
ESPGHAN PodcastCantz T.: hepatocellular or cholangiocellular organoidsToday we are talking to Prof. Dr. Tobias Cantz, of Hanover / Hannover, Germany, on a topic that offers the chance to re-work many approaches to both acquired and inborn disease not just of the liver but also of the biliary tree. Prof. Cantz is a regenerative hepatologist, conducting research into how hepatocellular or cholangiocellular organoids – or, more complexly, organoids that include all the components of the differentiated and polarised and vascularised hepatic lobule – can be used to examine and to dissect how gene variants contribute to clinical disease, and how administration of organoids can contribute to repair of hepatobiliary inju...
2023-07-1522 min
ESPGHAN PodcastTzivinikos C.: Structure of aerodigestive program and management of common aerodigestive GI ConditionsTodays guest is Prof. Dr. Christos Tsivinikos of the Al Jalila Children’s Specialty Hospital, Dubai (United Arab Emirates), by way of Liverpool, UK, where he worked long-term. Over the past several years he and his colleagues have built up in Dubai not just a comprehensive paediatric gastroenterology and hepatology service but also an aerodigestive-diseases service, with collaboration from a variety of specialists in coördinated treatment of the complex problems that both underlie and arise from disorders of the organs and tissues of the concerned regions, and he is a powerful advocate for this approach to multisystem disease. For...
2023-06-0822 min
ESPGHAN PodcastTrauner M.: Therapeutic potential of bile acid signaling for Gastroenterology, Hepatology and NutritionDr. Alex Knisely is talking to, or with, or even maybe mostly listening to Prof. Dr. Michael Trauner, of Vienna – Professor Trauner has a lot to say on today’s topic, on which he recently provided the keynote address at the May, 2023, annual meeting of ESPGHAN. The topic is bile acids: They’re paracrine and endocrine hormones, not just lipid solubilisers ; modified versions offer promise in modulating and treating many paediatric and adult hepatobiliary and gastrointestinal processes and disorders ; in short, physiology has no magicks in which they are not involved. They are, taken together, a lapis philosophorum or rather h...
2023-06-0121 min
ESPGHAN PodcastCernat E.: Highlights ESPGHAN Annual Meeting 2023We are talking to Dr. Elena Cernat, of Leeds out of Romania, and the topic is oven-fresh : What was the 2023 annual meeting of ESPGHAN like? Elena last year gave us her opinions on interesting and very likely significant presentations at the previous annual meeting, and the Education Committee earlier this month again sent her out onto the convention floor to reconnoitre for more of the same. She came back lugging a sackful of those opinions, and she’ll share them with you in what you’re about to hear. Please note: This is the first of three podcasts related to a...
2023-05-2521 min
ESPGHAN PodcastJPGN Journaly Club March 2023: Metabolomic Profiling in Eosinophilic Esophagitis and Limitations of Abdominal X-Rays for ConstipationWe are talking to Dr. Andreas Jenke — Journal Club again! Two articles of particular interest and significance from the March, 2023, number of JPGN are discussed. One examines plasma constituents in children with untreated eosinophilic oesophagitis, mapping a wide range of small molecules. The “metabolomic profile” obtained is abnormal, but will any abnormalities resolve with successful treatment? Still waiting for that shoe to drop, and a long way to go before biomarkers are identified for clinical use. Until then, repeated endoscopy and biopsy are the best that we have. * * * The other reports, perhaps no surprise, that neither the experience that might accom...
2023-04-0119 min
ESPGHAN PodcastH. Szajewska: Research investigation of -bioticsWe are talking to Dr. Hania Szajewska of Warsaw, who as a newly fledged paediatric hepatogastroenterologist one day in Houston at a joint ESPGHAN / NASPGHAN meeting a few years back volunteered to collaborate in an international research investigation of -biotics (pro-, pre-, sym-, and post- are the flavours that she defines for us) and from then on has made the evidence-based study of these aids to establishing, maintaining, and restoring enteral health her high-flying career. Heady times, when central Europe had just embarked on remodelling her societies; all the long-closed doors flung wide open, among them those to ESPGHAN's co...
2023-03-0125 min
ESPGHAN PodcastV. McLin: Portosystemic vascular shuntsWe are talking to Prof. Valerie McLin of Geneva, Switzerland, where at the Hôpitaux universitaires de Genève she heads the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, about the clinically Protean — and thus as fascinating as they are challenging — disorders called portosystemic vascular shunts. Intrahepatic or extrahepatic, they all should be closed. But how are they to be recognized, assessed, and best closed? What resources are available to assist caregivers without specialized experience in offering their patients the best therapies for what certainly are uncommon problems? Beginning with diagnosis, which may come, for example, through discrepant results between t...
2023-02-1530 min
ESPGHAN PodcastJPGN Journal Club January 2023: Oral Immunotherapy and Eosinophilic Esophagitis, Plus Hypnotherapy in Functional GI DisordersDr. Alex Knisely is talking to Prof. Andreas Jenke — based in Kassel, Germany; but that’s less important today than is his position on the ESPGHAN Education Committee. Enough touchy-feely in these podcasts it’s Journal Club today, where two articles of particular interest and significance from the January, 2023, number of JPGN are discussed. Neither article, however, lays down the law: THIS IS WHAT TO DO. One, an immense retrospective study of oral immunotherapy and the chance that it might predispose to eosinophilic oesophagitis, is most of note for making clear what must now be addressed in prospective work. The othe...
2023-02-0122 min
ESPGHAN PodcastO. Abdrakhmanov: ESPGHAN in KazakhstanDr. Alex Knisely is talking to Dr. Olzhas Abdrakhmanov of the Scientific Centre of Pediatrics and Children’s Surgery, Almaty, Kazakhstan, until recently the nation’s capital (and still her premier city), about the hurdles and satisfactions of working as a paediatrician passionate about hepatogastroenterology who lacks the benefits of formal training in that discipline. His motto as he progressed through his twenties — he’s not yet into his fourth decade — has necessarily been “Learn from your patients”. Yes, from his patients, but not only them : From the resources, from the expertise, that ESPGHAN makes available world-wide. His good humour and determinati...
2023-01-1535 min
ESPGHAN PodcastA. Nita: Young ESPGHANWe are talking to Dr. Andreia Nita of Bucharest, Romania, and Great Ormond Street Hospital for Children, London, about her personal route into paediatric gastroenterology and about the opportunities that ESPGHAN, and particularly “Young ESPGHAN”, in which she is active — cut-off upper age forty, but for the right woman or man they’ll stretch a point — make available not only to trainees but also to the senior members of ESPGHAN who gain from mentoring those on the rise. Pairings between hopeful strivers and proven succeeders, hands-on training in case-report preparation and critical manuscript review, webinars to help stay au fait with pa...
2023-01-0132 min
ESPGHAN PodcastP. Bontems: Helicobacter pylori infectionDr. Alex Knisely is talking to Dr. Patrick Bontems of Hôpital Universitaire des Enfants Reine Fabiiola in Brussels / Brüssel / Bruxelles, Belgium, about Helicobacter pylori infection — how does one recognise it, diagnose it, treat it, and demonstrate success in treating it? What does one do with asymptomatic close family or social contacts? What about screening the asymptomatic in high-incidence populations? So much work on H. pylori has been published, and that work is so fragmentary, that most of us feel well over our heads in attempts to make sense of it, to distil it, to use it: But Dr B...
2022-12-1535 min
ESPGHAN PodcastGasparetto M: Paediatric inflammatory bowel diseaseWe are talking to Dr. Marco Gasparetto of Padua, Italy, and of Cambridge and East London, UK, about the prospects for genetically individualised treatment of paediatric inflammatory bowel disease. Brace yourselves for computational biology in pre-clinical validation studies. Also on the agenda, this question: for a devoted musician, did the move from Padua to Britain mean trading down? Featuring: Dr. Marco Gasparetto ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-10-0135 min
ESPGHAN PodcastD`Antiga L: Bilary disease after livertransplantationDr. Alex Knisely is talking to Dr. Lorenzo D ´Antiga of Bergamo about under-appreciated biliary disease after liver transplantation, the role of molecular studies in neonatal liver disease, and the long-ago shared times at King’s College Hospital before either man went grey : Liver disease and mis-spent youth . Featuring: Dr. Lorenzo D´Antiga ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-09-1537 min
ESPGHAN PodcastHill S: Small-bowel diseaseDr. Alex Knisely is talking to Dr. Susan Hill of London about small-bowel disease that requires long-term parenteral alimentation. Short-bowel problems and the need for teamwork among care-givers are the themes principally addressed. Featuring: Dr. Susan Hill ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-09-0134 min
ESPGHAN PodcastE. Cernat: ESPGHAN annual meeting highlightsElena Cernat, of Leeds, is back from Copenhagen, where she attended the 2022 annual meeting of ESPGHAN. She’s selected six presentations that intrigued her, presentations that to her represent advances on the clinical and on the basic-science fronts. She’ll now tell us what we should know about and why.
2022-07-1543 min
ESPGHAN PodcastZellos A.: Acute liver failureToday we’re privileged to hear Aglaia Zellos, of Athens, share her thoughts on the remarkably complex subject of acute liver failure in paediatric patients. We can only skim the surface of a topic worth an entire ESPGHAN conference and, so far, two summary papers — we may not address your favourite aspect — but we hope, and trust, that it will be interesting!
2022-07-0136 min
ESPGHAN PodcastDe Ridder L: Button BatteriesWe are talking to Dr Lissy de Ridder of Rotterdam about button batteries — we need them, but how do we reduce the threat that they pose to children and how do we best treat the ingestions that we haven’t been able to prevent? Featuring: Guest: Dr. Lissy de Ridder ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-06-1246 min
ESPGHAN PodcastSamyn M: New Hepatitis in childrenWe are talking to Dr Marianne Samyn of King’s College Hospital, London, about the so-called “new hepatitis” in children, with liver failure, that has attracted much media attention — what is known so far, what ESPGHAN resources and recommendations are available to physicians who have patients in whom this disorder is suspected? Featuring: Dr Marianne Samyn ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-06-0138 min
ESPGHAN PodcastJenke A: Necrotising enterocolitisToday we are talking to Prof. Andreas Jenke of Kassel in Germany about necrotising enterocolitis, the interplay of immunologic and other factors that lead to this complication of immaturity, and approaches — especially breast-milk feeding — that hold promise in prophylaxis against this disorder. Featuring: Prof. Andreas Jenke ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
2022-05-1525 min