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The Diagnostic MinuteMini-Review: Classification of Thymomas (0:12:03)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-07-2412 minThe Diagnostic Minute(AIQz500 Pathology of the Mediastinum) Sample Study Questions (0:20:24)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-07-2420 minThe Diagnostic MinuteMini-Review: Features of Specific Types of Thymoma (0:19:19)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-07-2419 minThe Diagnostic MinuteMini-Review: Mediastinal Tumors (0:22:403)Suggested Referenceshttps://pubmed.ncbi.nlm.nih.gov/34564969/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024054/ https://pubmed.ncbi.nlm.nih.gov/35227908/https://pubmed.ncbi.nlm.nih.gov/26295375/Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and ex...2025-07-2422 minThe Diagnostic MinuteMini-Review: Thymic Carcinomas (0:03:45)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-06-1803 minThe Diagnostic MinuteMini-Review: Thymomas, part-B (0:05:20)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-06-1805 minThe Diagnostic MinuteMini-Review: Thymomas, part-A (0:05:14)Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-06-1805 minThe Diagnostic Minute(AIQz500 Pathology of the Stomach) Sample Study Questions (0:19:18)This audio is complimentary material to study book "AIQz500 For Pathology of the Stomach" (2025). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided...2025-06-0119 minThe Diagnostic Minute(AIQz500 Pathology of the Stomach) Sample Study Questions (0:19:31)This audio content is complimentary material to study book "AIQz500 For Pathology of the Stomach" (2025). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information...2025-06-0119 minThe Diagnostic MinuteMini-Review: Esophagitis dissecans superficialis (EDS) (0:08:47)SummaryAsymptomatic or present with dysphagia, odynophagia, or regurgitationLongitudinal sloughing with intact underlying mucosa on endoscopySuperficial epithelial necrosis with intraepithelial splittingTwo-toned squamous epithelium: necrotic surface over viable basal layerMinimal inflammatory response despite extensive sloughingDisclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages...2025-05-2808 minThe Diagnostic Minute(AIQz500 Pathology of the Esophagus) Sample Study Questions (0:21:42)This audio content is complimentary material to study book "AIQz500 For Pathology of the Esophagus" (2025). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information...2025-05-2821 minThe Diagnostic MinuteReview: Non-mesothelial Spindle Cell Tumors of Pleura (0:25:21)Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-04-3025 minThe Diagnostic MinuteMini-Review: Esophagitis dissecans superficialis (EDS) (0:08:47)Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-04-3008 minThe Diagnostic MinuteReview: 2023 Guidelines for Mesothelioma Diagnosis (0:59:21)Husain AN, Chapel DB, Attanoos R, et al. (2024). Guidelines for Pathologic Diagnosis of Mesothelioma: 2023 Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch Pathol Lab Med. 148(11):1251-1271. doi:10.5858/arpa.2023-0304-RA Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses ar...2025-04-1459 minThe Diagnostic MinuteReview: Update on Diagnosis of Mesothelioma (0:17:13)Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-04-1417 minThe Diagnostic MinuteMini-Review: Molecular Classification of Gastric Adenocarcinomas (0:02:28)The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-03-2902 minThe Diagnostic MinuteMini-Review: Gastric Mesenchymal Tumors, Molecular Diagnosis (0:11:44)The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-03-2911 minThe Diagnostic MinuteMini-Review: Gastric Mesenchymal Tumors, Morphological Features (0:21:55)The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2025-03-2921 minThe Diagnostic MinuteIntroducing AIQz500 Book SeriesAIQz500 Book Series, presents 500 well formulated study questions in each volume designed to emulate the rigor of real-world diagnostic scenarios in pathology, helping sharpen skills essential for exam success and clinical readiness. AIQz500 turns study into effortless mastery, guiding readers toward comprehensive, exam-ready expertise and diagnostic confidence in diagnostic pathology.2025-03-2213 minThe Diagnostic Minute(AIQz500 Pathology of the Liver) Sample Study Questions (0:24:40)This audio content is complimentary material to study book "AIQz500 For Pathology of the Liver" (2025). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information...2025-01-2724 minThe Diagnostic Minute(AIQz500 Pathology of the Urinary Bladder) Sample Study Questions (0:21:15)This audio content is complimentary material to study book "AIQz500 For Pathology of the Urinary Bladder" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the...2025-01-0521 minThe Diagnostic Minute(AIQz500 Pathology of the Appendix) Sample Study Questions. part 02 (0:10:11)This audio content is complimentary material to study book "AIQz500 Pathology of the Appendix" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided...2025-01-0110 minThe Diagnostic Minute(AIQz500 Pathology of the Appendix) Sample Study Questions, Part 01 (0:10:52)This audio content is complimentary material to study book "AIQz500 Pathology of the Appendix" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided i...2025-01-0110 minThe Diagnostic MinuteReview: Urinary Bladder Carcinoma Variants, a narrative presentation (0:13:51)List of bladder Carcinoma variants presented in the review:Squamous Cell Bladder Carcinoma (SCC)Non-bilharzial-associated SCC (NB-SCC)Bladder adenocarcinomasPrimary bladder adenocarcinomaSecondary bladder adenocarcinomaIntestinal/enteric bladder adenocarcinomaClear cell adenocarcinomaSignet-ring cell adenocarcinomaUrachal adenocarcinomaMucinous urachal adenocarcinomaEnteric urachal adenocarcinomaSignet-ring cell urachal adenocarcinomaNon-urachal bladder adenocarcinomaHigh-grade neuroendocrine carcinomaPure small cell carcinoma (SmCC)Mixed histology SmCC (with UC, adenocarcinoma, or SCC)Bladder sarcomasLeiomyosarcoma of the bladderRhabdomyosarcomaAngiosarcomasUrothelial Carcinoma (UC) variantsUrothelial with squamous differentiationUrothelial with glandular differentiationPlasmacytoid/signet ring and lymphoma-likeUndifferentiatedLymphoepithelioma-like carcinomasClear cell...2024-12-1013 minThe Diagnostic MinuteReview: Urinary Bladder Carcinoma Variants, a conversational discussion (0:28:00)List of bladder cancer variants discussed in the review:Squamous Cell Bladder Carcinoma (SCC)Non-bilharzial-associated SCC (NB-SCC)Bladder adenocarcinomasPrimary bladder adenocarcinomaSecondary bladder adenocarcinomaIntestinal/enteric bladder adenocarcinomaClear cell adenocarcinomaSignet-ring cell adenocarcinomaUrachal adenocarcinomaMucinous urachal adenocarcinomaEnteric urachal adenocarcinomaSignet-ring cell urachal adenocarcinomaNon-urachal bladder adenocarcinomaHigh-grade neuroendocrine carcinomaPure small cell carcinoma (SmCC)Mixed histology SmCC (with UC, adenocarcinoma, or SCC)Bladder sarcomasLeiomyosarcoma of the bladderRhabdomyosarcomaAngiosarcomasUrothelial Carcinoma (UC) variantsUrothelial with squamous differentiationUrothelial with glandular differentiationNested variantMicrocystic variantMicropapillary variantPlasmacytoid/signet ring and...2024-12-1028 minThe Diagnostic MinuteReview: Non-Neoplastic Bone & Joint Diseases (0:25:36)List of diagnostic entities discussed in this episode:Reactive and Reparative BoneFracturesCement LinesEnthesesOsteonecrosisDegenerative Joint DiseaseLoose BodiesSuperficial Subarticular Insufficiency FracturesRapidly Progressive/Rapidly Destructive ArthritisMetabolic Bone DiseaseInfections (Osteomyelitis and Bone Abscesses)Marrow FibrosisNon-neoplastic Soft Tissue AbnormalitiesMorton's NeuromaTraumatic NeuromaSoft Tissue Masses that May Simulate TumorsGoutCalcium Pyrophosphate Deposition DiseaseHydroxyapatite Deposition Disease/Tumoral CalcinosisNeuropathic Joint/Charcot Joint2024-12-0825 minThe Diagnostic MinuteReview: Non-Neoplastic Bone & Joint Diseases (0:25:42)List of diagnostic entities discussed in this episode:Reactive and Reparative BoneFracturesCement LinesEnthesesOsteonecrosisDegenerative Joint DiseaseLoose BodiesSuperficial Subarticular Insufficiency FracturesRapidly Progressive/Rapidly Destructive ArthritisMetabolic Bone DiseaseInfections (Osteomyelitis and Bone Abscesses)Marrow FibrosisNon-neoplastic Soft Tissue AbnormalitiesMorton's NeuromaTraumatic NeuromaSoft Tissue Masses that May Simulate TumorsGoutCalcium Pyrophosphate Deposition DiseaseHydroxyapatite Deposition Disease/Tumoral CalcinosisNeuropathic Joint/Charcot Joint2024-12-0625 minThe Diagnostic MinutePathAffair: NIPBL-NACC1 Fusion in Cholangiocarcinoma (0:18:24)This audio content is from a pilot to test conversational audio podcast. Listeners should not rely on the information provided in the podcast to make medical decisions or justify any related test. Listeners should consult a qualified healthcare professional before making any medical decisions or taking any action based on the information provided in the podcast.No portion of this audio can be reproduced and/or distributed. All rights reserved. 2024-12-0118 minThe Diagnostic MinuteMiniReview: Intrahepatic cholangiocarcinoma (iCCA) (0:06:10)Feature Summary of iCCA in Keywords:Small duct iCCA: Mass forming. mucin-poor. CRP positive. BAP1, IDH1/2 mutation, and FGFR2 fusion.Large duct iCCA: geographic infiltrative. mucin-producing columnar epithelium. S100P-positive. Mutations in K -ras and SMAD4.Cholangioblastic cholangiocarcinoma: Women. young age. neuroendocrine-like cytology. inhinbin-positive. and NIPBL-NACC1 gene fusion.2024-11-2106 minThe Diagnostic Minute(AIQz500 Pathology of the Pancreas) Sample Study Questions, part-02 (0:10:11")DisclaimerThis audio content is complimentary material to study book "AIQz500 Pathology of the Pancreas" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse...2024-06-2210 minThe Diagnostic Minute(AIQz500 Pathology of the Pancreas) Sample Study Questions, part-01 (0:10:32")DisclaimerThis audio content is complimentary material to study book "AIQz500 Pathology of the Pancreas" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse...2024-06-2210 minThe Diagnostic MinuteAIQz500 Study Questions for Joint Pathology, part-01 (0:10:14")This audio content is complimentary material to study book "AIQz500 Pathology Questions of Joint" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved. Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of...2024-05-2910 minThe Diagnostic MinuteAIQz500 Study Questions for Joint Pathology, part-02 (0:10:46")This audio content is complimentary material to study book "AIQz500 Pathology Questions of Joint" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of...2024-05-2910 minThe Diagnostic Minute(AIQz500 Pathology of the Lung) Sample Study Questions, part-01 (0:11:41")This audio content is complimentary material to study book "AIQz500 Pathology of the Lung" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided...2024-04-2911 minThe Diagnostic Minute(AIQz500 Pathology of the Lung) Sample Study Questions, part-02 (0:11:36")This audio content is complimentary material to study book "AIQz500 Pathology of the Lung" (2024). No portion of this audio can be reproduced and/or distributed. All rights reserved.The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided...2024-04-2911 minThe Diagnostic MinuteSynopsis: Mucous gland adenoma of the lung (0:02:20")Key Feature Summary for Mucous gland adenoma: • Rare benign proximal endobronchial tumor • Airway obstruction symptoms common • Exophytic, mucoid endobronchial nodules • Cystic, acinar, tubular architecture • Bland mucous cell lining, no atypia • Positive for keratin, EMA, and CEA; low Ki-67 proliferation index• Main differential diagnosis: mucoepidermoid carcinoma, mucinous adenocarcinoma • Cured by complete resection2024-04-2902 minThe Diagnostic MinuteSynopsis: Mucinous Cystadenoma of the lung (0:01:57")Key Feature Summary for Mucinous Cystadenoma of the Lung: • Rare benign lung tumor usually found incidentally • Mean age 60s, slightly more in women• Mucin-filled cyst lined by bland mucinous epithelium • No atypia, invasion, or necrosis• Cytokeratin positive, and TTF1 negative • Differential diagnosis include: Metastatic adenocarcinoma, colloid carcinoma, bronchogenic cyst.• Cured by complete surgical excision2024-04-2901 minThe Diagnostic MinuteSnippet: Lung Adenocarcinoma, Grading & Behavior (0:02:25")In summary, lung adenocarcinoma grading is based on the predominant histological pattern. Immunophenotypes also reflect tumor behavior, but these immunophenotypic features are not incorporated in the current grading schema. 2024-04-2902 minThe Diagnostic MinuteSnippets: Pulmonary Small- vs Large-cell Neuroendocrine Carcinoma by IHC (0:02:20")Key Points:Small-cell (neuroendocrine) carcinoma tends to be Rb1-negative and cyclin D1-negative, while large-cell carcinomas are largely positive for Rb1 and/or cyclin D1. The use of this simplified expression pattern leads to a diagnostic accuracy of 97.3%. 2024-04-2902 minThe Diagnostic MinuteSynopsis: Adenocarcinoma in-situ (AIS) of the Lung (0:02:34")Key Feature Summary of Adenocarcinoma in situ (AIS)• Localized adenocarcinoma, ≤3 cm, • Ground glass nodule on CT • Lepidic growth of tumor cells along alveolar walls • Bland cytology without invasion • ≥50% EGFR mutation rate • 100% 5yr disease-free survival after complete resection2024-04-2902 minThe Diagnostic MinuteSynopsis: Papillary Adenoma of the Lung (0:02:29")Feature Summary of Papillary Adenoma of the Lung. •Exceedingly rare, benign peripheral lung tumor•Predominantly in man with wide age range•Circumscribed peripheral nodule•Papillary, fibrovascular cores•Single layer of bland lining epithelium•Positive for TTF1 and cytokeratins•Main differential diagnoses include alveolar adenoma, and adenocarcinoma•Complete resection curative2024-04-2902 minThe Diagnostic MinuteMini-Review: Immune Checkpoint Inhibitors (ICPI s) & Colitis (05:04")Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-04-1005 minThe Diagnostic MinuteMini-Review: Autoimmune Pancreatitis (Type I and Type II) (05:32")Feature Summary: There are two distinct subtypes of autoimmune pancreatitis (AIP).AIP-1: AIP-1 belongs to the group of IgG4-related diseases histologically characterized by storiform cellular fibrosis, obliterative phlebitis, and periductal chronic inflammation rich in IgG4-positive plasma cells.AIP-2: AIP-2: also known as idiopathic duct-centric pancreatitis, characterized by Ductal inflammation with intraepithelial neutrophils (so-called, granulocytic epithelial lesion), luminal neutrophilic abscesses, extensive fibrosis, but no apparent storiform or hypercellularity. 2024-04-1005 minThe Diagnostic MinuteMini-Review: Macroscopic Subtypes of Hepatocellular Carcinoma (05:15")SummaryHCC can be classified into five macroscopic types based on their gross morphology. They are associated with different extents of metastasis and thus different clinical outcomes.2024-04-0505 minThe Diagnostic MinuteMini-Review: Hepatoid Tumors (HTs) are not Hepatocellular Carcinoma (03:46")Feature Summary of Hepatoid TumorsHistologically similar to hepatocellular carcinoma (HCC) but arises outside the liver. Most commonly arise in the gastrointestinal tract and pancreaticobiliary system. Hepatocellular differentiation marked by positive immunostains for heppar-1, arginase-1, CD10 in canalicular pattern, and, to a greater extent, alfa-fetal protein and glypican-3. Largely classified as a form of adenocarcinoma rather than a specific entity. In contrast to hepatocellular carcinoma, they are positive for SALL-4, and CK19. Overall they are aggressive malignant neoplasm. 2024-04-0503 minThe Diagnostic MinuteSnippets Olfactory Carcinoma (01:02")Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-04-0501 minThe Diagnostic MinuteSynopsis: Cholangioblastic cholangiocarcinoma (02:29")Summary in KeywordYoung women. bimorphic cytology. positive for inhibin-A. unique NIPBL-NACC1 gene fusion.2024-04-0502 minThe Diagnostic MinuteSnippets: Intracholecystic & Intraductal Papillary Neoplasms of the Biliary Tree (02:22)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-02-2602 minThe Diagnostic MinuteSynopsis: Thymic Carcinomas (03:45)Feature Summary of Thymic Carcinomas Thymic carcinomas are histologically similar to their counterparts arising in other organ sites; and their diagnosis relies on 1) anterior mediastinal location, 2) lack of carcinoma of other organ sites, 3) co-existing lymphocytic component, and 4) immunophenotypes of thymic origin. 2024-02-2603 minThe Diagnostic MinuteMini-review: Cutaneous Melanocytic Tumor With CRTC1 & TRIM 11 Translocation (03:35)Feature Summary of CMTCT-- A novel pathologic entity of melanocytic origin,-- Variable positive immunostains for S100-protein, HMB45, and Melan-A.-- Diffusely positive stains for SOX10, MITF, and TRIM11-- CRTC1 & TRIM11 fusion is a signature genetic alteration.-- Seems to be a low-grade indolent tumor with malignant potential.2024-02-0703 minThe Diagnostic MinuteMini-Review: Gallbladder Carcinomas and Differential Diagnosis (05:02)Features of Gallbladder Carcinomas-- The fifth most common cancers of the gastrointestinal tract.-- Poor prognosis and very low overall 5-year survival rates of less than 5%. -- The most common type is adenocarcinomas.-- Adenocarcinomas usually are positive for IMP3, S100P, and Maspin.-- The pathologic staging differs from that of other carcinomas in the GI tract.2024-02-0705 minThe Diagnostic MinuteSnippets: Olfactory Carcinoma (01:02)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-02-0701 minThe Diagnostic MinuteSynopsis: Ovarian leydig cell tumor (0:01:55)Feature Summary of Ovarian leydig cell tumor: Well circumscribe solid nodule near ovarian hylum Fusion of cytoplasm to form nuclear-free zones is a key feature Cytoplasmic Reinke crystals and lipochrome pigments Fibrinoid material in blood vessels Typically positive for inhibin, calretinin, and mellan-A 2024-01-3001 minThe Diagnostic MinuteMini-Review: Ovarian Mucinous Tumors (05:01)Summary of Ovarian mucinous tumors (OMT)This mini-review highlights features of five forms of OMTs:1. Mucinous borderline tumor (MBT).2. MBT with microinvasion.3. MBT with intraepithelial carcinoma.4. Mucinous carcinoma with destructive infiltrative invasion.5. Mucinous carcinoma with confluent/expansile invasion. Ovarian mucinous carcinoma must be distinguished from metastatic carcinoma with mucinous differentiation.2024-01-3005 minThe Diagnostic MinuteMini-Review: Autoimmune Pancreatitis (Type I and Type II) (05:32)Summary of Autoimmune pancreatitisAutoimmune pancreatitis (AIP) is a chronic fibroinflammatory disease characterized by prompt response to steroid therapy. AIP presents as two distinct subtypes.AIP-1: AIP-1 belongs to the group of IgG4-related diseases histologically characterized by storiform cellular fibrosis, obliterative phlebitis, and periductal chronic inflammation rich in IgG4-positive plasma cells.AIP-2: AIP-2: also known as idiopathic duct-centric pancreatitis, characterized by Ductal inflammation with intraepithelial neutrophils (so-called, granulocytic epithelial lesion), luminal neutrophilic abscesses, extensive fibrosis, but no apparent storiform or hypercellularity. 2024-01-3005 minThe Diagnostic MinuteMini-Review: Hepatoid Tumors (HTs) are not Hepatocellular Carcinoma (03:46)Feature Summary of Hepatoid Tumors Histologically similar to hepatocellular carcinoma (HCC) but arises outside the liver. Most commonly arise in the gastrointestinal tract and pancreaticobiliary system. Hepatocellular differentiation marked by positive immunostains for heppar-1, arginase-1, CD10 in canalicular pattern, and, to a greater extent, alfa-fetal protein and glypican-3. Largely classified as a form of adenocarcinoma rather than a specific entity. In contrast to hepatocellular carcinoma, they are positive for SALL-4, and CK19. Overall they are aggressive malignant neoplasm. For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/2024-01-2403 minThe Diagnostic MinuteSynopsis: Papillary Adenoma of the Lung (02:29)Feature Summary of Papillary Adenoma Exceedingly rare, benign peripheral lung tumorPredominantly in man with wide age rangeCircumscribed peripheral nodulePapillary, fibrovascular coresSingle layer of bland lining epitheliumPositive for TTF1 and cytokeratinsMain differential diagnoses include alveolar adenoma, and adenocarcinomaComplete resection curativePlease visit us at: http://www.EssentialPathology.info 2024-01-2002 minThe Diagnostic MinuteSynopsis: Mucinous Cystadenoma of the lung (01:57)Key Feature Summary for Mucinous Cystadenoma of the Lung Rare benign lung tumor usually found incidentally Mean age 60s, slightly more in women Mucin-filled cyst lined by bland mucinous epithelium No atypia, invasion, or necrosis Cytokeratin positive, and TTF1 negative Differential diagnosis include: Metastatic adenocarcinoma, colloid carcinoma, bronchogenic cyst. Cured by complete surgical excisionPlease visit us at: http://www.EssentialPathology.info 2024-01-2001 minThe Diagnostic MinuteSynopsis: Mucous gland adenoma of the lung (02:20)Key Feature Summary for Mucous gland adenoma Rare benign proximal endobronchial tumor Airway obstruction symptoms common Exophytic, mucoid endobronchial nodules Cystic, acinar, tubular architecture Bland mucous cell lining, no atypia Positive for keratin, EMA, and CEA; low Ki-67 proliferation index Main differential diagnosis: mucoepidermoid carcinoma, mucinous adenocarcinoma Cured by complete resectionPlease visit us at: http://www.EssentialPathology.info 2024-01-2002 minThe Diagnostic MinuteSynopsis: Adenocarcinoma in-situ (AIS) of the Lung (02:34)Key Feature Summary of Adenocarcinoma in situ (AIS)Localized adenocarcinoma, ≤3 cm, Ground glass nodule on CT Lepidic growth of tumor cells along alveolar walls Bland cytology without invasion ≥50% EGFR mutation rate 100% 5yr disease-free survival after complete resectionPlease visit us at: http://www.EssentialPathology.info 2024-01-2002 minThe Diagnostic MinuteMini-Review: Thymoma (part-B) (05:20)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-01-1705 minThe Diagnostic MinuteMini-Review: Thymomas (part-A) (05:14)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-01-1705 minThe Diagnostic MinuteSynopsis: Thymic Micronodular Tumors with Lymphoid Hyperplasia (03:35)Feature Summary:The key contrasting features of micronodular thymoma (MT) and Micronodular thymic carcinoma (MTC) are cytological atypia, tumor necrosis, mitotic activities, intratumoral TdT-positive lymphocytes, CD5, CD117, and Glut-1 expression. 2024-01-1703 minThe Diagnostic MinuteMini-Review: Ovarian Serous Borderline Tumors (04:08)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2024-01-0904 minThe Diagnostic MinuteMini-Review: Breast Papillary Tumors (A Short Overview) (07:03)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast. 2024-01-0807 minThe Diagnostic MinuteMini-Review: Macroscopic Subtypes of Hepatocellular Carcinoma (05:15)SummaryHepatocellular carcinoma (HCC) can be classified into five macroscopic types based on their gross morphology. They are associated with different potential and extents of metastasis and thus different clinical outcomes.2024-01-0505 minThe Diagnostic MinuteSynopsis: Features of Adenoma-Like Colorectal Adenocarcinoma (03:03)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/ Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2023-12-3103 minThe Diagnostic MinuteSynopsis: Pancreatic Intraductal Tubulopapillary Neoplasm (ITPN) (01:45)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/ Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2023-12-2901 minThe Diagnostic MinuteSynopsis: Intraductal Oncocytic Papillary Neoplasm (IOPN) of the Pancreatobiliary System (03:37)Feature Summary of IOPN 1. A unique and rare intraductal papillary neoplasm of the pancreaticobiliary system. 2. confluent papillary growth of oncocytic cells with ample eosinophilic cytoplasm.3. Usually high-grade dysplasia, and 30% of cases harbor invasive carcinoma. 4. Positive for CD117 is a unique feature.5. Also positive for Muc-1, Muc-5AC and Muc-6. 6. PRKACA-B gene fusion is a distinct genetic hallmark. 7. Extremely favorable survival outcome after resection.2023-12-2803 minThe Diagnostic MinuteSnippets: Pulmonary Small- vs Large-cell Neuroendocrine Carcinoma by IHC. (02:20)Key PointSmall-cell (neuroendocrine) carcinoma tends to be Rb1-negative and cyclin D1-negative, while large-cell carcinomas are largely positive for Rb1 and/or cyclin D1. The use of this simplified expression pattern leads to a diagnostic accuracy of 97.3%. 2023-12-2302 minThe Diagnostic MinuteSnippets: Elastin Staining in Resected Colorectal Cancer (02:20)Key PointRoutine elastin staining allows for superior detection and prognostication of vascular invasion in colorectal cancer compared to H&E alone, with a two to threefold increase in vascular invasion detection with elastin stains.2023-12-2302 minThe Diagnostic MinuteSnippets: Epithelial Slackening in Endometrioid Carcinoma (01:39)For the transcript, the key references, and more, please visit us at: http://www.essentialpathology.info/ Disclaimer: The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at their own risk. By accessing the podcast, listeners agree to hold harmless EssentialPathology, NNMI, LLC, and its affiliates, from any and all claims, damages, and expenses arising from the use or misuse of the information provided in the podcast.2023-12-2201 minThe Diagnostic MinuteSnippets: Lung Adenocarcinoma, grading & Behavior (02:25)Summary Lung adenocarcinoma grading is based on the predominant histological pattern. Immunophenotypes also reflect tumor behavior, but these immunophenotypic features are not incorporated in the current grading schema. 2023-12-2002 minThe Diagnostic MinuteMini-Review: Assessment of Mucosal Mast Cells in Gastrointestinal Tract (04:25)Key Points of the Mini-ReviewMucosal mast cell assessment for unexplained GI symptoms or suspected systemic mastocytosis.In systemic mastocytosis, 62% exhibit endoscopic abnormalities; 66% biopsies confirm involvement (colon, ileum, duodenum).Specific architectural patterns and high mast cell counts support systemic GI mastocytosis.Clinical indications for assessment: Suspected systemic mastocytosis, unclear symptoms with abnormal endoscopic findings, markedly elevated serum IgE levels.2023-12-1804 min