Shows
This Is Why with Dr. BustiLAMA (Long-Acting Muscarinic Antagonists) Bronchodilators for COPDIn this lecture from This is Why, Dr. Busti will explain the COPD maintenance inhalers you’ll actually see in practice. In this pharmacology review, we break down LAMA (long-acting muscarinic antagonist) bronchodilators—one of the most important bronchodilator classes for COPD treatment—so you can confidently understand the drugs, the mechanism, and the real-world clinical use.You’ll learn how to:What LAMA / antimuscarinic bronchodilators are and how they workWhere LAMA inhalers fit in COPD therapy and long-term symptom controlKey differences and practical pearls for common COPD inhalersHigh-yield side effects, contraindications, and patient counseling pointsHow to recog...
2026-01-2725 minThis Is Why with Dr. BustiSAMA (Short-Acting Muscarinic Antagonists) Bronchodilator PharmacologyShort-acting muscarinic antagonists (SAMAs) are a core bronchodilator drug class you’ll see constantly in COPD care. In this lecture from This is Why, Dr. Busti will learn about short-acting muscarinic antagonists (SAMAs) are a core bronchodilator drug class you’ll see constantly in COPD care—and on exams like the NCLEX. In this lecture, you’ll learn exactly how SAMAs work, when to use them, and what safety pearls can help you avoid common clinical pitfalls in COPD.You’ll learn how to:Mechanism of action: muscarinic (M3) blockade → decreased bronchoconstrictionKey drug: ipratropium (Atrovent)Common combinations...
2026-01-2723 minThis Is Why with Dr. BustiGLP-1 Receptor Agonists (eg, Semaglutide) Diabetes Pharmacology ReviewUnderstand the GLP-1 receptor agonists—and why agents like semaglutide (Ozempic/Wegovy/Rybelsus), liraglutide, dulaglutide, and exenatide have become one of the most talked-about type 2 diabetes medications in modern practice. In this lecture from This is Why, Dr. Busti will break GLP-1s down in a clear, clinically relevant way so you can confidently explain how they work, when to use them, and what to watch for clinically when managing patients with type 2 diabetes and/or obesity.You’ll learn how to:- Mechanism of action: incretin mimetic effects (GLP-1) and what that...
2026-01-2746 minThis Is Why with Dr. BustiInsulin Types: Rapid, NPH, Basal for Diabetes - Pharmacology ReviewInsulin doesn’t have to be confusing when learning how to treat Type 1 and Type 2 diabetes mellitus. In this lecture from This is Why, Dr. Busti will explain how to quickly recognize insulin types, predict onset/peak/duration, and apply basal–bolus dosing concepts to real-world Type 1 and Type 2 diabetes care.You’ll learn how to:- How to identify rapid-, short-, intermediate-, and long-acting insulin for Diabetes- The difference between basal insulin vs bolus (mealtime) insulin- How basal–bolus regimens work (plus common pitfalls)- Prac...
2026-01-271h 00This Is Why with Dr. BustiMeglitinides (Nateglinide & Repaglinide): Diabetes Pharmacology ReviewMeglitinides (Nateglinide & Repaglinide) can feel like the “forgotten” oral diabetes drugs—but they show up on exams, in real-world medication histories, and in questions about postprandial glucose control and hypoglycemia and weight gain risk. In this lecture from This is Why, Dr. Busti will explain the meglitinides in a clear, clinically relevant way so you can recognize them quickly and use the concepts confidently in the context of Type 2 diabetes (T2DM).You’ll learn how to:- Meglitinides overview: where they fit in type 2 diabetes (T2DM) therapy- Drug nam...
2026-01-2712 minThis Is Why with Dr. BustiSGLT2 Inhibitors (eg, Empagliflozin) for Diabetes: Pharmacology ReviewSGLT2 inhibitors (bexagliflozin, canagliflozin, dapagliflozin, empagliflozin, ertugliflozin) don’t just lower glucose and A1C, but these meds have become relevant in cardiovascular disease and chronic kidney disease in the right patients also with type 2 diabetes (T2DM). In this lecture from This is Why, Dr. Busti will make the SGLT2 inhibitors make sense as they provide cardiorenal protection above their improvements in A1C.You’ll learn how to:- Mechanism of action (MOA): how SGLT2 blockade drives glucosuria, modest A1c reduction, weight loss, and BP lowering- Clin...
2026-01-2735 minThis Is Why with Dr. BustiSulfonylureas (Glyburide, Glipizide): Type 2 Diabetes PharmacologyDr. Busti covers one of the most-tested Type 2 diabetes drug classes—sulfonylureas. If you’ve ever mixed up glyburide vs glipizide, worried about hypoglycemia, or wanted a clear “when do I pick this?” framework, this drug class review is for you. In this lecture from This is Why, Dr. Busti will break down Sulfonylureas (Glyburide, Glipizide) step-by-step so you can confidently in the context of treating type 2 diabetes (T2DM).You’ll learn how to:- Mechanism of action: how sulfonylureas increase insulin release- Clinical use: where sulfonylureas still fit in mod...
2026-01-2721 minThis Is Why with Dr. BustiTZDs (Pioglitazone) for Type 2 Diabetes: Pharmacology ReviewIn this lecture from This is Why, Dr. Busti will break down pioglitazone and the thiazolidinediones (TZDs) so you can confidently explain the mechanism, clinical use, side effects, and key contraindications for type 2 diabetes (T2DM).You’ll learn how to:- TZDs (pioglitazone): where they fit in type 2 diabetes (T2DM) therapy- Mechanism of action: PPAR-γ agonist → increased insulin sensitivity (muscle/adipose) and improved glucose utilization- Expected impact on A1C reduction and how long these drugs take to show benefit- Practical compa...
2026-01-2715 minThis Is Why with Dr. BustiLABA (Long-Acting Beta Agonists) Bronchodilators for Asthma & COPDIn this lecture from This is Why, Dr. Busti will explain how Long-Acting Beta Agonists (LABAs) work, where they fit in therapy for the management of asthma and COPD.You’ll learn how to:- Mechanism of action: beta-2 receptor activation → bronchodilation (airway smooth muscle relaxation)- Clinical use: LABAs in COPD maintenance vs asthma (must be combined with ICS)- Onset/duration differences and practical inhaler considerations- Adverse effects & warnings: tachycardia, tremor, hypokalemia, paradoxical bronchospasm, and key safety concepts- Therapeutic combos: ICS...
2026-01-2736 minThis Is Why with Dr. BustiSABA (Short-Acting Beta Agonists) Bronchodilators for Asthma & COPDIn this lecture from This is Why, Dr. Busti will break down SABA (Short-Acting Beta Agonist) bronchodilators, like albuterol, for the acute management of asthma symptoms and COPD flare-ups.You’ll learn how to:- What SABAs are and when they’re used (rescue vs controller)- Beta-2 agonist mechanism of action (bronchodilation and smooth muscle effects)- How fast albuterol works, typical duration, and why it’s “short-acting”- Core therapeutic uses in asthma and COPD- How SABAs fit into treatment plans (including...
2026-01-2738 minThis Is Why with Dr. BustiAmylin Analogs (Pramlintide) for Diabetes: Pharmacology Made EasyAmylin Analogs (Pramlintide) for Diabetes: Pharmacology Made Easy. In this lecture from This is Why, Dr. Busti will explain how pramlintide (Symlin/SymlinPen) works and when it’s used as an adjunct to insulin for type 1 diabetes (and select type 2 diabetes cases). In this diabetes pharmacology review, I break down the mechanism of action of an amylin analog, why it helps postprandial glucose control, and the key clinical pearls you need for exams and practice.You’ll learn how to:- What amylin does physiologically and how pramlintide mimics it- How pramlintide lowers post-meal blood...
2026-01-2623 minThis Is Why with Dr. BustiTirzepatide (GIP/GLP-1 Agonists) for Diabetes: Pharmacology Made EasyTirzepatide (Mounjaro/Zepbound)—the dual incretin GIP/GLP-1 agonist—is a beneficial treatment of type 2 diabetes and/or obesity. In this lecture from This is Why, Dr. Busti will break down how tirzepatide works (MOA), why combining GIP + GLP-1 improves A1C reduction and supports weight loss, and where it fits in the treatment of type 2 diabetes. You’ll also get the high-yield points you need for exams and the bedside: tirzepatide dosing basics, common adverse effects, contraindications/precautions, and practical tips for patient counseling (nausea, GI effects, injection technique, and expectations).You’ll learn how to:- Tir...
2026-01-2631 minThis Is Why with Dr. BustiDPP-4 Inhibitors for Type 2 Diabetes: Pharmacology Made EasyIn this lecture from This is Why, Dr. Busti will learn about the application of DPP-4 inhibitors in the management of type 2 diabetes mellitus (T2DM). The DPP-4 inhibitors (e.g., sitagliptin, linagliptin, saxagliptin) have an impact of incretins (GIP, GLP-1) which have continued to evolve in other treatment options.You’ll learn how to:- Mechanism of action: DPP-4 inhibition and impact on incretins (GLP-1/GIP) - Key drugs: Sitagliptin, linagliptin, saxagliptin- Clinical role: where DPP-4 inhibitors fit in type 2 diabetes treatment, including add-on therapy- Adverse effects & safety pearls: the sid...
2026-01-2621 minThis Is Why with Dr. BustiMetformin - A Biguanide for Type 2 Diabetes: Pharmacology Made EasyMetformin is a first-line oral medication for type 2 diabetes. In this lecture from This is Why, Dr. Busti will explain how metformin works to lower the A1c and help patients with type 2 diabetes get to their A1C goals. You’ll learn how to:- Metformin mechanism of action (MOA): how biguanides lower glucose and improve insulin resistance- Where metformin fits in type 2 diabetes therapy (first-line option and combination use)- Key clinical benefits (A1C lowering, weight neutrality/possible weight loss)- Dosing basics and titration strategies (including extended-release considerations)...
2026-01-2631 minThis Is Why with Dr. BustiAlpha-Glucosidase Inhibitors for Diabetes: Pharmacology Made EasyIn this lecture from This is Why, Dr. Busti will teach you about Alpha-Glucosidase Inhibitors for Diabetes — the pharmacology made easy breakdown of acarbose and miglitol for type 2 diabetes.You’ll learn how to:- Explain how alpha-glucosidase inhibitors reduce postprandial hyperglycemia- Identify where these drugs work (GI tract) and why they don’t cause hypoglycemia by themselves- Compare acarbose vs miglitol (what’s similar, what’s different)- Recognize common GI adverse effects (e.g., flatulence, diarrhea, abdominal discomfort)- Know when they are (and are not) used in type 2 dia...
2026-01-2621 min
Medication TalkBONUS: Smoking and Vaping Cessation ConversationsIn this bonus episode of Medication Talk, join us for an extended conversation with our expert panel as we go beyond the original webinar and podcast episode to share brand-new insights and never-before-heard content.Listen in as we dive deeper into practical strategies for starting conversations with patients about tobacco use, plus additional perspectives on nicotine’s effects and health risks, emerging therapies, non-drug approaches, and how to make smoking cessation part of everyday pharmacy practice.**No CE Credit is available for this bonus episode.**Special guest:Robin Co...
2026-01-2227 minThis Is Why with Dr. BustiStatins (HMG-CoA Reductase Inhibitors): LDL Lowering Made EasyStatins (HMG-CoA Reductase Inhibitors) are the foundation of LDL lowering and ASCVD prevention. In this lecture from This is Why, Dr. Busti will make statin pharmacology easy to understand, but also clinically relevant in the proper context of the evidence. The use of HMG CoA reductase inhibitors: atorvastatin, rosuvastatin, simvastatin, pitavastatin, and pravastatin are drugs in this drug class that Dr. Busti will review. You’ll learn how to:MOA: How HMG-CoA reductase inhibitors reduce hepatic cholesterol synthesis and increase LDL clearanceClinical uses: Hyperlipidemia treatment, primary prevention, and secondary prevention for ASCVDHigh-yield statins: Atorvastatin, rosuvastatin, simvastatin, pra...
2026-01-201h 03This Is Why with Dr. BustiOmega-3 Fatty Acids (DHA, EPA): Pharmacology Made EasyOmega-3 fatty acids made easy: learn EPA vs DHA, how fish oil works, and when to use icosapent ethyl (Vascepa) in real clinical practice. In this lecture from This is Why, Dr. Busti connects PUFAs (polyunsaturated fatty acids) to outcomes, focusing on triglyceride lowering, cardiovascular risk reduction, and the key differences between OTC fish oil supplements and prescription EPA.You’ll learn how to:What omega-3 fatty acids (EPA & DHA) are and how they workFish oil (EPA vs DHA): what matters clinically (and what doesn’t)How omega-3s affect triglycerides and hypertriglyceridemiaIcosapent ethyl vs “fish oil”...
2026-01-2026 minThis Is Why with Dr. BustiFibrates (Fenofibrate & Gemfibrozil) for TG: Pharmacology Made EasyLearn fibrates (fibric acid derivatives)—fenofibrate and gemfibrozil—common triglyceride-lowering drugs for hypertriglyceridemia. In this lecture from This is Why, Dr. Busti will break down how fibrates (fenofibrate and gemfibrozil) work, when to use them, and the safety pearls you need for the patient with high triglycerides, which can lead to pancreatitis.You’ll learn how to:- Mechanism: PPAR-α activation → ↓ triglycerides (TG), ↓ VLDL, ↑ HDL- Fenofibrate vs gemfibrozil: key differences that matter for practice questions- Indications: managing high triglycerides (including reducing pancreatitis risk in severe TG)- Adverse effects & monitoring: myopathy risk, LFTs, gal...
2026-01-2029 minThis Is Why with Dr. BustiEzetimibe (Cholesterol Absorption Inhibitors): Pharmacology Made EasyIn this lecture from This is Why, Dr. Busti will break down Ezetimibe (Zetia)—the classic cholesterol absorption inhibitor—and make the pharmacology easy, high-yield, and clinically relevant. You’ll learn how ezetimibe lowers LDL-C, where it fits in dyslipidemia/hyperlipidemia therapy, and how it’s commonly used as add-on therapy to statins.You’ll learn how to:- Mechanism of action: how the cholesterol absorption inhibitor, ezetimibe, works to lower LDL cholesterol- Clinical use: when to use ezetimibe for LDL-C lowering (including statin add-on therapy)- Key benefits & limitations: what ezetimibe does well—and w...
2026-01-2033 minThis Is Why with Dr. BustiATP Citrate Lyase (ACL) Inhibitors: Bempedoic Acid ReviewATP Citrate Lyase (ACL) Inhibitors made simple. In this lecture from This is Why, Dr. Busti will provide you with a review of Bempedoic Acid (Nexletol), and you’ll learn how this lipid-lowering drug works, when to use it (including statin intolerance), and the key clinical pearls you need for exams and practice.You’ll learn how to:- What ATP citrate lyase inhibitors are and where they work in cholesterol synthesis- Bempedoic acid mechanism of action + why it’s different from statins- Effects on LDL cholesterol (LDL lowering drugs overview)- Indic...
2026-01-2029 minThis Is Why with Dr. BustiPlatelet Aggregation in Thrombosis: Clinical EssentialsPlatelet aggregation is a core step in hemostasis—and when it’s dysregulated, it drives thrombosis. In this lecture from This is Why, Dr. Busti will break down platelet physiology in a clear, clinically relevant way so you can understand how platelets form a primary hemostatic plug, how a thrombus develops, and why this process matters in real patient care.You’ll learn how to:- How platelet adhesion starts (the role of von Willebrand factor (vWF) and GPIb)- How platelet activation amplifies the response (ADP and thromboxane A2 / TXA2)
2026-01-1928 minThis Is Why with Dr. BustiCoagulation Cascade in Thrombosis: Physiology Made EasyDive into the coagulation cascade with this clear, clinically focused review! In this lecture from This is Why, Dr. Busti breaks down the coagulation cascade in a clear, clinically relevant way—perfect for healthcare professionals preparing for exams or patient care. Dr. Busti specifically covers the basics of hemostasis, the intrinsic and extrinsic pathways, clotting factors, vitamin K-dependent factors, thrombin functions, and how the cascade leads to thrombus formation (including key differences between venous and arterial thrombi). Learn "why" understanding normal physiology is essential for recognizing pathology and choosing the right interventions to prevent bleeding or thrombosis.
2026-01-1935 minThis Is Why with Dr. BustiP2Y12 Inhibitors (ADP Inhibitors): Antiplatelet Pharmacology Made EasyIn this lesson on P2Y12 inhibitors (ADP inhibitors), you’ll learn the high-yield, test-relevant concepts behind the most common antiplatelet drugs used in cardiovascular care. In this lecture from This is Why, Dr. Busti will break down how platelet aggregation inhibitors work, when they’re used clinically, and the key differences between clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), and cangrelor (Kengreal)—so you can apply the “why” behind therapy (not just memorize drug names).You’ll learn how to:- The P2Y12 (ADP) receptor and how blocking it reduces platelet activation
2026-01-1643 minThis Is Why with Dr. BustiGPIIb/IIIa Inhibitors: Antiplatelet Pharmacology Made Easy & RelevantIn this lesson on glycoprotein (GP) IIb/IIIa (GPIIb/IIIa) inhibitors, you’ll learn the high-yield, test-relevant concepts behind the adjunct antiplatelet drug therapy used in the acute management of patients experiencing an acute myocardial infarction (AMI; NSTEMI, STEMI) and undergoing PCI or coronary stent placement. In this lecture from This is Why, Dr. Busti will break down how platelet aggregation inhibitors work, when they’re used clinically, and the key differences between tirofiban and eptifibatide —so you can apply the “why” behind therapy (not just memorize drug names).You’ll learn how to:- The G...
2026-01-1617 minThis Is Why with Dr. BustiAspirin (ASA): Antiplatelet Pharmacology Made Easy & RelevantMaster Aspirin (ASA) fast with this Antiplatelet Pharmacology Made Easy & Relevant lecture. In this lecture from This is Why, Dr. Busti will make sure you learn how acetylsalicylic acid works as an antiplatelet drug, including COX-1 inhibition, decreased thromboxane A2 (TXA2), and reduced platelet aggregation—plus the key clinical takeaways for MI prevention, stroke prevention, and secondary prevention.You’ll learn how to:- Aspirin mechanism of action (COX inhibitor → ↓ TXA2 → ↓ platelet aggregation)- Why aspirin is different from other NSAIDs in antiplatelet therapy- High-yield uses in cardiovascular pharmacology (MI/stroke prevention)- Side effec...
2026-01-1543 minThis Is Why with Dr. BustiHeparins (UFH & LMWH): Pharmacology Made Easy & Clinically RelevantIn this lecture from This is Why, Dr. Busti will break down Heparin (UFH) and Low-Molecular-Weight Heparins (LMWHs), such as enoxaparin (Lovenox) and dalteparin (Fragmin), with a clear, clinically relevant approach. If you’re studying anticoagulation or need a fast refresher on anticoagulants, this video is for you.In this lesson, you’ll learn:- Heparin mechanism of action (UFH vs LMWH) + how they work in the clotting cascade- Monitoring & labs: aPTT/PTT for UFH, anti–Factor Xa concepts for LMWH- Dosing/administration pearls (IV vs SQ, onset/offset, bridging basics)- Adve...
2026-01-141h 00This Is Why with Dr. BustiWarfarin (Vitamin K Antagonist; VKA): Pharmacology Made EasyWarfarin (Vitamin K Antagonist; VKA) doesn’t have to be confusing. In this lecture from This is Why, Dr. Busti will explain warfarin's (Coumadin) pharmacology in a simple, clinically relevant way. It is perfect for anyone reviewing anticoagulation.You’ll learn how to:- Mechanism of action: how warfarin works as a vitamin K antagonist (VKA) (VKOR inhibition)- What PT/INR measures and why INR monitoring matters- How to start warfarin dosing (and what affects dose response)- Bridging with heparin/LMWH (warfarin bridge / heparin bridge) and when it’s needed...
2026-01-1436 minThis Is Why with Dr. BustiFactor Xa inhibitors (DOACs): Pharmacology Made Easy & RelevantFactor Xa inhibitors (DOACs) made easy—fast, clear, and clinically relevant. In this lecture from This is Why, Dr. Busti will break down direct oral anticoagulants (DOACs) and how Factor Xa inhibitors work, with relevance.You’ll learn how to:- What Factor Xa inhibitors do (mechanism of action)- Key drugs: Apixaban (Eliquis), Rivaroxaban (Xarelto), Edoxaban (Savaysa)- Common indications: Afib stroke prevention, DVT/PE treatment- Major adverse effects and safety: bleeding risk, interactions, and monitoring pearls- Reversal overview: What to know + when it mattersThe goal = make...
2026-01-1436 minThis Is Why with Dr. BustiDirect Thrombin inhibitors (DTI): Pharmacology Made Easy & RelevantDirect Thrombin Inhibitors (DTIs) made simple and clinically relevant! In this lecture from This is Why, Dr. Busti will help you master direct thrombin (Factor IIa) inhibitors—including the oral DTI dabigatran (Pradaxa) and key parenteral DTIs like bivalirudin (and where argatroban fits clinically, especially in the acute care setting)You’ll learn how to:- Where direct thrombin inhibitors work in the coagulation cascade- How dabigatran works (mechanism of action), major indications, and high-yield adverse effects- What to monitor, common drug interactions, and who is at higher bleeding risk- Dabi...
2026-01-1338 minThis Is Why with Dr. BustiCommunity-Acquired Pneumonia (CAP): Made Easy & Clinically RelevantIn this lecture from This is Why, Dr. Busti will make Community-Acquired Pneumonia (CAP) simple, practical, and clinically relevant—so you can confidently recognize CAP, assess severity, and choose the right pneumonia treatment.What you’ll learn:- How to approach CAP pneumonia like a clinician: presentation, diagnosis, and key differentials- How to assess severity using CURB-65 and the Pneumonia Severity Index (PSI score)- How to decide outpatient pneumonia vs inpatient pneumonia management- How to choose CAP antibiotics with guideline-based empiric antibiotics pneumonia sele...
2026-01-051h 00This Is Why with Dr. BustiAtrial Fibrillation: Made Easy & Clinically RelevantAtrial fibrillation (AFib) made easy—clinically relevant ECG/EKG interpretation, how to recognize AFib with RVR, and how to approach AFib management from bedside to boards.In this lecture from This is Why, Dr. Busti will , Dr. Busti breaks down atrial fibrillation in a clear, practical way so you can confidently answer:- What is AFib and why does it matter clinically?- How do you identify AFib on an ECG/EKG (classic “irregularly irregular” rhythm)?- When is it atrial fibrillation with RVR and what do you do fir...
2026-01-011h 08This Is Why with Dr. BustiSulfa Allergy: What Drugs to Avoid (and What’s Usually Safe)Sulfa allergy is one of the most commonly reported drug allergies (often cited around ~6% of patients), and it frequently leads clinicians to avoid entire medication classes—sometimes unnecessarily. In this lecture from This is Why, Dr. Busti will break down what drugs to avoid with a sulfa allergy (and what’s usually safe) by focusing on the “why”: the chemical features that drive true sulfonamide allergy risk and what that means for real-world prescribing.You’ll learn how to:- Identify what makes a drug a “sulfonamide”- Distinguish antimicrobial vs non-antimic...
2025-12-2713 minThis Is Why with Dr. BustiWhat is Odynophagia? Definition, Causes, & PitfallsIn this lecture from This is Why, Dr. Busti will break down the term odynophagia—how to pronounce it, how to use it correctly in charting and clinical conversation, and the most common conditions that cause swallowing pain (painful swallowing). This quick, high-yield refresher will help you confidently recognize and document odynophagia and avoid common mistakes (like confusing it with dysphagia).In this video you’ll learn:- What odynophagia means and how to say it- How it differs from dysphagia- Common causes of pain when swal...
2025-12-2612 minThis Is Why with Dr. BustiHeart Borders & Chambers on a Chest X-Ray - Made EasyIn this lecture from This is Why, Dr. Busti will make the identification of the heart borders and heart chambers on a chest x-ray easy. Dr. Busti will walk step-by-step through how to identify the cardiac silhouette, locate the heart borders, and understand where the right atrium, left atrium, right ventricle, left ventricle, left atrial appendage, and apex of the heart sit on a standard PA chest x-ray (CXR).You’ll see how to connect real heart xray images with the underlying heart anatomy.You’ll learn how to:- Identify normal heart borders on a...
2025-12-2316 minThis Is Why with Dr. BustiWhat is Dysphagia? Definition, Causes, & PitfallsIn this lecture from This is Why, Dr. Busti will break down dysphagia—the medical term for difficulty swallowing—in a clear, clinically relevant way. You’ll learn what dysphagia means, how clinicians use the term, and how to quickly recognize the difference between oropharyngeal dysphagia vs esophageal dysphagia. We’ll also cover high-yield dysphagia causes, red flags, and common pitfalls that lead to missed diagnoses—especially when aspiration risk is overlooked.What you’ll learn (quick + practical):- Dysphagia definition and how it shows up in real patients (“trouble swallowing)- Oropharyng...
2025-12-2312 minThis Is Why with Dr. BustiChest X-Ray Exposure: How to Tell If Your CXR Is AdequateAre you looking at a portable chest x-ray and wondering, “Is this exposure good enough to trust?” In this video, we walk through how to check chest x-ray exposure step-by-step so you can quickly decide if a CXR is adequately penetrated and ready for interpretation. In this lecture from This is Why, Dr. Busti will provide you with a practical approach to how to read chest x-rays and judge image quality before making clinical decisions.You’ll learn how to:Recognize adequate CXR penetration using the “spine through the heart” ruleApply a simple chest x-ray qual...
2025-12-2212 minThis Is Why with Dr. BustiHow to Easily Identify & Count Ribs on a Chest X-RayIn this lecture from This is Why, Dr. Busti will walk step-by-step through rib anatomy on a portable AP chest x ray, so you can quickly recognize posterior vs anterior ribs, assess inspiratory effort, and improve your overall chest x ray interpretation skills.You’ll learn how to:Spot posterior ribs and anterior ribs on a standard AP chest x rayUse rib counting to judge film quality and inspirationApply rib levels as landmarks when describing lung findingsAvoid common mistakes when reading portable chest x rays in the ER, ICU, and in...
2025-12-1913 minThis Is Why with Dr. BustiPenicillin Allergy & Cephalosporin Cross-ReactivityIn this lecture from This is Why, Dr. Busti will answer the question, "Are patients with a penicillin allergy really at high risk when we use cephalosporins?" Dr. Busti will also discuss some of the evidence on penicillin allergy & cephalosporin cross-reactivity and shows you how to safely use β-lactam antibiotics in clinical practice.In this episode, we’ll cover:- Why most penicillin allergy labels are incorrect- The true risk of cephalosporin cross-reactivity (and why it’s not what you think)- How R1 side chains drive cross-reactivity between β-lactam antibiotics- Practi...
2025-12-1913 minThis Is Why with Dr. BustiWhat Does Micturate Mean? Medical Terms Made Easy & RelevantWhat does “micturate” actually mean, and why do textbooks, exam questions, and older charts still use it instead of just saying “urinate”? In this lecture on Medical Terminology from This is Why, Dr. Busti breaks down the meaning and definition of micturate, how it relates to micturition and urination, and shows you exactly how this term is used in real clinical practice so it finally sticks.In this video, you’ll learn: what micturate and micturition mean in plain language, how to connect “micturate = urinate” so you never freeze on an exam, how the term shows up in phrases lik...
2025-12-1904 minThis Is Why with Dr. BustiPractice Question: Penicillin Allergy - Avoiding Cross-ReactivityMaster penicillin allergy questions exactly the way they show up on your exams and in clinical practice. In this episode of This is Why, Dr. Busti will walk through a high-yield practice question on penicillin allergy and beta-lactam cross-reactivity, so you know which antibiotics are safe, which to avoid, and how to reason through the stem under exam pressure.You’ll learn how to:- Analyze a penicillin allergy history in an exam-style MCQ- Understand penicillin–cephalosporin cross-reactivity and when it actually matters- Apply beta-lactam cross-reactivity concepts (penicillins vs. cephalosporins) to patient care...
2025-12-1807 minThis Is Why with Dr. BustiHow to Check Patient Positioning on a Chest X-RayMastering chest X-ray positioning is the first step to safe and accurate chest X-ray interpretation. In this video, “How to Check Patient Positioning on a Chest X-Ray,” Dr. Busti walk through a simple, practical checklist so you can quickly decide if a CXR is good enough to interpret—or if positioning errors (rotation, poor inspiration, clipping) are misleading you.You’ll learn how to:Tell PA vs AP views and why it matters for heart size and mediastinumSpot patient rotation using the clavicles and spinous processesAssess inspiration on a chest X-ray (how many rib...
2025-12-1616 minThis Is Why with Dr. BustiAP vs PA Chest X-Ray: How to Tell the DifferenceIn this lecture from This is Why, Dr. Busti will teach you how to quickly and confidently tell AP vs PA chest X-ray (CXR) views apart so you don’t get misled by magnified hearts or a widened mediastinum. In this video, we break down chest X-ray projection step by step and show you how to spot whether a film is AP or PA view just by looking at the image itself—skills you can use on your next shift or exam.This teaching video is designed to help clinicians who want practical, bedside chest X-ray interpretation skil...
2025-12-0513 minThis Is Why with Dr. BustiHow to Tell If Chest X-Ray Inspiration Is Adequate (Portable CXR Tips)In this lecture from This is Why, Dr. Busti will walk step-by-step through the proper steps to determine if the inspiration is good enough to allow the chest x-ray (CXR) to be appropriate to interpret and avoid missing an abnormality. This lecture will improve your overall chest x-ray interpretation skills.You’ll learn how to:Identify the posterior ribs and anterior ribs on a standard AP chest x rayUse rib counting to judge film quality and inspirationIf you’re looking for a clear, visual guide to how to read a chest x ray...
2025-12-0410 minThis Is Why with Dr. BustiSSRI Antidepressants: Pharmacology Made Easy & Clinically RelevantIn this This Is Why pharmacology review, Dr. Busti walks through the Selective Serotonin Reuptake Inhibitors (SSRIs)—how they became first-line for major depressive disorder and a wide range of anxiety-related disorders, and where their real-world pitfalls live.We compare the core agents—citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline—covering indications, mechanism, and clinical nuances that matter at the bedside. You’ll learn how dose, half-life, metabolism, and side-effect patterns influence patient-specific choices, and what to monitor for safety and success.This episode includes practical guidance on:Managing sexual dysfunction, QT risk, and SIADHRec...
2025-11-2034 minThis Is Why with Dr. BustiChest X-Rays: How to Read Like a Pro - A Step-by-Step GuideThis session teaches a reproducible, step-by-step approach to chest X-ray (CXR) interpretation using two complementary mnemonics: RIPE (Rotation, Inspiration, Penetration/Projection, Exposure/Artifacts) to verify image quality, and A-B-C-D-E-F-G-H-I to read findings in a consistent order. Viewers learn to spot essential landmarks (trachea, aortic knob, hila, lobes/fissures, diaphragms, costophrenic angles), recognize when AP vs PA matters (e.g., cardiothoracic ratio), and avoid common pitfalls that lead to misses. A live, real-time read ties the method together so the approach can be used on rounds, in clinic, or at the bedside.What...
2025-11-1139 minThis Is Why with Dr. BustiChest X-Rays: How to Read Like a Pro - A Step-by-Step GuideThis session teaches a reproducible, step-by-step approach to chest X-ray (CXR) interpretation using two complementary mnemonics: RIPE (Rotation, Inspiration, Penetration/Projection, Exposure/Artifacts) to verify image quality, and A-B-C-D-E-F-G-H-I to read findings in a consistent order. Viewers learn to spot essential landmarks (trachea, aortic knob, hila, lobes/fissures, diaphragms, costophrenic angles), recognize when AP vs PA matters (e.g., cardiothoracic ratio), and avoid common pitfalls that lead to misses. A live, real-time read ties the method together so the approach can be used on rounds, in clinic, or at the bedside.What...
2025-11-1141 minThis Is Why with Dr. BustiPredicting Your NCLEX-RN Success: Why Some Pass & Some Don'tIn this episode of This Is Why, Dr. Busti breaks down the evidence-based predictors of NCLEX-RN success for first-time test takers. See what the 10-year pass-rate trend really shows, which factors (GPA, standardized exit exams, program environment, life experience) matter most, and—most importantly—what you can do now to raise your odds on test day.Build confidence in your exam readiness and clinical mastery with free resources at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to p...
2025-11-1108 minThis Is Why with Dr. BustiBPS Exam Pass Rates & Predictors of Success: How to Improve Your OddsBPS specialty board exams are challenging — and the data proves it. But knowing what drives success can make all the difference.In this episode of This Is Why, Dr. Busti reviews national BPS pass rate trends and explores what separates first-time test takers who succeed from those who don’t. Using data from multiple specialties, he highlights how residency training, study strategy, and preparation methods predict success — and why relying solely on memorization or guesswork fails so many candidates.You’ll learn how to interpret your own readiness, avoid common traps like overemphasizing blueprints or anecdota...
2025-10-2714 minThis Is Why with Dr. BustiBPS Exams: Study What is Testable to Maximize SuccessPassing a BPS specialty exam takes more than hard work — it takes strategy and understanding.In this episode of This Is Why, Dr. Busti breaks down how BPS exams are built, what “testable” really means, and why focusing on validated, evidence-based concepts gives you a major advantage. Drawing on decades of experience as a pharmacist, educator, and exam review developer, he explains the multi-step process used to create fair, reliable, and job-related BPS exams.Listeners will learn why not all new or clinically relevant content appears on the test, how to interpret the exam blueprint effect...
2025-10-2714 minThis Is Why with Dr. BustiPredicting Your NAPLEX Success: How to Boost Your First-Time Pass RateWhat predicts success on the NAPLEX? It’s not chance — it’s about understanding the factors that matter most.In this episode of This Is Why, Dr. Busti unpacks the key predictors of NAPLEX performance based on data and published literature. You’ll learn how GPA, pre-admission metrics, clinical performance, study effort, and test timing correlate with first-time pass rates — and how to interpret these factors to improve your own odds.Drawing from decades of experience teaching pharmacy and preparing students for licensing exams, Dr. Busti helps listeners identify what’s within their control and how to act o...
2025-10-2709 minThis Is Why with Dr. BustiStudy Smarter for the NAPLEX: What’s Really Testable?The NAPLEX isn’t testing everything you’ve ever learned — it’s measuring what matters most for entry-level pharmacist competence.In this episode of This Is Why, Dr. Busti explains how the NAPLEX is built by the NABP, why understanding its blueprint helps you focus your studying, and how to avoid wasting time on untested or emerging content. Drawing on his own experience as a pharmacist, physician, and nurse — and decades teaching pharmacy students — he reveals the process behind question validation, exam updates, and psychometric testing.Listeners will learn how to identify high-yield, testable concepts that align w...
2025-10-2712 minThis Is Why with Dr. BustiWhy NAPLEX Scores are Low & How to Reverse the TrendOver the past decade, NAPLEX pass rates have dropped — sparking concern across pharmacy education. But what’s really driving this decline?In this episode of This Is Why, Dr. Busti breaks down the data behind NAPLEX performance trends, exploring factors such as the rapid growth of pharmacy schools, shifts in applicant pools, and the impact of the COVID-19 pandemic on learning and assessment.Drawing from decades of experience as a pharmacist, physician, and nurse, Dr. Busti helps listeners understand how these changes have shaped the profession — and what students can do to overcome them. You’ll learn...
2025-10-2713 minThis Is Why with Dr. BustiNCLEX-RN: Study Smarter, Pass Faster: : Focus on What MattersPassing the NCLEX-RN isn’t about memorizing more — it’s about understanding what truly matters and how the exam is built to measure it. In this episode of This Is Why, Dr. Busti, a physician and pharmacist who began his healthcare career as a registered nurse, breaks down how the NCLEX-RN is developed by the National Council of State Boards of Nursing (NCSBN) — and what that means for your study plan.You’ll learn how to recognize high-yield, testable concepts, why some new content won’t appear on the exam, and how to focus your preparation on what can act...
2025-10-2708 minThis Is Why with Dr. BustiPractice Question: Pneumonia Treatment - As Seen on Your ExamsIn this episode of This Is Why, Dr. Busti walks through a real-world board-style question on community-acquired pneumonia — connecting core pathophysiology to exam reasoning and clinical judgment. Using a 54-year-old patient case, you’ll learn how to differentiate inpatient versus outpatient management, apply CURB-65 and PSI scoring tools, and identify sepsis criteria that drive treatment decisions.Dr. Busti also unpacks the rationale behind antibiotic selection, comparing macrolide monotherapy, beta-lactam combinations, and fluoroquinolone alternatives — all while reinforcing how understanding why each answer choice is correct or incorrect leads to long-term mastery.If you’re preparing for your boa...
2025-10-0721 minThis Is Why with Dr. BustiSmoking Cessation Agents: Pharmacology Made Easy & Clinically RelevantDr. Busti reviews pharmacologic options for smoking cessation—bupropion, nicotine replacement therapy, and varenicline—highlighting mechanisms, dosing strategies, and safety considerations. Learn how to integrate these therapies with behavioral approaches, tailor choices to patient comorbidities, and monitor for clinically relevant risks.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advi...
2025-10-0735 minThis Is Why with Dr. BustiTCA Antidepressants: Pharmacology Made Easy & Clinically RelevantDr. Busti reviews selective serotonin reuptake inhibitors (SSRIs)—their mechanism, first-line indications, key side effects, and clinical pearls. Learn why SSRIs are widely used for depression and anxiety, how to avoid pitfalls like QT prolongation and drug interactions, and what to monitor to optimize patient care.Access bonus materials and downloads at https://thisiswhy.healthFind resources for this topic at https://www.thisiswhy.health/topics/pharmacology-review-tca-tricyclic-antidepressantsDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or...
2025-10-0734 minThis Is Why with Dr. BustiTCAs (Tricyclic Antidepressants): Uses, Risks & Practical MonitoringDr. Busti reviews tricyclic antidepressants (TCAs)—their history, evolving role, and why they remain relevant today. Learn how tertiary vs. secondary amines differ, why lower doses are effective for pain and insomnia, and how overdose risks tie back to sodium channel blockade. Practical monitoring, counseling tips, and clinical pearls are highlighted to help you apply TCAs safely and effectively.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or ot...
2025-10-0739 minThis Is Why with Dr. BustiSNRI Antidepressants: Pharmacology Made Easy & Clinically RelevantDiscover serotonin-norepinephrine reuptake inhibitors (SNRIs)—safe, effective antidepressants for depression, anxiety, and pain syndromes. In this episode, you’ll learn:- How SNRIs work in the brain and differ from SSRIs, TCAs, and MAOIs- Key medications: venlafaxine, desvenlafaxine, duloxetine, milnacipran, levomilnacipran- Important side effects, including blood pressure changes and SIADH in older adults- Tips for safe switching, monitoring, and counseling patientsCompanion tables (indications, mechanisms, PK/PD, side-effect grid, and monitoring prompts) are available for download and teaching at https://www.thisiswhy.health/topics/pharmacology-review-snri-antidepressantsDisclaimer: This...
2025-10-0729 minThis Is Why with Dr. BustiAtypical Antidepressants: Pharmacology Made Easy & Clinically RelevantDr. Busti explores the atypical antidepressants—bupropion, mirtazapine, trazodone, vilazodone, and vortioxetine. Learn how these agents differ from SSRIs/SNRIs, when to use them, and how their unique side effect profiles can actually guide therapy.Access tables, visuals, and playlists for this episode at https://www.thisiswhy.health/topics/pharmacology-review-atypical-antidepressantsDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical ad...
2025-10-0736 minThis Is Why with Dr. BustiMAOI Antidepressants: Pharmacology Made Easy & Clinically RelevantDr. Busti breaks down monoamine oxidase inhibitors (MAOIs)—where they still fit in modern care, how they work, and how to use them safely.In this episode you’ll learn:Why MAOIs remain relevant for treatment-resistant depressionHow irreversible MAO-A/B inhibition elevates serotonin, norepinephrine, and dopaminePractical washout rules (why 14 days after MAOI, generally 7 days before starting an MAOI; longer with fluoxetine)High-yield differences (e.g., selegiline transdermal for depression vs. oral formulations for Parkinson’s disease)Key drug–drug risks (serotonergic agents, certain opioids like tramadol, linezolid/methylene blue)Tyramine-containing foods and counseling to prevent hypertensive crisis
2025-10-0737 minThis Is Why with Dr. BustiProton Pump Inhibitors (PPI): Pharmacology Made Easy & Clinically RelevantDr. Busti reviews Proton Pump Inhibitors (PPIs)—how they work, why they outperformed H2 blockers, key clinical uses, and important risks. From GERD to GI bleeds, learn the why behind PPIs so you can apply them safely in practice.Access tables, visuals, and playlists for this video at https://www.thisiswhy.health/topics/pharmacology-review-proton-pump-inhibitors-ppiDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Ne...
2025-10-0748 minThis Is Why with Dr. BustiInhaled Corticosteroids: Pharmacology Made Easy & Clinically RelevantA practical pharmacology review of inhaled corticosteroids (ICS) in asthma and COPD. Dr. Busti explains why ICS are first-line therapy in asthma, their selective role in COPD, key mechanisms, dosing strategies, side effects, and patient counseling points to improve adherence and outcomes.Access downloads for this episode at https://www.thisiswhy.health/topics/pharmacology-review-inhaled-corticosteroids-asthma-copdDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition...
2025-10-0744 minThis Is Why with Dr. BustiPotassium-Competitive Acid Blockers (PCAB): Pharmacology Made Easy & Clinically RelevantIn this episode of This Is Why, Dr. Busti unpacks the pharmacology and clinical relevance of the potassium-competitive acid blocker (P-CAB) class—featuring vonoprazan, the newest option in acid suppression therapy.You’ll learn how P-CABs compare to H₂ receptor antagonists and proton pump inhibitors (PPIs) in terms of mechanism, onset, and duration of acid control. Dr. Busti explains the unique pharmacodynamic and pharmacokinetic properties that make vonoprazan a valuable alternative for patients who do not adequately respond to PPIs.The discussion connects the drug’s molecular action a...
2025-10-0737 minThis Is Why with Dr. BustiStep 4 and 5 Apply and Assess: Where Evidence Meets UnderstandingThe final two steps of Evidence-Based Medicine—Apply and Assess—focus on turning knowledge into better patient outcomes. Dr. Busti explains how to apply evidence to real-world practice, integrate patient preferences, and assess the impact of your decisions to continually improve care. Discover how adapting your approach over time creates a more patient-centered, evidence-driven practice.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your phys...
2025-10-0616 minThis Is Why with Dr. BustiThyroid Hormone Replacement: Pharmacology Made Easy & Clinical RelevantLevothyroxine is first-line for hypothyroidism, but getting it right requires precision. In this episode, Dr. Busti explains the TSH–T4–T3 feedback loop, why T4 is preferred over T3 or desiccated thyroid, and how half-life and protein binding shape dosing and monitoring. We cover steady-state timing (6–8 weeks), dose step sizes, manufacturer switches, and how food and cation supplements (calcium, iron, magnesium) alter absorption. You’ll also learn how anticonvulsants, rifampin, beta-blockers, steroids, and amiodarone affect levels or peripheral conversion.Special populations receive focused guidance: immediate dose increases in pregnancy, careful titration in cardiovascular disease, and intentional TSH suppress...
2025-10-0644 minThis Is Why with Dr. BustiEBM in Real Life: When I Didn’t Know the “Why” (Deep Dive)In this personal reflection, Dr. Busti shares a formative moment of cognitive dissonance that reshaped his approach to evidence-based medicine. When a simple question exposed a knowledge gap, it sparked a lifelong commitment to understanding the “why” behind clinical decisions—and to teaching with honesty and humility.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medica...
2025-10-0615 minThis Is Why with Dr. BustiCognitive Resonance vs Dissonance: Turning Gaps into GrowthCognitive dissonance—the moment we realize we don’t know something we should—can either hinder or grow us. In this episode, Dr. Busti explains how understanding and managing dissonance within the Evidence-Based Medicine framework strengthens humility, reflection, and better patient care. Learn to turn uncertainty into growth and develop true cognitive resonance.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other...
2025-10-0618 minThis Is Why with Dr. BustiStep 3 Appraise the Evidence: Where Evidence Meets UnderstandingStep 3 of Evidence-Based Medicine focuses on appraising the evidence. Dr. Busti explains how to systematically evaluate research using validated critical appraisal tools (CATs), detect bias, and interpret the quality of data before applying it to patient care. Learn to distinguish strong evidence from weak studies and develop a reliable, reproducible process for evidence-based decision-making.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician...
2025-10-0621 minThis Is Why with Dr. BustiStep 2 Acquire the Best Evidence: Where Evidence Meets UnderstandingStep 2 of the EBM process is all about how to acquire evidence efficiently. Dr. Busti explains how to turn your PICO question into an effective search strategy, use Boolean logic and MESH terms, and select the best databases for your clinical question. Learn to differentiate primary, secondary, and tertiary literature and find the most relevant evidence quickly without missing key studies.Access bonus materials and downloads at https://thisiswhy.healthDisclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek...
2025-10-0638 minThis Is Why with Dr. BustiStep 1 Ask a Clinical Question: Where Evidence Meets UnderstandingEvidence-Based Medicine (EBM) has been shaping clinical decision-making for more than three decades. In this episode, Dr. Busti walks through Step 1 of the 5 A’s — Ask, focusing on how to craft clear, answerable clinical questions that drive better evidence searches and stronger patient care decisions.You’ll learn the difference between background and foreground questions, explore the structure of PICO (Population, Intervention, Comparison, Outcome), and understand how extensions like PICOT and PICOTS add precision by incorporating time and setting. Using practical clinical examples—from asthma and hypertension to acute coronary syndromes—Dr. Busti demonstrates how well-formed questions save time...
2025-10-0627 minThis Is Why with Dr. BustiThiazide Diuretics: Pharmacology Made Easy & Clinical RelevantThiazide diuretics have been essential in managing hypertension and remain one of the most widely prescribed drug classes today. But their value becomes clearer when you understand the “why.”In this episode, Dr. Busti explains the mechanism of thiazides at the distal convoluted tubule, how this drives sodium handling, and why their clinical effects differ from loop diuretics. We cover the key agents — hydrochlorothiazide, chlorthalidone, indapamide, and metolazone — and discuss their use in hypertension, edema, and special populations.Practical insights include why chlorthalidone often has stronger evidence than HCTZ, why higher HCTZ doses don’t yield more...
2025-10-061h 03This Is Why with Dr. BustiLoop Diuretics: Pharmacology Made Easy & Clinically RelevantMRAs—spironolactone, eplerenone, and finerenone—do far more than nudge blood pressure. They improve outcomes in heart failure, offer targeted benefits in CKD with T2D, and play a unique role in cirrhosis-related ascites. In this focused review, Dr. Busti walks through the why behind the what: aldosterone receptor blockade, tissue selectivity (kidney vs heart), and how those differences drive real-world choices, dosing, and safety.We compare agents head-to-head, unpack RAAS physiology, and translate it into exam-ready pearls and bedside judgment—covering hyperkalemia risk, gynecomastia, CYP3A4 interactions, ACEi/ARB combinations, and how to counsel on potassium-containing salt s...
2025-10-061h 12This Is Why with Dr. BustiMineralocorticoid Receptor Antagonists: Pharmacology Made Easy & Clinically RelevantMRAs—spironolactone, eplerenone, and finerenone—do far more than nudge blood pressure. They improve outcomes in heart failure, offer targeted benefits in CKD with T2D, and play a unique role in cirrhosis-related ascites. In this focused review, Dr. Busti walks through the why behind the what: aldosterone receptor blockade, tissue selectivity (kidney vs heart), and how those differences drive real-world choices, dosing, and safety.We compare agents head-to-head, unpack RAAS physiology, and translate it into exam-ready pearls and bedside judgment—covering hyperkalemia risk, gynecomastia, CYP3A4 interactions, ACEi/ARB combinations, and how to counsel on potassium-containing salt s...
2025-10-061h 01This Is Why with Dr. BustiH2 Receptor Antagonist Antacids (H2RA): Pharmacology Made Easy & Clinically RelevantH₂ receptor antagonists like famotidine and cimetidine have been around for decades, but they still play an important role in managing GERD, dyspepsia, ulcers, and even acute GI bleeding. In this episode, Dr. Busti reviews the history, pharmacology, and clinical relevance of this class, including the withdrawal of ranitidine.You’ll learn how H₂ blockers fit into the larger category of antacid therapy, why they’re effective for mild cases but limited in long-term control, and how tolerance can reduce effectiveness. Cimetidine’s drug interaction profile is explored in detail, including CYP450 effects and alcohol metabolism. Practical dosing con...
2025-10-0642 minThis Is Why with Dr. BustiWelcome to This is Why with Dr. BustiIn this introductory episode of This Is Why, Dr. Busti shares the powerful story behind the creation of the podcast — and the mission driving it. With over 30 years of experience spanning nursing, pharmacy, medicine, and education, Dr. Busti offers a rare 360-degree perspective on healthcare.He discusses the common gap in medical training: being taught what to do and how to do it, but not always why. Through his own journey — from the ICU and emergency department to academic medicine and beyond — Dr. Busti explains how understanding the “why” transforms clinical decision-making, patient outcomes, and professional confidence.Liste...
2025-10-0605 minMedication TalkBiosimilars in ActionListen in as we discuss considerations, challenges, and strategies related to the use and switching of biosimilars in clinical practice. You’ll hear communication tips to address patient and prescriber concerns as well as operational considerations for integrating biosimilars into practice. Special guests:Bharati Bhardwaja, PharmD, BCPS, LSSBBRheumatology Clinical Pharmacy SpecialistKaiser Permanente ColoradoMegan May, PharmD, BCOP, FHOPA, FAPOClinical Oncology Pharmacy SpecialistBaptist Health Lexington/Hamburg Cancer Care CenterYou’ll also hear practical advice from TRC’s Editorial Advisory Board member:Craig D. Williams, PharmD, FNLA, BCPSClinical Professor of Pharmacy PracticeOregon Health and Science...
2025-10-0131 minThis Is Why with Dr. BustiWhy EBM Is So Hard - And Why It MattersEvidence-Based Medicine (EBM) is a cornerstone of clinical training, but why is it so difficult to practice and teach consistently? In this deep dive, Dr. Busti unpacks the foundation of EBM, the five A’s, and why application often falls short in practice. Drawing from his training at Oxford and years of teaching across medicine, pharmacy, and nursing, he highlights misconceptions, barriers, and practical strategies to bridge the gap between evidence, education, and patient care.This episode also uses a real-world case example—the ISIS-2 trial of aspirin in acute myocardial infarction—to illustrate how evidence should be und...
2025-09-2938 minThis Is Why with Dr. BustiWhat is EBM & EBM Terminology: Where Evidence Meets UnderstandingIn this kickoff episode on Evidence-Based Medicine (EBM), Dr. Busti explains what EBM is—and what it isn’t. You’ll learn why the classic Venn diagram (evidence, expertise, and patient factors) matters, and how the "Five A’s"—Ask, Acquire, Appraise, Apply, Assess—create a practical framework for clinical decision-making. We also unpack related terms like evidence-based practice, practitioner, and expert, showing how they fit together and why balance between literature, training, and patient preferences is essential. Perfect for students and early-career clinicians ready to ground their practice in the why behind the how.Access the video plus b...
2025-09-2928 min
The Bull of Wall Street#41 - Dr. Matthew Schwartz, MD and Dr. Thomas Dayspring, MD, FACP, FNLA on Cancer Innovation, Cardiovascular Disease Prevention, and What Everyone Needs to Know (recorded 09/15/25)Health is wealth, and as advisors the impact we make extends beyond portfolios. In this two-part episode, Jimmy Lee first sits down with his good friend Dr. Matthew Schwartz, radiation oncologist and UNLV faculty member, to explore how proteomics is changing cancer treatment. Then Dr. Thomas Dayspring, one of the world’s foremost educators on lipids and mentor to Dr. Peter Attia, explains why cardiovascular disease remains the number one preventable cause of death, plus the simple blood tests and treatments that can save lives.Disclaimer: This episode is for informational purposes only and does not constitute medical ad...
2025-09-151h 43Medication TalkMeds After Acute Coronary SyndromeListen in as our expert panel discusses the latest recommendations for managing medications after heart attacks and other cardiac events. You’ll hear our panelists review which antiplatelets to use, the optimal blood pressure meds, and the role of statin and non-statin cholesterol meds.Special guests:Danielle Blais, PharmD, FCCP, BCCP, BCPSCardiology Lead Specialty Practice PharmacistRichard M. Ross Heart HospitalThe Ohio State University Wexner Medical CenterJoel C. Marrs, PharmD, MPH., BCACP, BCCP, BCPS, FAHA, FASHP, FCCP, FNLAProfessor and Coordinator of Clinical OutreachThe University of Tennessee Health Science CenterDepartment of Clinical Pharmacy & Translational ScienceYou’ll also...
2025-09-0132 minMedication TalkAntidepressant InsightsListen in as our expert panel discusses practical considerations for starting and optimizing antidepressants for treating depression and anxiety. You’ll listen to panelists cover various aspects of antidepressant use, such as serotonin syndrome, QT prolongation, and weight gain concerns.Special guests:Tammie Lee Demler, BS, PharmD, MBA, BCGP, BCPP Director of Pharmacy and Residency Programs, New York State Office of Mental Health State University of New York at Buffalo School of Pharmacy and Pharmaceutical Sciences Sarah E. Grady, PharmD, BCPS, BCPPProfessor, Drake University College of Pharmacy and Health SciencesClinical Pharmacist, Inpatient Behavioral Health Unit, Broadlawns Medica...
2025-07-0138 minMedication TalkMeds for Alzheimer DementiaListen in as our expert panel discusses medications for the treatment of Alzheimer dementia. They'll review the risks and benefits of cholinesterase inhibitors, memantine, and the anti-amyloid monoclonal antibodies. And you’ll hear strategies for managing behavioral and psychological symptoms of dementia. Special guests:Tatyana Gurvich, PharmD, BCGP, APhAssociate Professor of Clinical PharmacyMann USC School of PharmacyUCI Senior Health CenterCandace Pierce, DNP, RN, CNE, COINurse Educator, Nurse Planner, and Healthcare Leader, Colibri HealthcareDarlene Moyer, MD, FAAFPAssociate Director, HonorHealth Family Medicine Residency ProgramAssociate Professor of Clinical Practice – SOMME – Arizona State UniversityClinical Associate Professor – University of Arizona College of Medicine...
2025-06-0134 minMedication TalkMedications for Opioid Use DisorderListen in as our expert panel discusses medications for management of opioid use disorder. They’ll review strategies to optimize buprenorphine use and clarify the role of methadone and naltrexone.Special guest:Tyler J. Varisco, PharmD, PhDUniversity of Houston College of Pharmacy Assistant Professor, Department of Pharmaceutical Health Outcomes and PolicyAssistant Director, The PREMIER CenterYou’ll also hear practical advice from panelists on TRC’s Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLM, Clinical Associate Professor of Family Medicine for the Prisma Health/USC School of Medicine Greenville Family Medicine Residency Program at the Uni...
2025-05-0137 minMedication TalkBronchitis and Pneumonia TreatmentIn this episode, listen in as our expert panel digs into identifying and treating acute bronchitis and community-acquired pneumonia. They’ll discuss when antibiotics are appropriate, which antibiotics to use, and other management tips.You’ll also hear practical advice from panelists on TRC’s Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLM, Program Director for the Prisma Health/USC School of Medicine Greenville Family Medicine Residency Program and Clinical Associate Professor at the University of South Carolina School of Medicine, GreenvilleAndrea Darby Stewart, MD, Associate Director, Honor Health Family Medicine Residency Program and Clinical Professor of Fam...
2025-03-0134 minMedication TalkAsthma and COPD TreatmentSpecial guest Lori A. Wilken, PharmD, FCCP, BCACP, NCTTP, AE-C, Clinical Assistant Professor in the Department of Pharmacy Practice at the University of Illinois, Chicago, joins us to talk about Asthma and COPD treatment.Listen in as we discuss answers to your big questions about treatment of asthma and COPD. You’ll also hear practical advice from panelists on TRC’s Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLM, Clinical Assistant Professor of Family Medicine, Prisma Health/USC-SOMG Family Medicine Residency Program at the USC School of Medicine GreenvilleAndrea Darby Stewart, MD, Assoc...
2024-10-0135 minMedication TalkPrecepting: Helping Learners SucceedIn this episode, listen in as our expert panelists discuss tips for creating successful learning experiences for students and residents. We’ll review various teaching tools and summarize strategies for incorporating learners into your practice. We’ll also discuss different approaches for providing meaningful feedback and managing challenging situations with learners.Our panel for this conversation includes: Andrea Darby Stewart, MD; Associate Director, Honor Health Family Medicine Residency Program; Clinical Professor of Family, Community & Occupational Medicine, University of Arizona College of Medicine – PhoenixMary Franks, MSN, APRN-FPA, FNP-C; Nurse Planner, NetCE; Adjunct Professor, Bradley University; Nurse Practitioner, Carle He...
2024-09-0147 min
South African Border WarsEpisode 17 – The SAS Steyn’s role in the remarkable evacuation from the beach at AmbrizetteThis is episode 17 and we’re approaching the end of Operation Savannah which had started out so well but was rapidly turning into a strategic nightmare for the South Africans.
One of the fastest mechanised invasions since World War Two had resulted in the SADF now deep into Angola – and in the case of Brigadier Roos who was a liaison officer based in Ambriz with the FNLA – he was cut off on the coast to the north of the capital Luanda.
IT was mid-November 1975 and the MPLA and Cubans were starting to move determined to rid the co...
2021-06-2119 minSouth African Border WarsEpisode 16 – Luanda’s “Death Road” leaves the FNLA in tatters and the CIA decides to up and offThis is episode 16 and we’re covering Operation Savannah which took place between October and December 1975.
That was the invasion of southern Angola by the South African Defence Force in response to the outbreak of a civil war in the country involving the three main independence movements that had fought against Portuguese colonial rule.
These were the MPLA, Unita and the FNLA. Our focus in this episode shifts in a while to the FNLA’s assault on the Capital Luanda.
But first an update about the SADF.
Brigadier Schoeman who was in char...
2021-06-1418 min
iUniverseBrian Scott Edwards, MD, FNLA, S. T. Byra and Leo CauzilloiUniverse Radio order of interviews for show: 3:00-4:00PM EST 1. “The Chronic Disease of Obesity: How Sponge Syndrome Causes Repeated Weight Gain”; by Brian Scott Edwards, MD, FNLA 2. “One and One Is One: The Beginning”; by S. T. Byra 3. “They are Not Alone: Mythology or History”; by Leo Cauzillo
2019-06-1047 min
The Peter Attia DriveTom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and moreIn this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. In Part V, Peter and Tom talk about inflammation, endothelial health, and oxidative stress as they pertain to cardiovascular disease, and our attempts to monitor them using biomarkers. They also discuss a couple of very important risk factors that too few people (and doctors) know about. Tom closes the five-part series with a tragic story about his good friend that is likely all-too-common for many practicing...
2018-10-191h 29