Shows
The CIRS Group PodcastThe Hidden Link Between HLA-B27 and CIRS (no one’s talking about this)For more info and support, visit us over at https://thecirsgroup.com
In this episode of The CIRS Group podcast, hosts Barbara and Jacie dive into the specifics of ankylosing spondylitis, an autoimmune condition that Jacie personally struggled with. They discuss the genetic aspects tied to the HLA-B27 gene and its role in autoimmune disorders, including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and inflammatory bowel disease. Jacie shares a detailed account of her rapid symptom progression and how treatment for CIRS (chronic inflammatory response syndrome) brought her significant relief. The episode highlights the overlap between CIRS...
2025-10-1522 minThe CIRS Group PodcastThe Hidden Link Between HLA-B27 and CIRS (no one’s talking about this)For more info and support, visit us over at https://thecirsgroup.com
In this episode of The CIRS Group podcast, hosts Barbara and Jacie dive into the specifics of ankylosing spondylitis, an autoimmune condition that Jacie personally struggled with. They discuss the genetic aspects tied to the HLA-B27 gene and its role in autoimmune disorders, including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and inflammatory bowel disease. Jacie shares a detailed account of her rapid symptom progression and how treatment for CIRS (chronic inflammatory response syndrome) brought her significant relief. The episode highlights the overlap between CIRS...
2025-10-1522 min
The HLA: The Ripple EffectJosephine Elliott: Paediatrics, Academia, and The HLA LeadershipJosephine Elliott, a paediatrician and former scholar from the third cohort of The Healthcare Leadership Academy (HLA), reflects on her career journey and the impact of the programme. She recounts her initial reluctance to apply for The HLA, despite encouragement from a peer, because she felt unqualified. However, she explains how the programme significantly boosted her confidence and inspired her to pursue an Academic Clinical Fellowship (ACF) in paediatric genetics.Josephine also describes her project as a board assistant for the European Junior Doctors Association, an experience that offered valuable exposure to international collaboration and leadership. She...
2025-10-0739 min
Kermode on FilmBrian Cox, Michelle Gomez, Kate Dickie on MK3D at the Edinburgh FestivalThis episode is the very first edition of MK3D recorded in Edinburgh, as part of the Edinburgh International Book Festival. Mark Kermode talks to three iconic Scottish actors: Brian Cox, whose directorial debut Glenrothan opens later this year. Kate Dickie, who is currently on Netflix in Department Q, and Michelle Gomez, BAFTA-nominated for her role as Missy in Doctor Who.Sit back and enjoy this MK3D show recorded live at McEwan Hall in Edinburgh.With thanks to Charlotte Matheson at HLA and Lilidh Kendrick and Jenny Niven and the whole, brilliant te...
2025-08-1958 min
Coffee & CompatibilityThe past, present and future, of the HLA database that HLA laboratories CANNOT survive without!Whether you work in an HLA lab or rely on one for clinical services or care, you won’t want to miss this episode of Coffee & Compatibility! James Robinson, founder of the bioinformation IPD-IMGT/HLA Database, joins us to share how this essential tool evolved into a global resource with over 74,000 submissions, 42,000+ alleles, and nearly 20 new entries every day!
2025-06-3037 min
Rare ConnectionOrphan Disease of HLA-B27 With Brenda From FloridaSend us a textIn this episode, I sit down with Brenda, a woman navigating the challenges of a painful, disabling, and unnamed orphan disease. Despite testing negative for VEXAS, relapsing polychondritis, and MAGIC syndrome, Brenda continues to suffer from spontaneous tendon tears and systemic inflammation. One key clue? She is HLA-B27 positive, a genetic marker linked to certain autoimmune conditions — but her exact diagnosis remains elusive. 💡 In this episode, you’ll learn:What HLA-B27 is and why it matters in autoimmu...
2025-05-2953 min
Kermode on FilmShining a spotlight on the BFDG Planet Positive Award, and making the industry sustainableKermode on Film supports the British Film Designers Guild Awards – and shines a spotlight on the BFDG Planet Positive Award sponsored by Sky Studios Elstree. In this episode Mark Kermode talks to the winner of that award, Freya Bruce, co-founder of ReCollective, about their work on 'My Lady Jayne'. ReCollective are a non-for-profit, setting new standards of re-use for the film industry to tackle the enormous amount of waste it produces. ReCollective's work on 'My Lady Jane' involved repurposing building materials which were then used for community builds in the South West of Engl...
2025-04-0123 minThe HLA: The Ripple EffectJim Determeijer: A global health PhD candidate and former HLA scholar.This podcast features an interview with Jim Determeijer, a global health PhD candidate and former HLA scholar. The conversation centres on Jim's unique journey, highlighting his experiences as one of the early international HLA scholars, his pivotal role in expanding The HLA's global reach, and his current PhD research on family participation in healthcare within resource-limited settings.Jim emphasises the importance of building inclusive communities and fostering collaboration across diverse backgrounds and disciplines, showcasing these values both in his HLA involvement and his impactful global health research. The interview concludes with reflections on Jim's leadership style, highlighting...
2025-03-0645 minThe HLA: The Ripple EffectDina Saleh: An HLA ReflectionThis episode of The Ripple Effect features an interview with Dina Saleh, a member of the first London cohort of HLA scholars. The discussion explores Dina's motivations for joining The HLA as a medical student interested in leadership, her positive experiences within the programme, the lasting friendships she formed, and her subsequent career path in clinical oncology. The conversation also reflects on the early days of The HLA, the evolution of its mentoring programme, and the enduring impact of initiatives like LinkedIn articles. Overall, the podcast offers insights into the personal and professional benefits of The HLA experience through...
2025-03-0655 min
Journal of Clinical Oncology (JCO) PodcastJCO Article Insights: HLA-Mismatched Unrelated Donor HCT With PTCy In this JCO Article Insights episode, Alexandra Rojek provides a summary on "Post-Transplant Cyclophosphamide–Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors" by Schaffer et al published in the Journal of Clinical Oncology July 17th, 2024. TRANSCRIPT Alexandra Rojek: Hello and welcome to JCO Article Insights. I'm your host, Alexandra Rojek, and today we will be discussing an original report published in the October 1st issue of JCO titled, "Post-Transplant Cyclophosphamide–Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors," by Shaf...
2024-10-2809 min
Radio NUG for Myanmar Spring" Interview With Union Minister Nor Susanna Hla Hla Soe About The Ministry Of Women's Youth And Children's Assistance To The Ground" ( Interview) Min Thi Han📌 "Interview with Union Minister Nor Susanna Hla Hla Soe about the Ministry of Women's Youth and Children's Assistance to the ground" (Interview) Min Thi Han.This item has files of the following types: Metadata, VBR MP3
2024-09-2600 minCoffee & CompatibilityThe Vital Role of HLA Laboratories in Transfusion SupportHLA Director and Transfusion Medicine Specialist, Dr. Ryan Pena, joins Coffee & Compatibility to discuss how HLA laboratories can support transfusion medicine specialists. From HLA typing to anti-HLA antibody analysis in this niche service, Dr. Pena breaks it all down.
2024-09-2341 min
OncotargetDisrupting NKG2A:HLA-E Interactions for Enhanced Anti-Cancer ImmunityBUFFALO, NY- August 21, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity.”
Two studies using CRISPR screens in cancer cells identified HLA-E as a critical negative regulator of NK cell interactions with cancer cells. Consistent with this, IFNγ signaling was associated with NK cell resistance due to increased STAT1 activation and enhanced HLA-E expression. This effect is also evident in the murine homolog of HLA-E, Qa-1b, which was upregulated by inflammatory signals across all cell types tested.
In addition to inflammatory signals, researchers Jack G. Fisher, Lara V...
2024-08-2102 min
The Synthesis of Wellness®133. HLA Gene Variants & Their Impact on the Immune Response: Specific Gene Variants Associated with Chronic Lyme & Other Conditions, HLA Gene Testing, & MoreIn this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can lend insight when it comes to taking a bioindividual approach to supporting the immune system.
Topics:
2024-08-0222 minCoffee & CompatibilityMolecular testing in HLA and beyond
Dr. Zahra Kashi and Russell Martin share how Kashi Laboratory developed their HLA molecular testing menu and how they expanded into non-HLA molecular diagnostics. Tune in to find out what non-HLA molecular diagnostic testing may be the future for HLA laboratories.
2024-07-2241 min
Fast ForwardMeasure HLA: Is this LA's mobility inflection point?On this episode of the Fast Forward podcast by CoMotion, John Rossant is joined by Michael Schneider, CEO & Founder of Streets For All, the organization behind the recently passed Measure HLA in Los Angeles. Measure HLA requires Los Angeles to add more than 230 miles of bike lanes and 300 miles of bus improvements - but can the car capital of the country really change? Listen for a discussion on the lessons of HLA's success, what the future holds for Los Angeles, and how other cities can adapt the Streets for All playbook.
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Join us next at CoMotion MIAMI '24, May 6-7. Save 50% off on your pas...
2024-03-1523 min
GETECCU PodcastPapel del HLA en Enfermedad Inflamatoria IntestinalLos antígenos leucocitarios humanos (HLA, por sus siglas en inglés) poseen un papel importante en la individualización del tratamiento en Enfermedad Inflamatoria Intestinal. Son biomarcadores del pronóstico de la enfermedad que contribuyen a mejorar la medicina de precisión. En concreto, el HLA es el primer factor que se ha relacionado con el potencial fracaso de un tratamiento. Por ello, es relevante explotar su potencial utilidad.¿Cuál es la situación actual, en cuanto a marcadores se refiere, en la individualización del tratamiento en la Enfermedad Inflamatoria Intestinal? ¿Por qué el HLA se consider...
2024-03-0115 min
Výuka AJ onlineNejlepší hlášky ze seriálu Friends! I Learn English Vocabulary with FriendsOdkaz na video s prezentací: https://youtu.be/EY7AJhqTQFIMáte rádi seriál Přátelé a chcete se při sledování smát nejen vtipům, ale i rozumět anglickým hláškám? Nebo hledáte zábavný způsob, jak se učit anglicky? Pak je dnešní video přímo pro vás! Ponoříme se do světa oblíbeného seriálu Přátelé a prozkoumáme nejlepší hlášky, které nám pomohou nejen zlepšit naši angličtinu, ale také pochopit humor a kulturu, které seriál přináší. 💪🏻Od Ro...
2024-02-0217 min
Black Blood HealsHow HLA Typing is Used to Identify a Stem Cell MatchWelcome back to Black Blood Heals by Be The Match. This week, your host Tamara Weston is joined by Stephanie Lerach, senior immunogenic specialist at Be The Match. Stephanie and her team work with Be The Match to help transplant centers find the best matches for searching patients. You’re going to want to get a pen and paper ready because this episode is going to dive into the technicalities of HLA typing, how our genes and proteins work, and how Be The Match actually finds donor matches for patients. HLA testing is complex and around 70% of pat...
2023-06-1540 min
Warfighter PodcastEp. 015: The Thing About HLA - Björn MöllerContinuing our Education series we are very pleased to Welcome Björn Möller who, whilst serving as the President of Pitch Technologies, is also one of the leading authorities in distributed simulation standards. Bjorn has been deeply involved in shaping the HLA simulation standard for the past 30 years.Bjorn expertly breaks down what can be a complex subject into easily understandable concepts, during this fireside chat. From his lake cabin in Sweden. We hope you’re sitting comfortably.We cover some of the history behind the development of the HLA standard, and what it sets...
2023-04-0727 min
HLA ListenMaster the MRCS Podcast: Colorectal Surgery Part 2In this episode, Sharmaine will cover lower gastrointestinal (GI) conditions tailored to MRCS revision. Content is helpfully broken down into subcategories that aid in making them more comprehendible and easily remembered! - this is the second part in a two-part series
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2022-08-2533 min
HLA ListenMaster the MRCS Podcast: Colorectal Surgery Part 1In this episode, Sharmaine will cover lower gastrointestinal (GI) conditions tailored to MRCS revision. Content is helpfully broken down into subcategories that aid in making them more comprehendible and easily remembered! This is part one of a two-part series.
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2022-08-1834 min
HLA ListenMaster the MRCS Podcast: Upper GI Surgery Part 2In this episode, Sharmaine will cover upper gastrointestinal (GI) conditions tailored to MRCS revision. Content is helpfully broken down into subcategories that aid in making them more comprehendible and easily remembered! This is part two of a two-part series.
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2022-08-1120 min
HLA ListenMaster the MRCS Podcast: Upper GI Surgery Part 1In this episode, Sharmaine will cover upper gastrointestinal (GI) conditions tailored to MRCS revision. Content is helpfully broken down into subcategories that aid in making them more comprehendible and easily remembered! This is part one of a two-part series.
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Send in a voice message: https://podcasters.spotify.com/pod/show/hla-listen/message
2022-08-0417 min
HLA ListenMore Than Episode 4 with Dr Amz ChoudhuryIn our final episode of this HLA mini-series we meet Dr. Amz Choudhury, an NHS Entrepreneur, co-founder and host of his very own podcast the "ScrubbedIn" podcast and co-founder of the revolutionary learning platform "Peer". Check out Dr. Amz's projects @scrubbedin_ and @peerr.io. Dr Choudhury designed and built the Peer education platform. Find out who he is and how he intends to change the world very soon! Dream big and then bigger!
This Podcast is sponsored by Medics.Academy
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2022-06-2325 min
HLA ListenMore Than Episode 3 with Dr Sultan HatabThis week we have the pleasure of hosting a guest who has given talks all around the country. Dr. Sultan Hatab is a psychiatry foundation fellowship doctor who founded his own organisation the "Aafiyah project" which aims to draw focus on maintaining the wellbeing of the mind and soul. In this episode we learn about the challenges he faced and how he overcame them.
Check out Dr. Hatab's project @aafiyahproject
This podcast is kindly sponsored by Medics.Academy
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2022-06-1631 min
HLA ListenMore Than Episode 2 with Allan and HenryIn this weeks episode we meet final year medical student Allan and second year medical student and qualified optometrist Henry. These 2 medical students have founded the @morethanamedic Instagram page. Their goal is aspire to inspire the future generation of medics in any and every way that they can. In this episode we will find out what they do outside of medical school, what their motivations are and their tips for successfully achieving your goals and dreams.
This podcast is kindly sponsored by Medics.Academy
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2022-06-0923 min
HLA ListenMore Than Episode 1 with Dr Aqil JaigirdarThe first episode in the 'More Than' podcast series with Dr Omar Abdul Jolil. Within this podcast, Omar discusses with various individuals who have proven that they are more than just clinicians on what their passions are and how they realised them.Our speaker for this week founded his own charity whilst in medical school, has set up clinics and released educational material across the globe and secured the support of the Royal College of Obstetrics and Gynaecology. In this episode we speak to Dr. Aqil Jaigirdar. We learn what he is currently working on and what steps he...
2022-06-0231 min
ah nah"Susannah Hla Hla Soe" Suzanne and Ruth are joined by Susanna Hla Hla Soe, the National Unity Government's Minister for Women, Youth and Children. A former student activist during the 1988 uprising, she has dedicated much of her career to advocating for the rights of women and children in Myanmar. She was elected minister for Karen ethnic affairs of Yangon in the 2020 general election, but was unable to assume her seat due to the coup in February 2021. She previously served as a member of Parliament of Myanmar from 2015-2020. Susanna has publicly apologised to ethnic minorities, including the Rohingya community, for her failure to...
2022-02-2732 min
Holobiont#15 Atypical T cell responses: HLA-E Immunology (Sir Andrew McMichael)Sir Andrew McMichael is a Professor of Immunology at the University of Oxford and previously Director of the Weatherall Institute of Molecular Medicine. He is a fellow of the Royal Society and Academy of Medical Sciences and has been a leader in human immunology for decades, notably focusing on responses to viral infections including influenza and HIV.
We discuss:
Prof McMichael's career in immunology spanning from his work in the 1980s on HLA restriction and recognition of viral peptides to the study of a HLA-E, an atypical MHC-Ib molecule that is involved in immunosurveillance
How HLA-E is...
2021-11-2550 min
HLA ListenEpimedic: Crime and chanceThis episode will cover the concept of chance in statistics using the example of DNA evidence in criminal courts.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North East and Health Education England South West. The HLA partners with Medics.Academy and through Medics.Academy its programme is accredited by the Medical School at the University of Central Lancashire. The HLA is also supported by University College London’s Academic Careers Office.
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2021-07-3108 min
HLA ListenEpimedic: Political polling and bias2016 was an important year for politics. Two world-changing events happened: EU referendum (or Brexit) and the US presidential election. The results of both events came as a surprise to nearly everyone who had been following the opinion polling closely. It is believed that selection bias played a role in influencing the results. This episode will cover the concept of bias in statistics.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North East and Health Education England South West. The HLA...
2021-07-2407 min
HLA ListenEpimedic:The weekend effect and confounding factorsOn 12 January 2016, junior doctors took part in a general strike across the NHS in England for the first time since 1975. At the centre of the dispute was the weekend effect. The ex-health secretary, Jeremy Hunt, had repeatedly use this effect to back his push for 24/7 NHS and the new junior doctor contract in 2016. This episode will explore the concept of weekend effect and how its research is complicated by confounding factors.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North...
2021-07-1708 min
HLA ListenEpimedic:To test or not to testTesting for covid-19 comes with many benefits, but no test is 100% sensitive and specific. This episode will explain the concept of sensitivity and specificity using the example of covid-19 testing.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North East and Health Education England South West. The HLA partners with Medics.Academy and through Medics.Academy its programme is accredited by the Medical School at the University of Central Lancashire. The HLA is also supported by University College London’s Ac...
2021-07-1008 min
HLA ListenEpimedic: The process of vaccine developmentThis episode focuses on the process of drug development using the example of the Covid 19 vaccine. It will also provide the listeners with a walkthrough of the phase 3 trial of the Pfizer-BioNTech vaccine. The study type of randomised controlled trials will be briefly explored.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North East and Health Education England South West. The HLA partners with Medics.Academy and through Medics.Academy its programme is accredited by the Medical School at the...
2021-07-0309 min
HLA ListenEpimedic: Epidemiology 101This episode will introduce the listeners to the study of Epidemiology. Epidemiology is the study of distribution (including frequency and pattern), risk/ protective factors and interventions (including diagnosing and management) of diseases. 3 historical stories (Dr John Snow and cholera, Dr Percival Pott and scrotal cancer and Dr James Lind and scurvy) will be used to further explained the study areas.
The HLA is approved by The Institute of Leadership & Management, is a certified member of Social Enterprises UK, and is commissioned by Health Education England North East and Health Education England South West. The HLA partners with...
2021-06-2709 min
HLA ListenThe Critical Care Podcast - Building the right foundation:: Neurological assessments and management of sedation and pain relief medicationJoin Raluca (ICU Nurse) and Chris (ICU Consultant) in looking after Mary, a (hypothetical) patient who has been in ICU for a week following a cardiac arrest.
We are looking at reducing sedation and assessing Mary’s neurology. Join us in discussion:
Sedation? What is this and what medications we may use?
Pain relief: what and why?
How to assess neurology: GCS, RASS and CAM-ICU
Delirium and its management.
We mention research around GCS:
Glasgow Coma Scale: Teasdale, G. and Jennett, B. (1974) 'Assessment of coma and impaired consciousness’, The Lancet, 2 (7872), pp.81...
2021-06-1953 min
HLA ListenHow is government influenced on Obesity Policy? | Dolly Theis | Healthy Discussions #6Dolly Theis is not your usual public health policy academic. She stood as a Conservative Party candidate in the 2017 general election, winning 10,000 votes in Vauxhall. As a One-Nation Tory, Dolly has also campaigned on environmental and food issues. She has also been involved with initiatives like 50:50 Parliament (for gender balance in Westminster) and the veteran's charity Forward Assist.
She is undertaking a PhD at Cambridge University’s MRC Epidemiology Unit, researching how policy makers use evidence and the processes that influence change in public health.
In this conversation, Zack and Dolly find points of agreement on...
2021-06-1543 min
HLA ListenThe Critical Care Podcast - Building the right foundation : Renal failure and Renal Replacement TherapyBianca, our hypothetical patient, gets admitted from the ward with severe diarrhoea and a potassium of 7.5.
Join Raluca (ICU Nurse) and Chris (ICU Consultant) in discussing:
What is “renal failure”
How to prepare for this admission
Treatment options for Bianca
Renal Replacement theory: the principles
Don’t miss our three takeaway messages and please send us yours!
Enjoy the episode!
Raluca Vagner- Intensive Care Nurse @RalucaVagner
Chris Gough- Intensive Care Consultant @GoughCJ
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2021-06-1239 min
HLA ListenThe Critical Care Podcast - Building the right foundation: Hypovolemic shockCara (our hypothetical patient) develops hypovolaemic shock following a laparotomy.
Join Raluca (ICU Nurse) and Chris (ICU Consultant) in a discussion about:
What do we want to know from the handover?
What is the management of hypovolaemic shock?
Blood product and their importance
Major Haemorrhage protocol
My (Raluca) lightbulb moment: Hb may not always drop enough to indicate a bleeding – find out why!
Don’t miss our three takeaway messages and please send us yours!
Enjoy the episode!
Raluca Vagner- Intensive Care Nurse @RalucaVagner
Ch...
2021-06-0541 min
HLA ListenMaking Change in the NHS | Professor Partha Kar OBE | Healthy Discussions #5Professor Partha Kar OBE is a Consultant Endocrinologist in Portsmouth, the National Specialty Advisor to NHS England for Diabetes and Obesity, and the National Associate Clinical Director for Diabetes. He is well recognised by the Type 1 Diabetes community for projects such as TAD talks (Talking about Diabetes), improving access to non-invasive Libre sensors, and his social media presence. He has also co-founded other initiatives such as the Super Six model for diabetes care, Language Matters with NHS improvement to change the language clinicians use with patients, and Getting it Right First Time.
In this conversation, Partha and...
2021-05-3057 min
HLA ListenThe Critical Care Podcast - Building the right foundation: Septic shockJoin Raluca (ICU Nurse) and Chris (ICU Consultant) in admitting and looking after our hypothetical patient Vincent who has presented to hospital in septic shock.
We will talk about:
Types of shock
How to prepare for this admission
How to manage a patient with septic shock
Use of vasoactive medication
Literature and research mentioned in the podcast:
Sepsis Guidelines: https://sepsistrust.org/
And much more. Give away – the patient always gets better!
Don’t miss our three takeaway messages and please send us yours!
Enjo...
2021-05-2946 min
HLA ListenThe Critical Care Podcast - Building the right foundation : Covid through the eyes of a nurse, a physio, and a doctorThis is a special episode where Raluca (ICU Nurse) is joined by Chris Gough, Intensive Care Consultant and Owen Gustafson, Intensive Care Physiotherapist.
We all talk about our experiences of going through a pandemic and the different challenges and successes we’ve encountered.
This is a fun conversation, but also a hard one. We share our worries, stresses, concerns and hoped for the future.
We leave you on a positive note, with food for thought: what three things would you change/implement/continue in your area of practice that can make the NHS th...
2021-05-221h 12Journal of Clinical Oncology (JCO) PodcastA Deep Dive Into HLA Typing For Unrelated Donor Hematopoietic Cell TransplantationThis podcast comments on a large registry study evaluating the effect of ultra-high-resolution HLA typing on outcomes of unrelated donor transplantation. TRANSCRIPT This JCO Podcast provides observations and commentary on the JCO article 'Impact of Previously Unrecognized HLA Mismatches Using Ultra-High-Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation" by Mayor et al. My name is Navneet Majhail, and I am the Director of the Blood and Marrow Transplant Program and the Vice-Chair for the Department of Hematology and Medical Oncology at the Taussig Cancer Institute, Cleveland Clinic. My oncologic specialty is transplantation and...
2021-05-2009 min
HLA ListenToo Little, Too Late for Mental Health | Dr Lade Smith CBE | Healthy Discussions #4Dr Lade Smith CBE is Director of Forensic Services at South London and Maudsley Foundation Trust and 2019's Psychiatrist of the Year. Her background as an intensive care forensic psychiatrist has given her insight into the stories of family psychological trauma that are prevalent amongst the UK's violent offenders. She is also an advocate for race equality and has published research examining racial disaprities in the use of detention orders under the Mental Health Act. Zack and Lade discussed how criminality and mental illness can be traced back to adverse childhood experiences, the need for early intervention, and the...
2021-05-1642 min
HLA ListenThe Critical Care Podcast - Building the right foundation: Intubation and ventilationWe are following Robert’s continuous deterioration which leads to him being intubated. Join Raluca (ICU Nurse) and Chris (ICU consultant) to discuss more:
When do we intubate?
Is intubation risky?
Overall principles of a ventilator (main modes and settings)
Doctors and nurses working together in intubating a patient
Weaning off the intubation
“failed extubation” or is it really a failure?
Literature and research discussed:
Difficult Airway Society: https://das.uk.com/guidelines/icu_guidelines2017
Ventilation strategies: https://litfl.com/ardsnet-ventilation-strategy/
Human Factors: https://litfl.com/lessons-from-the-bromiley-case/
Don’...
2021-05-151h 13
HLA ListenThe Critical Care Podcast - Building the right foundation: Respiratory Failure and Non-Invasive VentilationIn this episode, Raluca (ICU Nurse) will be talking to Chris (ICU consultant) about a hypothetical patient called Robert who was admitted with an exacerbation of COPD.
Join us to find out more about:
-Type 1 and Type 2 Respiratory Failure
-What to get ready at your bedspace for this admission
-What you may want to get from the handover
-Escalation of treatment
-Use of Non-Invasive Ventilations
Research mentioned:
British Thoracic Society: https://www.brit-thoracic.org.uk/
NICE: https://pathways.nice.org.uk/pathways/chronic-obstructive-pulmonary-disease...
2021-05-0846 min
HLA ListenHealth Inequalities & Covid-19 | Dr Carey Lunan | Healthy Discussions #3Carey Lunan is a GP in Craigmillar, Edinburgh and Chair of the DeepEnd Group, made up of the 100 GP practices in Scotland's most deprived areas. She has also been chair of the Royal College of GPs in Scotland, leading on reports to government and policy, and representing the profession in mainstream media. She has a long-standing interest in health inequality and is a familiary contributor to public discourse concerning health issues in Scotland.
In this conversation, Carey and Zack discuss a range of ideas, including what's different about medicine in deprived populations, the trade-off between access and...
2021-05-041h 05
HLA ListenEpisode 6: Decolonising the Medical Curriculum with Sarah Wong and Tina PlowmanSarah Wong and Tina Plowman are two medical students who have been involved with organising the decolonising the medical curriculum movement at UCL. Last year they set up a facebook group, using the platform to organise regular discussions and roundtable talks, alongside students from other medical schools, discussing topics around racism, health inequalities and concepts around decolonisation in healthcare. In this episode they talk more about the work they are involved in, the purpose of the decolonising movement and put forward some solutions on ways to improve the medical curriculum today.
Twitter: @decolonisingmed
Fa...
2021-05-0240 min
HLA ListenEpisode 5: Mental Health of Students during COVID with Shantanu Kundu"Shantanu Kundu is a medical student at the University of Liverpool and founder of the Be Free Campaign, a charity that works across the country delivering workshops and holding street campaigns in the hope to demolish the stigma behind mental health. His organisation also works with Youtubers and influencers to promote positive mental health via their audience. Shantanu’s services to charity and commitment to helping the lives of others, resulted in him receiving the Diana awards in 2020, the highest accolade a young person can achieve for humanitarian effort and social action.
In this epi...
2021-04-2535 min
HLA ListenBinge Eating & Digital Health | Richie Cartwright | Healthy Discussions #2Richie Cartwright is Co-founder at Fella, a global community-driven digital health platform to guide men through Cognitive Behavioural Therapy for Binge Eating. He founded and sold the company Flow X, which worked with the UK government on improving traffic flow using artificial intelligence. An avid entrepreneur and economics graduate from Cambridge, he is determined to share his own story of struggling with binge eating to help the millions of other people who have it too, both men and women.
In this conversation, Richie and Zack discuss how to look after our mental health from day to day...
2021-04-2041 min
HLA ListenEpisode 4: Barriers to health in the deaf community with Rebecca LennoxRebecca Lennox is a second year nursing student at John Moores University and alumni of the #150 Leaders Student Programme. Believing there was a huge gap in the care and treatment of people from the Deaf community, Rebecca and her colleague introduced British Sign Language classes for university staff and students, enlisting the help of a charity called Deaf Active. Demand for places were so high that now Rebecca is pushing for Sign Language classes to be on the curriculum for all nursing students. In this episode, she talks more about her campaign and the importance of learning British Sign L...
2021-04-1837 min
HLA ListenEpisode 3: Widening participation in Medicine with James FraterJames Frater is the co-founder of a social enterprise the Ladder Project, and the African and Caribbean Student Lead of King’s College London Widening participation programme. He is also part of Imperial's inaugural Black Students Advisory Panel and sits on the Youth Advisory Council for the Foundation for Education Development. To top it all off he is recognised as being one of the most outstanding students in the UK by Future Leaders, Rare Recruitment and The Association of Jamaican Nationals. And this is all while still being a medical student at Kings College London University. In this episode, we d...
2021-04-1146 min
HLA ListenEpisode 2 : The Future of Drones in Healthcare with Hammad JeilaniHammad Jeilani is the director and co-founder of a company called Apian, a healthcare startup that is using drones to improve access to healthcare in a faster and environmentally friendly manner. Hammad is also a NHS clinical entrepreneur, a programme run by NHS England aimed to develop the next generation of leaders to help transform our healthcare system. And on the side he is also a medical student at Barts and The London School of Medicine and Dentistry. In this episode we discuss Hammad's journey in setting up Apian, the potential that drones have in transforming healthcare delivery and i...
2021-04-0449 min
HLA ListenImproving Healthcare Awareness with Rafia MiahRafia Miah is a final year medical student at the University of Southampton. She has been involved in numerous organisations and last year received a scholarship to be a part of the Healthcare Leadership Academy. Passionate about women’s health she has recently set up an organisation called Amar Doctor, meaning my doctor, an initiative specifically targeted towards Bengali women in the UK which aims to provide educational seminars on a variety of different health-related topics.
In this episode, we discuss why Bangladeshi women historically have the poorest health outcomes in the UK and strategies to address th...
2021-03-2834 min
HLA ListenDoctors in Politics | Dr Philippa Whitford MP | Healthy Discussions #1Born in Belfast, Dr Philippa Whitford studied medicine in the West of Scotland before specialising in breast surgery. She has been a Consultant Breast Surgeon for 19 years, and is now the MP for Central Ayrshire and the Westminster spokesperson on Health and Europe for the Scottish National Party. Over her career she has studied Breast Cancer Immunology for her MD dissertation, worked as a medical volunteer in Palestine and sat on the Health Select committee.
In this inspiring conversation, Philippa and Zack discuss the misogyny she experienced as a young surgeon in the 1980s, the advantages of...
2021-03-011h 15
PharmaTalkRadioHLA Loss and the Impact on ImmunotherapyLoss of the HLA locus impairs presentation of tumor antigens and is frequently found in advanced cancers. This talk presented by Dr Lee Albacker, Foundation Medicine and first recorded at the 2020 IO360° Summit, will describe the landscape of HLA loss and other response biomarkers in a dataset of 90,000 solid tumor samples and highlight the effect of HLA loss on checkpoint inhibitor response. To learn more about the upcoming IO360° 2021 Summit please visit www.io360summit.com
2020-12-2721 min
HLA ListenThe Guide to Global Health: The Role of personalityIn this episode of the Guide to Global Health, Pedra Rabiee discusses the personal attributes that can either be advantageous or a barrier in working in global health with Dr. Mishal Khan.
Dr. Khan is an Associate Professor of Health Policy and Systems Research at the London School of Hygiene & Tropical Medicine. Her expertise is in quantitative and qualitative health policy and systems that focuses on improving infectious disease control programmes in South and Southeast Asia. She is also an Associate Fellow at the Centre on Global Health Security at Chatham House, working closely with high level policy actors on...
2020-09-0722 min
HLA ListenThe Guide to Global Health: Academia with Eduardo Gómez In this episode of the Guide to Global HealtPedra Rabiee discusses what it is like to be an academic in global health with Dr. Eduardo Gómez. Dr. Eduardo J. Gómez as an Associate Professor in the College of Health at Lehigh University. A political scientist by training, Dr. Gómez’s research focuses on the politics of global health policy, with a focus on the emerging economies. He has published a myriad of scholarly and media articles and is the author of three books. His most recent book, Geopolitics in Health, was published by Johns Hopkins University press in 2018. Dr. Gómez has held prior academic appointmen...
2020-08-3137 min
HLA ListenThe Guide to Global Health: Gender Equity with Jackie CorleyIn this episode of the Guide to Global Health, we will discuss Jackie Corley’s work through the Gender Equity in Global Surgery Initiative. Jackie is a neurosurgery resident physician at Duke and a current research fellow at the Program in Global Surgery and Social Change at Harvard Medical School. She focuses on global neurosurgery research and global health advocacy and policy to promote health systems strengthening. Jackie is also a founder and co-president of the Gender Equity Initiative in Global Surgery, which strives to promote gender equity in the surgical, anaesthesia, and obstetric workforce around the world though dire...
2020-08-2424 min
HLA ListenThe Guide to Global Health: Patient Safety with Dr Ahmed AlboksmatyIn this episode of the Guide to Global Health, we will discuss Ahmed Alboksmaty’s journey from Egypt to the UK as a public health practitioner. Ahmed Alboksmaty is a medical doctor and a research associate in the NIHR Patient Safety Translational Research Centre at Imperial College London. He has previously worked as a consultant in quality and patient safety for the WHO EMRO and earlier as a Medical Coordinator for a joint project between UNHCR and the Arab Medical Union. In addition, he has been granted some regional and international awards for youth leadership and entrepreneurship in public he...
2020-08-1720 min
Podcast Sonho BemVindo#10 KIR HLA-C. Imunologia da Implantação. Dra Natalia GonçalvesO décimo episódio do Podcast Sonho BemVindo é sobre KIR HLA-C, que é um exame específico para avaliar a complexa relação imunológica entre embrião e o útero. Apesar do tema parecer muito específico, os casais que têm abortamentos de repetição e falhas de implantação após várias transferências de embrião, podem encontrar neste exame um desfecho. No bate-papo falamos sobre a história das células NK, a diferença entre as uterinas e as periféricas, o conceito do que é o KIR, como é feito esse exame, sua logística e fluxograma clí...
2020-08-111h 12
HLA ListenThe Leader as a ScholarThis final episode of the series focuses on Scholarship. Tinaye Nandi and Med explore the importance of evidence-based leadership and management. We use the story of Ignes Semmelweis to explain the importance of evidence and that good scholarship means ensuring that those you want to learn are encouraged to access information.
The podcast is found here
https://thehealthcareleadership.academy/podcasts/
The leadernotes here
https://thehealthcareleadership.academy/the-leadership-blog/
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2020-07-0710 min
HLA ListenThe Leader as a FollowerIn today's episode, we focus on leadership's underappreciated cousin Followership. We talk about Activist Bayard Rustin and the importance of followership, in the development of a great leader, his mentee Martin Luther King Junior. We talk about the theory of Leader-follower relationships and how you can be the best type of follower.
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2020-06-3013 min
HLA ListenThe Leader as An InnovaterIn the weeks' episode, we focussed on learning to innovate from scratch, and how to apply these skills to already existing organisations and products so that you can try this there too. We discussed how Da Vinci worked as a constant innovator and ways to think about innovating a new idea for yourselves, We also talked about Thomas Eddison's employment of different types of innovation and what those types are.
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2020-06-2312 min
HLA ListenLeader as a CommunicatorWe spoke about communication in this episode. Highlighting businesses which have really benefited from open communication methods. We talked through the 7 C’s of communication and spent some time reflecting on the ways we best receive information.
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2020-06-1611 min
HLA ListenLeader as a TeambuilderIn this episode we talk about team building ; touching on Prof Meredith Belbin’s 9 characteristics for team building. We close out the episode with Nandis' interview of the eminent Dr R Pickering.
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2020-06-0930 min
HLA ListenLeader as treasurerIn this episode, we focused on the skills you need to be a good treasurer. We started by talking about business models and the business model canvas, we considered the downfall of the infamous Woolworths, and we thought about the principle of decentralisation.
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2020-06-0214 min
HLA ListenWomen in Healthcare Leadership #BonusIn this special episode, Tinaye Mapako interviews Dr Carina Dowson Project Co-ordinator for women in Healthcare Leadership (WIHL) at the HLA. We talk about Leadership, getting more women involved in leadership, Who inspires her and why leadership is important for all doctors.
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2020-05-2614 min
HLA ListenThe Leader as a PlannerIn this episode, we focused on the skills you need to be a good planner. We started by talking about turning visionary leadership into a tangible strategy. We considered the power that planning gave Shaka Zulu and the Zulu empire, adding him to our leadership wall of fame. We thought about the Pareto principle and how it relates to task completion and considered the use of Gantt charts.
To build a leader is a weekly podcast brought to you By Ahmad Elmansouri, Nandi Mnyama and Tinaye Mapako leadership scholars at HLA Listen. You can find HLA listen...
2020-05-1913 min
HLA ListenThe Leader as a NegotatiorIn our first episode, we focus on the skills you need to be a good negotiator. We talk about the people you need in the room; the lessons we could learn from ex-PM Tony Blair negotiation of the Good Friday agreement, and lastly, we will talk about different tactics we can use in the room.
To build a leader is a weekly podcast brought to you By Ahmad Elmansouri, Nandi Mnyama and Tinaye Mapako leadership scholars at HLA Listen. You can find HLA listen to podcasts on all good podcasting apps and on our website https://thehealthcareleadership.a...
2020-05-1215 min
HLA ListenTo Build A leader PromoTo Build A leader is a weekly podcast all about nurturing leadership skills join Med, Nandi and Tinaye as they break down leadership with cutting edge research, interviews and lots of fun too.
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2020-04-2400 min
Kermode on Film#77: MK3D Live! 50th Show Part 2 with Amma Asante, David Arnold and Jason Isaacs#77: MK3D Live! 50th Show Part 2 with Amma Asante, David Arnold and Jason IsaacsMark and guests feature in the second half of a special 50th live MK3D show from the BFI Southbank.Follow Mark @KermodeMoviewww.markkermode.co.ukKermode On Film is produced by HLA Agency and Hidden FlackProducers Hedda Archbold, Nick Freand Jones and Tom Whalley© HLA Agency Hosted on Acast. See acast.com/privacy for more information.
2020-03-2454 min
Kermode on Film#76: MK3D Live! 50th Show with Sanjeev Bhaskar and Neil Brand#76: MK3D Live! 50th Show with Sanjeev Bhaskar and Neil BrandMark and guests feature in the first half of a special 50th live MK3D show from the BFI Southbank.Follow Mark @KermodeMoviewww.markkermode.co.ukKermode On Film is produced by HLA Agency and Hidden FlackProducers Hedda Archbold, Nick Freand Jones and Tom Whalley© HLA Agency Hosted on Acast. See acast.com/privacy for more information.
2020-03-1743 min
Kermode on Film#74: Star Wars Special - Mark and Jack Howard rank the Star Wars films from worst to bestMark and Jack Howard rank the Star Wars films from worst to best.Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F31E26A-0485-48B9-B9CB-4BA957BE7942If it says it...
2020-03-0339 min
Kermode on Film#73: MK3D Live! with Kerry Fox, James Norton and director J P Valkeapää#73: MK3D Live! with Kerry Fox talking about her new film 'Little Joe', James Norton on 'Mr Jones' and 'The Trial Of Christine Keeler' plus director J P Valkeapää on his extraordinary feature 'Dogs Don't Wear Pants' plus the top ten plants in movies!Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9...
2020-02-251h 18
Kermode on Film#72: British Film Designer's Guild Awards SpecialBritish Film Designer's Guild Awards SpecialMark talks to some of the nominees and winners from the British Film Designer's Guild Awards held a few weeks ago in London.Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F3...
2020-02-1858 min
Kermode on Film#71: MK3D Live! with Kristin Scott Thomas and Armando IannucciMK3D Live! with guests Kristin Scott Thomas, Armando Iannucci, Alfred George Bailey and Jack Howard.Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F31E26A-0485-48B9-B9CB-4BA957BE7942If...
2020-02-141h 18
Kermode on Film#69: The Kermode Awards 2020 - Mark picks his winners from the films ignored by the AcademyThe Kermode Awards 2020 - Mark picks his winners from the films ignored by the Academy. Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F31E26A-0485-48B9-B9CB-4BA957BE7942If it...
2020-02-0420 min
Kermode on Film#68: Live From the Rotterdam Film Festival - Mark and Jack Howard talk Star Wars, Film Music and ask what's the point of film critics?Live From the Rotterdam Film Festival - Mark and Jack Howard talk Star Wars, film music and ask what's the point of film critics?Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F31E26A-0485-48B9-B9CB-4BA...
2020-01-281h 15
Kermode on Film#66: MK3D Live! with Dexter Fletcher and Maxine PeakeMK3D Live! Mark talks to Dexter Fletcher on his hit musical biopic of Elton John - Rocketman and to actress Maxine Peake on her acting career and the film that changed her lifeWant to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::lo...
2020-01-1342 min
Kermode on Film#62: MK3D Live! with Taron Egerton, Emily Beecham and Gwenno SaundersMK3D Live! with Taron Egerton talking about his barnstorming performance in 'Rocketman' , Emily Beecham on the forthcoming Cannes hit 'Little Joe' and and musician Gwenno Saunders about working with Mark Jenkin on 'Bait'.Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::lo...
2019-12-191h 11
Kermode on Film#60: Mark and Jack Howard go head to head on the Terminator franchiseMark and Jack Howard go head to head on the long running and wildly variable Terminator franchise.Want to come to a recording of a Mark Kermode Live in 3D show at the BFI Southbank in London?You can book tickets to next month’s MK3D here:https://whatson.bfi.org.uk/Online/default.asp?doWork::WScontent::loadArticle=Load&BOparam::WScontent::loadArticle::article_id=9FD162DC-3C10-43AB-ADCC-31364C1822AE&BOparam::WScontent::loadArticle::context_id=9F31E26A-0485-48B9-B9CB-4BA957BE7942...
2019-12-1042 min
KviziŠportni kviz: Anja Hlača Ferjančič in Marko CirmanPoletni kvizi Vala 202 so namenjeni zabavi, igranju in širjenju obzorij. Idealni za poslušanje med vožnjo na morje, odlični za sproščanje med čakanjem na mejnem prehodu in primerni za kratkočasenje v koloni.
Poslušate lahko deset epizod kvizov Nimam pojma, Antikviza, Športnega kviza in Kviza o zanimivostih, povezanih z Valom 202.
Z vami so Miha Šalehar in Andrej Karoli, Tadej Košmrlj in Uršula Zaletelj, Anja Hlača Ferjančič in Marko Cirman, Luka Petrič s kolegi reporterji ter Aleš Smrekar in Damjan Zorc.Poletni kvizi so namenjeni zabavi, igranju in širjenju obzorijKvizi so idealni...
2019-06-1613 minKviziŠportni kviz: Anja Hlača Ferjančič in Marko CirmanPoletni kvizi Vala 202 so namenjeni zabavi, igranju in širjenju obzorij. Idealni za poslušanje med vožnjo na morje, odlični za sproščanje med čakanjem na mejnem prehodu in primerni za kratkočasenje v koloni.
Poslušate lahko deset epizod kvizov Nimam pojma, Antikviza, Športnega kviza in Kviza o zanimivostih, povezanih z Valom 202.
Z vami so Miha Šalehar in Andrej Karoli, Tadej Košmrlj in Uršula Zaletelj, Anja Hlača Ferjančič in Marko Cirman, Luka Petrič s kolegi reporterji ter Aleš Smrekar in Damjan Zorc.Poletni kvizi so namenjeni zabavi, igranju in širjenju obzorijKvizi so idealni...
2019-06-1611 min
El RemateEl Remate - 2019.04.15 "Especial HLA Alicante: Los Albertos, Kali Nord, actualidad y resumen del Hércules"Vuelve "El Remate 3.05" a radio San Vicente. A partir de las 20:00 en la 95.2FM; en los dispositivos móviles gracias a la aplicación de la emisora y por Internet en www.radiosanvicente.com.
Hoy dedicaremos gran parte del programa al HLA Alicante con protagonistas muy especiales, no suelen ocupar grandes portadas pero tienen una labor muy importante en el club.
Entrevistaremos a los técnicos ayudantes de Pedro Rivero, conocidos como "Los Albertos": Alberto Antuña y Alberto Carrillo.
Nos visitan Gabi y Ana, miembros de la peña Kali Nord, que nos contarán las iniciativas para los próxim...
2019-04-161h 00
Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 05/07Charakterisierung des HLA-Klasse-I Ligandoms in Primärtumoren beim humanen NierenzellkarzinomT-Zellen können tumorassoziierte HLA-präsentierte Peptide auf Tumorzellen des Nierenzellkarzinoms erkennen, und diese dann eliminieren. Gelingt es, diese Fähigkeit des Immunsystems mit einer Impfung geziehlt anzuregen kann eine Peptid-basierte Immuntherapie ein Verfahren zur Behandlung des Nierenkrebeses darstellen. Aus diesem Grund wurden durch massenspektrometrische Untersuchungen HLA-Klasse-I Ligandome maligner transformierter Zellen des soliden Nierenzellkarzinoms isoliert. Mit Hilfe von vergleichenden Genexpressionsanalysen wurden diejenigen Gene identifiziert, die aufgrund ihres Expressionsmusters als tumorassoziiert angesehen werden können. Diese aus HLA-Liganden abgeleiteten Tumorantigene stellen potentielle T-Zellepitope für eine Peptid-basierte Immuntherapie dar.
2011-02-1200 min
Medizin - Open Access LMU - Teil 16/22High-throughput high-resolution class I HLA genotyping in East Africa.HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria, and tuberculosis, but the HLA genetic diversity in this region remains incompletely described. This is a major obstacle for the design and evaluation of preventive vaccines. Available HLA typing techniques, that provide the 4-digit level resolution needed to interpret immune responses, lack sufficient throughput for large immunoepidemiological studies. Here we present a novel HLA typing assay bridging the gap between high resolution...
2010-01-0100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 10/19Immungenetische Untersuchungen zur Assoziation von Polymorphismen im nicht-klassischen MHC-Klasse-Ib-Gen HLA-G mit der schwangerschaftsinduzierten Autoimmundermatose Pemphigoid gestationisPemphigoid gestationis ist eine seltene blasenbildende Autoimmundermatose unklarer Ätiologie, die ausschließlich im Zusammenhang mit Schwangerschaften oder schwangerschaftsassoziierten Tumoren beobachtet wird. Als Autoantigen konnte das Transmembranprotein Kollagen-Typ-XVII, ein Strukturelement der Hemidesmosomen der dermoepidermalen Junktionszone, identifiziert werden. Der selbstlimitierende Krankheitsverlauf und die hohe Rezidivneigung bei Folgeschwangerschaften deuten auf eine pathogenetische Rolle schwangerschaftsspezifischer Veränderungen endokriner sowie immunologischer Faktoren hin. Es besteht darüber hinaus eine Assoziation mit den MHC-Klasse-II-Antigenen HLA-DR3 und -DR4 bei den Patientinnen sowie mit dem väterlichen Haplotypen HLA-DR2.
HLA-G ist ein nicht-klassisches MHC-Klasse-Ib-Molekül, das hauptsächlich von den extravillösen Trophoblasten der Plazenta exprimiert wird. Es gibt z...
2009-11-1900 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 02/19Therapie der Spondylitis ankylosans mit dem monoklonalen chimären anti-TNF-Antikörper Infliximab (Remicade®):Klinische Wirksamkeit und Einfluss auf die HLA-Oberflächenexpression auf Lymphozyten mit besonderer Berücksichtigung von HLA-B27In der vorliegenden Arbeit wurden therapeutische und immunmodulatorische
Effekte einer TNF-Blockade bei Patienten mit aktiver Spondylitis ankylosans untersucht. Hierzu wurde an 10 Patienten während einer 60wöchigen Infliximabtherapie eine Evaluation von Therapiewirksamkeit und -sicherheit, sowie eine durchflusszytometrische Analyse der HLA-Oberflächenexpression auf Lymphozyten vorgenommen.
Von 8 Patienten wurde die Therapie ohne ernste Nebenwirkungen gut vertragen und führte zur raschen und dauerhaften Verbesserung der klinischen, laborchemischen und radiologischen Verlaufsparameter. Ein Patient entwickelte nach initialer Wirksamkeit ein sekundäres Therapieversagen, bei einem weiteren Patienten wurde die Therapie unter dem Verdacht eines medikamentös induzierten Lupus-Syndroms abgebrochen.
Gegen Mitte des Behandlungszeitraumes konnte ein am deu...
2004-06-2400 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06Expression und immunmodulatorische Funktion von HLA-G und seinen verkürzten Isoformen in TumorzellinienDas nicht polymorphe HLA-Klasse-I-Antigen HLA-G wird hauptsächlich in der Plazenta exprimiert, wo es vermutlich den semiallogenen Fötus vor Angriff des mütterlichen Immunsystems schützt. Eine Besonderheit von HLA-G ist das Auftreten von mehreren verkürzten Isoformen, die von alternativ gespleißten Transkripten translatiert werden. Neben dem kompletten membranständigen HLA-G1 mit den extrazellulären Domänen a1, a2 und a3 existieren die verkürzten Isoformen HLA-G2 (∆a2), HLA-G3 (∆a2, ∆a3) und HLA-G4 (∆a3). Außerdem wurden die löslichen Isoformen HLA-G5 (HLA-G1s), HLA-G6 (HLA-G2s, ∆a2) und HLA-G7 (HLA-G3s, ∆a2, ∆a3) beschrieben.
Um die Expression und Funktion einzelner Iso...
2004-04-2300 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06Das komplexe Expressionsmuster von HLA-G und die Bedeutung seiner Genprodukte für die Funktion Antigenunspezifischer ImmuneffektorzellenIm Unterschied zu den HLA-Klasse-Ia-Molekülen ist das nicht-polymorphe Klasse-Ib-Molekül HLA-G v.a. in der Plazenta exprimiert. Es wird postuliert, daß HLA-G die Immuntoleranz des mütterlichen Immunsystems gegen den „semiallogenen“ Fetus mitreguliert. In allen anderen Zellen und Geweben, in denen es gefunden wurde, ist die Menge im Vergleich zu klassischen Klasse-I-Molekülen um Größenordnungen geringer. Auch in der Genexpression unterscheidet sich HLA-G drastisch von allen übrigen Klasse-I-Molekülen. Am auffallendsten ist dabei das Auftreten verschiedener alternativer Spleißformen. Neben dem Volle-Länge-Transkript G1m gibt es eine Reihe verkürzter Isoformen: G2 (G2m, Da2-Domäne), G3 (Da2/Da3-Domän...
2002-03-0100 min
Biologie - Open Access LMU - Teil 02/02HLA-G: expression in human keratinocytes in vitro and in human skin in vivoClassical, polymorphic major histocompatibility complex class I molecules are
expressed on most nucleated cells.They present peptides at the cell surface and,
thus, enable the immune system to scan peptides for their antigenicity. The
function of the other, nonclassical class I molecules in man is controversial.
HLA-G which has been shown by transfection experiments to be expressed at the
cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a
role of HLA-G in the control of rejection of the allogeneic fetus has been
discussed. We found that HLA-G expression is induced in keratinocytes by
culture...
1994-01-0100 minBiologie - Open Access LMU - Teil 02/02Presence of an expressed 13-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunctionAn expressed beta-tubulin gene (TUBB) has previously
been localized to chromosome region 6pter-p21
in man. By using a panel of deletion mutant cell lines and
radiation-reduced hybrids containing fragments of chromosome
6, the TUBB locus could be mapped to the HLA
class I region at 6p21.3. A long range restriction map including
TUBB and several HLA class I genes was then
generated by rotating field gel electrophoresis. The results
show that TUBB maps to a segment 170-370 kb telomeric
of HLA-C. This location suggests that a mutation at the
TUBB locus could be the cause for certain forms of HLAlinked
microtubule...
1994-01-0100 minBiologie - Open Access LMU - Teil 02/02HLA-J, A SECOND INACTIVATED CLASS I HLA GENE RELATED TO HLA-G AND HLA-AMesser, Gerald; Zemmour, Jaqueline; Orr, Harry T.; Parham, P.; Weiß, Elisabeth und Girdlestone, J. (1992): HLA-J, A SECOND INACTIVATED CLASS I HLA GENE RELATED TO HLA-G AND HLA-A. Implications for the Evolution of the HLA-A-Related Genes1V2. In: Journal of Immunology, Vol. 148: pp. 4043-4053.
1992-01-0100 minBiologie - Open Access LMU - Teil 02/02Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-EThe assembly of the classical, polymorphic major histocompatibility complex class I molecules
in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin
(~2m). Formation of this trimolecular complex is a prerequisite for e~cient transport to the
cell surface, where presented peptides are scanned by T lymphocytes. The function of the other
class I molecules is in dispute. The human, nonclassical class I gene, HLA-E, was found to be
ubiquitously transcribed, whereas cell surface expression was dif~cult to detect upon transfection.
Pulse chase experiments revealed that the HLA-E heavy chain in transfectants, obtained with
the murine myeloma...
1992-01-0100 minBiologie - Open Access LMU - Teil 02/02THE HLA-E GENE ENCODES TWO DIFFERENTIALLY REGULATED TRANSCRIPTS AND A CELL SURFACE PROTEINAn HLA-E-specific oligonucleotide probe was used
to study the expressioonf HLA-E. This probed etects
two HLA-E transcripts, 1.8 and 2.7 kb in size, which
are present in varying ratios in allt issues and cell
lines investigated. We demonstrate that alternative
poly(A) site usage accounts for the differential regulation
of the two HLA-E mRNA species. Sequence
analysis of three cDNA clones, representing the two
transcripts of HLA-E, and of anH LA-E gene encoded
by cosmid cd3.14, revealed identity of gene and
cDNA in the 3’ untranslated region. S1 nuclease
protection assays confirmed that the two HLA-E
transcripts are not alternative splicing products.
Introduction of...
1992-01-0100 minBiologie - Open Access LMU - Teil 02/02Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B allelesSeveral new HLA-B (B8, B51, Bw62)- and
HLA-C (Cw6, Cw7)-specific genes were isolated either as
genomic cosmid or cDNA clones to study the diversity
of HLA antigens. The allele specificities were identified
by sequence analysis in comparison with published HLAB
and -C sequences, by transfection experiments, and
Southern and northern blot analysis using oligonucleotide
probes. Comparison of the classical HLA-A, -B, and -C
sequences reveals that allele-specific substitutions seem
to be rare events. HLA-B51 codes only for one allelespecific
residue: arginine at position 81 located on the cd
helix, pointing toward the antigen binding site. HLA-B8
contains an acidic...
1989-01-0100 min