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The Miami Stem Cell Therapy Podcast2025-12-1906 min脑科学连线 BrainCast
脑科学连线 BrainCastEP20. 田瑞琳:CRISPR与iPSC助力神经退行性疾病研究公众号图文:https://mp.weixin.qq.com/s/v7oiJ-HttrieAyJMQbOATA嘉宾名片个人简介:田瑞琳,南方科技大学医学院助理教授、博士生导师。2015年毕业于北京大学生物科学专业,2015年9月至2020年12月在美国加州大学旧金山分校(UCSF)取得博士学位,并进行博士后训练,2020年底加入南方科技大学医学院。本课题组结合CRISPR基因表达调控系统(CRISPRi和CRISPRa)与人类诱导多能干细胞(iPSC)分化技术,开发出在人类神经元和神经胶质细胞中进行大规模遗传筛选的平台。本课题利用这一平台,并结合各种细胞分子生物学技术和单细胞测序等多组学方法,研究人类神经系统疾病的分子细胞生物学机制。实验室主页:www.sustech.edu.cn教育背景:2011.9-2015.6 本科 北京大学 生物科学2015.9-2020.6 博士 加州大学旧金山分校 生物物理工作经历:2020.6-2020.12 博士后 加州大学旧金山分校获奖情况及荣誉:2016年 Tau consortium fellowship by the Tau consortium2015年 北京市优秀毕业生2015年 北京大学优秀毕业生2014年 国家奖学金2013年 北京大学五四奖学金研究领域:1.  神经发育疾病和神经退行性疾病的分子细胞生物学机制2.  神经胶质细胞与神经元相互作用3.  基于CRISPR和诱导多能干细胞(iPSC)的遗传筛选方法的开发4.  单细胞组学/系统生物学代表文章:1. Tian, R.*, Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Nalls, M. A., ... & Kampmann, M.* (2021). Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nature Neuroscience, 24, 1020–1034 (*通讯作者)2. Tian, R.#, Gachechiladze, M.A.#, Ludwig, C.H.#, Laurie, M.T., Hong, J.Y., …, Ward, M.E. & Kampmann, M., (2019). CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron, 10.1016/j.neuron.2019.07.014 (# co-first authors,封面文章)3. Boettcher, M., Tian, R., Blau, J. A., Markegard, E., Wagner, R. T., Wu, D., ... & McManus, M.T., (2018). Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nature biotechnology, 36(2), 170.
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