ISSCR - Podcast Details

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The Stem Cell Report with Janet RossantStem Cells in Space: Muscle Regeneration in MicrogravitySkeletal muscle is one of the most abundant tissues in the human body, representing approximately 40% of body weight. Under certain circumstances, skeletal muscle can be regenerated through satellite cells, a reservoir of quiescent muscle stem cells, that can be activated with injury or in certain diseases and give rise to newly formed multi-nucleated myotubes and myofibers. However, the regenerative potential of muscle is diminished or is completely absent in the course of normal aging, certain diseases, and space travel. For example, time spent in microgravity can have a profound impact on human physiology, especially the muscular system, as astronauts...2025-07-0839 min

The Stem Cell PodcastEp. 298: “ISSCR 2025: On the Ground” In June 2025, we attended ISSCR 2025, the annual meeting of the International Society for Stem Cell Research, in Hong Kong. We spoke with delegates about their research, their impressions of the meeting, and the most memorable research presented. They also discussed their experiences exploring Hong Kong. Featured Products and Resources: Wallchart: Reporting Practices for Publishing Results with hPSCs 2025-06-2459 min

The Stem Cell PodcastEp. 297: “Live at ISSCR 2025: Advancing Regenerative Medicine with CiPSCs” Featuring Drs. Hongkui Deng and Candice Liew Guests: Dr. Hongkui Deng is the Director of the Institute of Stem Cell Research at Peking University and Dr. Candice Liew is a Senior Scientist at Reprogenix Bioscience. In this special episode recorded in front of a live audience at ISSCR 2025 in Hong Kong, they discuss their groundbreaking study transplanting CiPSC-derived islets into a patient with type 1 diabetes. They talk about their approach to chemical reprogramming, immune tolerance, and the therapy’s impact on the first patient. Featured Products and Resources: Wallchart: Directed Differentiation of ESCs and iPSCs Images cou...2025-06-171h 00

The Stem Cell PodcastISSCR 2025: Day 4 In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on cell therapy for spinal cord injury, immunocompatible pig organs, and community engagement. Featured Products and Resources: Are you taking a cell therapy to clinic? Work with a dedicated team that understands the path from bench to bedside. 2025-06-1428 min

The Stem Cell PodcastISSCR 2025: Day 3 In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss research on cell therapy for inflammatory bowel disease and hearing loss. They also talk about Dr. Jacob Hanna’s work on ex utero embryo culture, Dr. Paola Arlotta’s research on long-term brain organoids, and Di Pan’s insights into sponge regeneration. Featured Products and Resources: Get access to free, on-demand training courses...2025-06-1333 min

The Stem Cell PodcastISSCR 2025: Day 2 In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun cover talks on animal models of regeneration and the public perception of in vitro gametogenesis. They also discuss work on CiPSCs for Type 1 diabetes therapy and growing pig-human chimeric embryos. Featured Products and Resources: Explore the possibilities for reproducible, high-quality hPSC differentiation with easy-to-use serum-free kits. 2025-06-1234 min

The Stem Cell PodcastISSCR 2025: Day 1 In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss updates from clinical trials for ALS, congenital heart disease, and Parkinson’s disease. They also talk about the Presidential Plenary session, chaired by Dr. Valentina Greco. Featured Products and Resources: Start your research confidently with a reliable source of human iPSC products. 2025-06-1130 min

The Stem Cell PodcastEp. 295: “Roadmap for Cell Therapy Development” Featuring Drs. Jacqueline Barry, Kapil Bharti, and Jack Mosher Guests: Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR’s Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions. (44:59) Fe...2025-05-271h 25

The Stem Cell Report with Janet RossantParkinson's Disease, Cell Therapy, and ExerciseThe potential of pluripotent stem cells and the ability to scale and differentiate them to generate large numbers of enriched cell populations has created new opportunities and approaches to treat human disease. Preclinical proof-of-principle data demonstrates that stem cell-derived neural grafts can be used to reverse symptoms of multiple neurological conditions, including Parkinson’s Disease. Cell grafts enriched with dopaminergic neurons, can structurally and functionally integrate in the brain of Parkinson’s Disease models to reverse motor deficits, a finding which has launched several clinical trials. While the results in animal models is essential proof-of-concept, the survival and integration of t...2025-05-1338 min

Progress, Potential, and Possibilities Podcast / ShowDr. Kilian Kelly, Ph.D. - CEO, Cynata Therapeutics - iPSC-Derived, Mesenchymal Stem Cell TherapiesSend us a textDr. Kilian Kelly, Ph.D. is Chief Executive Officer and Managing Director of Cynata Therapeutics ( https://cynata.com/ ), a stem cell and regenerative medicine company that is known for its proprietary Cymerus platform, for the scalable and consistent production of mesenchymal stem cell (MSC)-based therapies.Unlike traditional MSC therapies that rely on multiple donors, the Cymerus manufacturing process ensures that cells for therapeutic use can be produced in virtually limitless quantities from a single donor – making the opportunities endless and attractive from a manufacturing standpoint. The company has completed Phase I...2025-04-081h 02

The Stem Cell Report with Janet RossantLeaving an Imprint: The Function, Impact, and Detection of Epigenetic MarksParent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 imprinted genes have been discovered, and improper imprinting can manifest in growth restriction, obesity, intellectual disabilities, behavioral abnormalities, and an increased risk of certain cancers. While the use of pluripotent stem cells, especially those in the naïve state, have advanced aspects of modeling early development, a persistent issue hampering bona fide naïve hPSCs is the erosion of imprints. Our guests on today's episode will discuss genomic imprinting, it...2025-04-0754 min

The Stem Cell Report with Janet RossantDon’t Dull the SPARCL: The Lung Microvasculature and its Role in DevelopmentThe mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological role in gas exchange within the tissue, but the vascular cells have additional role(s) beyond supplying oxygen and nutrients to the tissue. For example, the adult lung endothelium responds to injury by activating pathways for alveolar re epithelialization and during embryonic development, disrupting vascularization ex vivo affects the stereotypical pattern of airway branching, consistent with a perfusion-independent crosstalk between the endothelium and epithelium. Today’s guests explore the molecular contribution of ECs and...2025-03-2043 min

The Stem Cell PodcastEp. 290: “ISSCR 2025: Illuminating the Future” Featuring Drs. Valentina Greco, Kathryn Cheah, and Eugenia PiddiniDr. Valentina Greco is the President of the International Society for Stem Cell Research (ISSCR), and Professor of Genetics and Co-Chair of the Status of Women in Medicine at Yale University. Dr. Kathryn Cheah is an ISSCR Program Committee Co-Chair and Emeritus Professor and Chair of Biochemistry at Hong Kong University. Dr. Eugenia Piddini is also an ISSCR Program Committee Co-Chair and Professorial Research Fellow in Cell Biology and School Research Director at the University of Bristol. They talk about the upcoming ISSCR 2025 meeting in Hong Kong from June 11-14, 2025. They discuss the meeting's global focus, program highlights, opportunities for...2025-03-181h 22

The Stem Cell Report with Janet RossantA Look Into the Future of Stem Cell Reports: A Conversation with Janet RossantIn this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees as some of the exciting prospects over the horizon for stem cell research. We will also talk with Yvonne Fisher, the journal’s Managing Editor, and Jack Mosher of the ISSCR, about the evolution of the journal and its role in the Society. GuestsJanet Rossant is the new Editor-in-Chief of Stem Cell Reports. She holds an appointment as the Chief of...2025-01-1357 min

Conversations with scientistsSneak-peek of the 2024 ISSCR annual meetingThis podcast was uploaded earlier this year but somehow it was deleted, sorry. So it's not quite a sneak-peek anymore...Whether or not you attended the 2024 annual meeting of the International Society for Stem Cell Research (ISSCR) or not, you might enjoy this conversation. It's with Dr. Amander Clark from the University of California at Los Angeles, she is also the current president of the ISSCR; Dr. Malin Parmar from Lund University and Dr. Agnete Kirkeby from the University of Copenhagen. They are program chairs of the ISSCR meeting. My co-host is manuscript editor Dr. Stylios Lefkoupolos from Nature C...2024-12-1545 min

The Stem Cell Report with Janet RossantSeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality AssessmentDuring the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, mutations, on-target and off-target editing errors, and microbial contamination can arise during PSC culture or due to undesired editing outcomes. To ensure valid experimental results and the safety of PSC-derived therapeutics, it is important to detect these abnormalities and choose PSC lines without them. Existing quality control methods typically focus on detecting one type of abnormality. Whole genome sequencing is an all-in-one...2024-12-0934 min

The Regenerative Health Podcast from TheRHA.orgAn Overview of The ISSCR Guide to Stem Cell TreatmentsListen in as The Regenerative Health Association hosts review The International Society for Stem Cell Research (ISSCR) Guide to Stem Cell Treatments. The ISSCE is a global nonprofit professional societythat promotes stem cell science andregenerative medicine and its applications to humanhealth. It's mission is to sharescientifically accurate information to inform patientsand families about the current state of stem cellresearch and potential treatments. The ISSCR aimsto further patient safety and public health throughour efforts to promote legitimate stem cell researchand cre...2024-12-0423 min

The Stem Cell Report with Janet RossantGuidelines for Managing and Using the Digital Phenotypes of Pluripotent Stem Cell LinesThe ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and disease. As a result, these cells are shared, edited, and differentiated by laboratories across the world for basic research, clinical translation, and commercial applications. Large and genotypically diverse collections of pluripotent stem cells are being generated to support large cohort-scale research into conditions such as Parkinson’s disease and amyotrophic lateral sclerosis, among many others. However, information about these cells, their derivatives, and the resulting data can be difficult to track du...2024-11-1253 min

The Stem Cell Report with Janet RossantPSC Developmental Bias: The Mechanism and the Variation in Human Neural DevelopmentPluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field that there is variability in developmental potential between cell lines. This phenomenon, sometimes referred to as lineage bias, is manifest in a variable response of individual cell lines to induction of differentiation into a specific germ layer lineage. Although lineage bias in pluripotent stem cells has been reported for some years, we do not fully understand its molecular basis, or its implications for normal development. The guests on today’s program st...2024-10-2542 min

The Stem Cell Report with Janet RossantAging, Stem Cells, and Biological ClocksEpigenetic clocks based on tissue DNA methylation analysis have emerged as robust and powerful biomarkers of aging. This technology has allowed scientists to investigate how diseases affect the aging process, to evaluate the effectiveness of therapeutic aging interventions, and to correlate age with overall health among the general public. Today you can even purchase test kits online that enable you to measure your own biological age. However, despite the growing use of epigenetic clocks in research, surprisingly little is known about the aging clock’s cellular underpinnings. For example, it remains unclear whether all cells within a tissue exhibit the...2024-09-1039 min

The Stem Cell Report with Janet RossantEvaluating the Expanding Models of Brain DiseaseThose who study neurological diseases and their underlying cellular and molecular mechanisms have a number of scientific models at their disposal. In vivo animal models, particularly those bearing targeted genetic modifications, remain the gold standard, especially when it comes to assessment of behavioral readouts and neurobiological disease mechanisms in vivo. Historically, animal models have been widely used for preclinical validation of drug efficacy and safety. Increasingly there is a move away from this approach, and human cellular models using induced pluripotent stem cells and their derivatives such as three-dimensional organoid models have recently provided unprecedented genetic and m...2024-08-1251 min

The Stem Cell PodcastISSCR 2024: On the GroundIn July 2024, we attended ISSCR 2024, the annual meeting of the International Society for Stem Cell Research, in Hamburg, Germany. We spoke with delegates about their research, their impressions of the meeting, and the most memorable research presented. They discussed their experiences in Europe and where they would like to see the meeting go next.2024-07-3043 min

The Stem Cell PodcastEp. 272: “Live at ISSCR 2024: Stem Cell Research in Space” Featuring Drs. Davide Marotta and Catriona JamiesonDr. Davide Marotta is the Program Director for In-Space Biomanufacturing at the International Space Station National Laboratory. Dr. Catriona Jamieson is the Director of the Sanford Stem Cell Institute at the University of California, San Diego. In this special episode recorded in front of a live audience at ISSCR 2024 in Hamburg, Germany, they talk about the opportunities and challenges of working with stem cells in a microgravity environment, and what this could mean for the future of stem cell-based therapies. They discuss the challenges of culturing cells in space, the need for risk reduction and collaboration, and how microgravity affects s...2024-07-2359 min

The Stem Cell PodcastISSCR 2024: Day 4In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on stem cell research in space, regulatory and ethical considerations for human embryo models, and developing therapies for SCID, epilepsy, and spinal cord injury. Daylon and Arun also discussed work on salivary gland organoids and patient advocacy in Parkinson's disease research.2024-07-1426 min

The Stem Cell PodcastISSCR 2024: Day 3In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes from the meeting. Highlights from Day 3 include Dr. Yasuhiro Takashima's work on bilaminoids, Dr. Clive Svendsen's talk on organoid models for ALS, Dr. Sharon Gerecht's research on modeling the microenvironment, and Dr. Katsuhiko Hayashi's work with gonadal organoids.2024-07-1231 min

The Stem Cell PodcastISSCR 2024: Day 2In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes from the meeting. Highlights from Day 2 include Dr. Helmuth Gehart's work on mesothelioma organoids, Dr. Kyoko Miura's research on aging in naked mole rats, and Dr. Mansi Srivastava's talk on panther worms to study pluripotency during development.2024-07-1130 min

The Stem Cell PodcastISSCR 2024: Day 1In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss the clinical focus of this year's meeting and the President's Symposium, including Dr. Magdalena Götz's talk on organellar heterogeneity and "moonlighting" proteins. They also talk about sessions on stem cells in low earth orbit and computational biology, including Dr. Jonathan Weissman's work on PerturbSeq and Dr. Matthias Lutolf's work on organoids on chips. Finally, they discuss a ses...2024-07-1041 min

Conversations with scientistsSneak-peek of the ISSCR annual meeting 2024Stem cells are intriguing cells with a lot of flexibility in their biographies. And these cells are the focus of the annual meeting of the International Society for Stem Cell Research, ISSCR. It's happening soon: in July. Here is a sneak-peek of the meeting with the ISSCR leadership: Dr. Amander Clark from the University of California at Los Angeles, she is the current president of the ISSCR. Dr Malin Parmar from Lund University and Dr Agnete Kirkeby from the University of Copenhagen. They are program chairs of the ISSCR meeting. Co: host: Dr. Stelios Lefkoupolos from Nature Cell Biology...2024-06-2345 min

The Stem Cell Report with Janet RossantGoing Out on a LIM: Rethinking the Role of LMX1A in Patterning Dopaminergic NeuronsThis episode of The Stem Cell Report will discuss the process of directing stem cells to acquire the proper identity, an essential step in the development of effective and durable cell replacement therapies. Specifically, we will talk about the process of directing cells into a ventral mesencephalic dopaminergic fate for treating Parkinson’s disease. GuestsAgnete Kirkeby is an Associate Professor in the Department of Neuroscience at the University of Copenhagen, a Principal Investigator with the Novo Nordisk Foundation Center for Stem Cell Medicine renew, and a Principal Investigator at the Wallenberg Cen...2024-06-1130 min

The Stem Cell Report with Janet RossantNo Oligo Monopoly: Oligodendrocyte Precursor Cells in the Developing CortexMyelination is one of the last events during mammalian brain development and is thought to continue into young adulthood in humans. Even in adulthood, ongoing low-level myelination is essential for neural homeostasis, and for dynamic processes such as learning and memory. Deficits in myelination resulting in abnormal white matter and disruption of neuronal function are observed in a wide variety of disorders of the CNS. One strategy for alleviating these deficits is to enhance the genesis of myelin-forming oligodendrocytes from their upstream precursor parents, oligodendrocyte precursor cells (OPCs). However, the capability of these OPCs to contribute to remyelination in...2024-05-2037 min

The Stem Cell Report with Janet RossantEnhancing Connections: Rebuilding Neural Circuits in Spinal Cord InjuryBiomedical researchers have long sought ways to repair spinal cord damage with the holy grail of the pursuit being the reconstitution of lost function. In the mid 1990’s with the successful culture of human embryonic stem cells, and about a decade later induced pluripotent stem cells (iPSCs), the field was energized with a potential new approach to replace the lost neurons and glia cells and restoring neural connections. In the decades since that discovery some progress has been made, however many hurdles remain, including establishing a functional synaptic connection between the transplanted and host neurons which is crucial for mot...2024-04-0924 min

The Stem Cell PodcastEp. 263: “ISSCR 2024: The Global Stem Cell Event” Featuring Drs. Amander Clark, Agnete Kirkeby, and Malin ParmarDr. Amander Clark is the President of the International Society for Stem Cell Research (ISSCR) and Founding Director of the Center for Reproductive Science, Health, and Education at the University of California, Los Angeles. Dr. Agnete Kirkeby is a Program Chair of the ISSCR Annual Meeting, Associate Professor at Lund University and the University of Copenhagen, and Group Leader at the Novo Nordisk Foundation Center for Stem Cell Biology – reNEW. Dr. Malin Parmar is a Program Chair of the ISSCR Annual Meeting, Professor at Lund University, and a New York Stem Cell Foundation – Robertson Investigator. They talk about the upcoming ISSC...2024-03-191h 11

The Stem Cell Report with Janet RossantClimbing the Scientific Mountain of Retinal RegenerationCollectively, retinal degenerative disorders are a major cause of blindness worldwide. For example, one of the most common disorders is age related macular degeneration, which alone affects nearly 200 million globally. In humans, and other mammals, the loss of the retinal cells is an irreversible process. However, in some non-mammalian vertebrates like frogs and fish, retinal neurons can regenerate. This process is dependent upon Müller glia, which can re-enter the cell cycle and reprogram into neurogenic progenitors upon retinal injury or disease. Progress has been made in understanding the genetic program underlying these regenerative process, and proof-of-principle ex...2024-03-1143 min

The Stem Cell Report with Janet RossantHuman Fetal Tissue: A Legacy of Biomedical Research ContributionsSince the 1930’s research using human fetal tissue has been used in numerous scientific and medical advances that have saved millions of lives, including the development of vaccines and treatments for diseases. Despite its substantial contribution to medicine and science, significant public debate and misinformation persists surrounding the ethical use of human fetal tissue in biomedical research. The ISSCR, led by its Public Policy Committee, have been tireless champions and advocates for sound science policy across the globe. This includes advocacy for fetal tissue research and working to inform policymakers and the public on the vast medical app...2024-02-1237 min

The Stem Cell Report with Janet RossantThe Selling of Stem CellsThis November marks the 25th anniversary of the successful isolation and culture of human embryonic stem cells by Jamie Thompson. This breakthrough was a turning point in biomedical research. This discovery provided scientists with a limitless source of human cells to understand human biology and model disease. The discovery also provided a novel pathway to develop tissues and cells that could potentially be used to provide curative diseases like diabetes and Parkinson’s, among others. To date, numerous companies are advancing human embryonic stem cell-based therapies in over 50 approved and regulated clinical trials. However, in parallel to the...2023-11-1348 min

The Stem Cell Report with Janet RossantSetting the Standards for Human Stem Cell ResearchHuman stem cell technology has led to remarkable insights into human biology in health and disease. However, for the results and outputs from this research to be accurate, meaningful, and durable, it is important that the field have agreed upon standards that ensure reproducibility and reliability of the data. The International Society for Stem Cell Research (ISSCR) has developed a set of recommendations, including reporting criteria, for scientists in basic research laboratories. These criteria are designed to be technically and financially feasible and, when implemented, to enhance the reproducibility and rigor of stem cell research. The guests o...2023-09-1252 min

The Stem Cell Report with Janet RossantOrganoids: Multi-Dimensional Standards for Three Dimensional ModelsThe use of organoids as an experimental system is rapidly advancing in pace and complexity. Derived from pluripotent or tissue stem cells, organoids are three-dimensional, in vitro, structures intended to model functional or developmental aspects of in vivo organs. They are also being used to model complex physiological systems in organ-on-chip devices and in assembloids, the combination of organoids from different tissues. Organoids are especially useful to model and understand aspects of human biology and pathology. This approach has led to much hope, and proof-of-principle findings, that these structures can serve as human avatars to advance the discovery of...2023-08-0738 min

The Stem Cell PodcastISSCR 2023: On the GroundIn June 2023, we attended ISSCR 2023, the annual meeting of the International Society for Stem Cell Research, in Boston. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending, what they were most looking forward to, and the most memorable research presented.2023-07-1141 min

The Stem Cell Report with Janet RossantBrushing Up on Tooth Biology: New Tools for Understanding Tooth DevelopmentWhile teeth have evolved over millions of years, scientists are still working to understand how teeth develop, a process formally known as Odontogenesis. Our guests today have developed a new model of mouse tooth development using long-term expandable 3D tooth organoids from postnatal mouse molars and incisors. This novel mouse model provides a valuable tool to study mouse tooth dental epithelial stem cells, dental epithelial-mesenchymal interactions, and differentiation processes, while allowing further elucidation of tooth type-specific features. These models, in combination with human tooth organoids, have great potential to further unravel tooth biology and repair and may be an...2023-07-1054 min

The Stem Cell PodcastISSCR 2023: Day 4In June 2023, Daylon and Arun attended the International for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the final day of the meeting.2023-06-1837 min

The Stem Cell PodcastISSCR 2023: Day 3In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the third day of the meeting.2023-06-1730 min

The Stem Cell PodcastISSCR 2023: Day 2In June 2023, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the second day of the meeting.2023-06-1636 min

The Stem Cell PodcastISSCR 2023: Day 1In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the first day of the meeting. They discuss the pre-meeting workshops, including Arun's own talk on stem cell research in space, as well as highlights from the morning's focus sessions and innovation showcases. They also dive into the Presidential Symposium and the new technologies presented in Plenary II.2023-06-1521 min

The Stem Cell Report with Janet RossantThe Satellite View: Muscle Stem Cells and Muscle DiseaseOver the last 10 years of Stem Cell Reports, the journal has published nearly 2,000 papers across the breadth of stem cell research. In this special episode of the podcast, we are celebrating the anniversary of the journal by talking with the authors from some of the most highly cited publications in the journal's history.The guests on this episode of the podcast have collective expertise that makes them the “dream team” of muscle stem cell biology and its application to treat disease. Akitsu Hotta is a Principal Investigator and Associate Professor in the Department of Cli...2023-05-1635 min

The Stem Cell Report with Janet RossantFocusing on the Aberration: Learning From PSCs Chromosomal AbnormalitiesHuman pluripotent stem cells have an unlimited capacity to self-renew in culture. This feature, along with their ability to become any cell type in the adult body, makes them a unique tool to study human biology in health and disease. Unfortunately, human pluripotent stem cells have a propensity to acquire genetic abnormalities in culture that may limit their scientific and clinical use.Among the most prevalent genomic changes found in pluripotent stem cells are various forms of over-representation of sequences on the long arm of chromosome 20, with up to 20% of tested cultures containing such an aberration. One...2023-04-1148 min

The Stem Cell Report with Janet RossantPiWi – The Not-So-Small and Expanding Role of RNA Binding ProteinsThe PiWi family of genes may have a diminutive sounding name, but they have a large role in the function of the germline and germline stem cells. Initially discovered in Drosophila, these highly conserved RNA-binding proteins have well-established roles in the regulation of spermatogenesis and germ stem cell maintenance, in addition to silencing transposable elements. However, PiWi function outside of the germline is relatively unexplored. New findings from the Lin laboratory show that Drosophila Piwi has a role in intestinal homeostasis where it functions to establish intestinal stem cells, maintain the enteroblast lineage, and support of the enterocytes. It...2023-03-1339 min

The Stem Cell PodcastEp. 236: “ISSCR 2023: The Future Starts Here” Featuring Keith Alm, Dr. Haifan Lin, and Dr. David ScaddenKeith Alm is the CEO, Dr. Haifan Lin is the President, and Dr. David Scadden is 2023 Annual Meeting Program Chair of the ISSCR. They talk about the upcoming annual meeting being held this year in Boston, a biotech hub with a vibrant stem cell research community. They discuss the highlights of this year's program including speakers, award winners, and more. They also discuss making this year's meeting more accessible to trainees and researchers around the world.2023-02-211h 03

The Stem Cell Report with Janet RossantLessons Learnt, and Still to Learn, in Stem Cell TrialsThis episode is sponsored by Bio-Techne. While advances in stem cell science have led to an increasing number of stem cell-based therapies entering clinical trials, the field is still relatively immature. Thus, these first-in-human trials are using pioneering approaches unique unto themselves, leaving scientists, physicians, and regulators to assess the best approaches for a specific therapy and/or disease. In this episode of the podcast, Martin Pera is joined by physician-scientists Roger Barker and Rajesh Rao who have and are leading stem cell-based trials to discuss some of the critical aspects of the process and reflect on t...2023-02-141h 11

The Stem Cell Report with Janet RossantComputing Positional Cues: From Single Cells to Embryo DevelopmentThis episode is sponsored by Bio-Techne.Computational approaches have become integral to understanding biological processes, in part because of a need to come to grips with the enormous amounts of high dimensional data that we generate using our current tools for cellular analysis. This is especially relevant for stem cell and developmental biology where development, disease modeling, regulatory networks, and lineage formation all lend themselves to the combination of experimental and computational methods. Today’s program explores how computational biology approaches can be used to understand and model early development, specifically the lineage commitment of the early em...2022-12-1338 min

The Stem Cell Report with Janet RossantInterspecies Chimerism: Advances, Applications, and ChallengesThis episode of The Stem Cell Report will explore the scientific applications, advances, and challenges of interspecies chimeras – organisms consisting of cells from at least two different species. The development of interspecies chimeras, most recently advanced by the discovery of pluripotent stem cells and enhancements in genetic editing, have led to greater understanding of fundamental developmental and biological concepts, insight into evolution, and even the development of potential regenerative approaches for human health. Martin Pera will be joined by Drs. Ori Bar-Nur and Jun Wu, along with Joel Zvick, next generation scientists who are pioneering advances in interspecies chimera re...2022-10-1137 min

The Stem Cell Report with Janet RossantModeling Neuropsychiatric Disorders in a DishIn this episode of The Stem Cell Report, sponsored by Bio-Techne, we will explore the modeling of complex human neuropsychiatric diseases such as autism, bipolar disorder, and others using stem cell-based, three-dimensional culture models of the brain and its development. Martin Pera will be joined by Drs. Carol Marchetto and Rusty Gage, experts in the normal and pathological development of the brain. Carol Marchetto is an Assistant Professor in the Anthropology Department at the University of California, San Diego and an adjunct Assistant Professor at the Salk Institute. Rusty Gage is the Vi and John Adler Chair for Research...2022-09-1428 min

The Stem Cell Report with Janet RossantThe ISSCR and Two Decades of Stem Cell AdvancesTo celebrate the ISSCR’s 20th anniversary, Martin Pera is joined by three members of the ISSCR Board of Directors; Fiona Doetsch (Biozentrum at the University of Basel, Switzerland), Clerk of the ISSCR, Takanori Takebe (Cincinnati Children's Hospital Medical Center, USA/Tokyo Medical and Dental University and Yokohama City University, Japan) is a Director, and Leonard Zon (Boston Children’s Hospital, USA) is an Ex Officio member, past president, and founder of the ISSCR. In addition to running their own laboratories these scientists are part of the ISSCR leadership and will talk about the ISSCR’s history, impact, the recent...2022-07-1038 min

The Stem Cell PodcastISSCR 2022: On the GroundIn June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco. We spoke with delegates to get their impressions of the meeting. They discussed the most memorable research presented and shared their thoughts on the challenges facing the stem cell field.2022-06-2849 min

The Stem Cell PodcastISSCR 2022: Day 4In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four special episodes from the meeting.2022-06-1938 min

The Stem Cell PodcastISSCR 2022: Day 3In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four special episodes from the meeting.2022-06-1828 min

The Stem Cell PodcastISSCR 2022: Day 2In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four special episodes from the meeting.2022-06-1726 min

The Stem Cell PodcastISSCR 2022: Day 1In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four special episodes from the meeting.2022-06-1638 min

The Stem Cell Report with Janet RossantStem Cells in Translation: Focusing on the EyeIn this episode of The Stem Cell Report, Martin Pera is joined by three experts on the eye, its development, and disease processes. Dr. Mark Humayun is the Director of the Institute for Biomedical Therapeutics and Co-Director of the Roski Eye Institute at the University of Southern California. Dr. Anand Swaroop is a Senior Investigator in the Neurobiology, Neurodegeneration and Repair Laboratory at the National Eye Institute, and Dr. Masayo Takahashi is a pioneer in iPS-based approaches to treat eye disease and the President of Vision Care Inc., a venture that will focus on cell-based treatments for macular de...2022-05-2056 min

The Stem Cell Report with Janet RossantKeeping the Is(lets) on the Prize: Treating T1D with Stem Cell-based TransplantsIn this episode of The Stem Cell Report, Martin Pera is joined by Douglas Melton, a pioneer in the use of stem cell-based transplants to treat Type 1 diabetes, and Nayara Leite, a former postdoc in the Melton laboratory who now works for Vertex Pharmaceuticals, one of the companies currently testing stem cell-derived transplants for diabetes in clinical trials. Drs. Melton and Leite will talk about the concepts and issues around stem cell-based treatments for diabetes and their new paper that looks at ways to enhance the survival and function of the insulin producing islets.Guests 2022-04-0137 min

The Stem Cell PodcastEp. 214: “ISSCR 2022: 20 Years of Excellence” Featuring Dr. Melissa Little, Keith Alm, and Dr. Amander ClarkDr. Melissa Little is the President, Keith Alm is the CEO, and Dr. Amander Clark is the Vice President of the International Society for Stem Cell Research (ISSCR). They discuss what they're looking forward to at the upcoming ISSCR 2022 meeting, and the future of the organization and the stem cell research community.2022-03-221h 11

The Stem Cell Report with Janet RossantWhen ROCK Stops the Roll: Explaining the Aging Neural Stem Cell NicheIn this episode of the Stem Cell Report, Martin Pera is joined by a team of scientists from the Neural Stem Cell Institute in Rensselaer, NY, USA. Drs. Elizabeth Fisher, Xiuli Zhao, and Institute Director Sally Temple talk about their new paper on neural stem and progenitor cell function in the aging adult brain. They use live time-lapse imaging with computer-based image analysis to assess young and aged neural stem and progenitor cells in 3D brain structures to assess the mechanism underlying changes to the aging brain. GuestsSally Temple, PhD, Neural Stem Cell In...2022-03-0835 min

The Stem Cell Report with Janet RossantBreathing Easier – Stem Cells and Lung FunctionIn this episode, Drs. Shimpei Gotoh, Takahiro Suezawa, and Carla Kim join the podcast to talk about using stem and progenitor cells to understand the adult lung and model disease processes impacting lung function. Their research and discoveries provide insight into lung homeostasis, the potential for regeneration, and understanding diseases like pulmonary fibrosis and cancer.Drs. Gotoh and Suezawa are two of the authors of the recent paper ”Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids” in Stem Cell Reports. Dr Kim is a member of the Stem Cell Reports Editorial Board and an e...2022-02-0838 min

The Stem Cell Report with Janet RossantLinking Genetic Variants to Cell Phenotypes in Human iPSCsIn this episode, Drs. Fiona Watt and Alice Vickers join the podcast to talk about uncovering the relationship between genetic variants and cellular behavior. They recently developed a platform to quantify iPSC differentiation propensity to investigate the genetic contribution to phenotypic variability. Drs. Vickers and Watt are authors of the recent paper, "Plating human iPSC lines on micropatterned substrates relevels role for ITGBI nsSNV in endoderm formation” in Stem Cell Reports. GuestsFiona Watt, DPhil, Centre for Stem Cells and Regenerative Medicine, King’s College London Website: http://www.wattlab.org/ Alice V...2021-11-0937 min

The Stem Cell Report with Janet RossantMending a Broken HeartIn this episode Drs. Charles Murry and Kenta Nakamura join the podcast to talk about “cardiac remuscularization therapy,” and the general approach of transplanting human pluripotent stem cell-derived cardiomyocytes to restore cardiac function after injury.GuestsCharles Murry, MD, PhD, University of Washington and Sana BiotechnologyKenta Nakamura, MD, University of Washington and VA Puget Sound Healthcare System HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson Laboratory Twitter: @martinperaJAXSupporting DocumentDrs. Murry and Nakamura are two of the authors...2021-10-1238 min

The Stem Cell Report with Janet RossantThe Intersection of Stem Cells and EngineeringIn this episode Drs. Peter Loskill and Christine Mummery join the podcast to talk about the intersection of stem cells, microphysiological systems and organs-on-a-chip technology in understanding disease, screening drugs and personalized medicine. Drs. Loskill and Mummery are guest editors of a special issue on this topic appearing now in Stem Cell Reports. GuestsPeter Loskill, PhD W3-Professor for Organ-on-Chip Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS). Twitter: @pe_loskChristine Mummery, PhD, Professor of...2021-09-2328 min

The Stem Cell Report with Janet RossantHans’ Iliad: Troy, Adult Stems, and the EpitheliaIn this episode, sponsored by Bio-Techne, Drs. Hans Clevers and Kai Kretschmar join the podcast to talk broadly about the role of adult stem cells in tissue maintenance and repair. Specifically, they will focus on the expression and function of Troy and stem cells in the development and homeostasis of the epidermis, the outermost layer of the skin, that functions as a protective mechanical and biological barrier against injuries, pathogens and the loss of heat and water.GuestsHans Clevers, MD, PhD, is group leader at the Hubrecht Institute for Developmental Biology and Stem...2021-09-1338 min

The Stem Cell Report with Janet RossantTranscription Factor Dance Party - Building Dopaminergic NeuronsIn this episode, sponsored by bit.bio, Drs. Marius Wernig and Yi Han Ng join the podcast to talk about the directed differentiation of pluripotent stem cells into dopaminergic neurons. Their approach, which is based on the expression of specific transcription factors to drive cell fate directly to a specific neuronal identity, has been demonstrated to robust generalate functional dopaminergic neurons of midbrain character.GuestsMarius Wernig, MD, PhD, Associate Professor of Pathology at the Institute for Stem Cell Biology and Regenerative Medicine at Stanford UniversityWebsite: https://www.werniglab.org/2021-08-0942 min

The Stem Cell Report with Janet RossantCurbing Unproven Stem Cell-Based “Treatments”In this episode, Drs. Zubin Master, Kirstin Matthews, Mohamed Abou-el-Enein, and Sean Morrison join the podcast to talk about unproven stem cell-based interventions. These so-called “stem cell therapies” or “regenerative therapies” currently being marketed direct-to-consumers have insufficient evidence of safety and efficacy to justify their use and pose a potential risk to recipients. A recent paper from Masters, Mathews and Abou-el-Enein published in Stem Cell Reports discusses this global public health problem.GuestsMohamed Abou-El-Enein, MD, PhD, MSPH Keck School of Medicine, University of Southern California, USAZubin Master, PhD, Mayo Clinic, USAKirs...2021-07-0941 min

The Stem Cell Podcast“ISSCR 2021 Day 4” Featuring Dr. Sheila ChariIn June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, featuring Dr. Sheila Charli from Cell Stem Cell.2021-06-2645 min

The Stem Cell Podcast“ISSCR 2021 Day 2” Featuring Dr. Madeline LancasterIn June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting featuring Dr. Madeline Lancaster from the Medical Research Council (MRC) Laboratory of Molecular Biology, who was honored with the Dr. Susan Lim Award for Outstanding Young Investigator Lecture at the meeting.2021-06-2434 min

The Stem Cell Podcast“ISSCR 2021 Day 1” Featuring Dr. Chuck MurryIn June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting featuring Dr. Chuck Murry from the University of Washington, who presented during the Presidential Symposium: What's in a Germ Layer session on the first day of the meeting.2021-06-2340 min

The Stem Cell Report with Janet RossantStem Cells: From Cancer Vaccines to Space ResearchIn today’s episode, we will talk about new research on the use of an induced pluripotent stem cell-based vaccine to potentially protect against pancreatic cancer. This approach takes advantage of shared antigens between stem cells and pancreatic cancer cells and seeks to exploit them for clinical benefit. We will talk with the authors of this new research published in Stem Cell Reports on why they decided to pursue this approach, the background behind it, and whether this approach could work for other types of cancers. We also discuss some of Dr. Wu's other work, including research on stem ce...2021-06-0730 min