Shows
Eight Drugs a Week PodcastPharmacogenetics: Here, There and EverywherePharmacogenetics now surrounds us and is an efficient tool to prevent disease or to guide drug therapy. By studying polymorphisms in the genes coding for metabolism enzymes and drug transporters, we can have clues to help choose the right drug or adjust drug dosage. Not to mention that pharmacogenetics is the ideal companion for therapeutic drug monitoring for a comprehensive treatment optimization. Treatment failure and adverse drug reactions may, at least partly, be explained with pharmacogenetics and we have never been so close to large-scale implementation of this strategy. In this episode, the Chair and Vice-Chair o...2024-11-0721 minEight Drugs a Week PodcastTDM for beta-lactams in critical care: You know my name (Look up the number)Given we traditionally only monitored particular antibiotics to spare toxicity, and that beta lactams were widely considered such safe drugs, it was once difficult to imagine this drug class would become important TDM candidates. A bit more than a decade ago we started to see the first reports about augmented renal clearance in critically ill patients, often in situations in which antibiotic treatment was crucial, such as sepsis. TDM of beta lactams in the critical care is now recognised as a valuable tool to ensure adequate drug exposure and optimise therapeutic outcomes for these vulnerable patients. But the space...2024-08-1337 minEight Drugs a Week PodcastExploring new frontiers in TDM and toxicology (IATDMCT Banff 2024): Not a second time!This time, it’s the right time - not a second time, but a unique time - to take the road to Banff, Canada, for the 22nd edition of the IATDMCT annual congress. This time, following a very successful virtual edition in 2020, we are very glad to be meeting in person. And what a place to meet! - surrounded by Banff’s mountainous splendour. We are so grateful the congress organizing committee accepted the mission to make the show happen again, and we acknowledge the incredible work they’ve put behind two wonderful congresses. We hope att...2024-06-1925 minEight Drugs a Week PodcastMachine learning and AI for individualised therapy: Now and thenThere was a time when we performed laborious pharmacokinetic hand calculations to tailor drug dosages and regimens – a practice that can still be useful for those brave enough to perform logarithmic calculator manipulations. These days, we are fortunate to have an increasing number of software tools to help us with the task, however many rely on population pharmacokinetic models typically built with relatively small data sets, and often necessarily representing subpopulations with niche requirements. Tomorrow, our work will no doubt be helped by artificial intelligence and machine learning approaches, and we have already started to see such approaches applied in...2024-05-1327 minEight Drugs a Week PodcastIATDMCT Young Scientists: When I’m 64!This episode we're excited to introduce you to the young guns, the bright minds of the Young Scientist Committee of the IATDMCT, who are making waves in this ever-evolving field. Our guests are Lea Wagmann, Hualin Cai, and Sumith Mathew, each bringing their unique perspectives and experiences from Germany, China, and India, respectively. From their early inspirations to their current endeavours, we'll uncover what drives them and the impact they're making on the future of pharmacology and toxicology. We’ll delve into their expectations for the years ahead, exploring the forefront of the scene and the...2024-03-1231 minEight Drugs a Week PodcastGot to get microsampling into my life: Got to get you into my life!This episode is about a fairly recent development in TDM and clinical toxicology that has huge potential, which has actually been used for many decades. It was recently the 50th anniversary of the Guthrie method, where dried blood spots are used to screen inborn errors of metabolism in neonatal infants. Thanks to instrumental developments, dried blood spots, and more generally microsampling approaches, have been increasingly applied to quantify a wide range of drug entities. Although these approaches offer plenty of novel opportunities in our field, they are not without challenges and pitfalls. Our guests today a...2024-01-1633 minEight Drugs a Week PodcastBack to when it all started: Get back!The recent congress in Oslo was a huge success. We were very glad to catch up with colleagues and hear about some really excellent science. We also bumped into Steve Wong and Phil Walson, first and third presidents of the IATDMCT, and we were delighted they obliged us with an interview about the origins of the Association. Like with any good origin story, Steve and Phil are true superheroes. Both have held numerous leadership positions in their professions and in professional associations, achieved international cooperation agreements, and advocated nationally and internationally for the quality use o...2023-10-2037 minEight Drugs a Week PodcastPersonalized Under The Northern Sky! (IATDMCT Oslo 2023): Norwegian WoodIn this bonus episode, we delve into the upcoming IATDMCT congress that will take place September 24th to 27th in Oslo, Norway . It promises to be an exciting event with varied and highly novel sessions. Joining us today are esteemed IATDMCT scientists and local members of the congress organizing committee: Stein Bergan, Ida Robertson, and Anders Åsberg. We delve into their motivations to host the congress and discuss the inspiration behind the theme: 'Personalized under the Northern Sky.' Our guests elaborate on how they will weave this overarching theme through the whole event. We explore some c...2023-07-1124 minEight Drugs a Week PodcastTDM of antiretroviral drugs: The continuing story (of Bungalow Bill)…This episode is about the TDM of antiretroviral drugs, an area with a boom in research output in the late 90s and early 2000s, generating enough randomized controls trials for a substantial systematic Cochrane review on the topic (a rare thing for TDM research!). It’s an ever-evolving space, where drug regimens are continually refined with newer drug options with fewer adverse effects. However, we have learned a lot through concentration monitoring, and TDM continues to be very useful in optimizing treatment. As our title suggests, this is a continuing story. Our guests today are Natella Rakhmanina an...2023-06-0138 minEight Drugs a Week PodcastTDM of anticancer drugs: We can work it out!This episode is about the TDM of anticancer therapies, a space where there is a sense of frustration about body-size based dosing, but while concentration-based promises to make a difference to clinical care, it still feels that progress has been less than satisfying. Florian opens the episode with an ode to oncologists, a song from the heart to say: ‘We can work it out!’ Our guests today are Dirk Jan Moes and Vikram Gota, both very active in ‘working things out’ in the space, in different corners of the world. We unpack the many challenges but arrive...2023-04-0343 minEight Drugs a Week PodcastTDM of Biologics: “Tomorrow never knows”This episode is about the TDM of biologics, a therapeutic class that only really emerged into widespread use about 20 years ago – but that as a class represents a breakthrough for many therapeutic challenges. This area has some differences compared to traditional TDM of small molecules, and although it’s established for some biologics, the role for TDM in the space is, in a sense, still being determined. Florian has consequently titled this episode ‘Tomorrow never knows’ – a great song and a fitting title. Our guests today are Annick de Vries and Murray Barclay, and both have made i...2023-02-0323 minEight Drugs a Week PodcastTDM across the universe! “Across the universe”This episode we travel around the world and hear from Paula Schaiquevich (Argentina) and Smita Pattanaik (India). These impressive women are well known IATDMCT members and for building successful TDM services from scratch. Paula and Smita share excellent advice about where to start, how to grow, some typical challenges and how to face these. In this episode we hear about: expecting 'more pitfalls than happiness' when starting out in establishing a TDM service, and how to navigate this the importance of partnerships and how these steer the direction and success of services how to s...2023-01-0126 minEight Drugs a Week PodcastImmunosuppressive drugs TDM: It’s getting better! “Getting better”In our inaugural episode of Eight Drugs a Week we are very lucky to be joined by two former IATDMCT Presidents, Loralie Langman and Pierre Marquet. Both are very well known for their work with immunosuppressant drugs, particularly in the context of transplantation. In this episode we talk about: Planning the ideal immunosuppressant monitoring program in solid organ transplant recipients Why France is ahead of the curve in immunosuppressant TDM Why a particular mycophenolate TDM RCT is the ‘poster study’ for TCI in the TCI vs TDM debate Les...2022-10-0629 minEight Drugs a Week PodcastIntroducing Eight Drugs a Week! – The opening themeWelcome to Eight Drugs a Week! Join us on this journey as we catch up with colleagues around the world and discuss new developments in clinical pharmacology. Stay tuned for our inaugural episode, and subscribe wherever you get your podcasts 😉 Eight Drugs a Week is supported by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT). The personal views of the hosts and guests do not necessarily reflect the position of the Association. To join IATDMCT, visit https://www.iatdmct.org/member-join2022-10-0500 min