Shows
Base by Base300: Population-scale WGS links MHC class II antigen presentation to persistent Epstein–Barr virus (EBV) DNANyeo SS et al., Nature, doi:10.1038/s41586-025-10020-2 - Population-scale WGS reanalysis quantifies persistent EBV DNA and shows MHC class II–mediated antigen presentation predicts EBV DNAemia and links to autoimmune and respiratory disease. Key terms: Epstein–Barr virus, MHC class II, whole-genome sequencing, HLA, antigen presentation.
Study Highlights:Using whole-genome sequencing from UK Biobank (n≈490,560) and All of Us (n≈245,394), the authors extracted chrEBV-mapping reads, masked low-mappability regions, and defined EBV DNAemia (>1.2 genomes per 10^4 cells) in 9.7–11.9% of donors. They performed PheWAS, GWAS and ExWAS and identified 22 genome-wide significant loci and 686 missense variants across 148 genes with...
2026-02-2421 min
Seventy3【第507期】mHC：流形约束超连接的大规模稳定训练Seventy3：借助NotebookLM的能力进行论文解读，专注人工智能、大模型、机器人算法、crypto方向，让大家跟着AI一起进步。今天的主题是：mHC: Manifold-Constrained Hyper-ConnectionsSummary近年来，以 Hyper-Connections（HC） 为代表的研究，通过扩展残差流的宽度并多样化连接模式，对过去十年中广泛采用的残差连接范式进行了拓展。尽管这种多样化带来了显著的性能提升，但它从根本上破坏了残差连接所固有的恒等映射（identity mapping）属性，从而导致严重的训练不稳定性和可扩展性受限，并且还引入了显著的内存访问开销。为了解决这些问题，我们提出了 流形约束的 Hyper-Connections（Manifold-Constrained Hyper-Connections，mHC），这是一种通用框架：通过将 HC 的残差连接空间投影到特定流形上，以恢复恒等映射属性；同时结合严格的系统级优化，以确保整体效率。大量实证实验表明，mHC 能够有效支持大规模训练，在带来可观性能提升的同时，展现出更优的可扩展性。我们期待 mHC 作为 HC 的一种灵活且实用的扩展，能够促进对拓扑结构化网络架构设计的更深入理解，并为基础模型的演进指明富有前景的方向。原文链接：https://arxiv.org/abs/2512.24880
2026-02-1818 min
WHMP RadioMHC Kerstin Nordstrom with MHC Astronomy Prof. Ben Boatwright — Colonizing Mars?What's Cooking?
2/16: Elyse Moore --"Jolly Good Time in the Kitchen" GCC Senior Symposia Wednesday, 2/18, at 2pm
Writers' Block w/ Megan Zinn & acclaimed Lauren Groff about her new book Brawler
MHC Kerstin N. Nordstrom with MHC Astronomy Prof. Ben Boatwright — Colonizing Mars? Really?
Mandi Jo Henneke — Amherst Town Council president on budgets, schools, housing, and charter change.
2026-02-1625 min
SingularRadio - シンギュラーラジオ#33 DeepSeekの未来図：mHC／Conditional Memoryが示す進化と中国のエコシステムご視聴ありがとうございます！今回はDeepSeek R1が生んだ「GPU不要論」という誤解を整理しつつ、mHCとConditional Memoryという最新論文から次世代モデル（統合モデル／Model 1）の姿を論理的に予測しました。その技術的進化を、中国のオープン戦略・地政学・ロボティクスまで含めた文脈で読み解き、なぜ今DeepSeekを見るべきかを掘り下げます。Singular Radioは、専門家が本気で考えるテクノロジーと未来の議論を、水準を下げることなく社会に開く思考型メディアです。AIやシンギュラリティを入口に、世界がどこへ向かっているのか、そして私たちは何を前提として考え直すべきかを掘り下げ、未来について主体的に思考するための問いと視点を共有します。お仕事の御依頼はsingularradio01@gmail.comまでご連絡ください。Apple Podcast: https://podcasts.apple.com/us/podcast/id1809437976Spotify: https://open.spotify.com/show/2nOYrpc9PhKQ5v7s81KzCWX (Twitter) アカウント：https://x.com/SingularRadioTIMESTAMPS:(00:00:00) オープニング：DeepSeek-R1から一年(00:01:28) R1論文とDeepSeekショックを振り返る(00:08:24) 次世代モデルの予測：mHC / Conditional Memory (00:22:03) 中国オープンモデルと半導体戦争本動画で参照した主要文献：1. DeepSeek-AI, “DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning,” arXiv:2501.12948, 2025. https://arxiv.org/abs/2501.129482. DeepSeek-AI, “mHC: Manifold-Constrained Hyper-Connections,” arXiv:2512.24880, 2025. https://arxiv.org/abs/2512.248803. Cheng, X. et al., “Conditional Memory via Scalable Lookup: A New Axis of Sparsity for Large Language Models,” arXiv:2601.07372, 2026. Peking University; DeepSeek-AI.#singularradio #deepseek #model1 #chinaai
2026-01-2738 min
Colaberry AI PodcastDeepSeek’s MHC: Smarter Architecture Over More Compute | 07th Jan 2025Send us Fan MailHow Parallel Reasoning Channels Are Redefining AI ScalingIn this episode of the Colaberry AI Podcast, we explore a major architectural breakthrough from the Chinese AI firm DeepSeek known as Manifold Constrained Hyperconnections (MHC)—a technique that challenges one of the most persistent limitations in modern AI design. For over a decade, large models have relied on narrow internal information pathways that create bottlenecks for complex reasoning, especially in logic and mathematics.While previous efforts to widen these pathways often led to training instability an...
2026-01-0713 min
Artificial Intelligence : Papers & ConceptsDeepSeek mHCWhy do some large AI models suddenly collapse during training—and how can geometry prevent it? In this episode of Artificial Intelligence: Papers and Concepts, we break down DeepSeek AI's Manifold-Constrained Hyperconnections (mHC), a new architectural approach that fixes training instability in large language models. We explore why traditional hyperconnections caused catastrophic signal explosions, and how constraining them to a geometric structure—doubly stochastic matrices on the Birkhoff polytope—restores stability at scale. You'll learn how mHC reduces signal amplification from 3,000× to ~1.6×, enables reliable training of 27B-parameter models, and even improves reasoning performance—all with minimal ov...
2026-01-0512 min
Build Wiz AI ShowDeepSeek: Manifold-Constrained Hyper-Connections (mHC)This episode explores Manifold-Constrained Hyper-Connections (mHC), a framework designed to solve the training instability and memory overhead issues found in existing Hyper-Connection architectures. We discuss how mHC uses the Sinkhorn-Knopp algorithm to project residual connections onto a doubly stochastic manifold, effectively restoring the "identity mapping" property essential for stable signal propagation. Finally, we examine the infrastructure-level optimizations—such as kernel fusion and selective recomputing—that allow mHC to achieve superior scalability and performance in large-scale foundation models.
2026-01-0313 min
Daily Paper CastmHC: Manifold-Constrained Hyper-Connections
🤗 Upvotes: 73 | cs.CL, cs.AI, cs.LG
Authors:
Zhenda Xie, Yixuan Wei, Huanqi Cao, Chenggang Zhao, Chengqi Deng, Jiashi Li, Damai Dai, Huazuo Gao, Jiang Chang, Liang Zhao, Shangyan Zhou, Zhean Xu, Zhengyan Zhang, Wangding Zeng, Shengding Hu, Yuqing Wang, Jingyang Yuan, Lean Wang, Wenfeng Liang
Title:
mHC: Manifold-Constrained Hyper-Connections
Arxiv:
http://arxiv.org/abs/2512.24880v1
Abstract:
Recently, studies exemplified by Hyper-Connections (HC) have extended the ubiquitous residual connection paradigm established over the past decade by expanding the residual stream width and diversifying connectivity patterns. While yielding sub...
2026-01-0220 min
USMLE DREAMERSEpisodio – Defecto en la acidificación lisosomal y disminución de MHC-II | USMLE Step 1En este episodio analizamos un escenario inmunológico fundamental: la presentación antigénica por MHC clase II y cómo un bloqueo experimental —la falta de acidificación lisosomal— altera por completo la interacción entre células presentadoras de antígeno (APC) y linfocitos T CD4⁺.Repasamos el mecanismo normal: los patógenos extracelulares son fagocitados, sus proteínas se degradan en lisosomas acidificados, y los péptidos resultantes se cargan sobre MHC clase II para posteriormente expresarse en la superficie de la APC. Esta interacción con el T-cell receptor (TCR) del linfocito T CD4⁺ es esencial p...
2025-11-2004 min
Big Scary ShowBIG SCARY SHOW - Episode 341 - MHC IS COMING!New BIG SCARY SHOW - Episode 341 - MHC IS COMING!Episode 341It’s almost June. The weather is warming up, the humidity is starting to rise, andhaunted house owners are busy hiring and working on their attractions for the Fall.We’ve officially passed the halfway point to October and there’s a lot of work to be done.Let the Big Scary Show Episode 341 keep you entertained and informed as you work onyour builds and make those building inspectors happy. (Remember, safety is sex...
2025-05-252h 24
Wilko’s Wealthy Wisdom - The PodcastAs the world dives deeper into all things Crypto, I had the privilege of sitting down with MHC Director Mark Carnegie to discuss the big changes ahead...Recently, I had Mark Carnegie from MHC Digital on my podcast to talk all things crypto. As a finance broker with over 20 years in the game, I’ve seen how conversations around money evolve—just 4-5 years ago, crypto was taboo, something no one wanted to touch. But now? It’s changing fast.
I don’t know exactly where crypto will land in the finance world, but one thing is clear—something big is coming. Mark, with his experience on Wall Street and deep understanding of digital assets, shares why he’s betting on crypto now. If you’re curio...
2025-03-3140 min
Cashflow QuestWhat MHC Lenders Look For & How to Secure the Best Loan with Art TuversonArt Tuverson is a highly experienced Managing Director of Mortgage Banking for Berkadia Manufactured Housing based in San Clemente, CA. With over 25 years of expertise, he specializes in providing debt and equity capital for various property types across the nation. Art’s focus lies in the manufactured housing community and RV resort industry, where he excels in arranging agency, conduit (CMBS), life company, bank, and bridge first mortgages. Additionally, he is well-versed in structuring participating debt, preferred equity, and joint venture equity arrangements.Listeners can connect with Art Tuverson on LinkedIn @ArthurWTuverson, and at BerkadiaNo...
2025-02-191h 03
Doctor Who: Mostly Harmless CutawayMHC #?36 Twice Upon a Time [Lost episode]CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Three Six featuring Caleb and Eric. Join us as we discuss our recent viewings of the UHD disc of Twice Upon a Time. This a lost cutbits episode that marked the first return to the MHC feed. This was the episode that inspired us to resurrect this feed, covering series 10 intending to publish this after those commentaries were completed. WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic e...
2024-12-2336 minDoctor Who: Mostly Harmless CutawayMHC #120 Last Christmas 8.13 [Lost Episode]CHRISTMAS: Welcome to Mostly Harmless Cutaway One Two Zero featuring Cat, Chris, Josh and Eric. Join us as we dive into our thoughts on the 2014 Christmas Special, Last Christmas. Let the banter begin! This is a Lost MHC recorded in 2015. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain t...
2024-05-101h 11
selbstorientiertMHC 1 und 2 einfach erklärt: Rezeptor | Unterschiede | Endogener und Exogener Weg (MHC I und MHC II)💛 Starte jetzt deine Physikums-Vorbereitung 💛
Kurs auf unserer Webseite ➡️ https://stifo.de/products/das-immunsystem-t-lymphozyten-lerneinheit?utm_source=copyToPasteBoard&utm_medium=product-links&utm_content=web
Vorbereitungskurs Physikum ➡️ https://www.selbstorientiert.org/shop/Physiologie-Vorbereitung-auf-das-Physikum-p523287523
Podcast (Spotify) ➡️ https://open.spotify.com/show/3gaHFsZG7QSeUZZDoTlY5j
Podcast (Apple) ➡️ https://podcasts.apple.com/de/podcast/selbstorientiert/id1493017734
🔴 Time-Stamps 🔴
0:00 Intro
0:32 MHC I und MHC I: Der endogene und exogene Weg
5:35 Die V(D)J-Rekombination
🟢 #MHC #MHC2 #Rezeptor🟢
🟡 MHC 1 und 2 einfach erklärt: Rezeptor | Unterschiede | Endogener und Exogener Weg (MHC I und MHC II) 🟡
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Nachweisfrei gemäß pixabay.com & pexels.com. Zur kommerziellen Nutzung freigegeben! Außerdem nutzen Wir Bilder, welche durch eine Künstliche In...
2024-04-0209 minDoctor Who: Mostly Harmless CutawayMHC #119 Death in Heaven 8.12 [Lost Episode]CREMATE ME: Welcome to Mostly Harmless Cutaway One One Nine featuring Cat, Chris, Josh and Eric. Join us as we dive into our thoughts on Series 8 Episode 12, Death in Heaven. Let the banter begin! This is a Lost MHC recorded in 2014. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT compl...
2024-03-061h 27Doctor Who: Mostly Harmless CutawayMHC #118 Dark Water 8.11 [Lost Episode]BUS: Welcome to Mostly Harmless Cutaway One One Eight featuring Josh, Chris and Eric. Join us as we dive into our thoughts on Series 8 Episode 11, Dark Water. Let the banter begin! This is a Lost MHC recorded in 2014. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This...
2024-02-221h 00
Doctor Who: Mostly Harmless CutawayMHC #117 In the Forest of the Night 8.10 [Lost Episode]Tree: Welcome to Mostly Harmless Cutaway One One Seven featuring Josh, Chris and Eric. Join us as we dive into our thoughts on Series 8 Episode 10, In the Forest of the Night. Let the banter begin! This is a Lost MHC recorded in 2014. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT co...
2023-11-2053 min
Doctor Who: Mostly Harmless CutawayMHC #115 Mummy on the Orient Express 8.8 [Lost Episode]CARE: Welcome to Mostly Harmless Cutaway One One Five featuring Josh and Eric. Join us as we dive into our thoughts on Series 8 Episode 8, Mummy on the Orient Express. Let the banter begin! This is a Lost MHC recorded in 2014. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to u...
2023-10-2439 min
Cartrack - Biznesowe Rozmowy FlotoweJak wyróżnić się na rynku usług CFM i dobrze zdefiniować potrzeby Klientów? - Sandra Szkwarek MHC MobilityPolski rynek usług car fleet management jest niezwykle rozbudowany i dojrzały. Przez ponad 20 lat usługi leasingu i wynajmu zaskarbiły zaufanie setek tysięcy przedsiębiorców oraz klientów indywidualnych. Ilość firm i dostępnych opcji finansowania aut służbowych oraz wynajmu jest ogromna.W jaki sposób zatem wyróżnić się na rynku usług CFM w Polsce i jak dobrze zdefiniować potrzeby Klientów? Na to kluczowe pytanie odpowiada Sandra Szkwarek, Head of Marketing & Product Development CEE MHC Mobility. Rozmawiamy na temat popularności leasingu, oczekiwań klientów oraz ewolucji r...
2023-10-1321 min
Doctor Who: Mostly Harmless CutawayMHC #113 The Caretaker 8.6 [Lost Episode]CARE: Welcome to Mostly Harmless Cutaway One One Three featuring Mark (@MarkCockram) and Eric. Join us as we dive into our thoughts on Series 8 Episode 6, The Caretaker. Let the banter begin! This is a Lost MHC recorded in 2014. LINKS: Doctor Who: All of Time and Space Podcast--Planet of Giants review, by Mark Cockram Featuring Eric Prognois Negative #40 The Time Machine (1960) review with Caleb, Sean, and Eric @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah...
2023-08-2850 minDoctor Who: Mostly Harmless CutawayMHC #171 The Space Museum 2.7 [Rare Aletory Review]DULL: Welcome to Mostly Harmless Cutaway One Seven One featuring Caleb, and Eric. Join us as we dive into our continuing series for the podcast where we use a randomiser to select a story from any Era of Doctor Who. This time focused on the First Doctor story, The Space Museum. Let the banter begin! This is the first Hartnell story to be officially reviewed on MHC! LINKS: Doctor Who: All of Time and Space Podcast--Planet of Giants review, by Mark Cockram Featuring Eric Prognois Negative #40 The Time Machine (1960) review with Caleb, Sean, and Eric @SciFiPartyLine: sci...
2023-07-191h 12
Naładowani TV - samochody elektryczne, stacje ładowania i elektromobilnośćSandra Szkwarek o MHC Mobility Day 2023MHC Mobility Day 2023 - co to jest? Dlaczego jest to ważne wydarzenie dla branży flotowej? Jak wygląda gra miejska z udziałem 60 samochodów elektrycznych? Między innymi na te pytania odpowiada Sandra Szkwarek z MHC Mobility.
Prowadzący:
Paweł Kacperek, bloger technologiczny - https://pawelkacperek.pl, @RaportTechnologiczny
Rozmówczyni:
Sandra Szkwarek, Head of Marketing & Product Development CEE w MHC Mobility - https://mhcmobility.pl
2023-06-1709 min
Doctor Who: Mostly Harmless CutawayMHC #144 The Return of Doctor Mysterio 9.14 [Lost Episode]SWALLOWED: Welcome to Mostly Harmless Cutaway One Four Four featuring Cat, Josh and Eric. Join us as we dive into The Return of Doctor Mysterio. Let the banter begin! This is a Lost MHC Episode recorded all the way back in 2016. WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood,Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT ideas, and as always expect strokes of innuendo throughout.
2023-06-141h 21Doctor Who: Mostly Harmless CutawayMHC #?29 Eve of the Daleks & The "Cut Bits" That Rebooted the PodcastCUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Two Nine featuring Sean, Caleb and Eric. Join us as we discuss the (then) recently released Eve of the Daleks, and discuss our (then) current states of mind with Doctor Who and Doctor Who podcasting. This is a lost "Cut Bits" from the bonus part of our discussion on Serial Mom (1994) recorded at the beginning of 2022, prior to Caleb and Eric rebooting the MHC feed. If you're interested in listening to the Serial Mom podcast, it can be found below or on The Novice Elitists Podbean link found in the lin...
2023-05-0811 minDoctor Who: Mostly Harmless CutawayMHC #151.5 The Pyramid at the End of the World 10.7 (Commentary)IS YOUR LOVE PURE?: Welcome to Mostly Harmless Cutaway One Five One.Five featuring Sean, Josh, and Eric. Join us as we dive into the Commentary for The Pyramid at the End of the World. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to...
2023-04-181h 13Doctor Who: Mostly Harmless CutawayMHC #150.5 Extremis 10.6 (Commentary)COUNT: I'M STILL BLIND: Welcome to Mostly Harmless Cutaway One Five Zero.Five featuring Sean, Josh, Caleb, and Eric. Join us as we dive into the Commentary for Extremis. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is...
2023-03-041h 27Doctor Who: Mostly Harmless CutawayMHC #169 Time-Heist 8.5 (Commentary)HEIST: Welcome to Mostly Harmless Cutaway One Six NINE featuring Josh, Caleb, and Eric. Join us as we dive a new series for the podcast where we use a randomiser to select a story from any Era of Doctor Who. Let the Commentary banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episode...
2022-12-101h 27Doctor Who: Mostly Harmless CutawayMHC #168 The Unquiet Dead 1.3 (Commentary)GELFLING: Welcome to Mostly Harmless Cutaway One Six Eight featuring Sean, Caleb, and Eric. Join us as we dive a new series for the podcast where we use a randomiser to select a story from any Era of Doctor Who. Let the Commentary banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episod...
2022-11-031h 24Doctor Who: Mostly Harmless CutawayMHC #149.5 Oxygen 10.5 (Commentary)BREATHE: THE DOCTOR, THAT'S WHO: Welcome to Mostly Harmless Cutaway One Four Nine.Five featuring Sean, Josh, Caleb, and Eric. Join us as we dive into the Commentary for Oxygen. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode...
2022-10-011h 03
Science SocietyUnmasking Leukemia: The Role of MHC:TCR Signaling with Dr. LaffeyThis episode delves into the cutting-edge research of Dr. Laffey, who has been investigating the role of Major Histocompatibility Complex:T cell antigen receptor (MHC:TCR) signaling in the development of T cell tumors. While this signaling pathway is crucial for T cell development and immune responses, it can also trigger the formation of T cell tumors under abnormal conditions.Dr. Laffey's research focuses on a low-frequency progenitor cell population known as Early αβ TCR+ Double-Negative (EADN) cells. Present in both mice and humans, these cells can transform into thymic leukemia. His work has shown that EADN cells do...
2022-09-091h 47Doctor Who: Mostly Harmless CutawayMHC #148.5 Knock Knock 10.4 (Commentary)THE DOCTOR, THAT'S WHO: Welcome to Mostly Harmless Cutaway One Four Eight.Five featuring Sean, Josh, Caleb, and Eric. Join us as we dive into the Commentary for Knock Knock. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY...
2022-08-231h 07
Doctor Who: Mostly Harmless CutawayMHC #148 Knock Knock 10.4 [Lost Episode]Who's There?: Welcome to Mostly Harmless Cutaway One Four Eight featuring Cat and Eric. Join us as we dive into "New" Doctor Who, Knock Knock. Let the banter begin. WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood,Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT ideas, and as always expect strokes of innuendo throughout. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn...
2022-07-2644 minDoctor Who: Mostly Harmless CutawayMHC #147.5 Thin Ice 10.3 (Commentary)BROKEN ICE: Welcome to Mostly Harmless Cutaway One Four Seven.Five featuring Sean, Josh, Caleb, and Eric. Join us as we dive into the Commentary for Thin Ice. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS...
2022-06-221h 06
Doctor Who: Mostly Harmless CutawayMHC #147 Thin Ice 10.3 [Lost Episode]PUNCHED: Welcome to Mostly Harmless Cutaway One Four Seven featuring Cat, Carl and Eric. Join us as we dive into Thin Ice. Let the banter begin. WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood,Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT ideas, and as always expect strokes of innuendo throughout. LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: ...
2022-05-311h 23
Search News You Can Use - SEO Podcast with Marie HaynesHow MHC Offers SEO to Clients, Discussions on Google Core Updates, and MoreIn this episode, Marie welcomes MHC’s director of products and services, Callum Scott. Callum has incredible knowledge of how Google’s algorithms work. In this episode, he and Marie discuss the following:
- May 16-18 - unnamed Google update affecting a large number of affiliate sites.
- How MHC’s site reviews developed over the years
- How we help sites improve their E-A-T
- Why knowing semantic search gets SEOs ahead of the game
- Google is likely a lexical search engine and a semantic search engine.
- Semantic search and E-A-T
- Register for SMX Advanced to hear M...
2022-05-2645 minDoctor Who: Mostly Harmless CutawayMHC #146.6 Smile 10.2 (Commentary)EXPRESSIONLESS SMILES: Welcome to Mostly Harmless Cutaway One Four Six.Six featuring Josh, Caleb, and Eric. Join us as we dive into the Commentary for Smile. Let the banter begin! LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT...
2022-05-251h 10
ModPath ChatMHC class I loss in endometrial carcinomaMHC class I loss by tumor cells decreases tumor neoantigen presentation to the immune system and therefore represents a possible mechanism of immunotherapeutic resistance in cancers that otherwise could be good candidates for checkpoint inhibition (e.g. mismatch repair (MMR)-deficient and PD-L1-positive tumors). In this episode our guest, Dr. Anne Mills discusses her recent Modern Pathology publication on loss of MHC class 1 expression in some endometrial cancers. Study by Friedman et al, MHC class I loss in endometrial carcinoma: a potential resistance mechanism to immune checkpoint inhibition. Modern Pathology, 34, 627-636, 2021. https://www.nature.com/articles/s41379-020-00682...
2021-03-0213 min
ModPath ChatMHC class I loss in endometrial carcinomaMHC class I loss by tumor cells decreases tumor neoantigen presentation to the immune system and therefore represents a possible mechanism of immunotherapeutic resistance in cancers that otherwise could be good candidates for checkpoint inhibition (e.g. mismatch repair (MMR)-deficient and PD-L1-positive tumors). In this episode our guest, Dr. Anne Mills discusses her recent Modern Pathology publication on loss of MHC class 1 expression in some endometrial cancers. Study by Friedman et al, MHC class I loss in endometrial carcinoma: a potential resistance mechanism to immune checkpoint inhibition. Modern Pathology, 34, 627-636, 2021. https://www.nature.com/articles/s41379-020-00682...
2021-03-0213 min
Mental Health CheckMHC 29: The Beginning of the EndI uploaded the first episode of MHC on July 16, 2019, and as we reach the one year anniversary of this show, I have also come to the conclusion that we should reach the end as well. Due to the current climate of the world, as well as my own personal uncertainties and feelings, I have decided that this shall be the penultimate episode of MHC. Today I touch on why, as well as on how mental health can affect a person's passions and lead to burnout.
2020-06-2320 min
Mason Hayes & Curran LLPMHC Let's Talk Legal Podcast - Tech at MHC Trends In Funding RecordingDisclaimer: The contents of this episode are to assist access to information and do not constitute legal or other advice. Specific advice should be sought in relation to specific cases.
If you would like more information on this topic, please contact events@mhc.ie
2020-04-0246 min
Mason Hayes & Curran LLPMHC Let's Talk Legal Podcast - E-ScootersThis episode looks at e-scooters and how they are dealt with under Irish law. We also examine calls for legislative change, safety concerns surrounding their use and the approach taken by legislators in other countries.
Get in touch with the MHC team - Brian McElligott, Intellectual Property Partner, and Lisa Joyce, Public, Regulatory & Investigations Partner : www.mhc.ie/people
2019-10-1113 min
Growing GardeniasBlack faces, white spaces with KerriAnne Sejour, MHC-LP.In this episode, I sit down with my good friend KerriAnne Sejour, MHC-LP and we have a candid conversation about being a black therapist, navigating white spaces, and mental health.
About KerriAnne: KerriAnne Sejour is an MHC-LP who graduated with a Bachelor of Arts in Psychology from Goucher College, received a Master of Arts in Counseling, and a Master of Education in Mental Health Counseling from Teacher College, Columbia University. KerriAnne’s Jamaican/Haitian background fuels her dedication to honor the multifaceted aspects of her client’s identities and she is attuned to the importance of topics and issues around cultu...
2019-09-3036 minMason Hayes & Curran LLPMHC Let's Talk Legal Podcast - Digital Health & GDPRIn this episode we take a look at digital health and GDPR.
Get in touch with the MHC team - Brian McElligott, Intellectual Property Partner, and Michaela Herron, Product Regulatory Partner: www.mhc.ie/people
2019-09-1011 min
Doctor Who: Mostly Harmless CutawayMHC #158.5 Jodie Says2 days until Rosa! ADDENDUM: Welcome to Mostly Harmless Cutaway One Five Eight Point Five featuring Josh and Eric. Join us as we do a double-take on NEW, new, new Doctor Who series opener The Woman Who Fell to Earth. Let the banter begin! WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood,Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT ideas, and as always expect strok...
2018-10-201h 01
Doctor Who: Mostly Harmless CutawayMHC #158 The Woman Who Fell to Earth 11.11 day until The Ghost Monument! MADAM: Welcome to Mostly Harmless Cutaway One Five Eight [glad to be back] featuring Carl and Eric. Join us as we dive into NEW, new, new Doctor Who series opener The Woman Who Fell to Earth. Let the banter begin! Blogpage poster art by Stuart Manning stuart-manning.tumblr.com WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood,Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not yet seen, do NOT complain to us. This episode...
2018-10-131h 09
Bella Smith's showMHC TetramerMHC Tetramers have emerged as an important tool for characterization of the specificity and phenotype of T cell immune response, useful in a large variety of disease and vaccine studies. Peptide-MHC multimers display an antigenic peptide in the MHC binding groove, functioning as a surrogate for recognition events that occur as part of the T cell interaction with antigen-presenting cell. The most prevalent form of multimer in use today consists of biotin-labeled pMHC displayed on streptavidin molecules, forming tetravalent complexes; so the common use of the term “tetramers” for this detection method. Since first description, MHC tetramers have become widely used...
2018-09-0900 min
Doctor Who: Mostly Harmless CutawayMHC #146 Smile 10.2 [Raw]65 days until The Doctor Falls! EXPRESSIONLESS: Welcome to Mostly Harmless Cutaway One Four Six featuring Caitlin, Carl, Cat, and Eric. Join us as we dive into NEW Doctor Who future-story Smile. Let the banter begin! This is the second RAW edition of MHC. Due to government cutbacks, we've had to tighten our belts and production, and have whittled the pod down to its bare essentials. We literally hit record, anything goes gaffes, swears, et al -- until we hit stop. Enjoy. Blogpage poster art by Stuart Manning stuart-manning.tumblr.com LINKS: @SciFiPartyLine: scifipartyline.com...
2017-04-261h 04
Doctor Who: Mostly Harmless CutawayMHC #145 The Pilot 10.1 [Raw]70 days until The Doctor Falls! POOLED: Welcome to Mostly Harmless Cutaway One Four Five featuring Carl, Cat, and Eric. Join us as we dive into the NEW Doctor Who soft-reboot The Pilot. Let the banter begin! This is the very first RAW edition of MHC. Due to government cutbacks, we've had to tighten our belts and production, and have whittled the pod down to its bare essentials. We literally hit record, anything goes gaffes, swears, et al -- until we hit stop. Enjoy. Blogpage poster art by Stuart Manning stuart-manning.tumblr.com LINKS:
2017-04-211h 38
Doctor Who: Mostly Harmless CutawayMHC #138 Nightvisiting 1.332 days until the 2016 Christmas Special! SKINNED: Welcome to Mostly Harmless Cutaway One Three Eight featuring Caitlin, Carl, Katrina, Cat, Josh, and Eric. Join us as we dive into the NEW Doctor Who spin-off Class and take a crack at the third episode, Nightvisiting. Let the banter begin! After the review Katrina poses a Twelve-centric query and Carl shares some (at time of recording) BREAKING not-Doctor Who news.... LINKS: @SciFiPartyLine: scifipartyline.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com @VerityPodcast: veritypodcast.wordpress.com @DWHighCouncil: dwhighcouncil.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC
2016-11-221h 32
Doctor Who: Mostly Harmless CutawayMHC #137 The Coach with the Dragon Tattoo 1.246 days until the 2016 Christmas Special! SKINNED: Welcome to Mostly Harmless Cutaway One Three Seven featuring Carl, Katrina, Josh, and Eric. Join us as we dive into the NEW Doctor Who spin-off Class and take a crack at the second episode, The Coach with the Dragon Tattoo. Let the banter begin! After the review we discuss The Power of the Daleks theatrical release.... LINKS: The Power of the Daleks US showings: bbcwpressroom.com @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com @VerityPodcast: veritypodcast.wordpress.com @DWHighCouncil: dwhighcouncil.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com...
2016-11-081h 17
Doctor Who: Mostly Harmless CutawayMHC #136 For Tonight We Might Die 1.156 days until the 2016 Christmas Special! BUNGHOLE: Welcome to Mostly Harmless Cutaway One Three Six featuring Carl, Katrina, Josh, and Eric. Join us as we dive into the NEW Doctor Who spin-off Class and take a crack at the premiere episode, For Tonight We Might Die. Let the banter begin! After the review we tell you about a NEW upcoming Doctor Who podcast/audio endeavor... LINKS: Dr Who's Line Is It?: @drwhosline @ProgNeg: prognosisnegative.libsyn.com @StarTrekRBG: startrekrbg.libsyn.com @VerityPodcast: veritypodcast.wordpress.com @DWHighCouncil: dwhighcouncil.libsyn.com Mostly Harmless Cutaway Patreon: patreon.com/MHC
2016-10-2951 min
Doctor Who: Mostly Harmless CutawayMHC #135 Tom's First Hour (Eleventh Hour Revisited)102 days until the 2016 Christmas Special! SCIENCYWIENCY: Welcome to Mostly Harmless Cutaway One Three Five featuring Tom, Josh, and Eric. Join us as we stroll back to classic NEW Doctor Who something that Josh and Eric have never covered together, The Eleventh Hour. This is Tom's formal introduction to Doctor Who, how will this play out? Let the banter begin! Near the end we touch upon Douglas Adams and The Power of the Daleks. Thanks to Tom @chewywater for being our plebe guinea pig. Tom can be heard regularly on Star Trek: RBG and (occasionally) Sci-Fi Party...
2016-09-131h 52
Doctor Who: Mostly Harmless CutawayMHC #134 Mad Men with a Box174 days until the 2016 Christmas Special! TOASTED: Welcome to Mostly Harmless Cutaway One Three Four featuring Josh and Eric. Join us as we dip into current Doctor Who goings on and delve into a little show Josh stumbled into during the hiatus, Mad Men. We also get you up to speed on where you can find us during the show and podcast off-season. Let the banter begin! Thanks to @digspinach for providing us with those vintage Cyber Testicles and @KrynoidPodCast for taking notice. Podcast coverart + blogpage poster art by Bosphorus society6.com/bosphorus LINKS: @ProgNeg...
2016-07-031h 11
Bio RadioMHCHør denne podcast med Katrine og kim, og bliv klogere på hvad Major Histocompatibility Complex er. Her bliver snakket om både HLA, MHC I og MHC II.
2016-05-3010 min
Doctor Who: Mostly Harmless CutawayMHC #112 Time Heist 8.5 [Lost Episode]229 days until the 2016 Christmas Special! TELLER: Welcome to Mostly Harmless Cutaway One One Two featuring Mark and Eric. Join us as we delve into the Peter Capaldi's fifth outing as The Doctor, Time Heist. Let the banter begin! For those who don't know, most of our Series 8 reviews were recorded in 2014, though never produced/released. Here's a treat for those of you who have waited for so long—we got your tweets. ;) Blogpage poster art by Stuart Manning stuart-manning.tumblr.com LINKS: Hustle (TV Series): en.wikipedia.org Mark @MarkCockram: Nerdology UK: nerdology-cockers.blogspot.co...
2016-05-0937 min
Doctor Who: Mostly Harmless CutawayMHC #111 Listen 8.4 [Lost Episode]320 days until the 2016 Christmas Special! SOLDIER: Welcome to Mostly Harmless Cutaway One One One featuring Chris and Eric. Join us as we delve into the Peter Capaldi's fourth outing as The Doctor, Listen. Let the banter begin! For those who don't know, most of our Series 8 reviews were recorded in 2014, though never produced/released. Here's a treat for those of you who have waited for so long—we got your tweets. ;) Blogpage poster art by Stuart Manning stuart-manning.tumblr.com WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, ne...
2016-02-081h 09
Doctor Who: Mostly Harmless CutawayMHC #?22 Cutbits: Joss Agnew and the Generic [Sixth Solar Circuit]355 days until the 2016 Christmas Special! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Two Two featuring Cat, Josh, and Eric. Today the podcast turns 6. This is our version of a SIXTH ANNIVERSARY SPECIAL. Join us as we get to the bottom of the infamous boy genius generic. Let the (archival) banter begin! Special thanks to Sarah Jane Adventures director, Joss Agnew who unwittingly participated. Classic coverart (from MHC #?1) by H.B. Lockwood @hayleyglyphs hayleyglyphs.tumblr.com LINKS: Joss Agnew: @JossAgnew | jossagnew.com WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah...
2016-01-0408 min
Doctor Who: Mostly Harmless CutawayMHC #133 The Husbands of River Song 9.13362 days until Next Christmas! TROWEL: Welcome to Mostly Harmless Cutaway One Three Three featuring Carl @robominister, Sean, Josh, and Eric. Join us as we delve into the eleventh Doctor Who Christmas Special, The Husbands of River Song. Let the banter begin! Thanks to @TARDISDatabanks, @leelinus75, @MarkBobJohn, and @HappyMrsRory2 for tweetback™. Very special thanks to our very first Patreon Patron: @MarkBobJohn! Blogpage poster art by Stuart Manning stuart-manning.tumblr.com LINKS: Bethany Black: @BeffernieBlack Bonobos on 60 Minutes: cbsnews.com Prognosis Negative: ProgNeg #21 Cube Sci-Fi Party Line: scifipartyline.com The Memory Cheats: thememorycheats.libsyn.com Mostly Ha...
2015-12-291h 42
Doctor Who: Mostly Harmless CutawayMHC #132 Series 9 Retrospecticus2 days until The Husbands of River Song! BRIE: Welcome to Mostly Harmless Cutaway One Three Two featuring Carl @robominister, Sean, Josh, and Eric. Join us as we delve into a very rare Retrospecticus for us. That's right, we're talking all of Series 9. Let the banter begin! Thanks to @comedyfish, @scarlettartlet, and @hal2814 for tweetback™. Very special thanks to our very first Patreon Patron: @MarkBobJohn! Blogpage poster art by Stuart Manning stuart-manning.tumblr.com LINKS: Sci-Fi Party Line: scifipartyline.com Prognosis Negative & Beam Me Up: prognosisnegative.libsyn.com ProgNeg #18 Dredd prognosisnegative.libsyn.com Mostly Harmless Cu...
2015-12-231h 49
Doctor Who: Mostly Harmless CutawayMHC #131 Hell Bent 9.1216 days until The Husbands of River Song! SOUP: Welcome to Mostly Harmless Cutaway One Three One featuring Carl @robominister, Cat, Josh, and Eric. Join us as we delve into the hotly anticipated final part of the series 9 three-parter, Hell Bent. Let the banter begin! Cold open cameo featuring Hanako @hmrpotter. Thanks to @walshcaitlin, @HappyMrsRory2, @CarpeCarne, @KrynoidPodCast, @GGossai, and @tardistavern for tweetback™. Blogpage poster art by Stuart Manning stuart-manning.tumblr.com WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor Who. If...
2015-12-091h 37
Doctor Who: Mostly Harmless CutawayMHC #?20 Paul Davis Sleeps No More7 hours until Heaven Sent! ROYALTY: Welcome to Mostly Harmless Cutaway Question Mark Two Zero featuring Josh and Eric. Now, for more unexpectedness as Eric interviews the illustrious actor and mostly director/writer, Paul Davis! For those who don't know, he played 'King Sandman' in Sleep No More. Let the banter begin! As mentioned, please check out the brand new MHC Patreon at patreon.com/MHC! Photo image/coverart courtesy Paul Davis. WARNING: This discussion contains miscellaneous K-9 and Company, Torchwood, Sarah Jane Adventures, Sherlock, Class, new WHO, and/or classic SPOILERS pertaining to Doctor...
2015-11-2852 min
Doctor Who: Mostly Harmless CutawayMHC #?18 Cutbits: Tres Companeez1 day until Face the Raven! CUTBITS: And now for something completely different... Welcome to Mostly Harmless Cutaway Question Mark Ten Eight featuring Sean, Josh, and Eric. That's right boys and girls, once again we're delving into some very exclusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. In this Cutbit, a first of sorts, we present to you our 'found footage' episode. Back in the day, especially during year one, this feed used to be host to lots of...
2015-11-2005 min
Doctor Who: Mostly Harmless CutawayMHC #?17 Cutbits: So Long, and Thanks for All the Fish1 day until Sleep No More! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Ten Seven featuring Cat, Josh, and Eric. That's right boys and girls, once again we're delving into some very exclusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. In this Cutbit, we ponder why the Moffat haters keep on hating. Inside baseball: This Cutbit was actually culled from MHC #127 and occurs after our discussion of The Zygon Inversion. Blogpage poster art and episode coverart by ki...
2015-11-1313 min
Doctor Who: Mostly Harmless CutawayMHC #?16 Cutbits: Girl Meets the War Games1 day until The Zygon Inversion!
CUTBITS:
Welcome to Mostly Harmless Cutaway Question Mark Ten Six featuring Cat, Josh, and Eric. That's right boys and girls, once again we're delving into some very exclusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day.
In this Cutbit, we ponder what Classic Who has Eric yet to watch?
Inside baseball: This Cutbit was actually culled from MHC #126 and occurs after our discussion of The Zygon Invasion.
WARNING:
This di...
2015-11-0611 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 16/19Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central toleranceThe immune system is highly organized and multifunctional; it protects the organism against invading pathogens (immune response), while at the same time being tolerant to ‘self’ (immune tolerance). Central tolerance is achieved during T-cell development by negative selection via self-peptide-MHC complexes (pMHC) presented by thymic dendritic cells (tDCs) and medullary thymic epithelial cells (mTECs). However, how self-antigens are processed into peptides that further are shuttled onto major histocompatibility complex (MHC) class II in thymic epithelial cells (TECs) is not fully understood. One candidate pathway involved in this process is macroautophagy (referred to as autophagy hereafter), originally thought to solely be invo...
2014-01-1500 min
Doctor Who: Mostly Harmless CutawayMHC #?13 Geeks WHO Drink + 50th Anni Trailer10 days until The 50th Anniversary Special! IMBIBE: Welcome to Mostly Harmless Cutaway Question Mark Thirteen featuring Steven, Josh, Kyle, and Eric. This time we're bringing you a brief PSA for Geeks WHO Drink. Because we haven't recorded fresh MHC in a while we also touch upon the recently released trailers for The Day of the Doctor. WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains...
2013-11-1215 min
Doctor Who: Mostly Harmless CutawayMHC #?12 Cutbits: Enemy of the Web World of Fear33 days until The 50th Anniversary Special! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Twelve featuring Steven, Josh, Kyle, and Eric. That's right boys and girls, once again we're delving into some very exclusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. Inside baseball: This Cutbit was actually culled from BMU #2. WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic episodes not ye...
2013-10-2105 min
Doctor Who: Mostly Harmless CutawayMHC #?11 Cutbits: Season 868 days until The 50th Anniversary Special! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Eleven featuring Erik, Chris, Kyle, and Eric. That's right boys and girls, once again we're delving into some very excusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. Inside baseball: This Cutbit was actually culled from the previous MHC #104. WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic ep...
2013-09-1604 min
Doctor Who: Mostly Harmless CutawayMHC #?10 Cutbits: Gerald C. Deville101 days until The 50th Anniversary Special! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark 10 featuring Eric, Josh, Kyle, and Steven. That's right boys and girls, for the tenth time we're delving into some very excusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. Inside baseball: This Cutbit was actually culled from upcoming SNS #23 Skyfall. What's Shaken Not Stirred you ask? Why it's our series of 007 commentaries housed on our supplemental Doctor Who podcast feed Prognosis Negative. If...
2013-08-1306 min
Doctor Who: Mostly Harmless CutawayMHC #94 The Bells of Saint John 7.74 days until The Rings of Akhaten!
SPOON:
Welcome to Mostly Harmless Cutaway Ninety-Four featuring Julian, Josh, and Eric. Join us as we delve into the long awaited Series 7b premiere The Bells of Saint John. Let the banter begin!
WARNING:
This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always expect strokes of innuendo throughout.
LINKS:
Works at...
2013-04-021h 02
Doctor Who: Mostly Harmless CutawayMHC #?9 The (Non-Abominable) Snowmen5 days until The Rings of Akhaten!
DATABANKS:
Welcome to Mostly Harmless Cutaway Question Mark NINE featuring Worth. And now for something completely different...
This is a long, long, long, overdue entry from January. Originally posted via twitter, we gave Worth's piece a listen and you know what? None too shabby. Really put his finger on and expressed a few theories that had been swirling around out there concerning Clara Oswin Oswald and a bit more.
WARNING:
This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you...
2013-04-0113 min
Doctor Who: Mostly Harmless CutawayMHC #92 The Glory of Canon: An Unexpected Journey14 days until The Snowmen! PRECIOUS: Welcome to Mostly Harmless Cutaway Ninety-Two featuring an unlikely collection of hosts: Eric and Julian! This is the long awaited follow-up to MHC #36. It's been quite some time since Julian was allowed into the studio and for newer listeners you're about to find out why as we step into the madness... WARNING: This discussion may contain miscellaneous, Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS...
2012-12-1041 min
Doctor Who: Mostly Harmless CutawayMHC #?8 Cyber Testicle Cometh55 days until the 2012 Christmas Special! SEXDALEK: Welcome to Mostly Harmless Cutaway Question Mark EIGHT featuring Eric and Josh. And now for something completely different... Listen as we introduce you to an exclusive addition to the MHC feed coming this Thursday, November 1st... WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always expect strokes of innuendo throughout. LINKS: Radio...
2012-10-3009 min
Prognosis Negative Movie ReviewsMHC #?7 Cutbits: Josh Boy GeniusYou may've noticed this show is now listed on iTunes as Doctor Who: Prognosis Negative. What does that even mean? It means we're finally wearing our Doctor Who on our sleeve. Just to remind you that this podcast is closely linked to another, we're offering you this special crossover from our core feed MHC: CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Seven featuring Eric, Josh, and Steven. Confused yet? We are finally delivering something that's been talked about and requested going back to the very first year of this podcast. That's right boys and girls...
2012-10-1803 min
Doctor Who: Mostly Harmless CutawayMHC #?7 Cutbits: Josh Boy Genius67 days until the 2012 Christmas Special! CUTBITS: Welcome to Mostly Harmless Cutaway Question Mark Seven featuring Eric, Josh, and Steven. Confused yet? We are finally delivering something that's been talked about and requested going back to the very first year of this podcast. That's right boys and girls, for the first time we're delving into some very excusive MHC: Cutbits™. A taste of some of those discarded pieces of tape lying on the edit bay floor that normally never see the light of day. We really hope you enjoy this feature we've never before attempted. If well re...
2012-10-1803 min
Doctor Who: Mostly Harmless CutawayMHC #?6 My 2MTL Take on Angels85 days until the 2012 Christmas Special! CONCENTRATED: Welcome to Mostly Harmless Cutaway Question Mark Six featuring Eric! Yes, just Eric. This brief Cutaway is an editorial response or reaction to the very recent Two-minute Time Lord #282. Special thanks to Chip, the @2minutetimelord himself for putting out his fantastic podcast! WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to new & classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always expect strokes of...
2012-09-3002 min
Doctor Who: Mostly Harmless CutawayMHC #83 Asylum of the Daleks 7.14 days until Dinosaurs on a Spaceship! EGGS: Welcome to Mostly Harmless Cutaway Eighty-Three featuring Eric, Josh, Cat, and Sean! Join us as we dive into the Series 7 premiere, Asylum of the Daleks. Let the banter begin! This discussion also includes a little bit of recap on Pond Life and the AotD prequel. Special thanks to @LinkinPhoenix, @HollyGoDarkly, @TARDISTimeWarp, and @abby_queenofall for the feedback! WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain...
2012-09-041h 17
Doctor Who: Mostly Harmless CutawayMHC #82 A Tear for Caroline and Mary2 days until Asylum of the Daleks! RIP: Welcome to Mostly Harmless Cutaway Eighty-Two featuring the original Time Team: Eric, Josh, and Cat! Oh, and there's Kyle. Grab a box of tissues as we address a recent pair of significant lossess from our beloved Doctor Who family, the passings of Caroline John and Mary Tamm. As we all know, Series 7 is just around the corner and we whet our appetites with a little Pond Life. This is 'go time' folks so expect rapid fire MHC releases throughout Whotember*. WARNING: This discussion contains miscellaneous, Sherlock, Torchwood...
2012-08-3051 min
Doctor Who: Mostly Harmless CutawayMHC #74 Something, Something, Hartnell205 days until Gally 24! WIBBLY: Welcome to Mostly Harmless Cutaway Seventy-Four featuring hosts: Eric, Josh, Kyle, and Paul! This was never intended to be part of the MHC canon—it's actually the conversation that took place after the recording of MHC #73 which took place March 30, 2012. Chris Sigma (@theoodcast) isn't in this episode, but here he is standing next to that curious looking spider-web wall inside the TARDIS at the 'official' Doctor Who covention held in Cardiff March 24-25, 2012. -----> We discuss the Hartnell era and why you should love it. Other topics include: Kinda, The Time Meddler, th...
2012-07-2553 min
Doctor Who: Mostly Harmless CutawayMHC #79 The Cutaway Cheats V - The Podcast Rises210 days until Gally 24! CHEATS: Welcome to Mostly Harmless Cutaway Seventy-Nine featuring hosts: Eric, Kyle, and Christopher! As we all know: It's about time. Welcome to this very special and very rare day-on-date edition of MHC. Join us as we get up to speed on what's been going on lately in the world of Doctor Who. This is in fact Matt Smith meeting his hero Kyle at SDCC 2012 -----> Wimey is the Timey as this episode ALSO features the fifth installment of The Cutaway Cheats. You read correctly, this is not a mistake. Part 5 preceeds 3 and four...
2012-07-201h 13
Doctor Who: Mostly Harmless CutawayMHC #73 Around the Horns of Nimon II304 days until Gally 24! SOLDEED: Welcome to Mostly Harmless Cutaway Seven-Three featuring Eric, Josh, Katrina (@xanister), Kyle (@FunctionalNerd), Chris (@dubbayoo), Erik (@sjcaustenite), and Paul (@KungFuYoda)! And we have something very special to present to you today — the second edition of Around the Horns of Nimon! This is a new game we've put together to serve 2 basic functions. 1) Pass the time until new WHO returns with Series 7. 2) Give us a forum whereby we have the flexibility to present a fluid cornucopia of guests on any give week. Choose your favorite Lord weakling scum! WARNING: This discussion co...
2012-04-1849 min
Doctor Who: Mostly Harmless CutawayMHC #70 The Power of Kroll 102322 days until the next Gally 24! GALLY: Welcome to Mostly Harmless Cutaway Seven-O featuring Eric, Josh, and Erik (@sjcaustenite)! That's right folks, it's finally time to sit down for a massive helping of Robert Holmes' indelible The Power of Kroll. Yes folks, Commentaries are back! WARNING: This discussion contains miscellaneous, Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always expect strokes of innuendo throughout. LINKS:
2012-03-312h 00
Doctor Who: Mostly Harmless CutawayMHC #66 Gally 23 The Pharos Project357 days until the next Gally 24! GALLY: Welcome to Mostly Harmless Cutaway featuring Eric, Paul, Little Pete, and Nancy! Join us at Gally 23 Sunday night Lobbycon. Time is short and the end is near. Intro courtesy of Simon Fisher-Becker, Dorium Maldovar himself! What a kind-hearted fellow. WARNING: This discussion contains miscellaneous Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always expect strokes of innuendo throughout. ...
2012-02-2515 min
Doctor Who: Mostly Harmless CutawayMHC #65 Underworld [Gally 23 Edition] 15.17-20358 days until the next Gally 24! GALLY: Welcome to Mostly Harmless Cutaway featuring Eric, Josh, and a podcest cast of many! Join us at Saturday night Lobbycon at Gally 23 as we delve into the story where Louise Jameson decided she was finished with Doctor Who, Underworld! Special thanks to friend of the show Gary Russell (@twilightstreets) for helping us get the ball rolling! Intro courtesy of Yee Jee Tso, the Asian Child himself! What a stand-up guy. WARNING: This discussion contains miscellaneous Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you...
2012-02-231h 38
Doctor Who: Mostly Harmless CutawayMHC #63 The Hounds of Baskerville 2.232 days until the next Gally 23! CUMBERBATCHED: Welcome to Mostly Harmless Cutaway featuring Eric and Josh! Join us as we delve into Steven Moffat's latest offering The Hounds of Baskerville! Special thanks to Blastoise Gutiérrez (@femurmon) for this weeks feedback. Go check out our infamous Scott Pilgrim / Julian Chapman project: MHC #?? Do keep up... WARNING: This discussion contains miscellaneous Sherlock, Torchwood, new WHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms a...
2012-01-1658 min
Doctor Who: Mostly Harmless CutawayMHC #53 Let's Kill Hitler 32.81 day until The Blood Line Heil: Doctor Who — Let's Kill Hitler with Eric, Josh, Cat and Sean! Join us as delve into the not so latest ep featuring your favorite Time Team. Thank you @TheAzianChild for the cold open. Mostly Harmless thanks to Erika (@_HollyGoDarkly_), Nicola Bryant (@thenicolabryant), and Mark Cockram (@MarkCockram). WARNING: This discussion contains miscellaneous Torchwood, NüWHO, and Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is MOSTLY HARMLESS & contains EXPLICIT terms and as always exp...
2011-09-081h 13
Doctor Who: Mostly Harmless CutawayMHC #49 The Categories of Life 4.56 days until Torchwood: Immortal Sins Torchwood: Outside the government. Beyond the police. In today's Cutaway Eric, Josh, Cat, and Julian delve into the not so latest ep of Torchwood The Categories of Life. Marvel as we skillfully compare Miracle Day to the Barry Letts era of Doctor Who. Mostly Harmless thanks to Erika (@_HollyGoDarkly_), Mark (@MarkCockram) Nick (@sputuk), Elizabeth (@lizaanne42), and The Naked Scarf (@NakedScarf) for the twitter feedback. "If you wish to make an apple pie from scratch, you must first ask Rory's permission to invent the Universe." -@OzzyBaxter WARNING: This discussion...
2011-08-141h 33
Doctor Who: Mostly Harmless CutawayMHC #42 The Almost People 32.60 days until A Good Man Goes to War. 7 days for the US! THE: ...Rebel Podcast! In today's show Eric, Josh, Cat, and Sean (@tardistavern) get their Ganger on with The Almost People. But wait, there's more! Cat did her homework at we talk The Ark in Space. But wait, there's more! For those on Nipple Watch check timestamp 23:55 of the episode in question. Mostly Harmless thanks to Emma @emsray96, Carl @ccaarrll, Nick @sputuk and The Naked Scarf @NakedScarf for the twitter feedback. WARNING: This discussion contains miscellaneous NüWHO & Classic SPOILERS pertaining to Doctor W...
2011-06-041h 52
Doctor Who: Mostly Harmless CutawayMHC #37 The Impossible Astronaut 32.14 days until Day of the Moon. SPOILERS: In today's show Eric, Josh, and Cat (@fancyfembot) rip The Impossible Astronaut wide open. You have been warned. WARNING: This discussion contains miscellaneous NüWHO & Classic SPOILERS pertaining to Doctor Who. If you are 100% spoilerphobic to New & Classic epsiodes not yet seen, do not complain to us. This episode is Mostly Harmless, but as always expect possible strokes of innuendo throughout. LINKS: The Doctor / River Song timeline via @team_tardis: sleepysleepyy.tumblr.com Sci-Fi Party Line: scifipartyline.com Sci-Fi Party Line News Network: scifipartyline.net
2011-04-261h 09Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 12/19Einfluss des PHLDA1 Proteins auf die MHC Klasse I ExpressionDas PHLDA1 (pleckstrin homology-like domain family A member 1) ist ein induzierbares zytoplasmatisches Protein, das einige Motive, die für die Vermittlung von Protein-Protein Interaktionen bekannt sind, enthält. Die PHLDA1 ist stark in gutartigen melanozytären Läsionen (Naevi) exprimiert und wird während der Tumorprogression des humanen Melanoms vom Primärtumor bis hin zur Metastase herunterreguliert. Das PHLDA1 Protein scheint als ein proapoptotisches Molekül zu fungieren. Das Mechanismus ist allerdings noch nicht bekannt. In dieser Arbeit wird gezeigt, dass die 293 PHLDA1 Transfektanten zusätzlich zu einer erhöhten Apoptose Empfindlichkeit auch eine höhere MHC Klasse I Oberflächenexpress...
2010-07-1500 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 10/19Immungenetische Untersuchungen zur Assoziation von Polymorphismen im nicht-klassischen MHC-Klasse-Ib-Gen HLA-G mit der schwangerschaftsinduzierten Autoimmundermatose Pemphigoid gestationisPemphigoid gestationis ist eine seltene blasenbildende Autoimmundermatose unklarer Ätiologie, die ausschließlich im Zusammenhang mit Schwangerschaften oder schwangerschaftsassoziierten Tumoren beobachtet wird. Als Autoantigen konnte das Transmembranprotein Kollagen-Typ-XVII, ein Strukturelement der Hemidesmosomen der dermoepidermalen Junktionszone, identifiziert werden. Der selbstlimitierende Krankheitsverlauf und die hohe Rezidivneigung bei Folgeschwangerschaften deuten auf eine pathogenetische Rolle schwangerschaftsspezifischer Veränderungen endokriner sowie immunologischer Faktoren hin. Es besteht darüber hinaus eine Assoziation mit den MHC-Klasse-II-Antigenen HLA-DR3 und -DR4 bei den Patientinnen sowie mit dem väterlichen Haplotypen HLA-DR2.
HLA-G ist ein nicht-klassisches MHC-Klasse-Ib-Molekül, das hauptsächlich von den extravillösen Trophoblasten der Plazenta exprimiert wird. Es gibt z...
2009-11-1900 minTierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 04/07Untersuchungen über den Einfluss des Equiden Herpesvirus 1 auf die MHC I- und MHC II-Expression equiner ZellenAnalysis of MHC I and II presentation on Equid herpesvirus 1 infected cells
Various Alphaherpesviruses are able to interfere with MHC class I presentation by reducing surface expression of these molecules. Equid herpesvirus 1 (EHV-1) infection also results in MHC I downregulation on the respective cells, but other than the involvement of the viral UL49.5-protein, this process is not yet very well understood (Rappocciolo et al., 2003; Ambagala et al., 2004; Koppers-Lalic et al., 2005). As the in vitro non essential EHV-1 proteins UL11p and UL43p were considered as further candidate proteins for playing a role in interfering with MHC I or...
2008-07-1800 min
Journal Club Imunoterapia TumoralEdição #10: Efeitos na apresentação de antigénios via MHC classe II pelas celulas dendriticas maturas in vivoOlá, Viva.
Décima edição do podcast "Journal Club
Imunoterapia tumoral".
Apresento-vos o artigo Dendritic cell preactivation
impairs MHC class II presentation of vaccines and endogenous viral
antigens Young et al 2007 PNAS 104: 17753
Este artigo demonstra que células dendriticas no seu estado
maturo in vivo
são incapazes de induzir respostas imunológicas
específicas de um antigénio, e sobretudo que a
razão que justifica este comportamento é a
ausência de sintese das moléculas alpha e beta do
heterodimero MHC classe II após
maturação. Os autores observam que mesmo
após maturação, as células
continuam a...
2008-01-1423 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06MCMV interferiert mit der MHC-Klasse-I-AntigenpräsentationDas Zytomegalievirus der Maus (MCMV) zählt zur Familie der Herpesviridae und hat
verschiedene Strategien entwickelt, um dem Immunsystem des Wirts zu entgehen. Einer
dieser Mechanismen beeinflusst die Antigenpräsentation durch MHC-Klasse-I-Moleküle und
wird durch das virale Genprodukt von m152 vermittelt. Dieses kodiert für ein Glykoprotein
von 40 kDa Größe und wird in dieser Arbeit m152/gp40 genannt. M152/gp40 blockiert den
Transport von MHC-Klasse-I-Molekülen zur Zelloberfläche und erkennt nur Moleküle der
Maus, nicht aber des Menschen. Diese speziesspezifische Erkennung von MHC-Klasse-IMolekülen
ist bisher nur für m152/gp40 bekannt und es wurden daher in der vorl...
2002-03-1100 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 01/06Die MHC-Klasse-I-regulatorische Funktion des 48 kDa Glykoproteins des murinen CytomegalovirusCytomegaloviren, die, wie alle Herpesviren, persistente Infektionen in ihren Wirten etablieren,
haben Mechanismen entwickelt, um einer Elimination durch das Immunsystem zu entgehen. Alle
bisher untersuchten Herpesviren interferieren mit der MHC-Klasse-I-restringierten Antigenpräsentation.
Murines Cytomegalovirus verfügt neben der m152-vermittelten Retention von
MHC-Klasse-I-Molekülen im ERGIC/cis-Golgi über weitere Mechanismen, den Transport von
MHC-Klasse-I-Molekülen an die Plasmamembran zu verhindern (Thäle et al., 1995; Ziegler et al.,
1997).
In der vorliegenden Arbeit konnte das MCMV Glykoprotein gp48, welches durch das in der early
Phase der Infektion exprimierte Gen m06 kodiert wird, als weiteres MHC-Klasse-I-reaktives
Protein identifiziert werden. Zellen, die das Gen m06 st...
2000-12-0800 min
Medizin - Open Access LMU - Teil 10/22Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificityThe nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we have generated alloreactive CTL specific for exogenous, viral-derived peptide ligands. This approach allowed us to critically evaluate both the peptide- and MHC-specificity of these alloreactive T cells. Exploiting the accessibility of the H-2Ld class I molecule for exogenous peptide ligands, alloreactive CTL were generated that are specific for either murine cytomegalovirus (MCMV) or lymphocytic choriomeningitis virus (LCMV) peptides bound by Ld alloantigens. Peptide specificity was...
1993-01-0100 min
Biologie - Open Access LMU - Teil 02/02EXPRESSION OF A FUNCTIONAL CHIMERIC lg-MHC CLASS II PROTEINcomposed of the a- and ß-chains of the MHC class I1
I-E molecule fused to antibody V regions derived
from anti-human CD4 mAb MT310. Expression vectors
were constructed containing the functional,
rearranged gene segments coding for the V region
domains of the antibody H and L chains in place of
the first domains of the complete structural genes
of the I-E a- and ß-chains, respectively. Celltsr ansfected
with both hybrid genes expressed a stable
protein product on the cell surface. The chimeric
molecule exhibited the idiotype of the antibody
MT310 as shown by binding to the anti-idiotypic
mAb 20-46. A pr...
1992-01-0100 minMedizin - Open Access LMU - Teil 07/22A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytesPeptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II glycoproteins that are encoded by genes in the major histocompatibility complex, and the idiotypic / chain T-cell antigen receptor1–9. That a peptide must bind to an MHC molecule to interact with a T-cell antigen receptor is the molecular basis of the MHC restriction of antigen-recognition by T lymphocytes10,11. In such a trimolecular interaction the amino-acid sequence of the peptide must specify the contact with both receptors: agretope residues bind to the MHC receptor and epitope residues bind to the T-cell antigen receptor12,13. From a co...
1989-01-0100 minMedizin - Open Access LMU - Teil 03/22Involvement of Mhc Loci in immune responses that are not Ir-gene-controlledTwenty-nine randomly chosen, soluble antigens, many of them highly complex, were used to immunize mice of two strains, C3H and B10.RIII. Lymphnode cells from the immunized mice were restimulated in vitro with the priming antigens and the proliferative response of the cells was determined. Both strains were responders to 28 of 29 antigens. Eight antigens were then used to immunize 11 congenic strains carrying different H-2 haplotypes, and the T-cell proliferative responses of these strains were determined. Again, all the strains responded to seven of the eight antigens. These experiments were then repeated, but this time -antibodies specific for the A...
1982-01-0100 min