Shows
聊聊Sci477-人类代谢功能障碍相关脂肪肝空间多组学图谱这项研究通过单细胞转录组学和空间多组学技术，深入分析了代谢功能相关脂肪性肝病（MASLD）的病理机制。研究人员发现一种名为脂质相关巨噬细胞（LAMs）的特定免疫细胞在疾病恶化过程中显著增加，并确认MITF转录因子是调控其脂质处理能力和线粒体功能的关键。通过空间定位分析，研究揭示了这些巨噬细胞主要分布在肝小叶的近中央静脉区域，并通过HGF-MET信号轴发挥保护肝细胞、抑制凋亡的作用。此外，该研究还识别了与肝脏纤维化相关的RSPO3-LGR6等细胞间交互通路。这些发现为MASLD的精准诊断和新型药物靶点开发提供了详尽的分子图谱。References: Li Z, Luo G, Gan C, et al. Spatially resolved multi-omics of human metabolic dysfunction-associated steatotic liver disease[J]. Nature Genetics, 2025: 1-14.
2026-02-0523 minPaper Talk477-Spatial Multi-omics Atlas of Human Liver DiseaseResearchers utilized advanced single-cell and spatial multi-omics to map the cellular landscape of metabolic dysfunction-associated steatotic liver disease (MASLD) as it progresses toward more severe stages. A primary finding is the significant expansion of lipid-associated macrophages (LAMs), which are characterized by a specific phenotype driven by the MITF transcription factor. This regulatory pathway enhances fatty acid oxidation and mitochondrial function through the PGC1α–PPARγ axis, helping the liver manage lipid overload. Furthermore, the study suggests that these specialized macrophages exert a hepatoprotective effect by secreting growth factors that promote cell survival and limit tissue damage. By integrating transcriptomic and meta...
2026-02-0516 min
恰好我知道【抗衰/皮肤】皮肤暗淡皱纹增多？揭示气血不足与皮肤老化的生物学关联导语：交流微信13764470528当皮肤出现暗淡无光、皱纹早生等问题时，很可能不仅是表面问题，而是气血不足的内在信号。本期内容从中医理论与现代医学双视角，深入解析气血不足如何通过影响微循环、胶原蛋白合成及细胞营养供应，导致皮肤老化加速。我们将揭示皮肤作为健康镜子的深层意义，并提供从根源改善气血状态的科学方案，帮助您重获健康光泽的肌肤。00:02:03：气血不足与微循环障碍：中医理论中的血虚病机探析中医"气为血之帅"理论揭示气血互根关系，微循环灌注不足导致皮肤络脉失养[1]。[1] Li, S., & Zhang, Z. (2017). Traditional Chinese medicine and microcirculation. Microcirculation, 24(5), e12358.00:04:06：皮肤的信号：内在问题的外在体现与血流氧合的关系皮肤血流量降低30%即出现可见苍白，血氧饱和度
2025-11-0325 min
The Diagnostic MinuteSynopsis: Cutaneous Melanocytic Tumor with CRTC1-TRIM11 Fusion (CMTCT) (0:03:51)Feature Summary of CMTCT-- A novel pathologic entity of melanocytic origin,-- Variable positive immunostains for S100-protein, HMB45, and Melan-A.-- Diffusely positive stains for SOX10, MITF, and TRIM11-- CRTC1 & TRIM11 fusion is a signature genetic alteration.-- Seems to be a low-grade indolent tumor with malignant potential.=====Disclaimer The content of "The Diagnostic Minute" is intended for educational and training purposes only. Listeners assume full responsibility for their use of the information provided in the podcast and agree to use it at...
2025-10-2603 min
羊晚·花地·文化助力外国游客“落地即度假”！广州融创文旅城“空陆畅游礼包”重磅推出随着中马互免签证协定于2025年7月17日正式生效，近日，广州融创文旅城携手广州白云机场、中国南方航空、花都区文广旅体局及旅游协会，亮相马来西亚规模最大的年度旅游盛会——马来西亚国际旅游展，重磅推出多款专属“空陆畅游礼包”。据悉，这一战略举措不仅为马来西亚入境旅客打造了“落地即度假”的一站式体验，更将以文旅城为核心支点，赋能广州国际航空枢纽建设，推动大湾区文旅产业国际化升级，助力中马旅游合作迈入新纪元。在MITF展会上，广州融创文旅城作为推介焦点，向马来西亚游客生动展示了其网红景点矩阵，包括-6℃真冰真雪的热雪奇迹、双龙过山车、飞跃广东、《梦回岭南》国风实景秀及造浪池水世界等多元乐园体验。马来西亚国家旅游局副主席拿督杨顺兴亲临展位指导交流，高度评价了这一合作模式，称其“以创新航旅融合，激活双边旅游潜力”。展会现场，融创文旅城的沉浸式宣传吸引了众多旅客驻足，凸显了广州作为国际旅游目的地的吸引力。记者了解到，为响应免签政策红利，广州融创文旅城联合白云机场、南航及花都区文旅单位，精心设计了“空陆畅游礼包”。马来西亚籍旅客凭登机牌和护照，即可尊享文旅城旗下乐园门票最高8折、酒店餐饮及客房最高5折的专属优惠。这一福利覆盖亲子撒欢、朋友狂欢等场景，让旅客从白云机场入境后无缝衔接“嗨玩模式”。景区相关负责人表示，热雪奇迹的冰雪童话、水世界的盛夏激情以及旋转木马的童心时光，均成为礼包亮点，可确保旅客“假期镜头里全是高能瞬间”。广州融创文旅城积极发挥“小票根撬动文旅大经济”的战略智慧。基于广州白云机场运营着广州至马来西亚五个城市的密集航线，全面覆盖商务及旅游目的地，通过“航空+”生态，文旅城将登机牌转化为文旅消费入口，不仅吸引了入境客流，更带动周边酒店、餐饮等产业链。据广州市文化广电旅游局数据，上半年广州共接待入境过夜游客260.5万人次，入境文旅消费18.8亿美元，同比分别增长14.4%、16.8%。政策红利与服务优化共筑的优良入境文旅环境，正吸引越来越多境外游客前来感受“广东魅力”。花都区文广旅体局表示，融创文旅城作为区域文旅标杆，正助力广州打造“国际消费中心城市”，其冰雪经济与亲子娱乐特色，填补了大湾区国际旅游空白，预计将拉动花都文旅GDP整体增长。未来，白云机场将持续构建航旅产品矩阵，深化与广州融创文旅城的合作，为海外市场不同人群定制服务生态。融创文旅城则将作为核心引擎，通过更多国际展会曝光和创新礼包，加速广州文旅产业国际化进程。随着免签红利释放，广州融创文旅城正以“高度”定义中马文旅新篇章——不仅是游客的欢乐目的地，更是区域经济升维的战略支点。文 | 记者 刘星彤图 | 受访者提供
2025-08-2203 min
JCO Precision Oncology ConversationsJCO PO Article Insights: Germline Pathogenic Variants in Renal Cell CarcinomaIn this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: "Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening," by Dr. Kate I. Glennon et al. published on August 01, 2024, and "Incidental Pathogenic Variants in Renal Cell and Urothelial Carcinoma: Is It Time for Universal Screening?" by Dr. Salvador Jaime-Casas, et al. published on August 01, 2024. TRANSCRIPT Miki Horiguchi: Hello and welcome to JCO Precision Oncology Article Insights. I'm your host Miki Horiguchi, an ASCO Journal's Editorial Fellow. Today, I'll be providing summaries of the article titled, "Germline Susceptibility to Renal Cell...
2024-11-2709 min
From Lemons to LimoncelloEP 26 - Finding Balance and Living in the Moment: Falling in love with your life, with John FicoHave you ever wondered what it's like to be an actor? Or maybe wanted to be one? In this episode, I talk with my friend, actor and student of the human experience, John Fico about this and so much more.
John is an exceptional actor, but he’s also a truly mindful and kind human being who's mastered something we all struggle with: finding a balance between meeting our responsibilities and still loving our day-to-day existence. In this funny and candid chat, we talk about that balance, stereotypes around acting as a profession, and th...
2024-08-1157 min
ErkundungstourJ50 Der mitfühlende RetterEmotionen und Vollmacht - Jesus repräsentiert das Gute
►Dieser Beitrag mit allen Zitatangaben: https://www.erkundungstour.com/post/j50-der-mitf%C3%BChlende-retter
Kommen Sie mit zur Erkundungstour: Jede Woche eine neue Etappe zum Lesen oder Hören sowie zum Mitmachen. www.erkundungstour.com
2024-03-2607 minThe Diagnostic MinuteMini-review: Cutaneous Melanocytic Tumor With CRTC1 & TRIM 11 Translocation (03:35)Feature Summary of CMTCT-- A novel pathologic entity of melanocytic origin,-- Variable positive immunostains for S100-protein, HMB45, and Melan-A.-- Diffusely positive stains for SOX10, MITF, and TRIM11-- CRTC1 & TRIM11 fusion is a signature genetic alteration.-- Seems to be a low-grade indolent tumor with malignant potential.
2024-02-0703 min
In The Mood For California"Blossom in Every Corner: the Garden and Life of Alla”Today we’ll feel and experience the Garden of Alla followed by an interview with incredibly gifted Romy Nordlinger!
Romy is an NYC based Actor, Playwright/Screenwriter and Audiobook Narrator. Some recent TV roles include guest and co-starring roles on Bull, Manifest, FBI and Law & Order (Officer Talbor). She can be seen in numerous independent films, most recently as Agent Farrow in The Good Egg. Recently she wrapped the lead role in the soon to be released short film, The Feeling Part, which she wrote, based on her stage play of the same name. As an actor some NYC credits in...
2023-09-2941 min
A Life That's Good19. Great Music For a Greater Cause - Music in the Field'sAnd of course, that greater cause in this case is our community!
How cool is it when a group of people come together to do good things?
It's that much better when it becomes a world class event and such is the case with the Lucknow Kinsmen and Music in the Fields.
This week, marketing director for MitF's Cheryl Johnston joins us to talk about how it started and how it just seems to get bigger and stronger every year!
Music in the Fields goes in Lucknow August 24th - 26th.
2023-07-2436 min
Bitte machen Sie ein Update!Call of Duty vs Battlefiel mit GustafGabelBattlefield oder Call of Duty? Egal hauptsache Jump'n Run, oder so ähnlich... Zusammen mit Georg aka GustafGabel (mitF) vergleichen wir heute diese 2 Shooter Größen, was läuft gut was läuft schlecht, oder sind sie sich im Grunde sehr ähnlich?
Links zum Gast:
Youtube: https://www.youtube.com/channel/UCuAm6t639K3bzFyplqFbcxg
Twitch: https://www.twitch.tv/gustafgabel
Insta: https://www.instagram.com/gustafgabel/
entdecke die Capture Card von KRATOS-Gaming die THEIA 4K !
https://www.kratosgaming.de/
2022-06-131h 02
The Israel ConversationHaviv Rettig Gur on UkraineRussia's invasion of Ukraine has been the focus of our thoughts and conversations. Long time listeners know the Times of Israel's senior analyst, Haviv Rettig Gur, as a friend of the podcast who helps us make sense of complex topics. In this extra long episode, Leil and Mike talk with him about what the conflict means to Israel and the world, and what it might mean for the future. What are the lessons that we must take from what has happened so far?We start this important episode with a powerful Masa Moment from...
2022-03-141h 06
Baring It All with Call Me AdamCrystal Skillman and Bobby Cronin Return: Lessons Learned, Industry Secrets, Bullying, Sexual Harassment, King Kirby, Mary and MaxIt's so great to welcome back Crystal Skillman and Bobby Cronin, co-writer and composer of the hit audio play/podcast King Kirby. Today, Crystal & Bobby are truly Baring It All with lessons learned, industry secrets including bullying and sexual harassment, plus much more!Listen to Part 1 of our interview! We talked about Jack Kirby, Comics & the creative process of turning King Kirby from a stage play into a podcast/audio play.King Kirby tells the story of Jack Kirby, who co-created some of Marvel's most famous comic books including Captain America, X-Men, and The Avengers....
2021-08-1931 min
Springer NatureTRIM63 as a biomarker for MiT family RCCIn this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH assays can improve the accuracy and efficiency of MiTF-RCC diagnosis.
Associated article: TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma. https://www.nature.com/articles/s41379-021-00803-z
2021-08-1220 min
Baring It All with Call Me AdamBobby Cronin and Crystal Skillman: King Kirby, Broadway Podcast Network, Marvel Comics, Captain America, The Avengers, X-Men, Composer, PlaywrightMy spidey senses are tingling today because I am swinging into the world of Marvel Comics with my special guests Crystal Skillman & Bobby Cronin, whose fantastic podcast, King Kirby, is burning up the podwaves. I talk with Crystal & Bobby about their love of comics, how they adapted King Kirby (originally a play by Crystal & her husband Fred Van Lente) into a podcast & much more!King Kirby is about Jack Kirby, the most famous cartoonist you never heard of, who co-created such mega hit comics as Captain America, The Avengers & X-Men.Listen to Part 2 of ou...
2021-08-0528 min
ModPath ChatTRIM63 as a biomarker for MiT family RCCIn this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH assays can improve the accuracy and efficiency of MiTF-RCC diagnosis.Study by Mehra et al, TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma. Modern Pathology, 34, 1596-1607, 2021. https://www.nature.com/articles/s41379-021-00803-z. Hosted on Acast. See acast.com/privacy for more information.
2021-08-0320 min
ModPath ChatTRIM63 as a biomarker for MiT family RCCIn this episode Dr. Rohit Mehra of University of Michigan discusses the utility of TRIM63 as a diagnostic marker to distinguish MiTF-RCC from other renal tumor subtypes with overlapping morphology. In combination with TFE3/TFEB FISH, TRIM63 RNA-ISH assays can improve the accuracy and efficiency of MiTF-RCC diagnosis.Study by Mehra et al, TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma. Modern Pathology, 34, 1596-1607, 2021. https://www.nature.com/articles/s41379-021-00803-z.
2021-08-0320 min
Musical Theatre Radio presents "Be Our Guest"Be Our Guest with Bobby CroninBobby Cronin is an award-winning composer/writer for theatre, short film, web, dance, and more. His projects include: Mary & Max [based on the clyamation film] with bookwriter Crystal Skillman which had its World Premiere at Theatre Calgary in the fall of 2018 and will have its European Premiere at Austria’s Theatre Linz in 2019, won the 2018 MUT Critics Award in Germany, Pace New Musicals 2018, SigWorks Finalist 2018; ‘Til Death Do Us Part (World Premiere 2020, 2018-2020 SDSU New Works Award; 2017 SigWorks Finalist; 2016 Overtures Series directed by Kent Nicholson) with bookwriter Caroline Prugh; a handful of songs in Off-Bway’s Camp Morning Wood; Till S...
2021-05-301h 03
hey you know itHYKI476: Free Clownference Call
We are elated to have theatre artists and activists Rachel Weekley and Ashley Lauren Rogers with us to talk about creating good theatre, staging fights, representation, mime, live shows in the time of quarantine and what we’re watching. Please enjoy.
Our Guests
Ashley Lauren Rogers, award winning writer and trans rights activist. Recently a Trans Theatre Lab fellow 2019, the Literary Director for Step1 Theatre Project, artist in residence at Middlesex County Vocational Technical School 2018-2019. Works performed at Dixon Place, MITF, the Brick, Joe’s Pub and ot...
2020-07-201h 00
OokTown - The Ukulele PodcastEp. 89: Nice-olationGuests: Sarah Goodroad, Mary Agnes Krell, Ben Hassenger
Hosts: Stuart Yoshida, Doug Brown
It’s May 2020 in the year of the pandemic, and we’re still hunkered down trying to figure out how to do things like: having virtual ukulele strum along and festivals! And we’ve got an all-star panel of guests with Sarah Goodroad of the Boulder Ukulele Group, Mary Agnes Krell of GNUF, and Ben Hassenger, the self-proclaimed Ukulele Ambassador of Michigan. Now, grab your favorite self-isolation beverage, sit back, and join us… on the OokTown Podcast.
Support us on Patreon: https://www.patreon.com/ooktown
Make a donati...
2020-06-011h 33
LocalTheatreNY Theatre & Entertainment PodcastLTNY Ep. 16 Interview with MITF's John ChattertonJohn Chatterton is the founder and executive director of the Midtown InternationalTTheatre Festival. This year, they have slightly changed their format, added new things, and removed certain fees.In this podcast interview, he discusses some of these changes. M Chatterton can be reached at john.chatterton@gmail.com and midtownfestival@gmail.com or at their website: http://www.midtownfestival.org/
2015-12-1130 min
In The Country with Dave WoodsInterview with James CameronJAMES CAMERON is the front man for the James Cameron Band - an up & coming Country band from South Western Ontario. After joining together in 2011, James and the band have found themselves in the midst of the Canadian country music scene. Soon after, James and the crew took the stage at Music in the Fields in Lucknow, Ontario. As voted by the public, they found themselves coming out on top of an online poll called the Sepoy Saloon Showdown and receiving the invitation to play on the Saturday of this two day country festival, which headlined the likes of Doc W...
2013-07-0527 min
Interview with James CameronJAMES CAMERON is the front man for the James Cameron Band - an up & coming Country band from South Western Ontario. After joining together in 2011, James and the band have found themselves in the midst of the Canadian country music scene. Soon after, James and the crew took the stage at Music in the Fields in Lucknow, Ontario. As voted by the public, they found themselves coming out on top of an online poll called the Sepoy Saloon Showdown and receiving the invitation to play on the Saturday of this two day country festival, which headlined the likes of Doc W...
2013-07-0528 min
Medizin - Open Access LMU - Teil 21/22Spectrum of novel mutations found in Waardenburg syndrome types 1 and 2: implications for molecular genetic diagnosticsObjectives: Till date, mutations in the genes PAX3 and MITF have been described in Waardenburg syndrome (WS), which is clinically characterised by congenital hearing loss and pigmentation anomalies. Our study intended to determine the frequency of mutations and deletions in these genes, to assess the clinical phenotype in detail and to identify rational priorities for molecular genetic diagnostics procedures. Design: Prospective analysis. Patients: 19 Caucasian patients with typical features of WS underwent stepwise investigation of PAX3 and MITF. When point mutations and small insertions/deletions were excluded by direct sequencing, copy number analysis by multiplex ligation-dependent probe amplification was performed to...
2013-03-1800 min
Broadway Bullet: Theatre from Broadway, Off-Broadway and beyond.Vol 414 - Oct. 7, 2010 - Golden Boy of the Blue Ridge & moreIn this episode: The Amoralists are presenting Adam Rapp's first play, GHOSTS IN THE COTTONWOOD, in a re-written version. Actors Matt Pilieci and Nick Lawson discuss the play, their company, and why gambling in Vegas isn't the best way to fund a theatre. The York Shakespeare Company is one of New Yorks most active presenters of the Bard's work. Director Seth Duerr and Actress Jenn Remke stopped by to discuss their current rep presentations of MACBETH and RICHARD II as well as a great discussion on philosophies of approaching the classics and their ideas of some of the best training...
2010-10-0559 min