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Vector SignalsAI for Culex Mosquito Identification using Wing Patterns (July 2025)Detailed Briefing Document: Application of Wing Interference Patterns (WIPs) and Deep Learning (DL) for Culex spp. ClassificationApplication of wings interferential patterns (WIPs) and deep learning (DL) to classify some Culex. spp (Culicidae) of medical or veterinary importanceArnaud Cannet, Camille Simon Chane, Aymeric Histace, Mohammad Akhoundi, Olivier Romain, Pierre Jacob, Darian Sereno, Marc Souchaud, Philippe Bousses & Denis Sereno Scientific Reports volume 15, Article number: 21548 (2025)Source: https://doi.org/10.1038/s41598-025-08667-yReceived - 28 November 2024 | Accepted - 23 June 2025 | Published - 01 July 2025This briefing document reviews a...2025-07-0116 minVector SignalsBattle of the Mosquitoes: Genetic War on Malaria (June 2025)Detailed Briefing Document: The Battle of the Mosquitoes - A New Approach to Malaria ControlSource: Adepoju, P. Battle of the mosquitoes. Nat Med 31, 1722–1726 (2025). https://doi.org/10.1038/s41591-025-03753-0Dates: Published - 11 June 2025 | Issue Date - June 2025I. Executive SummaryThis briefing document summarizes the key themes and facts from the provided source, "Battle of the Mosquitoes," detailing the innovative approach of using genetically modified mosquitoes to combat malaria, particularly in urban environments. The core of this strategy, pioneered by Oxitec, involves releasing male Anopheles stephensi mosquitoes en...2025-06-2716 minVector SignalsGreenland Mosquito Virome: Arctic Aedes Uniqueness (May 2025)Briefing Document: Unique Virome of Arctic Mosquitoes in GreenlandSource: https://doi.org/10.1038/s41598-025-01086-z: "Metagenomic analysis of mosquitoes from Kangerlussuaq, Greenland reveals a unique virome" by Schilling, Jagdev, Thomas, & Johnson (2025). Date: Received - 17 January 2025 | Accepted - 02 May 2025 | Published - 17 May 2025Subject: Metagenomic analysis of mosquito viromes in Kangerlussuaq, Greenland and implications in the context of climate change.Summary: This study provides the first metagenomic analysis of the virome of two prevalent Arctic mosquito species, Aedes impiger and Aedes nigripes, sampled near Kangerlussuaq, Greenland. The research e...2025-05-3020 minVector SignalsNovel Quinolones Counteract Insecticide Resistance in Malaria Vectors (May 2025)BRIEFING DOCUMENT: Novel Approach to Malaria Control Targeting Mosquito-Stage Plasmodium ParasitesDate: Received - 29 March 2025 | Accepted - 17 April 2025 | Published - 21 May 2025Source: Excerpts from "In vivo screen of Plasmodium targets for mosquito-based malaria control" by Probst et al. (Published online xx xx xxxx, Nature) https://doi.org/10.1038/s41586-025-09039-2Subject: Development and testing of novel antiparasitic compounds for incorporation into mosquito bed nets to combat insecticide resistance and reduce malaria transmission.Summary:This research presents a promising new strategy for malaria control by targeting the Plasmodium falciparum...2025-05-3024 minVector SignalsBlocking Malaria Transmission with PfPIMMS43 Nanobodies (April 2025)Briefing Document: Nanobody-Mediated Blocking of Malaria Transmission Targeting PfPIMMS43Source: Excerpts from "s42003-025-08033-8.pdf" (A Nature Portfolio journal; https://doi.org/10.1038/s42003-025-08033-8) Authors: Chiamaka Valerie Ukegbu, et al. Date: Received - 04 December 2024 | Accepted - 02 April 2025 | Published - 30 April 2025Executive Summary:This study explores a novel strategy to block malaria transmission by targeting the Plasmodium falciparum protein PfPIMMS43 using single-domain VHH antibodies, also known as nanobodies. PfPIMMS43 is a critical surface protein for the parasite's development within the mosquito, specifically during the transition from ookinete to o...2025-05-0312 minVector SignalsNanofiber Encapsulation of Pseudomonas for Sustained Mosquito Larvicide Release (April 2025)Briefing Document: Nanofiber Encapsulation of Pseudomonas aeruginosa for Sustained Mosquito Larvicide ReleaseDate: Received - 13 December 2024 | Accepted - 04 April 2025 | Published - 21 April 2025 Source: Excerpts from "Nanofiber encapsulation of Pseudomonas aeruginosa for the sustained release of mosquito larvicides" https://doi.org/10.1038/s41598-025-97400-w1. Executive Summary:This study investigates a novel approach for mosquito vector control using nanofiber encapsulation of the bacterium Pseudomonas aeruginosa. The research addresses the inadequacy of current vector control strategies in eliminating mosquito-borne diseases by developing a method for the sustained release of bacterial larvicides...2025-04-2113 minVector SignalsPredicting Aedes Albopictus Spread in Europe via Climate and Population (April 2025)Population Dependent Diffusion Model for Aedes Albopictus Spread in EuropeSource: Barman et al., "A climate and population dependent diffusion model forecasts the spread of Aedes Albopictus mosquitoes in Europe," Nature Portfolio journal, 2025, https://doi.org/10.1038/s43247-025-02199-zDate: Received - 25 November 2024 | Accepted - 07 March 2025 | Published - 09 April 2025Key Themes and Important Ideas/Facts:This paper presents a novel spatio-temporal diffusion model that accurately forecasts the spread of Aedes albopictus mosquitoes in Europe by simultaneously considering climate suitability and human population factors. Ae. albopictus is a...2025-04-1212 minVector SignalsMalaria Transmission: Parasite and Vector Circadian Clock Coordination (April 2025)Parasite and Vector Circadian Clocks Mediate Efficient Malaria TransmissionSource: Bento et al., "Parasite and vector circadian clocks mediate efficient malaria transmission," Nature Microbiology, Published online 31 March 2025, https://doi.org/10.1038/s41564-025-01949-1Date: Received: 03 September 2024 | Accepted: 26 March 2025 | Published: 04 April 2025Key Themes:This study uncovers a critical tripartite relationship between the Anopheles mosquito vector, the Plasmodium malaria parasite, and the mammalian host, highlighting the significant role of their respective circadian clocks in mediating efficient malaria transmission. The research demonstrates that both the mosquito salivary glands and the resident sporozoite parasite...2025-04-0416 minVector SignalsRadiation Induces Alternative Splicing in Aedes aegypti (March 2025)Briefing Document: Radiation-Induced Alternative Splicing in Aedes aegypti MosquitoesSource: Bendzus-Mendoza, H., Rodriguez, A., Debnath, T., Bailey, C. D., Luker, H. A., & Hansen, I. A. (2025). Radiation exposure induces genome-wide alternative splicing events in Aedes aegypti mosquitoes. Scientific Reports, 15, 5885.Date of Publication: Received - 19 June 2024 | Accepted - 14 March 2025 | Published - 24 March 2025Key Themes and Important Ideas/Facts:This study investigates the impact of ionizing radiation on alternative splicing events (ASEs) in male Aedes aegypti mosquitoes, a crucial aspect for improving the sterile insect technique (SIT). The researchers compared RNA sequencing data from...2025-03-2420 minVector SignalsMosquito Prefoldin Targeting Blocks Plasmodium Transmission (March 2025)Briefing Document: Targeting the Mosquito Prefoldin–Chaperonin Complex to Block Plasmodium TransmissionCitation: Dong, Y., Kang, S., Sandiford, S.L. et al. Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission. Nat Microbiol (2025). https://doi.org/10.1038/s41564-025-01947-3Date: Received - 22 November 2024 | Accepted - 27 January 2025 | Published - 06 March 2025Overview:This study investigates the role of the conserved Anopheles mosquito prefoldin (PFDN)–chaperonin (CCT/TRiC) system as a potential target for blocking the transmission of multiple Plasmodium species. The researchers demonstrate that disrupting this protein folding complex in mosqui...2025-03-0719 minVector SignalsEngineered Bacteria Combat Concurrent Malaria and Arbovirus Transmission (March 2025)Briefing Document: Engineered Symbionts for Concurrent Malaria and Arbovirus Transmission ControlCitation: Hu, W., Gao, H., Cui, C. et al. Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission. Nat Commun 16, 2104 (2025). https://doi.org/10.1038/s41467-025-57343-2Dates: Received - 27 July 2024 | Accepted - 19 February 2025 | Published - 01 March 2025Prepared for: Saleh LabExecutive Summary:This research presents a novel paratransgenesis strategy utilizing engineered symbiotic bacteria (Serratia AS1) in mosquitoes to simultaneously combat the transmission of malaria parasites (transmitted by Anopheles mosquitoes) and arboviruses like dengue and...2025-03-0222 minVector SignalsMosquito Viral Tolerance Enhanced by Prolonged Heat Exposure (February 2025)Briefing Document: Heat Exposure and Mosquito-Virus InteractionSource: Perdomo, H. D., Khorramnejad, A., Cham, N. M., Kropf, A., Sogliani, D., & Bonizzoni, M. (2025). Prolonged exposure to heat enhances mosquito tolerance to viral infection. Communications Biology, 8(1), 761. https://doi.org/10.1038/s42003-025-07617-8Dates: Received - 27 September 2024 | Accepted - 28 January 2025 | Published - 04 February 2025Prepared for: Saleh LabExecutive Summary:This study investigates the impact of increased environmental temperature on the interaction between the mosquito species Aedes albopictus and the cell fusing agent virus (CFAV), an insect-specific virus. The...2025-02-0415 minVector SignalsBunyavirus NSm: Key to Transmission Between Vertebrates and Mosquitoes (January 2025)Briefing Document: NSm Protein's Critical Role in Bunyavirus TransmissionCitation: Terhzaz, S., Kerrigan, D., Almire, F. et al. NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. Nat Commun 16, 1214 (2025). https://doi.org/10.1038/s41467-024-54809-7Date: Received - 03 May 2024 | Accepted - 21 November 2024 | Published - 31 January 2025Prepared for: Saleh LabKey Themes:NSm as a Unique Feature of Vector-Borne Bunyaviruses: The study establishes a strong correlation between the presence of the non-structural protein NSm and the ability of bunyaviruses to be transmitted by arthropod...2025-02-0119 minVector SignalsZika Virus Alters Human Skin to Attract Mosquito Vectors (January 2025)Detailed Briefing Document: Zika Virus Modulation of Human Fibroblasts Enhances Transmission SuccessSource: Mozūraitis, R., Cirksena, K., Raftari, M., et al. (2025). Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting. Communications Biology, 8(1), 754. https://doi.org/10.1038/s42003-025-07543-9Date of Briefing: Received - 02 July 2024 | Accepted - 14 January 2025 | Published - 30 January 20251. Executive Summary:This study investigates how Zika virus (ZIKV) infection of human dermal fibroblasts alters the release of volatile organic compounds (VOCs) and how these changes impact the host-seeking and feeding behavior of its m...2025-01-3019 minVector SignalsMosquito Hsf1-sHsp Cascade: A Pan-Antiviral Defense (January 2025)Briefing Document: Pan-Antiviral Activity of the Hsf1-sHsp Cascade in Mosquito CellsSource: Qu, J., Schinkel, M., Chiggiato, L., Machado, S. R., Overheul, G. J., Miesen, P., & van Rij, R. P. (2025). The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells. Nature Communications Biology, 8(1), 74. https://doi.org/10.1038/s42003-024-07435-4Date: Received - 05 July 2023 | Accepted - 20 December 2024 | Published - 25 January 20251. Executive Summary:This research paper investigates the antiviral immune responses in Aedes aegypti mosquitoes, a primary vector for several arboviruses. Through multi-omics data integration, the study identifies a...2025-01-2512 minVector SignalsToxic Seminal Proteins Reduce Female Insect Lifespan (January 2025)Briefing Document: "Recombinant venom proteins in insect seminal fluid reduce female lifespan"Source: Article "Recombinant venom proteins in insect seminal fluid reduce female lifespan" by Samuel J. Beach & Maciej Maselko, published in Nature Communications (DOI: 10.1038/s41467-024-54863-1).Date: Current date (based on when the briefing document is created).Prepared for: [Intended Audience - e.g., Pest Management Stakeholders, Research Community, Regulatory Bodies]Executive Summary:This research presents a novel genetic biocontrol technology termed the "toxic male technique" (TMT). The study demonstrates, using Drosophila melanogaster as a model...2025-01-0721 minVector SignalsPredicting Infectious Disease Outbreaks with AHP and Transfer Learning (December 2024)Briefing Document: Leveraging AHP and Transfer Learning for Infectious Disease Outbreak PredictionDates: Received - 10 August 2024 | Accepted - 26 November 2024 | Published - 31 December 2024 Citation: Abdallah, R., Abdelgaber, S. & Sayed, H.A. Leveraging AHP and transfer learning in machine learning for improved prediction of infectious disease outbreaks. Sci Rep 14, 32163 (2024). https://doi.org/10.1038/s41598-024-81367-1 Keywords: Infectious diseases, AHP, Transfer learning, Risk factors, Machine learning, Dengue, Chikungunya, Zika, Outbreak predictionExecutive Summary:This study investigates the application of advanced machine learning techniques, specifically an ensemble model integrating Random Forest...2024-12-3111 minVector SignalsOntario West Nile Virus: Mosquitoes, Humans, and Risk Factors (Nature, December 2024)Briefing Document: Spatial and Temporal Analysis of West Nile Virus Infection in Ontario, Canada (2003-2022)Citation: Talbot, B., Ludwig, A., O’Brien, S.F. et al. Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data. Sci Rep 14, 31343 (2024). https://doi.org/10.1038/s41598-024-82739-3Dates: Received - 09 July 2024 | Accepted - 09 December 2024 | Published - 28 December 2024Prepared for: Saleh LabExecutive Summary:This study analyzed over two decades of data from Ontario, Canada, to understand fa...2024-12-2916 minVector SignalsExplainable Deep Learning for Molecular Discovery (December 2024)Briefing Document: Explainable Deep Learning for Molecular DiscoveryCitation: Wong, F., Omori, S., Li, A. et al. An explainable deep learning platform for molecular discovery. Nat Protoc (2024). https://doi.org/10.1038/s41596-024-01084-x Dates: Received - 11 March 2024 | Accepted - 26 September 2024 | Published - 09 December 2024Source: Excerpts from "An explainable deep learning protocol for de novo molecular discovery" (s41596-024-01084-x.pdf)Executive SummaryThis briefing document summarizes a research protocol for leveraging explainable deep learning (DL) to accelerate the discovery of novel molecules with desired properties, particularly focusing on antibiotic discovery...2024-12-0819 minVector SignalsMosquito Salivary Protein Structure Relevant to Pathogen Transmission (February 2023)Briefing Document: Native Structure of Mosquito Salivary Protein Uncovers Domains Relevant to Pathogen TransmissionDates: Received - 04 October 2022 | Accepted - 07 February 2023 | Published - 17 February 2023 Source: Liu, S., Xia, X., Calvo, E., & Zhou, Z. H. (2023). Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. Nature Communications, 14(1), 1-20. https://doi.org/10.1038/s41467-023-36577-yExecutive Summary:This study, published in Nature Communications, presents the first native structure of the Salivary Gland Surface protein 1 (SGS1) from the Aedes aegypti mosquito, a key vector for numerous human pathogens. Utilizing cryo-electron microscopy (cryo-EM...2023-02-1823 min