Shows
英语每日一听 | 每天少于5分钟第2644期: How the Brain Cleans Itself(2)Beta-amyloids are substances linked to problems in the brain including Alzheimer’s disease. When scientists injected mice with beta-amyloids, the substance left the brain faster when the animals were sleeping. β-淀粉样蛋白是与包括阿尔茨海默氏病在内的大脑问题有关的物质。 当科学家向小鼠注射β淀粉样蛋白时，该物质在动物睡觉时会更快地离开大脑。 It is not clear exactly how the system works. However, some research has shown that the movement of blood vessels might help move the waste-clearing fluid where it needs to go. 目前尚不清楚系统如何工作。 但是，一些研究表明，血管的运动可能有助于将废水清除液移动到需要的地方。 Finding the system in humans is not easy. Regular MRI scans can show some of the fluid-filled channels. But Piantino said the scans do not show their purpose. 在人类中找到系统并不容易。 常规的MRI扫描可以显示一些充满流体的通道。 但是Piantino说，扫描没有显示出其目的。 To find out more, his team at Oregon Health & Science University injected a substance called a tracer into five patients. The tracer “lit up” during MRI scans. Twenty-four to 48 hours later, the tracer material was seen moving through the brain using the channels as in the earlier research on mice. 为了了解更多信息，他在俄勒冈州健康与科...2025-04-2903 min
Audio research newsMaiken Nedergaard's power of disruptionThe award-winning researcher’s discoveries have changed the way we think about the brain; that’s exactly what her critics dislike.2024-03-2825 min
KYTOS BiologyCuring Dementia - Examining The Role of our Glymphatic SystemThe glymphatic system works as a waste-carrying drainage system which removes unwanted materials from the brain. It was identified as a system in 2013 by Danish neuroscientist Maiken Nedergaard. He used the term glymphatic because the system works in a similar way to the lymphatic system but it is managed by the glial cells of the brain. There are still many unanswered questions about the role of the glymphatic system and how it may be harnessed to alleviate diseases like Parkinsons and Alzheimer’s. New drugs could be developed to increase the rate of CSF flow during sleep, which would he...2023-07-0413 min
Innate Ability & HealthBrain Detox FastingFasting Improves Brain & Neurological Detox! A study published in Science in October 2013 entitled “Sleep Drives Metabolite Clearance from the Adult Brain” found that we need to sleep specifically so that the brain can focus on a built-in detox that happens each night. Lead study author Dr. Maiken Nedergaard summarizes in a statement: “the restorative nature of sleep appears to be the result of the active clearance of the by-products of neural activity that accumulate during wakefulness.”The study states:...the restorative function of sleep may be a consequence of the enhanced removal of...2022-10-0929 min
The Alzheimer’s Solution Revolution PodcastBrain Detoxification—Part 1—The Role of the Blood Brain Barrier and The Glymphatic SystemSummary Hello and welcome to episode #16! Today I’ll be describing an elemental aspect in maintaining a healthy brain as you age and preventing the cognitive decline that is associated with unhealthy aging and the risk for Alzheimer’s disease as you age—brain detoxification. Because brain detoxification mechanisms are a very complex review, I will provide it in three parts–this episode and the next two. Now, most people that are oriented toward health and wellness strategies know that a good detox for their bo...2022-08-0945 min
Brain Ponderings podcast with Mark MattsonPondering the Brain’s Plumbing with Maiken NedergaardThere are as many astrocytes in the human brain as there are neurons, but the functions of astrocytes in brain function, health, and disease are unclear. Professor Maiken Nedergaard of the University of Rochester and the University of Copenhagen describes recent discoveries that are revealing roles of astrocytes in processes such as learning and memory and how abnormalities in astrocytes may contribute to diseases such as Alzheimer’s disease and mental disorders. About 10 years ago Nedergaard discovered that astrocytes control the movement of fluids throughout the brain in a system she has dubbed the brain’s “glymphatic system”. An important...2022-07-1556 min
Det store perspektivSøvn: Hvad sker der med hjernen, mens vi sover?Sæson 2: Velkommen til en ny sæson af ’Det store perspektiv,’ denne gang med fokus på sundhedsforskningens seneste landvindinger. I denne første episode får Bo Elkjær besøg af Maiken Nedergaard, der er hjerneforsker og ekspert i søvn. Vi sover en tredjedel af vores liv. Men det er ikke spild af tid. Maiken Nedergaard forsker i, hvad der sker med hjernen, når man sover og hvorfor hjernen ikke kan undvære søvn. I løbet af samtalen skal vi blandt andet høre om, hvordan fluer kan få alzheimers hvis man limer deres snude fast o...2022-06-2838 min
How to Be Awesome at Your Job494: How to Train Your Brain for Maximum Growth with Dr. Tara SwartDr. Tara Swart explains the science behind neuroplasticity and how to train your brain to brave any challenge. — YOU'LL LEARN — 1) How to use neuroscience to break out of your comfort zone. 2) The six approaches to problem solving. 3) Simple tricks to turn around terrible work days. Subscribe or visit AwesomeAtYourJob.com/ep494 for clickable versions of the links below. — ABOUT TARA — Dr. Tara Swart is a neuroscientist, medical doctor, leadership coach, and award-winning and bestselling author. She works with lead...2019-09-2543 min
The Archive of Awesome494: How to Train Your Brain for Maximum Growth with Dr. Tara SwartDr. Tara Swart explains the science behind neuroplasticity and how to train your brain to brave any challenge. You'll Learn: How to use neuroscience to break out of your comfort zone The six approaches to problem solving Simple tricks to turn around terrible work days About Tara: Dr. Tara Swart is a neuroscientist, medical doctor, leadership coach, and award-winning and bestselling author. She works with leaders all over the world to help them achieve mental resilience and peak brain performance, improve their ability to manage stress, regulate emotions, and re...2019-09-2545 min
How to Be Awesome at Your Job494: How to Train Your Brain for Maximum Growth with Dr. Tara SwartDr. Tara Swart explains the science behind neuroplasticity and how to train your brain to brave any challenge. You'll Learn: How to use neuroscience to break out of your comfort zone The six approaches to problem solving Simple tricks to turn around terrible work days About Tara: Dr. Tara Swart is a neuroscientist, medical doctor, leadership coach, and award-winning and bestselling author. She works with leaders all over the world to help them achieve mental resilience and peak brain performance, improve their ability to manage stress, regulate emotions, and retain information. She is a senior lecturer at MIT Sloan School of...2019-09-2544 min
How to Be Awesome at Your Job494: How to Train Your Brain for Maximum Growth with Dr. Tara SwartDr. Tara Swart explains the science behind neuroplasticity and how to train your brain to brave any challenge. — YOU'LL LEARN — 1) How to use neuroscience to break out of your comfort zone. 2) The six approaches to problem solving. 3) Simple tricks to turn around terrible work days. Subscribe or visit AwesomeAtYourJob.com/ep494 for clickable versions of the links below. — ABOUT TARA — Dr. Tara Swart is a neuroscientist, medical doctor, leadership coach, and award-winning and bestselling author. She works with leaders all over the world to help them achieve mental resilience and peak brain performance, improve their ability to manage stress...2019-09-2545 min
七味とーがラジオ18: 脳の老廃物と深い睡眠に関する論文を読んだep.18
00:00 - 脳の老廃物と深い睡眠に関する論文を読んだ
脳の老廃物と深い睡眠
「脳の老廃物」を除去するには、深い睡眠が必須だった：研究結果｜WIRED.jp
Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia | Science Advances 27 Feb 2019
メモ
脳脊髄液(CSF)の脳への流入は睡眠中の方が多い
アクアポリン4 AQP4 水チャンネル アストロサイト（グリア細胞）の血管側末端
Glymphatic system グリンパティク系（グリンファティック系）
脳のリンパ系、老廃物の除去
ロチェスター大学医療センターの神経科学者 マイケン・ネーデルガード（Maiken Nedergaard）氏
マウスを使った研究
６種類の麻酔 K/X, ISO + dex, pentobarbital, Averting,α-Chlor, ISO
K/XとISO + dex麻酔下では脳脊髄液のトレーサーが脳内で増加
脳波のデルタ波成分と老廃物
脳波のデルタ波：深い睡眠中にでてくる脳波の低周波成分
デルタ波（δ波）：1-4Hzのゆっくりとした神経活動同期から生じる
脳脊髄液トレーサーの流入量とデルタ波に高い相関関係（ R^2=0.86）
心拍と老廃物
心拍数が下がるほど 脳脊髄液トレーサーの流入量は増加
思ったこと
グリア細胞＋リンパ系＝グリンパティック系！という新しい概念を知ることができてよかった
麻酔（てきとう）
K/X = Ketamin: NMDAR 阻害剤 + Xylazin:α2-アドレナリン受容体作動剤
ISO = Isoflurane: GABA-A Cl受容体のアロステリック調整子、NMDAR, K_SP, HCN作動剤
dex = Dexmedetomidine: Xylazinより強いα2-アドレナリン受容体作動剤
α-Chlor: α-Chloralose: GABA-A Cl受容体のアロステリック調整子
Pentobarbital:GABA-A Cl受容体のアロステリック調整子
Avertin GABA-A・グリシンR作動剤、ドーパミン作動性、5-HT、オピオイド、ムスカリン、アドレナリン受容体調整子
以下、少し古い記事で、脳内の老廃物除去が発見されたころの話し
リンパ管による脳内の老廃物除去 | Nature ダイジェスト | Nature Research 2018-08-09
第61回 脳の掃除は夜勤体制 2016年10月27日 -【連載】睡眠の都市伝説を斬る | ナショナルジオグラフィック日本版サイト
脳の自浄システムが明らかに | ナショナルジオグラフィック日本版サイト - 2012.08.17
Twitterでこのエピソードについてつぶやく
ご意見・ご感想は ハッシュタグ #七味とーがラジオ または #7miradio か
専用フォームでいつでも受け付けています。2019-03-2614 min
IDA PodcastSov GodtIDA podcast sætter denne gang spotlight på søvn og på søvnforskningen
anno 2017. For hvorfor er det, at vi bliver søvnige? Evolutionen tvinger os mennesker til at sove en tredjedel af vores liv - liggende horisontalt og paralyserede. Og det er der gode grunde til. I episoden undersøger vi søvnstadier, drømme, hjernens rensemekanismer og fremtidens søvnteknologier. Vi tager dig også med ned på et taktisk niveau og stiller spørgsmålet: Hvad kan man gøre for at sove bedre? Og er det muligt at optimere sin søvn?
Medvirkende:
Poul Jennum, professor i klinisk neurof...2017-03-2730 min