Shows
The Real World Perspective with Manfred Stapff, MD, PHDStrengthening the Mind: Yoga-Based Resilience in the Age of MisinformationA stronger mind is essential in a world overflowing with noise, distortion, and digital pressure. In this episode, Dr. Manfred Stapff sits down with Ishan Shivanand, founder of Yoga of Immortals, to explore how yoga-based resilience can help us think clearly, evaluate truth, and stay grounded. Ishan reflects on how life in a monastery and later as a mental health researcher shaped his understanding of truth and perception. He explains how yoga helps calm instinctive reactions, creating the space to question, reflect, and resist emotional manipulation. They draw clear parallels between Western science and Eastern phi...
2025-12-0921 minThe Real World Perspective with Manfred Stapff, MD, PHDThe Power of Giving Life: Inside the World of Organ and Stem Cell TransplantsGiving life is one of the most powerful gifts we can offer. In this episode, Dr. Manfred Stapff brings together remarkable stories of courage, generosity, and science in action. With both donors and recipients at the table, this conversation goes beyond medicine. It captures what it truly means to save and share life. Dr. Manfred speaks with stem cell donor Mat McConnon, his friend Kyle Kramer who inspired him to join the bone marrow registry, and Charles Walker, a liver transplant recipient who was given a second chance at life thanks to Kyle Walker's living donation. Together...
2025-11-2734 minThe Real World Perspective with Manfred Stapff, MD, PHDWhat Science Reveals About Rising Cancer RatesAdvances in medicine have saved millions of lives, yet cancer remains one of humanity's most persistent challenges. In this episode, Dr. Manfred Stapff takes a balanced look at why global cancer rates are rising and what the data truly tell us. Dr. Manfred explains that while cancer numbers have nearly doubled in the past 30 years, much of this reflects longer life expectancy and population growth, not a sudden surge in disease. Still, he points to emerging patterns such as the rise in early-onset cancers, particularly among women under 50, and explores how lifestyle, environment, and genetics intersect in th...
2025-11-1112 min
Floyd Memorial Library PodcastEpisode 189 with Manfred Stapff MD, PhD, Physician, Researcher, and Author of Real-World Evidence UnveiledToday on the podcast, I’m joined by Dr. Manfred Stapff, physician, researcher, and author of Real-World Evidence Unveiled.Born and raised in Germany, Dr. Manfred Stapff’s career has taken him from serving as a flight surgeon in the German Air Force to working with major pharmaceutical companies like Merck and Forest Laboratories, and later as Chief Medical Officer at TriNetX, where he helped shape how real-world data is used in modern medicine.Now based in Greenport, New York, Dr. Stapff continues to advise healthcare organizations and pharmaceutical companies through his firm, Candid-Advisory Inc., and...
2025-10-311h 42The Real World Perspective with Manfred Stapff, MD, PHDThe Hidden Science Behind Time Change: Does It Really Matter?Every year, millions of people adjust their clocks, but what does this one-hour shift really mean for our bodies, minds, and daily lives? In this episode, Dr. Manfred Stapff offers a grounded, science-based look at the impact of daylight saving time and why it continues to spark debate. Dr. Manfred traces the origins of daylight saving time back to World War I and explains how its purpose has evolved in modern society. He explores what current research reveals about its effects on energy use, productivity, and health drawing from real-world data on more than 170,000 patients. Bey...
2025-10-3113 minThe Real World Perspective with Manfred Stapff, MD, PHDUncovering the Truth: Acetaminophen Use in Pregnancy and Autism RiskCan a common pain reliever hold hidden risks for unborn children? In this episode, Dr. Manfred Stapff tackles one of medicine's most debated questions, whether acetaminophen use during pregnancy could influence autism risk. Dr. Manfred explores the rise in autism diagnoses, explaining how shifting definitions and improved awareness shape the numbers. He then analyzes key studies, from the Boston Birth Cohort to Sweden's national registry, revealing why research outcomes differ. While data show mixed findings, acetaminophen remains one of the safest treatments for pain and fever in pregnancy when used responsibly. Sometimes, the greater risk l...
2025-10-1441 min
Life Sciences DNA PodcastImproving Drug Development with Real-World DataManfred Stapff, founder and principal of Candid Advisory, sits down with Amar Drawid to discuss the potential of real-world data to accelerate drug development and improve regulatory strategies. He discusses why real-world data can provide insights may miss, shed light on treatment effects once approved, and how it may one day reshape the drug approval process.
2025-10-091h 00The Real World Perspective with Manfred Stapff, MD, PHDVaccines and Society: Balancing Science, Ethics, and PoliticsVaccines have saved millions of lives. Yet they remain one of society's fiercest dividing lines. In this episode, Dr. Manfred Stapff confronts why vaccines spark both trust and resistance, examining the science, ethics, and politics that fuel the debate. He explains why the evidence is clear: vaccines prevent severe illness and save lives. Mild side effects signal an active immune system, while serious reactions are extremely rare compared to the dangers of the diseases themselves. Still, misinformation, poor communication, and political agendas distort the conversation and erode public trust. Vaccination is more than personal protection...
2025-10-0715 minThe Real World Perspective with Manfred Stapff, MD, PHDNutrition Lies and the Obesity CrisisObesity affects nearly 40% of Americans, making it one of today's most urgent health crises. In this episode, Dr. Manfred Stapff cuts through confusion and misinformation to show what the data truly reveal about nutrition and obesity. Dr. Manfred explains why excess calories not burned through daily activity drive weight gain, and how obesity fuels risks for diabetes, cancer, and premature death. Drawing on major studies, he exposes the flaws in self-reported nutrition research while offering simple, evidence-based rules: keep calories around 2,000, eat more protein, cut back on carbs and sugar, and skip late-night snacks. The me...
2025-09-3017 minThe Real World Perspective with Manfred Stapff, MD, PHDData, Decisions, and Danger: What Evidence Reveals About Tattoos and CannabisMarijuana smoking and tattoos are personal choices. What does the evidence really say about their health risks? In this episode, Dr. Manfred Stapff cuts through the myths, and delivers the science-backed truth about weed, ink, and your well-being. Using a major California study, he explains why cannabis users face a threefold higher risk of oral cancer and why the real story lies in understanding absolute risk and the "number needed to harm." Dr. Manfred then turns to tattoos, uncovering a Swedish study that hints at a troubling link to lymphoma, and revealing how hidden metals a...
2025-09-2315 minThe Real World Perspective with Manfred Stapff, MD, PHDBeyond the 18% Hike: What's Broken in the Health Care System of UnitedHealthcareHealthcare costs are rising, but are the reasons valid? In this episode, Dr. Manfred Stapff examines UnitedHealthcare's proposed 18% rate hike and asks: where's the evidence? Using authoritative data from CMS and PricewaterhouseCoopers, Dr. Manfred reveals how this price increase sharply diverges from national healthcare cost trends. He confronts the growing tension between record-breaking profits and patient affordability, and challenges the flawed logic of treating healthcare as a free-market commodity. With clarity and depth, this episode equips listeners to question inflated costs, analyze systemic inefficiencies, and rethink the incentives behind our healthcare decisions. Gain...
2025-09-2310 minThe Real World Perspective with Manfred Stapff, MD, PHDUncovering the Correlation Between Measles, Vaccines, and AutismVaccines and autism spark fierce debate, where science meets emotion. This episode offers sharp, confident clarity. Dr. Manfred Stapff cuts through decades of controversy on breaking down the supposed link between the measles vaccine and autism. With firm, science-backed insights, he shows how rigorous research, not headlines, has shaped what we know today. He highlights the measles vaccine's stunning success, the science behind immunity, and why fears sparked by the flawed Wakefield paper still linger. You'll learn how real evidence is built and why emotions, though natural, can cloud judgment when weighed against overwhelming data.
2025-09-2314 minThe Real World Perspective with Manfred Stapff, MD, PHDFacts, Fear, and Future: Exposing Misinformation with Real-World EvidenceIn a world overwhelmed by conflicting headlines, viral rumors, and half-baked statistics, how can one tell what's real? In this episode, Dr. Manfred Stapff breaks down the science behind real-world evidence (RWE) and reveals how it can be used to separate fact from fiction in public health, media, and policy conversations. He carefully guides audiences through real examples, like the GLP-1 drug studies and COVID mask debates, to show how well-intended data can become misleading when stripped of scientific rigor or proper communication. Whether you're a policymaker, academic, healthcare provider, or simply a c...
2025-09-2230 min
Transformation in TrialsDecoding Real-World Evidence: Beyond Clinical Trials with Manfred StapffSend us a textWhat if millions of electronic health records could transform how we understand medicine? In this thought-provoking conversation with Dr. Manfred Stapff, physician and real-world evidence pioneer, we uncover how anonymized patient data is revolutionizing healthcare research.Dr. Stapff reveals how the 21st Century Cures Act dramatically accelerated electronic medical record adoption in the US, creating unprecedented opportunities for researchers. Today, with 90-95% of American hospitals digitized and similar progress across parts of Europe, we're witnessing a fundamental shift in how medical knowledge is generated. But this transformation comes with crucial questions...
2025-09-1031 min
Broadcast Your AuthorityReal-World Evidence: Why Most Clinical Trials Fail in Real Life TreatmentIn this episode of Broadcast Your Authority, Dr. Manfred Stapff, physician, global researcher, and author of Real-World Evidence Unveiled, pulls back the curtain on what really happens when controlled clinical trials meet real-world treatment. Dr. Manfred shares why a patient's behavior can shift the moment they enter a trial, how statistics can be bent to tell a misleading story, and why AI is both a game-changing ally and a dangerous manipulator in modern medicine. He also shares his "Red Face Test" for catching questionable health claims and discusses how freedom of speech comes with the...
2025-08-2229 min
Note to File: A Clinical Research PodcastHow Real World Evidence is Changing Medicine - Dr. Manfred Stapff on Data, AI & TrustJoin us for an insightful conversation with Dr. Manfred Stapff, author of "Real World Evidence Unveiled: Navigating the Maze of Modern Misinformation." In this episode, we explore the differences between clinical trials and real-world evidence, the challenges of translating research into everyday medical practice, and the importance of diversity in clinical studies. Dr. Stapff discusses the growing problem of misinformation in medicine and media, the role of AI in both spreading and combating false information, and the ethical questions surrounding data privacy and ownership. Check his book here:https://a.co/d/ishaCNI
2025-08-1459 min
Progress, Potential, and Possibilities Podcast / ShowDr. Manfred Stapff, MD, PhD - Founder, Candid Advisory - Real-World Evidence UnveiledSend us a textDr. Manfred Stapff, MD, PhD is a physician and pharmaceutical industry leader with over 30 years of experience in internal medicine, clinical research, and drug development, who has worked across a range of therapeutic areas including NASH, CV, CNS, respiratory, oncology, GI, anti-infective, and orphan diseases.Dr. Stapff has held senior roles at Merck & Co., Forest Laboratories (now Allergan), and LG Chem (CMO / COO), specializing in clinical development, regulatory affairs, and global medical operations. As Chief Medical Officer at TriNetX, he helped build the worldʼs largest real-world data (RWD) re...
2025-05-061h 01
Clinical Trial Podcast | Conversations with Clinical Research ExpertsThe Future with EMR with Dr. Manfred Stapff"It is important that you start with the big picture" - Dr. Manfred Stapff This is episode Dr. Manfred Stapff, Chief Medical Officer at TriNetX shares with us the use and application of real-world data in clinical trial. Manfred Stapff is a physician and board-certified clinical pharmacologist with an extensive career in clinical and pharmaceutical medicine. He was formerly an Executive Director at Actavis, Forest Laboratories, and Merck and also served as a Medical Officer in the German Air Force. Manfred earned his MD and Ph.D. from the Ludwig Maximilian University of Munich. In this interview, Manfred...
2018-01-0549 min