Shows
MedEvidence ArticlesCan Amylin Help Us Navigate Our Way to a Healthy Weight?On this week's episode we investigate the molecule amylin, a hormone that also affects the body and brain. Amylin is released in response to eating, and helps us know when we're full. We look at what amylin is, how it works, and how investigational versions of the hormone may help with obesity and weight loss.References:Lange O, Perez L. Traffic prediction with advanced graph neural networks. Google Deepmind Blog. Published September 3, 2020. Accessed February 11, 2026. https://deepmind.google/blog/traffic-prediction-with-advanced-graph-neural-networks/Billings LK, Hsia S, Bays H, Tidemann-Miller B, O’Hagan J, San Th...
2026-03-0204 minMedEvidence ArticlesClearing the Traffic for Treating Major DepressionOn this week's episode, we show an increased drive into vagus nerve stimulation clinical research. This FDA-approved therapy for major depressive disorder (MDD) is undergoing further trials in an effort to get it approved by big insurance carriers like Medicaid.Hasin DS, Sarvet AL, Meyers JL, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry. 2018;75(4):336–346. doi:10.1001/jamapsychiatry.2017.4602Substance Abuse and Mental Health Services Administration. DSM-5 Changes: Implications for child serious emotional disturbance [Internet]. Substance Abuse and Mental Health Services Administration. 2016. Accessed December 22, 2025. https://www.ncbi.nlm.ni...
2026-01-1905 minMedEvidence ArticlesBig Clinical Trials on the Horizon for ObesityOn this week's episode, we look into the calculations being made to develop new obesity treatments. We go into the history, current best practices, body changes, and some possible new solutions in the weight loss field.References:NIDDK. Overweight & Obesity Statistics. U.S. Department of Health and Human Services. https://www.niddk.nih.gov/health-information/health-statistics/overweight-obesity Accessed December 22, 2025.Kuk JL, Rotondi M, Sui X, Blair SN, Ardern CI. Individuals with obesity but no other metabolic risk factors are not at significantly elevated all‐cause mortality risk in men and women. Clinical obesity. 2018 Oct...
2026-01-1205 minMedEvidence ArticlesDon’t drop the ball on your New Year’s ResolutionIn this week's episode, originally written in 2022, we look at some of the science behind creating and maintaining a successful New Year's resolition. We explore how language, habit, and brain science can all make a difference in makign a better you.References:Larimer ME, Palmer RS, Marlatt GA. Relapse prevention: An overview of Marlatt's cognitive-behavioral model. Psychosocial treatments. 2004 Jun 1:1-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760427/Oscarsson M, Carlbring P, Andersson G, Rozental A. A large-scale experiment on New Year’s resolutions: Approach-oriented goals are more successful than avoidance-oriented goals. PLoS One. 2020 Dec 9;15(12):e0...
2026-01-0506 minMedEvidence ArticlesClinical Research Is a Care OptionIn this week's episode, written by guest author Chase Berger, we explore the positive health benefits of clinical research beyond the obvious. We look at how those who can particiapte in clinical research have an alternative method of interacting with healthcare professionals that is quick, consistent, and pateint-oriented.References:Koren, M.J., Geddings, K., (17 November, 2025). Coordinated care through clinical research. On MedEvidence! Truth Behind the Data. [Podcast]. https://www.medevidence.com/coordinated-care-through-clinical-researchKoren, M.J., Collins, S., (3 December, 2025). Equity through clinical research. On MedEvidence! Truth Behind the Data. [Podcast]. https...
2025-12-2903 minMedEvidence ArticlesThe Science of Gift GivingIn this week's episode, which revisits a topic from several years ago, we go deep into the brain to explore what happens inside whe nwe give gifts. We explore a few studies which have looked at brain activity during gifting - including during diffrent types of gifting - and explore why giving gifts makes you feel good, connects you with friends, and acts as a prosocial activity.References:Aknin, L. B., Barrington-Leigh, C. P., Dunn, E. W., Helliwell, J. F., Burns, J., Biswas-Diener, R., ... & Norton, M. I. Prosocial Spending and Well-Being: Cross-Cultural...
2025-12-2204 minMedEvidence ArticlesHow to Avoid Holiday Heart SyndromeIn this episode we explore the less cheery side of the holidays: holiday heart syndrome. This syndrome is defined as irregular heartbeats that occur as a result of binge drinking, the type of which is frequently seen around the holidays. We explore the risks, outcomes, mechanics, and treatments of this not-so-happy heart syndrome.References:Jain, A., Yelamanchili, V. S., Brown, K. N., & Goel, A. (2024). Holiday heart syndrome. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK537185/World Health Organization. (January 4, 2023). No level of alcohol consumption is...
2025-12-1504 minMedEvidence ArticlesGout Isn’t Purely a Problem Of Passing PurineIn this week's episode, we explore the stream of causes that can lead to the painful inflammatory condition gout. We look at the risks, progression, mechanics, and solutions available for this most common inflammatory arthritis. The primary cause of gout is excessive urate in the the blood depositing itself, especially toes. We then look ahead to clinical trials that recently wrapped up or are currently underway and which target the underlying urate in the blood or the immune response to urate crystals in joints.ReferencesDalbeth, N., Choi, H. K...
2025-12-0807 minMedEvidence ArticlesThe Placebo Effect Uses Fake Medicine to Get Real ResultsIn this week's episode, we talk about placebos, which are inert "medications" used to compare with active drugs. We talk about how the use of medications that "do nothing" can provide pain relief, change hormone balance int he body, and lower symptoms across a broad variety of diseases.References:Beecher, H. K. (1955). The powerful placebo. Journal of the American Medical Association, 159(17), 1602-1606. https://jamanetwork.com/journals/jama/article-abstract/303530Wager, T. D., & Atlas, L. Y. (2015). The neuroscience of placebo effects: connecting context, learning and health. Nature Reviews Neuroscience, 16(7), 403-418. https://www...
2025-12-0104 minMedEvidence ArticlesThinking Our Way to Better HealthIn this week's episode, we explore some specific, actionable methods for increasing gratitude. These include gratitude journaling, gratitude letters, mental subtraction, and experiantial consumption. We go over what the methods are, how they work, and how expressing gratitude may help mental health.References:Allen, S. (2018). The science of gratitude (pp. 1217948920-1544632649). Conshohocken, PA: John Templeton Foundation. https://ggsc.berkeley.edu/images/uploads/GGSC-JTF_White_Paper-Gratitude-FINAL.pdfDickens, L. R. (2017). Using gratitude to promote positive change: A series of meta-analyses investigating the effectiveness of gratitude interventions. Basic and Applied Social Psychology, 39(4), 193...
2025-11-2405 minMedEvidence ArticlesThe Goodness of GratitudeOn this week's episode, we talk about gratitude, and how it can affect mood, positive emotions, and even biological markers of health.References:Allen, S. (2018). The science of gratitude (pp. 1217948920-1544632649). Conshohocken, PA: John Templeton Foundation. Boggiss, A. L., Consedine, N. S., Brenton-Peters, J. M., Hofman, P. L., & Serlachius, A. S. (2020). A systematic review of gratitude interventions: Effects on physical health and health behaviors. Journal of Psychosomatic Research, 135, 110165. https://doi.org/10.1016/j.jpsychores.2020.110165McCullough, M. E., Emmons, R. A., & Tsang, J. A. (2002). The grateful disposition: a conceptual and e...
2025-11-1704 minMedEvidence ArticlesCool Developments in COPD MedicineIn this week's episode, we talk about how targeting a specific immune cell called an eosinophil may help lower the burden of COPD (chronic obstructive pilmonary disease). We explore the epidemiology, pathophysiology, and treatment options for COPD, including targeting the eosinophil pathway.References:Bhatti, M. S. (1999). A historical look at chlorofluorocarbon refrigerants. ASHRAE Transactions, 105, 1186. https://www.osti.gov/biblio/20002388Narendra, D. K., & Hanania, N. A. (2019). Targeting IL-5 in COPD. International journal of chronic obstructive pulmonary disease, 1045-1051. https://www.tandfonline.com/doi/full/10.2147/COPD.S155306World Health Organization. (6...
2025-11-1004 minMedEvidence ArticlesImproving Flu Vaccine Effectiveness Through Clinical Research and AdjuvantsIn this episode, we explore the role of adjuvants in vaccines. These addatives help the immune response to a vaccine, making it more effective at stoping infection, complication, hospitalization, and or death. We discuss the need for better vaccines and how adjuvants may be able to help.References:Grohskopf, L. A. (2019). Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season. MMWR. Recommendations and Reports, 68. https://www.cdc.gov/mmwr/volumes/73/rr/rr7305a1.htmGross, P. A., Hermogenes, A. W...
2025-11-0404 minMedEvidence ArticlesThe Scariest Skeleton Is the One with OsteoporosisIn this week's episode we explore osteoporosis, a condition where there's "too little bone in the bone." We look at how bones work normally ,adn compare that to the risks, pathophysiology, and treatments available to those with osteoporosis.References:Marcus, R., Dempster, D. W., Cauley, J. A., & Feldman, D. (Eds.). (2013). Osteoporosis. Academic Press. Reginster, J. Y., & Burlet, N. (2006). Osteoporosis: a still increasing prevalence. Bone, 38(2), 4-9. https://www.sciencedirect.com/science/article/pii/S8756328205005272Sarafrazi, N., Wambogo, E. A., & Shepherd, J. A. (2021). Osteoporosis or low bone mass in older a...
2025-10-2806 minMedEvidence ArticlesWhat My Cat Taught Me About Monoclonal AntibodiesIn this week's episode, we explore what monoclonal antibodies are, how they make things happen in the body, and how they can be used in medicine. We discuss how they can be used for identifying cells, delivering drugs to specific cells, or anything in between. Tune in to learn about monoclonal antibodies and hwo they relate to a cat who's a picky eater.References:Nelson, P. N., Reynolds, G. M., Waldron, E. E., Ward, E., Giannopoulos, K., & Murray, P. G. (2000). Demystified…: monoclonal antibodies. Molecular pathology, 53(3), 111. https://pmc.ncbi.nlm.nih.gov/articles/PM...
2025-10-2005 minMedEvidence ArticlesWhat a Cold War Hero Can Teach Us About Chronic HivesOn this week's episode, we explore the ins and outs of chronic spontaneous urticaria. We discuss the signs, symptoms, complications, and how-it-works of the disease, including how linchpin molecules in the cell like Bruton's tyrosine kinase may be the key to tempering extreme reposnses from a hair-trigger immune system.References:Isachenkov, V. (2017, September 19). Stanislav Petrov, who averted nuclear war, dies at 77. The Associated Press. https://apnews.com/general-news-b9de4e3c9a5949e4a27e8ea601059f25Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al (2022) The international EAACI/GA²L...
2025-10-1306 minMedEvidence ArticlesUntreated MASH Can Be a Driver of Liver DiseaseIn this week's episode we review fatty liver disease, called metabolic dysfunction–associated steatotic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis, or MASH. We look at the prevalence, risks, and complications of this dangerous disease. Then we get into the nuts and bolts of how MASLD and MASH work and some of the treatment options available.References:Allen, A. M., Younossi, Z. M., Diehl, A. M., Charlton, M. R., & Lazarus, J. V. (2024). Envisioning how to advance the MASH field. Nature Reviews Gastroenterology & Hepatology, 21(10), 726-738. https://www.nature.com/articles/s41575-024-00938-9...
2025-10-0207 minMedEvidence ArticlesBanking on New Eosinophilic Esophagitis (EoE) TreatmentsIn today's episode we discuss an immune-mediated disease, eosinophilic esophagitis, or EoE. We review the symptoms, risks, and damage this disease can cause. We also get into what happens inside the body during and what's being done in both standard medicine and clinical research to try to end EoE.References:[1] Muir, A., & Falk, G. W. (2021). Eosinophilic esophagitis: a review. Jama, 326(13), 1310-1318. https://pmc.ncbi.nlm.nih.gov/articles/PMC9045493/[2] Nurko, S., & Furuta, G. T. (2006). Eosinophilic esophagitis. GI Motility online. https://www.nature.com/gimo/contents/pt1/full/gimo49.html[3...
2025-09-2906 minMedEvidence ArticlesLiving With Crohn’s DiseaseIn this podcast, we explore Crohn's disease: who it affects, what it is, how it works in the body, and what you can do about it. We relate the disease to screens on windows, which can degrade over time, letting unwanted bugs in the house. Tune in for the who, how, and what can be done about Crohn's!References:Roda, G., Chien Ng, S., Kotze, P. G., Argollo, M., Panaccione, R., Spinelli, A., ... & Danese, S. (2020). Crohn’s disease. Nature reviews Disease primers, 6(1), 22. https://doi.org/10.1038/s41572-020-0156-2Peyrin-Biroulet, L...
2025-09-2607 minMedEvidence ArticlesNavigating ADHDIn this week's episode, we set sail to explore Attention-Deficit Hyperactivity Disorder, or ADHD. We cruise past the risks, symptoms, and what actually happens inside the brain to make increase impulsivity, inattentiveness, and hyperactivity. Finally, we shoot the breeze with various treatment options, including medical, therapy-based, and alternative.References:Norman, L. J., Sudre, G., Price, J., Shastri, G. G., & Shaw, P. (2023). Evidence from “big data” for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples. Neuropsychopharmacology, 48(2), 281-289. https://www.nature.com/articles/s41386-022-01408-zAyano, G., Deme...
2025-09-2207 minMedEvidence ArticlesAre Robots More Dangerous Than Cholesterol? No.In this episode we dive deep into new technologies in the ongoing attempt to get cholesterol levels under control worldwide. Heart disease remains the #1 killer in America, and much of the blame falls on high cholesterol. We go into what cholesterol is and some of the new targets and technologies being developed now to help keep the body in line producing the right amount of the right proteins for good cholesterol control.References:Occupational Safety and Health Administration. (2025). Accident search results: Keyword “Robot”. U.S. Department of Labor. Accessed 3 September, 2025. https://www.osha...
2025-09-1908 minMedEvidence ArticlesMarijuana, THC, and the Science of Pain ReliefIn this week's episode, we explore the use of marijuana (cannabis) as a pain relief medication. We go over the main psychoactive component of marijuana, THC, how it works, and how it interacts with neurons in the brain and body to lower our perception of pain.References:Rikard, S. M. (2023). Chronic pain among adults—United States, 2019–2021. MMWR. Morbidity and Mortality Weekly Report, 72. https://pmc.ncbi.nlm.nih.gov/articles/PMC10121254/Knopp, K. L., Downing, A. M., Anthony, L., Chaterjee, S., Price, K., & Sparks, J. (2024). An innovative phase 2 chronic pain master prot...
2025-09-0205 minMedEvidence ArticlesUnderstanding Celiac Disease and the Latest ResearchOn this week's episode, we review celiac disease. We talk about what it is, and what goes wrong inside the body. We discuss the underlying genetic factors and why genetics alone aren't enough to guarantee celiac disease. We wrap up on a hopeful note, exploring new avenues to be explored in clinical research trials.References:Lebwohl, B., & Rubio-Tapia, A. (2021). Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), 63-75. https://www.gastrojournal.org/article/S0016-5085%2820%2935165-9/fulltextLindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E., Makharia, G. K., Mearin...
2025-08-2505 minMedEvidence ArticlesBuilding Solutions to Chronic Pain Through Clinical ResearchIn this week's episode, we explore how pain works, some of the causes of pain, and some of the possible solutions to chronic pain. We look at the who, what, and the how of pain in the body - and how its a brain process as much has in the body process.References:Kuner, R., & Flor, H. (2017). Structural plasticity and reorganisation in chronic pain. Nature Reviews Neuroscience, 18(1), 20-30. https://www.nature.com/articles/nrn.2016.162Borges, J. P., Mekhail, K., Fairn, G. D., Antonescu, C. N., & Steinberg, B. E. (2021). Modulation of...
2025-08-1406 minMedEvidence ArticlesWhat Happened After World War One? World War FluOn this week's episode, we review the history of the flu. We explore ancient flu pandemics, the "Spanish flu" of 1918, and the state of the flu today. In addition, we explore why the flu is so hard to achieve lasting immunity from infection or vaccination. We also get into the nitty-gritty of what the flu is, how it works, and what's being done in the world of science and clinical research to help protect us better.References:Trilla, A., Trilla, G., & Daer, C. (2008). The 1918 “spanish flu” in spain. Clinical infectious diseases, 47(5), 668-673. http...
2025-08-1106 minMedEvidence ArticlesDealing with Autosomal Dominant Polycystic Kidney Disease (ADPKD)On this week's episode, we look at an increasingly full house of treatments which are being developed to join the club of autosomal dominant polycystic kidney disease medications. We look at what ADPKD is, who it affects, and what kinds of treatments on the horizon may be a diamond in the rough. Find out all about ADPKD in this fun podcast that raises spirits, suits a quest for knowledge, and doesn't bluff about this condition!References:Cornec-Le Gall, E., Alam, A., & Perrone, R. D. (2019). Autosomal dominant polycystic kidney disease. The Lancet, 393(10174), 919-935...
2025-08-0405 minMedEvidence ArticlesThe Brain's Worst Hit: Understanding Traumatic Brain InjuryOn this week's episode, written by guest author Christy Kestner, PhD, we discuss traumatic brain injury; when the brain gets banged around enough to cause damage. We explore the causes, problems, some ways to protect yourself, and what to do if you or someone you know experiences a traumatic brain injury; along with signs and symptoms to help identify one.References: Taylor, C. A., Bell, J. M., Breiding, M. J., & Xu, L. (2017). Traumatic Brain Injury-Related Emergency Department Visits, Hospitalizations, and Deaths - United States, 2007 and 2013. Morbidity and mortality weekly report. Surveillance summaries (Was...
2025-07-2806 minMedEvidence ArticlesHow Inflammation Threatens Your Kidneys and HeartChronic kidney disease (CKD) is incredibly common, affecting 1 in 7 Americans, and heart disease is a common cause of death for those with CKD. In this week's article we explore the role inflammation plays in chronic kidney disease and how the same inflammation that damages the kidneys may also lead to damage in other parts of the body, including the heart. We also review why inflammation is beneficial in low amounts and what's being done to help lower chronic inflammation without compromising this vital immune response.References:Kadatane, S. P., Satariano, M., Massey...
2025-07-2107 minMedEvidence ArticlesSteering Treatments for Major Depressive DisorderIn this week's episode we review Major Depressive Disorder, a common mental disorder affecting millions of Americans. We explore who this disorder affects, what happens in the brain and body, and what treatments are available. We also get into the psychadellic substance psilocybin (psylocin) and how this breakthrough therapy may help those with Major Depressive Disorder.References:Substance Abuse and Mental Health Services Administration. (2019). Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. HHS Publication No. PEP19-5068, NSDUH Series...
2025-07-1406 minMedEvidence ArticlesBeneath the Surface of Hidradenitis SuppurativaIn this week's episode, we explore the chronic inflammatory skin condition Hidradenitis Suppurativa (HS). With HS, hair follicles located in large skin creases like the armpits become inflamed and clogged. The units, called the pilosebaceous unit, fill with puss, rupture, and cause a host of problems for sufferers. We investigate what hidradenitis suppurativa is, who it affects, what goes wrong in the body, and what's being done about it.References:Schramm, E. & Bernhardt, M. (11 June, 2025). Modern Medicine is Transforming Hidradenitis Suppurativa Treatment. On MedEvidence! Truth Behind the Data. [Podcast]. https://medevidence.com/modern-medicine-is-transforming-hidradenitis-suppurativa-treatment
2025-07-0705 minMedEvidence ArticlesDehydration Isn't a Day at the BeachIn this episode we review what happens in dehydrtion, who may be at increased risk, and what happens to the body when it doesn't get enoug hwater. We also distinguish between two major types of dehydration; intracellular (without salt loss) and extracellular (with salt loss). Learn all about how this summer condition can lead to problems that feel as dangerous as being marooned on a desert isle!References:Cheuvront, S. N., & Kenefick, R. W. (2014). Dehydration: physiology, assessment, and performance effects. Comprehensive physiology, 4(1), 257-285. https://onlinelibrary.wiley.com/doi/full/10.1002/j.2040-4603.2014.tb00543...
2025-06-3006 minMedEvidence ArticlesThe Cost of Extra Weight on Heart Failure RiskThis week, we investigate the links between heart failure and obesity. We explore what heart failure is, the risks, and how it can have long-term impacts on health. We also look into obesity, some of it's causes, and how it can contribute to heart failure risks. We also look at he two-way street between heart failure and obesty and how each can contribute to the other in a feedback loop, and what may be done to break it.References:Upadhyay, J., Farr, O., Perakakis, N., Ghaly, W., & Mantzoros, C. (2018). Obesity as a...
2025-06-2305 minMedEvidence Articles85–90% of Primary Liver Cancers Are Hepatocellular Carcinoma, Why Aren’t We Catching It Sooner?Hepatocellular Carcinoma (HCC) is the most common cause of primary liver cancer. Curative treatments include surgery and transplant, but many patients don't know they have the disease until it's too late. In this week's article, we explore what HCC is, risks and complications of the disease, and what people can do to find out if they have signs of the HCC before it spreads too far.References:Koren, M.J. & Kapila, N. (Hosts). (2025). The liver: Common causes of complications, cirrhosis, and cancer. [Podcast Episode]. In MedEvidence! Truth Behind the Data. MedEvidence. https...
2025-06-1606 minMedEvidence ArticlesFrom Cross-Contamination to Cure: Hepatitis CIn this week's episode, we look into the history of Hepatitis C. The hepatitis C virus spread far and wide during the era before modern sterilization and screening, infecting millions. We look into the history, risks, symptoms (many have none!), and complications of hepatitis C. Finally, we look at how far treatment has progressed and what's coming up on the horizon.References:Khalili, M., & Burman, B. (2014). Liver disease. In Hammer, G. D., & McPhee, S. J. (Eds.). Pathophysiology Of Disease An Introduction To Clinical Medicine (7th ed., pp. 385-425). McGraw-Hill Education.https://archive...
2025-06-1205 minMedEvidence ArticlesSpeaking About Social Anxiety DisorderIn this episode, we delve into the science and struggle behind social anxiety disorder. This condition affects millions of people and often begins in childhood. We explore how the brain’s fear circuitry becomes overactive, and common treatments like SSRIs. We also highlight an intriguing new treatment being tested: a nasal spray of pheromone-like compounds aimed at calming fear responses.References:Leichsenring, F., & Leweke, F. (2017). Social anxiety disorder. New England Journal of Medicine, 376(23), 2255-2264. https://www.nejm.org/doi/abs/10.1056/NEJMcp1614701American Psychiatric Association. (2013). Social anxiety disorder. In Diagnostic and st...
2025-05-2705 minMedEvidence ArticlesGastroparesis Turns Meals into MiseryIn this episode, we explore the complex world of gastroparesis. Gastroparesis is a condition that slows the stomach’s ability to empty food and turns mealtime into a daily challenge. From the science behind digestion to the symptoms, causes, and evolving treatments for idiopathic gastroparesis, we break down what happens when the stomach stops cooperating. Learn how this disorder affects quality of life and what new therapies would look like to help people enjoy food again without the side effects.References:Parkman, H. P., Jacobs, M. R., Mishra, A., Hurdle, J. A., Sa...
2025-05-2103 minMedEvidence ArticlesWhen Life Gives You Limes, Solve ScurvyScurvy, a disease caused by vitamin C deficiency, once killed thousands of sailors during long sea voyages. The breakthrough came in 1747 when Dr. James Lind conducted the first recorded clinical trial, proving citrus fruits could prevent the illness. British sailors were later issued lime juice, earning them the nickname “limeys.” Though now considered offensive by some, the term reflects an important medical milestone and the early use of evidence-based treatment. References:Oxford University Press. (n.d.). Limey. In Oxford English dictionary. Retrieved April 14, 2025, from https://www.oed.com/dictionary/limey_nCha...
2025-05-1605 minMedEvidence ArticlesTinnitus Treatments Result From Clinical TrialsThis week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and there are some symptomatic treatments. Listen in to find out what tinnitus is, risks and complications, and some ways you may be able to find relief.References:Bhatt, J. M., Lin, H. W., & Bhattacharyya, N. (2016). Prevalence, severity, exposures, and treatment patterns of tinnitus...
2025-05-1204 minMedEvidence ArticlesCan We Train the Immune System to Kill Cancer?In this week's episode, we jump into the emerging field of personalized cancer vaccines. Cancer remains the second leading cause of death worldwide due to its complex nature. "Cancer" actually encompasses over 275 diseases, each driven by genetic mutations that make cancer cells act independently and harmfully within the body. Find out how scientists are using genetics to identify unique targets for individual people's cancers and using these targets to train our own immune system using cancer vacines.References:Hassanpour, S. H., & Dehghani, M. (2017). Review of cancer from perspective of molecular. Journal of...
2025-05-0504 minMedEvidence ArticlesVascular Dementia: Causes, Symptoms, Risk Factors, and Treatment OptionsIn this week's episode, we talk about vascular dementia, a significant yet often overlooked brain disorder caused by reduced blood flow, usually due to stroke and/or vascular disease. It accounts for 15-20% of dementia cases and leads to cognitive decline, memory loss, and motor impairments. While no cure exists, prevention is key—controlling risk factors like high blood pressure, diabetes, and smoking can significantly reduce the likelihood of developing the disease. Research suggests that physical fitness offers strong protective benefits, and some Alzheimer’s medications may provide limited relief. Continued clinical trials are essential in the search for effe...
2025-04-2803 minMedEvidence ArticlesWhy Measles Has Gone From Eradicated To OutbreakMeasles a highly contagious virus that can cause serious complications, including pneumonia, brain swelling, and death. It was declared eradicated in the U.S. in the year 2000 but has resurfaced, with over 700 cases reported so far this year. What are the causes of this latest outbreak? Despite a long history of vaccine success, recent declines in MMR vaccination rates have made populations vulnerable again. Historically, vaccination efforts drastically reduced measles cases, but global travel and misinformation now threaten that progress. Listen now to find out the facts, history, and factors contributing to the currentmeasles outbreak in the U.S.
2025-04-2106 minMedEvidence ArticlesPsoriasis and the Immune System: More Confusing Than Teenage SlangOn this week, we discuss psoriasis, a chronic autoimmune disease affecting 2-3% of Americans. It's characterized by red, flaky skin and linked to serious health conditions like arthritis and cardiovascular disease. It results from an overactive immune response which may be initiated or worsened by environmental factors such as stress, obesity, and smoking. Inside the body, immune molecules -including T helper cells, interleukins, and TYK2 - are overactive and lead to excessive skin cell production. Medications for moderate to severe psoriasis target these immune molecules, though more clinical trials are needed to balance with effectiveness with side effects.
2025-04-1405 minMedEvidence ArticlesClinical Trials Have Opened Doors to COPD MedicationsIn this week we talk about chronic obstructive pulmonary disease (COPD), a progressive lung condition that restricts airflow due to chronic bronchitis and emphysema, which damages the alveoli. COPD affects around 11% of adults over 30 and is linked to smoking, pollution, and genetic factors. This episode relates COPD to a house with big rooms and narrow doors, making furnishing a challenge, and fives into the mechanisms, symptoms, and treatments for the disease.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released....
2025-04-0706 minMedEvidence ArticlesA New Type of Memory Loss in Older AdultsThis podcast explores Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), a newly identified condition that primarily affects episodic memory while leaving other cognitive functions relatively intact. LANS is associated with the misfolding of TDP-43, a protein that can accumulate and damage limbic structures. Unlike Alzheimer’s, LANS has a slower onset and lacks definitive diagnostic tests, making research critical for future treatments. With the aging population, understanding and addressing LANS could become as significant as Alzheimer’s research. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are relea...
2025-03-3105 minMedEvidence ArticlesAlzheimer’s at the Genetic LevelMedical treatments are shifting from broad approaches to precise genetic targeting, especially for finicky diseases like Alzheimer's dementia. While many past efforts focused on amyloid β plaques, new research is exploring genetic regulators like APP, which influences amyloid levels, and KDM5, an enzyme linked to memory and cognition. Clinical trials are testing drugs that could balance these proteins and potentially slow cognitive decline at its root. Tune in this week for a deep look into the genetics of Alzheimer'sShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are r...
2025-03-2405 minMedEvidence ArticlesDigging Up the Truth About PotatoesThis St. Patrick's Day we explore the history, nutritional profile, and potential health benefits of potatoes. Potatoes are a major global food staple, providing significant calories worldwide. Though often criticized for their high glycemic index (GI), different cooking methods, particularly chilling after cooking, can increase resistant starches, which improve gut health and reduce blood sugar impact. Potatoes also have a high satiety index, making them more filling than many other foods. While long-term clinical studies are needed, current epidemiological data suggest that potatoes are not linked to negative health outcomes—unless consumed as french fries.
2025-03-1705 minMedEvidence ArticlesWhat are Cluster Headaches?In this week's episode, we discuss cluster headaches, one of the most severe pain conditions known. This rare condition affects about one in a thousand people with excruciating, clockwork-like attacks can last for weeks or months, with few effective treatment options. In this episode, we break down the causes, triggers, and latest research on cluster headaches, from abortive therapies like oxygen and triptans to emerging neuromodulation treatments.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:Facebook
2025-03-1006 minMedEvidence ArticlesAlzheimer’s Anxiety: What’s Normal, What’s Not, and When to ActForgetting a name or misplacing your keys can be frustrating, but when does memory loss signal something more serious? In this episode, we explain the key differences between normal aging and Alzheimer’s disease. We break down how doctors diagnose Alzheimer’s, the role of biomarkers, and why early detection is crucial for those considering clinical trials.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTikt...
2025-03-0303 minMedEvidence ArticlesNew Research on Heart Failure: Understanding IL-6 and InflammationThis week, we talk about one of the big contributors to heart failure: inflammation. Heart failure affects millions and comes in two main types: HFrEF (weakened pumping) and HFpEF (thickened, stiff walls). While conditions like high blood pressure and diabetes contribute, chronic inflammation—driven in part by Interleukin 6 (IL-6)—plays a major role. IL-6 causes muscle damage, fibrosis, and worsens other diseases. Researchers are developing monoclonal antibodies to regulate IL-6, offering a potential breakthrough technology in reducing inflammation and improving heart health. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when...
2025-02-2104 minMedEvidence ArticlesShort Circuits in the Heart: A Look at Atrial FibrillationWhen the hot water went out, you might call a plumber, but if the water heater is out it might instead be an electrical problem - just like how heart problems can stem from faulty electrical signals rather than the heart muscle itself. Atrial fibrillation (AFib), the most common arrhythmia affecting six million Americans, disrupts the heart’s electrical system, causing rapid, chaotic beating that increases stroke risk fivefold. In this week's episode, we review AFib, the risk factors to develop it, symptoms , how it happens, and treatments. Water you waiting for, listen today!Share with a...
2025-02-1005 minMedEvidence ArticlesThe Heart is the Beat of LifeThis week's podcast is a crash course on what the heart is, why we need it, how it works, and what can go wrong.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.comThank you for listening!
2025-02-0304 minMedEvidence ArticlesAlzheimer’s and ADHD, the Missing Link?This week we talk about two recent studies which suggest a potential link between adult ADHD and an increased risk of developing dementia; though causation remains unproven. These studies, one in Israel and another in Sweden, found that adults with ADHD were significantly more likely to develop dementia or mild cognitive impairment. These findings were consistent across most demographics, though ADHD medication appeared to reduce the risk. The research highlights the need for further exploration into shared mechanisms between these conditions and raises questions about whether ADHD may predispose the brain to dementia or if certain factors, such as...
2025-01-2706 minMedEvidence ArticlesShiny Legs, Hidden DangerThis week we discuss peripheral artery disease (PAD), a condition affecting blood flow in the peripheral arteries, most commonly in the legs. We cover its symptoms, such as leg pain, skin changes, and slow-healing wounds, as well as the potential risks of untreated PAD, including amputation and cardiovascular complications. We then talk about treatment options, including medications, lifestyle changes, structured exercise programs, and advanced interventions like revascularization.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:Facebook
2025-01-2706 minMedEvidence ArticlesIs the Deadliest Condition Preventable? Understanding ASCVD and LDL-CThis episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episode highlights preventive strategies such as healthy lifestyle changes and treatments like statins, PCSK9 inhibitors, and emerging clinical trial therapies. Discover how understanding and managing LDL cholesterol levels can help reduce the burden of this preventable yet most deadly condition.Share with a friend. Rate...
2025-01-2005 minMedEvidence ArticlesFrom Trials to Triumph: 2024’s FDA approvalsJoin us this week for a brief tour of some body systems as we review five medications approved by the FDA in 2024. From liver disease to Alzheimer’s, we look at Rezdiffra, Iqirvo, Vafseo, Entyvio, and Kisunla, exploring the diseases they intend to treat and a brief overview of how the medicines work. We celebrate the hard work of volunteers, investigators, coordinators, and other participants in the clinical trial process.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:
2025-01-1707 minMedEvidence ArticlesShedding Light on Seasonal DepressionIn this episode, we delve into the complexities of Seasonal Affective Disorder (SAD), a subtype of Major Depressive Disorder that fluctuates with the seasons. Seasonal Affective Disorder, a condition affecting millions during the darker months. We explore its symptoms, causes, and demographic prevalence, highlighting its impact on mood, cognition, and physical health. The episode also examines leading theories behind SAD, such as disruptions in circadian rhythms and hormonal imbalances linked to reduced sunlight exposure, and the biological underpinnings. We then move to existing treatment options, including light therapy and cognitive behavioral therapy. With limited clinical trials, the episode underscores...
2025-01-1305 minMedEvidence ArticlesMigraine vs. Komodo Dragon: A Battle of Headache ProportionsThis week we discuss episodic and chronic migraines. Migraines are primary headaches that affect about a billion people globally each year. In this weeks episode, we discuss symptoms and the differences between episodic and chronic migraines. Learn about risk factors, treatment options, and why accurate and appropriate treatment is critical to keep episodic migraines from getting worse.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutube
2025-01-0705 minMedEvidence ArticlesNo Gym, No Problem: Making Fitness Work for YouThis podcast episode examines the challenges of sticking to fitness resolutions and how to make exercise more accessible and sustainable. We discuss the health benefits of physical activity, the impact of stress on the body, and why reducing barriers like time, cost, and convenience can improve consistency. Learn practical tips for incorporating fitness into your routine, including effective home-based exercises and strategies to stay motivated throughout the year.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.Follow us on...
2024-12-3006 minMedEvidence ArticlesWill the Science of Exosomes Revolutionize Medicine?This week, we dive into the fascinating world of exosomes, the body’s nano-sized delivery drivers and communication hubs. We’ll explore what exosomes are, their role in cell-to-cell communication and healing, and the potential medical applications they offer. These include drug delivery, regenerative medicine, and combating diseases like cancer and viral infections. We’ll also discuss the challenges scientists face in harnessing exosomes for safe and effective therapies and why clinical trials are essential in uncovering their true potential. Tune in to learn how these tiny biological packages could shape the future of medicine. Share with a frien...
2024-12-2305 minMedEvidence ArticlesAre You Treating Your Sinus Headache All Wrong?Sinus headaches are annoying, bothersome, and might not really be sinus-related for most people! We look at research that explains why sinus inflammation is rarely the cause headaches above the sinuses and how accurate diagnosis is essential for effective treatment. Learn about the role of sinuses, why facial pain isn’t always what it seems, and how evidence-based approaches like antimigraine medications can bring lasting relief.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical re...
2024-12-0204 minMedEvidence ArticlesLipoprotein (a): The Cholesterol You Inherit, Not EatAs we approach Thanksgiving and gather with family, it's the perfect time to ponder how our genetics, from eye color to cholesterol levels, shape our lives in unique and sometimes dangerous ways. This episode sheds explores how genetic disorders run in families and looks at lipoprotein (a), a very very very very bad kind of cholesterol. We also learn how to get a free cholesterol check that can identify high levels of this dangerous genetic cholesterol which affects up to 20% of the population through cholesterolconnect.comShare with a friend. Rate, Review, and Subscribe to MedEvidence Articles...
2024-11-2507 minMedEvidence ArticlesStatins Good or Bad: Why the Popularity of Cholesterol-Lowering Drugs Sparks CriticismIn this episode we unpack the facts, controversies, and benefits surrounding the most prescribed drugs for lowering “bad” LDL cholesterol. Statins reduce risks of heart attack, stroke, and cardiovascular death, yet concerns over side effects - like muscle pain and blood sugar increases - fuel debates around their use. We’ll explore how statins work, the reality behind their reported side effects, and how lifestyle changes can boost their effectiveness. Join us as we dive into why statins have earned a top spot in heart health and what makes them a critical part of modern medicine. Share with a...
2024-11-1807 minMedEvidence ArticlesThe Physical and Mental Toll of PTSDIn this week's episode we explore how trauma affects many system in the body, with symptoms that can last years or even decades. PTSD impacts not only mental health but also physical health, causing chronic stress that can lead to cardiovascular issues, metabolic changes, and immune dysfunction. We’ll break down the science behind stress responses like allostatic load, which disrupts our body’s ability to adapt and recover, and dive into effective treatments, from trauma-focused talk therapies to new research on psychedelic-assisted therapies. Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notif...
2024-11-1106 minMedEvidence ArticlesIs Inflammation the Fire That Fuels Kidney and Heart Disease?In this week's episode we dive into how chronic inflammation connects kidney disease with cardiovascular risk. Learn how inflammation, typically the body’s healing response, can become a destructive force when it lingers, contributing to kidney damage and cardiovascular issues like high blood pressure and artery hardening. We’ll also explore why CKD patients are often underserved in cardiovascular treatment and how emerging research aims to bridge that gap. Join us to understand the vital role inflammation plays in these two essential systems and what’s being done to manage it. Share with a friend. Rate, R...
2024-11-0405 minMedEvidence ArticlesDoes Intermittent Fasting Really Work – Or Is It Just About Eating Less?This week we explore the science behind one of an increasingly popular approach to managing weight and health—intermittent fasting. We'll break down how limiting your eating window can influence everything from metabolism and inflammation to blood sugar control. With new research showing potential benefits like weight loss and improved glucose levels, we'll also examine what factors may lead to intermittent fasting’s positive effects. Tune in to discover the real impact of this eating pattern and if it’s a sustainable approach to better health!Share with a friend. Rate, Review, and Subscribe to MedEvidence Articl...
2024-10-2905 minMedEvidence ArticlesCan an Inflammation Blood Test Detect Heart Disease Early?In this week's episode we take a closer look at the high-sensitivity C-reactive protein (hs-CRP) test, a powerful tool which may help assess cardiovascular risk. It is a biomarker of inflammation, and hs-CRP’s ability to predict heart disease is both fascinating and complex. We’ll explore how chronic inflammation affects the heart, what high hs-CRP levels can reveal about your health, and how lifestyle and medical changes like exercise and statins can help lower your risk.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.
2024-10-2105 minMedEvidence ArticlesCat Naps and Calories: Uncovering the Link Between Sleep and WeightIn this episode we explore the surprising link between sleep deprivation and weight gain. Discover how hormones like leptin and ghrelin, which regulate hunger and metabolism, are thrown off balance when we don't get enough sleep. We'll break down the science behind why losing sleep can lead to increased hunger, stress eating, and obesity, and how even a catnap can help restore balance. Tune in to learn why a good night's sleep is not just refreshing for your brain, but essential for your gut health and overall well-being. Share with a friend. Rate, Review, and Subscribe to M...
2024-10-1405 minMedEvidence ArticlesWhat is High-Density Lipoprotein (HDL)?In this episode we explore the vital role that HDL cholesterol plays in maintaining cardiovascular health. Known as "good cholesterol," HDL helps clear excess fats from the bloodstream, but recent research shows that its role is far more complex than we once thought. We'll discuss how low HDL levels are linked to increased heart disease risk, why simply raising HDL numbers might not be enough, and how lifestyle changes can improve both the quantity and quality of this important molecule. Tune in to learn about the evolving science behind HDL and what it means for your heart health!
2024-10-0706 minMedEvidence ArticlesCan We Outsmart Viruses by Targeting Their Shared Weakness?In this episode, we take a microscopic look at how some of the most dangerous RNA viruses, like COVID-19, Ebola, RSV, and the flu, hijack our cells to replicate. Discover the science behind viral reproduction and RNA-dependent RNA polymerase, the specialized machinery these viruses rely on. We’ll also explore how new antiviral treatments based on Remdesivir are being developed to target this shared vulnerability, offering hope for fighting multiple viruses with a single strategy. Join us for a fascinating dive into the microscopic world of viruses and cutting-edge medical research.Participate in clinical research!
2024-09-3004 minMedEvidence ArticlesIs Your Chronic Cough an Unwelcome House Guest?This week we dive deep into the mysteries of chronic cough—a condition that affects millions worldwide and can last for months or even years. In this episode, we’ll explore the science behind why we cough, how chronic cough disrupts lives, and the latest research on treatments and potential cures. From overactive nerve responses to underlying health conditions, we break down the complexities of this frustrating ailment.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when...
2024-09-2305 minMedEvidence ArticlesMetabolic Syndrome: A New HopeIn this episode, we compare the looming disaster of the Death Star to the health risks of Metabolic Syndrome, a combination of factors that significantly increase the chances of serious conditions like diabetes, heart disease, and stroke. Just as the Death Star’s vulnerability came from multiple issues working together, Metabolic Syndrome results from a dangerous mix of obesity, high blood pressure, high blood sugar, and more. We’ll explore how these factors interact, the key to managing the condition through lifestyle changes, and how clinical research may help turn the tide.Participate in clinical research!
2024-09-1606 minMedEvidence ArticlesAsthma: From Trigger to TreatmentIn this week's episode, we’re using a historical naval mishap as a metaphor to explain how asthma works. Much like the Spanish ships accidentally firing on their own allies in 1801, asthma is caused by your immune system misfiring—targeting harmless particles like dust or allergens and causing inflammation in your airways. We’ll dive into the mechanics of asthma, explore the role of the immune system’s cytokines and white blood cells, and look at the latest treatments and research aimed at calming this immune overreaction.Participate in clinical research!www.ENCOREdocs.com
2024-09-0906 minMedEvidence ArticlesObservations on Autosomal Dominant Polycystic Kidney DiseaseIn this episode, we delve into the fascinating world of kidneys, those incredible organs that tirelessly filter our blood and regulate our body’s fluids. We’ll explore the complexities of autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that affects a small percentage of the population but can lead to severe outcomes like kidney failure. Join us as we uncover the latest research, including how animal studies and genetic analysis are helping scientists understand the mechanisms behind this disease. We’ll also discuss the ongoing efforts to find effective treatments and the crucial role of clinical research in adv...
2024-09-0206 minMedEvidence ArticlesThe "Flu Fighters": Unusual Remedies from HistoryIn this episode, we explore the fascinating history of flu treatments, from bizarre and dangerous remedies of the past to the cutting-edge vaccines of today. We'll dive into the strange and often misguided methods used before the modern era, including addictive drugs, oysters, chloroform, and even chemical warfare agents. As we move into modern times, we'll discuss how vaccines, and newer medications have revolutionized flu prevention. Join us as we journey through the wild evolution of flu treatments and look ahead to the future of viral medicine. Participate in clinical research!www.ENCOREdocs.com
2024-08-2606 minMedEvidence ArticlesNorovirus: Stomach Flu Spreading Like Room-Temperature ButterIn this episode, we delve into the gritty details of the stomach flu, focusing on the notorious Norovirus (stomach bug). Once overshadowed by Rotavirus, Norovirus now leads the charge in causing widespread acute gastroenteritis across all ages. We'll explore its symptoms, transmission, and why it thrives in closed environments like schools and cruise ships. Discover the surprising resilience of this virus, how it spreads with ease, and the ongoing clinical trials striving to develop a vaccine. Tune in to understand the battle against this stubborn bug and the efforts to protect vulnerable populations from its reach. ...
2024-08-1904 minMedEvidence ArticlesElevated Lipoprotein(a): Causes, Risks, and Management StrategiesIn this episode, we dive deep into the world of lipids and their crucial role in our bodies. Lipids, or fats, are essential for many bodily functions but pose a challenge when circulating in our watery bloodstream. We explore how the body packages these lipids with apolipoproteins to form lipoproteins, making them safe for transport. We discuss the differences between high-density lipoprotein (HDL), low-density lipoprotein (LDL), and the particularly harmful lipoprotein(a) or Lp(a). Discover the factors influencing Lp(a) levels and the dangers of high Lp(a), including plaque buildup, blood clots, and inflammation. Learn about current...
2024-08-1206 minMedEvidence ArticlesCan Cannabis Cancel Migraines?Curious about cannabis and migraines? In this episode, we explore the intriguing connection between the two. Discover how cannabis, historically used for headache relief, is making a comeback in medical circles despite legal hurdles. We dive into the endocannabinoid system, THC, CBD, and their potential impacts on migraine pathways. Learn about the latest research, including a groundbreaking clinical trial published in Neurology, and what it reveals about cannabis as a treatment for migraine pain. Tune in to uncover the science, history, and future possibilities of using cannabis to combat migraines.Participate in clinical research!...
2024-08-0507 minMedEvidence ArticlesA Trip Down Memory LaneJoin us as we dive into the complexities of memory and its fascinating mechanisms. We'll explore the different types of memory, how they're formed, stored, and retrieved, and the various brain regions involved. Discover the stark differences between implicit and explicit memory, and learn why conditions like Alzheimer's and other forms of dementia disrupt these processes, leading to devastating memory loss. We'll also discuss practical steps to reduce the risk of memory loss, from lifestyle changes to early interventions. Tune in to unravel the mysteries of memory and understand how we can protect it for a healthier future.
2024-07-1506 minMedEvidence ArticlesEye-Opening Facts About BlepharitisIn this episode, we dive into the world of blepharitis, a common yet often misunderstood condition that causes inflammation of the eyelids. Affecting people of all ages and backgrounds, blepharitis leads to symptoms such as eye irritation, redness, swelling, and dryness, significantly impacting quality of life. We'll explore the various causes, including bacterial infections, gland dysfunction, and even mites, and discuss the challenges of diagnosing and treating this multifaceted disorder. From simple home remedies to advanced medical treatments, join us as we uncover the best strategies for managing blepharitis and maintaining healthy, comfortable eyes. Participate in...
2024-07-0805 minMedEvidence ArticlesDiabetes From Your Head to Your ToesIn this episode, we dive deep into the complexities of diabetes beyond just managing blood sugar levels. Learn how uncontrolled diabetes impacts several parts of the body, causing serious complications due to blood vessel damage. We'll explore microvascular complications like diabetic retinopathy and nephropathy, as well as macrovascular issues such as heart disease and stroke. Discover the importance of managing diabetes through lifestyle changes and medications, and hear about therapies and outcomes for those living with this challenging condition. Tune in to understand the full scope of diabetes and how to tackle its complications. Participate in c...
2024-07-0103 minMedEvidence ArticlesRheum for Improvement Tackling Rheumatoid ArthritisIn this episode, we explore the complexities of rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease affecting millions worldwide. RA causes the immune system to attack healthy joint tissue, leading to pain, stiffness, swelling, and serious complications such as joint and bone damage, and organ issues. We'll discuss the factors contributing to RA, its impact on daily life, and the various treatment options available. Join us to understand how to manage and seek relief from this debilitating disease. Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and S...
2024-06-2805 minMedEvidence ArticlesMigraines: Are They More Than a Headache? In this episode, we explore the intricate world of migraines, a condition affecting one in eight people globally. Discover the five phases of a migraine—prodrome, aura, headache, postdrome, and interictal—and how each contributes to the overall experience. We delve into the role of the hypothalamus, the brain's stability center, in triggering migraines and the various symptoms it causes. Learn about potential triggers, the pain pathways involved, and effective relief methods. Tune in to understand migraines better and find ways to manage this disabling condition. Participate in clinical research!www.ENCOREdocs.comS...
2024-06-2707 minMedEvidence ArticlesInhale, Exhale, Repeat: Understanding COPDIn today's episode, we delve into Chronic Obstructive Pulmonary Disease (COPD), a debilitating lung condition affecting millions worldwide. Characterized by obstructed airflow, COPD's symptoms—ranging from persistent cough and phlegm to life-threatening exacerbations—stem from the progressive degradation of lung structure. This disease is exacerbated by factors like smoking, air pollution, and exposure to occupational hazards like dust and chemicals. With a look at the lung's anatomy, from the macroscopic airways down to the microscopic alveoli, we explore how chronic inflammation and emphysema reduce lung function over time, making every breath a challenge. We also cover strategies to mitigate dama...
2024-06-1007 minMedEvidence ArticlesWhich Animal Is the Deadliest to Humans?In today's episode, we dive into the surprisingly nuanced world of mosquitoes, revealing their role as the deadliest animal on Earth due to their capacity as disease vectors. While shark attacks capture headlines, mosquitoes quietly claim up to a million lives annually by transmitting diseases like malaria, dengue, and yellow fever. We explore the mechanics of how mosquitoes locate their hosts and cover various attractants and deterrents, debunking myths around natural repellents while highlighting the limited effectiveness of common strategies like dietary changes. Ultimately, perhaps the most promising avenue to mitigate their deadly impact lies in advancing medical research...
2024-06-0309 minMedEvidence ArticlesHow Did the Tuskegee Study Influence Modern Research Ethics?This week's podcast dives into the harrowing legacy of the Tuskegee syphilis study, a dark chapter in American history that began in 1932. This study blatantly ignored ethical principles that and represented a grievous lapse in justice, respect, and beneficence in clinical research. The exposure of this unethical experiment in the 1970s led to significant reforms, including the Belmont Report which set forth strict guidelines for human subjects' protection, emphasizing informed consent, risk/benefit assessment, and equitable subject selection. These measures were designed to ensure that the tragedies of the Tuskegee study would never be repeated, mandating a clear demarcation...
2024-05-2909 minMedEvidence ArticlesR.E.S.P.E.C.T. In ResearchThis podcast explores the evolution of ethical standards in clinical research, highlighted by the Declaration of Helsinki. Initially drafted in response to historical abuses, the Declaration enforces principles ensuring patient well-being, informed consent, and fair treatment across studies. It mandates transparency in protocol, independent reviews, and public reporting to uphold respect, beneficence, and justice in medical trials. The episode underscores the significance of these guidelines in safeguarding human participants and shaping a more ethical landscape in medical research.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and...
2024-05-2005 minMedEvidence ArticlesWhat Is Diabetic Gastroparesis and How Does Diabetes Affect Digestion?Today we delve into the intricate relationship between diabetes and gastrointestinal health, focusing on a condition known as gastroparesis. Gastroparesis slows down the stomach's ability to empty food, a condition exacerbated by diabetes. The episode explores how diabetes disrupts the normal functioning of the enteric nervous system—our body's "second brain" that governs gut movements. This system, rich with neurons and interstitial cells of Cajal, orchestrates the rhythmic contractions of the gut's smooth muscles but is vulnerable to the high blood sugars characteristic of uncontrolled diabetes. The resultant neuronal damage and impaired muscle function slow stomach and intestinal transit, co...
2024-05-0805 minMedEvidence ArticlesWhat's Keeping a Billion People Up at Night?Explore the world of breathing and its complications in this podcast, where we delve into the surprisingly complex mechanism of breathing and the common but often unrecognized condition of obstructive sleep apnea (OSA). Affecting approximately one billion people globally, OSA disrupts sleep by blocking the airway, leading to snoring, restless nights, and dangerous daytime sleepiness. We'll uncover how the body's failure to keep the throat muscles firm during sleep, combined with factors like body position and structural anomalies in the airway, contribute to this condition. Furthermore, we discuss the roll excess weight can play on . Join us as we...
2024-05-0604 minMedEvidence ArticlesWill Gut Microbiome Transplants Lead to New Treatments for Ulcerative Colitis?In this podcast episode, we explore the crucial role of the gut microbiome, a complex ecosystem within us composed primarily of bacteria that perform essential functions for our health. We discuss how the microbiome influences everything from nutrient absorption to immune response and how its imbalance leads to conditions like ulcerative colitis. Highlighting cutting-edge research, we delve into the potential of fecal transplants and dietary changes to restore gut health. This fascinating journey into our internal universe underscores the importance of maintaining microbial diversity for overall well-being and paves the way for innovative treatments in gastrointestinal health.
2024-04-2506 minMedEvidence ArticlesPacing the Path to Healthy Blood PressureThis podcast delves into the prevalent issue of high blood pressure, a condition impacting nearly half of all Americans and contributing to severe health complications like heart attacks and strokes. Despite numerous available medications, many patients struggle with treatment effectiveness and adherence. The episode explores an innovative approach targeting the heart's role in blood pressure regulation through the Frank-Starling law, which explains how the heart's stretch before each beat affects blood pressure. Highlighting cutting-edge research on pacemakers, it discusses how these devices might be reprogrammed to not only manage arrhythmias but also effectively reduce blood pressure by optimizing heart...
2024-04-2205 minMedEvidence ArticlesShedding Light On Vitamin DIn this enlightening episode, we delve into the pivotal role of sunlight and its influence on our health, focusing on Vitamin D production. Despite widespread belief in the benefits of Vitamin D supplements, research reveals a complex reality. While supplementation does increase Vitamin D levels in the blood, it often fails to alleviate associated health issues, suggesting that underlying conditions affecting Vitamin D synthesis may be the culprits. Observational studies highlight correlations between Vitamin D deficiency and various health problems, but clinical trials suggest these issues are not directly resolved by supplementation. The narrative challenges common misconceptions, emphasizing the...
2024-04-1605 minMedEvidence ArticlesGetting Hyper-Fixated on HypothyroidismIn this podcast, we unravel the intricacies of thyroid function and delve into the complexities of hypothyroidism, a condition marked by insufficient thyroid hormone production. The thyroid gland, nestled in the neck and resembling a butterfly, plays a pivotal role in regulating metabolic processes through the synthesis and release of hormones such as thyroxine (T4) and triiodothyronine (T3). Hypothyroidism, with its diverse etiologies including autoimmune thyroiditis and iodine deficiency, poses significant health challenges, manifesting in symptoms ranging from fatigue to cardiovascular complications. While levothyroxine remains the cornerstone of treatment, adjunctive therapies such as T3 supplementation and desiccated thyroid extract...
2024-04-0807 minMedEvidence ArticlesThe Effectiveness of Duct Tape in Fixing Broken HeartsThis April 1st we’re taking a satirical look at manual heart repair using a woven-material-backed pressure sensitive tape.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.comThank yo...
2024-04-0104 minMedEvidence ArticlesThe Woman Who Pioneered Diabetes ResearchIn this Women’s History Month special, we delve into the extraordinary life and groundbreaking work of Dr. Gerty Cori, the first American woman to win a Nobel Prize in Physiology or Medicine. Born into a Jewish family in Prague in 1896, Gerty overcame societal barriers to become a pioneering researcher alongside her husband, Carl Cori. Their collaborative efforts led to significant discoveries in glucose metabolism, including the elucidation of the Cori Cycle, a pivotal mechanism explaining how the body generates energy during intense exercise. Despite facing gender discrimination in academia, Gerty's perseverance and brilliance earned her and Carl the No...
2024-03-2704 minMedEvidence ArticlesLp(a), the Little Hellfire Engine That Could (Kill You)In this episode, we embark on a journey through the intricate highways of the bloodstream, exploring the fascinating world of lipoproteins. These ingenious packages, comprised of lipids and proteins, navigate the watery terrain of blood, ferrying essential nutrients and molecules like cholesterol to cells throughout the body. But our adventure takes a dark turn as we encounter the menacing Lp(a), a variant of lipoprotein with the potential to wreak havoc on the cardiovascular system. As we navigate the complexities of high Lp(a) levels and their genetic underpinnings, we illuminate the ongoing quest for innovative treatments and the...
2024-03-2007 minMedEvidence ArticlesAdult Acne Really Gets Under My SkinWelcome to our latest podcast episode where we peel back the layers of adult acne, diving deep into the science behind this common yet often misunderstood skin condition. From the humble beginnings of puberty to the complex factors contributing to acne formation, we explore the journey from zits to treatments. Join us as we dissect the role of sebaceous glands, the impact of hormonal imbalances, and the microbial mayhem within our skin microbiome. With insights into the latest treatments, including topical agents and systemic therapies, we navigate the path towards clearer skin and improved confidence. Tune in for a...
2024-03-1307 minMedEvidence ArticlesWhat Is Chronic Kidney Disease?Delve into the intricate world of kidney function and the complexities of chronic kidney disease (CKD) in our latest episode, where we unravel the fascinating mechanisms behind how kidneys filter blood several times a day. From nephrons to glomeruli and podocytes, we explore the vital role played by these microscopic structures. With over 13% of the global population affected, including 37 million Americans, CKD poses a significant public health challenge, progressing silently in its early stages and wreaking havoc on health, particularly the cardiovascular system, in advanced cases. Unraveling the causes of CKD reveals a mix of modifiable and non-modifiable risks, from...
2024-03-0607 minMedEvidence ArticlesWho Knew Hand Washing Could Be So DangerousExplore the remarkable journey of Dr. Ignaz Semmelweis, an unsung hero of public health whose advocacy for hand hygiene in 19th-century maternity wards sparked a medical revolution. Our latest episode delves into Semmelweis's story, from his groundbreaking efforts that saved countless lives to the tragic consequences he faced. Join us as we uncover the captivating tale of a visionary whose ideas were ahead of his time, leaving a lasting legacy in every wash and scrub.Participate in clinical research!www.ENCOREdocs.comShare with a friend. Rate, Review, and Subscribe...
2024-02-2807 minMedEvidence ArticlesThe Obesity SpiralShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutube For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com Thank you for listening!
2023-04-0306 minMedEvidence ArticlesThe “Spanish Flu” of 1918Dive into the history of the worst flu outbreak known; the "Spanish Flu" of 1918. We explore the background and effects of this disease and why the name is neither accurate nor fair to the Spanish.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released. Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutube For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.com ...
2022-10-1003 min