Shows
MedEvidence ArticlesThe Brain's Worst Hit: Understanding Traumatic Brain InjuryOn this week's episode, written by guest author Christy Kestner, PhD, we discuss traumatic brain injury; when the brain gets banged around enough to cause damage. We explore the causes, problems, some ways to protect yourself, and what to do if you or someone you know experiences a traumatic brain injury; along with signs and symptoms to help identify one.2025-07-2806 minMedEvidence ArticlesHow Inflammation Threatens Your Kidneys and HeartChronic kidney disease (CKD) is incredibly common, affecting 1 in 7 Americans, and heart disease is a common cause of death for those with CKD. In this week's article we explore the role inflammation plays in chronic kidney disease and how the same inflammation that damages the kidneys may also lead to damage in other parts of the body, including the heart. We also review why inflammation is beneficial in low amounts and what's being done to help lower chronic inflammation without compromising this vital immune response.2025-07-2107 minMedEvidence ArticlesSteering Treatments for Major Depressive DisorderIn this week's episode we review Major Depressive Disorder, a common mental disorder affecting millions of Americans. We explore who this disorder affects, what happens in the brain and body, and what treatments are available. We also get into the psychadellic substance psilocybin (psylocin) and how this breakthrough therapy may help those with Major Depressive Disorder.2025-07-1406 minMedEvidence ArticlesBeneath the Surface of Hidradenitis SuppurativaIn this week's episode, we explore the chronic inflammatory skin condition Hidradenitis Suppurativa (HS). With HS, hair follicles located in large skin creases like the armpits become inflamed and clogged. The units, called the pilosebaceous unit, fill with puss, rupture, and cause a host of problems for sufferers. We investigate what hidradenitis suppurativa is, who it affects, what goes wrong in the body, and what's being done about it2025-07-0705 minMedEvidence ArticlesDehydration Isn't a Day at the BeachIn this episode we review what happens in dehydrtion, who may be at increased risk, and what happens to the body when it doesn't get enoug hwater. We also distinguish between two major types of dehydration; intracellular (without salt loss) and extracellular (with salt loss). Learn all about how this summer condition can lead to problems that feel as dangerous as being marooned on a desert isle!2025-06-3006 minMedEvidence ArticlesThe Cost of Extra Weight on Heart Failure RiskThis week, we investigate the links between heart failure and obesity. We explore what heart failure is, the risks, and how it can have long-term impacts on health. We also look into obesity, some of it's causes, and how it can contribute to heart failure risks. We also look at he two-way street between heart failure and obesty and how each can contribute to the other in a feedback loop, and what may be done to break it.2025-06-2305 minMedEvidence Articles85–90% of Primary Liver Cancers Are Hepatocellular Carcinoma, Why Aren’t We Catching It Sooner?Hepatocellular Carcinoma (HCC) is the most common cause of primary liver cancer. Curative treatments include surgery and transplant, but many patients don't know they have the disease until it's too late. In this week's article, we explore what HCC is, risks and complications of the disease, and what people can do to find out if they have signs of the HCC before it spreads too far.2025-06-1606 minMedEvidence ArticlesFrom Cross-Contamination to Cure: Hepatitis CIn this week's episode, we look into the history of Hepatitis C. The hepatitis C virus spread far and wide during the era before modern sterilization and screening, infecting millions. We look into the history, risks, symptoms (many have none!), and complications of hepatitis C. Finally, we look at how far treatment has progressed and what's coming up on the horizon.2025-06-1205 minMedEvidence ArticlesSpeaking About Social Anxiety DisorderIn this episode, we delve into the science and struggle behind social anxiety disorder. This condition affects millions of people and often begins in childhood. We explore how the brain’s fear circuitry becomes overactive, and common treatments like SSRIs. We also highlight an intriguing new treatment being tested: a nasal spray of pheromone-like compounds aimed at calming fear responses.2025-05-2705 minMedEvidence ArticlesGastroparesis Turns Meals into MiseryIn this episode, we explore the complex world of gastroparesis. Gastroparesis is a condition that slows the stomach’s ability to empty food and turns mealtime into a daily challenge. From the science behind digestion to the symptoms, causes, and evolving treatments for idiopathic gastroparesis, we break down what happens when the stomach stops cooperating. Learn how this disorder affects quality of life and what new therapies would look like to help people enjoy food again without the side effects.2025-05-2103 minMedEvidence ArticlesWhen Life Gives You Limes, Solve ScurvyScurvy, a disease caused by vitamin C deficiency, once killed thousands of sailors during long sea voyages. The breakthrough came in 1747 when Dr. James Lind conducted the first recorded clinical trial, proving citrus fruits could prevent the illness. British sailors were later issued lime juice, earning them the nickname “limeys.” Though now considered offensive by some, the term reflects an important medical milestone and the early use of evidence-based treatment. 2025-05-1605 minMedEvidence ArticlesTinnitus Treatments Result From Clinical TrialsThis week we explore tinnitus, a condition marked by ringing in the ears. Tinnitus is affects roughly 10% of Americans and remains poorly understood. Unfortunately, this poor understanding means there are no disease-modifying treatments available. Luckily, clinical researchers have been hard at work looking for relief for tinnitus sufferers, and there are some symptomatic treatments. Listen in to find out what tinnitus is, risks and complications, and some ways you may be able t ofind relief.2025-05-1204 minMedEvidence ArticlesCan We Train the Immune System to Kill Cancer?In this week's episode, we jump into the emerging field of personalized cancer vaccines. Cancer remains the second leading cause of death worldwide due to its complex nature. "Cancer" actually encompasses over 275 diseases, each driven by genetic mutations that make cancer cells act independently and harmfully within the body. Find out how scientists are using genetics to identify unique targets for individual people's cancers and using these targets to train our own immune system using cancer vacines.2025-05-0504 minMedEvidence ArticlesVascular Dementia: Causes, Symptoms, Risk Factors, and Treatment OptionsIn this week's episode, we talk about vascular dementia, a significant yet often overlooked brain disorder caused by reduced blood flow, usually due to stroke and/or vascular disease. It accounts for 15-20% of dementia cases and leads to cognitive decline, memory loss, and motor impairments. While no cure exists, prevention is key—controlling risk factors like high blood pressure, diabetes, and smoking can significantly reduce the likelihood of developing the disease. Research suggests that physical fitness offers strong protective benefits, and some Alzheimer’s medications may provide limited relief. Continued clinical trials are essential in the search for effe...2025-04-2803 minMedEvidence ArticlesWhy Measles Has Gone From Eradicated To OutbreakMeasles a highly contagious virus that can cause serious complications, including pneumonia, brain swelling, and death. It was declared eradicated in the U.S. in the year 2000 but has resurfaced, with over 700 cases reported so far this year. What are the causes of this latest outbreak? Despite a long history of vaccine success, recent declines in MMR vaccination rates have made populations vulnerable again. Historically, vaccination efforts drastically reduced measles cases, but global travel and misinformation now threaten that progress. Listen now to find out the facts, history, and factors contributing to the currentmeasles outbreak in the U.S.2025-04-2106 minMedEvidence ArticlesPsoriasis and the Immune System: More Confusing Than Teenage SlangOn this week, we discuss psoriasis, a chronic autoimmune disease affecting 2-3% of Americans. It's characterized by red, flaky skin and linked to serious health conditions like arthritis and cardiovascular disease. It results from an overactive immune response which may be initiated or worsened by environmental factors such as stress, obesity, and smoking. Inside the body, immune molecules -including T helper cells, interleukins, and TYK2 - are overactive and lead to excessive skin cell production. Medications for moderate to severe psoriasis target these immune molecules, though more clinical trials are needed to balance with effectiveness with side effects.2025-04-1405 minMedEvidence ArticlesClinical Trials Have Opened Doors to COPD MedicationsIn this week we talk about chronic obstructive pulmonary disease (COPD), a progressive lung condition that restricts airflow due to chronic bronchitis and emphysema, which damages the alveoli. COPD affects around 11% of adults over 30 and is linked to smoking, pollution, and genetic factors. This episode relates COPD to a house with big rooms and narrow doors, making furnishing a challenge, and fives into the mechanisms, symptoms, and treatments for the disease.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released....2025-04-0706 minMedEvidence ArticlesA New Type of Memory Loss in Older AdultsThis podcast explores Limbic-predominant Amnestic Neurodegenerative Syndrome (LANS), a newly identified condition that primarily affects episodic memory while leaving other cognitive functions relatively intact. LANS is associated with the misfolding of TDP-43, a protein that can accumulate and damage limbic structures. Unlike Alzheimer’s, LANS has a slower onset and lacks definitive diagnostic tests, making research critical for future treatments. With the aging population, understanding and addressing LANS could become as significant as Alzheimer’s research. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are relea...2025-03-3105 minMedEvidence ArticlesAlzheimer’s at the Genetic LevelMedical treatments are shifting from broad approaches to precise genetic targeting, especially for finicky diseases like Alzheimer's dementia. While many past efforts focused on amyloid β plaques, new research is exploring genetic regulators like APP, which influences amyloid levels, and KDM5, an enzyme linked to memory and cognition. Clinical trials are testing drugs that could balance these proteins and potentially slow cognitive decline at its root. Tune in this week for a deep look into the genetics of Alzheimer'sShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are r...2025-03-2405 minMedEvidence ArticlesDigging Up the Truth About PotatoesThis St. Patrick's Day we explore the history, nutritional profile, and potential health benefits of potatoes. Potatoes are a major global food staple, providing significant calories worldwide. Though often criticized for their high glycemic index (GI), different cooking methods, particularly chilling after cooking, can increase resistant starches, which improve gut health and reduce blood sugar impact. Potatoes also have a high satiety index, making them more filling than many other foods. While long-term clinical studies are needed, current epidemiological data suggest that potatoes are not linked to negative health outcomes—unless consumed as french fries. 2025-03-1705 minMedEvidence ArticlesWhat are Cluster Headaches?In this week's episode, we discuss cluster headaches, one of the most severe pain conditions known. This rare condition affects about one in a thousand people with excruciating, clockwork-like attacks can last for weeks or months, with few effective treatment options. In this episode, we break down the causes, triggers, and latest research on cluster headaches, from abortive therapies like oxygen and triptans to emerging neuromodulation treatments.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:Facebook2025-03-1006 minMedEvidence ArticlesAlzheimer’s Anxiety: What’s Normal, What’s Not, and When to ActForgetting a name or misplacing your keys can be frustrating, but when does memory loss signal something more serious? In this episode, we explain the key differences between normal aging and Alzheimer’s disease. We break down how doctors diagnose Alzheimer’s, the role of biomarkers, and why early detection is crucial for those considering clinical trials.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTikt...2025-03-0303 minMedEvidence ArticlesNew Research on Heart Failure: Understanding IL-6 and InflammationThis week, we talk about one of the big contributors to heart failure: inflammation. Heart failure affects millions and comes in two main types: HFrEF (weakened pumping) and HFpEF (thickened, stiff walls). While conditions like high blood pressure and diabetes contribute, chronic inflammation—driven in part by Interleukin 6 (IL-6)—plays a major role. IL-6 causes muscle damage, fibrosis, and worsens other diseases. Researchers are developing monoclonal antibodies to regulate IL-6, offering a potential breakthrough technology in reducing inflammation and improving heart health. Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when...2025-02-2104 minMedEvidence ArticlesShort Circuits in the Heart: A Look at Atrial FibrillationWhen the hot water went out, you might call a plumber, but if the water heater is out it might instead be an electrical problem - just like how heart problems can stem from faulty electrical signals rather than the heart muscle itself. Atrial fibrillation (AFib), the most common arrhythmia affecting six million Americans, disrupts the heart’s electrical system, causing rapid, chaotic beating that increases stroke risk fivefold. In this week's episode, we review AFib, the risk factors to develop it, symptoms , how it happens, and treatments. Water you waiting for, listen today!Share with a...2025-02-1005 minMedEvidence ArticlesThe Heart is the Beat of LifeThis week's podcast is a crash course on what the heart is, why we need it, how it works, and what can go wrong.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! podcast. www.MedEvidence.comThank you for listening!2025-02-0304 minMedEvidence ArticlesAlzheimer’s and ADHD, the Missing Link?This week we talk about two recent studies which suggest a potential link between adult ADHD and an increased risk of developing dementia; though causation remains unproven. These studies, one in Israel and another in Sweden, found that adults with ADHD were significantly more likely to develop dementia or mild cognitive impairment. These findings were consistent across most demographics, though ADHD medication appeared to reduce the risk. The research highlights the need for further exploration into shared mechanisms between these conditions and raises questions about whether ADHD may predispose the brain to dementia or if certain factors, such as...2025-01-2706 minMedEvidence ArticlesShiny Legs, Hidden DangerThis week we discuss peripheral artery disease (PAD), a condition affecting blood flow in the peripheral arteries, most commonly in the legs. We cover its symptoms, such as leg pain, skin changes, and slow-healing wounds, as well as the potential risks of untreated PAD, including amputation and cardiovascular complications. We then talk about treatment options, including medications, lifestyle changes, structured exercise programs, and advanced interventions like revascularization.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:Facebook2025-01-2706 min
MedEvidence! Truth Behind the Data🎙 Hero or Villain? Dr. Tony Fauci Speaks with MedEvidence Ep. 260Send us a textJoin Dr. Anthony Fauci and Dr. Michael Koren as they discuss the public health events that have punctuated Dr. Fauci's life. The doctors discuss the difficulties of the HIV epidemic in the 1980's and how Dr. Fauci's early career decision to pursue this emerging threat helped inform and prepare him for the COVID-19 pandemic. Doctors Koren and Fauci wade through the myriad controversies surrounding the public health response to the COVID-19 pandemic; from its origins, the importance of vaccines, and the balance of public health and individual rights. Finally, the two speak about...2025-01-2441 minMedEvidence ArticlesIs the Deadliest Condition Preventable? Understanding ASCVD and LDL-CThis episode explores atherosclerotic cardiovascular disease (ASCVD), the leading cause of heart attacks and strokes worldwide. Learn about the role of LDL cholesterol in the development of fatty plaques that harden and block blood vessels, as well as the risks associated with ASCVD, including heart disease and peripheral artery disease. The episode highlights preventive strategies such as healthy lifestyle changes and treatments like statins, PCSK9 inhibitors, and emerging clinical trial therapies. Discover how understanding and managing LDL cholesterol levels can help reduce the burden of this preventable yet most deadly condition.Share with a friend. Rate...2025-01-2005 minMedEvidence ArticlesFrom Trials to Triumph: 2024’s FDA approvalsJoin us this week for a brief tour of some body systems as we review five medications approved by the FDA in 2024. From liver disease to Alzheimer’s, we look at Rezdiffra, Iqirvo, Vafseo, Entyvio, and Kisunla, exploring the diseases they intend to treat and a brief overview of how the medicines work. We celebrate the hard work of volunteers, investigators, coordinators, and other participants in the clinical trial process.Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:2025-01-1707 minMedEvidence ArticlesShedding Light on Seasonal DepressionIn this episode, we delve into the complexities of Seasonal Affective Disorder (SAD), a subtype of Major Depressive Disorder that fluctuates with the seasons. Seasonal Affective Disorder, a condition affecting millions during the darker months. We explore its symptoms, causes, and demographic prevalence, highlighting its impact on mood, cognition, and physical health. The episode also examines leading theories behind SAD, such as disruptions in circadian rhythms and hormonal imbalances linked to reduced sunlight exposure, and the biological underpinnings. We then move to existing treatment options, including light therapy and cognitive behavioral therapy. With limited clinical trials, the episode underscores...2025-01-1305 minMedEvidence ArticlesMigraine vs. Komodo Dragon: A Battle of Headache ProportionsThis week we discuss episodic and chronic migraines. Migraines are primary headaches that affect about a billion people globally each year. In this weeks episode, we discuss symptoms and the differences between episodic and chronic migraines. Learn about risk factors, treatment options, and why accurate and appropriate treatment is critical to keep episodic migraines from getting worse.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutube2025-01-0705 minMedEvidence ArticlesNo Gym, No Problem: Making Fitness Work for YouThis podcast episode examines the challenges of sticking to fitness resolutions and how to make exercise more accessible and sustainable. We discuss the health benefits of physical activity, the impact of stress on the body, and why reducing barriers like time, cost, and convenience can improve consistency. Learn practical tips for incorporating fitness into your routine, including effective home-based exercises and strategies to stay motivated throughout the year.Share with a friend. Rate, Review, and Subscribe to MedEvidence Articles to be notified when new episodes are released.Follow us on...2024-12-3006 minMedEvidence ArticlesWill the Science of Exosomes Revolutionize Medicine?This week, we dive into the fascinating world of exosomes, the body’s nano-sized delivery drivers and communication hubs. We’ll explore what exosomes are, their role in cell-to-cell communication and healing, and the potential medical applications they offer. These include drug delivery, regenerative medicine, and combating diseases like cancer and viral infections. We’ll also discuss the challenges scientists face in harnessing exosomes for safe and effective therapies and why clinical trials are essential in uncovering their true potential. Tune in to learn how these tiny biological packages could shape the future of medicine. Share with a frien...2024-12-2305 minMedEvidence ArticlesAre You Treating Your Sinus Headache All Wrong?Sinus headaches are annoying, bothersome, and might not really be sinus-related for most people! We look at research that explains why sinus inflammation is rarely the cause headaches above the sinuses and how accurate diagnosis is essential for effective treatment. Learn about the role of sinuses, why facial pain isn’t always what it seems, and how evidence-based approaches like antimigraine medications can bring lasting relief.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical re...2024-12-0204 minMedEvidence ArticlesLipoprotein (a): The Cholesterol You Inherit, Not EatAs we approach Thanksgiving and gather with family, it's the perfect time to ponder how our genetics, from eye color to cholesterol levels, shape our lives in unique and sometimes dangerous ways. This episode sheds explores how genetic disorders run in families and looks at lipoprotein (a), a very very very very bad kind of cholesterol. We also learn how to get a free cholesterol check that can identify high levels of this dangerous genetic cholesterol which affects up to 20% of the population through cholesterolconnect.comShare with a friend. Rate, Review, and Subscribe to MedEvidence Articles...2024-11-2507 minMedEvidence ArticlesStatins Good or Bad: Why the Popularity of Cholesterol-Lowering Drugs Sparks CriticismIn this episode we unpack the facts, controversies, and benefits surrounding the most prescribed drugs for lowering “bad” LDL cholesterol. Statins reduce risks of heart attack, stroke, and cardiovascular death, yet concerns over side effects - like muscle pain and blood sugar increases - fuel debates around their use. We’ll explore how statins work, the reality behind their reported side effects, and how lifestyle changes can boost their effectiveness. Join us as we dive into why statins have earned a top spot in heart health and what makes them a critical part of modern medicine. Share with a...2024-11-1807 min