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Ndea
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The Swerve Podcast: Obscure Topics | Conspiracy Theories
GATE Program Conspiracy: They Tested Us?
They told us we were gifted. They pulled us from class. They tested us behind covered windows. Now thousands of adults are asking the same question: what was that?🔥 Patreon: Consider Supporting + Receive Bonus ContentDid the US government use the Gifted and Talented Education program to identify children for secret experiments?Here, I deep dive the GATE Program conspiracy theories to better understand why thousands of former students report identical, unsettling memories of specialized testing and isolation. We will analyze the alleged connections between public education and covert operations like MKUltra and Project Stargate...
2026-02-18
1h 19
Abstract Synthesis
February 2026 Podcast Recap
Program synthesis is the problem of automatically generating code that satisfies a specification. The real challenge isn’t searching faster, it’s making the right parts of the search space searchable at all.This week's episode is a short recap of the podcast so far. Across the past 8 conversations - spanning grammar filtering, temporal synthesis, inductive logic programming, vision-language programs, and symbolic world models - we explore 3 emergent themes.1. Shrinking the search space, without breaking correctness2. Why "correct" programs still behave badly3. The real meaning of "...
2026-02-09
06 min
Abstract Synthesis
Relational Decomposition for Program Synthesis - Céline Hocquette
The way a problem is represented can determine whether it is solvable at all.Céline Hocquette, AI researcher at Ndea and former postdoctoral researcher at the University of Oxford, discusses her paper “Relational Decomposition for Program Synthesis”, which introduces a representation-driven approach to inductive program synthesis based on decomposing examples into relational facts.The paper emerged from Hocquette’s long-standing engagement with inductive logic programming (ILP), beginning with her doctoral work at Imperial College London under Stephen Muggleton and continuing through her time in Andrew Cropper’s group in Oxford...
2026-02-02
47 min
Abstract Synthesis
Symbolic World Models - Top Piriyakulkij
Wasu "Top" Piriyakulkij, PhD student at Cornell University advised by Kevin Ellis, discusses his paper "PoE-World: Compositional World Modeling with Products of Programmatic Experts." The episode explores how symbolic, programmatic world models can achieve strong generalization and sample efficiency by composing many small causal programs instead of learning a single monolithic model.The conversation traces how PoE-World emerged from earlier work on active concept learning and hypothesis testing, and how object-centric Atari environments became a natural testbed for scaling symbolic world models beyond grid worlds. Piriyakulkij reflects on design failures, surprising successes, and the moment the learned...
2026-01-26
57 min
The Dart Board with Daniel Dart
Mike Knoop | Zapier, Arc Prize, Ndea AI Lab — On why scaling LLMs won’t reach AGI, the future of program synthesis, and maximizing the rate of innovation
Meet Mike Knoop — co-founder of Zapier, co-founder of Arc Prize, and co-founder of the NDEA AI Lab. In this wide-ranging conversation, Mike shares his journey from building one of the most capital-efficient SaaS companies ever to taking big swings at the frontier of artificial intelligence.We dive into why scaling language models alone won’t get us to AGI, how benchmarks like ARC expose the limits of today’s systems, and why program synthesis may be the missing piece. We close with what it means to build technology that truly expands human potential, innovation, and adapta...
2026-01-21
44 min
Abstract Synthesis
Vision-Language Programs - Antonia Wüst
Antonia Wüst, PhD student at TU Darmstadt, discusses her paper "Synthesizing Visual Concepts as Vision-Language Programs," which introduces a neuro-symbolic approach to visual concept induction by combining vision-language models with program synthesis.The work grew out of Wüst’s early PhD research on visual concept learning with symbolic programs, initially in synthetic domains, and her dissatisfaction with reliance on pre-trained object detectors. As vision-language models matured, the project evolved into a broader attempt to treat these models as perceptual tools embedded within a symbolic reasoning system.In This...
2026-01-19
54 min
Abstract Synthesis
Inductive Logic Programming - Andrew Cropper
Andrew Cropper, logic luminary and creator of the popular Popper, discusses the paper "Inductive Logic Programming at 30: A New Introduction."This episode examines how inductive logic programming (ILP) learns symbolic rules from examples and background knowledge, and what it takes to build ILP systems that scale. As machine learning has shifted toward opaque, data-hungry models, ILP offers a path to interpretable, constrained programs learned from data. The paper distills 30 years of ideas (learning settings, bias, search, recursion, predicate invention, and system design) into a modern entry point for symbolic generalization.Cropper reflects on how the paper emerged alongside his...
2026-01-12
1h 04
Abstract Synthesis
Symbolic Linear Temporal Logic over Finite Traces Synthesis - Moshe Vardi
Moshe Vardi, Professor at Rice University and one of the most influential figures in logic, verification, and theoretical computer science, discusses his paper “Symbolic LTLf Synthesis”.This conversation explores how Linear Temporal Logic over finite traces (LTLf) provides a more practical and scalable foundation for program and controller synthesis, especially compared to classical approaches based on infinite executions. The discussion traces the deep theoretical roots of synthesis in logic, automata, and games, while connecting them to modern challenges in AI, planning, and autonomy.Moshe shares the origin story of the...
2026-01-05
1h 16
Abstract Synthesis
Live @ NeurIPS 2025
This is a special episode of the Abstract Synthesis podcast featuring a series of live interviews from NeurIPS 2025 in sunny San Diego, California.Rather than centering on a single paper, this episode captures a snapshot of the current research landscape at the Neural Information Processing Systems annual conference, highlighting how program synthesis and symbolic reasoning are increasingly intersecting with vision, reinforcement learning, world models, and scientific discovery. The conversations collectively illustrate why these ideas are resurfacing as key tools for efficiency, interpretability, and generalization.In This Episode -• Visual concept induction using program synthesis combined with vision-language models• Program synt...
2025-12-29
39 min
Abstract Synthesis
Program Synthesis and Non-Monotonic Reasoning - Kedar Namjoshi
Leading formal methods researcher Kedar Namjoshi (Distinguished Member of Technical Staff, Nokia Bell Labs) discusses his extended abstract “Program Synthesis And Non-monotonic Reasoning”.This conversation explores why standard logical specifications, while well-suited for verification, can lead synthesis procedures to produce programs with unnecessary or undesirable actions, and how introducing minimality and preferences fundamentally changes the reasoning model required for synthesis.Kedar shares the research motivations behind the work, tracing its roots to non-monotonic logic and his experience synthesizing real-world control programs, and reflects on how practical scenarios like IoT device coordination expose deep gaps between formal specifications and human expe...
2025-12-22
43 min
Abstract Synthesis
Grammar Filtering For Syntax-Guided Synthesis - Mark Santolucito
Leading program synthesis researcher Mark Santolucito (Assistant Professor, Barnard College, Columbia University) discusses his paper "Grammar Filtering for Syntax-Guided Synthesis".This conversation explores how machine learning can be used to shrink the search space of syntax-guided synthesis (SyGuS) problems, dramatically speeding up synthesis without sacrificing the strong correctness guarantees of formal methods.Mark shares the unexpected origin story of the paper, which began at a hackathon in Bermuda, explains the core ideas behind grammar filtering, and reflects on the broader role of neurosymbolic approaches in modern program synthesis.
2025-12-16
26 min
Abstract Synthesis
Introducing Abstract Synthesis
Welcome to Abstract Synthesis - a podcast where we share the stories behind interesting academic papers in the world of program synthesis.Brought to you by AGI research lab Ndea.Subscribe wherever you get your podcasts to stay tuned for in-depth, technical interviews with leaders in the space of symbolic AI. https://ndea.com
2025-12-15
00 min
FluentFiction - Irish
A Christmas Awakening: Eoin's Journey to Self-Care
Fluent Fiction - Irish: A Christmas Awakening: Eoin's Journey to Self-Care Find the full episode transcript, vocabulary words, and more:fluentfiction.com/ga/episode/2025-12-12-08-38-20-ga Story Transcript:Ga: Bhí an sioc ag glioscarnach ar chrannán an dúlra sa Ghairdín Náisiúnta.En: The frost was glistening on the natural grove in the Ghairdín Náisiúnta.Ga: Bhí an Nollaig anseo.En: Christmas was here.Ga: Bhí atmaisféar draíochta le brath ar fud an áit agus bhí so...
2025-12-12
14 min
Nuacht Mhall
1 Samhain 2025 (An Clár)
Nuacht Mhall. Príomhscéalta na seachtaine, léite go mall.*Inniu an chéad lá de mhí na Samhna. Is mise Niall Ó Cuileagáin.Tá Spéirling Melissa tar éis scrios ollmhór a dhéanamh ar oileáin Mhuir Chairib an tseachtain seo, go háirithe in iardheisceart Iamáice. Bhí luas beagnach 300 ciliméadar san uair faoin ngála gaoithe nuair a tháinig sí i dtír agus í ina catagóir 5 ar dtús mar spéirling. Rinneadh go leor damáiste sa cheantar St Elizabeth agus anois tá cuid mhór den cheantar báite...
2025-11-01
07 min
paul sams modern soul sessions
Podcast 12,another 3 hours of modern soul magic from the one and only paul sams
here we are again like the preverbial bad penny another three hours of bangers for you to enjoy dont forget to click on the like button my furry friends more next week Podcast 12, 3 hours of modern soul magic from the one and only paul sams 1/whitney houston I want to dance with somebody hylnur solvi remix 2/teddy douglas ft pauline taylor don’t turn your back on me shakas club mix 3/atlantic starr love crazy alex di cio drum mix 4/chris bangs and mick talbot kjee 5/david morales life is a song philly mix
2025-10-05
2h 59
mbanerjeepalmer+listennotes 's Listen Later
New top score on ARC-AGI-2-pub (29.4%) - Jeremy Berman
Podcast: Machine Learning Street Talk (MLST) (LS 46 · TOP 1% what is this?)Episode: New top score on ARC-AGI-2-pub (29.4%) - Jeremy BermanPub date: 2025-09-27Get Podcast Transcript →powered by Listen411 - fast audio-to-text and summarizationWe need AI systems to synthesise new knowledge, not just compress the data they see. Jeremy Berman, is a research scientist at Reflection AI and recent winner of the ARC-AGI v2 public leaderboard.**SPONSOR MESSAGES**—Take the Prolific human data survey - https://www.prolific.com/humandatasurvey?utm_source=mlst and be the first to se...
2025-09-29
1h 08
Machine Learning Street Talk (MLST)
New top score on ARC-AGI-2-pub (29.4%) - Jeremy Berman
We need AI systems to synthesise new knowledge, not just compress the data they see. Jeremy Berman, is a research scientist at Reflection AI and recent winner of the ARC-AGI v2 public leaderboard.**SPONSOR MESSAGES**—Take the Prolific human data survey - https://www.prolific.com/humandatasurvey?utm_source=mlst and be the first to see the results and benchmark their practices against the wider community!—cyber•Fund https://cyber.fund/?utm_source=mlst is a founder-led investment firm accelerating the cybernetic economyOct SF conference - https://dagihouse.com/?utm_source=mlst - Joscha Bach keynoting(!) + OAI, Anthropic, NVDA,++Hiring...
2025-09-27
1h 08
Le vecchie storie di nonno Fulcio
La fontanéta de le montagne del sol
La fontanéta de le montagne del sol la conta ‘na bela aventura tocada ai tosatei che i ‘ndea a cior su fragole (o iàsene e fonghi - no me pense pi -) entro par le val, in fondo al Mis, ‘nde che l’è le montagne del sol. Salta fora senpre ‘na fata bona che la se ció a cor ‘sti pupi desgraziadi e la ghe asa qualcossa de bel che ghe fa ben a tuta la iente.
2025-07-28
28 min
Y Combinator Startup Podcast
François Chollet: The ARC Prize & How We Get to AGI
François Chollet on June 16, 2025 at AI Startup School in San Francisco.François Chollet is a leading voice in AI. He's the creator of the Keras library, author of Deep Learning with Python, and the founder of the ARC Prize, a global competition aimed at measuring true general intelligence.He's spent years thinking deeply about what intelligence actually is—and why scaling up today’s AI models isn’t enough to reach it.In this talk, he walks through the limits of pretraining and memorized skills, and lays out a path toward true gener...
2025-07-03
34 min
Village Global Podcast
Vibe Coding and The Rise of AI Agents with Amjad Masad and Yohei Nakajima
Amjad Masad (@amasad), founder and CEO of Replit, and Yohei Nakajima (@yoheinakajima), Managing Partner at Untapped Capital, joined Village Global partner Ben Casnocha for a live masterclass with Village Global founders.Takeaways:AI agents are rapidly evolving, with coding and deep research agents showing the most traction today. But general-purpose assistants are still brittle — trip-planning and high-context tasks remain hard.Replit Agent shows how quickly full-stack applications can be built today, sometimes in under an hour — even by non-technical users. What matters most isn’t a CS degree, it’s traits like curiosity, grit, an...
2025-06-20
58 min
TBPN
Meta Taps Nat Friedman & Daniel Gross for AI Push, Starship Rocket Explodes | Mike Knoop, David Cahn, Walden Yan, Eoghan McCabe, Jeff Weinstein, Garrett Lord, Tanay Tandon
(04:10) - Meta Eyes Nat Friedman & Daniel Gross for AI Push (37:47) - Lakers Sold to Mark Walter (43:39) - Surge Hits $1B+ in Capital Without Outside Revenue (56:20) - Mike Knoop, co-founder of Zapier and CEO of Ndea, discusses the evolving landscape of AI reasoning models, highlighting the trade-offs between accuracy and efficiency among leading systems like OpenAI's o3 and DeepSeek's R1. He emphasizes the importance of considering both cost and performance when evaluating AI models, noting that no single model currently dominates across all metrics. Knoop also underscores the need for innovative approaches, such as program synthesis, to advance toward...
2025-06-19
3h 09
paul sams modern soul sessions
breakfast with samie on jfsr thursday 8,5,25
yesterdays show up early for once ready for those that like to listen saturdays while doing the chores as it ever was lol back live wednesday see ya there Breakfast with samsie on jfsr thursday 8,5,25 1/dj kawasaki ft caroline harding it makes you feel like dancing 2/dj fudge ftsarah summer never surrender 3/sartorial /disco biscuit 4/the jivers do what 5/shuya okino still in love 6/sybil let your self go directors cut 7/rose royce car wash 8/fonda rae over like a fat rat jazz and groove classic mix 9/shuya okino shine
2025-05-09
2h 00
paul sams modern soul sessions
breakfast with samsie on jfsr wednesday 7,5,25
todays show quick as you like for the catchup crew to enjoy and those that want another earfull can help themselves yay see you all live again in the morning x Breakfast with samsie on jfsr wednesday 7,5,25 1/rene and angela secret rendevous reflex revision 2/kelly rowland and david guetta when love takes over 3/mary j blige family affair david guetta remix 4/the reflex weekend ext 5/save the robots halfway 6/bnh ft ndea davenport sometime 7/bhn ft siedah garrett sometimes 8/the commitments ft niamh kavanagh destination anywhere 9/ben westbeach crackazat dames...
2025-05-07
2h 00
Zebras to Apples
Supply Chain Dynamics and Resilience with Dr. Rajbir Bhatti
Host Bryndis Whitson welcomes Dr. Rajbir Bhatti, Associate Professor of Supply Chain Logistics at Mount Royal University, to the show to talk about his career journey and what led him to Mount Royal. Having started with a background in engineering and data analytics, Dr. Bhatt’s PhD explored fuzzy logic in supplier relationship management. He explains this to Bryndis, and shares the academic and applied work that has defined his career, including contributions to logistics education and infrastructure planning in northern Canada. The importance of supply chain resilience is emphasized by Rajbir, especially considering rece...
2025-05-05
1h 03
The MAD Podcast with Matt Turck
Chasing Real AGI: Inside ARC Prize 2025 with Chollet & Knoop
In this fascinating episode, we dive deep into the race towards true AI intelligence, AGI benchmarks, test-time adaptation, and program synthesis with star AI researcher (and philosopher) Francois Chollet, creator of Keras and the ARC AGI benchmark, and Mike Knoop, co-founder of Zapier and now co-founder with Francois of both the ARC Prize and the research lab Ndea. With the launch of ARC Prize 2025 and ARC-AGI 2, they explain why existing LLMs fall short on true intelligence tests, how new models like O3 mark a step change in capabilities, and what it will really take to reach AGI.
2025-04-03
1h 00
Gradient Dissent: Conversations on AI
R1, OpenAI’s o3, and the ARC-AGI Benchmark: Insights from Mike Knoop
In this episode of Gradient Dissent, host Lukas Biewald sits down with Mike Knoop, Co-founder and CEO of Ndea, a cutting-edge AI research lab. Mike shares his journey from building Zapier into a major automation platform to diving into the frontiers of AI research. They discuss DeepSeek’s R1, OpenAI’s O-series models, and the ARC Prize, a competition aimed at advancing AI’s reasoning capabilities. Mike explains how program synthesis and deep learning must merge to create true AGI, and why he believes AI reliability is the biggest hurdle for automation adoption.This conversation covers AGI timeli...
2025-02-04
1h 12
Folha Artificial Podcast
🖥️ OpenAI lança Operator, um agente inteligente que opera seu computador
Bom dia!Na edição de hoje, destacamos o lançamento do Operator, o novo sistema da OpenAI que utiliza agentes para realizar tarefas no navegador de forma independente. Essa inovação está sendo considerada um marco na automação digital e promete aumentar a eficiência em tarefas cotidianas.Na Folha de hoje:* 🖥️ OpenAI lança Operator, um agente inteligente que opera seu computador* 🌍 Deep Seek R1 impressiona a indústria com modelo open source de baixo custo* ⭐ EUA investem US$ 500 bilhões no ambicioso Projeto Stargate* 🗓️ Tarefas Agendad...
2025-01-28
29 min
Подкаст на Вайбе
CES 2025, новики от Nvidia, ChatGPT Tasks, впечатления от o1 Pro и новые модели / AIAPodcast #102
👉 Ответь на 3–4 вопроса и посмотри какие курсы по ИИ тебе могут подойти: https://form.typeform.com/to/pqvILf79 👉 Наш чатик в ТГ: https://t.me/aiapodcast Сегодня обсуждаем запуск ChatGPT Tasks для автоматизации ежедневных задач, новое семейство видеокарт NVIDIA с архитектурой Blackwell, противоречивые планы OpenAI по AGI от Сэма Альтмана, скандал с Meta из-за использования пиратских книг для обучения моделей, прорыв в образовании с помощью ИИ в Нигерии, новое предложение по регулированию экспорта AI-чипов от администрации Байдена, и множество новых моделей и инструментов - включая Phi-4 от Microsoft, Codestral от Mistral, InternLM3, Mnimax-Text-01, Sonus и другие. НАВИГАЦИЯ 0:00 Разгон про о1 Pro 9:47 Начало 13:50 Большие рыбы: CES 2025 1:20:38 Что ещё: модели и очередное ИИ-устройство 1:52:27 Закон и порядок: образование, Meta и ИИ-расслоение Байдена 2:10:00 Наука и техника: роботы 2:13:10 Сервисы и ссылки 2:16:08 Этика: про образование и демографический скачёк ГДЕ НАС СМОТРЕТЬ И СЛУШАТЬ 🔸 YouTube: https://youtube.com/@aiapod 🔸 Apple Podcasts: https://bit.ly/aia-apple 🔸 Spotify: https://bit.ly/aia-spotify 🔸 Скачать mp3: https://aia.simplecast.com/episodes/102 ССЫЛКИ ИЗ ВЫПУСКА 🔹 Витин Linkedin: https://www.linkedin.com/in/viktar-shalenchanka 🔹 Витя в Instagram: https://www.instagram.com/digitalion 🔹 ИИ-сообщество для программистов от Лёши: https://t.me/evocoders 🔹 Наш чат в ТГ: https://t.me/aiapodcast 🔹 Каталог ИИ-сервисов: https://awclub.github.io/catalog 🔹 Nvidia G-Assist: https://www.nvidia.com/en-us/geforce/news/g-assist-ai-companion-for-rtx-ai-pcs/ 🔹 Project Digits: https://www.nvidia.com/en-us/project-digits/ 🔹 Nvidia Cosmos: https://www.nvidia.com/en-us/ai/cosmos/ 🔹 Samsung Galaxy Book5 AI: https://news.samsung.com/global/samsung-diversifies-ai-pc-lineup-with-new-galaxy-book5-pro-and-galaxy-book5-360
2025-01-19
2h 43
Künstlich Intelligent - KI News Podcast
ChatGPT Erinnerungsfunktion | 120 Mio € für deutsches Roboter Startup Neura Robotics | Devin Update | Sony-Patent sagt Spieleingaben voraus | Stability AI 3D Modelle | François Chollet gründet Ndea
In der heutigen Folge von Künstlich Intelligent gibt es wieder spannende Neuigkeiten aus der Welt der KI: OpenAI führt eine Erinnerungsfunktion für ChatGPT ein, die Nutzern hilft, Informationen dauerhaft im Kontext zu behalten. Flux stellt euch eine Methode zum Finetunen bereit, sodass ihr zukünftig Bilder im Stile eurer Brand erstellen könnt. Das deutsche Roboter-Startup Neura Robotics sichert sich beeindruckende 120 Millionen Euro für seine nächste Wachstumsphase. Auch bei Sony gibt es spannende Entwicklungen: Ein neues Patent ermöglicht es, Spieleingaben vorherzusagen und das...
2025-01-18
56 min
AI for Business
AI Reliance: Outsourcing Our Thoughts, Revolutionary AI Labs, and Virtual Fashion Try-Ons!
In Today's AI for Business News:Are we becoming too reliant on AI, and is it affecting our critical thinking?Ndea with a fresh approach to achieving Artificial General Intelligence.Hugging Face’s new Leffa feature, allowing you to try on clothes from the comfort of your home.Google’s partnership with The Associated Press
2025-01-16
02 min
(A)bsolutely (I)ncredible Podcast
AI Researcher François Chollet Founds A New AI Lab Focused On AGI
François Chollet, an influential AI researcher, is launching a new startup that aims to build frontier AI systems with novel designs. The startup, Ndea, will consist of an AI research and science lab. It’s looking to “develop and operationalize” AGI. AGI, which stands for “artificial general intelligence,” typically refers to AI that can perform any task a human can. It’s a goalpost for many AI companies, including OpenAI.“We’re betting on a different path to build AI capable of true invention, adaptation, and innovation,” Chollet wrote in a series of posts on X. “We believe we have a...
2025-01-16
01 min
AI Daily News Podcast
AI Daily News: Thursday January 16, 2025 - Zuck's YouTube Defense & China Companies are Pissed at US
Welcome to AI News! Brought to you by ReallyEasyAI - https://www.youtube.com/@reallyeasyai Links: https://techcrunch.com/2025/01/15/in-ai-copyright-case-zuckerberg-turns-to-youtube-for-his-defense/https://techxplore.com/news/2025-01-ai-tool-fake-news-accuracy.htmlhttps://www.nbcnews.com/news/world/ai-brad-pitt-woman-romance-scam-france-tf1-rcna187745https://arxiv.org/pdf/2501.00663https://www.youtube.com/@AIPapersPodcastDailyhttps://653702-8a.myshopify.com/https://blog.google/outreach-initiatives/google-org/google-org-generative-ai-accelerator-2025/https://impactchallenge.withgoogle.com/genaiaccelerator/https://www.theverge.com/2025/1/15/24343794/google-workspace-ai-features-freehttps://www.usnews.com/news/business/articles/2025-01-15/google-signs-deal-with-ap-to-deliver-up-to-date-news-through-its-gemini-ai-chatbothttps://archive.is/tp4DOhttps://www.whitehouse.gov/briefing-room/presidential-actions/2025/01/14/executive-order-on-advancing-united-states-leadership-in-artificial-intelligence-infrastructure/https://ai.gov/actions/https://ai.gov/apply/#professionalshttps://www.usnews.com/news/technology/articles/2025-01-15...
2025-01-16
46 min
AI-Gen Daily: AI News by AI
AI News: $28M AI Hiring Revolution & Surgical AI Breakthrough | AI-Gen Daily
Breaking down today's biggest AI developments with your host, AI Boyce! Today's AI News Highlights: • Maki's $28.6M funding revolutionizing recruitment • UK graduate schemes facing 140 applications per job • Surgical Data Science Collective's groundbreaking AI implementation • François Chollet's new AGI venture - Ndea In this episode, we explore how AI is transforming recruitment with less bias than humans, revolutionizing surgical safety, and pushing the boundaries of artificial general intelligence. From tackling hiring challenges to improving global healthcare access, discover how AI is reshaping...
2025-01-16
02 min
AI CODZIENNIE - czyli co słychać w sztucznej inteligencji
🤖 Nowa aplikacja Grok, 🛠️ Robotyka OpenAI, 💡 Ndea i wyścig o AGI
W dzisiejszym odcinku AI Codziennie omawiamy:🤖 Nowa aplikacja beta Grok od xAI: Pierwsza niezależna aplikacja na iOS, z funkcjami takimi jak generowanie obrazów i podsumowywanie tekstów.🛠️ Robotyka OpenAI: Powrót do robotyki i plany budowy milionów wielofunkcyjnych robotów.💡 Ndea: François Chollet wkracza do wyścigu o AGI z nowym podejściem łączącym deep learning z programową syntezą.xAI wprowadza aplikację beta dla GrokNowe plany OpenAI dotyczące robotykiFrançois Chollet zakłada laboratorium AI NdeaxAI wprowadza aplikację beta dla Grokhttps://x.c...
2025-01-15
05 min
SCAN Podcast
#4 Nitrosaminas: Como categorizar a potência carcinogência? | ProtonAction
Você já ouviu falar das N-nitrosaminas? Pois bem, saiba que nos últimos anos, estas impurezas se tornaram um grande desafio para a Indústria Farmacêutica. Conhecidas pelo potencial carcinogênico, impactam na segurança de muitos medicamentos. 😟 E se a situação já era complicada com as nitrosaminas clássicas, como NDMA e NDEA, com as nitrosaminas complexas (NDSRI, do inglês nitrosamine drug substance-related impurities), ela se tornou ainda mais desafiadora. A falta de dados confiáveis para estabelecer...
2024-10-20
12 min
The Imagination
S4E93 | Grey - GATE, Mind Files, & the Occult Foundations of the Industrialized Brainwashing Machine
Send me a DM here (it doesn't let me respond), OR email me: imagineabetterworld2020@gmail.comI know you will all be just as excited as I am to have back on the show one of our most requested and beloved guests: Top tier MONARCH operator and whistleblower, Founder of ‘Organize Safety’, podcast host of ‘The Grey Area’, anti-child abuse and survivor advocate, former GATE kid, all around badass warrior, and the absolute love of my life: Grey!A little bit about Grey if you’re new here or missed his first episode where he shared his...
2024-07-01
4h 50
The Imagination
S4E86 | #GATEgate - Gifted & Talented Education (GATE) & Talented & Gifted (TAG) Program Conspiracy
Send me a DM here (it doesn't let me respond), OR email me: imagineabetterworld2020@gmail.comThis is a fun (and impromptu!) episode I did to outline a thread I've been constructing on Twitter that went viral on GATE (Gifted and Talented Education), TAG (Talented and Gifted), and related programs and the different conspiracies surrounding these government programs. Inspired by my incredible partner, @greyareaoperator - who did an absolutely mind-bending episode on GATE and it's relationships to the NDEA and MK ULTRA, I took to Twitter / X and started asking questions. And the result was b...
2024-06-07
1h 31
SONGS & REMIXES
The FunkBro Show RadioactiveFM 158: Jazzmatazz V.1
Welcome, welcome, welcome to The FunkBro Show on RadioActiveFM, Sifnos, Greece! Listen live every Friday, 4PM, EST! http://RadioActiveFM.gr/ The FunkBro Show, brought to you by Retro Roland Riso and Brickhouse, is a place where we can celebrate all things funky! Everyone, have a funky day, and until next time.... Got some funk, bro? Tracklist: Guru f. Ndea Davenport-Trust Me Guru f. Bilal-Certified Brand New Heavies-Have A Good Time Funky Destination-You've Forgot Your Pieces James Taylor Quartet-Wide Angle Groove Collective-Buddha Head Cooly's Hot Box-Touch My Body Soho-Hot Music Dimitri From Paris-Get It Up For Love Incognito-Nights Over Egypt John...
2024-04-28
00 min
They Create Worlds
The Sumerian Game
TCW Podcast Episode 196 - The Sumerian Game The Sumerian Game is one of the first uses of video games to help enhance education. Developed using some funds from the National Defense Education Act, the Sumerian game used education techniques where facts and data could be presented not by a teacher, but by a computer. The game itself is notable because it was designed by Mabel Addis, one of the first women to design a video game. Though the game has been lost to time its influence is felt to this day. The first part was t...
2023-10-15
1h 12
The Imagination
S4E47 | “‘Grey’ - Gifted and Talented Education (GATE) Programs, the NDEA & Connections to MK ULTRA”
Send me a DM here (it doesn't let me respond), OR email me: imagineabetterworld2020@gmail.comI know you will all be just as excited as I am to have back on the show for a second time: Top tier MONARCH operator and whistleblower, military veteran, Founder of ‘Organize Safety’, podcast host and content creator, anti-child abuse advocate, someone who has had a massive and positive impact on my own life and on this project, and the first male mind slave survivor (now of many!) to step up to be featured on my podcast, Grey!Grey...
2023-09-11
2h 42
Crowned N’ Confidence
Hey Girl, Let’s Talk
After a 4 month hiatus, your girl is back! This is a very chill episode to catch up with me, NDea C to give y’all a life update and what y’all can expect from me coming up. Be sure yo follow us on Instagram @crownednconfidence --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2022-09-05
09 min
paul sams modern soul sessions
paul sams modern soul sessions on cruise fm 30 .4 .22
a touch late today but here it is your chance to find out what all the fuss was about todays show on cruise fm the moden soul sessions with samsy on ya wireless dont miss it x more next week 1/unlimited touch ihear music in the street louie vegas touch mix 2/Jackson sisters I believe in miracles djs remix 3/young pulse nalia nova free disco tribute mix 4/teddy douglas till my baby comes home 5/david morales life is a song philly mix 6/timo jahns why cant we live together 7/sebastion yatra tacones...
2022-04-30
3h 00
Murder, Mystery and Mayhem Laced with Morality
Black History Minute- Celebrates Ntozake Shange- playwright, poet, performer, author
Shange was born Paulette L. Williams on October 18, 1948 in Trenton, New Jersey to an Air Force surgeon and an educator/psychiatric social worker. She graduated cum laude with her BS degree in American studies from Barnard College in New York City. In 1973 she changed her name after a failed marriage and suicide attempts. Her new name is from the Xhosa language, Ntozake, meaning “she who comes with her own things,” and Shange, meaning “she who walks among lions.” She then graduated from the University of Southern California in 1973. After joining a dance company she created the Choreo poem: “For colored girls who...
2022-02-23
04 min
Crowned N’ Confidence
Being Intentional In 2022
Being intentional means that you have a clear focus and purpose. In this episode host, NDea C explains why you need to be intentional. If you find yourself struggling with this topic than this episode is for, come and join in on the conversation. --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2022-01-24
10 min
Crowned N’ Confidence
One-sided Friendships
In this episode host NDea talks about how to deal with one sided friendships. A long awaited episode. Remember to subscribe to the Crowned N’ Confidence Podcast to catch our weekly (Monday) episodes. Leave us a review and share with a friend if you enjoyed it . Keep up with us on social media; Instagram @crownednconfidence and follow the host @ndeachynese --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-11-15
20 min
Crowned N’ Confidence
Relationship Series: Toxic Family
This is the second episode to our relationship series. In this episode host NDEA talks about toxic family, gives you the signs and the steps you should take when dealing with them. Remember to subscribe to the Crowned N’ Confidence Podcast to catch our weekly (Monday) episodes. Leave us a review and share with a friend if you enjoyed it . Keep up with us on social media; Instagram @crownednconfidence and follow the host @ndeachynese --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-11-08
15 min
The Way of Jesus by Preston Thomas
Episode 10 – About the Author
This episode provides a brief introduction to Preston Thomas, the author of The Way of Jesus. -- Podcast Transcript Preston Thomas is an author, educator, and teacher. He holds BA and MA degrees in Philosophy from the University of Virginia. As an undergraduate Preston played varsity tennis and he was an NDEA scholar in graduate The post Episode 10 – About the Author appeared first on The Way of Jesus by Preston Thomas.
2021-10-14
02 min
Crowned N’ Confidence
Embrace your journey
Host NDea C talks about the importance of embracing your lifes journey and not trying to mimic anybody's else's lifestyle. You will be left with tips to help you embrace and enjoy this journey along the way. Follow NDea C on instagram @ndeachynese and @crownednconfidence for the official Crowned N’ Confidence Podcast. --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-10-12
18 min
Crowned N’ Confidence
Show up-Hold yourself accountable!
In this episode host NDea C. discusses the importance for holding yourself accountable and showing up for you! You deserve that much, to show up for you. Stay connected with us on social media @crownednconfidence and for more from your host @ndeachynese --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-10-04
14 min
Crowned N’ Confidence
To Procrastinate or To Not
Join hostess NDea C as she discusses how not to procrastinate and leaves you with some helpful tips. Be sure to follow us on Instagram @crownednconfidence. --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-09-13
16 min
Crowned N’ Confidence
Who’s your crowd?
Join Hostess NDea.C as she discusses who you define as your friend and if you may need to do some spring cleaning, to figure out if these individuals still serve purpose in your life. Follow host on Instagram @ndeachynese or the official CNC page @crownednconfidence --- Support this podcast: https://podcasters.spotify.com/pod/show/crownednconfidence/support
2021-08-30
18 min
The EO Business Podcast
Ep 73 New Sydney President(a) Kim Liddell talks EO, trucks and construction
Have you heard the term non-destructive excavations? Well me neither before this interview but Kim's business NDEA is a leading supplier of this service to Tier 1 construction companies all over NSW. What's super impressive about Kim is that she's built up a sizeable business filled with lots of plant and equipment single handedly.Kim is the Sydney EO president for FY22 and clearly she loves getting involved with bsuiness and the community as she's also Vice-President of her industry body, the Civil Contractors Federation.More Infowww.ndea.com.au --------------------
2021-08-22
21 min
From Boomers to Millennials: A Modern US History Podcast
Episode 12 - 1957: The Blessings of the Cold War?
After a brief reflection on troubling recent events in the USA, this episode looks back at a seemingly simpler time - Dwight D. Eisenhower's second term as President. By the late 1950s, Cold War pressures led the US government to build major defense & infrastructure projects, to invest heavily in education & scientific research, & to undertake modest steps in the direction of greater racial equality. The Interstate Highway Act of 1956 was a public works program that created jobs & democratized interstate travel, while displacing some unfortunate urban residents. The USSR's launch of the Sputnik satellites in 1957 led the US to invest in s...
2021-01-16
46 min
NEA en TIC
3ra. Emisión de este hermoso proyecto institucional de radio en la escuela. "Aniversario de la ciudad de La Plata"
Hola a toda la comunidad educativa de la NEA, esperamos que estén muy bien. Estoy muy contenta de presentar la tercer emisión de este hermoso proyecto institucional de radio en la escuela. Para este encuentro la tematica es nuestra ciudad y su 138 aniversario, la utopía de la ciudad ideal imaginada por Julio Verne resiste al paso del tiempo. La Plata, heredera de ese diseño, tiene el formato exacto de France-Ville, descripta en la novela de Verne "Los quinientos millones de la Begún" (1879) En NEA abordando esta temática con una fuerte impr...
2020-11-29
20 min
Que Nos Importa
Que Nos Importa - T6E11 - Falso episodio
En este episodio se habló de: Novelas argentinas, El beso de Lali Espósito, Los sorteos en Instagram, Gente crédula, El término “ndea”, El Age of Empires II, Taringa!, El incidente producto de descargar música con Ares, El reto de destapar cañerías con la boca, Todo debería llamarse Covid Edition, La sección de cine de Laureano Vivas: Falso documental o mockumentary.
2020-10-03
2h 06
paul sams modern soul sessions
paul sams modern soul sessions on cruisefm 3 .10.20
well once again my friend here is this weeks podcast for those with a need to enjoy again or share with friends and neighbours got very busy towards the end i do hope it makes you smile for a short while x 1/dj spen and cornell cc carter keep your head up to the sky original mix 2/Michael Jackson pyt reflex revision 3/Michael wycoff looking up to you 4/Otis clay the only way is up 5/Lukas setto do it again 6/brand new heavies beautiful ilija rudman disco club mix 7/ Francesca Thomas fall into...
2020-10-03
3h 00
paul sams modern soul sessions
paul sams modern soul sessions on cruise fm 12,9,20
well here it is already ? i hear you cry o yes no time like the present to pass on this weeks podcast to you and all your friends and family woo hoo make em fookin ave some samsy on there wireless mwhahah lol x 1/ shuya okino still in love 2/shuya okino feat ndea davenport look anhead the man mix 3/incognito where in this thing together 4/terri green and others whats going on rob hardt remix 5/dreamin about you the blackbyrds 6/paul weller broken stones 7/toots and the maytals 54-46 that’s my number
2020-09-12
3h 02
Cloud Jazz Smooth Jazz
Cloud Jazz Nº 1849 (Especial NDea Davenport)
Edición especial que dedicamos a la vocalista N'Dea Davenport, repasando su disco como solista y sus colaboraciones junto a artistas como Dave Sereny, Michael Paulo, The Headhunters, Mondo Grosso, Louie Vega y José Padilla. Evidentemente también suenan varios temas de sus participaciones en discos de la banda británica The Brand New Heavies.
2020-07-10
00 min
The Jeff is Moody Show
Real Chicks Rock! A Conversation NDea Davenport
Real Chicks Rock Presents Real Discussions A Conversation NDea Davenport
2020-07-05
50 min
DJ Pauly's Deep House Lounge
Time To Get Black - A Deephouse Experience. DJ Pauly (16 May 2020)
Time To Get Black - A Deephouse ExperienceWe go deeper and deeper into the abyssthe dark black hole that won’t let go of youputting you in a hypnotic tranceswaying you side to sidetime to get blacktime to dance….LISTING: Paradise (Original LP Version) - Jasper Street Co. Paradise (Original Dubstrumental) - Jasper Street Co. PRAISE TRACK (TIM MIX) – Timmy Regisford Tribal Preacher (DJEV DRUM MIX) - Elliott 'Dj EV...
2020-05-17
3h 01
Buenas Buenas Podcast
Bueno Truchito y Barato - BBP001
Piloto de lo que seria el programa Buenas Buenas Podcast. Franco y Juani se enfrentan ante el desafió de presentar su primer episodio, ¿sera el principio de una aventura? o ¿sera este el ultimo? ndea. IG: buenaspodcast TW: buenaspodcast
2020-03-30
43 min
Celtic Tomes
Tuatha De Danaan
The Religion of the Ancient Celts (1911) Chapter 5: The Tuatha Dé Danann by J. A. MacCulloch In this chapter, J A McCulloch looks at the nature and origin of the Gods of the Tuatha De Danaan, the tribes or folk of the Goddess Danu. Names Used in this Section Tuatha Dé Danann Danu Fir Dea Brian, Iuchar, and Iucharbar fir tri ndea Dôn Cúchulainn Fionn Fomorians and Milesian Dagda Fla...
2019-11-24
59 min
Tokyo Mega Late Show
MLS #61: The N'dea Davenport Episode
Yes yes yes! Super special episode this week with the Grammy nominated, legendary, brilliant and powerful, N'Dea Davenport! N'dea has had a long and illustrious career in the music industry. We talk about a lot of stuff. From the underground creative community in Los Angeles to working with Guru to her success with the Brand New Heavies to her solo career and current creative endeavors here in Japan. N'dea has always found ways to express herself while staying true to her sense of artistic integrity. Balancing the past with the future. Being electric. Living in Japan and starting her newest...
2019-01-25
2h 50
The HealthPod
More Valsartan recalls! Drug approvals, and Cholesterol medications
This episode reviews what has happened in the previous week in healthcare. For more information on the topics discussed please see the links provided. Valsartan recall: https://www.medscape.com/viewarticle/906158 FDA list of recent Mylan lots: https://www.fda.gov/Safety/Recalls/ucm627647.htm?utm_campaign=FDA%20updates%20on%20angiotensin%20II%20receptor%20blocker%20(ARB)%20recalls:%20Mylan%20expands&utm_medium=email&utm_source=Eloqua This Table will go over "NDMA" levels not NDEA as mentioned. NDEA results will be released at a later date: https://www.fda.gov/Drugs/DrugSafety/ucm622717.htm Medications other than statins: https://www.medscape.com...
2018-12-12
20 min
The Cutting Ed Podcast
EP 12 How Parents, Teachers and Community Influence Innovative Education with Nick Archuleta
Nick Archuleta is on leave from the faculty at Century High School in Bismarck where he taught Spanish I and II. He was elected as President of NDEA in June 2013, and is serving as the first-ever President of North Dakota United. Archuleta also served on the NDEA Board of Directors and is former Vice Chairman of the Education Standards and Practices Board having been appointed by former Governor John Hoeven as well as by Governor Jack Dalrymple.Resources:www.ndplaylist.orgwww.ndunited.org/thecuttingedTwitter:@thecuttinged@NDUNick
2018-02-06
19 min
Nordea Corporate Insights
Does flattening US yield curve spell recession risk?
“Don’t panic” is Jan von Gerich’s response to the recent flattening of the US yield curve. Yet an inversion of the yield curve has proceeded each and every US recession since the mid-50s. Hear why we don’t need to worry just yet in this podcast where Anders Svendsen and Jan von Gerich discuss the various scenarios and what “danger signals” to be aware of. Read the full research piece “Yield curve not sending recession signals yet”: http://ndea.mk/2F3EnbZ. Disclaimer: All opinions and estimates in this podcast are, regardless of source, given in good faith, and may onl...
2018-01-05
14 min
Nordea Markets Insights DK
Does flattening US yield curve spell recession risk?
“Don’t panic” is Jan von Gerich’s response to the recent flattening of the US yield curve. Yet an inversion of the yield curve has proceeded each and every US recession since the mid-50s. Hear why we don’t need to worry just yet in this podcast where Anders Svendsen and Jan von Gerich discuss the various scenarios and what “danger signals” to be aware of. Read the full research piece “Yield curve not sending recession signals yet”: http://ndea.mk/2F3EnbZ. Disclaimer: All opinions and estimates in this podcast are, regardless of source, given in good faith, and may onl...
2018-01-05
14 min
Finest Radio Show Underground House Music
FINEST RADIOSHOW #263 (27-09-2014)
Tortured Soul feat. NDea Davenport – I Might do Something Wrong (John-Christian Urich & JKriv Original Mix) [TSTC] Jonny Montana feat. Dawn Williams - Amazing (Masaki Morii Remix) [Cameo] ]Vick Lavender - Portuguese love (Sophisticado V.L.E Demo Dub) [Sophisticado] Nina Provencal - Soul Saviour (DJ Fudge Remix) [Makin Moves] Earl Tu Tu & John Khan feat. EmmaDiva - Lean On Me (Guido P Atmosphere Mix) [HSR] YSE, Frank H. Carter III - Someone Like You (DJ Bene's Do Not Rewind It remix) [Lost My Dog] Blue Boy - Remember Me (Deep Zone mix) [Altra Moda Music] Milty Evans - Feel That Lo...
2014-09-28
1h 00
Call Me Cleve
Episode 11 - Heatwave of House!!
I know I know, it's been a minute so here's 2+ hours of some of the hottest house music out there. This episode we're mixing it up a bit - we're featuring music from KID Recordings "KEEP IT DEEP". I've known the founder Craig Roseberry for 15+ years. He has been in the game for a minute and has always had his finger on the pulse... KID RECORDINGS is an independent label venture from industry veteran Craig Roseberry of New York-based Shifty Entertainment artist management and marketing company. A partnership with singer/songwriter, producer/remixer and DJ, Rich M...
2014-07-26
2h 13
Sonidos de Ébano Podcast
Sonidos de Ébano 4x11 - Novedades + Popurrí Funk/Rap Old School y Tributo a Lyn Collins, Dj E-Z Rock y Guru
Comenzamos con los trabajos recientes de dos de las cantautoras más interesantes del panorama musical europeo con raíz africana: Ntjam Rosie y Ayo. Rescatamos el potente funk de Lyn Collins, degustando su trabajo Think About it (1972). Y nos sumergimos de lleno en la época Old School del Rap, escuchando a algunos de tantos que samplearon a Lyn Collins, como el recientemente fallecido Dj E-Z Rock. Para rematar, terminamos el programa con un SORTEO. Regalamos un discazo de Guru, del que se cumplía este mes de Abril el 4º aniversario de su muerte. Para participar sólo tienes que enviar...
2014-05-07
59 min
Finest Radio Show Underground House Music
FINEST RADIOSHOW #226 (09-11-2013)
Tortured Soul feat. NDea Davenport – I Might do Something Wrong (John-Christian Urich & JKriv Original Mix) [TSTC] Jonny Montana feat. Dawn Williams - Amazing (Masaki Morii Remix) [Cameo] Vick Lavender - Portuguese love (Sophisticado V.L.E Demo Dub) [Sophisticado] Nina Provencal - Soul Saviour (DJ Fudge Remix) [Makin Moves] Earl Tu Tu & John Khan feat. EmmaDiva - Lean On Me (Guido P Atmosphere Mix) [HSR] YSE, Frank H. Carter III - Someone Like You (DJ Bene's Do Not Rewind It remix) [Lost My Dog] Blue Boy - Remember Me (Deep Zone mix) [Altra Moda Music] Milty Evans - Feel That Lo...
2013-11-09
1h 00
SoulSearching Podcast
SoulSearching Episode #658
....sometimes you need a break . . . and then all comes back. welcome to the return of this weekly 2hrs show called soulsearching, produced in the soulsearching studio in frankfurt, in it's 15th year now. merci bien, muchas gracias, arigato, grazie mille, thank you all so much for being patient and all your nice words that you've sent in throughout the last months. much appreciated. now here it is, a bit of catching up but all 'n' all just another spontaneous selection of music that i am into. hope you like it. loads of mixes been coming in as well, now i...
2012-04-25
00 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 12/19
Mutagensensitivität und DNA-Reparaturkapazität als endogene Risikofaktoren für die Entstehung von Kopf-Hals-Tumoren
Neben den anerkannten Risikofaktoren Alkohol und Rauchen gewinnt die individuelle Suszeptibilität, als zusätzlicher Risikofaktor für die Entwicklung von Kopf-Hals-Tumoren zunehmend an Bedeutung. Eine genetische Disposition zur DNA-Instabilität oder präformierte Defizite im Bereiche der DNA-Reparaturmechanismen begünstigen das Auftreten und die Persistenz kritischer Mutationen. Durch diese „endogenen“ Risikofaktoren wird eine Tumorenstehung begünstigt, so dass manche Personen, bei gleicher Expositionsstärke und -dauer gegenüber exogenen kanzerogenen Einflüssen, leichter ein Karzinom entwickeln, als andere. In der vorliegenden Arbeit sollte untersucht werden, ob Unterschiede in der Mutagensensitivität und/oder der DNA-Reparaturkapazität zwischen einer Versuchsgruppe aus Patienten mi...
2011-02-03
00 min
EJ Flavors
Acid Jazz, Volume 8: Stay This Way
Up to the plate... Carleen Anderson, Jamiroquasi, Jhelisa, ATCQ, Sunburst Band, Reel People, Brand New Heavies, Corduroy, The Rebirth, DNote, Brooklyn Funk Essentiasls, Galliano, NDea, Koop.
2009-12-16
1h 19
Andro Podcast
Indigo 5 (2006)
01. Wiron - Beatbox (Andro intro edit) 02. Dave Robertson - 1 Dunk Wonder (The Electric RePress remix) [Twisted Frequency] 03. Stefy - Chelsea (Morgan Page dub mix) [Wind Up] 04. Dani Moreno - In My Glass [Irresistible] 05. Ndea Davenport - One Day My Love (D Ramirez Dub) [Curvve Records] 06. Nils Noa - Stereo Style [Lot 49] 07. Dumb Dan & Rasmus - Ljus (Patirk Bjorkman remix) [Dumb Records] 08. Rhythm Mechanic - Flux (Zimbardo & Zigmund Slezak remix) [Erase Records] 09. The Knife - We Share Our Mothers Health (Trentemoller remix) [Brille] 10. Oliver Nickels - On The Pulse [Mena Music]
2006-09-01
55 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 05/19
Miniorgane humaner nasaler Mukosa als Modell zur Evaluierung genotoxischer Effekte von Umweltstoffen in Zielzellen der Karzinogenese
Die Schleimhaut des nasalen Raums stellt das primäre Kontaktorgan für inhalierte Stoffe dar. Um den Körper vor toxischen Wirkungen zu schützen und den Geruchssinn zu unterstützen, besitzen die Epithelzellen der respiratorischen Anteile erhebliche metabolische Kompetenz. Interindividuelle Unterschiede im Fremdstoffmetabolismus können in Verbindung mit einer beruflichen Exposition gegenüber inhalativen Karzinogenen zur Entstehung von Malignomen des sinonasalen Raums führen. Um gefährliche Stoffe und gefährdete Populationen anhand von in-vitro-Versuchen identifizieren zu können, wurde ein dreidimensionales Kultursystem humaner nasaler Mukosa vorgestellt, das die Verhältnisse in vivo möglichst realistisch abbildet. Dazu wurden Resektate hum...
2006-06-22
00 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 03/19
Entwicklung eines Modells zur Testung der Genotoxizität von Umweltstoffen anhand von Miniorgankulturen humaner nasaler Mukosazellen
Umwelt- und Arbeitsstoffe stellen wichtige Faktoren bei der Kanzerogenese im menschlichen Körper dar. In der vorliegenden Arbeit wurden einige Vertreter von Umweltstoffen ausgewählt und auf ihre kanzerogene Wirkung hin untersucht: N-Nitrosodiethylamin (NDEA) für die Nitrosamine, Natriumdichromat (Na2Cr2O7) für die Chromverbindungen, Mono(2-Ethylhexyl)-Phthalat (MEHP) für die Phthalate und Benzo[a]pyren-Diolepoxid (BPDE) für die polyzyklischen Kohlenwasserstoffe. Als Negativkontrolle diente Dimethylsulfoxid (DMSO) und als Positivkontrolle N-Methyl-N‘-Nitro-N-Nitrosoguanidin (MNNG). Da viele dieser Stoffe über die Atemwege aufgenommen werden, ist die Schleimhaut des oberen Aerodigestivtraktes besonders exponiert. Als Untersuchungsmaterial diente deshalb humane nasale Schleimhaut. Um möglichst...
2004-11-11
00 min
Medizin - Open Access LMU - Teil 12/22
Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay
Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most xenobiotics harm their target in a repetitive or chronic manner. Therefore, we propose a model, which provides repetitive incubations in human upper aerodigestive tract mucosa cultures. Samples of human inferior nasal turbinate mucosa (n = 25) were cultured according to a modified version of a technique originally described by Steinsvag. On day 1 fresh samples and on days 7, 9 and 11 organ cultures were incubated...
2001-01-01
00 min