Shows
Stroke AlertStroke Alert April 2025 On Episode 51 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2025 issue of Stroke: “Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial” and “Association Between Thrombus Composition and Etiology in Patients With Acute Ischemic Stroke Treated by Thrombectomy.” She also interviews Dr. Roland Veltkamp about the PRESTIGE-AF trial, presented in February at the International Stroke Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250414.5790892025-04-171h 07
Stroke AlertStroke Alert March 2025 On Episode 50 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2025 issue of Stroke: “Impact of Subarachnoid Hemorrhage on Human Glymphatic Function: A Time-Evolution Magnetic Resonance Imaging Study” and “Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Trials.” She also interviews Drs. Mayank Goyal and Michael Hill about the ESCAPE-MeVO trial, presented in February at the International Stroke Conference. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250314.8383102025-03-2059 min
Stroke AlertStroke Alert February 2025 On Episode 49 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2025 issue of Stroke: “Safety of Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy: The ALLY Pilot Trial” and “Large-Scale Plasma Proteomics Profiles for Predicting Ischemic Stroke Risk in the General Population.” She also interviews Drs. Tao Wang and Yan Ma about their article “Determining the Optimal Age for Extracranial-Intracranial Bypass Surgery: A Post Hoc Analysis of the CMOSS Randomized Trial.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250212.4113692025-02-2052 min
Stroke AlertStroke Alert January 2025 On Episode 48 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2025 issue of Stroke: “Hypoglycemic Events May Trigger Acute Ischemic Stroke Within 30 Days in Those With Diabetes: A Case-Crossover Study” and “Efficacy and Safety of a Dedicated Device for Cerebral Venous Thrombectomy: A Pilot Randomized Clinical Trial.” She also interviews Drs. Johanna Ospel and Umberto Pensato about their article “Cerebral Infarct Growth: Pathophysiology, Pragmatic Assessment, and Clinical Implications.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20250113.682162025-01-1650 min
Stroke AlertStroke Alert December 2024 On Episode 47 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Ashutosh Jadhav, Professor of Neurology and Neurosurgery at the Barrow Neurological Institute, for the 2024 Ralph Sacco Review of Top Cerebrovascular Research. In honor of the late Dr. Ralph L. Sacco, former Editor-in-Chief of Stroke, who died in January 2023, Drs. Asdaghi and Jadhav review some of the top cerebrovascular science published in any journal or presented at any scientific forum throughout the past year. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241213.4151392024-12-191h 09
Stroke AlertStroke Alert November 2024 On Episode 46 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2024 issue of Stroke: “Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review” and “Oxygen Extraction Fraction Mapping on Admission Magnetic Resonance Imaging May Predict Recovery of Hyperacute Ischemic Brain Lesions After Successful Thrombectomy: A Retrospective Observational Study.” She also interviews Drs. Mitch Wilson and Vasileios-Arsenios Lioutas about their article “Association of Anticoagulant Use With Hemorrhage Location and Etiology in Incident Spontaneous Intracerebral Hemorrhage.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241112.9073882024-11-251h 01
Stroke AlertStroke Alert October 2024 On Episode 45 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2024 issue of Stroke: “Cigarette Smoking and Observed Growth of Unruptured Intracranial Aneurysms: A Systematic Literature Review and Meta-Analysis” and “Clinical and Prognostic Characteristics of Acute BAD–Related Stroke: A Multicenter MRI–Based Prospective Study.” She also interviews Dr. Vignan Yogendrakumar about his article “Emerging Adjuvant Thrombolytic Therapies for Acute Ischemic Stroke Reperfusion.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20241007.1169512024-10-1758 min
Stroke AlertStroke Alert September 2024 On Episode 44 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2024 issue of Stroke: “Stroke Risk After Emergency Department Treat-and-Release Visit for a Fall” and “Higher Risk of Mental Illness in Patients with Diagnosed and Untreated, Unruptured Intracranial Aneurysm: Findings from a Nationwide Cohort Study.” She also interviews Dr. Yutong Chen and Professor Hugh Markus about the article “Improved Dementia Prediction in Cerebral Small Vessel Disease Using Deep Learning–Derived Diffusion Scalar Maps From T1,” published in Stroke. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240913.3687072024-09-191h 01
Stroke AlertStroke Alert August 2024 On Episode 43 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2024 issue of Stroke: “Diagnostic Accuracy of Posterior/Anterior Periventricular WMH Ratio to Differentiate CAA From Hypertensive Arteriopathy” and “Statin Overuse in Cerebral Ischemia Without Indications: Systematic Review and Annual US Burden of Adverse Events.” She also interviews Dr. Gang Li about the article “Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke,” published in The New England Journal of Medicine. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240726.9089612024-08-1557 min
Stroke AlertStroke Alert July 2024 On Episode 42 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2024 issue of Stroke: “Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial” and “Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception.” She also interviews Dr. Manabu Inoue about his article “Expanding the Treatable Imaging Profile in Patients With Large Ischemic Stroke: Subanalysis From a Randomized Clinical Trial.”2024-07-1852 min
Stroke AlertStroke Alert June 2024 On Episode 41 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2024 issue of Stroke: “Global, Regional, and National Burdens of Stroke in Children and Adolescents From 1990 to 2019: A Population-Based Study” and “Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults.” She also interviews Dr. Raul Nogueira about his article “Endovascular Versus Medical Management in Distal Medium Vessel Occlusion Stroke: The DUSK Study” and highlights some of the science presented at the recent European Stroke Organisation Conference.2024-06-201h 08
Stroke AlertStroke Alert May 2024 On Episode 40 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2024 issue of Stroke: “Incidence and Outcomes of Posterior Circulation Involvement in Moyamoya Disease” and “Glymphatic System Impairment Contributes to the Formation of Brain Edema After Ischemic Stroke.” She also interviews Dr. Susanne van Veluw about her American Heart Association Centennial Collection article on “Cerebral Amyloid Angiopathy.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240507.2583072024-05-1645 min
Stroke AlertStroke Alert April 2024 On Episode 39 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2024 issue of Stroke: “Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials” and “Radial Versus Femoral Access for Mechanical Thrombectomy in Stroke Patients: A Non-Inferiority Randomized Clinical Trial.” She also interviews Dr. Shadi Yaghi about his article “Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240401.4808652024-04-1846 min
Stroke AlertStroke Alert March 2024 On Episode 38 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2024 issue of Stroke: “High-Serum Brain-Derived Neurotrophic Factor Levels Are Associated With Decreased Risk of Poststroke Cognitive Impairment” and “Long-Term Risk of Arterial Thrombosis After Intracerebral Hemorrhage: MUCH-Italy.” She also interviews Drs. Santosh Murthy and Wendy Ziai about their article “Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240311.1540392024-03-2148 min
Stroke AlertStroke Alert February 2024 On Episode 37 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2024 issue of Stroke: “Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study” and “Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes.” She also interviews Drs. Brian Hoh and Marc Chimowitz on the Focused Update series of articles in this issue on the topic of intracranial atherosclerosis. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20240209.6454972024-02-1556 min
Stroke AlertStroke Alert January 2024 On Episode 36 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2024 issue of Stroke: “Time Window for Induced Hypertension in Acute Small Vessel Occlusive Stroke With Early Neurological Deterioration” and “Patent Foramen Ovale Management for Secondary Stroke Prevention: State-of-the-Art Appraisal of Current Evidence.” She also interviews Drs. Kelly Flemming and Issam Awad about their articles “Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage. Part I: Event Rates and Clinical Outcome” and “Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage. Part II: Biomarkers and Trial Modeling.” For the episode transcript, visit: https://www.ahajournals...2024-01-241h 02
Stroke AlertStroke Alert December 2023 On Episode 35 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Ashkan Shoamanesh, Associate Professor of Neurology at McMaster University, for the inaugural 2023 Ralph L. Sacco Review of Top Cerebrovascular Research of the Year. In honor of the late Dr. Ralph L. Sacco, former Editor-in-Chief of Stroke, who died in January 2023, Drs. Asdaghi and Shoamanesh review some of the top cerebrovascular science published in any journal or presented at any scientific forum throughout the past year. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20231206.2343642024-01-1052 min
Stroke AlertStroke Alert November 2023 On Episode 34 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2023 issue of Stroke: “Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma” and “Robot-Assisted Transcranial Doppler Versus Transthoracic Echocardiography for Right to Left Shunt Detection.” She also interviews Dr. Thalia Field about her article “Study of Rivaroxaban for Cerebral Venous Thrombosis: A Randomized Controlled Feasibility Trial Comparing Anticoagulation With Rivaroxaban to Standard-of-Care in Symptomatic Cerebral Venous Thrombosis.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20231027.5727522023-11-1657 min
Stroke AlertStroke Alert October 2023 On Episode 33 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2023 issue of Stroke: “Spreading Depolarizations Suppress Hematoma Growth in Hyperacute Intracerebral Hemorrhage in Mice” and “Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage.” She also interviews Dr. Rebecca Gottesman about her article “Cerebral Microbleed Patterns and Cortical Amyloid-β: The ARIC-PET Study.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20231004.4455262023-10-1945 min
Stroke AlertStroke Alert September 2023 On Episode 32 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2023 issue of Stroke: “Prestroke and Poststroke Sulfonylurea Exposure and Functional Outcomes: A Post Hoc Analysis of the SHINE Trial” and “Sleep Duration Is Associated With Subclinical Carotid Plaque Burden.” She also interviews Dr. Alexandros Polymeris and Prof. Philippe Lyrer about their article “Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230829.1233652023-09-2145 min
Stroke AlertStroke Alert August 2023 On Episode 31 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2023 issue of Stroke: “Cancer Prediction With Machine Learning of Thrombi From Thrombectomy in Stroke: Multicenter Development and Validation” and “Differences in Stroke Recurrence Risk Between Atrial Fibrillation Detected on ECG and 14-Day Cardiac Monitoring.” She also interviews Dr. Robert Starke about the article “Outcome Evaluation of Repeat Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230802.7501212023-08-1747 min
Stroke AlertStroke Alert July 2023 On Episode 30 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2023 issue of Stroke: “Temporal Trends and Determinants of Stroke Risk in Patients With Medically Treated Asymptomatic Carotid Stenosis” and “Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombectomy.” She also interviews Drs. Thanh N. Nguyen and Simon Nagel about their article “Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230629.2758442023-07-2048 min
Stroke AlertStroke Alert June 2023On Episode 29 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2023 issue of Stroke: “Prevalence and Procedural Risk of Intracranial Atherosclerotic Stenosis Coexisting With Unruptured Intracranial Aneurysm” and “Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9 Million Adolescents.” She also interviews Dr. Darren B. Orbach about his article "Transuterine Ultrasound-Guided Fetal Embolization of Vein of Galen Malformation, Eliminating Postnatal Pathophysiology." For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230530.622172023-06-151h 05
Stroke AlertStroke Alert May 2023 On Episode 28 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2023 issue of Stroke: “Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study” and “Stroke Prevention and Treatment in People With Type 2 Diabetes: Is There a Role for GLP-1 (Glucagon-Like Peptide-1) Analogues?” She also interviews Drs. Kanishk Kaushik and Marieke J.H. Wermer about their article “Iatrogenic Cerebral Amyloid Angiopathy Post Neurosurgery: Frequency, Clinical Profile, Radiological Features, and Outcome.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230501.274417 2023-05-1848 min
Stroke AlertStroke Alert April 2023 On Episode 27 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2023 issue of Stroke: “Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion” and “Early Stroke and Mortality After Percutaneous Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation.” She also interviews Drs. Wenting Zhang and Jun Chen about their article “Poststroke Intravenous Transplantation of Human Mesenchymal Stem Cells Improves Brain Repair Dynamics and Functional Outcomes in Aged Mice.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230407.8970782023-04-2043 min
Stroke AlertStroke Alert March 2023 On Episode 26 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2023 issue of Stroke: “Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion” and “Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke.” She also interviews Dr. Mitchell Elkind about the life and the legacy of Dr. Ralph L. Sacco, Stroke’s Editor-in-Chief, who died January 17, 2023. For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230308.7767202023-03-1649 min
Stroke AlertStroke Alert February 2023On Episode 25 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2023 issue of Stroke: “Early Antiplatelet Resumption and the Risks of Major Bleeding After Intracerebral Hemorrhage” and “Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion.” She also interviews Dr. Lauren H. Sansing about her article “Role of Inflammatory Processes in Hemorrhagic Stroke.” For the episode transcript, visit: https://www.ahajournals.org/do/10.1161/podcast.20230203.583057.2023-02-1644 min
Stroke AlertStroke Alert January 2023On Episode 24 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: “Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation” and “Subarachnoid Hemorrhage During Pregnancy and Puerperium.” She also interviews Dr. Georgios Tsivgoulis about his article “Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.” Dr. Negar Asdaghi: Let's start with some questions. 1) When during pregnancy is an intracranial aneurysm at the highest risk of rupture? 2) What does the presence of covert brain infarcts mean...2023-01-1944 min
Stroke AlertStroke Alert December 2022On Episode 23 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the December 2022 issue of Stroke: “Direct, Indirect, and Combined Extracranial-to-Intracranial Bypass for Adult Moyamoya Disease” and “Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States.” She also interviews Drs. Koji Tanaka and Andrew Demchuk about article “Significance of Baseline Ischemic Core Volume on Stroke Outcome After EVT in Patients Age ≥75 Years.” Dr. Negar Asdaghi: Let's start with some questions. 1) Is direct bypass better than indirect bypass in preventing the future risk of vascular events in adult patients with...2022-12-1547 min
Stroke AlertStroke Alert November 2022On Episode 22 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2022 issue of Stroke: “Estimating Perfusion Deficits in Acute Stroke Patients Without Perfusion Imaging” and “Five-Year Results of Coronary Artery Bypass Grafting With or Without Carotid Endarterectomy in Patients With Asymptomatic Carotid Artery Stenosis.” She also interviews Dr. George Ntaios about his article “Incidence of Stroke in Randomized Trials of COVID-19 Therapeutics.” Dr. Negar Asdaghi: Let's start with some questions. 1) What is the actual incidence of stroke after COVID-19? 2) In the setting of acute ischemic stroke, can the volume of ischem...2022-11-1744 min
Stroke AlertStroke Alert October 2022On Episode 21 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2022 issue of Stroke: “Oral Contraceptives, Hormone Replacement Therapy, and Stroke Risk” and “Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage.” She also interviews Dr. Shadi Yaghi about his article “Direct Oral Anticoagulants Versus Vitamin K Antagonists in Cerebral Venous Thrombosis.” Dr. Negar Asdaghi: Let's start with some questions. 1) Do hormone replacement therapies or oral contraceptives increase the risk of stroke? And if yes, does the age of the individual or the duration of therapy modify th...2022-10-2041 min
Stroke AlertStroke Alert September 2022On Episode 20 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2022 issue of Stroke: “Transdural Revascularization by Multiple Burrhole After Erythropoietin in Stroke Patients With Cerebral Hypoperfusion” and “Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and Without Sickle Cell Trait.” She also interviews Dr. Timo Uphaus about his article “Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis.” Dr. Negar Asdaghi: Let's start with some questions. 1) Can performing multiple burrholes improve misery perfusion in patients with moyamoya disease? And if yes, how do the results compa...2022-09-1542 min
Stroke AlertStroke Alert August 2022On Episode 19 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2022 issue of Stroke: “Direct to Angiosuite Versus Conventional Imaging in Suspected Large Vessel Occlusion” and “Recurrent Ischemic Stroke and Bleeding in Patients With AF Who Suffered an Acute Stroke While on Treatment With NOACs.” She also interviews Dr. Alexander Nave about “Combined Oral Triglyceride and Glucose Tolerance Test After Acute Ischemic Stroke to Predict Recurrent Vascular Events.” Dr. Negar Asdaghi: Let's start with a few questions. 1) How much time do we actually save if we were to transfer all patients with su...2022-08-1835 min
Stroke AlertStroke Alert July 2022On Episode 18 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2022 issue of Stroke: “Impact of Shunting Practice Patterns During Carotid Endarterectomy for Symptomatic Carotid Stenosis” and “Socioeconomic Inequalities in Reperfusion Therapy for Acute Ischemic Stroke.” She also interviews Dr. Magdy Selim about his article “Effect of Deferoxamine on Trajectory of Recovery After Intracerebral Hemorrhage: A Post Hoc Analysis of the i-DEF Trial.” Dr. Negar Asdaghi: Let's start with some questions. 1) Is deferoxamine mesylate yet another failed agent for treatment of patients with intracerebral hemorrhage, or is deferoxamine getting us closer than ever...2022-07-2137 min
Stroke AlertStroke Alert June 2022On Episode 17 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2022 issue of Stroke: “Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage” and “Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns.” She also interviews Dr. Bruce Campbell on his article “Role of Intravenous Thrombolytics Prior to Endovascular Thrombectomy.” Dr. Negar Asdaghi: Let's start with some questions. 1) Is vitamin D that golden key to recovery from intracerebral hemorrhage? 2) Endovascular therapies seem to have prevailed where thrombolytics have failed. In the era of fast a...2022-06-1633 min
Stroke AlertStroke Alert May 2022On Episode 16 of the Stroke Alert Podcast, Dr. Negar Asdaghi highlights two articles from the May issue of Stroke: “Number of Affected Relatives, Age, Smoking, and Hypertension Prediction Score for Intracranial Aneurysms in Persons With a Family History for Subarachnoid Hemorrhage” and “Endovascular Treatment for Acute Ischemic Stroke With or Without General Anesthesia.” She also interviews Dr. Patrick Lyden on “The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results.” Dr. Negar Asdaghi: Let's start with some questions. 1) How is it that stroke can be cured in rodents but not in humans? 2) Are we wasting time...2022-05-1932 min
Stroke AlertStroke Alert April 2022On Episode 15 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2022 issue of Stroke: “Kawasaki Disease May Increase the Risk of Subsequent Cerebrovascular Disease” and “Effect of Moderate and Severe Persistent Hyperglycemia on Outcomes in Patients With Intracerebral Hemorrhage.” She also interviews Dr. François Gros-Louis about his article “Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function.” Dr. Negar Asdaghi: 1) How would you counsel the parent of a child who has just recovered from Kawasaki disease on their child's future risk of having a stroke? 2) Should we or should we not treat stress hyp...2022-04-2136 min
Stroke AlertStroke Alert March 2022On Episode 14 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2022 issue of Stroke: “Natural Course of Cerebral Cavernous Malformations in Children” and “Direct Oral Anticoagulants Versus Warfarin in Cerebral Venous Thrombosis (ACTION-CVT).” She also interviews Dr. Mohammad Anadani about his article “Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes.” Dr. Negar Asdaghi: 1) Are direct oral anticoagulants a reasonable alternative to warfarin for treatments of patients with cerebral venous thrombosis? 2) What are the predictors of first and recurrent intracerebral hemorrhage in patients with cerebral cavernous malformation? 3) Is there an...2022-03-1735 min
Stroke AlertStroke Alert February 2022On Episode 13 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2022 issue of Stroke: “Cannabis Use and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage” and “Infertility, Miscarriage, Stillbirth, and the Risk of Stroke Among Women: A Systematic Review and Meta-Analysis.” She also interviews Dr. Pierre Amarenco about his article “Intracranial Hemorrhage in the TST Trial.” Dr. Negar Asdaghi: 1) Can marijuana use increase the risk of ischemic stroke in patients with aneurysmal subarachnoid hemorrhage? 2) Is there an association between infertility or miscarriage and development of stroke later in life? 2022-02-1733 min
Stroke AlertStroke Alert January 2022On Episode 12 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2022 issue of Stroke: “Efficacy of Intravenous Mesenchymal Stem Cells for Motor Recovery After Ischemic Stroke: A Neuroimaging Study” and “Cumulative Concussion and Odds of Stroke in Former National Football League Players.” She also interviews Dr. Mike Sharma about his article “Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial.” Dr. Negar Asdaghi: 1) Can repeated concussions increase the risk of stroke in professional athletes? 2) Does stem cell therapy enhance the recovery...2022-01-2033 min
Stroke AlertStroke Alert December 2021On Episode 11 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the December 2021 issue of Stroke: “Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial” and “Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial.” She also interviews Dr. Mark Parsons about his article “Stroke Patients With Faster Core Growth Have Greater Benefit From Endovascular Therapy.” Dr. Negar Asdaghi: 1) Can the presence of a high-grade asymptomatic carotid stenosis result in development of early dementia? 2) Have you ever wondered if a random...2021-12-1642 min
Stroke AlertStroke Alert November 2021On Episode 10 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2021 issue of Stroke: “Biomarkers of Coagulation and Inflammation in COVID-19–Associated Ischemic Stroke” and “Treatment-Associated Stroke in Patients Undergoing Endovascular Therapy in the ARUBA Trial.” She also interviews Dr. S. Claiborne Johnston about “Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack.” Dr. Negar Asdaghi: 1) What is the net ischemic benefit derived from combination of ticagrelor and aspirin treatment in patients with mild ischemic stroke or transient ischemic attack? 2021-11-1828 min
Stroke AlertStroke Alert October 2021On Episode 9 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2021 issue of Stroke: “Endovascular Therapy of Anterior Circulation Tandem Occlusions” and “Automated Perfusion-Diffusion Magnetic Resonance Imaging in Childhood Arterial Ischemic Stroke.” She also interviews Dr. Sepideh Amin-Hanjani about her article “Outcome Following Hemorrhage From Cranial Dural Arteriovenous Fistulae.” Dr. Negar Asdaghi: 1) Should perfusion imaging be incorporated into routine neuroimaging for stroke-like presentation in the pediatric population? 2) Is performing emergent cervical carotid stenting beneficial in patients undergoing endovascular thrombectomy for a tandem occlusion? 3) What are the outcomes...2021-10-2133 min
Stroke AlertStroke Alert September 2021On Episode 8 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2021 issue of Stroke: “Risk of Fractures in Stroke Patients Treated With a Selective Serotonin Reuptake Inhibitor” and “Carotid Plaques From Symptomatic Patients Are Characterized by Local Increase in Xanthine Oxidase Expression.” She also interviews Drs. Jukka Putaala and Markku Kaste about their article “Should Tenecteplase be Given in Clinical Practice for Acute Ischemic Stroke Thrombolysis?”. Dr. Negar Asdaghi: 1) Are we ready to say goodbye to our old friend alteplase and replace it with a new one, tenecteplase, for acute stroke thrombo...2021-09-1631 min
Stroke AlertStroke Alert August 2021On Episode 7 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2021 issue of Stroke: “Stroke Risks in Adult Survivors of Preterm Birth: National Cohort and Cosibling Study” and “Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm.” She also interviews Drs. Nirav Bhatt and Diogo Haussen about their article “Reliability of Field Assessment Stroke Triage for Emergency Destination Scale Use by Paramedics: Mobile Stroke Unit First-Year Experience.” Dr. Negar Asdaghi: 1) Can preterm birth be associated with increased risk of stroke in adulthood? 2) Can a plant-based diet high in phytoestr...2021-08-1926 min
Stroke AlertStroke Alert July 2021On Episode 6 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2021 issue of Stroke: “Prevalence and Clinical Correlates of Intracranial Dolichoectasia in Individuals With Ischemic Stroke” and “Dose Escalation and Safety of Capsaicin for Cerebral Perfusion Augmentation.” She also interviews Dr. Osama Zaidat about his article “Impact of Age and Alberta Stroke Program Early Computed Tomography Score 0 to 5 on Mechanical Thrombectomy Outcomes.” Dr. Negar Asdaghi: 1) Is intracranial dolichoectasia the new intracranial atherosclerotic disease? 2) What is the latest on collateral flow improvement through sphenopalatine ganglion stimulation in patients with acute i...2021-07-1538 min
Stroke AlertStroke Alert June 2021Stroke Alert June 2021 On Episode 5 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2021 issue of Stroke: "Preexisting Mild Cognitive Impairment, Dementia, and Receipt of Treatments for Acute Ischemic Stroke” and “Body Mass Index in 1.9 Million Adolescents and Stroke in Young Adulthood.” She also interviews Dr. Shyam Prabhakaran, from the University of Chicago, about his article "Predictors of Early Infarct Recurrence in Patients With Symptomatic Intracranial Atherosclerotic Disease." Dr. Negar Asdaghi: 1) Do people with mild cognitive impairment receive the same quality of stroke care as their cognitively normal...2021-06-1724 min
Stroke AlertStroke Alert May 2021On Episode 4 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two featured articles from the May 2021 issue of Stroke: “Association of Serum IL-6 With Functional Outcome After Intracerebral Hemorrhage” and “SARS-CoV-2 and Stroke Characteristics: A Report from the Multinational COVID-19 Stroke Study Group.” This episode also features a conversation with Dr. Alvaro Garcia-Tornel Garcia-Camba to discuss his article “Ischemic Core Overestimation on Computed Tomography Perfusion.” Dr. Negar Asdaghi: 1) Can a pro inflammatory marker predict the hematoma size and clinical outcomes in patients with intracerebral hemorrhage? 2) What are the characteristics of stroke patients inf...2021-05-2021 min
Stroke AlertStroke Alert April 2021On Episode 3 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two featured articles from the April 2021 issue of Stroke. This episode also features a conversation with Dr. Simon Nagel, from Heidelberg University in Germany, to discuss his article “Predictors for Failure of Early Neurological Improvement After Successful Thrombectomy in the Anterior Circulation.” Dr. Negar Asdaghi: 1) Is Andexanet a cost-effective treatment for the reversal of coagulopathy in factor Xa-associated intracranial hemorrhage? 2) Are statins safe and efficacious in secondary prevention of stroke in the elderly population? 3) What are the predictors of futile recanalization among...2021-04-1521 minStroke AlertStroke Alert March 2021On Episode 2 of the Stroke Alert podcast, host Dr. Negar Asdaghi highlights two featured articles from the March 2021 issue of Stroke. This episode also features a conversation with Dr. Joan Montaner from Neurovascular Research Laboratory at the Universitat Autònoma in Barcelona, Spain, to discuss his article “D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke.” Dr. Negar Asdaghi: Can your microRNA profile predict your future risk of stroke? Is stroke that wake-up call to finally live a healthier lifestyle, better diet, exercise more, and stop smoking? Can a simple blood test improve ou...2021-03-1217 minStroke AlertStroke Alert February 2021On Episode 1 of the Stroke Alert podcast, host Dr. Negar Asdaghi highlights two featured articles from the February 2021 issue of Stroke. This episode also features a conversation with Drs. Fabian Flottmann and Matthew Maros from the Department of Diagnostic and Interventional Neuroradiology, University Medical Center, in Hamburg, Germany, to discuss their article “Good Clinical Outcome Decreases With Number of Retrieval Attempts in Stroke Thrombectomy: Beyond the First-Pass Effect.” Dr. Negar Asdaghi: Are women more likely to suffer from stroke than men? Are oral anticoagulants safe in atrial fibrillation patients with a prior history of GI bleeding?2021-03-0219 min