Shows
The Biology BriefSHOCKING Truth About Thalidomide's Dark Past and Remarkable Comeback! The Bio Brief episode 12
Delve into the historical impact of Thalidomide in Episode 12 of "The Biology Brief" with insightful anecdotes from Dr. Jim Cardelli and Kiley Grant. From its origins in mid-1950s Germany to the devastating consequences leading to its ban in 1961, explore the intended uses and the profound fallout that reshaped the FDA's drug approval regulations. Learn about Francis Kelsey's heroic stance at the FDA, preventing Thalidomide approval in the US and avoiding potential tragedies. Uncover the overlooked clinical trials in the US, the disastrous outcomes, and the profound effects on the FDA's oversight. Understand how this repurposed drug evolved from...
2024-03-0646 minThe Biology BriefYou Might Be Eating Too Much Protein - The Biology Brief Ep 11Learn the intricate world of cardiovascular health in Episode 11 of "The Biology Brief" with hosts Kiley Grant and Dr. Jim Cardelli. Explore the role of mTOR in cardiovascular disease and the fascinating link between protein consumption and mTOR activation.
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2:33 Overview of cardiovascular disease and role of mTOR in this process
5:50 High levels of consumed protein can activate mTOR
6:34 How much is too much protein?
9:45 The amino acid leucine is the key compound that induces mTOR and is found in high levels in meat and milk products
11:10 Some...
2024-02-2833 minThe Biology BriefThe Rise and Fall of Vitamin D - The Biology Brief ep 10
Expand your knowledge about the intricacies of Vitamin D in Episode 10 of "The Biology Brief." Join hosts Kiley Grant and Dr. Jim Cardelli as they explore Vitamin D production in the body, assess its dietary implications, and question national deficiency. Understand how our body manages Vitamin D, its 2020 surge in popularity, and the potential anti-inflammatory benefits. Reflect on the self-correcting nature of science, the risks of overdosing, and the crucial role of dosage in determining toxicity.
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0:00 Introduction to Vitamin D
1:16 Observational studies and how they...
2024-02-2241 minThe Biology BriefNavigating Senescence: The Biology Brief ep 9Delve into the complexities of aging in the latest episode of "The Biology Brief," where hosts Kiley Grant and Dr. Jim Cardelli, the CEO and CTO of Oleolive, unravel the significance of senescence and explore the hallmarks of aging. In this thought-provoking discussion, we examine the dual nature of senescent cells, their positive roles in wound healing and potential positive role in cancer. Join us as we navigate the intriguing connections between senescent cells, exercise, and revolutionary CAR T therapy. Learn about UPAR as the target of CAR T cells, its associated costs, and the challenges in measuring the...
2024-02-1443 minThe Biology BriefPsychedelics for Psychotherapy - The Future is Now: The Biology Brief Ep 8Explore the realm of psychedelic therapy in Episode 8 of "The Biology Brief." Join hosts Kiley Grant and Dr. Jim Cardelli as they analyze a groundbreaking paper on MDMA and PTSD, discussing flaws and the promising Phase 3 trial success. The episode covers the history of MDMA, clinical trials for PTSD, and potential FDA approval. Trace the evolution of psychedelic research from the 50s, dissect treatment protocols, and delve into the impact of various psychedelics. Learn about the formation of new neural connections with MDMA and Psilocybin, discuss adverse events, and contemplate the societal impact of creating drugs from natural products.
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2024-02-0741 minThe Biology BriefAlzheimer's Disease: Are we turning the corner? - The Biology Brief ep 7Welcome to "The Biology Brief," your passport to the forefront of biology and innovation, proudly presented by Oleolive. Dive deep into the intricate world of Alzheimer's disease with Kiley Grant and Dr. Jim Cardelli in Episode 7 of "The Biology Brief" podcast! Join us as we unravel the foundations, breakthroughs, and challenges surrounding this complex condition. From New Antibody Therapeutics to the impact of Aducanumab, we explore the latest in Alzheimer's research. Discover the link between Alzheimer's and Type 2 Diabetes, delve into cutting-edge insights on Tau, and grasp the concept of Type 3 Diabetes. Explore global perspectives on Alzheimer's prevalence, biomarkers...
2024-01-3145 minThe Biology BriefDo Viruses Cause Neurodegenerative Diseases? - The Biology Brief Ep. 6Welcome to "The Biology Brief," your passport to the forefront of biology and innovation, proudly presented by Oleolive. In this episode of "The Biology Brief," we delve into groundbreaking research that investigates the intriguing connections between viral exposures and the risk of neurodegenerative diseases. Recent findings have highlighted the Epstein-Barr virus's association with an increased risk of multiple sclerosis, coupled with growing concerns about the neurological impact of the coronavirus pandemic. Join us on this captivating exploration where science meets the future, only on "The Biology Brief." Stay informed, stay curious!
Read the paper:
https://pubmed.ncbi.nlm.nih...
2024-01-2431 minThe Biology BriefThe Biology Brief Ep. 5 - The Scientific Method: Unraveling Truths, Flaws, and InnovationsWelcome to "The Biology Brief," your passport to the forefront of biology and innovation, proudly presented by Oleolive. In this episode, your hosts, Kiley Grant, CEO of Oleolive, and CTO Dr. Jim Cardelli, embark on an enlightening journey through the scientific method. From the foundational goal of observation to the resilience required when hypotheses go awry, Kiley and Jim unpack the intricacies of the scientific method. They explore the importance of curiosity, delve into the flaws of the scientific method, and stress the significance of acknowledging negative data. The episode navigates through the influence of media on public perception...
2024-01-1130 minThe Biology BriefThe Biology Brief Ep 4: GLP-1 Agonists, Their Benefits, Impact on the Market and Future of Treatment
Join us for a deep dive into the world of GLP-1 agonists in this 30-minute podcast-style discussion. We unravel the mysteries surrounding these powerful medications, shedding light on their remarkable benefits, potential pitfalls, and profound impact on the healthcare market.
Jim and Kiley delve into the science behind GLP-1 agonists, uncovering their transformative effects on both weight loss and diabetes management. From unraveling their mechanism of action to exploring their implications for patients' lives.
Discover how GLP-1 agonists are reshaping the landscape of diabetes treatment, offering new hope and possibilities for millions worldwide. We analyze their market impact, discussing...
2024-01-0430 minThe Biology BriefThe Biology Brief Ep. 3: CRISPR and the newest sickle cell therapy, CasgevyIn episode 3, we cover the first FDA approved CRISPR therapy, Casgevy. This therapy has set the stage for what we think may be a huge jump shift in the biotech market.
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2024-01-0428 minThe Biology BriefThe Biology Brief: Episode 2. Proteomics, Organs and AgingIn this episode of biology brief, Jim and Kiley review a recently published paper on organ aging signatures in the plasma proteome and how it affects your health.
Paper we reviewed: https://www.nature.com/articles/s4158...
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2024-01-0420 min
The Biology BriefThe Biology Brief: Episode 1 - Diet and LongevityIn this episode of biology brief, Jim and Kiley review a recently published paper on how changing your diet in middle and even later in life can add significant amounts of time to your life span.
Paper we reviewed: https://www.nature.com/articles/s43016-023-00868-w
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2023-12-2814 min
On The CuspOlive YouIn today's episode, Matt and Dave are speaking with Kylie Grant of Oleolive, a biotechnology company that produces olive oil-extracted oleocanthal for research and consumer products to address inflammation and disease.If you are health conscious and interested in ways to help aid a longer, healthier lifestyle, don't sleep on this episode!OleOlive's method of extracting and purifying Extra Virgin Olive Oil polyphenols such as Oleocanthal, has made its way into cosmetic products, supplements that are under development and into other products across the world that are making people healthier, look younger and eat better.
2023-02-1520 min