Shows
The Genetics PodcastEP 185: From newborn screening to lifelong data in an evolving genomics landscape with Madhuri Hegde of RevvityThis week on The Genetics Podcast, Patrick is joined by Madhuri Hegde, SVP and Chief Scientific Officer of Revvity. They discuss Revvity’s advances in ultra-rapid clinical-grade sequencing, opportunities, challenges, and global inequities in newborn screening, and the dilemma of resequencing versus long-term data storage.Show Notes: 0:00 Intro to The Genetics Podcast00:59 Welcome to Madhuri01:52 Rebranding Revvity as a healthcare company02:51 Advancements in sequencing and Revvity’s projects, including newborn screening tests and clinical ultra-rapid sequencing12:29 Opportunities and challenges for newborn sequencing and global inequ...2025-05-0140 min
Proteomics in ProximityA glimpse into product management and PMWC plans with Jenny SamskogWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-revealOlink tools and software· Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/· Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Prot...2025-01-2832 min
Proteomics in ProximityProteomics in hundreds of thousands: Prof Sir Rory Collins and Dr Chris WhelanWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software· Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/· Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to...2025-01-1748 min
Proteomics in ProximityDecoding Aging and the Environment with Cornelia van DuijnWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and softwareOlink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to...2024-11-1356 min
Proteomics in ProximityComplementarity of Mass Spec and PEAWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies UKB-PPP online resources developed by Nick Lehner and Maria Wörheidehttps://metabolomips.org/ukbbpgwas/ Metabolomics and Proteomics Core in Munich:https://www.helmholtz-munich.de/en/core-facility-overview/metabolomics-and-proteomicshttps://www.helmholtz-munich.de/core-facilitiesStefa...2024-03-0548 min
Longevity by DesignHow Our Blood Impacts Brain Aging and Alzheimer’s Disease with Dr. Tony Wyss-CorayIn this insightful episode of Longevity by Design, hosts Dr. Gil Blander and Ashley Reaver welcome Dr. Tony Wyss-Coray, a distinguished expert in neurology and brain aging. Dr. Wyss-Coray shares his journey from a childhood fascination with nature to becoming a leading figure in neuroscience and immunology. His initial interest in farming evolved into a passion for understanding the complexities of the human brain, particularly in the context of aging and neurodegenerative diseases.Dr. Wyss-Coray discusses his groundbreaking research on Alzheimer's disease and the aging brain. He dives into the intriguing discovery that factors in young blood...2024-01-241h 21
Proteomics in ProximityHow proteomics is shaping pharma strategiesWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software• Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/• Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn...2023-11-1643 min
Proteomics in ProximityProteogenomics of metabolic disease with Mine Koprulu and Dr. Claudia LangenbergWelcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources from this episode: Published study of primary focusKoprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946. https://pubmed.ncbi.nlm.nih.gov/36823471/ Laboratory, first author, and corresponding author of the study· Public Health University Research Institute (PHURI), a multidiscip...2023-10-2644 min
Proteomics in ProximityPan-cancer blood proteome profiling with María Bueno Álvez (SciLifeLab)Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources from this episode: Published study of primary focusÁlvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerberg L, Uhlén M. Next generation pan-cancer blood proteome profiling using proximity extension assay. Nat Commun. 2023...2023-10-0342 min
Proteomics in ProximityPredictive biomarkers for heart failureWelcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication:Girerd N, et al. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. 2023 May;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.009694 https://pubmed.ncbi.nlm.nih.gov/37192292/ Large-scale cardiovascular studies:· Heart “OMics” in AGEing (HOMAGE), a European-based consortium investigating biomarkers to predict heart failure and as drug targets for prevention: https://www.homage-hf.eu/· Ath...2023-08-1630 min
Proteomics in ProximityInterview about the UK Biobank with Dr. Christopher WhelanWelcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted article from the UK Biobank Pharma Proteomics Project (UKB-PPP): Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. 2023 Apr;75(4):544-552. doi: 10.1002/art.42376. Epub 2022 Dec 28. PMID: 36239377. https://pubmed.ncbi.nlm.nih.gov/36239377/ Highlighted platform that was used to measure proteins...2023-07-2736 min
NanalyzeProteomics Stocks - The Latest News & Updates
Stay informed with our free disruptive technology investing newsletter, Nanalyze Weekly. Signup now at https://www.nanalyze.com/nanalyze-weekly/. This episode is pulled from a YouTube presentation. View the original presentation at https://youtu.be/_xvgD9x0t3Y.
Proteomics stocks like Codexis CDXS, Seer SEER, Somalogic SLGC, Olink OLK, Quanterix QTRX, Nautilus Biotechnology NAUT, and Quantum Si QSI have attracted lots of attention from retail investors who see the potential in studying the world of proteins - a field referred to as proteomics. It's been about a year since we last checked in with these seven...2023-06-2818 min
Proteomics in ProximityEmpowering breast cancer proteomics with genomics with Dr. Jochen SchwenkWelcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: https://doi.org/10.21203/rs.3.rs-2749047/v1 Highlighted platform that was used to measure proteins in this study with a next-generation sequencing (NGS) readout (Olink® Explore 3072): https://olink.com/products-services/explore/ Learn more about the consortiums or cohorts mentioned in the podcast: UK Biob...2023-05-3144 min
Proteomics in ProximityDUOX2, IL-17C, and IBD (Inflammatory Bowel Disease)Welcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. J Clin Invest. 2021 May 3;131(9):e141676. doi: 10.1172/JCI141676. PMID: 33651715; PMCID: PMC8087203. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087203/Hi...2023-05-1230 min
The Genetics PodcastEP 97: Proteomics deep dive with Cindy Lawley (Olink)In this episode, Patrick is joined by Cindy Lawley, Senior Director of Population Health at Olink Proteomics and co-host of the Proteomics in Proximity podcast. Cindy has worked with major population genomics programs, including the UK Biobank, to bring together proteomics, genomics, and deep phenotyping using the Olink platform.
Olink is one of the most promising proteomics technologies on the market, and the platform has been used in >1,000 publications, including landmark work in the UKBiobank to integrate genomics and proteomics.
The largest Olink assay currently covers around 3,000 proteins, and the scale continues to grow, while costs are decreasing, paving the...2023-04-261h 00
Proteomics in ProximityExercise and PrediabetesWelcome to Olink Proteomics in Proximity Podcast! Below are some useful resources from this episode: Highlighted publication: Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Rep Med. 2023 Feb 21;4(2):100944. doi: 10.1016/j.xcrm.2023.100944. Epub 2023 Feb 13: https://www.cell.com/cell-reports-medicine/pdf/S2666-3791(23)00036-8.pdf PMID: 36787735; PMCID: PMC9975321: https://pubmed.ncbi.nlm.nih.gov/36787735/ Highlighted platform that was used to measure proteins in this study with a ne...2023-04-1927 min
Africa Biotech ConversationsOlink: Revolutionising Disease Research in Africa In this episode of the Africa Biotech Conversation podcast, host Adrienne Leussa speaks with Cindy Lawley, Sr Director, Global Population Health of the Proteomics Company, Olink. Cindy shares insights on her background, the technology of Olink, and its potential impact on understanding genetic risks of diseases. In this episode, we learn of the first deployment of Olink's technology on the African continent at the Institute of Infectious Disease and Molecular Medicine (IDM) in Cape Town, South Africa. Cindy joined Olink in 2020 soon after the launch of the Explore Platform that leverages Next Generation Sequ...2023-03-311h 06
Proteomics in ProximityMechanism of Action of an SGLT2 InhibitorHighlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi:10.1093/eurheartj/ehac495. PMID: 36017745; PMCID: PMC9769969.Review paper of research by Voltar Longo and David Sinclair on longevity and aging, mentioning sirtuins and mTOR. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon...2023-03-1526 min
Proteomics in ProximityOlink Flex with Katarina HornaeusAll about Olink Flex: https://olink.com/flexOlink Insight (where you can build a 21-plex Olink Flex panel from 200 proteins): https://insight.olink.com Sweden’s Science for Life laboratory website: https://www.scilifelab.se/about-us/In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here.Would you like to subscribe to the podcast on your favorite pla...2023-02-1632 min
Proteomics in ProximityLIF - A Predictor of Immunotherapy ResistancePrimary reference: Loriot Y and Italiano A et al. Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance. Ann Oncol. (2021) 32(11):1381-1390. doi:10.1016/j.annonc.2021.08.1748Olink Insight Knowledge Platform with Hilda Andersson, Episode 6, Proteomics in Proximity. Description of the MATCH-R clinical trial, “A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents (MATCH-R)”, NCT02517892In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Pr...2023-02-0326 minProteomics in ProximityA Biomarker of Hereditary Transthyretin-Mediated AmyloidosisPrimary reference: Ticau S and Nioi P et al. (2021) Neurofilament Light Chain as a Biomarker of Hereditary Transthyretin-Mediated Amyloidosis. Neurology. 96(3):e412-e422. doi:10.1212/WNL.0000000000011090Information about the APOLLO clinical trial: “APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis” Link to NCT01960348 at the US National Library of Medicine’s Clinical Trials database https://clinicaltrials.gov/ct2/show/NCT01960348Epstein Barr Virus research presenting a stronger link between EBV and Multiple Sclerosis.Bjornevik K and Ascherio A et al. (2022) Longitudinal analysis reveals...2023-01-2026 minProteomics in ProximityBRCA2 CrisisThe 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here.Dr. Michael Snyder’s Stanford laboratory home page is here.A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here. A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required for Genomic Stability” is located here. And more about TIP60 can be found in this recent 2022 Oncogenesis reference, “The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells” located online her...2022-12-2118 min
Proteomics in ProximityDiscussing the Proteome with Dr. Karsten Suhre of Weill Cornell Medicine QatarPrimary reference: Suhre K, Sarwath H, Engelke R, Sohail MU, Cho SJ, Whalen W, Alvarez-Mulett S, Krumsiek J, Choi AMK, Schmidt F. Identification of Robust Protein Associations With COVID-19 Disease Based on Five Clinical Studies. Front Immunol. 2022 12:781100. doi:10.3389/fimmu.2021.781100Dr. Karsten Suhre’s Weill Cornell Medicine laboratory page: https://vivo.weill.cornell.edu/display/cwid-kas2049Leukemia Inhibitory Factor reference: Loriot Y, Marabelle A, Guégan JP, et al. Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance. Ann Oncol. 2021 32(11):1381-1390. doi:10.1016/j.annonc.2021.08.1748...2022-12-0746 minProteomics in ProximityOlink Insight knowledge platform with Hilda AnderssonTo access Olink Insight free of charge, visit https://insight.olink.com The first two data stories, with Normal Range data and COVID-19 data, has been recently updated with the first Disease Atlas, with data characterizing 15 cancer types. This is available on Olink Insight here: https://insight.olink.com/data-stories/disease-atlas-cancerTo access the COVID-19 Data Story dataset itself, information about the study and how to access the data is available on our website here: https://olink.com/application/mgh-covid-19-study/If you would like to contact Dale, Cindy o...2022-11-2339 minProteomics in ProximityLive from the American Society of Human Genetics (#ASHG22)List of names and affiliations mentioned in the UK Biobank context: Mark McCarthy (Genentech), Slavé Petrovski (AstraZeneca), Chris Whelan (Johnson and Johnson), Erin Smith (Takeda Pharmaceuticals), Melissa Miller (Pfizer), Ben Sun (Biogen).The ASHG announcement, honoring Sir Peter Donnelly, CEO of Genomics plc and Emeritus Professor of Statistical Science at the University of Oxford with the William Allan Award. A list of the many abstracts and plenary presentations at ASHG 2022 that mention Olink can be found here (PDF). The Ben Sun et al. preprint mentioned is titled “Genetic regulation of the human plasma prote...2022-11-0923 min
Proteomics in ProximityCelebrating 1,000 Olink Publications with Ida GrundbergOne of the first publications using Olink technology came out by Enroth S and Gyllensten U et al. Nature Communications 2014 “Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs”. Link to the paper is here: DOI:10.1038/ncomms5684To access the Olink Insight platform for protein biomarker data discovery free-of-charge with an email address, click here: https://insight.olink.com And be sure to check out the Publication Explorer!A recent publication by the same group from the University of Uppsala is by Gyllensten U and Enroth S et a...2022-11-0338 minProteomics in ProximityProteomic Profiling PlatformsThe 2022 Science Advances paper, “Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods” by Daniel H Katz and Rob Gerszten et al. is available online here.A highly informative Twitter thread by the first author Dr. Daniel Katz reviewing the figures of the paper is available here.If you are interested in learning more about the use of proteomics in multiomic strategies, here’s link to the Olink website where examples of combinations of omics methods are combined.If you would like to contact Dale, Cindy...2022-10-2532 minProteomics in ProximityEmpower Genomics with ProteomicsShow Notes for PiP Ep 02 “Empower Genomics with Proteomics”For more information about the UK Biobank, an Olink to Science blog post called “Genetic Regulation of the Human Plasma Proteome in the UK Biobank” is available here. The preprint publication itself is available here on bioRxiv. If you’d like to see a great 15 minute presentation on what the goals are for the UK Biobank Pharma Proteomics Project, Dr. Chris Whelan (Biogen) presented this YouTube video at one of the UK Biobank’s scientific meetings that is worth watching.A paper discussed by Folkersen et...2022-10-1239 minProteomics in ProximityIntroduction to Proteomics in ProximityIn case you would like to learn more about our backgrounds, Cindy’s LinkedIn is here, Sarantis’ is here, and Dale’s is here.For more information about the UK Biobank, an Olink to Science blog post called “Genetic Regulation of the Human Plasma Proteome in the UK Biobank” is available here. The preprint publication itself is available here on bioRxiv. If you’d like to see a great 15 minute presentation on what the goals are for the UK Biobank Pharma Proteomics Project, Dr. Chris Whelan (Biogen) presented this YouTube video at one of the UK Biobank’s scientific m...2022-09-2736 min
Proteomics in ProximityThe Proteomics in Proximity Podcast TrailerCo-hosts Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas from Olink Proteomics talk about the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. In case you were wondering, "in Proximity" refers to Olink's underpinning technology called the Proximity Extension Assay, to allow highly multiplexed protein analysis from small sample volumes for pharmaceutical, clinical translation and academic research. More information about PEA can be found here on Olink's website.If you have any questions or comments, feel free...2022-09-1901 min
Law LightS4 E8: Diversity & Inclusion Series with Linda RamirezThis week Linda Ramirez, the General Counsel and Board Secretary at Olink Proteomics and Board Member of Latinas First Foundation, joins Gibson Arnold’s CEO, Melinda Delmonico, in sharing her journey and struggles of the legal world. Her various experiences, personal and professional, have given her a unique perspective on DEIA and equipped her to tackle the challenges of diversity that many people face. Linda’s message: Know Your Worth! This episode answers questions like:How do you define diversity and inclusion? How do you carry it out?Who an...2022-05-2742 min