Shows
To Immunity and BeyondOptimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexesProfessor Omer Dusk discusses a bioRxiv pre-print: ‘Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes’. This episode discusses the following pre-print: 'Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes.' Burton J, Siller-Farfan JA, Andre V, Jenkins J, Barton MI, Bustamante Eguiguren S, Cabezas-Caballero J, Davis SJ, Weikl TR, van der Merwe PA, Dushek O (bioRxiv pre-print (2025), under review).
And references two related studies that provide foundational framework for the work:
Using CombiCells, a platform enabling titration and combinatorial display of cell surf...2025-01-0928 minTo Immunity and BeyondOptimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexesProfessor Omer Dusk discusses a bioRxiv pre-print: ‘Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes’. This episode discusses the following pre-print: 'Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes.' Burton J, Siller-Farfan JA, Andre V, Jenkins J, Barton MI, Bustamante Eguiguren S, Cabezas-Caballero J, Davis SJ, Weikl TR, van der Merwe PA, Dushek O (bioRxiv pre-print (2025), under review).
https://www.biorxiv.org/content/10.1101/2025.01.06.631424v1
And references two related studies that provide foundational framework for the work:
Using CombiCells, a platform enabling titr...2025-01-0928 min