Shows
The Optispan Podcast with Matt KaeberleinPreventive Failure: How Modern Healthcare Misses Disease EarlySubscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at Optispan to catch risks early and optimize long-term health. From advanced diagnostics to lifestyle pillars and evidence-based medications, learn how to shift from treating disease to building resilience.🔬 Topics Covered:The moment Dr. Byrne realized traditional medicine was focused on the wrong end...
2026-01-071h 11The Optispan Podcast with Matt KaeberleinDr. Stanfield Mortgaged His House For $150k To Prove Longevity Drug WorksIn this in-depth conversation, Dr. Brad Stanfield sits down with Dr Matt Kaeberlein to discuss his journey from a primary care physician in New Zealand to a leading voice in the evidence-based longevity space. We cover the launch and philosophy behind his YouTube channel, the challenges and exciting results of his self-funded rapamycin clinical trial, and his critical perspective on supplements, medical guidelines, and the future of aging research.Dr. Stanfield provides a unique clinician's viewpoint on hot topics like GLP-1 agonists (Ozempic), SGLT2 inhibitors, vitamin D testing, and the pitfalls of biological age clocks. We also...
2025-11-111h 13The Optispan Podcast with Matt KaeberleinDon't Fall For This Scam: Matt's Deepfake PSASubscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based...
2025-11-0609 minThe Optispan Podcast with Matt KaeberleinDoctor Reveals: The Dark Side of the Longevity IndustryJust back from the tour of the longevity world! In this episode, we discuss my recent travels to two major conferences: the high-end Longevity Investors Conference in Gstaad, Switzerland, and the academic GJAM Conference in Jena, Germany.We unpack the stark contrasts between these two worlds, from the venues and treatment of attendees to the fundamental divides in how people perceive and practice "longevity." I share my key takeaways on the growing chasm between real science and snake oil, the "apologist" perspective, and why I believe the term "Longevity Medicine" is already developing a bad reputation.
2025-10-1553 minThe Optispan Podcast with Matt KaeberleinAI Medicine: ChatGPT Reads Blood Tests Faster Than Your DoctorSubscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork?In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, the rise of AI in medicine, and how people are consuming health information today. From internet “gurus” to tools like ChatGPT, they explore where people are searching for health answers, and whether those answers are truly helpin...
2025-09-231h 23The Optispan Podcast with Matt KaeberleinIs Creatine Harming Your Kidneys? The Blood Test Myth Explained.Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, and reveals a more accurate blood marker you should know about.0:00 - The Creatine Dilemma1:00 - My Alarming Blood Test Results1:37 - Creatinine & EGFR: The Standard Test4:40 - The Better Marker: Cystatin C Explained6:32 - Proof: The Follow-Up Test7:35 - Who Else Is at Risk for a...
2025-09-1609 minThe Optispan Podcast with Matt KaeberleinMagic Mushrooms: The Next Anti-Aging Drug?Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential biological mechanisms that could connect psychedelics to the aging process.0:00 - Why I'm Talking About Psilocybin3:08 - The Science of Psilocybin & Serotonin6:36 - Breaking Down The New Paper10:09 - The "Psilocybin Telomere Hypothesis"12:02 - The Cell Study: A Critical Look17:51 - The Lifespan Study in Mice (The Main...
2025-09-0432 minThe Optispan Podcast with Matt KaeberleinA Scientific-Backed Discussion On Fighting Cognitive DeclineSubscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Today Dr. Kevin White and Erik Nelson join us for a deep-dive conversation as they unveil a new, multi-faceted program designed to halt and even reverse cognitive decline. They break down the key diagnostics, lifestyle pillars, and advanced therapies that form the foundation of their science-backed blueprint for brain health.0:00 - The Mission: Why We're Tackling Dementia16:14 - The Diagnostic Blueprint: Blood, Brain Scans & Cognitive Tests40:44 - The Foundation: Lifestyle as Brain Armor49:28 - Level 1: The Core Supplements for Brain Health56:59...
2025-09-021h 24The Optispan Podcast with Matt KaeberleinDebunking 10 Longevity Myths You Still Believe | 126Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements, this episode separates scientific fact from expensive fiction.0:00 - Intro: A New Series on Longevity Myths0:49 - Myth 1: Can You Actually "Measure" Biological Age?5:05 - Myth 2: Are Supplements a "Core" Longevity Strategy?6:29 - Myth 3 & 7: "I'm Too Old" & The Role of Your Genes8:16 - Myth 4 & 6: The...
2025-08-2837 minThe Optispan Podcast with Matt KaeberleinTestosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on diet strategies, supplements, and body composition, separating fact from fiction for those looking to optimize their health.0:00 - Intro: The ITP Water Bottle2:52 - My Testosterone Protocol (Dose, Injections & What I Avoid)10:05 - Testosterone for Women?12:32 - Rapamycin Q&A (Dose, Side Effects & Cycling)18:45 - The Problem with 50+ Supplements20:55...
2025-08-1940 minThe Optispan Podcast with Matt KaeberleinBrain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’s risk decades in advance. Discover the impact of lifestyle factors like diet, exercise, and sleep on cognitive decline, plus the latest in medications, including GLP-1 agonists and hormone replacement therapy.0:00 - Introduction to NeuroAge & Brain Aging2:50 - Understanding the Brain Age Clock & Alzheimer's Risk6:30 - The Role of Genetics in Bra...
2025-03-181h 00The Optispan Podcast with Matt KaeberleinCrypto-Powered Science: How Blockchain & DAOs Are Reimagining Longevity Research | 97Subscribe to our channel: https://www.youtube.com/@optispan
In this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous Organizations), tokenized intellectual property, and how this model might revolutionize scientific collaboration and fundraising.
0:00 What is Molecule AG?
3:16 How Tokenized IP Works
10:30 Challenges and Trust in Crypto
25:00 Introduction to Pump.Science
39:05 The Road to Mice Experiments
42:26 Future of Pump.Science and Scaling Up
54:26 Vision for the Future
...
2025-02-061h 00The Optispan Podcast with Matt KaeberleinPeter Attia: Training, Eating & Optimizing To Live Longer & Healthier In 2025 | 96Subscribe to our channel: https://www.youtube.com/@optispan
In this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on processed foods, alcohol, and the limitations of trendy approaches like epigenetic clocks.
Other topics discussed are interventions such as hormone therapy, rapamycin, metformin, and NAD boosters, offering insights...
2025-01-231h 17The Optispan Podcast with Matt KaeberleinLIVE AMA: Longevity Scientists Answer Your Health & Longevity Questions LIVE | 92
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In this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the FDA’s stance on aging. They address emerging ideas such as leveraging AI for aging research, the importance of lifestyle factors like diet and sleep, and the need for actionable biomarkers. The session is a candid exchange of expert opinions, tackling scientific co...
2025-01-021h 38
The Optispan Podcast with Matt KaeberleinMEGA Q&A: We Answer 30 of Your Health & Longevity Questions | 90 PART 1Subscribe to our channel: https://www.youtube.com/@optispan
In this Part 1 episode, Matt and Brian Kennedy cover various aspects of aging research, including the connection between the immune system and aging, the role of inflammation, the potential of supplements and wearables in healthspan, and insights on longevity interventions. They also discuss the challenges in the field regarding clinical practices, the influence of AI on aging research, and personal experiences with health optimization.
This is Part 1 of a two-part series—stay tuned for even more in the next episode.
00:00 Intro
02:02 What is the connection between the immune system and ag...
2024-12-191h 27The Optispan Podcast with Matt KaeberleinI Got a Full Body MRI: IS IT WORTH IT? I Share My Results | 89Subscribe to our channel: https://www.youtube.com/@optispan
In this episode of the Optispan Podcast, Matt Kaeberlein shares his experience of undergoing a whole body MRI, discussing its potential as a screening and preventative tool for health optimization. He covers the benefits and drawbacks of whole body MRIs, shares specific details about his experience with the provider Ezra, and reflects on his results, emphasizing the importance of having quality follow-up care. Kaeberlein concludes with advice on avoiding overpriced MRI packages marketed by influencers.
0:00 Introduction to Whole Body MRI.
1:03 Why Whole Body MRI is considered for health optimization.
2:06 Integration...
2024-12-1729 minThe Optispan Podcast with Matt KaeberleinUnderstanding Women's Hormonal Health, Hormonal Changes & How Hormone Replacement Therapy Can Help | 88In the final installment of this three-part series, Matt and Kim Celmer explore the essential topic of hormonal health for women, highlighting its impact on both overt and silent symptoms of hormonal changes. Celmer offers practical advice for initiating meaningful conversations with healthcare providers about hormone levels with both diving into the intricacies of hormone replacement therapy (HRT)—what it is, how it works, and its potential benefits and risks. Addressing public concerns, they discuss the relationship between HRT and breast cancer, dosing considerations, and what care might look like for women seeking treatment. The episode concludes with thought-provoking qu...
2024-12-1246 min
The Optispan Podcast with Matt KaeberleinLongevity Scientist On Ethan Klein's "Revolutionary New Drug For Dogs" Discussion (H3 Podcast) | 87
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Matt Kaeberlein & Nick Arapis discuss the potential of new drugs aimed at extending the lifespan of dogs and cats. The conversation highlights recent advancements, including Loyal’s injection-based treatment targeting the IGF-1 hormone, which may add years to a dog’s life. They also address misconceptions regarding claims about cat lifespan extensions, emphasizing the lack of scientific backing for such assertions. The episode underscores the importance of grounded scientific communication and the excitement surrounding longevity-based advancements.
0:00 - Intro to the episode
1:10 - Mention of cat lifespan drug claims
3:00 - Overview of r...
2024-12-1014 min
The Optispan Podcast with Matt KaeberleinEpigenetic & Glycan Age Tests Results: Are Biological Age Tests Accurate? | 86
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In this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers, the impact of lifestyle on aging metrics, and the challenges of interpreting results. The discussion emphasizes the need for caution in marketing claims and the importance of scientific validation in biological age testing.
00:00 - Intro
00:36 - Discussion on biological age tests
04:10 - Defining biomarkers...
2024-12-0550 min
The Optispan Podcast with Matt KaeberleinCold Plunge & Brown Fat, Different Types of Stress, and The Power of The Mind | 85Subscribe to our channel: https://www.youtube.com/@optispan
In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resilience shapes our responses to stress, the importance of hormesis in health, and the role of brown fat in metabolism. We also discuss the impact of fasting, caloric restriction, and the relationship between mitochondrial health and aging.
00:00 - Introduction to Cold...
2024-12-031h 07
The Optispan Podcast with Matt KaeberleinI Took 4 Different Biological Age Tests & Compared the Results... | 82Subscribe to our channel: https://www.youtube.com/@optispan
Related Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW
In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental design to evaluate the accuracy and precision of these tests, addressing important questions about what they truly measure and how reliable they are. Matt unpacks the difference between biological and chronological age, discusses the co-marketing strategies employed by these companies, and...
2024-11-2137 min
The Optispan Podcast with Matt KaeberleinDr Seager: Rethinking Health for Longevity | 81Subscribe to our channel: https://www.youtube.com/@optispan
In this episode, Matt sits down with Thomas Seager, an associate professor at Arizona State University (ASU), to explore the challenges and future directions of healthcare. Drawing from his background in environmental engineering and public health, Thomas discusses the pressing health issues affecting longevity in Americans and a potential shift from a reactive healthcare model to one that emphasizes proactive health management. Together, Matt and Thomas examine the complexities of early disease detection, the promise and limitations of AI in analyzing biomarkers, and the difficulties of separating reliable information from...
2024-11-1946 min
The Optispan Podcast with Matt KaeberleinDeath, Grief, & Purpose from a Longevity Science Perspective | 80
Subscribe to our channel: https://www.youtube.com/@optispan
Grief: one of the most profound emotions humanity shares; a universal experience that transcends time, culture, and place; a phenomenon as ancient as human existence. Grief is as intrinsic to the human experience as joy or hope, and no one escapes it—to grieve is to be human.
In this episode, Matt and Nick discuss their recent personal experiences with grief and loss. Matt lost his German Shepherd Dobby to degenerative myelopathy, while Nick's father succumbed to health issues precipitated by heavy alcohol use. Together they explore how grief affects me...
2024-11-1449 min
The Optispan Podcast with Matt KaeberleinNutrition Myths, Gut Fixes, Natural Health Tips from a Doctor of Naturopathy | 79
Subscribe to our channel: https://www.youtube.com/@optispan
Related episode:
People are GETTING THIS WRONG about Supplements & My Supplement List: https://www.youtube.com/watch?v=_UXk_ynCNUs
In this episode, Matt sits down with naturopathic doctor and primary care provider Kim Celmer to discuss the distinct approach naturopathic doctors (NDs) bring to patient care, addressing common misconceptions about complementary and alternative treatment modalities and explaining how NDs treat prevalent issues like digestive problems, food sensitivities, and nutrient deficiencies. They dive into the distinctions between food allergies and sensitivities and how NDs manage these through a holistic lens...
2024-11-0734 min
The Optispan Podcast with Matt KaeberleinWe are Keeping People Sick Longer - We Need Medicine 4.0 | 78
Subscribe to our channel: https://www.youtube.com/@optispan
Related episode:
Defining "Healthspan" & its role in LIVING LONGER: https://www.youtube.com/watch?v=cI6CNFeBl88
Author and physician Peter Attia popularized the concept of "Medicine 3.0", the third in a series of distinct phases—Medicine 1.0 and Medicine 2.0 included—that describe the evolution of medicine as we know it.
In this episode, Matt takes us through these phases and proposes a "Medicine 4.0" as the best next step beyond Peter's Medicine 3.0. He discusses the reactive disease care approach of Medicine 2.0, noting that while it has done a stellar of job of incr...
2024-11-0525 minThe Optispan Podcast with Matt KaeberleinThe Probability of Us Living to Be Much Older? | 77
Subscribe to our channel: https://www.youtube.com/@optispan
How much longer might humans live?
This question has fascinated scientists, philosophers, and dreamers for centuries. The average human lifespan has already increased dramatically over the past hundred years thanks to advances in medicine, public health, and technology, and the prospect of radically extending human life remains one of humanity’s most compelling frontiers.
A recent paper published in the scientific journal Nature Aging argues that radical life extension is unlikely to happen in the 21st century. The paper has sparked fascinating conversation in the longevity industry around topics such as...
2024-10-3135 minThe Optispan Podcast with Matt KaeberleinLongevity Scientist Answers Burning Questions About Health Trends | 76
Subscribe to our channel: https://www.youtube.com/@optispan
Here's another Ask Matt Anything episode, with questions from Nick for Matt about topics ranging from the nitty-gritty of bloodwork and workout schedules to bigger-picture questions about upper limits to human lifespan, issues with the US healthcare system, and incentives for food companies to prioritize healthy options.
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is...
2024-10-3045 minThe Optispan Podcast with Matt KaeberleinBrain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain | 75
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM: https://www.youtube.com/watch?v=ebj-3MuAKRs
Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/
Matt and psychiatrist Jon Berner discussed the potential of rapamycin and ketamine for treating severe depression and chronic pain, focusing on their impact on microglia and brain inflammation. They touch on how microglia, a type of immune cell found in the central nervous system that help protect the brain against infections, clear debris, and respond to injuries, shifts from an inflammatory to...
2024-10-241h 02The Optispan Podcast with Matt KaeberleinAnti-Aging Enthusiasts are Taking this Pill to Extend Their Lives? | 73
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the New York Times article: https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html
Related episodes:
“Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: https://www.youtube.com/watch?v=-H6cDIl6pgo
NEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin for Longevity: https://www.youtube.com/watch?v=JUAXqSSnXzo
Matt and Nick discuss a recent New York Times article about rapamycin and its potential as a life-extending and/or anti-aging drug (the article quotes Matt). Matt answers various questions from Nick rela...
2024-10-1737 min
The Optispan Podcast with Matt KaeberleinDon't Drink Your Coffee First Thing in the Morning? | 71Subscribe to our channel: https://www.youtube.com/@optispan
Check out the study on caffeine and cortisol secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/?__hstc=3584879.1bb630f9cde2cb5f07430159d50a3c91.1522713601929.1522713601930.1522713601931.1&__hssc=3584879.1.1522713601932&__hsfp=1773666937
Check out James Hoffman's views on delaying caffeine intake in the morning: https://www.youtube.com/watch?v=yCJr49GU9yY
Coffee: one of the world's most popular beverages, a pick-me-up, a source of comfort and warmth, a symbol of energy and focus, a tool for social interaction. Global consumption adds up to billions of cups per day, and an estimated 75...
2024-10-1012 min
The Optispan Podcast with Matt KaeberleinMetformin Decelerates Aging Clocks & Slows Brain Aging? We Take a Look. | 70Subscribe to our channel: https://www.youtube.com/@optispan
Check out the paper: https://www.sciencedirect.com/science/article/pii/S0092867424009140?casa_token=6qa0LtsLh8QAAAAA:Iid3EX1qav1JTfkO5Skj787iUo6bJjD4dAgjvK_2ix5JirSEakRCc92m_W0G5CgNdLZR-RT4B4Q
In September 2024, the scientific journal Cell published a paper suggesting that metformin slows the pace of biological aging in male primates. Metformin is an FDA-approved prescription medication commonly used to treat type 2 diabetes by improving insulin sensitivity and decreasing the amount of glucose produced by the liver. After examining the influence of metformin supplementation on a suite...
2024-10-0814 min
The Optispan Podcast with Matt KaeberleinDoes Plant Protein Slow Your Aging? | 69 - Longevity This Week #12
Subscribe to our channel: https://www.youtube.com/@optispan
We recently came across a study published in the European Journal of Nutrition that examined the relationship between plant and animal protein intake and measures of biological aging. The study, which uses data from the UK Biobank, a long-term database of biological data from half a million participants in the United Kingdom, found that a higher plant protein intake correlates inversely with biological aging. Matt takes us through the study and gives us his take on the results and potential explanations for them as well as on the validity of...
2024-10-0321 min
The Optispan Podcast with Matt KaeberleinThe Dog Aging Project that aims at Helping Dogs Live Longer | 68 - DAP #2
Subscribe to our channel: https://www.youtube.com/@optispan
More about the Dog Aging Project: https://dogagingproject.org/
The Dog Aging Institute: https://dogaginginstitute.org
Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP
We get lots of feedback and questions about the Dog Aging Project (DAP) from viewers, so we wanted to provide an update about how the project is going as well as some context. In this episode, Matt dives into the project's winding 10-year history, which includes navigating the vagaries of government funding, handling skepticism from fellow academics, and...
2024-09-2655 min
The Optispan Podcast with Matt KaeberleinYou Should Focus on THESE 4 Things for Your Health & Longevity | 67 - HSM #9
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Current Healthcare ISN'T CUTTING IT: How Optispan is REVOLUTIONIZING it: https://www.youtube.com/watch?v=yc2kiKsm-Z0
Aging Expert Explains How Healthcare got it ALL WRONG: https://www.youtube.com/watch?v=PAEx-5CdX94
Your health doesn't need to be complicated. With so much conflicting information out there, it's easy to feel overwhelmed and unsure of what truly works. At the Optispan Podcast, we focus on cutting through the noise and providing you with clear, evidence-backed solutions that will make a noticeable difference in your life, rather...
2024-09-2421 minThe Optispan Podcast with Matt KaeberleinNEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin for Longevity | 66 - AMA #5
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the PEARL trial webinar with Dr. Z of AgelessRx, Oliver Medvedik of Genspace, and Matt Kaeberlein: https://www.youtube.com/watch?v=dEXBFlQOTf4&t=1217s
Check out the preprint discussing PEARL trial results after one year: https://www.medrxiv.org/content/10.1101/2024.08.21.24312372v1
Check out the PEARL trial listing: https://clinicaltrials.gov/study/NCT04488601
The AgelessRx-sponsored Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) trial was a 48-week randomized, double-blind, placebo-controlled trial investigating the safety and potential efficacy of different intermittent rapamycin doses for mitigating signs of aging...
2024-09-1955 min
The Optispan Podcast with Matt KaeberleinThis Study Says IL-11 Inhibitor Drug May Extend Lifespan | 64 - LTW #11
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the paper: https://www.nature.com/articles/s41586-024-07701-9.pdf
Related episodes:
The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY
A recent paper demonstrating that injecting older mice with an anti-IL-11 drug extended their median lifespan made a splash in the geroscience community this summer. IL-11 is a proinflammatory cytokine that plays a role in regulating various biological processes, including hematopoiesis (the production of blood cells), bone health and remodeling, and tissue repair. Meanwhile, cytokines act as messengers between...
2024-09-1258 min
The Optispan Podcast with Matt KaeberleinTrametinib & Rapamycin = Greater Effect on Lifespan? We Take a Look. | 63 - LTW #10
Subscribe to our channel: https://www.youtube.com/@optispan
Check out paper #1 on IL-11 signaling: https://www.nature.com/articles/s41586-024-07701-9.pdf
Check out paper #2 on combination trametinib/rapamycin treatment: https://www.biorxiv.org/content/biorxiv/early/2024/07/25/2024.07.25.605097.full.pdf
Related episodes:
An introduction to the study of RAPAMYCIN: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1s
In this episode, Matt discusses two recent mouse lifespan studies: one focused on inhibiting IL-11 signaling, and one focused on combined trametinib and rapamycin treatment. IL-11, or Interleukin-11, is a protein that plays an important role in modulating...
2024-09-1019 min
The Optispan Podcast with Matt KaeberleinMatt Kaeberlein reflects on "David Sinclair’s Longevity Lie" | 62 - Longevity Reacts #5
Subscribe to our channel: https://www.youtube.com/@optispan
Check out Scott Carney's channel: https://www.youtube.com/@sgcarney
Related episodes:
The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk
DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw
Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA
An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ
In this episode, Matt and Nick react to investigative journalist and author Scott Carney's video describing what he calls "David Sinclair's longevity lie" in the...
2024-09-051h 06
The Optispan Podcast with Matt KaeberleinDoes NMN Actually Increase VO2 MAX? | 61 - Longevity This Week #9
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA
Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN" https://youtu.be/OgsfIUfuyqk
NAD+ boosters are supplements designed to enhance levels of nicotinamide adenine dinucleotide (NAD+), a central coenzyme found in all living cells and involved in innumerable biochemical reactions that include DNA repair, glycolysis, stress responses, and more. As we age, NAD+ levels naturally decline. Supplements containing NAD+ precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) aim to counteract this...
2024-09-0324 min
The Optispan Podcast with Matt KaeberleinThe Horribly Under-Researched Science of Menopause, Ovarian Aging & HRT | 60 - Jennifer Garrison
Subscribe to our channel: https://www.youtube.com/@optispan
Check out Productive Health: https://productivehealth.org/
Check out the Garrison Lab: https://garrisonlab.com/
We had a great time hosting Dr. Jennifer Garrison from the Buck Institute for Research on Aging to talk about her areas of expertise: reproductive aging and neuropeptide signaling. Jennifer and Matt go over the fascinating and chronically under-researched science of menopause, misconceptions about hormone replacement therapy, and the importance of considering the endocrine function of the ovaries alongside their role in reproduction. They also chat about evolutionary questions around menopause, changes they would like...
2024-08-271h 36
The Optispan Podcast with Matt KaeberleinTrying Cold Plunge & Sauna w/ Mike Mutzel (Risks & Benefits Discussion)| 59 - Field Trip #1
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc
This summer, Matt and Nick visited MYOXCIENCE Nutrition founder and content creator Mike Mutzel at his home to give saunas and cold plunges a try. In this episode, they share their personal experiences with both, noting the mental and physical effects they experienced during and afterward, and emphasize the importance of considering both risks and rewards in healthspan interventions.
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended...
2024-08-2225 min
The Optispan Podcast with Matt KaeberleinResponding to Comments that Disagree with Us on Longevity | 58 - Correcting the Record #1
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk
Why Drinking a Banana Smoothie IS the Same as Eating a Banana: https://youtu.be/Dg7S33-75_E
Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN: https://youtu.be/OgsfIUfuyqk
Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc
Scientists Debate How to Live Longer & Longevity Drugs: https://t.co/UlXk3PgtXg
The Best Strategies for Living Longer RANKED: Longevity Tier List: https://youtu.be/OgsfIUfuyqk
Scientist Reacts to Greg Doucette's Controversial...
2024-08-1543 min
The Optispan Podcast with Matt KaeberleinScientist Reacts to Greg Doucette's Controversial Take on DEXA Scans | 57 - Longevity Reacts #4
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Why DEXA Scans Are NOT the HOLY GRAIL of BODYFAT Testing - Science Explained: https://www.youtube.com/watch?v=2Gg4Jm5KS1Y
Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko
The UNEXPECTED Ozempic Weight Loss Body Scan Results (DEXA): https://youtu.be/C_Z7qPVRA5M
Coach, bodybuilder, and powerlifter Greg Doucette published a video on his Youtube channel discussing what he sees as the shortcomings of DEXA scans and why DEXA scans are not, in his opinion, the gold...
2024-08-1337 min
The Optispan Podcast with Matt KaeberleinMost Longevity Experts Don't Tell You This About Aging | 56 - Longevity Science #8
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Biological Age & what it REALLY means: https://youtu.be/DcxgEwQKx8Q
The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw
The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY
An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ
Depending on how you look at them, aging genes are genes whose expression changes in a predictable with age or genes that influence an organism's lifespan by affecting various biological processes associated with aging. Research on aging...
2024-08-0832 min
The Optispan Podcast with Matt KaeberleinScientists Debate How to Live Longer & Longevity Drugs | 55 - Charles Brenner
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the Brenner lab: https://brennerlab.net
Related episodes:
The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY
Matt and City of Hope Alfred E. Mann Family Foundation Chair of Diabetes and Cancer Metabolism Charles Brenner have had several public disagreements on social media. We love a good conversation between two distinguished scientists whose views may not entirely align, so we were pleased to host Charles on the Optispan Podcast for a discussion of topics in geroscience ranging from whether sirtuins are actually...
2024-08-072h 20
The Optispan Podcast with Matt KaeberleinThis Company's New Longevity Senolytic Drug & The Drug Development Process | 54 - David Scieszka
Subscribe to our channel: https://www.youtube.com/@optispan
Check out Vertical Longevity Pharma: https://vertical-longevity-pharma.com/
Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field.
His last guest from the AGE meeting is David Scieszka, a longevity entrepreneur with a unique background that includes work as a PsyOps specialist for the US Army. David is currently working on Vertical Longevity Pharma, a senolytics company that he spun out from his postdoctoral work. He previously lead multiomics...
2024-08-0118 min
The Optispan Podcast with Matt KaeberleinA Longevity Breakthrough w/ Yamanaka Factor "Rejuvenation Cocktail?" | 53 - Longevity Reacts #3
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
You Can Live Longer!: https://www.aspenideas.org/sessions/you-can-live-longer
Estriol Shown to Increase Lifespan as Winner of Intervention Testing Program: https://youtu.be/1DQEuT0dtWk
The Best Strategies for Living Longer RANKED: Longevity Tier List: https://youtu.be/41WUYgEkQeA
Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4
In June 2024, the Aspen Ideas Festival held a three-day health-focused event in which speakers discussed new breakthroughs, policy developments, and possible futures in healthcare. "You Can Live Longer!" was a panel discussion during...
2024-07-3036 minThe Optispan Podcast with Matt KaeberleinThe Benefits of Protein Restriction, How Protein Affects Hormones & FGF21 | 51 - Cristal Hill
Subscribe to our channel: https://www.youtube.com/@optispan
Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field.
One of these was Cristal Hill. Cristal is an Assistant Professor of Gerontology at the University of Southern California Leonard Davis School of Gerontology, where she runs a lab focused on how dietary protein might affect adipose tissue (body fat) function, metabolic, and endocrine health during aging. Cristal received postdoctoral training at the Pennington Biomedical Research Center of Louisiana State...
2024-07-2348 min
The Optispan Podcast with Matt KaeberleinLongevity Scientist Critiques Mike Israetel's "Exercise Scientist Critiques" | 51 - Longevity Reacts
Subscribe to our channel: https://www.youtube.com/@optispan
Check out Mike Israetel's channel: https://www.youtube.com/@RenaissancePeriodization
Related episodes:
Exercise Scientist Critiques Bryan Johnson's INSANE Anti-Aging Protocol: https://www.youtube.com/watch?v=AAZespwbj6k
The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw
Entrepreneur and competitive bodybuilder Mike Israetel recently released a video discussing Bryan Johnson's anti-aging protocol. Towards the end of the video, he gives us his take on the "big rocks" that account for the bulk of our longevity.
In this episode, Matt reacts in real time to his first...
2024-07-2313 min
The Optispan Podcast with Matt KaeberleinLongevity Scientist Reacts to Bryan Johnson's "I Edited My DNA To Live Forever" |50-Longevity Reacts
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q
Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits".
In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's...
2024-07-1850 min
The Optispan Podcast with Matt KaeberleinStem Cells, Aging Hallmarks & Rapamycin | 49 - Kevin White
Subscribe to our channel: https://www.youtube.com/@optispan
Check out Prime Health Associates: https://www.primehealthassociates.com/
Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the gerosciencefield.
One of these was Kevin White, physician at longevity-focused clinic Prime Health Associates in Oklahoma City, Oklahoma. Kevin spent two decades in emergency medicine before obtaining fellowship training in integrative and functional medicine, nutrition, and age management. He complete residency training in emergency medicine and trauma at Washington University in St. Louis...
2024-07-1638 min
The Optispan Podcast with Matt KaeberleinDNA Damage, Senescence & Apoptosis | 48 - Aditi Gurkar
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the Gurkar lab: http://agresearchlab.com/
In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field.
One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging. Prior to setting up her lab at the University of Pittsburgh, Aditi conducted research on the impact of DNA damage on aging...
2024-07-111h 06
The Optispan Podcast with Matt KaeberleinAnswering Questions on Gold Standard Longevity Intervention RAPAMYCIN | 47 - AMA #4
Subscribe to our channel: https://www.youtube.com/@optispan
Help keep the Dog Aging Project alive (prizes available!): https://donor-list.org/go/QGkYGQcLFL
More about the Dog Aging Project: https://dogagingproject.org/
Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP
The Dog Aging Institute: https://dogaginginstitute.org
The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and...
2024-07-0941 min
The Optispan Podcast with Matt KaeberleinDebating a Doctor's Statement on NR & Rapamycin | 46 - X-Wars
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP: https://youtu.be/b4VaXqeli8c
Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN: https://youtu.be/OgsfIUfuyqk
We read every single comment on our social media and Youtube channels and enjoy hearing your feedback, questions, and comments on our podcast.
Our recent episode on the Interventions Testing Program's recent tests on various longevity interventions sparked some interesting debate on X. City of Hope National Medical Center's Alfred E. Mann Family Foundation...
2024-07-0441 min
The Optispan Podcast with Matt KaeberleinScientists Discuss Longevity Interventions & Optimisms | 45 - K-Lab Reunion
Subscribe to our channel: https://www.youtube.com/@optispan
Related episode:
The Two New Highest Ranked Compounds For Lifespan Extension According to the ITP: https://youtu.be/b4VaXqeli8c
Matt, who ran the Kaeberlein lab at the University of Washington from 2006 to 2023, rounded up several former lab members for a chat at the recent 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin. The group included assistant and tenured professors at various institutions around the United States, startup founders, and prospective PhD students with geroscience research interests that span the microbiome, mitochondrial dysfunction, frailty, metabolism...
2024-07-0247 min
The Optispan Podcast with Matt KaeberleinWhy Drinking a Banana Smoothie IS the Same as Eating a Banana | 44 - Longevity this Week #8
Subscribe to our channel: https://www.youtube.com/@optispan
Should you add bananas to your smoothies?
No, according to someone on TikTok who posted a viral video suggesting that our smoothies should be banana-free. On the basis of a 2023 scientific journal article, this TikTok user asserted that bananas destroy the beneficial polyphenols found in other fruits and vegetables that might be in your smoothie.
As is often the case with science, there's more to this story than the punchline. In this episode, Matt puts a magnifying glass to the 2023 journal article to figure out what the study actually showed...
2024-06-2732 min
The Optispan Podcast with Matt KaeberleinHow Pregnancy Affects Aging, New Model Organisms for Aging Research, HRT | 43 - Berenice Benayoun
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
These 14 Medications are linked to lower death rates in humans: https://youtu.be/Ju1p_L-2Bq4
Is This The Best Time to Exercise?: https://youtu.be/59SFzLEy6Jg
Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in the longevity field.
One of these was Berenice Benayoun, an Associate Professor (recently tenured!) of Gerontology, Biological Sciences, Biochemistry, and Molecular Medicine at the University of Southern California Leonard Davis School of Gerontology. Berenice...
2024-06-2545 min
The Optispan Podcast with Matt KaeberleinSolving the "Lack" of Anti-aging Discovery & Ranking Current Interventions | 42 - Mark McCormick
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4
Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in the longevity field.
One of these was Mark McCormick, an Assistant Professor at the University of New Mexico (UNM) Department of Biochemistry and Molecular Biology. At UNM, Mark runs a lab that investigates age-delaying drug targets, develops machine learning tools for studying aging, and identifies conserved aging mechanisms and...
2024-06-1849 min
The Optispan Podcast with Matt KaeberleinThe UNEXPECTED Ozempic Weight Loss Body Scan Results (DEXA) | 41 - HSM #8
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI
We brought George Sutphin back on the podcast to bare his soul—or at least his DEXA scan and VO2 max test results.
A DEXA (dual-energy X-ray absorptiometry) scan is an advanced imaging procedure for measuring bone density and composition. DEXA scans utilize two different energy levels of low-dose X-ray beams—one absorbed mostly by soft tissue, and the other absorbed mainly by bone—to differentiate between bone, fat, and lean tissue...
2024-06-1332 min
The Optispan Podcast with Matt KaeberleinThe Two New Highest Ranked Compounds For Lifespan Extension According to the ITP | 40 - LTW #7
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
These 14 Medications are linked to lower death rates in humans: https://youtu.be/Ju1p_L-2Bq4
DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw
How do scientists decide which interventions are worth testing in humans for potential health- and/or lifespan benefits?
One way to start is to examine how interventions perform in model organisms such as mice. The Interventions Testing Program (ITP), a federally-funded initiative that began in 2002, tests drugs that may delay mouse aging, with the hope of eventually identifying new...
2024-06-1143 min
The Optispan Podcast with Matt KaeberleinSupplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN | 39 - George Sutphin
Subscribe to our channel: https://www.youtube.com/@optispan
Check out the Sutphin Lab: https://sutphinlab.org/
Related episodes:
Uncovering New Longevity Research DISCOVERIES: The Power of 3HAA Revealed: https://youtu.be/CFVQUSVJmIk
People are GETTING THIS WRONG about Supplements & My Supplement List: https://youtu.be/_UXk_ynCNUs
DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw
Does this Dog Supplement Really Work to REVERSE AGE? (PART 1): https://youtu.be/-ujIfZXGbDA
George Sutphin is back! So many of you enjoyed Matt's interview with him back in March 2024 about 3HAA and NAD+ that we decided to bring...
2024-06-061h 04
The Optispan Podcast with Matt KaeberleinAnswering Your Questions on Longevity | 37 - Ask Matt Anything #4
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw
Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk
Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4
We've hit 6,000 subscribers!
To celebrate this milestone and to thank you for your support, we've created an Ask Matt Anything (AMA) episode out of questions that you left on our previous podcast episodes. You guys ask great questions—we really enjoy thinking about the points you raise and gaining a...
2024-05-301h 05
The Optispan Podcast with Matt KaeberleinIs This The Best Time to Work Out? | 36 - Longevity This Week #6
Subscribe to our channel: https://www.youtube.com/@optispan
In this episode, we discuss three findings that have made the rounds in the geroscience and healthspan spaces in recent months. They relate to three universally-relevant topics: pregnancy, exercise, and diet.
The first study suggested that women who have been pregnant at least once age faster than women who had never been pregnant, controlling for social, environmental, and genetic variation and measuring aging rate via six epigenetic clocks.
The second study found a connection between workout timing and cardiovascular disease, microvascular disease, and all-cause mortality risk in adults with obesity...
2024-05-2855 min
The Optispan Podcast with Matt KaeberleinThe Surprising Way Body Size Relates to Lifespan | 35 - Longevity Science #7
Subscribe to our channel: https://www.youtube.com/@optispan
Is bigger always better?
It depends. Throughout the human lifespan, body size plays an important role in determining health outcomes and quality of life. It's not just about body mass index, fat distribution, weight, or muscle mass: there also exists a relationship between body size and longevity across multiple species, including humans. On average, larger species seem to live longer and age more slowly—think about the fact that dogs age about seven times faster than do humans, who are both heavier and taller than dogs. But within species, that re...
2024-05-2342 min
The Optispan Podcast with Matt KaeberleinDON'T Take Resveratrol Until You Watch This Video | 34 - Healthspan Medicine #8Subscribe to our channel: https://www.youtube.com/@optispan
Resveratrol is a naturally occurring polyphenolic compound found in various plants, including in the skins of grapes, blueberries, raspberries, mulberries, and peanuts. Its association with red wine has contributed to the illusion of the "French Paradox": the observation that French people have a relatively low incidence of heart disease despite a diet rich in saturated fats. If you were alive in the 2000s, you may remember cheering at the news that drinking red wine would protect your heart and help you live longer.
Unfortunately, this claim is not true. Matt...
2024-05-211h 07
The Optispan Podcast with Matt KaeberleinHow He TRANSFORMED His Health by Taking Accountability. | 33 - Healthspan Journey #1
Subscribe to our channel: https://www.youtube.com/@optispan
The journey towards prioritizing one's healthspan can be a circuitous path full of triumphs, setbacks and lessons. Challenges arise and old habits rear their ugly heads. Unforeseen obstacles test our resolve. The road is rarely linear and often leads us to unexpected places.
In this episode, Matt chats with former Microsoft Chief Technology Officer and one of our first Optispan Trailblazers Stuart McKee about Stuart's early forays into drugs, smoking, and alcohol consumption, how he stepped off the train to get his health (and life) in order, and how the...
2024-05-161h 40
The Optispan Podcast with Matt KaeberleinComparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS | 31 - R-Files #5
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
The R-Files episode 1: https://youtu.be/czx_-DqnnrQ
The R-Files episode 2: https://youtu.be/EgIy0ghrDmo
The R-Files episode 3: https://youtu.be/jLV5nOenD-g
The R-Files episode 4: https://youtu.be/6AjKOe-yZeM
Matt Kaeberlein's ALLERGIC REACTION to Medication While on Rapamycin: https://youtu.be/6vIVj4SaBx4
Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko
The Importance of Body Composition & Ways YOU can measure it: https://youtu.be/gM3aYTMsqNI
The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally...
2024-05-0923 min
The Optispan Podcast with Matt KaeberleinReversing Biological Age: Have we finally found the answer?? | 30 - LTW #5
Subscribe to our channel: https://www.youtube.com/@optispan
Matt recently exchanged a lively correspondence about biological age with Harold Katcher, cofounder of a stealth biotechnology company and inventor of E5. E5 is a compound consisting of the purified exosome fraction of blood from young piglets—in other words, young pig blood. Harold recently co-published a paper suggesting that injecting this young pig blood into rats made rats younger on several biological aging measures, including inflammatory markers and epigenetic aging signatures. Indeed, Harold has injected E5 into his own right hand and presented differences in the appearance of his ri...
2024-05-0751 min
The Optispan Podcast with Matt KaeberleinAI vs Aging: Why Wormbot-AI is the secret weapon against disease | 29 - Mitchell Lee
Subscribe to our channel: https://www.youtube.com/@optispan
Support the Longevity Million Molecule Challenge: https://orabiomedical.com/shop/
No single discipline or approach holds the key to making big strides in the longevity field. Human aging is incredibly complex, and we're going to need multiple shots on goal in our pursuit of human life- and healthspan extension. At the Optispan Podcast, we're always excited to learn about the various angles researchers and founders are taking to advance our understanding of longevity and get impactful therapeutics that will transform human health into the clinic.
In this episode, Ora Biomedical...
2024-05-021h 25
The Optispan Podcast with Matt KaeberleinAging Expert Explains How Healthcare got it ALL WRONG. | 28 - HSM #6
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes: https://youtu.be/YhzgYaY7wto
In April 2024, Matt delivered a presentation at a two-day congressional briefing on longevity science hosted at Washington, D.C.'s Mayflower Hotel by the Alliance for Longevity Initiatives (A4LI). Attendees included former Speaker of the House Newt Gingrich, Republican Congressman Gus Bilirakis, and Democratic Congressman Paul Tonko. We have decided to include Matt's presentation on our channel because we believe it delivers a valuable message.
Healthcare has historically taken a piecemeal approach to diseases, addressing ailments in isolation. While this method has...
2024-04-3029 min
The Optispan Podcast with Matt KaeberleinInside this Non-profit's AMAZING Strategy to Fight Aging | 27 - Dylan Livingston
Subscribe to our channel: https://www.youtube.com/@optispan
We talk a lot about the science of longevity and healthspan on the Optispan podcast—how DEXA scans work, what an optimal rapamycin dose might look like, how the intersection of optogenetics and mitochondria are helping us understand biological aging, what supplements one might consider taking and why.
But the longevity field runs on way more than just science. It takes a village—a community of researchers, engineers, entrepreneurs, investors, regulators, and beyond who believe in the value of tackling the biology of aging as a crucial strategy for extending heal...
2024-04-2524 min
The Optispan Podcast with Matt KaeberleinGuess his body fat percentage | #26 - Healthspan Medicine #5
Subscribe to our channel: https://www.youtube.com/@optispan
Related videos:
The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI
A DEXA (dual-energy X-ray absorptiometry) scan is an advanced imaging procedure for measuring bone density and composition. DEXA scans utilize two different energy levels of low-dose X-ray beams—one absorbed mostly by soft tissue, and the other absorbed mainly by bone—to differentiate between bone, fat, and lean tissue. In so doing, they provide noninvasive and detailed information about bone health, risk of osteoporosis or fractures, and body composition. While medical prac...
2024-04-2336 min
The Optispan Podcast with Matt KaeberleinDoctors overlook how significantly this impacts your health. | 24 - HSM #4Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
The Importance of Body Composition & Ways YOU can measure it | 21 - HSM #3: https://youtu.be/gM3aYTMsqNI
We talk a lot about making a shift from reactive disease care—a 20th century healthcare mindset—to preventative and proactive health measures designed to optimize longevity and healthspan before disease sets in. Rather than waiting for chronic conditions to manifest and treating their symptoms post hoc, we encourage investing resources in preemptive care and empowering individuals to act as partners with healthcare providers in their own wellbeing.
Preventative medicine can feel...
2024-04-1628 min
The Optispan Podcast with Matt KaeberleinThese 14 Medications are linked to lower death rates in humans | 23 - Longevity this Week #4
Subscribe to our channel: https://www.youtube.com/@optispan
Related episodes:
People are GETTING THIS WRONG about Supplements & My Supplement List | 17 - Healthspan Medicine #2: https://youtu.be/_UXk_ynCNUs
Transforming Our Understanding of Healthcare Through Geroscience | 11 - LS #4: https://youtu.be/LCPvF-SlZIU
We typically think of prescription drugs as targeted treatments designed to address the underlying mechanisms and biochemical pathways associated with specific diseases or conditions. For example, healthcare providers commonly prescribe statins that lower cholesterol levels and reduce cardiovascular disease risk by inhibiting the enzyme involved in cholesterol synthesis. Similarly, doctors might prescribe antibiotics to target bacterial infections...
2024-04-1251 min
The Optispan Podcast with Matt Kaeberlein“Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: | 22 - Natalia MitinSubscribe to our channel: https://www.youtube.com/@optispan
Senescent cells, cells that cease to divide and proliferate while remaining metabolically active, are a complex and intriguing aspect of biological aging. They serve as both a protective mechanism against cancer, preventing damaged cells from uncontrollable replication, as well as a contributor to tissue dysfunction and age-related pathologies such as cardiovascular disease, neurodegenerative disorders, and diabetes. The precise mechanisms that underlie senescence and its contributions to the aging process remain areas of ongoing investigation and debate.
In this episode, Matt chats with Sapere Bio co-founder and CEO Natalia Mitin about...
2024-04-101h 00
The Optispan Podcast with Matt KaeberleinAnswering Your Questions on Rapamycin: Optimal doses, tests, & stacks | 20 - AMA #3Subscribe to our channel: https://www.youtube.com/@optispan
The R-Files episode 1: https://youtu.be/czx_-DqnnrQ
The R-Files episode 2: https://youtu.be/EgIy0ghrDmo
The R-Files episode 3: https://youtu.be/jLV5nOenD-g
The R-Files episode 4: https://youtu.be/6AjKOe-yZeM
You asked, we listened. Ever since the February 2024 launch of our series "The R-Files", a series of episodes about all things rapamycin, we've received a ton of questions about this compound and how it works in the context of aging and longevity. We went through every comment you left on Youtube, Twitter, and LinkedIn to compile a list of...
2024-04-0139 min
The Optispan Podcast with Matt KaeberleinDoes this Dog Supplement Really Work to REVERSE AGE? (PART 2) | 19 - Longevity This Week #3 (2/2)Subscribe to our channel: https://www.youtube.com/@optispan
Part I: https://youtu.be/-ujIfZXGbDA
At the Optispan Podcast, we aim to help you become your own detective of research in the geroscience field and beyond. Critical thinking is our compass. We want to help you dig into every aspect of a study: are the methods they used solid? Was the sample size big enough? Did they crunch the numbers right? What's the most reasonable interpretation of the data? Might a conflict of interest skew the results?
In Part II of a two-part series about a recent study of...
2024-03-2935 min
The Optispan Podcast with Matt KaeberleinDoes this Dog Supplement Really Work to REVERSE AGE? | 19 - Longevity This Week #3Subscribe to our channel: https://www.youtube.com/@optispan
When drug development companies promote their products, they understandably highlight the benefits and potential relief they offer. While these advertisements can make the products seem like game-changers for health issues, it's important not to swallow the marketing spiel whole. Question it, test it, poke and prod it to see if it holds up under scrutiny. Take the time to research the drug independently and examine what the press release or advertisement claims. Look for unbiased sources like medical journals, regulatory agencies, or reputable health websites that might provide a more...
2024-03-2723 min
The Optispan Podcast with Matt KaeberleinRapamycin's SURPRISING Effects on Aged IMMUNE SYSTEMS | 18 - RF #4
Subscribe to our channel: https://www.youtube.com/@optispan
The R-Files episode 1: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1675s
The R-Files episode 2: https://www.youtube.com/watch?v=EgIy0ghrDmo&t=140s
The R-Files episode 3: https://www.youtube.com/watch?v=jLV5nOenD-g&feature=youtu.be
The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered...
2024-03-2541 min
The Optispan Podcast with Matt KaeberleinPeople are GETTING THIS WRONG about Supplements & My Supplement List | 17 - Healthspan Medicine #2Subscribe to our channel: https://www.youtube.com/@optispan
As a longevity scientist, Matt often receives questions about what supplements he takes—so we decided to make an episode where Matt discusses his supplements protocol.
This episode isn't meant to provide a playbook for you to follow. We want to emphasize the importance of approaching supplements with discernment and an understanding that they are not a substitute for wholesome nutrition and other healthy lifestyle practices. The allure of supplements is understandable: they promise us vitality, strength, and longevity in a convenient capsule. But their indiscriminate consumption can be risky. Bl...
2024-03-2030 min
The Optispan Podcast with Matt KaeberleinCAR T Cells: The Ultimate Anti-Aging Solution? | 16 - Longevity This Week #2Subscribe to our channel: https://www.youtube.com/@optispan
While scientific papers are generally considered trustworthy sources of information, it's important to approach them with a critical mindset and to avoid blindly accepting their claims. The peer-review process, which helps ensure high research quality, is not foolproof. Errors or biases can slip through the cracks. In reading a paper, we should independently evaluate the evidence, scrutinize the methodology, and reflect on alternative interpretations of the data. Considering the influence of funding sources, conflicts of interest, and the potential for selective reporting can also help in maintaining a healthy skepticism...
2024-03-1951 min
The Optispan Podcast with Matt KaeberleinCurrent Healthcare ISN'T CUTTING IT: How Optispan is REVOLUTIONIZING it |15 - Healthcare Medicine #1Subscribe to our channel: https://www.youtube.com/@optispan
At its best, healthcare isn't just about extending lifespan—it's also about enhancing the vitality of our years. Over the last century, the healthcare system has made enormous strides in keeping sick people alive. The next step is to use proactive, preventative healthcare to stop them from getting sick at all. The Lost Decade—the 10 or so years that many people spend suffering from poor health and/or disability in older age—doesn't have to be a given.
In this episode, Matt discusses why he left academia to help start a heal...
2024-03-1321 min
The Optispan Podcast with Matt KaeberleinLongevity Science 2024: New Insights on "The Hallmarks of Aging" & What They Mean | 14 - LS #5Subscribe to our channel: https://www.youtube.com/@optispan
Over a decade ago, five researchers published a paper proposing the Hallmarks of Aging paradigm: a set of cellular and molecular processes that underlie the aging process in different organisms. These hallmarks encompass a range of interconnected pathways, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient signaling, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Together, the hallmarks contribute to the gradual decline in physiological function and increased susceptibility to age-related diseases that occurs with age, and provide...
2024-03-1144 min
The Optispan Podcast with Matt KaeberleinMatt Kaeberlein's ALLERGIC REACTION to Medication While on Longevity Drug Rapamycin | 13
Subscribe to our channel: https://www.youtube.com/@optispan
Everyone has different reactions to medications—you might experience indigestion after taking a new drug, while someone else might feel nothing at all. In this episode, Matt describes his recent experience developing a bacterial infection while taking a course of antibiotics and discusses the importance of being aware of and prepared for any medication-induced allergic reactions that may occur.
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, no...
2024-03-0811 min
The Optispan Podcast with Matt KaeberleinUncovering New Longevity Research DISCOVERIES: The Power of 3HAA Revealed | 12 - George Sutphin
Subscribe to our channel: https://www.youtube.com/@optispan
The Sutphin Lab: https://sutphinlab.org/
University of Arizona Assistant Professor of Molecular and Cellular Biology George Sutphin runs a lab that investigates genetic determinants of longevity, the effects of kynurenine-based interventions on lifespan, and environmental regulators of the aging process. George, who was an aerospace engineer before he discovered the promise of geroscience, completed his PhD at the University of Washington and worked as a postdoctoral associate at the Jackson Laboratory prior to his current faculty position. He currently serves as Chairperson of the American Aging Association.
We sat...
2024-03-062h 10
The Optispan Podcast with Matt KaeberleinTransforming Our Understanding of Healthcare Through Geroscience | 11 - LS#4Subscribe to our channel: https://www.youtube.com/@optispan
Everything we talk about on The Optispan Podcast has geroscience at its root, so we decided to make an episode about it. Geroscience is the study of the mechanisms connecting biological aging with disease and disability. The term first appeared in the scientific literature around 2008, and its use has steadily increased since as researchers have discovered more about the aging process and its impact on our health. While it's clear that aging biology is at the root of the diseases and disabilities that most people get sick with and die...
2024-03-0422 min
The Optispan Podcast with Matt KaeberleinWhat a 93-Year-Old Rowing Champion Can Teach Us About Aging Well | 10 - Longevity this Week #1Subscribe to our channel: https://www.youtube.com/@optispan
Defining "healthspan" & its role in living longer: https://www.youtube.com/watch?v=cI6CNFeBl88
Longevity This Week is a series of episodes discussing new findings or articles relevant to geroscience, longevity, and healthspan that may have popped up in the news.
This week we're featuring Richard Morgan, a 93-year-old rowing champion whom the Washington Post recently described as being "as fit as a 40-year-old". We talk about Richard's diet, exercise routine, and other aspects of his lifestyle that may have led to his enviable state in older age. We...
2024-03-0129 min
The Optispan Podcast with Matt KaeberleinBiological Age & what it REALLY means | 9 - Longevity Science #3
Subscribe to our channel: https://www.youtube.com/@optispan
Understanding Aging & Disease and How They're Related: https://www.youtube.com/watch?v=94_Rqe2m1C0&feature=youtu.be
Biological age—that is, how old your cells and tissues are based on physiological function—is a multifaceted and intricate concept that transcends numerical representation. Unlike chronological age, which refers simply to the number of years you have been alive, the concept of biological age delves into the dynamic interplay between physiological processes, genetic predispositions, and environmental influences that collectively shape an individual's health trajectory. Geroscientists are currently studying the biological mech...
2024-02-2823 min
The Optispan Podcast with Matt KaeberleinRapamycin's possible SIDE EFFECTS & BENEFITS | 8 - RF#3
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that...
2024-02-2633 min
The Optispan Podcast with Matt KaeberleinDentist Reveals Exciting Research Findings Involving Rapamycin on Oral Health | 5 - Jon An, DDS, PhD
Matt and guest Jonathan An, Assistant Professor of Oral Health Sciences at the University of Washington School of Dentistry, discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed...
2024-02-211h 13
The Optispan Podcast with Matt KaeberleinOff-Label Rapamycin Experiences & Doses | 7 - RF#2
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that...
2024-02-2115 min
The Optispan Podcast with Matt KaeberleinRapamycin's Impact on Oral Health & its Relationship to Aging (Part 2)Matt and guest Jonathan An discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode.
EP 1:
Jon's career choices + how he realised aging was important
Aging and oral health/potential relationships between periodontal disease and diseases of aging
EP 2 (February 14th):
The divide between oral health and the rest of the body
Tips for maintaining oral health/How you know you're doing well
EP 3 (February 21st):
Longevity interventions...
2024-02-1417 min
The Optispan Podcast with Matt KaeberleinAn introduction to the study of RAPAMYCIN | 6 - R-Files w/ Matt KaeberleinThe R-files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, from yeast to mice. Matt, who has spend a significant part of his career studying rapamycin, will discuss rapamycin and its relevance to longevity...
2024-02-1232 min
The Optispan Podcast with Matt KaeberleinRapamycin's Impact on Oral Health & its Relationship to Aging | 5 - Jonathan An, DDS, PhDMatt and guest Jonathan An discuss oral health and its relationship to aging, including published studies involving rapamycin effects on oral health. This is a 3-part episode.
EP 1:
Jon's career choices + how he realised aging was important
Aging and oral health/potential relationships between periodontal disease and diseases of aging
EP 2 (February 14th):
The divide between oral health and the rest of the body
Tips for maintaining oral health/How you know you're doing well
EP 3 (February 21st):
Longevity interventions...
2024-02-0732 min
The Optispan Podcast with Matt KaeberleinLongevity Expert Matt Kaeberlein Exposes Common Myths Circulating the Media | 4 - Nick Arapis
Optispan CEO Matt Kaeberlein discusses common assumptions about longevity and healthspan.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not...
2024-02-0535 min
The Optispan Podcast with Matt KaeberleinLongevity Expert Sheds Light on common MISCONCEPTIONS for People's' Health | 3 - Nick ArapisOptispan CEO Matt Kaeberlein discusses common assumptions about longevity and healthspan.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute...
2024-02-0137 min
The Optispan Podcast with Matt KaeberleinFlaws in the Healthcare System, Preventative Medicine, and Next-Gen Healthcare (Part 3)
Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/
Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant...
2024-02-0115 min
The Optispan Podcast with Matt KaeberleinFlaws in the Healthcare System, Preventative Medicine, and Next-Gen Healthcare (Part 2)Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/
Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be...
2024-02-0140 min
The Optispan Podcast with Matt KaeberleinFlaws in the Healthcare System, Preventative Medicine, and Next-Gen Healthcare | 2 - Kevin White, MD
Check out Prime Health Associates for personalized healthcare solutions: https://www.primehealthassociates.com/
Optispan CEO Matt Kaeberlein chats with Prime Health Associates Physician Kevin White about making the transition from research to building a company, moving towards preventative medicine in the 21st century, incorporating new discoveries into medical practice, and more.
Watch our episodes on video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be...
2024-02-0120 min
The Optispan Podcast with Matt KaeberleinQ&A with Scientist Matt Kaeberlein about Longevity and Living Longer | The Optispan Podcast EP 1Optispan CEO Matt Kaeberlein takes questions about healthy aging.
Watch our episodes with video: https://www.youtube.com/channel/UCSna7385c3Xg_4Too92NKMw
Producer: Tara Mei
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan YouTube channel is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or...
2024-02-0133 min