Shows
The Hunter Williams PodcastP21 | The Brain Peptide Nobody Is Talking AboutJoin My Private Group: https://theaxioncollective.manus.space/Email List: https://huntershealthhacks.beehiiv.com/Get My Book On Amazon: https://a.co/d/avbaV48DownloadThe Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/In this episode, I finally dive deep into a peptide I’ve wanted to talk about for a long time: P21.P21 is what I would call a true brain health peptide. It’s not a nootropic in the classic “stimulant” sense, and it’s definitely not a limitless-pill type compound. Instead, it works upstream, supporting the brain by upregulating BDNF, enhancing neurogenesis, improving synaptic connectivity, and reducing neuroinflammation.I first heard about P21 years ago through parents of neurodivergent children who w
2026-01-2727 min
Glaucoma, Vision & Longevity: Supplements & ScienceQuercetin and Fisetin as Candidate Senolytics in Optic Nerve AgingThis audio article is from VisualFieldTest.com.Read the full article here: https://visualfieldtest.com/en/quercetin-and-fisetin-as-candidate-senolytics-in-optic-nerve-agingTest your visual field online: https://visualfieldtest.comExcerpt:Aging, Senescence, and GlaucomaGlaucoma is a leading cause of blindness and its risk rises with age. In aged eyes, cells can enter a senescent state – they stop dividing but stay alive – and release harmful signals called the senescence-associated secretory phenotype (SASP). Senescent cells in the eye can worsen disease. For example, aged trabecular meshwork cells (the filter in front of the eye) become stiff and clog...
2025-12-1410 min
The Print FilesSeptember was a Big Month In PrintIn this episode of The Print Files: A Big Month in Print, Lindy Hughson and Jan Arreza analyse the major news and trends shaping the Australasian print industry in September.We begin this month’s review with major distribution moves, as EFI appoints Currie Group as its exclusive Sign & Display distributor across Australia and New Zealand, and Canon partners with Rodden Graphics to expand into packaging and labels via Edale flexo systems. We also cover Rawson’s acquisition of IntoPrint following its Megacolour purchase, CS Graphics’ management buyout of Aldus Graphics’ distribution arm, and the US$80 million acquisit...
2025-10-0714 min
梶原塾/宅建チャンネルPCR7M19_完全合格マニュアル_P21_梶原塾宅建ポッドキャストPCR7M19_完全合格マニュアル_P21_梶原塾宅建ポッドキャスト
梶原塾の講座に興味があるけど、始めるのに迷っている方におすすめです。
テキスト・問題集についてはすべてWeb上のPDFをダウンロードしてご利用ください。
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https://kajiwarajuku.com/takken/01.html
#宅建
#宅建合格
#資格試験
#宅建士
#資格
2025-07-2001 min
RadOnc Smart ReviewRadBio E36: Cell Cycle Gate keepers: p53/p21 & Rb/E2FWelcome back to Rad Onc Smart Review! This is Episode 36: Cell Cycle Gatekeepers: p53/p21 & Rb/E2F. In our previous episodes, we've delved into how cells sense and repair DNA damage. Today, we're going to focus on two critical molecular pathways that act as gatekeepers of the cell cycle, ensuring that cells don't progress with damaged DNA, which could lead to mutations and cancer. We'll explore how the tumor suppressor p53 is activated by DNA damage, its regulation by MDM2, and how p53 then induces p21 to halt the cell cycle in G1. We'll also dissect the Rb/E2...
2025-05-3020 min
Mind and Muscle - dein Fitness-Podcast#12: Muscles, Mama-Life & Meal Prep – Rebeccas Weg auf die BühneSchwanger trainieren? Neben Job, Kids & Wettkampfdiät noch Zeit fürs eigene Training finden? Willkommen in Rebecca Werners Welt! Seit 2017 träumt sie davon, auf der Bodybuilding-Bühne zu stehen – jetzt geht’s endlich los: Wettkämpfe in der Schweiz & Portugal, zusammen mit ihrem Mann Roman. Doch der Weg dahin war alles andere als ein gerader Sprint. Wie sie durch zwei Schwangerschaften trainiert hat, welche Supplements sie genommen hat und wie sie es schafft, zwischen Job, Meal Prep und Kindersorgen trotzdem noch 100% im Sport zu geben – das hört ihr in dieser Folge. 🎧 Jetzt reinhören, inspirieren lassen und Vollg
2025-03-3048 min
Asrar Al Quran - أسرار القرآنبودكاست أسرار القرآن- سورة البقرة - ص21- آيات 135 :141| Asrar Al Quran Podcast- Surat Al-Baqarah-P21بودكاست أسرار القرآن- سورة البقرة - ص21- آيات 135 :141| Asrar Al Quran Podcast- Surat Al-Baqarah-P21
2025-03-2114 min
亞瑟邏輯學堂EP-P21-邏輯推理遊戲：誰是檜木盜伐者？留言告訴我你對這一集的想法： https://open.firstory.me/user/cluwlhkv70k2a01ujea7nanlc/comments EP-P21-邏輯推理遊戲：誰是檜木盜伐者？ 本集邏輯推理遊戲「誰是檜木盜伐者？」，題目如下所述： 在一片寧靜的森林深處，珍貴的檜木屹立已久，宛如森林的守護者。然而，一天清晨，林中的巡山員驚訝地發現，一棵古老的檜木竟然被人偷砍，只留下斑斑鋸痕。這起盜伐事件震動社會，所有人都希望找出真兇。 經過調查，森林警察鎖定了三名嫌疑人：張勇、李剛和王明，他們當天都曾在山林附近出現。三人被森林警察約談，並接受偵訊。他們三人都知道隨是檜木盜伐者，三人各自說了兩句話，用來迷惑森林警察： 張勇堅稱：「檜木不是我砍的，也不是李剛砍的。」 李剛反駁：「檜木不是我砍的，也不是王明砍的。」 王明則表示：「檜木不是我砍的，我也不知道是誰砍的。」 三人的供詞使案情更加撲朔迷離，但森林警察知道:檜木盜伐者僅有一人，且三人的供詞中，有一句為真，另一句為一假。 森林警察如何由這三人的供詞中，破解其中的矛盾，發現隱藏在真假供詞中的真相，確認真正的檜木盜伐者？ 答案及詳細解說，將於「亞瑟邏輯學堂」FB粉絲專頁公開。請點選說明或逐字稿中連結觀看。 解說 EP-P21-邏輯推理遊戲：誰是檜木盜伐者？ https://www.facebook.com/share/p/1L4ibNxrNw/ 「亞瑟邏輯學堂」FB粉絲專頁 https://www.facebook.com/arthurlogic 我們的節目內容在各大Podcast、YouTube同步上架，請搜尋「亞瑟邏輯學堂」。謝謝收聽！歡迎下次再來到「亞瑟邏輯學堂」。 Mail：artchen11@mail.com Powered by Firstory Hosting
2025-03-2102 minMind and Muscle - dein Fitness-Podcast#11: Zwischen Himmel und Hanteln – Tim Binder im TalkWie lebt man den Bodybuilding-Lifestyle, wenn der Beruf einen ständig um die Welt schickt? Angelina spricht mit Tim Binder – Maître de Cabine bei Swiss und ambitionierter Bodybuilder auf dem Weg zur ProCard. Sein Alltag? Reisen über Kontinente, Jetlag und trotzdem volle Disziplin für Training, Ernährung und Wettkampfvorbereitung. Wie bringt er Job und Bodybuilding unter einen Hut? Tim erzählt weiter, wie Fussball, Cristiano Ronaldo und Mike Sommerfeld seine Leidenschaft fürs Bodybuilding geprägt haben – und warum Mindset der Schlüssel zu Höchstleistung ist. Nicht nur im Gym, sondern im ganzen Leben. Eine Folge voller Inspira...
2025-03-091h 09Mind and Muscle - dein Fitness-Podcast#10: Love & Lifting – Gemeinsam auf die WettkampfbühnePassend zum Valentinstag gibt es eine besondere Episode des Mind & Muscle Fitness-Podcasts! Angelina hat das Bodybuilding-Powerpaar Svenja Fux & Damian Schaller aus dem Wallis zu Gast. Svenja bestritt 2024 ihre erste Wettkampfsaison in der Bikini-Klasse, während Damian, ein erfahrener Men’s Physique-Athlet, eine weitere Saison absolvierte – zum ersten Mal gemeinsam mit seiner Partnerin. Was passiert, wenn Training, Disziplin und Wettkampfdruck auf Liebe treffen? Wie meistert ein Paar den Weg zur Bühne – gemeinsam, aber doch getrennt? Ein ehrlicher, inspirierender Talk über Leidenschaft, Entbehrungen und die Magie gemeinsamer Erfolge – mit exklusiven Einblicken für alle Fitness- und Bodybuilding-Fans! 🎧 Jetzt reinhören & mitfiebern!
2025-02-1459 minMind and Muscle - dein Fitness-Podcast#9: Prep-Talk mit Pro Figure Athletin Kathrin PlösserIn dieser Episode des Mind & Muscle Podcasts trifft Host Angelina auf unsere Natural Bodybuilding Athletin Kathrin Plösser. Gleich in ihrer ersten Saison holte sie sich bei der WNBF die Pro Card in der Figure-Klasse. Jetzt liegt ihr Fokus voll auf ihrer Herzensklasse: Women’s Physique. Kathrin teilt ehrliche Einblicke in ihre erste Prep, spricht über mentale und körperliche Herausforderungen wie Binge Eating und Verletzungen und verrät, wie sie es schafft, in mehreren Klassen gleichzeitig auf der Bühne zu glänzen. Diese Episode steckt voller Mehrwert für alle, die Wettkampfluft schnuppern wollen oder einfach mal hinter di...
2025-01-2351 minMind and Muscle - dein Fitness-Podcast#8: Follow your dreams - Roman Werner stellte alles auf den Kopf!Sucht, Wendepunkt, Bodybuilding – In dieser Folge des Mind & Muscle Fitness-Podcasts zeigt uns unser Ambassador Roman Werner, wie er sein Leben mit einem radikalen Shift auf ein neues Level gebracht hat. Bodybuilding war sein Anker, der ihm half, der Drogensucht zu entkommen und einen neuen Weg einzuschlagen. Heute lebt er sein Motto «Follow your dreams» als Athlet, Ehemann und Vater von zwei kleinen Kids – mitten in der Wettkampfvorbereitung, zusammen mit seiner Frau Rebecca.
Was treibt ihn an? Wie rockt er Job, Training und Familienchaos? Und warum ist er überzeugt, dass jeder seine Träume erleben kann?
...
2024-12-2845 min
2024-12-2000 minMind and Muscle - dein Fitness-Podcast#7: 45 Wochen Diät, 100 % Power: Belinda Achermann bei den WNBF WorldsBelinda Achermann ist zurück auf der Bühne – und wie! Bei den WNBF World Championships startet sie dieses Mal in gleich mehreren Kategorien und zeigt, wie beeindruckend Natural Bodybuilding sein kann. Angelina spricht mit der P21 Club Ambassadorin über 45 Wochen Kaloriendefizit, mentale Stärke und wie sie Muskelmasse und Feminität perfekt vereint.
Was treibt Belinda an? Wie bleibt sie nach fast einem Jahr Wettkampfvorbereitung motiviert? Und was passiert, wenn sie von der Bühne kommt? Spoiler: Es hat was mit Cheat-Time zu tun!
Plus: Belindas genialer Pro-Tipp, mit dem du ab sofort mehr Reps sch...
2024-11-2457 minMind and Muscle - dein Fitness-Podcast#6: Zurück im Game: P21 Club reloaded!Der Mind & Muscle Fitness-Podcast ist zurück – und das mit neuem Drive! Wir tauchen ein in die neue P21 Club Ära und geben dir exklusive Einblicke und spannende Infos. Einschalten lohnt sich!
2024-11-0321 min
TechstinationPolydrops opens orders for most energy efficient RVTechstination, your destination for gadgets and gear. I’m Fred Fishkin. What is being called the world’s most energy efficient RV has launched. Polydrops has opened pre-orders for the P21…a travel trailer designed for off grid adventures with a 1300 watt solar array, thermal insulation, a heat pump for staying warm or cool….and a lightweight design making it towable by EVs…including the Tesla Model Y. Pricing starts at about 39 thousand dollars. Founder Kyunghyun Lew..
“The base model of the P21, it just basically has a bed and a couch inside and a table. But still we’re going to come w...
2024-09-0901 min
TechstinationTechstination Interview: Super efficient P21 RV from Polydrops now open to orderPolydrops super efficient P21 RV is officially open for pre-orders. Towable by EVs and more and solar powered. More? Co-founder Kyunghyun Lew chats with Techstination's Fred Fishkin.
2024-08-1315 min
Myleava - Rav Ron ChayaLa prière du matin pas-à-pas et dès le début ☕ Bien commencer la journée (P21)Comment devons-nous prier le matin ?
Quels sont les parties primordiales ?
Décryptage dans ces cours.
☕ Bien commencer la journée (P21)
🔖 Cours dédié pour la guérison rapide et complète de Yossef ben Victoria
🏁 Bénéficiez d'un reçu Cerfa en France et 46 en Israël
🚩 Soutenir la diffusion de la Torah avec le Rav Ron Chaya
Le défi de notre temps !
🤝 Dans cette période difficile et cruciale pour la délivrance finale, il faut augmenter la diffusion de la Torah avec le Rav Ron Chaya : Votre mérite ser...
2024-07-2909 min![Desde el sofá - Cine y TV [Audios]](https://static-2.ivoox.com/audios/7/f/e/8/7fe81d89d5b9315d722be4340435eb0a_XXL.jpg)
Desde el sofá - Cine y TV [Audios]Entrevista a David Pérez codirector del 1º Pucela Fantástica (PUFA)🗣️🎙️ Entrevista a David Pérez codirector del Pucela Fantástica (PUFA) de Valladolid.
📢 La 1ª edición del Pucela Fantástica (PUFA) 📽️😨👿🎭🎹 se celebra del 1 al 6 de julio en los Cines Broadway de Valladolid con 20 películas a competición, concurso de cortometrajes, proyecciones especiales y varias actividades paralelas.
ℹ️ Toda la info. en http://pufa.es/
▶️ Entrevista realizada en el P21 de #Festivaleros de junio parte 2 que puedes ver entero en el canal de YouTube de Mundoplus.tv (https://www.youtube.com/live/qXDB3kW1reY) o escuchar en el canal de iVoox del programa (https://www.ivoox.com/p21-festivaleros-junio-2024-parte-2-audios-mp3_rf_130933501_1.html).
#P...
2024-06-2937 min![Desde el sofá - Cine y TV [Audios]](https://static-2.ivoox.com/audios/1/f/9/a/1f9ab239a3e5442216aeb8e14ced0023_XXL.jpg)
Desde el sofá - Cine y TV [Audios]Entrevista a Antoine Leonetti director de la 29ª Mostra Fire!! de Barcelona🗣️🎙️ Entrevista a Antoine Leonetti director de la 29ª Mostra Fire!! de Barcelona.
📢 La 29ª edición de la Mostra Fire!! - Mostra de Cinema LGTBI de Barcelona 📽️🌈🔥🌸 llega al Institut Français del 6 al 16 de junio con más de 40 títulos de cine de calidad, reivindicativo y diverso.
ℹ️ Toda la info. en https://mostrafire.com
▶️ Entrevista realizada en el P21 de #Festivaleros de junio parte 1 que puedes ver entero en el canal de YouTube de Mundoplus.tv (https://www.youtube.com/watch?v=zvJlxTxo4og) o escuchar en el canal de iVoox del programa (https://www.ivoox.com/p21-festivaleros-junio-2024-parte-1-audios-mp3_rf_130049891_1.html).
#Mostr...
2024-06-0851 min
Mind and Muscle - dein Fitness-Podcast# 5: Alles für den Tag X?Jedes Meal zählt: Andrea Schärer, Tim Hemme und Thomas Kunz sind in ihren diesjährigen Wettkampfvorbereitungen. Zum ersten Mal ist unser SNBF Schweizermeister Noah Imesch im Podcast dabei. Zeit, Genetik, Progression, Disziplin, Trainingsjahre, Verzicht, Off-Season, mentale Stärke, Posing, Jury Feedback, Wettkampferfahrung, Kritik, Mut, Pro Card. Unsere Athleten philosophieren über den langen Weg, bis du am Tag X auf der Bühne stehst und deine Bestform präsentieren kannst. Alles für den Tag X oder ein Investment in dich selbst? Höre rein und entscheide selbst.
2024-05-1953 min
Tim Hatch LiveExodus 32: Who is LEADING Your Life?: P21 | Bible StudyExodus 32: Who is LEADING Your Life?: P21 | Bible Study by Tim Hatch
2024-05-1656 min
OncotargetTransfected SARS-CoV-2 Spike DNA Suppresses Cancer Cell Response to ChemotherapyBUFFALO, NY- May 6, 2024 – A new research paper was published in Oncotarget's Volume 15 on May 3, 2024, entitled, “Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure.”
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been d...
2024-05-0604 min
Aging-USCover Paper: Senescent Characteristics of Human Corneal Endothelial Cells Upon UV-A ExposureBUFFALO, NY- April 30, 2024 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.”
In this new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center investigated the senescent phenotypes of human corneal endoth...
2024-04-3004 min
Mind and Muscle - dein Fitness-Podcast#4 NPC 1UP EventGrosse Klasse, was unser neuer Ambassador Fabian Kälin gezeigt hat, er gewinnt den Overall in der Men’s Physique an der NPC Swiss Spring Show. Wird er sich auch auf der internationalen Bühne behaupten? War es für Gabriel Moreno die richtige Entscheidung die Prep abzubrechen und nicht am 1Up Event teilzunehmen? Warum reicht das Judge-Feedback «fantastic» für Rebecca Gloor nicht für den Sieg? Tim oder Fabian - wer würde im direkten Mens’ Physique Vergleich gewinnen? Wie fühlt sich Thom in seiner Prep nach dem Klassenwechsel Upgrade in die Men’s Physique? Antworten auf diese Frage...
2024-04-1450 min
Mind and Muscle - dein Fitness-Podcast#3: Prep & Pro CardBodybuilding boomt. Auf Social Media jagen viele dem perfekten Körper nach. Fitness-Neulinge finden, bisschen Stoff, trainieren und du siehst brutal aus! Aber halt, unsere Experten Tim Hemme, Gabriel Moreno, Thomas Kunz und Yannik Fasnacht widersprechen. In der neuen Folge diskutieren sie darüber, ab wann sich eine Sommer-Diät von einer Wettkampf-Prep unterscheidet und was die kritischen Erfolgsfaktoren in einer Wettkampf-Vorbereitung sind. Weiter sprechen sie darüber, wie sich eine Diät so nachhaltig und angenehm wie möglich gestalten lässt und was es bei verschiedenen Ernährungsformen zu beachten gibt. Ein weiteres grosses Ziel von Athleten: die Pro...
2024-03-241h 30
Aging-USPR55α-controlled PP2A Inhibits p16 Expression and Blocks Cellular Senescence InductionBUFFALO, NY- March 19, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.”
Cellular senescence is a permanent cell cycle arrest that can be triggered by both internal and external genotoxic stressors, such as telomere dysfunction and DNA damage. The execution of senescence is mainly by two pathways, p16/RB and p53/p21, which lead to CDK4/6 inhibition and RB activation to block cell cycle progression. While the regulation of p53/p21...
2024-03-1904 min
Mind and Muscle - dein Fitness-Podcast#2: Finde dein Wieso / Prep unserer Athleten / Arnold Classic RecapBodybuilding- Athleten wollen gewinnen. Aber geht es wirklich nur darum? Diese spannende Frage hat ein Podcast-Hörer gestellt und sie wird in dieser zweiten Podcast-Folge ausführlich besprochen. Über ihr ganz persönliches Wieso erzählen Andrea Schärer, Gabriel Moreno, Rebecca Gloor, Thomas Kunz, Tim Hemme und Yannik Fasnacht. 4 weeks out heisst es für Rebecca und Gabriel: wer mit Rückschlägen zu kämpfen hat und wer seine Prep mit links meistert? Höre rein. Und zu guter Letzt, also eigentlich zu Beginn, sprechen sie frei Schnauze über die Resultate der Arnold Classics 2024 und das bevorstehende Arnold Sport...
2024-03-101h 05Mind and Muscle - dein Fitness-Podcast#1: Get2know P21 Club / Fehler in der Prep / Arnold Classic PredictionAm Ende stehst du allein auf der Wettkampf-Bühne. Aber auf
dem Weg dorthin macht es im Team einfach viel mehr Spass: das ist der P21 Club, eine grosse Community. Lerne uns kennen, wir nehmen dich mit auf unsere Reise. In der ersten Podcast-Folge plaudern Thomas Kunz, Gabriel Moreno, Tim Hemme und Yannik Fasnacht über ihren Werdegang und ihre Leidenschaft für das
Bodybuilding. Hast du gewusst, dass wir einen Tischtennis-Profi im Team haben? Sie diskutieren unter anderem über die Vor- und Nachteile gleichzeitig Athlet und Coach zu sein, wann eine mehrjährige Off-Season Sinn macht, und sie offenbaren
ihre...
2024-02-251h 32
Peso Smart PH: Investing in the PhilippinesEPISODE #321: SGP - Synergy Grid & Development Phils., Inc. (Performance & Financials Review)Company Description of SGP (PSE Edge):
- Synergy Grid & Development Phils., Inc. (SGP) was originally incorporated on June 1, 1970 as Mankayan Minerals Development Company, Inc. On February 22, 1994, the Securities and Exchange Commission (SEC) approved the Company's change in corporate name to UEM Development Phils., lnc., and the change in primary purpose from engaging in mining activities to general construction and other allied businesses.
- On March 28, 2011, the SEC approved the change in corporate name to the present one, as well as the change in primary purpose to engage in power, energy, utilities, infrastructure...
2024-02-0215 min
Aging-USGenetic Profiles of Senescent Corneal and Conjunctival Epithelial Cells in HumansBUFFALO, NY- October 2, 2023 – A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 18, entitled, “Gene expression signatures of human senescent corneal and conjunctival epithelial cells.”
In this new study, researchers Koji Kitazawa, Akifumi Matsumoto, Kohsaku Numa, Yasufumi Tomioka, Zhixin A. Zhang, Yohei Yamashita, Chie Sotozono, Pierre-Yves Desprez, and Judith Campisi from the Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine and Lawrence Berkeley National Laboratory aimed to investigate the senescent phenotypes of human corneal and conjunctival epithelial cells.
“Here, we induc...
2023-10-0203 min
綺麗になるラジオ By HIMECLINICNo.63 PRP特集、なぜ老化するのかテキストは9月21日に行われた美容クリニックのラジオ番組の内容をまとめたものである。番組では美容クリニックの専門家を迎えて、肌の老化の理由とプラズマリッチプレートレット(PRP)療法について議論が行われた。専門家は紫外線被曝や糖化ストレスだけではなく、遺伝子レベルでの細胞のコピーミスが人の肌の老化の主な原因であると説明した。また、P16、P21、P53という3つの主要な遺伝子が正常に機能しなくなると、がん細胞の発生や早期の老化が起こり得ると議論した。さらに、食生活の中でアルデヒドが多く含まれる食品を過剰に摂取することも老化を早める原因になると指摘した。
紫外線と糖化ストレス以外に、遺伝子レベルでの細胞のコピーミスが肌の老化の主要な原因である専門家は紫外線被曝と糖化ストレスだけでは人の肌の老化を説明できないと指摘し、遺伝子レベルでの細胞のコピーミスこそが主要な原因であると説明した。年を取るにつれて、細胞を新しく作るのに用いられる遺伝子のコピーの質が低下し、若い頃と比べると誤った遺伝子を使って細胞が作られるようになる。この過程で、老化した細胞が増えてゆく。P16、P21、P53遺伝子の機能不全は、がんと早期老化の原因になりうるP16、P21、P53という3つの主要な遺伝子が正常に機能しなくなると、がん細胞が増殖したり、早期の老化が生じたりする。これらの遺伝子は細胞の増殖を制御する役割を担っており、機能が低下すると細胞のコントロールが失われ、がんや早期老化が起きやすくなる.
紫外線から肌を守るために、日焼け止めを使用すること。
糖化ストレスを避けるために、アルデヒドが多く含まれる食品の過剰な摂取を控えること。
定期的に皮膚科で肌のチェックを受けること。
遺伝子レベルでの細胞のコピーミスに起因する老化を遅らせるために、抗酸化物質を多く含む食事を心がけること。
2023-09-2114 min
P1 with Matt and TommyOur mid-season F1 Driver Ratings: P21 to P11We've averaged out all our F1-to-10 driver ratings for the first half of the season, and today we reveal who we've each got in P21 to P11.Join us tomorrow where we'll go through our top tens! You can grab our new merch here!Follow us on socials! You can find us on Twitter, Instagram, Twitch, YouTube and TikTok. Hosted on Acast. See acast.com/privacy for more information.
2023-08-1330 min
V RADIO by Huong NguyenP21- SỨC MẠNH CỦA TĨNH TÂM- Đi trông nước chảy, ngồi nhìn mây trôiP21- SỨC MẠNH CỦA TĨNH TÂM- Đi trông nước chảy, ngồi nhìn mây trôi
2023-07-2908 min
Aging-USSenescence and Senotherapies in Biliary Atresia and Biliary CirrhosisA new research paper was published in Aging (Aging-US) Volume 15, Issue 11, entitled, “Senescence and senotherapies in biliary atresia and biliary cirrhosis.”
Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arise in biliary atresia (BA), the first cause of pediatric liver transplantation. Alternatives to transplantation are needed. In this new study, researchers Giulia Jannone, Eliano Bonaccorsi Riani, Catherine de Magnée, Roberto Tambucci, Jonathan Evraerts, Joachim Ravau, Pamela Baldin, Caroline Bouzin, Axelle Loriot, Laurent Gatto, Anabelle Decottignies, Mustapha Najimi, and Etienne Marc Sokal from the Université catholique de Louvai...
2023-06-2803 min
Aging-USp21 Facilitates Chronic Lung Inflammation via Epithelial and Endothelial CellsA new research paper was published on the cover of Aging (Aging-US) Volume 15, Issue 7, entitled, “p21 facilitates chronic lung inflammation via epithelial and endothelial cells.”
Cellular senescence is a stable state of cell cycle arrest that regulates tissue integrity and protects the organism from tumorigenesis. However, the accumulation of senescent cells during aging contributes to age-related pathologies. One such pathology is chronic lung inflammation.
p21 (CDKN1A) regulates cellular senescence via inhibition of cyclin-dependent kinases (CDKs). However, its role in chronic lung inflammation and functional impact on chronic lung disease, where senescent cells accumulate, is less understood. In this new stud...
2023-04-1803 min
shrIvaiShNava+upanyAsAH श्रीवैष्णवोपन्यासाःST_20220325_Dushyanth_Sridhar_Rangaraj_Pandey_P21_The_Injustic.mp3ST_20220325_Dushyanth_Sridhar_Rangaraj_Pandey_P21_The_Injustic.mp3
2022-10-1825 min
Ngakak semaunya bareng Stand Up Comedy Indonesia!Febri Jadi Pengacara Putri | Berkas Ferdy Sambo P21 | Bantuan untuk PakistanJAKARTA, KOMPAS.TV Berikut adalah berita terpopuler yang terjadi pada hari ini, Rabu, 28 September 2022:
(00:18) Mantan juru bicara Komisi Pemberantasan Korupsi (KPK) Febri Diansyah membenarkan dirinya menjadi tim kuasa hukum istri Ferdy Sambo, Putri Candrawathi.
(01:18) Berkas pembunuhan berencana dan berkas perintangan penyelidikan atau obstruction of justice, kasus pembunuhan berencana Brigadir Yosua telah dinyatakan P21 atau lengkap.
(02:07) Bantuan Indonesia berupa ribuan paket bahan kebutuhan sehari-hari, tiba di Pakistan pada Selasa (27/9) pagi waktu setempat. Bantuan diterima langsung oleh Menteri bidang tenaga kerja Pakistan, Saeed Ghani.
Saran dan kolaborasi: podcast@kgmedia.id
2022-09-2902 min
Dernancourt Uniting Church11/8/22 - Montaz Ali - 5 Minute Thought For The Day P21 - Is The Gospel For Christians? - Romans 111/8/22 - Montaz Ali - 5 Minute Thought For The Day P21 - Is The Gospel For Christians? - Romans 1 by Dernancourt Uniting Church
2022-08-1106 min
WBSRocks: Scaling Growth with AI, Enterprise Software, and Digital TransformationWBSP348: Grow Your Business by Understanding Epicor Prophet 21's Capabilities, an Objective Panel DiscussionSend us a textEpicor Prophet 21 has always been extremely popular among industrial distributors. But is Epicor P21 fit for all businesses? Can it work for manufacturing as well as distribution? How about businesses that might manufacture as well as distribute? How is it different from other Epicor products such as Kinetic and Eclipse? Has it been upgraded to the cloud version? How cloud-native would it be? Would there be any limitations, such as the inability to open multiple windows or enterprise search? These are the questions you are going to have if you are thinking of...
2022-07-121h 00
Podcast de La TarantelaANY7-P21-237- La Tarantela Radio SocialANY7-P21-237- La Tarantela Radio Social
Vint-i-unè programa 7º temporada, total 237 ¡HEM TORNAT AL BOCARADIO! Avui destaquem "AlFoNS de la QuEStiO " música d'autor en directe, després El "Momento Holderlin" 1 assaig, 1 relat i 1 conte, El Maldito Bastardo de Harry Callahan" especial Oscars, a La Cuina de la Loli , Buñuelos de bacalao y Batido de fresas " Mi canción es un HIT ,"Beat" de Michael Jackson al We can Weeckend 4 expos de BCN i "Paisatges sonors", que vagi de gust i escolteu molta Ràdio.
2022-03-301h 02
2021-12-0710h 53
Tech & Learning’s Honor RoleThe Honor Role Episode 23: Lil KelloggLillian Kellogg has dedicated her career to education and has over 25 years of experience in working with schools and libraries in the field of educational technology. She is a member of the board of directors for the Partnership for 21st Century Skills (P21) and the Consortium for School Networking (CoSN) and a past board member of the Software and Information Industry Association (SIIA). She co-chairs CoSN's Empowering the 21st Century Superintendent initiative and also serves as a member of the Executive and Finance Committees for P21 and CoSN. As vice president of client services for ENA, Lillian oversaw marketing as...
2021-10-2037 min
Driven by DCKAP35. How Integration With P21 & the 3M Marketplace Improved Online Sales for C.W. HaydenChris Brackett is the Vice President of Operations & General Manager at C.W. Hayden, and he recently sat down with DCKAP’s Founder and CEO, Karthik Chidambaram. Their conversation spans through the incredible journey Chris has had within the company, into the mindset they hold on early adoption of technology, their most recent integration with Cloras to help connect their 3M Marketplace with Epicor P21, and more!
With their long standing experience in the distribution space, Chris explains how each decision they’ve made in order to continue to grow, and to not only follow the growth of t...
2021-09-2114 min
Making It RealThe Power of 21 & Help Clients Take Back Their PowerToday’s guest, Marquetta Spant, is the founder of P21 Mind-Body Wellness Coaching and is here to tell us about her program. In this episode, we talk about… Marquetta’s health journey, which involved getting to the bottom of hormonal imbalance issues. The importance of doing your own research and becoming your own best advocate for your health. The butterfly method for assessing four major pillars that affect your health. How and why Marquetta uses Meal Garden to help her clients. The importance of working on the emotional and perceptional side of things, rather than ju...
2021-08-1119 min
OncotargetOncotarget: Esomeprazole and Tumor ControlThis week's cover paper of Oncotarget (Volume 12, Issue 14) is entitled, "Esomeprazole enhances the effect of ionizing radiation to improve tumor control," by researchers from Baylor College of Medicine, University of Texas MD Anderson Cancer Center, and Texas Children’s Hospital.
Abstract:
The resistance of cancer cells to radiation-based treatment is a major clinical challenge confounding standard of care in cancer. This problem is particularly notable in many solid tumors where cancer cells are only partially responsive to radiation therapy. Combination of radiation with radiosensitizers is able to enhance tumor cell killing. However, currently available radiosensitizers are associated with significant normal ti...
2021-07-0804 min
Gerentes 360: Crecimiento Empresarial para Gerentes, CEOs, Empresarios(as) y Emprendedores(as)[PODCAST DIARIO] Jeff Bezos se retira de Amazon en medio de buenas noticias y el Pentágono cancela el contrato JEDI con MicrosoftHoy miércoles 7 de julio de 2021 en Noticias Diarias de Gerentes 360: Jeff Bezos se retira de Amazon en medio de buenas noticias y el Pentágono cancela el contrato JEDI con Microsoft. Puedes obtener más información en la página web del episodio [https://g360.blog/p21]: www.g360.blog/p21 [https://g360.blog/p21]
Este episodio del Podcast de Noticias Diarias de Gerentes 360 es traído por la MasterClass VIP de Ecommerce Exitoso [https://www.internetconresultados.com/]. ¿Quieres conocer cuál es la forma correcta de crear un Comercio Electrónico o Ecommerce Exitoso? Además, entender el rol que...
2021-07-0708 min
Podcast SPEKTRUM-NTT.COMBawang Merah Malaka Menuju P21, Araksi NTT Apresiasi Polda NTT dan Kejati NTTKasus Bawang Merah Malaka P21, Araksi NTT Apresiasi Polda NTT dan Kejati NTT
2021-05-0702 min
Shofar Tableview SermonsInsideOUT l Holy Spirit l P21 l Discernment 101 | Retief UysInsideOUT l Holy Spirit l P21 l Discernment 101 | Retief Uys
2020-11-1520 min
Interpreting the PentateuchP21 Numbers 15-21 Moses Strikes the RockIn the twenty-first lesson of the Pentateuch series, we consider the second set of four incidents of grumbling during the Israelite’s 40 years of wandering with a focus on Moses striking the rock and why God responded with such harsh punishment.
The post P21 Numbers 15-21 Moses Strikes the Rock first appeared on Observe the Word.
2020-10-2544 min
El Río que Nos LlevaEl Río que Nos LLeva-P21-"El Emocionario"El Río que Nos LLeva-P21-"El Emocionario"
Radio24online-ElRioqueNosLleva-T1-P21_16-10-2020
Programa Nº21
Presentado por: Marta Prieto Asirón
Invitado: Eduardo Bieger
2020-10-191h 00
El Lado del BienEl Lado del Bien-P21-"Liderazgo POST COVID-19, Empresas con Propósito"El Lado del Bien-P21-"Liderazgo POST COVID-19, Empresas con Propósito"
Programa Nº 21
Radio24online-ElLadodelBien-T1-P21_25-09-2020
Viernes 25 de Septiembre de 2020
Presentado por Elena Marcos
Invitados:
María Sánchez-Arjona Bonilla
Carlos Ruíz García
2020-09-281h 58
OncotargetOncotarget - ATM Inhibition Overcomes Resistance To Histone Deacetylase InhibitorThe cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug.
HDAC inhibitors appear to activate p21 expression via ataxia telangiectasia mutated activity.
The Oncotarget authors explored the potential synergistic interaction of the ATM inhibitor with romidepsin, given the potential complementary impact around p21. A synergistic cytotoxic...
2020-09-1604 min
Raising CainS1 P21 Thom DahlborgDeb sits down with authorThom Dahlborg, about his new book, From Heart to Head and Back Again, A Journey Through the Healthcare System due out in October. With well over thirty-five years of extensive healthcare leadership experience, Tom is a voice for relationship centered and compassionate care, servant leadership and quality and systems improvement. An author, leader and advisor, he is also an internationally recognized speaker and writer with an expertise in healthCARING models, heart and mind communication, courageous vulnerability, systems thinking and improvement, stopping bullying, adverse childhood experiences (ACES) and bringing “love in action” to a...
2020-08-1542 min
2020-06-231h 32
Life According To Sabrina Ben Salmi BScEpisode #64: Interview: Prof Dr Ger Graus OBE Global Director of Education at KidZaniaProf Dr Ger Graus OBEGlobal Director of Education at KidZaniaLinkedIn: https://www.linkedin.com/in/prof-dr-ger-graus-obe-335bb6115/"Children can only aspire to what they know exists ..." Introducing #TheNewNormal webinar series! ️https://www.docdroid.net/file/download/8F5KlLh/thenewnormal-a-webinar-series-for-school-educators-from-pearson-pdf.pdfBIOGRAPHYDr Ger Graus OBE is a renowned figure in the field of education, where, since March 2017, he holds the position of the first Global Director of Education at...
2020-05-1200 min
ー A History of Abstract Algebra by I.Kleiner ー 長岡亮介数学勉強会第12回（p21-22）2.1.4 Analysisレポート https://akasakas.cool/wp-content/uploads/2020/05/第12回2.1.4-Analysis20190510勉強会-.pdf
https://akasakas.cool/ カテゴリーA History of Abstract Algebra
第12回 （p21-22）
2 History of Group Theory
2.1.4 Analysis解析
解析関数というのは、多変数関数で微分可能なもの、実関数は微分可能というのだが、一般に複素変数の関数では微分可能と言わないで解析的という。解析的とは、微分可能よりもう少し条件が厳しくて複素平面というかこの場合はn次元上の全てのところでべき級数に展開される、そういうような条件を満たすもの。
リー（Marius Sophus Lie, 1842ー1899）は、自らをアーベル（Niels Henriｋ Abel：１８０２−１８２９享年27歳）、ガロア（Evariste Galois：１８１１−１８３２享年20歳）の後継者と考えていて、連続変換群を定義する。
リーの研究は、ピカール（Charles Émile Picard、1856ー1941）とビジョー（Ernest Vessiot 1865 ー1952)によるリー論のその後の公式化を基礎付けるものだった。
ポアンカレ（Jules-Henri Poincaré 1854ー1912）とクライン（Felix Christian Klein, 1849ー1925）は、1876年頃に「保型関数」とそれらに結びついた群で研究を始めた。
１９世紀初めに若くしてなくなった二人の数学者アーベルとガロアの研究は、１９世紀後半には多くの後継者たちによって、群論として体系化された。
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Send in a voice message: https://anchor.fm/tecum/message
2020-05-1216 min
Jack Taylor- English Language Support Podcast!Project Based Learning (PBL) and Mobile learning task by Jack TaylorIn this podcast I discuss the coronavirus response project that I have developed along with members of my cohort. The podcast includes a step by step breakdown of the project, a description about how the students will be assessed, some advice about how to use mobile phones and technology to undertake the project, and a message to my students.
This project was designed along with members of my cohort Todd Sills, Tang Smith, John Garcia, and William Martinez, and I also consulted with some of my former students 'Jarvan' and 'Will'
References
Ascd...
2020-04-2706 min
Memoria de MujeresCambiosFuente: Clara Coria y otras. Los cambios en la vida d elas mujeres. Temores, mitos y estrategias. p21
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Send in a voice message: https://podcasters.spotify.com/pod/show/memoria-de-mujeres/message
2020-04-2601 min
ResistiréRadio24online-Resistire-T1-P21_10-04-2020Radio24online-Resistire-T1-P21_10-04-2020
Presentado por Ignacio Parra
Colaboradores: Fernando Mairata
Invitado: Juan Julian Elola
Tema:Cómo será el día de mañana
2020-04-1459 min
2020-02-2010 min
2019-11-301h 59
La dama de las camelias - Alexandre DumasLa Dama de las Camelias P21/27Parte 21 de 27 de la lectura del libro "La Dama de las Camelias" de Alejandro Dumas (s.xix)- novela basada en hechos reales-
2019-10-2313 min
After Office RadioAfter Office Radio - Programa del 23/08/2019 - CompletoAfter Office Radio POR LARZ.COM.AR (T1 - P21)
# SECCIÓN # TODOLOQUEESTÁBIEN
#NACHOSYPOCHOCLOS
#EQUIPO: Alba Burgos, Mariano Vaca, Laila Rott y Gilda Carletti.
2019-08-2653 min
2019-08-101h 51
Observe the WordP21 Numbers 15-21 Moses Strikes the RockIn the twenty-first lesson of the Pentateuch series, we consider the second set of four incidents of grumbling during the Israelite's 40 years of wandering with a focus on Moses striking the rock and why God responded with such harsh punishment.
2019-06-2644 minObserve the WordP21 Numbers 15-21 Moses Strikes the RockIn the twenty-first lesson of the Pentateuch series, we consider the second set of four incidents of grumbling during the Israelite’s 40 years of wandering with a focus on Moses striking the rock and why God responded with such harsh punishment.
The post P21 Numbers 15-21 Moses Strikes the Rock first appeared on Observe the Word.
2019-06-2644 minOtra Mirada Y Un Poco De Todo - RTTOtra mirada y un poco de todo T4-P21 Belgrano y MarechalPor Radio Trend Topicwww.radiotrendtopic.com.ar
2019-06-251h 31
Sysadmin Today PodcastSysadmin Today #59: Sharing StoriesIn this episode, I am going to share some of my recent experiences with Dell Servers, VMware, DNS, P21 and more. Host: Paul Joyner Email: paul@sysadmintoday.com Facebook: https://www.facebook.com/sysadmintoday Twitter: https://twitter.com/SysadminToday Show SponsorKaseya: IT Management Software and Monitoring Solutions Request a demo today at www.kaseya.com/sysadmintoday Show Links 3 ESXi Backup Methods using the Command-Linehttps://www.altaro.com/vmware/esxi-backup-command-line/ ESXi Host Configuration Backup Failshttps://communities.vmware.com/thread/567954 ...
2019-04-2738 min
Vocaciones en Red - Radio Trend TopicVocaciones T1-P21 Ingeniería informática: Francisco PirraPor Radio Trend Topicwww.radiotrendtopic.com.ar
2018-08-021h 00
2018-07-311h 00Sobremesa - Radio Trend TopicSobremesa T1-P21 Los superhéroes y la historia, la tragedia de Luzhniki y Terrazas en BairesPor Radio Trend Topicwww.radiotrendtopic.com.ar
2018-07-211h 50Otra Mirada Y Un Poco De Todo - RTTOtra mirada y un poco de todo T3-P21 Poesia Erotica con Jorge Beto
2018-02-2822 min
Beyond Devices PodcastWeek 114 – NR – Netflix Prices, Google Launch, Sonos EventThis week's episode kicks off with a discussion of Netflix's price increases, and the context and reason for those. Next, we do a deep dive on Google's event this week and all that it announced, from new Pixel phones to new members of the Home family and a few other products also unveiled. Lastly, we talk about the other event that happened on Wednesday this week, the launch of the first voice-enabled speaker from Sonos.
The show notes below include links to all these stories on Tech Narratives and original sources as appropriate.
News stories we covered:
• Netflix Price Increases:
Te...
2017-10-0600 min
Tech Narratives Podcast70 – October 4 2017This is Episode 70 of the Tech Narratives Podcast, for October 4, 2017.
If you're enjoying the podcast, you might also enjoy a subscription to the Tech Narratives site just as much (or possibly even more). There's a 30-day free trial, and after that it's $10/month. You can read more about what a subscription gets you at www.technarratives.com/become-a-subscriber/
Below is a listing of the news stories covered, the Tech Narratives item, and the source for each:
1. Sonos Launches First Voice Speaker, Adds Alexa Support For Older Devices
TN Link: https://wp.me/p8ecZ5-2QQ
Source Link at Sonos...
2017-10-0513 min
Kotobá Japonês Fluente - conversação e notícias em japonês nativo#24 - Terrenos abandonados aumenta no Japão por falta de pessoa | Kotobá Nihongo PodcastE ai, tudo bem? No episódio de hoje vamos aprender japonês de verdade com uma notícia de que tá aumentando terras abandonadas por falta de gente no Japão. Esse é o novo episódio do Kotobá Nihongo Podcast.
■■ A transcrição em japonês e português com as palavras chaves já estão disponível no site: kotoba.com.br/p21/ (é esse link mesmo)
■■ Seja VIP! É free! Faça parte da nossa comunidade de e-mail no Kotobá VIP: bitly.com/kotobavip
Não deixe de comentar o que aprendeu no episódio e sugerir os pró...
2017-06-0614 min
JAY MAGUIRETech One P21Tech One P21
Track List
1
Stratagem (Original Mix)
Josh Butler
Track:https://www.beatport.com/track/stratagem-original-mix/9074770
Label:https://www.beatport.com/label/rejected/4469
2
The Swindle (Original Mix)
Mihai Popoviciu
Track:https://www.beatport.com/release/the-swindle/1635169
Label:https://www.beatport.com/label/poker-flat-recordings/563
3
Mirror (Original Mix)
NTFO
Track:https://www.beatport.com/track/mirror-original-mix/9150962
Label;https://www.beatport.com/label/objektivity/3914
4
EXTASY (Original Mix)
Joeski
Track:https://www.beatport.com/track/extasy-original-mix/9074780
Label:https://www.beatport.com/label/kittball/12909
5
Myself (Original Mix)
Dakar
Track:https://www.beatport.com/track/myself-original-mix/9113550
Label:https://www.beatport.com/label/yoshitoshi-recordings/2063
6
Brothers feat...
2017-06-0257 minOtra Mirada Y Un Poco De Todo - RTTOtra mirada y un poco de todo T2-P21 Ferrocarril Argentino Parte 1 + Audio de Peron
2017-03-1130 min
AD ALTA VOCE - Martin Eden di Jack LondonMARTIN EDEN di J LONDON P21MASSIMO POPOLIZIO LEGGE MARTIN EDEN di J LONDON P21
2016-11-1829 min
Balonmano Solo Para PrivilegiadosDescripción de Balonmano SPP_T4_P21_27.04.2016Descripción de Balonmano SPP_T4_P21_27.04.2016
PROGRAMA 04X21
Repaso a la actualidad del mundo del Balonmano Base en España.
MUNDIALEANDO:
Repaso de los Sectores Femeninos y Masculinos Juveniles.
Entrevistas con los entrenadores del Sector E Juvenil Masculino:
Ivan Pelicano entrenador BM Plasencia.
Carlos López entrenador ARS Palma de Río.
Manuel Nuñez entrenador INDUPIME Basauri.
Ángel Castaño entrenador Academia BM. Alcobendas.
Monólocos:
DHF
DHPM
DHPF
Balonmano Playa
Presentado: Paula San Esteban Glez
Técnico: Javier Nicolas
2016-04-2753 min
Podcast CUARTO MILENIOCuarto milenio.t11.p21.total 439.(31.01.2016)by.blasramblas.sound.extractCUARTO MILENIO.T11.P21.TOTAL 439.(31.01.2016)BY.BLASRAMBLAS.SOUND.EXTRACT
«ANONYMOUS», «RASTREADORES DE LO INVISIBLE» Y «LOARRE: EL CASTILLO DEL MISTERIO»
Han evitado atentados del estado islámico, hackeado ordenadores de corruptos, publicado datos de criminales, acosado a acosadores o denunciado a pederastas y narcotraficantes: Se hacen llamar Anonymous y aparecen siempre tras una siniestra máscara. Actúan en las redes al margen de la ley, muchos consideran que incumpliéndola. ¿Cómo surgieron y quiénes están detrás de este poderoso grupo virtual? ¿Son justicieros o son delincuentes? Todo son incógnitas alrededor de este misterioso conjunto de nuevos vengado...
2016-02-022h 04
Podcast de Tenemos el PoderHumala y frases en defensa Nadine Heredia / ¿Serenazgo (Patrullaje Municipal) con armas? - Tenemos el poder [t03/p21]Programa emitido el 02/06/15
Contenido:
Ollanta Humala y las 10 frases en defensa a Nadine Heredia,[¿ESTARIAS DEACUERDO QUE LIMA ESTE PROTEGIDA DE LA DELINCUENCIA ADEMAS DE LOS
POLICIAS CON SERENOS CON ARMAS DE FUEGO?,Universidad creó polémica por reglas para vestirse a alumnos ,AUNQUE USTED NO LO CREA… CON VALERIE REYES,Cosas que tu novio hace con su amiguita. Y MUCHO MÁS...
Tenemos el Poder: Es el programa de radio online que no esperabas con la amena y apasionada locución de Valerie, Siu, Diego y Tony Maceta. En donde con nuestra amable, locuaz, amena y ácida locución hablaremo...
2015-06-032h 01
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 14/19Establishment of a clonal immortalized human mesenchymal stem cell line expressing hTERT using lentiviral gene transferZiel:
1)Etablierung einer immortalisierten hMSC-Zelllinie durch lentivirale hTERT-Transduktion.
2)Untersuchung der biologischen Effekt einer lentiviralen Transduktion von hTERT auf hMSCs.
3)Aufklärung des Transformationspotenyials von hTERT-transduzierten hMSCs.
Material und Methoden:
hMSCs wurden mit Lentiviren, die hTERT enthieten, transduziert. Konale hMSCs-hTERT wurden durch Isolation einzelner Zellen gewonnen. Die Expression von hTERT wurde mittels RT-PCR bestätigt. Die Zellproliferation wurde durch morphologische Beobachtung und Berechnung der “population doubling level”(PDL) und “population doubling time”(PDT) überwacht. Die Verhinderung der Seneszenz durch hTERT-Transduktion wurde durch Seneszenz-assoziierte β-gal-Färbung bestätigt. Dabei dienten nicht-transduziert hMSCs als Kontrollen. Der Stammzellcharakter von hMSC-hTERT wurde durch adipogene, chondrogene und osteogene...
2012-07-0500 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06Critical Role of Transcription Cofactor PC4 in MammalsPC4 is a small protein with unique DNA-binding properties that affects transcription and has presumptive roles in DNA repair and genome stability. It was originally isolated from a cofactor fraction termed the ‘‘upstream stimulatory activity’’ (USA) of HeLa cell nuclear extracts. The cofactor has been shown to broadly enhance RNA polymerase II-driven gene transcription in the presence of activators (e.g., hormone receptors, viral activators, cell-specific and ubiquitous activators). Although such data imply that PC4 is a very important factor in vivo, human tumor cell lines with PC4 knockdowns are without obvious phenotypes. To further study the in vivo role of PC4...
2010-03-1500 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 09/19Regulation podosomaler Adhäsionen in primären humanen Makrophagen durch p21-activated kinase (PAK)-abhängige Signalwege
2009-01-2900 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 03/06The role of the PeBoW-complex in ribosome biogenesis and proliferation of mouse embryonic stem cellsThe hallmark of embryonic stem (ES) cells is their ability for self-renewal (capability of unlimited cell division without the loss of pluripotency) as well as for differentiation into all cell types of the adult organism. One factor supposed to be involved in self-renewal is the rapid proliferation rate of ES cells, which is coupled to an unusual cell cycle distribution with the majority of cells in S-phase and a very short G1-phase. This is linked to the lack of a functional G1/S-phase checkpoint, which allows the cells to enter the S-phase almost directly after mitosis. Generally, cells have...
2007-12-1700 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19Signaling pathways regulating LIM-kinase-1 activation and cofilin phosphorylation in activated plateletsThe activation of platelets is a central step during the physiological process of hemostasis and its understanding may lead us to control the pathophysiological process of intra-arterial thrombus formation and vascular occlusion, which can cause acute coronary syndrome and myocardial infarction. One of the important aspects of platelet activation is to understand the dynamic regulation and rearrangement of the cytoskeleton after stimulation. The morphological and functional changes of platelets require a drastic remodeling of the actin cytoskeleton regulated by numerous actin-binding proteins and signaling molecules such as the family of Rho-GTPases. The small GTPase Rho can regulate several aspects of...
2007-11-0500 min
Kids. Cable. Learning. The Official Podcast Channel of Cable in the Classroom!Virtual Schools and 21st Century SkillsAt the 2007 National Educational Computing Conference (NECC), Cable in the Classroom's Senior Director of Education Policy, Douglas Levin, had the opportunity to join Susan Patrick, President and CEO of the North American Council for Online Learning (NACOL), in presenting on the intersection of two emerging educational policy innovations: virtual schooling and 21st century skills.Cable in the Classroom, as the national education foundation of the U.S. cable industry, is a founding board member of the Partnership for 21st Century Skills. The Partnership is the leading advocacy organization infusing 21st Century skills into education.NACOL and...
2007-07-1804 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19Induktion von Wachstumsarrest und Apoptose in leukämischen Zelllinien durch selektive Inhibition der mutierten Rezeptortyrosinkinase FLT3Bei etwa 30 % der Patienten mit akuter myeloischer Leukämie (AML) können aktivierende Mutationen der Rezeptortyrosinkinase FLT3 gefunden werden. Damit ist FLT3 eines der am häufigsten mutierten Gene in der AML. Die Mutationen treten in zwei Regionen des FLT3-Rezeptors auf: Längenmutationen (FLT3-LM) in der juxtamembranösen Region (24 %) und Punktmutationen der Aktivationsschleife der zweiten Tyrosinkinasedomäne (FLT3-TKD-Mutationen;
7 %). FLT3-Mutationen verleihen Ba/F3-Zellen Unabhängigkeit von Interleukin-3. In einem Knochenmarktransplantationsmodell der Maus erzeugen FLT3-LM ein myeloproliferatives Syndrom und in Zusammenwirken mit PML-RARα eine akute Promyelozytenleukämie. Darüber hinaus scheint das Auftreten von FLT3-LM bei Patien...
2007-07-0500 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 07/19Latenz-assoziiertes-nukleäres-Antigen (LANA) des Humanen-Herpesvirus 8 (HHV 8) im AIDS-assoziierten Kaposi-SarkomBei dem Kaposi-Sarkom (KS) handelt es sich um eine eng mit dem Humanen-Herpes-Virus 8 (HHV 8) assoziierte vaskuläre Neoplasie. Die Etablierung eines kommerziell erhältlichen, stabilen Antikörpers gegen das virale „Latenz-assoziierte-nukleäre Antigen“ (LANA) von HHV 8 ermöglicht den Nachweis HHV-8-infizierter Zellen an Ex-vivo-
Paraffinmaterial. In dieser Arbeit wird diese Methode an einem Kollektiv aus insgesamt 61 Patienten mit HIV-assoziiertem KS angewendet, um einen Beitrag zur Beantwortung von bislang ungeklärten Fragen nach der quantitativen Verteilung von HHV 8 im Organismus und zur formalen Pathogenese des KS zu leisten. Das Kollektiv besteht aus diagnostischen Exzisaten (20 Früh- und 20 Spätstadien des KS) sowie au...
2007-06-1400 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19Treten die Varianten R72P des p53 Gens und S31R des p21 Gens bei Frauen mit einer Mammakarzinomerkrankung gehäuft auf?In einer klinischepidemiologische Fallkontrollstudie wurden insgesamt 550 periphere Blutproben von Patientinnen auf die Häufigkeit der Variante R72P im p53 Gen und S31R im p21 Gen untersucht. Nachdem die 275 Fallkontrollpaare mittels MALDI-TOF Massenspektroskopie analysiert wurden lagen 247 Fallkontrollen mit vollständigen Datensätzen vor.
Die Verteilung des p53 SNPs zeigte weder in der gepaarten noch in der Analyse der gesamten Daten einen signifikanten Unterschied zwischen der Kontroll- und der Karzinomgruppe. Somit scheint die Variante R72P alleine keinen Einfluß auf das Risiko einer Brustkrebserkrankung zu haben.
Die in der Literatur für mutiertes p53 angegebenen Daten konnten wir durch unsere Zahle...
2007-01-1800 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06Die Rolle von Pes1 in Ribosomenbiogenese und ZellzykluskontrolleProliferation erfordert die Koordination des Zellwachstums mit der Zellzyklusmaschinerie. Daten aus der Hefe belegen eine Funktion des Komplexes aus Nop7p, Ytm1p und Erb1p in der Ribosomenbiogenese, dem energieaufwendigsten Prozeß des Wachstums, und der Replikation. Die Beteiligung an diesen Schlüsselprozessen des Zellzyklus läßt die Vermutung zu, daß dieser Komplex eine Funktion bei der Koordination von Wachstum und Zellzyklusprogression innehat. In Säugern existiert ein trimerer Komplex, der sogenannte PeBoW-Komplex, der sich aus Pes1, WDR12 und Bop1 zusammensetzt, die einen hohen Grad an Homologie mit Nop7p, Ytm1p und Erb1p aufweisen. Der PeBoW-Komplex ist in Säuger...
2006-11-2900 minFakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06Molecular dissection of ephrinB reverse signalingSynapses form when highly motile dendritic filopodia establish axonal contacts.
When a synaptic contact is stabilized, it gives rise to the formation of a dendritic
spine, which has recently been shown to involve a number of molecules that mostly
regulate the actin cytoskeleton. Thus, it is not surprising that Eph receptor tyrosine
kinases, as known regulators of signaling pathways involved in actin cytoskeleton
remodeling, have been shown to be required for spine development and maintenance.
The main characteristic of interactions of the Eph receptor with its membrane
associated ephrin ligand is that they can propagate bidirectional signals. Both forward
(downstream...
2006-05-3000 min
2005-08-101h 12Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 01/06Die biologischen Effekte des Zellzyklusregulators p21 Waf1/Cip1 auf Proliferation und Apoptose Philadelphia-positiver Leukämien
2004-03-1500 min
Medizin - Open Access LMU - Teil 13/22Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum developmentPrevious studies revealed changes of pericentromeric heterochromatin arrangements in postmitotic Purkinje cells (PCs) during postnatal development in the mouse cerebellum (Manuelidis, 1985; Martou and De Boni, 2000). Here, we performed vibratome sections of mouse cerebellum (vermis) at P0 (day of birth), at various stages of the postnatal development (P2-P21), as well as in very young (P28) and 17-months-old adults. FISH was carried out on these sections with major mouse satellite DNA in combination with immunostaining of the nucleolar protein B23 (nucleophosmin). Laser confocal microscopy, 3D reconstructions and quantitative image analysis were employed to describe changes in the number and topology of...
2004-01-0100 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 01/06The synthesis and characterisation of halogen and nitro phenyl azide derivatives as highly energetic materials2,4,6-tribromophenyl azide was synthesised as previously described and fully characterised
using Infrared and Raman spectroscopy, elemental analysis, NMR spectroscopy (1H, 13C, 14N)
and X-ray structural analysis. 2,4,6-tribromophenyl azide was recrystallised from ethanol to
give pink needles which are monoclinic, with space group P21/n. The crystal packing diagram
of 2,4,6-tribromophenyl azide shows that every terminal N(3) atom of the azide group has two
intermolecular contacts with two bromine atoms of symetrically related molecules within the
unit cell. The intermolecular distances are N(3) to Br(2)* (x – 0.5, -y-0.5, z-0.5) 3.605 Å and
N(3) to Br(1)* (x + 1, y, z) 3.881 Å. These distances are both below the sum...
2001-10-1500 minMedizin - Open Access LMU - Teil 12/22Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1)Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells. Methods: Carcinoid cells were incubated without and with pioglitazone. Effects on growth were examined by cell count and cell cycle analysis. p21(waf1/cip1) expression was determined by Western blotting. Cytotoxicity assay was performed by FACS analysis. Results: Pioglitazone suppressed the growth and induced apoptosis of carcinoid cells. Additionally, pioglitazone significantly enhanced carcinoid cell death induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). The enhancement of TRAIL-induced apoptosis was associated with an upregulation of cyclin-dependent kinase...
2001-01-0100 minMedizin - Open Access LMU - Teil 10/22Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras.
1993-01-1500 minMedizin - Open Access LMU - Teil 10/22Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic NeuronsLittle is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family. We have previously shown that the introduction of the oncogene product ras p21 into the cytoplasm of chick embryonic neurons can reproduce the survival and neurite-outgrowth promoting effects of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), and of ciliary neurotrophic factor (CNTF). To assess the potential signal- transducing role of endogenous ras p21, we introduced function-blocking anti-ras antibodies or...
1993-01-0100 min