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Coaching with Confidence and Care2026-04-2319 minLeadership Variations: Unfiltered2026-04-1326 minStrategi dan Eksekusi2026-04-0421 minCharting the Future with PCC2026-04-0353 minCoaching with Confidence and Care2026-04-0319 minBetter Living Through Data2026-03-3110 minCoaching with Confidence and Care2026-03-2014 minLeadership Variations: Unfiltered2026-03-1026 minCoaching with Confidence and Care2026-03-0915 minHeart Glow CEO®2026-03-0520 minCoaching with Confidence and Care2026-02-1912 minCoaching with Confidence and Care2026-02-1914 minLeadership Variations: Unfiltered2026-02-1025 minCoaching with Confidence and Care2026-01-3023 minLeadership Variations: Unfiltered2026-01-2026 minCoaching with Confidence and Care2026-01-1521 minCommunist Forum2026-01-1126 minHeart Glow CEO®2026-01-0634 minCoaching with Confidence and Care2025-12-3122 minCoaching with Confidence and Care2025-12-2332 minBetter Living Through Data2025-12-1709 minLeadership Variations: Unfiltered2025-12-0922 minCharting the Future with PCC2025-12-0545 minCoaching with Confidence and Care2025-12-0524 minLeadership Variations: Unfiltered2025-11-1122 minCoaching with Confidence and Care2025-11-0723 minHeart Glow CEO®2025-11-0418 minCharting the Future with PCC2025-10-2425 minLeadership Variations: Unfiltered2025-10-1418 minCharting the Future with PCC2025-10-1017 minCoaching with Confidence and Care2025-10-0923 minHeart Glow CEO®2025-10-0218 minCharting the Future with PCC2025-09-2617 minHeart Glow CEO®2025-09-2312 minくつ王レディオ
くつ王レディオ糖尿病薬メトホルミンがCOVID-19後遺症(PCC)リスクを64%低減? CIDEffect of Metformin on the Risk of Post–coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese: A Population-based Retrospective Cohort StudyCitationClin Infect Dis. Published online September 1, 2025. doi:10.1093/cid/ciaf429概要本研究は、過体重または肥満の成人において、COVID-19罹患後のPost–COVID-19 Condition(PCC、いわゆるLong COVID)発症リスクに対するメトホルミン投与の効果を検証した大規模後ろ向きコホート研究である。デザイン:ターゲットトライアルエミュレーションを用いた後ろ向きコホート研究。データソース:英国Clinical Practice Research Datalink Aurum(2020年3月~2023年7月)。対象:BMI ≥25 kg/m²の成人624,308人。直近1年以内にメトホルミン使用歴や禁忌がある者は除外。介入:COVID-19診断後90日以内にメトホルミンを新規開始した群(n=2,976)と、非使用群(n=1,866,637)を比較。アウトカム:診断後90〜365日にPCC診断コード、またはWHOが定義する25症状の少なくとも1つが新規に出現した場合をPCCと定義。主要解析:ITT解析でのPCC発症1年リスク差 −12.58%、HR 0.36(95%CI 0.32–0.41)。PP解析でもほぼ同様(RD −12.74%、HR 0.36)。サブグループ解析(表3, p.8):年齢:45歳未満 HR 0.23、45歳以上 HR 0.42。性別:男性 HR 0.36、女性 HR 0.38。糖尿病の有無:非糖尿病 HR 0.33、糖尿病 HR 0.39。BMI:過体重 HR 0.34、肥満 HR 0.39。SARS-CoV-2株:デルタ期 HR 0.33、オミクロン期 HR 0.32。→ 全ての層で一貫したPCCリスク低下が確認された。感度解析(表4, p.8):癌発症をネガティブコントロールとした解析では関連なし(HR 1.13)、結果の頑健性を支持。図2(p.7):累積発症曲線において、メトホルミン群は非使用群より明らかにPCC発症率が低い傾向を示した。メトホルミン開始は、過体重・肥満成人においてCOVID-19後のPCCリスクを有意に低減させた。抗炎症作用やSARS-CoV-2に対する抗ウイルス作用が機序の候補とされるが、因果関係を確定するにはさらなるRCTが必要である。一方で、正常体重者への一般化はできず、投与量や製剤の影響も未評価である。COVID-19後に過体重・肥満の成人がメトホルミンを早期に開始することで、PCC発症を抑制できる可能性がある。低コストで安全性の高い薬剤として、Long COVID対策に寄与する可能性が示唆された。方法結果考察結論
2025-09-1320 minLeadership Variations: Unfiltered2025-09-0918 minBeauty and the Biz2025-09-0232 minHeart Glow CEO®2025-08-1218 minHeart Glow CEO®2025-07-1815 minCoaching with Confidence and Care2025-07-1027 minHeart Glow CEO®2025-06-2613 minCoaching with Confidence and Care2025-06-2632 minHeart Glow CEO®2025-06-2115 minCoaching with Confidence and Care2025-06-1230 minCoaching with Confidence and Care2025-05-2825 minCommunist Forum2025-03-1019 minCommunist Forum2025-02-1044 minTracking Yes: A Guide to Everyday Magic - with Liz Wiltzen, PCC2024-12-021h 07Strategi dan Eksekusi2024-11-0405 minCoaching with Confidence and Care2024-10-2219 minLet\'s Talk! Podcast Collective2024-07-2157 minLet\'s Talk! Podcast Collective2024-05-2458 minLet\'s Talk! Podcast Collective2024-05-1158 minLet\'s Talk! Podcast Collective2024-04-2655 minLet\'s Talk! Podcast Collective2024-04-2658 minLet\'s Talk! Podcast Collective2024-03-2056 minLet\'s Talk! Podcast Collective2024-03-0259 minLet\'s Talk! Podcast Collective2024-02-1659 minLet\'s Talk! Podcast Collective2024-01-2656 minLet\'s Talk! Podcast Collective2024-01-2626 minSuccessFULL With ADHD2023-12-2037 minSuccessFULL With ADHD2023-12-1323 minStrategi dan Eksekusi2023-11-2308 minLet\'s Talk! Podcast Collective2023-10-3031 minSuccessFULL With ADHD2023-09-1321 minStrategi dan Eksekusi2023-06-1805 minStrategi dan Eksekusi2023-06-0511 minIt’s Hard Because We Say It Is™ with Coach Reggie2023-04-2426 minLet\'s Talk! Podcast Collective2023-03-1726 minLeave Better: Conversations of Impact for Business and Life2023-02-1333 minLet\'s Talk! Podcast Collective2023-01-2523 minIt’s Hard Because We Say It Is™ with Coach Reggie2023-01-1736 minLeave Better: Conversations of Impact for Business and Life2023-01-0222 minLet\'s Talk! Podcast Collective2022-12-2722 minLet\'s Talk! Podcast Collective2022-12-2723 minEmployment Law by PCC Lawyers2022-09-2345 minCascade CounterPoint2022-09-1402 minLeave Better: Conversations of Impact for Business and Life2022-07-1029 minSTEM Chronicle: The Podcast Series2022-05-0217 minSTEM Chronicle: The Podcast Series2022-03-2717 minSTEM Chronicle: The Podcast Series2022-02-2724 minSTEM Chronicle: The Podcast Series2022-01-1622 minIt’s Hard Because We Say It Is™ with Coach Reggie2022-01-0336 minSTEM Chronicle: The Podcast Series2021-12-1319 minSTEM Chronicle: The Podcast Series2021-11-0728 minSTEM Chronicle: The Podcast Series2021-10-0325 minIt’s Hard Because We Say It Is™ with Coach Reggie2021-09-2728 minSTEM Chronicle: The Podcast Series2021-09-0419 min