Shows
Base by Base205: Ancient RNA Expression Profiles from the Woolly Mammoth️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth
In this episode of PaperCast Base by Base, we explore how ancient RNA preserved in permafrost can reveal tissue-specific gene expression and regulatory dynamics in the extinct woolly mammoth.
Study Highlights:Researchers analyzed skeletal muscle and skin from ten Late Pleistocene woolly mammoths preserved in Siberian permafrost, extracting both ancient DNA and RNA to assess the authenticity and quality of the recovered molecules. Using alignment strategies optimized for short, damaged transcripts and mapping primarily to the Asian elephant genome, they identified characteristic damage patterns, exonic en...
2025-11-2117 min
Base by Base204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators
In this episode of PaperCast Base by Base, we explore how the StealTHY CRISPR platform sidesteps Cas9 immunogenicity to uncover metastasis drivers in immunocompetent and humanized cancer models.
Study Highlights:Researchers show that standard CRISPR-Cas9 tools and xenogeneic reporters provoke strong T cell responses in syngeneic and humanized mice, reshaping clonal architecture and suppressing metastasis.To overcome this, they develop StealTHY, a “hit-and-run” knockout strategy that pairs species-autologous Thy1 reporters with transient delivery of Cas9 protein, eliminating persistent immunogenic transgenes while preserving sgRNA library complexity.Across...
2025-11-2016 min
Base by Base203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and malignant tumors follow different evolutionary trajectories across birds and mammals, and what this reveals about cancer defenses across the tree of life.
Study Highlights:The authors combine necropsy data on tumor prevalence from hundreds of bird and mammal species with Bayesian multivariate phylogenetic generalized linear mixed models to test how benign and malignant tumors relate to macroevolutionary processes. They show that prevalence of both benign and malignant tumors increases with body mass, confirming th...
2025-11-1918 min
Base by Base202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues
In this episode of PaperCast Base by Base, we explore how Stereo-seq V2 delivers high-resolution spatial mapping of total RNA in FFPE samples, from mouse brain to breast cancer and tuberculosis lung tissue.
Study Highlights:The authors introduce Stereo-seq V2, a random-priming spatial transcriptomics platform that captures total RNA in situ on FFPE sections at single-cell resolution. By benchmarking against earlier Stereo-seq and other spatial methods in the mouse brain, they demonstrate improved gene detection, uniform gene body coverage, and robust profiling of non-coding RN...
2025-11-1917 min
Base by Base201: Sex, Smoking, and Somatic Selection in the Bladder️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex DNA sequencing of normal human bladder tissue reveals sex- and smoking-related biases in the selection of somatic mutations and cancer driver clones.
Study Highlights:Researchers applied ultradeep duplex DNA sequencing at around 5,000× coverage to 79 normal bladder urothelium samples from 45 deceased donors, targeting 16 genes known to drive clonal expansions and bladder tumors. They identified more than 64,000 somatic mutations and thousands of clonal driver events, allowing precise estimates of positive and negative selection across genes suc...
2025-11-1714 min
Base by Base199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity️ Episode 199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity
In this episode of PaperCast Base by Base, we explore how loss-of-function mutations in the endolysosomal exonuclease PLD4 cause a monogenic form of systemic lupus erythematosus, reshaping our understanding of nucleic acid sensing and interferon-driven autoimmunity.
Study Highlights:This study identifies biallelic loss-of-function PLD4 mutations in five patients with systemic lupus erythematosus, all presenting with severe lupus nephritis and hematologic involvement. Using whole-exome sequencing, structural modelling and biochemical assays, the authors show that these PLD4 variants markedly impair single-stranded DNA and RNA exonuclease activity, le...
2025-11-1513 min
Base by Base198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells
In this episode of PaperCast Base by Base, we explore how physical forces in the tumor microenvironment can push melanoma cells to switch from a pigment-producing, proliferative state into an invasive, drug-tolerant one, focusing on new work that links mechanical confinement, chromatin remodeling, and neuronal-like programs in cancer.
Study Highlights:Using a zebrafish model of BRAFV600E-driven melanoma together with human tumor samples and single-cell transcriptomics, the authors identify a subpopulation of tumor cells at the tumor–microenvironment interface that displays elongated nuclei and...
2025-11-1415 min
Base by Base195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease️ Episode 195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease
In this episode of PaperCast Base by Base, we explore how a subset of brain immune cells adopts a lymphoid-like program that helps contain inflammation and protect neural circuits in Alzheimer’s disease models.
Study Highlights: Using mouse models of amyloid pathology and human Alzheimer’s brain tissue, the authors identify plaque-associated microglia with reduced PU.1 expression that cluster around deposits and express an unexpected set of lymphoid receptors, including CD28. By genetically tuning PU.1 levels specifically in microglia, they show that lowering PU.1 is...
2025-11-1118 min
Base by Base169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance
In this episode of PaperCast Base by Base, we explore how a comprehensive deep mutational scan of the human insulin receptor ectodomain maps the effects of ~14,000 missense variants on surface expression, insulin binding, and downstream signalling, creating a sequence–function atlas to improve diagnosis and treatment of severe insulin resistance.
Study Highlights:The authors constructed a saturation mutagenesis library across residues 28–955 of INSR and used barcoded, pooled cell-based assays to quantify variant effects on receptor expression, insulin or antibody binding, and ma...
2025-10-1621 min
Base by Base167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution
In this episode of PaperCast Base by Base, we explore a Cell Genomics study introducing DeepScence, a deep-learning autoencoder that leverages a compact “CoreScence” gene set to identify senescent cells across single-cell and spatial transcriptomics data, outperforming marker- and gene set–based approaches.
Study Highlights:The authors systematically compared nine published senescence gene sets and distilled a consensus 39‑gene CoreScence panel that is consistently associated with senescence across tissues and conditions. DeepScence models expression counts with a zero‑inflated negative binomial autoencoder whose bottleneck s...
2025-10-1421 min
Base by Base166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments
In this episode of PaperCast Base by Base, we explore a Cell study that uses single-particle cryo-EM to reveal the stepwise, synergistic mechanism by which coronin, cofilin, and AIP1 drive rapid actin filament disassembly in eukaryotic cells.
Study Highlights:The authors solve a series of cryo-EM structures showing that coronin binds cooperatively to F-actin, opens a molecular backdoor to accelerate inorganic phosphate release, and undertwists the filament to prime it for cofilin binding. Cofilin then binds in a strand-restricted cooperative manner th...
2025-10-1313 min
Base by Base158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?️ Episode 158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?
In this episode of PaperCast Base by Base, we explore how small sequence changes—“interruptions”—within expanded tandem repeats shape the onset and severity of repeat expansion disorders, and a new mechanistic model that may explain how these interruptions are gained and lost across generations.
Study Highlights:Interruptions within repeat tracts can dampen somatic expansion and shift clinical trajectories, helping to explain variability in age at onset and phenotype across disorders such as Huntington’s disease, myotonic dystrophy type 1, spinocerebellar ataxias, and fragile X. A...
2025-10-0522 min
Base by Base157: Synthetic gametes and the non-identity problem: the babies of tomorrow️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow
In this episode of PaperCast Base by Base, we explore how synthetic DNA technologies may enable the creation of synthetic gametes and why this possibility forces a rethinking of identity, harm, and responsibility in human reproduction.
Study Highlights:The authors argue that while building a full human genome remains infeasible today, engineering haploid genomes for gametes is a nearer-term and more tractable objective, drawing on advances such as synthetic chromosomes in yeast. They analyze how synthetic gametes differ ethically from embryo editing an...
2025-10-0414 min
Base by Base149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how patrilineal social structures and intergroup competition can reshape genetic diversity, offering a cultural explanation for the striking male‑specific bottleneck observed 5,000–7,000 years ago across the Old World.
Study Highlights:The authors synthesize anthropological theory, population genomics, and mathematical modeling to test whether competition among patrilineal kin groups could drive a sharp reduction in Y‑chromosome diversity while leaving mitochondrial lineages relatively stable. They introduce an analytical Lotka–Volterra framework and a computational grid simulation to...
2025-09-2615 min
Base by Base139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
In this episode of PaperCast Base by Base, we explore the development of MosCoverY, a computational method designed to detect and quantify mosaic loss of the Y chromosome (mLOY) from exome and whole-genome sequencing data. This condition, the most common somatic mutation in men, is strongly linked with aging and several diseases.
Study Highlights:The researchers introduced MosCoverY, a tool that focuses on single-copy genes of the Y chromosome and normalizes their coverage against carefully matched autosomal exons. Th...
2025-09-1614 min
Base by Base138: Social exposome and brain health outcomes of dementia across Latin America️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America
In this episode of PaperCast Base by Base, we explore how a multidimensional social exposome across the lifespan—covering education, food insecurity, financial status, assets, access to healthcare, childhood labor, subjective socioeconomic status, childhood experiences, traumatic events, and relationships—relates to brain health and dementia outcomes in Latin America. The study analyzes 2,211 participants from Argentina, Brazil, Chile, Colombia, Mexico, and Peru, spanning healthy controls, Alzheimer’s disease, and frontotemporal lobar degeneration.
Study Highlights:Researchers built a global multidimensional social exposome score using expert c...
2025-09-1519 min
Base by Base137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
In this episode of PaperCast Base by Base, we explore how a sweeping expansion of the RNA-binding proteome has reframed long‑held assumptions about RNA–protein interactions, spotlighting ‘non‑canonical’ RBPs and the emerging concept of riboregulation—RNA directly regulating protein function.
Study Highlights:The authors synthesize discovery platforms that tripled the number of candidate RBPs, including UV crosslinking–based interactome capture (RIC/eRIC), silica‑based workflows (TRAPP/2C), and organic‑phase methods (OOPS/XRNAX), together with mass spectrometry to map RNA‑binding regions across the proteome. T...
2025-09-1525 min
Base by Base135: Global impact of micronutrients in modern human evolution️ Episode 135: Global impact of micronutrients in modern human evolution
In this episode of PaperCast Base by Base, we explore how dietary micronutrients have influenced modern human evolution. The study investigates the role of essential minerals in shaping genetic adaptation and highlights the health risks posed by imbalances in micronutrient availability worldwide.
Study Highlights:Researchers analyzed 276 genes linked to 13 micronutrients across 40 diverse human populations. Using whole-genome data and evolutionary simulations, they identified widespread signatures of positive selection in genes associated with nutrient uptake, metabolism, and regulation. Their findings suggest that deficiencies in elements such as se...
2025-09-1214 min
Base by Base134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk️ Episode 134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk
In this episode of PaperCast Base by Base, we explore how single-cell RNA sequencing of Barrett’s esophagus (BE), esophageal adenocarcinoma (EAC), and matched normal tissues reveals which cell types carry germline-linked risk and shape progression toward cancer.
Study Highlights:The authors profiled epithelial, stromal, endothelial, and immune cells with 10x scRNA-seq and integrated genome-wide association data using partitioned heritability to map risk to specific cell types. They show that EAC development is driven more by local cellular programs than BE, with intestinal metaplasia cell...
2025-09-1115 min
Base by Base123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease
In this episode of PaperCast Base by Base, we explore how de novo heterozygous ATP5F1A missense variants disrupt mitochondrial ATP synthase and manifest as pediatric neurological disorders, revealing a dominant‑negative mechanism and an isolated Complex V defect.
Study Highlights:The authors describe six probands with developmental delay, dystonia, pyramidal tract signs and failure to thrive, each carrying ATP5F1A variants clustered at the α–β or α–γ interfaces of the F1 sector of ATP synthase. In vivo CRISPR knock‑ins of o...
2025-08-3118 min
Base by Base122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences
In this episode of PaperCast Base by Base, we explore a study that investigates the molecular underpinnings of why certain diseases tend to co-occur. By using large-scale RNA sequencing data, the authors present a novel approach to identify disease co-occurrences, revealing a shared molecular basis in many comorbidities, particularly involving the immune system. The study introduces patient stratification based on gene expression profiles, which uncovers known and potential new disease associations, providing a framework for personalized approaches to managing comorbidities.
Study Highlights:The re...
2025-08-3019 min
Base by Base118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B
In this episode of PaperCast Base by Base, we explore how cancer cells co-opt a primate-specific KRAB zinc finger protein, ZNF93, to fine-tune the mutagenic enzyme APOBEC3B and manage replication stress.
Study Highlights:Using genome-wide KZFP binding maps, CUT&Tag, RNA-seq, and functional assays across multiple cancer cell lines, the authors identify ZNF93 as a proliferation-linked regulator enriched at promoters of young endonuclease-competent LINE-1 elements and as a direct repressor of APOBEC3B. ZNF93 knockdown consistently reduces proliferation, ac...
2025-08-2619 min
Base by Base116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation️ Episode 116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation
In this episode of PaperCast Base by Base, we explore how a seemingly “silent” synonymous mitochondrial DNA mutation can shape immune cell fitness, revealing cell type–specific selection in human T cells and a mechanistic link to mitochondrial translation dynamics.
Study Highlights:Using single-cell multiomics on peripheral blood from a healthy donor, the authors identify a mosaic synonymous variant in MT-CO1 (m.7076A>G, p.Gly391=) that is selectively depleted in CD8+ effector-memory T cells while remaining tolerated in other lineages. They show that...
2025-08-2415 min
Base by Base115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous SystemEpisode 115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System
In this episode of PaperCast Base by Base, we explore how an integrated multi‑omics and CRISPR interference atlas maps the function of the NF1 tumor suppressor neurofibromin in peripheral nerve cells and reveals context‑specific therapeutic sensitivities relevant to neurofibromatosis type 1 and related tumors.
Study Highlights:Using CRISPR interference in immortalized peripheral nerve cells, the authors systematically repressed NF1 and key upstream Ras regulators and profiled transcriptomes, phosphoproteomes, and drug responses to delineate neurofibromin’s roles. NF1 repres...
2025-08-2415 min
Base by Base114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique
In this episode of PaperCast Base by Base, we explore the development of a rapid and affordable HPV DNA test designed for cervical cancer screening in low-resource settings. The study introduces a one-hour, extraction-free loop-mediated isothermal amplification (LAMP) assay that directly processes cervicovaginal samples without complex infrastructure.
Study Highlights:The researchers designed a multiplex LAMP assay targeting HPV16, HPV18, and HPV45—the three HPV types most responsible for cervical cancer—along with a cellular control. Using a simple benchtop fluori...
2025-08-2216 min
Base by Base113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations
In this episode of PaperCast Base by Base, we explore how the Undiagnosed Diseases Network (UDN) applied whole‑genome sequencing and new, well‑calibrated statistics to jointly analyze diverse, ultra‑rare monogenic cases across the consortium, yielding confirmed and putative diagnoses while enabling privacy‑preserving cross‑cohort discovery via shareable summary statistics.
Study Highlights:The authors introduce RaMeDiES, a suite of analytical methods that detect gene‑level recurrence of deleterious de novo variants (RaMeDiES‑DN) and prioritize compound‑heterozygous configurations (RaMeDiES‑CH), with an individual‑level...
2025-08-2122 min
Base by Base112: Local Genetic Sex Differences in Quantitative Traits️ Episode 112: Local Genetic Sex Differences in Quantitative Traits
In this episode of PaperCast Base by Base, we explore how genetic differences between males and females are distributed across the genome, moving beyond global averages of heritability and correlation. The study introduces a fine-scale approach using LAVA to examine local genetic sex differences across 157 quantitative traits in the UK Biobank.
Study Highlights:The researchers analyzed sex-stratified GWAS summary statistics and partitioned the genome into nearly 2,500 loci. They estimated local heritabilities, genetic correlations, and equality of genetic effects, finding that nearly every trait had at least on...
2025-08-2021 min
Base by Base111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer
In this episode of PaperCast Base by Base, we explore the creation of HANCOCK, a comprehensive multimodal dataset designed to advance precision oncology in head and neck cancer. The study addresses the urgent need for large, publicly available datasets to improve biomarker discovery and outcome prediction in this challenging disease.
Study Highlights:The HANCOCK dataset integrates real-world data from 763 patients, including demographics, pathology, blood tests, surgery reports, and histologic images. By combining these modalities, the researchers created multimodal patient vectors that capture co...
2025-08-1917 min
Base by Base107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical DiseasesEpisode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases
In this episode of PaperCast Base by Base, we explore a large-scale genome-wide association study investigating the genetic underpinnings of pulpal and apical diseases. Using Finnish health registry data from over 485,000 individuals in the FinnGen cohort, researchers identified genetic loci linked to susceptibility to endodontic infections, independent of caries status.
Study Highlights:The study analyzed three phenotypes—Pulpal and apical diseases, Pulpitis, and Necrosis of pulp or apical periodontitis—identifying 15 independent loci with genome-wide significance. Strong associations were found near the HORM...
2025-08-1519 min
Base by Base104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillationEpisode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation
In this episode of PaperCast Base by Base, we explore a large cross-ancestry study that integrates genome-wide association results with plasma proteomics to map genetic architecture, nominate causal pathways and proteins, and boost risk prediction for atrial fibrillation (AF).
Study Highlights:The authors meta-analyzed AF across ancestries—more than two million participants overall—and reported 525 genome-wide significant loci among 168,007 AF cases, with PITX2 and ZFHX3 emerging as shared signals across populations. Gene prioritization and pathway enrichment reinforced core roles in musc...
2025-08-1216 min
Base by Base103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery
In this episode of PaperCast Base by Base, we explore how large-scale exome sequencing combined with explainable AI can predict adverse outcomes after surgery for congenital heart defects. Using a prospective cohort from the Pediatric Cardiac Genomics Consortium, the study links specific genetic pathways to real-world postoperative risks and shows how genomics sharpens clinical risk stratification.
Study Highlights: A prospective observational cohort of 2,253 patients underwent whole-exome sequencing; variants were prioritized with an AI genome-interpretation tool, cardiac phenotypes were auto-classified, and Bayesian networks quantified risk. Damaging de...
2025-08-1117 min
Base by Base102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese CohortEpisode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
In this episode of PaperCast Base by Base, we explore how large-scale pharmacogenomics translates to real-world care using data from the Taiwan Precision Medicine Initiative. We follow a Nature Communications study that analyzes gene–drug interactions across 486,956 Han Chinese participants, quantifying how pharmacogenetic risk variants shape adverse drug events and effectiveness in routine practice while situating the findings within broader themes such as gene–disease association, variant interpretation, functional and structural genomics, and clinical deployment of precision medicine.
Study Highlights:Using custom SNP...
2025-08-1014 min
Base by Base101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis
In this episode of PaperCast Base by Base, we explore how JAK2 inhibition with ruxolitinib can reshape clonal architecture in myeloproliferative neoplasms (MPN), favoring outgrowth of RAS‑pathway mutant subclones and altering patient outcomes. We situate these findings within the broader landscape of genomics, functional and structural genomics, and proteomics—touching on themes like gene–disease association, variant interpretation, and resistance mechanisms in targeted therapies.
Study Highlights:Using a longitudinal myelofibrosis cohort with paired molecular evaluations, the authors show that patients exposed to ruxolitinib preferentially acquire or expan...
2025-08-0918 min
Base by Base️ 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia In this episode of PaperCast Base by Base, we explore a groundbreaking study that maps the epigenomic landscape of Acute Myeloid Leukemia (AML) and develops powerful diagnostic and prognostic tools for clinical use. The research introduces the Acute Leukemia Methylome Atlas (ALMA), integrating large-scale DNA methylation data, machine learning, and long-read sequencing to refine subtype classification and predict patient outcomes. Study Highlights:The authors harmonized DNA methylation profiles from 3,314 patient samples across 11 cohorts to build ALMA, an interactive atlas that visualizes hematopoietic heterogeneity and en...
2025-08-0814 min
Base by Base️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integrated DNA methylation, RNA sequencing, and histone modification profiling across metastatic lesions reveal intraindividual epigenetic diversity underlying phenotypic subtypes of castration-resistant prostate cancer. Study Highlights: The research team performed multi-omic profiling combining reduced representation bisulfite sequencing, RNA sequencing, and H3K27ac and H3K27me3 profiling across 98 metastatic lesions from patients with castration-resistant prostate cancer. They found that, although epigenetic and transcriptomic landscapes are generally stable within individual patients, certain metastases display outlier DNA methylation an...
2025-08-0220 min
Base by Base️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore a genome‑wide association and fine‑mapping study in a Finnish cohort that identifies CFHR5 loss‑of‑function variants as independent protective factors against age‑related macular degeneration and investigates their impact on complement activation and retinal structure. Study Highlights:The researchers performed association testing, statistical finemapping, and conditional analyses in 12,495 AMD cases and 461,686 controls to resolve four major protective CFH locus haplotypes, two of which are driven by CFHR5 frameshift and missense var...
2025-07-3116 min
Base by Base️ 85: Genomic landscape of virus-associated cancers️ Episode 85: Genomic landscape of virus-associated cancers In this episode of PaperCast Base by Base, we explore the comparative genomic analysis of virus-positive and virus-negative tumors across nine cancer types linked to five oncogenic viruses uncovering epidemiological patterns, mutational signatures, and therapeutic implications. Study Highlights:The authors aggregated genomic data from 1,971 tumors spanning nine virus-associated cancers and performed comprehensive analyses of mutation burden and driver mutations across virus-positive and virus-negative cases. They identified that virus-positive tumors generally have a lower somatic mutation load but frequent mutations in RNA helicases DDX3X and EIF4A1 an...
2025-07-2423 min
Base by Base️ 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome️ Episode 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome In this episode of PaperCast Base by Base, we explore the discovery of rare variants in the orphan nuclear receptor gene NR6A1 as the genetic cause of a newly described autosomal dominant oculo-vertebral-renal (OVR) syndrome characterized by colobomatous microphthalmia, vertebral anomalies, and congenital kidney abnormalities. Study Highlights:We performed genome sequencing in six independent families affected by uveal coloboma with or without microphthalmia and identified six rare NR6A1 variants segregating with disease. Functional validation included in silico modeling predicting disrupted DNA bi...
2025-07-2317 min
Base by Base️ 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms️ Episode 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms In this episode of PaperCast Base by Base, we explore how single-cell RNA sequencing of patient-derived cortical organoids and postmortem brain tissue uncovers developmental and postnatal molecular changes in duplication 15q syndrome, a major genetic cause of autism. Study Highlights:The authors performed single-cell and single-nucleus transcriptomic profiling on cortical organoids and postmortem cortical samples from dup15q patients and matched controls to map cell-type specific gene expression changes across development and adulthood. They discovered a transient increase in glycolysis in deep-layer neurons an...
2025-07-2225 min
Base by Base️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms️ Episode 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms In this episode of PaperCast Base by Base, we explore how JAK2 inhibition by ruxolitinib reshapes clonal dynamics in myelofibrosis by mediating the expansion of RAS pathway-mutated clones in myeloproliferative neoplasms. Study Highlights:We conducted a longitudinal molecular analysis of myelofibrosis patients treated with ruxolitinib and observed a marked accumulation of RAS pathway mutations following JAK2 inhibitor exposure. Single-cell DNA sequencing and ex vivo treatment of patient-derived CD34+ cells demonstrated that ruxolitinib selectively enriches RAS-mutant clones even in the absence of JA...
2025-07-2119 min
Base by Base️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort️ Episode 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore a retrospective analysis of genetic and clinical data from the Taiwan Precision Medicine Initiative cohort to assess how actionable pharmacogenetic variants influence drug response and adverse events in nearly half a million Han Chinese individuals. Study Highlights:We performed a comprehensive survey of clinically actionable variants in 19 pharmacogenes affecting 58 commonly prescribed drugs and found that 99.9% of participants carried at least one actionable variant with an average of 4.3 variants per person....
2025-07-2021 min
Base by Base️ 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery️ Episode 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore the use of artificial intelligence–driven genome sequencing to predict clinical outcomes following surgery for congenital heart defects. Study Highlights:The authors conducted a prospective observational cohort study of 2,253 patients from the Pediatric Cardiac Genomics Consortium, integrating whole exome sequencing with pre- and post-operative clinical variables to identify damaging genotypes in chromatin-modifying and cilia-related genes.They applied an AI-based interpretation tool to pinpoint pathogenic variants and employed Bayesian networks to model cond...
2025-07-1916 min
Base by Base️ 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation️ Episode 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation In this episode of PaperCast Base by Base, we explore a cross-population genome-wide meta-analysis combined with proteomic profiling to enhance risk prediction and uncover molecular mechanisms underlying atrial fibrillation. Study Highlights:The authors conducted a meta-analysis of over 168,000 atrial fibrillation cases across diverse ancestries and identified 525 genome-wide significant loci. They integrated genomic data with large-scale proteomic profiling to discover 28 circulating proteins with potential causal roles in atrial fibrillation. Mendelian randomization analyses highlighted modifiable risk factors such as obesity and hypertension and revealed novel protein ta...
2025-07-1817 min
Base by Base️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer️ Episode 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer In this episode of PaperCast Base by Base, we explore the discovery and characterization of the interaction between the membrane protein TTYH2 and apolipoprotein E (APOE), and how this partnership drives lipid transfer within endosomal compartments. Study Highlights:Pull-down assays and mass spectrometry identified APOE as a binding partner of human TTYH2 in endosomes, and subcellular fractionation confirmed their colocalization within endosomal fractions. Cryo-EM structures of TTYH2–APOE complexes revealed that APOE binds to an epitope on the extracellular domain of the TTYH2 dime...
2025-07-1714 min
Base by Base️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity️ Episode 77: Range Extender: Unlocking Long-Distance Enhancer Activity In this episode of PaperCast Base by Base, we explore the discovery and functional characterization of a novel cis-acting element, termed REX, that mediates megabase-scale enhancer–promoter interactions and enables remote gene activation during limb development. Study Highlights:The authors performed in vivo enhancer-replacement experiments at the mouse Shh locus to demonstrate that bona fide short- and medium-range limb enhancers lack the capacity to activate target genes over megabase distances. They identified a conserved REX element adjacent to a long-range Sall1 enhancer that by itself has no e...
2025-07-1616 min
Base by Base️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage whole-genome sequence recovered from a high-status individual of the Old Kingdom excavated at the Nuwayrat necropolis and examine the evidence for multi-regional ancestry during early Dynastic Egypt. Study Highlights:The research team extracted and authenticated ancient DNA from a pot-burial dating to 2855–2570 cal BCE and generated a 2.02× coverage genome allowing comprehensive ancestry inference. Population genetic analyses revealed that approximately 78% of the genome traces back to North African Neolithic populations and 22% to Neolithic Mesopotami...
2025-07-1513 min
Base by Base️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years️ Episode 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years In this episode of PaperCast Base by Base, we explore a large-scale study published in Nature by Lemke et al. that leverages AlphaFold2-predicted and experimentally determined enzyme structures across 27 yeast species to reveal how metabolic properties have constrained and shaped enzyme structural evolution over 400 million years in the Saccharomycotina subphylum. Study Highlights:The authors analyzed over 11,000 enzyme structures across diverse yeast species to link sequence divergence in conserved regions to metabolic flux, enzyme abundance, and pathway membership. They found that enzymes in central me...
2025-07-1414 min
Base by Base️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR️ Episode 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR In this episode of PaperCast Base by Base, we explore a unified computational framework that integrates and benchmarks 21 T cell receptor–epitope binding prediction models to evaluate their performance on viral epitope repertoires and deep mutational scans. Study Highlights:The authors developed ePytope-TCR, which standardizes 18 general and three categorical prediction methods into a single interoperable platform compatible with common TCR repertoire formats. They assessed model performance on 638 epitope-specific TCRs from single-cell datasets and found that only a few predictors achieved moderate accuracy, exhibiting strong biases toward frequently studie...
2025-07-1320 min
Base by Base️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield️ Episode 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield In this episode of PaperCast Base by Base, we explore a study that evaluates how stratifying dementia patients by family history and age at onset can optimize the identification of diagnostically significant genetic variants in a clinical memory clinic setting, illustrating gene–disease association and variant interpretation through exome sequencing discoveries in neurodegenerative disease. Study Highlights:The authors analyzed 701 patients diagnosed with Alzheimer’s disease, frontotemporal dementia and other dementia subtypes and classified them into risk categories using a modified Goldman family history score combined with an ear...
2025-07-1215 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Shane Miller, Nick Weber, and Tricia Hoke: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Shane Miller, Nick Weber, and Tricia Hoke” WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahttps://tw...
2023-01-2512 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Jon Ferrara, Shane Miller, and Nick Weber: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Jon Ferrara, Shane Miller, and Nick Weber” WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahttps...
2022-10-1911 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Mike Gelb, Curt Cuscino, and Nick Weber: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Mike Gelb, Curt Cuscino, and Nick Weber”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahtt...
2022-05-0412 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: JJ Ramberg, Mike Gelb, and Nick Weber: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: JJ Ramberg, Mike Gelb, and Nick Weber”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahtt...
2022-03-0211 min
PapercastEp. 26. Era necesaria una cuarta película de Matrix?En el episodio de hoy, PaperCast, el podcast más chipocludo, hace serios comentarios sobre la saga de The Matrix y su cuarta películas. Además, Sony a presentado los nuevos videojuegos para PS4 y PS5, entre ellos destaca Spiderman 2. Y el Elimon habla largo y tendido sobre Shang Chi.
2022-02-271h 07PapercastTodo sobre el trailer filtrado de Spiderman / PaperCast, Podcast ep 25En el podcast regreso de vacaciones veraniegas, retomamos el trailer filtrado de spiderman y los sucesos alrededor de la filtración. Así como también vemos la muerte de lo que una vez fue una gran compañía, Blizzard. Y los conocedores hablan del final final de los finales de Evangelion.
2022-02-241h 30
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Curt Cuscino, Nick Weber, and Charlie Hinojosa: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Curt Cuscino, Nick Weber, and Charlie Hinojosa”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahtt...
2022-02-0911 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Curt Cuscino, Nick Weber, and Shane Miller: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Curt Cuscino, Nick Weber, and Shane Miller”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahtt...
2022-02-0212 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraRemix: Nick Weber, Shane Miller, and Jon Ferrara: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Remix: Nick Weber, Shane Miller, and Jon Ferrara”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahtt...
2022-01-2612 min
WeAreLATech Los Angeles Startups Podcast, hosted by Espree DevoraNick Weber of Papercast: WeAreLATech Startup SpotlightDon't miss out on the next WeAreLATech podcast episode, get notified by signing up here http://wearelatech.com/podcastWelcome to WeAreLATech's Los Angeles Tech Community Spotlight! “Nick Weber of Papercast.ai”WeAreLATech Podcast is a WeAreTech.fm production.To support our podcast go to http://wearelatech.com/believe To be featured on the podcast go to http://wearelatech.com/feature-your-la-startup/Want to be featured in the WeAreLATech Community? Create your profile here http://wearelatech.com/communityHost,Espree Devorahttps://twitter...
2022-01-2416 min
PapercastOlimpiadas Tokyo 2021 / Steam Deck, una nueva consola y algunas recomendaciones para ver desde casaAprovechando la semana de las Olimpiadas en Tokyo 2021, en Quienes somos para juzgar dejamos en telea de juicio algunos comportamientos de unos olimpos mexicanos que durante la presentación hicieron de las suyas. Además, la compañía y plataforma Steam ha dado a conocer su consola oficial. Tenemos también un par de recomendación para ver desde la comodidad de su casa. PaperCast, el podcast más chipocludo entra en sesión.
2021-07-261h 02
PapercastEpisodio 23. YosStop en prisión preventiva. El multiverso Loki. Un gran actor mexicano de la peor época del cine.En el episodio de hoy retomamos el caso de YosStop en Quienes somos para juzgar y hablamos de otros Youtubes/Influencer que tal vez debieran compartir el destino de la chica. También abordamos el multiverso de Loki y el impacto en el futuro de Universo Cinematográfico de Marvel.
Además, Alfonso Zayas ha muerto, un gran actor mexicano, representante del cine de ficheras, la peor época del cine.
2021-07-101h 15
PapercastEpisodio 22. El Bati Cunnilingus, Todo sobre la E3 y la Cobardía de MarvelEn este capitulo, DC censura episodios de la nueva serie de Batman donde se apreciaba un cunnilingus del cruzado hacía su, ahora, pareja Gatúbela. Además de que hablamos de los puntos más importantes de la E3 y todo lo que necesitas saber sobre los nuevos lanzamientos. Además, Marvel demuestra una cobardía en sus nuevas series de Disney +. Todo esto y más el PaperCast, el podcast más chipocludo de la web, episodio 22
2021-06-281h 21
PapercastEpisodio 21. Qué hay nuevo en streaming / Tercera edad ataca / Videojuegos y franquicias zombieEn el episodio 21 de PaperCast, el podcast más chipocludo, hacemos recomendaciones de series nuevas y divertidas en plataformas de streaming (Netflix, Amazon Prime Video, Disney+). También comentamos el resurgimiento de la tercera edad en el mundo del streaming. Los videojuegos zombies, ¿qué son? franquicias y videojuegos muertas que lograron revivir.
https://paperclipoficial.com/
2021-06-131h 03
PapercastEpisodio 20. El programa especial de Friends ¿necesario o no? / Noticias de cine / PaperCastEn el episodio 20 hablamos de algunas noticias importantes para el cine y las plataformas de streaming con la compra de Amazon a MGM y el mundo de películas que se avecinan. También vimos el especial de Friends, el encuentro y reunión tan esperado por todos los fans, pero ¿era realmente necesaria? Averígualo y comparte con tus amigos nuestro podcast, el más chipocludo de la web.
No olvides visitar nuestro sitio web oficial para más podcas, más noticias del cine y del mundo gaming: paperclipoficial.com
2021-06-011h 08
PapercastEpisodio 19. E-Sport FIFA 2021 y el previo a la reunión de FriendsEn el Episodio 19 de PaperCast, el podcast más chipocludo, se retoma la dinámica por secciones y abordamos los E-sports en México en el periodo de FIFA 2021. Además hablamos del próximo reencuentro de los actores de Friends e invitados especiales y hacemos un rondín por las caricaturas ochenteras que se intentan revivir en la actualidad.
2021-06-011h 05
PapercastEpisodio 18. 𝗦𝘁𝗮𝗿 𝗪𝗮𝗿𝘀, 𝙪𝙣 𝙚𝙨𝙥𝙚𝙘𝙞𝙖𝙡 𝙙𝙚 𝙈𝙖𝙮𝙤En el especial de Star Wars por el 4 de mayo, el Día de la Fuerza, PaperCast, el podcast con menos suerte del planeta sufre un ataque feroz del Imperio y corta la transmisión. Nuestros valientes guerreros luchan por recuperar reiniciar el En Vivo, y recuperar el orden de la señal perdida.
2021-05-121h 09
PapercastEpisodio 17. Entrega Premios Óscar / Películas que debieron ganarloEn el Episodio 17 hacemos un especial previo a la entrega de los premios Oscar 2021 y hacemos un breve recorrido por aquellas premiaciones que causaron polémica de una u otra forma en otros años.
2021-04-291h 22
PapercastEpisodio 16. El caso Tomiii 11Ivonne Grimm, Ghratos y Arkiathos se ponen un poquito serios analizan el caso Tomiii 11, desde la sorpresiva labor filantrópica de los usuarios de Internet hasta las posibles repercusiones emocionales para el youtuber... ¡antes de pasar a hablar de las PEORES parejas de tus series favoritas! (Nota especial: ¡Ross y Rachel estaban en un break!)
2021-04-151h 25
PapercastEpisodio 15. Películas que nadie pidióEn el episodio 15 de PaperCast, el podcast mejor escondido, nos zambullimos por aquellas películas que nadie pidió y que resultan en algo completamente innecesario. Además un par de anécdotas chuscas de nuestras visitas al cine. Así que, púchale play y acompáñanos en Papercast, tu podcast dominical.
2021-03-3057 minPapercastEpisodio 14. Zack Snyder's Justice League / ¿Cancelado?Celebrando el décimo cuarto capítulo de Papercast, Ghratos, Ivonne Grimm y Elimón Agrio estrenan formato hablando de funas y cancelaciones, de streaming y sus plataformas, de Snyder y Justice League. ¿Era una película necesaria? ¿Es Twitch la mejor plataforma? ¿Quiénes somos para juzgar? #PapercastReloaded
2021-03-221h 49
PapercastEpisodio 13. Únete a la Resistencia8M e IvoneeGrimm toma el control del set de Papercast con nuestras invitadas de lujo para hablar del papel de la mujer en el cine, los streaming, los videojuegos y la cultura pop. #PaperMorras it's here.
2021-03-081h 20
PapercastEpisodio 12. Fails, errores y algunos rencoresLa aventuras continuan con Ghratos, Arkiathos y Elimón Agrio en su camino por la vida, y en el episodio de hoy repasamos algunos de los más grandes fails de los videojuegos y algunas compañías, pasando por nuestros propios errores y algún que otro rencor por ahí.
2021-03-011h 09
PapercastEpisodio 11. Still a better love story than TwilightADVERTENCIA: Éste episodio fue BANEADO en Facebook a nivel mundial, ¡no podrás creer la razón!
¿Por qué nos encantan las películas románticas aunque sean tan malas? Averígualo en éste romántico episodio con nuestra invitada especial que DETESTA las películas de amor.
2021-02-161h 08
PapercastEpisodio 10. Manías, colecciones y otros pecados¿Tenemos manías como videojugadores? Claro que sí, coleccionar etiquetas de pantalones es una de ellas... (Yo que sé, pregúntenle a Aramis). Estos y más temas en el podcast de esta semana. Arkiathos nos acompaña desde el Switcher para reproducir vídeos que te invitamos a ver en nuestro canal de YouTube.
2021-02-091h 11
PapercastEpisodio 9. Team Godzilla vs. Team KongEn el Episodio 9 del podcast más chipocludo entre Rosario y Culiacán, Elimón Agrio se ha enfermado y depende de IvonneGrimm, Arkiathos y Ghratos definir el destino de la humanidad: Team Godzilla o Team Kong. Un viaje por el universo de los Monstruos y Kaijus más famosos del cine, la literatura y los videojuegos.
2021-02-0359 min
PaperCastA cosa serve il Make-up? - (feat. Elenoire Bernardi) - PaperCast! 1x14Molto spesso il mondo del make-up viene visto come un mondo superficiale basato su svariati stereotipi, non considerando i sacrifici e studi necessari che sono presenti all'interno di questo lavoro in continua crescita e sviluppo. Ma quindi a cosa serve il make-up? Essere una Make-Up Artist può essere un vero lavoro? Di questo e molto altro abbiamo parlato insieme a Elenoire Bernardi in questa quattordicesima puntata di PaperCast.
2021-01-2855 min
PaperCastOrmai non si può più scherzare su nulla - (feat. Mirko Darar) - PaperCast! 1x13Il mondo della stand-up comedy è estremamente variegato ed interessante. Passa dalla televisore generalista, ai grandi palchi teatrali fino ad arrivare ad internet. Oggi, di fronte a tutto questo, è davvero possibile pensare di vivere facendo questo lavoro? Di questo e molto altro abbiamo parlato insieme a Mirko Darar in questa tredicesima puntata di PaperCast.
2021-01-2846 min
PaperCastCome fare il modello secondo wikiHow - (feat. Eugenio Casnighi) - PaperCast! 1x12Gli stereotipi sul mondo dei modelli e delle modelle sono molti, ma sono tutti veri? I consigli che si ricevono per fare questo lavoro sono effettivamente validi o sono unicamente luoghi comuni? Di questo e molto altro abbiamo parlato insieme ad Eugenio in questa dodicesima puntata di PaperCast.
2021-01-2818 min
PaperCastQuanto lavoro c'è dietro ad un videoclip? - (feat. Davide Vicari) - PaperCast! 1x11Quanto lavoro c'è dietro un videoclip musicale? Come ci si approccia alla sua realizzazione e come si affrontano le difficoltà sul set? Di questo e molto altro abbiamo parlato insieme a Davide Vicari in questa undicesima puntata di PaperCast.
2021-01-281h 16
PaperCastA far canzoni non si fanno le rivoluzioni - (feat. Miriam Ayaba) - PaperCast! 1x10Combattere il razzismo, il sessismo e l'omofobia tramite la musica. Il mondo dei talent show e il futuro della musica in Italia. Di questo e molto altro abbiamo parlato con Miriam Ayaba in questa decima puntata di PaperCast.
2021-01-2846 min
PaperCastServe davvero studiare per diventare regista? - (feat. Nicola Bussei) - PaperCast! 1x09Per diventare regista è fondamentale frequentare una scuola di cinema o l'esperienza sul campo è sufficiente? Cosa differenzia un video-maker bravo da una persona "normale" che gira video? Per creare un contenuto di qualità basta avere buone competenze tecniche o serve dell'altro? Di questo e molto altro abbiamo parlato insieme a Nicola Bussei in questa nona puntata di PaperCast.
2021-01-2848 min
PaperCastSe dici Disney dici bello - (feat. I Nerdyland) - PaperCast! 1x08Anche Disney+ è arrivato finalmente in Italia ma, tutto ciò che produce è effettivamente di qualità? Essere un prodotto Disney significa automaticamente essere bello? Di questo e molto altro abbiamo parlato con i Nerdyland in questa ottava puntata di PaperCast.
2021-01-2827 min
PaperCastSe sei una persona di talento non hai bisogno del marketing - (feat. Tommy Kuti) - PaperCast! 1x07É vero che creare un contenuto è tanto importante quanto saperlo vendere? La scuola incentiva le persone creative o le opprime? Come può fare oggi un giovane artista ad emergere dal calderone del web? Di questo e molto altro abbiamo parlato con Tommy Kuti in questa settima puntata di PaperCast.
2021-01-281h 00
PaperCastNon puoi fare la moda se non abiti a Milano - (feat. Simone Tessadori) - PaperCast! 1x06Si dice che solo stando a Milano sia possibile sfondare nella moda. Simone Tessadori è l'esempio vivente che questo non è vero, anzi! Con lui abbiamo parlato di moda, stile e di come sia riuscito ad emergere fino ad arrivare su riviste come Vogue e Grazia. Di questo e molto altro abbiamo parlato in questa sesta puntata di PaperCast.
2021-01-2859 min
PaperCastSalviamo le povere ragazze con il velo - (feat. Aya - MilanPyramid) - PaperCast! 1x05Dal velo alla libertà di culto, per passare al terrorismo fino ad arrivare al ruolo della donna all'interno della religione islamica. Di questo e molto altro abbiamo parlato con Aya (milanpyramid) in questa quinta puntata di PaperCast.
2021-01-2852 min
PaperCastIl vero Hip Hop è quello di 30 anni fa - (feat. Willy.Vi) - PaperCast! 1x04Dall'Hip Hop più classico fino a passare a quello più contemporaneo, il mischiare i generi per creare qualcosa di nuovo fino ad arrivare alla determinazione per realizzare i propri sogni e dare valore al proprio talento. Di questo e molto altro abbiamo parlato con Willy.Vi in questa quarta puntata di PaperCast.
2021-01-2835 min
PaperCastFaccio Musica! Si ma di lavoro vero? - (feat. Jester Society) - PaperCast! 1x03Da Brescia fino a Londra, parlando di lavoro, sogni e musica! Di questo e molto altro abbiamo parlato con i Jester Society in questa terza puntata di PaperCast.
2021-01-2832 min
PaperCastSe sei famoso allora sei felice - (feat. Alessandro Magalini) - PaperCast! 1x02Può un sedicenne gestire tutte le conseguenze della fama? In cosa si stanno trasformando i Social Network? Popolarità è sinonimo di felicità? Di questo e molto altro abbiamo parlato con Alessandro Magalini in questa seconda puntata di PaperCast.
2021-01-281h 05
PaperCastNon fare la solita femminista dimm*rda - (feat. Emily Wolf) - PaperCast! 1x01Dal maschilismo al femminismo pop, per passare alle molestie fino al concetto di intersezionalità. Di questo e molto altro abbiamo parlato con Emily Wolf in questa prima puntata di PaperCast.
2021-01-2745 min
PapercastEpisodio 8. Secuelas Non GhratasToda gran saga tiene una secuela non grata. Franquicias que se vinieron abajo después de cierta película o series que perdieron su toque en tal o cual temporada. En este episodio hablamos de todas ellas. ¿Star Wars? ¿Terminator? ¿Friends? Ninguno se salva.
2021-01-261h 19
PapercastEpisodio 7. Juegos que repetimos una y otra y otra vez.Episodio sobre juegos que no podemos dejar de jugar por alguna extraña razón, la psicología gamer de Elimón y políticas públicas. ¿Qué demonios? Así somos en Papercast.
2021-01-111h 11
PapercastEpisodio 6. Lo MEJOR y lo PEOR del 2020Prepara tus botanas favoritas, pícale al play y acompáñanos a debatir todo aquello que nos mantuvo cuerdos en este pandémico año; con suerte y hasta encuentras buenas recomendaciones.
2020-12-291h 33
PapercastEpisodio 5. Películas Navideñas ¿Mejores y peores?En este episodio especial, nos ponemos los gorritos navideños para hablar de la mejor época del año: Navidad y para ello hacemos una lista de las mejores y peores películas. ¿Qué es mejor que la Navidad? Hablar de sus películas y series en Papercast ¡Acompáñanos y Feliz Navidad (adelantada)!
2020-12-171h 26
PapercastEpisodio 4. Del papel a la pantallaCómics, mangas y hasta novelas que ni dios conoce, en este cuarto 𝗲𝗽𝗶𝘀𝗼𝗱𝗶𝗼 𝗱𝗲 𝗣𝗮𝗽𝗲𝗿𝗖𝗮𝘀𝘁 hablamos de las adaptaciones a la pantalla grande (y chica). ¿Buenas, malas, 𝘥𝘪𝘰𝘴 𝘮í𝘰 𝘱𝘰𝘳 𝘲𝘶é 𝘩𝘪𝘤𝘪𝘴𝘵𝘦 𝘦𝘴𝘵𝘰 𝘺𝘢 𝘮𝘦𝘫𝘰𝘳 𝘮á𝘵𝘢𝘯𝘰𝘴? ¡Acompáñanos a discutirlo!
2020-12-091h 06
PapercastEpisodio 3. PC vs. ConsolasSabemos que cada semana esperan con ansias locas el podcast oficial de Paperclip, así que sin más preámbulos les dejamos con el tercer episodio "PC VS Consola" ¿Cuál es mejor?. Spoiler Alert: PC es mejor. ¡Toma eso, Aramis!
2020-12-091h 08
PapercastEpisodio 2. Cine MexicanoEl Cine Mexicano se puede clasificar históricamente en Época de Oro, Comedia Ranchera, Cine de Ficheras, Cine de Luchadores, Nuevo Cine Mexicano y... ¿Década del Pito de Oro? Descubre cuál es en éste segundo episodio de Papercast.
Si te preguntas por qué no empezamos con el Episodio 1 es porque en Papercast nos gusta Star Wars.
2020-12-091h 01
Road to Performance ScienceRTP Papercast #2 - Jordi VicensDespués del estreno de nuestros nuevos formatos os traemos aquí la segunda entrevista en formato Papercast, el formato de entrevista que nos ayuda a conocer de cerca el trabajo de investigación y divulgación que compañeros y compañeras están realizando en e ámbito deportivo.
En esta ocasión disfrutamos de un rato de charla con Jordi Vicens, investigador en la Universitat Central de Catalunya-Universitat de Vic y en el centro universitario EUSES Salt y preparador físico en el Club de Futbol Peralada.
Este episodio nos muestra una pequeña pincelada de todo el trabajo que Jordi e...
2020-11-0430 min
Road to Performance ScienceRTP Papercast #2 - Jordi VicensDespués del estreno de nuestros nuevos formatos os traemos aquí la segunda entrevista en formato Papercast, el formato de entrevista que nos ayuda a conocer de cerca el trabajo de investigación y divulgación que compañeros y compañeras están realizando en e ámbito deportivo.
En esta ocasión disfrutamos de un rato de charla con Jordi Vicens, investigador en la Universitat Central de Catalunya-Universitat de Vic y en el centro universitario EUSES Salt y preparador físico en el Club de Futbol Peralada.
Este episodio nos muestra una pequeña pincelada de todo el trabajo que Jordi e...
2020-11-0430 min
Road to Performance ScienceRTP Papercast #1 - Juanma YañezUna semana más seguimos de estreno de formato de contenidos en nuestra página web, y esta vez os traemos la primera publicación en formato Papercast. Este es una nueva idea que pretende ser un formato más breve que el Podcast, y a través del cual podamos conocer de primera mano el trabajo que realizan investigadores/as en el ámbito de las Ciencias del Deporte.
En este primer episodio de nuestro repertorio de Papercast entrevistamos a Juanma Yañez, Preparador Físico en los equipos de cantera de Betis Coosur e Investigador en el Centro de Investig...
2020-05-2523 min
Road to Performance ScienceRTP Papercast #1 - Juanma YañezUna semana más seguimos de estreno de formato de contenidos en nuestra página web, y esta vez os traemos la primera publicación en formato Papercast. Este es una nueva idea que pretende ser un formato más breve que el Podcast, y a través del cual podamos conocer de primera mano el trabajo que realizan investigadores/as en el ámbito de las Ciencias del Deporte.
En este primer episodio de nuestro repertorio de Papercast entrevistamos a Juanma Yañez, Preparador Físico en los equipos de cantera de Betis Coosur e Investigador en el Centro de Investig...
2020-05-2523 min