Shows
Discover CircResDiscover CircRes July 2025This month on Episode 74 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 20th and July 4th issues of Circulation Research. This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award. Article highlights: Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection Getaneh, et al. 2025-07-1741 minDiscover CircResDiscover CircRes June 2025This month on Episode 73 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research. This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. 2025-06-1937 minDiscover CircResDiscover CircRes May 2025This month on Episode 72 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research. This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF 2025-05-1534 minDiscover CircResDiscover CircRes April 2025This month on Episode 71 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the March 28th and April 11th issues of Circulation Research. This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice. 2025-04-1735 minDiscover CircResDiscover CircRes March 2025This month on Episode 70 of Discover CircRes, host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women. 2025-03-2033 minDiscover CircResDiscover CircRes February 2025This month on Episode 69 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research. This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology. Article highlights: Huang, et al. Vps4a Safeguards Plasma Membrane Integrity Liu, et al. 2025-02-2034 minDiscover CircResDiscover CircRes January 2025This month on Episode 68 of Discover CircRes, host Cindy St. Hilaire highlights four articles featured in the January 3rd and January 17th issues of Circulation Research. This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy. Article highlights: Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis 2025-01-1634 minDiscover CircResDiscover CircRes December 2024This month on Episode 67 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research. This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function. 2024-12-1926 minDiscover CircResDiscover CircRes November 2024This month on Episode 66 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the October 25th and November 8th issues of Circulation Research. This Episode also includes a discussion with Dr Jil Tardiff and Dr Melissa Lynn about their study, Arg92Leu-cTnT Alters the cTnC-cTnI Interface Disrupting PKA-Mediated Relaxation. Article highlights: Lou, et al. Visualizing irAEs in Atherosclerosis Yoshii, et al. 2024-11-2140 minDiscover CircResOctober 2024 Discover CircResThis month on Episode 65 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the September 27th and October 11th issues of Circulation Research. This Episode also includes a discussion with Dr Ken Walsh and Dr Ariel Polizio about their study, Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism. Article highlights: Ju, et al. NAE1 Crotonylation Regulates Cardiac Hypertrophy 2024-10-1738 minDiscover CircResSeptember 2024 Discover CircResThis month on Episode 64 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 30th and September 13th issues of Circulation Research. This Episode also includes a discussion with Drs Stephanie Chung, Ahmed Gharib, and Khalid Abd-Elmoniem from NIDDK about their study, Endothelial Dysfunction in Youth-Onset Diabetes Type 2, A Clinical Translational Study. Article highlights: Zhao, et al. AMPK Phosphorylation of β-Arresti2024-09-1934 minDiscover CircResAugust 2024 Discover CircResThis month on Episode 63 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the August 2nd and August 16th issues of Circulation Research. This Episode also includes a discussion with Drs Chen Gao and Yibin Wang about their study, Glucagon Receptor Antagonist for Heart Failure with Preserved Ejection Fraction Article highlights: Douvdevany, et al. Imaging the Turnover of the Sarcomere 2024-08-1533 minDiscover CircResJuly 2024 Discover CircResThis month on Episode 62 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the July 5th and July 19th issues of Circulation Research. This Episode also includes a discussion with the four finalists for the Basic Cardiovascular Sciences Outstanding Early Career Investigator Award. Article highlights: Mallaredy, et al. Extracellular Vesicle Red2024-07-1845 minDiscover CircResJune 2024 Discover CircResThis month on Episode 61 of Discover CircRes, host Cindy St. Hilaire highlights articles featured in the June 7th and June 21st issues of Circulation Research. This Episode also includes a discussion with Dr Chris O'Callaghan and Jiahao Jiang from the University of Oxford about their study, A Novel Macrophage Subpopulation Conveys Increased Genetic Risk of Coronary Artery Disease. Article highlights: 2024-06-2027 minDiscover CircResMay 2024 Discover CircResThis month on Episode 60 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the May 10 and May 24th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Astrof and Dr AnnJosette Ramirez from Rutgers University about their study, Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease. Article highlights: Tamiato, et al. Pericyte RGS5 in Cardiac Aging Zifkos, et al. PTP1B and Venous Thromboinflammat2024-05-1636 minDiscover CircResApril 2024 Discover CircResThis month on Episode 59 of Discover CircRes, host Cindy St. Hilaire highlights original research articles featured in the April 12 and April 26th issues of Circulation Research. This Episode also includes a discussion with Dr Craig Morrell and Chen Li from University of Rochester about their study, Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function. Article highlights: Arkelius, et al. LOX-1 and MMP-9 Inhibition Improves Stroke Outcomes Cruz, et al. C122Y Disrupts Kir2.1-PIP22024-04-1831 minDiscover CircResMarch 2024 Discover CircResThis month on Episode 58 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 1 and March 15th issues of Circulation Research. This Episode also includes a discussion with Drs Frank Faraci, Tami Martino, and Martin Young about their contributions to the Compendium on Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease2024-03-2140 minDiscover CircResFebruary 2024 Discover CircResThis month on Episode 57 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the February 2nd and February 19th issues of Circulation Research. This Episode also includes a discussion with Dr Kathryn Howe and Dr Sneha Raju from University of Toronto, about their manuscript titled Directional Endothelial Communication by Polarized Extracellular Vesicle Release2024-02-1535 minDiscover CircResJanuary 2024 Discover CircResThis month on Episode 56 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the January 5th and January 19th issues of Circulation Research. This Episode also includes a discussion with Dr Julie Freed and Gopika Senthilkumar from the Medical College of Wisconsin about their study, Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease. 2024-01-1830 minDiscover CircResDecember 2023 Discover CircResThis month on Episode 55 of Discover CircRes, host Cynthia St. Hilaireaire highlights two original research articles featured in the December 8th issue of Circulation Research. This Episode also includes a discussion with Dr José Luis de la Pompa and Dr Luis Luna-Zurita from the National Center for Cardiovascular Research in Spain about their study, Cooperative Response to Endocardial NOTCH Reveals Interaction With Hippo Pathway. Article highlights: 2023-12-2128 minDiscover CircResNovember 2023 Discover CircResThis month on Episode 54 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the October 27th and November 10th issues of Circulation Research. This Episode also includes a discussion with Dr Sophie Susen and Dr Caterina Casari about their study, Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia, published in the October 27th issue. 2023-11-1626 minDiscover CircResOctober 2023 Discover CircResThis month on Episode 53 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the September 29th and October 13th issues of Circulation Research. This Episode also includes a discussion with Dr Margaret Schwarz and Dr Dushani Ranasinghe about their study, Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension, published in the September 29 issue. 2023-10-1928 minDiscover CircResSeptember 2023 Discover CircResThis month on Episode 52 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the September 1 and September 15th issues of Circulation Research. This Episode also includes a discussion with Dr Manuel Mayr about the study, Proteomic Atlas of Atherosclerosis, the Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes and Outcomes, published in the September 15 issue. 2023-09-2132 minDiscover CircResAugust 2023 Discover CircResThis month on Episode 51 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 4th and August 18th issues of Circulation Research. This Episode also includes a discussion with Dr Eric Small and Dr Xiaoyi Liu from the University of Rochester Medical Center about their article p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricular Pressure Overload, published in the July 21st issue of the journal. 2023-08-1731 minDiscover CircResJuly 2023 Discover CircResThis month on Episode 50 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the June 23, July 7, and July 21 issues of Circulation Research. This Episode also includes a discussion with BCVS Outstanding Early Career Investigator Award Qiongxin Wang from University of Washington St. Louis, Haobo Li from Massachusetts General Hospital, and Asma Boukhalfa from Tufts Medical Center. Article highlights: Tong, et al. The Role of DRP1 in Mitophagy Abe, et al. ERK5-NRF2 Axis and Senescence-Associated Stemness Dai, et al. Therapeutic Targeting of Endocytosis Defects in DCM...2023-07-2034 minDiscover CircResJune 2023 Discover CircResThis month on Episode 49 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the May 26th issue and provides an overview of the June 9th Compendium on Early Cardiovascular Disease of Circulation Research. This Episode also includes a discussion with Dr Tejasvi Dudiki and Dr Tatiana Byzova about their study, Mechanism of Tumor Platelet Communications in Cancer. Article highlights: Nichtová, et al. Mitochondria-SR Tethering and Cardiac Remodeling Ferrucci, et al. Muscle Transcriptomic and Proteomic in PAD Compendium on Early Cardiovascular Disease.2023-06-1526 minDiscover CircResMay 2023 Discover CircResThis month on Episode 48 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the April 28th issue of Circulation Research. This Episode also includes a discussion between Dr Mina Chung, Dr DeLisa Fairweather and Dr Milka Koupenova, who all contributed to manuscripts to the May 12th Compendium on Covid-19 and the Cardiovascular System. Article highlights: Heijman, et al. Mechanisms of Enhanced SK-Channel Current in AF Chen, et al. IL-37 Attenuates Platelet Activation Enzan, et al. ZBP1 Protects Against Myocardi...2023-05-1836 minDiscover CircResApril 2023 Discover CircResThis month on Episode 47 of Discover CircRes, host Cynthia St. Hilaire highlights three original research articles featured in the March 31 issue of Circulation Research. We’ll also provide an overview of the Compendium on Increased Risk of Cardiovascular Complications in Chronic Kidney Disease published in the April 14 issue. Finally, this episode features an interview with Dr Elizabeth Tarling and Dr Bethan Clifford from UCLA regarding their study, RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Article highlights: Shi, et al. LncRNAs Regulate SMC Phenotypic Transition Chen, et al...2023-04-2034 minDiscover CircResMarch 2023 Discover CircResThis month on Episode 46 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 3 and March 17th issues of Circulation Research. This episode also features an interview with Dr Andrew Hughes and Dr Jessilyn Dunn about their review, Wearable Devices in Cardiovascular Medicine. Article highlights: Delgobo, et al. Deep Phenotyping Heart-Specific Tregs Sun, et al. Inhibition of Fap Promotes Cardiac Repair After MI Sun, et al. Endosomal PI3Kγ Regulates Hypoxia Sensing Johnson, et al...2023-03-1634 minDiscover CircResFebruary 2023 Discover CircResThis month on Episode 45 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the February 3rd and February 17th issues of Circulation Research. This episode also features an interview with Dr Hind Lal and Dr Tousif Sultan from the University of Alabama at Birmingham about their study Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation. Article highlights: Pi, et al. Metabolomic Signatures in PAH Carnevale, et al. Thrombosis TLR4-Mediated in SARS-CoV-2 Infection Cai, et al...2023-02-1630 minDiscover CircResJanuary 2023 Discover CircResThis month on Episode 44 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the January 6th and January 20th issue of Circulation Research. This episode also features an interview with Dr Timothy McKinsey and Dr Marcello Rubino about their study, Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. Article highlights: Prasad, et al. ACE2 in Gut Integrity and Diabetic Retinopathy Cui, et al. Epsins Regulate Lipid Metabolism and Transport Li, et al. Endothelial H2S modulates EndoMT in H...2023-01-1930 minDiscover CircResDecember 2022 Discover CircResThis month on Episode 43 of Discover CircRes, guest host Nicole Purcell highlights two original research articles featured in the December 2 issue of Circulation Research. This episode also features an interview with Drs Aaron Phillips and Kevin O'Gallagher about their study, The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans. Article highlights: Akerberg, et al. RBPMS2 Regulates RNA Splicing in Cardiomyocytes Lv, et al. Cardiac Protection by MG53-S255A Mutant Nicole Purcell: Hi and welcome to Discover CircRes, the podcast of...2022-12-1523 minDiscover CircResNovember 2022 Discover Circ ResThis month on Episode 42 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the October 28 and November 11th issues of Circulation Research. This episode also features an interview with Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson from University of California San Diego about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformations. Article highlights: Jia, et al. Prohibitin2 Maintains VSMC Contractile Phenotype Rammah, et al. PPARg and Non-Canonical NOTCH Signaling in the OFT Wang, et al. H...2022-11-1728 minDiscover CircResOctober 2022 Discover Circ ResThis month on Episode 41 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 30 and October 14 issues of Circulation Research. This episode also features an interview with Dr Kory Lavine and Dr Chieh-Yu Lin from Washington University St. Louis, to discuss their study, Transcriptional and Immune Landscape of Cardiac Sarcoidosis. Article highlights: Tian, et al. EV-Mediated Heart Brain Communication in CHF Wleklinski, et al. Impaired Dynamic SR Ca Buffering Causes AD-CPVT2 Masson, et al. Orai1 Inhibition as a Tre...2022-10-2029 minDiscover CircResSeptember 2022 Discover Circ ResThis month on Episode 40 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 2 and September 16 issues of the journal. This episode also features an interview with Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, from the City University of New York, about their study, Interaction of ARRDC-4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart. Article highlights: Jin, et al. Gut Dysbiosis Promotes Preeclampsia Mengozzi, et al. SIRT1 in Human Microvascular Dysfunction Hu, et al. Racial Diff...2022-09-1528 minDiscover CircResAugust 2022 Discover CircResThis month on Episode 39 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 5th and 19th issues of the journal. This episode also features an interview with Dr Annet Kirabo and Dr Ashley Pitzer from Vanderbilt University on their article, Dendritic Cell ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. Article highlights: Jain, et al. Role of UPR in Platelets Orlich et al: SRF Function in Mural Cells of the CNS Xue et al: Gut Microbial IPA Inhi...2022-08-1832 minDiscover CircResJuly 2022 Discover Circ ResThis month on Episode 38 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the Jue 24th, July 8th and July 22nd issues of the journal. This episode also features an interview with the 2022 BCBS Outstanding Early Career Investigator Award finalists, Dr Hisayuki Hashimoto, Dr Matthew DeBerge and Dr Anja Karlstadt. Article highlights: Nguyen, et al. miR-223 in Atherosclerosis. Choi, et al. Mechanism for Piezo1-Mediated Lymphatic Sprouting Kamtchum-Tatuene, et al. Plasma Interleukin-6 and High-Risk Carotid Plaques Li...2022-07-2138 minDiscover CircResJune 2022 Discover Circ ResThis month on Episode 37 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the May 27th issue of the journal and also provides an overview of the Compendium on Basic Models of Cardiovascular Disease featured in the June 10 issue of Circulation Research. This episode also features an interview between Dr Nikki Purcell, Circulation Research Social Media Editor and Associate Professor at Huntington Medical Research Institute and Dr Mark Feinberg, Dr Rulin Zhuang, and Dr Jingshu Chen from Brigham and Women's Hospital in Harvard Medical School to discuss their study, Perivascular Fibrosis Is Mediated by...2022-06-1626 minDiscover CircResMay 2022 Discover Circ ResThis month on Episode 36 of Discover CircRes, host Cynthia St. Hilaire highlights original research articles featured in the April 29 and May 13 issues of Circulation Research. This episode also features a conversation with Dr Patricia Nguyen and Jessica D'Addabbo from Stanford University about their study, Human Coronary Plaque T-cells are Clonal and Cross-React to Virus and Self. Article highlights: Zanoli, et al. COVID-19 and Vascular Aging Wang, et al. JP2NT Gene Therapy in a Mouse Heart Failure Mode Harraz, et al. Piezo1 Is a Mechanosensor in C...2022-05-1930 minDiscover CircResApril 2022 Discover Circ ResThis month on Episode 35 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the April 1 issue of Circulation Research, as well as highlights from the Stroke and Neurocognitive Impairment Compendium in the April 15th issue. This episode also features a conversation with Dr Shubing Chen and Dr Yuling Han from Weill Cornell Medical College to discuss their study, SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Article highlights: Pabel, et al. Effects of Atrial Fibrillation on the Ventricle Pattarabanjird, et al. P62-Mediated B1b...2022-04-2126 minDiscover CircResMarch 2022 Discover CircResThis month on Episode 34 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the March 4 and March 18th issues of Circulation Research. This episode also features a conversation with Dr Mireille Ouimet and Sabrina Robichaud from the University of Ottawa Heart Institute to discuss their study, Autophagy is Differentially Regulated in Leukocyte and Non-Leukocyte Foam Cells During Atherosclerosis. Article highlights: Pauza, et al. GLP1R in CB Suppress Chemoreflex-Mediated SNA Lim, et al. IL11 in Marfan Syndrome Hohl, et a...2022-03-1731 minDiscover CircResFebruary 2022 Discover Circ ResThis month on Episode 33 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the February 4 issue of Circulation Research. In addition, she previews Circulation Research’s Compendium on Women and Cardiovascular Health, featured in the February 18th issue. This episode also features a conversation with Dr Alastair Poole and Dr Laura Corbin from the University of Bristol and Dr Stephen White from the Manchester Metropolitan University about their study, Epigenetic Regulation of F2RL3 Associates with Myocardial Infarction and Platelet Function. Article highlights: Samargandy, et al. Bloo...2022-02-1726 minDiscover CircResJanuary 2022 Discover CircResThis month on Episode 32 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the January 7 and January 21 issues of Circulation Research. This episode also features a conversation with Ms Natalie Harris and Dr Kathleen Caron from the University of North Carolina Chapel Hill about their study, VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling. Article highlights: Carlson, et al. AKAP18δ Controls CaMKIIδ Activity Gan, et al. sEV and Adipocyte ER Stress Following MI/R Khan, et al. Long-term Risk Predic...2022-01-2028 minDiscover CircResDecember 2021 Discover CircResThis month on Episode 31 of Discover CircRes, host Cynthia St. Hilaire highlights two original research articles featured in the December 3 issue of Circulation Research. This episode also features a conversation with Drs Xavier Revelo, and Jop van Berlo from the University of Minnesota about their study, Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis. Article highlights: Tong, et al. Alternative Mitophagy Protects Obesity Hearts Soetkamp, et al. Myofilament Phosphorylation in CDC Treated HFpEF Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the Ameri...2021-12-1622 minDiscover CircResNovember 2021 Discover CircResThis month on Episode 30 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the October 29 and November 12 issues of Circulation Research. This episode also features a conversation with Dr Elisa Klein from the University of Maryland about her study, Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity. Article highlights: Subramani, et al. CMA of eNOS in Ischemia-Reperfusion Liu, et al. Macrophage MST1 Regulates Cardiac Repair Van Beusecum, et al. GAS6/Axl Signaling in Hypertension Pati, et al. Exosomes Pr...2021-11-1827 minDiscover CircResOctober 2021 Discover CircResThis month on Episode 29 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 17th and October 1st issues of Circulation Research. This episode also features conversations with BCVS Outstanding Early Career Investigator Award finalists, Dr Jiangbin Wu from the University of Rochester, Dr Chen Gao from UCLA, and Dr Chris Toepfer from Oxford University. Article highlights: Raftrey, et al. Dach1 Extends Arteries and Is Cardioprotective Zhang, et al. Blood Inflammatory Exosomes and Stroke Outcome Joyce, et al. Cardiovascular Heal...2021-10-2130 minDiscover CircResSeptember 2021 Discover CircResThis month on Episode 28 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the August 20th and September 3rd issues of Circulation Research. This episode also features an in-depth conversation with Dr Scott Cameron from the Cleveland Clinic and Dr Milka Koupenova from the University of Massachusetts Medical Center about their study, SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Article highlights: Gupta, et al. Electronic Cigarettes and Oxidized Lipids Bartosova, et al. Glucose Derivative Induced Vasculopathy in CKD Atmanli, et al...2021-09-1631 minDiscover CircResAugust 2021 Discover CircResThis month on Episode 27 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the July 23rd and August 6th issues of Circulation Research. This episode also features an in-depth conversation with Drs Ana Gomez and John Pierre Benitah, from INSERM and the Paris-Saclay University, about their study, Impaired Binding to Junctophilin 2 and Nanostructural Alterations in CPVT Mutation. Article highlights: Glasenap, et al. Imaging Inflammation and Fibrosis in Heart Failure Shi, et al. Cardiomyocyte Pyroptosis Aggravates MI/R Injury Koenis, et al...2021-08-1926 minDiscover CircResJuly 2021 Discover CircResThis month on Episode 26 of Discover CircRes, host Cindy St. Hilaire highlights four original research articles featured in the June 25th and July 9th issues of Circulation Research. This episode also features an in-depth conversation with Dr Hirofumi Watanabe, Dr Ariel Gomez, and Dr Maria Luisa Sequeira-Lopez from the University of Virginia about their study, The Renin Cell Baroreceptor, A Nuclear Mechanotransducer Central for Homeostasis. Article highlights: Mesirca, et al. Electrical Remodeling of the AV Node in Athletes Yang, et al. Macrophage-Mediated Inflammation in COVID-19 Heart Ör...2021-07-1528 minDiscover CircResJune 2021 Discover CircResThis month on Episode 25 of Discover CircRes, host Cindy St. Hilaire highlights the topics covered in the June 11th Compendium on Peripheral Vascular Disease, as well as discussing two original research articles from the May 28th issue of Circulation Research. This episode also features an in-depth conversation with Drs Eric Small and Ryan Burke from the University of Rochester Medical Center about their study Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Article highlights: Ghosh, et al. IAP Overexpression Attenuates Atherosclerosis Dörr, et al. Etelcalcetide for Cardiac Hype...2021-06-1727 minDiscover CircResMay 2021 Discover CircResThis month on Episode 24 of Discover CircRes, host Cindy St. Hilaire highlights the topics covered in the May 14th Compendium on Heart Failure, as well as discussing two original research articles and a brief overview of the Review Series on Calcific Aortic Valve Disease from the April 30th issue of Circulation Research. This episode also features an in-depth conversation with Dr David Durgan and Huanan Shi from Baylor School of Medicine about their study Restructuring The Gut Microbiota by Intermittent Fasting Lowers Blood Pressure. Article highlights: Vacante, et al. CARMN Regulates Atherosclerosis via SM...2021-05-2027 minDiscover CircResApril 2021 Discover CircResThis month on Episode 23 of Discover CircRes, host Cindy St. Hilaire highlights the topics covered in the April 2nd Compendium on Hypertension issue, as well as discussing two articles from the April 16 issue of Circulation Research. This episode also features an in-depth conversation with Dr Kathryn Moore from the New York University School of Medicine, discussing her study, miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques. Article highlights: Compendium on Hypertension Mustroph, et al. CASK Regulates Excitation-Contraction Coupling Ward, et al. NAA15 Haploinsufficiency and...2021-04-1529 minDiscover CircResMarch 2021 Discover CircResThis month on Episode 22 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the March 5 and March 19 issues of Circulation Research. This episode also features an in-depth conversation with Norberto Gonzalez-Juarbe and Maryann Platt from the J. Craig Venter Institute to discuss their study, Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence. Article highlights: Carnicer, et al. BH4 Prevents and Reverses Diabetic LV Dysfunction Kyryachenko, et al. Regulatory Profiles of Mitral Valve Mangner, et al. Heart Failure Associated Diaphragm Dysfunction 2021-03-1826 minDiscover CircResFebruary 2021 Discover CircResThis month on Episode 21 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the February 2 and February 19 issues of Circulation Research. This episode also features an in-depth conversation with Konstantinos Drosatos and Ioannis Kyriazis from Temple University to discuss their study, KLF5 is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Article highlights: Wittenbecher, et al. Lipidomics and Heart Failure Risk Kryshtal, et al. Flecainide Directly Inhibits RYR2 Ca Release Chen, et al. Klotho and Heart Aging 2021-02-1825 minDiscover CircResJanuary 2021 Discover CircResThis month on Episode 20 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the January 8 and January 22 issue of Circulation Research. This episode features an in-depth conversation with Drs Stefanie Dimmeler and Wesley Abplanalp from Goethe University in Frankfurt, Germany, regarding their study titled Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure. Article highlights: Li, et al. FA Scaffold Genes Are Novel TAA Genes Z Perestrelo, et al. ECM Structure and Mechanics in Heart Failure Castranova, et al...2021-01-2128 minDiscover CircResDecember 2020 Discover CircResThis month on Episode 19 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the December 4 issue of Circulation Research. This episode features an in-depth conversation with Drs Mete Civelek and Redouane Aherrahrou, from the University of Virginia regarding their study titled Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. Article highlights: Zahreddine, et al. Tamoxifen and E2 Effects On Reendothelialization Zheng, et al. Arterial Stiffness Preceding Diabetes Galang, et al. ATAC-seq Identifies Novel Isl1 SAN Enhancer Cin...2020-12-1726 minDiscover CircResNovember 2020 Discover CircResThis month on Episode 18 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the October 23 and November 6 issues of Circulation Research. This episode features an in-depth conversation with Drs Eric Boilard from the Université Laval in Quebec, Canada, and Fadila Guessous from Mohammed VI University of Health Sciences in Casablanca, Morocco regarding their study titled Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19. Article highlights: Feng , et al. No Contribution of EMPs to Endothelium Lin, et al. Step Count and Predicted CVD...2020-11-1936 min
Discover CircResOctober 2020 Discover CircResThis month on Episode 17 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the September 25 and October 9 issues of Circulation Research. This episode features an in-depth conversation with Drs David Dichek, Sina Gharib and Tomáš Vaisar regarding their study titled Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture. Article highlights: Cai, et al. Single Cell RNA-Seq in Arteriosclerosis Schuhmann, et al. CD84 in Ischemic Stroke VanOudenhove, et al. Gene Regulatory Dynamics of Developing Human Heart Nie, et al. Periostin is a Target to Treat PH Dr Cindy St...2020-10-1532 min
Discover CircResSeptember 2020 Discover CircResThis month on Episode 16 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the August 28 and September 11 issues of Circulation Research. This episode features an in-depth conversation with Drs Andrew Murphy and Michelle Flynn from The Baker Heart and Diabetes Institute at Monash University in Melbourne, Australia regarding their study Transient Intermittent Hyperglycemia Accelerates Atherosclerosis By Promoting Myelopoiesis. Article highlights: Fish, et al. KRAS Mutations Cause Arteriovenous Malformations Ehling, et al. B55a in Vascular Biology Barrett, et al. Platelet Activ...2020-09-1724 min
Discover CircResAugust 2020 Discover CircResThis month on Episode 15 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the July 31 and August 14 issues of Circulation Research. This episode features an in-depth conversation with Drs Venu Venna and Juneyoung Lee from the Department of Neurology at the McGovern Medical School at the University of Texas Health Science Center at Houston regarding their study Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice. This episode also includes a brief discussion with BCVS Outstanding Early Career Investigator Award competition finalists, Drs Shyam Bansal from Ohio State University, Emmanouil Tampakakis from...2020-08-2032 min
Discover CircResJuly 2020 Discover CircResThis month on Episode 14 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the July 3 and July 17 issues of Circulation Research. This episode also features an in-depth conversation with Dr. Brenda Ogle and Drs. Molly Kupfer and Wei-Han Lin regarding their study, In Situ Expansion, Differentiation and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid. Article highlights: Wei, et al. Palmitoylation Cycling and Endothelial Maturity van Ouwerkerk, et al. Functional Variant Elements in Atrial Fibrillation Models 2020-07-1621 min
Discover CircResJune 2020 Discover Circ ResThis month on Episode 13 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the June 5 issue of Circulation Research and gives listeners an inside scoop on the cutting-edge ideas in the June 19th Compendium on Atrial Fibrillation. This episode also features an in-depth conversation with Dr David McManus on emerging technologies for identifying AFib. Article highlights: Zhang, et al. ACEI/ARB on COVID-19 in patients with hypertension Sakamoto, et al. ERR Signaling and Cardiac Maturation Xie, et al. CIRP Governs the Heart Rate Response to...2020-06-1827 min
Discover CircResMay 2020 Discover CircResThis month on Episode 12 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the May 8 issue of Circulation Research and gives listeners an inside scoop of the cutting edge ideas in the May 22nd Compendium on Obesity. This episode also features an in-depth conversation with Dr Eduardo Marbán concerning COVID-19 and its effects on the heart. Article highlights: Roberts et al. LYN Regulates Monocyte Heterogeneity and Lifespan Lu, et al. Acute Hyperglycemia Activates CaMKII-ROS Pathway Yan, et al. Epicardium and Atrial Cardiomyopathy Tr...2020-05-2129 minDiscover CircResApril 2020 CircRes This month on Episode 111 of the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from the March 27 issue of Circulation Research and talks with Dr. Matthias Nahrendorf and Dr. Maximilian Schloss about their article Modifiable Cardiovascular Risk, Hematopoiesis and Innate Immunity. Article highlights: Liu et al. Genetics of Transposition of the Great Arteries Park et al. Mild Lipid Abnormalities and ASCVD in the Young Yan, et al. Gut Flora Adjusts Blood Pressure By Corticosterone Transcript Cindy St. H...2020-04-2325 min
Discover CircResMarch 2020 Discover CircRes This month on Episode 10 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the February 28 and March 13, 2020 issues of Circulation Research and talks with Dr Mary McDermott about her article Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The Cocoa-Pad Pilot Randomized Clinical Trial. Article highlights: Rykaczewska, et al. PCSK6 Is a Key Protease in Vascular Injury Lebek, et al. SDB Induces Arrhythmias via CaMKII and Late Ina Mueller, et al. Brain Damag...2020-03-1921 min
Discover CircResFebruary 2020 Discover CircResThis month on Episode 9 of the Discover CircRes podcast, host Cindy St. Hilaire highlights four featured articles from the January 31 and February 14, 2020 issues of Circulation Research and talks with Dr Joe Miano and DrThomas Quertermous about their article Coronary Disease-Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway. Article highlights: Wang, et al. Multi-Omics Integration Study of AF Heianza, et al. Antibiotics and Risk of Mortality Dikalova, et al. Sirt3 Reduces Hypertension and Vascular Dysfunction Hu, e...2020-02-2026 min
Discover CircResJanuary 2020 Discover CircResThis month on Episode 8 of the Discover CircRes podcast, host Cindy St. Hilaire speaks with Nikki Purcell and Sean Wu, the chair and vice-chair of the BCVS Early Career Committee. The episode also features an interview with the 2019 BCVS Early Career Finalists, Dr Luigi Adamo, Dr Swati Dey, and Dr Jihoon Nah. In addition, we highlight three featured articles from the January 3 and January 17, 2020 issues of Circulation Research. Article highlights: Souza, et al. Upregulation of Plasma SPM by Enriched Marine Oils Paredes, et al. Metabolic Control of VSMC...2020-01-1634 min
Discover CircResDecember 2019 Discover CircResThis month on Episode 7 of the Discover CircRes podcast, host Cindy St. Hilaire highlights two featured articles from the December 6, 2019 issue of Circulation Research and talks with Roy Silverstein and Yiliang Chen about their article, Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Article highlights: McArdle, et al, et al. Migratory and Dancing Atherosclerotic Macrophages Skaria, et al. Cardioprotection with Endogenous αCGRP Transcript Dr Cindy St. Hilaire: Hi, welcome to Discover CircRes the monthly podcast of the American Heart Association journal, Circulation Research. I'm your host, Dr C...2019-12-1229 min
Discover CircResNovember 2019 Discover CircResThis month on Episode 6 of the Discover CircRes podcast, host Cindy St. Hilaire highlights five featured articles from the October 25 and November 8, 2019 issues of Circulation Research and talks with Coleen McNamara and Aditi Upadhye about their article, Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis. Article highlights: Omura, et al. ADAMTS8 in Pulmonary Hypertension. Rödel, et al. Blood Flow Suppresses CCM Phenotypes in Zebrafish Cai, et al. Proteomics Asses...2019-11-1427 min
Discover CircResOctober 2019 Discover CircRes This month on Episode 5 of the Discover CircRes podcast, host Cindy St. Hilaire highlights five featured articles from the September 27 and October 11, 2019 issues of Circulation Research and talks with Sarvesh Chelvanambi and Matthias Clauss about their article HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients. Article highlights: Stamatelopoulos, et al. Reactive Vasodilation in AL Amyloidosis Cao, et al. Miro2-Mediated Cardiac Mitochondrial Communication Georgakis, et al. Circulating MCP-1 Levels and Incident Stroke 2019-10-1729 min
Discover CircResSeptember 2019 IssueThis month on the Discover CircRes podcast, host Cindy St. Hilaire highlights five featured articles from recent issues of Circulation Research and talks with Matthew Stratton, Rushita Bagchi, and Tim McKinsey about their article on Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Article highlights: Vincentz, et al. HAND1 Enhancer Variation Impacts Heart Conduction Zhuang, et al. EC-Klf2-Foxp1-Nlrp3 Regulates Atherogenesis Quintanilla, et al. Robust Targets for Persistent AF Ablation Lambert et al. Characterization of Kcnk3-Mutated Rats Myagmar et a...2019-09-1936 min
Discover CircResAugust 2019 Issue This month on the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from recent issues of Circulation Research and talks with Denisa Wagner and Nicoletta Sorvillo about their article on how PAD4 in blood promotes VWF strings and thrombosis. Article highlights: Goodyer et al: ScRNA-seq of the Cardiac Conduction System Xiong et al: Chemotaxis Mediated Second Heart Field Deployment Ranchoux et al: Pulmonary Hypertension and Metabolic Syndrome Rühl et al. Thrombin/APC Response in FVL and FII 20210G>A 2019-08-1531 min
Discover CircResJuly 2019 Discover CircResThis month on the Discover CircRes podcast, host Cindy St. Hilaire highlights three featured articles from recent issues of Circulation Research and talks with Steve Lim and James M. Murphy about their article on nuclear FAK regulation of smooth muscle cell proliferation. Article highlights: Li et al: Histone Turnover in Adult Heart Kurosawa et al: Celastramycin Ameliorates Pulmonary Hypertension Urban et al: NOS3 Gene Polymorphism and Coronary Heart Disease Transcript Cindy S.: Hi, welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal, Circulation Research. I'm your host Cindy S...2019-07-1826 min
Discover CircResDiscover CircRes Intro PodcastCindy S.H.: Hi. Welcome to Discover CircRes, the monthly podcast of the American Heart Association's journal Circulation Research. I'm your host, Cindy St. Hilaire, and my goal is to bring you highlights of articles published in the Circ Research Journal as well as have in-depth conversations with senior scientists and the junior trainees who have led the most exciting discoveries in our current issues. Today is our premier episode, so I want to take some time to introduce myself, give you a little bit of background about the history of the journal, and then have a conversation with our ne...2019-06-2032 min