Shows
DMPK InsightsDMPK Insights #12: New Frontiers in Understanding the BBB Transport of Small Molecule DrugsFor a captioned version or to access the transcript, please visit: https://www.pharmaron.com/knowledge-center/dmpk-insights-12-bbb-transporters/In this podcast, Elena and Mikko will discuss the current state-of-the-art around transporter sub-types and their expression within the blood-brain barrier (BBB) and opportunities for utilizing these transporters for brain drug delivery. We will address the following questions: Current knowledge of BBB transporters in health and disease Approaches to utilize BBB transporters for brain drug delivery What to consider while developing transporter-mediated drug delivery systems to the brain Future development (anticipated and required) to further the field...2025-04-2438 min
DMPK InsightsDMPK Insights #11: Drug Meets Bug: How the Gut Microbiome Shapes DMPKFor a captioned version or to access the transcript, please visit https://www.pharmaron.com/knowledge-center/dmpk-podcast-11-gut-microbiome/.In this podcast, Chris Bode (Pharmaron US Labs) interviews Peter Turnbaugh, a microbiologist and Professor of Microbiology and Immunology at the University of California San Francisco. Over the past 15-20 years, Peter has produced so much groundbreaking research in the endlessly fascinating field of the gut microbiome. His work is not limited to DMPK by any means, but in this episode, we discuss drug metabolism by gut bacteria and its impact on pharmacokinetics. Clinically, reduced efficacy and/or increased...2025-03-1847 min
DMPK InsightsDMPK Insights #10: The DMPK Project Representative: An essential role of contribution, integration and evolutionIn this podcast Simon Taylor (Pharmaron UK) interviews Kevin Beaumont, a highly experienced DMPK scientist, leader and drug developer who has lived and breathed the role of the DMPK Project Representative throughout his 40-year industrial career. With experience of delivering clinical drug candidates across multiple therapeutic areas with two major pharma companies (Pfizer and AstraZeneca) Kevin describes his entry into the role, the value of people, in roles as mentee and mentor, and the shift in emphasis of DMPK from a discipline supporting drug development to one driving drug discovery. Covering key concepts related to project DMPK and minimising dr...2025-01-1547 min
DMPK InsightsDMPK Insights #9: 60 and Beyond: Navigating the Frontiers of PBPK and QSPIn this podcast, listeners will join us in celebrating the remarkable career of Professor Amin Rostami, a trailblazer in the realms of PBPK and QSP. Following his 60th birthday, Professor Rostami will provide insights into his journey, the dynamic evolution of PBPK and QSP, and the exciting horizons ahead. Tune in for a deep dive into the intersections of academia and industry, technological advancements, and the invaluable lessons garnered throughout a pioneering career.The episode explores the following:The key milestones and highlights of Professor Amin's career in PBPK and QSPThe factors that initially captivated his...2024-08-1239 min
DMPK InsightsDMPK Insights #8: It’s “All-go” with Oligos: Challenges and Opportunities in LC-MS of TherapeuticIn this podcast, Robert MacNeill, Professor Michael Bartlett of the University of Georgia and Dr. Guilherme Guimaraes of Biogen, will focus on oligonucleotide LC-MS covering the exciting key challenges, the pivotal nature of sensitivity in such assays, and the various analytical approaches and technologies that have been used, currently in use or being developed. The episode explores the following:How recent liquid chromatographic and mass spectral innovations have impacted the bioanalysis of these drug modalitiesWhere innovation is taking us particularly in terms of the increasing profile of high-resolution mass spectrometry and the push toward chromatographic miniaturization2024-07-0827 min
DMPK InsightsDMPK Insights #7: Carboxylic Acids and DILI – Conjugation and ReputationIn this podcast, Professor Ian Wilson, a globally recognised and leading expert in drug metabolism, with over 500 publications in the field, takes us on an engaging journey exploring the link between carboxylic acid containing drugs and their involvement in DILI. A special focus will be given to Ian’s latest paper: ‘Minimizing the DILI potential of carboxylic acid-containing drugs: a perspective’.The episode explores the following:Are acyl glucuronides shouldering too much of the blame?Where else should we be looking?What are the possible risk mitigation strategies to reduce DILI with these chemotypes?Spea...2024-05-1033 min
DMPK InsightsDMPK Insights #6: Protein Mass Spectrometry: Advancing the Bioanalysis of Biotherapeutics and BiomarkersIn this podcast, Scott and John will discuss the LC-MS techniques that have been applied for the bioanalysis of biotherapeutics.The episode explores the following:The impact that mass spectrometry is having in the biotherapeutics and biomarker spaceThe rationale behind the use of LC-MS for certain biomarkers and how sensitive LC-MS assays can be developed (and the practical limits for lower limits of quantification that can be achieved)Developments in mass spectrometry that are expected to benefit the analysis of biomarkers and for biotherapeuticsSpeaker:...2024-03-0639 min
DMPK InsightsDMPK Insights #4: DMPK Past, Present and Future – A Festive TaleThis podcast format is inspired by the Charles Dicken’s novella “A Christmas Carol” whereby Phil Jeffrey (Bicycle Therapeutics), Beth Williamson (UCB) and Daniel Price (Nimbus) discuss DMPK Past, Present and Future with Scott. Key elements discussed include the evolution of DMPK as a predictive discipline that links helps the chemistry of drug design with the biology of drug disposition and effect.The episode addresses the following questions:The founding names and principles of DMPK and the emergence of Discovery DMPKToday’s use of technologies and in silico modelling and DMPK’s role in the 3 pillars/5Rs and PK/P...2023-12-141h 03
DMPK InsightsDMPK Insights #5: Mass Spectrometry Imaging - Past, Present and FutureIn this podcast, Josephine Bunch, Principal Research Scientist and Co-Director of the National Centre of Excellence in Mass Spectrometry (NiCE-MSI) at NPL, talks about her work, and in particular her involvement in the Cancer Research UK Grand Challenge Programme. The episode explores the following:Recent innovations in MSI Challenges associated with analyzing ever more complex moleculesLabel-free vs labelled imagingHardware and software improvements and how these affect the industryCombining imaging techniques to extract maximum informationExciting developments for the future, including personalized medicine and the innovative technologies that will make this a realitySpeaker:Josephine Bun...2023-09-2130 min
DMPK InsightsDMPK Insights #3: Free Drug Theory: No Longer Just a Hypothesis?In this podcast, Scott Summerfield, Senior Director, Pharmaceutical Metabolism at Pharmaron discusses his recent publication on Free Drug Theory (FDT) with Simon including the principles, arguments, and project impact. This article was an invited contribution to a special edition of the Pharmaceutical Research Journal recognizing the achievements of Professor Margareta Hammarlund-Udenaes and Kp,uu.The episode addresses the following questions:What is the FDT?How FDT relates to fundamental physical and biochemical principles?How ambiguity in its definition can hamper discussions in drug design?Importance of linking drug-at-target concentrations to drug-target bindingHow to apply FDT as...2023-09-1836 min
DMPK InsightsDMPK Insights #2: Pathways to Successful Drug Design – Discovery Metabolite IDIn this podcast, Dan Weston, Scientific Leader, Biotransformation at GSK discusses his recent publication on the important role that Metabolite ID plays in drug discovery.The episode addresses the following questions:Why studying biotransformation is an important part of early drug design A strategy to combine in silico tools, high-resolution MS and software-assisted data analysis to optimize data delivery and qualityHow this influences medicinal chemistry and the design–make–test cycleSpeaker:Dan Weston, Ph.D. - Scientific Leader, Biotransformation at GSKDan gained his Ph.D. in ion-trap mass spectr...2023-09-1726 min
DMPK InsightsDMPK Insights #1: Candidate Survival – 3 Pillars to 5Rs and BeyondIn this podcast, Dr. Paul Morgan, Head of DMPK at Grünenthal Group, discusses the development of the publication that introduced the “5R framework” and improved the likelihood of AstraZeneca candidate survival from candidate drug nomination to Phase III. We will then discuss how the area has developed since then and where the field may go in the future.The episode addresses the following questions:What was the situation like that led to the development of the 5Rs?How was the analysis conducted?How was this analysis accepted both within the organization and externally?What changes occur...2023-09-1245 min
Pathways Podcast - Warwick ChemistryS3-E3: Applying for and Succeeding on PlacementsIn this episode, Tom speaks to Jess and Harriet Cruikshank about their experiences on their third-year placements. Jess completed her placement with Rolls Royce over the summer, while Harriet is on a 12-month placement with Pharmaron, which she is completing alongside her studies. They discuss the process of application, the work-life balance, and the skills they have learned, and how they have brought them back to their work in the department. A transcript for this episode is here.2022-10-1420 min