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万物生长FM从代谢、激素、表观遗传…聊聊为什么人到中年爱发福？E.128可能很多人都能感觉到，随着年龄的增长，发福的速度要比年轻时候快得多，而且需要更多的运动和饮食控制才能维持和年轻时候差不多的减肥效果。这一期，我们想聊聊人到“中年”（宽口径的中年）爱发福中的科学线索，我们可能会聊到，人的代谢会随着年龄的增长而下降，这是真的吗？男女肌肉含量的差异，对于发福有哪些影响？我们的体型和体重，受激素的影响有多大？为什么中年的肥胖喜欢出现在腰上？以及还会聊到，表观遗传可能帮助你的体重“上大分”等等内容……内容时间轴：2:50 很多人说，中年发福是由代谢变化导致的，这是真的吗？6:04 孕妇每日消耗是不是一个成人加婴儿的能量总和？8:04 实验中的每日消耗是怎么测的？12:10 运动对人体最核心的改变是什么？16:38 男女脂肪分布差异及其生理原因19:30 人体脂肪的分类，及不同脂肪的功能22:45 “脂肪细胞总体数量不变，只有大小的变化”，这是真的吗？27:43 长期随访研究揭示脂肪细胞与体重变化的关联30:03 激素对肥胖的影响与性别差异32:50 年龄增长、瘦素抵抗与腹部脂肪堆积的机制探讨36:02 中年腹部脂肪增生与新生脂肪细胞研究39:00 中年小鼠脂肪细胞互换实验及新药研发41:08 表观遗传学与肥胖的关系探讨44:24 “肥胖会引起一定程度的持续免疫反应和炎症反应”，是真的吗？#song list Cello Suite No. 1 in G Major, BWV 1007:I. Prélude - Janos Starker Love From Me-Johnson Rodgie Study With Me - Snuggles Mark Masri - Santa Lucia听友群加VX：hooley777商务合作：allthingsgrowing@qq.com#参考资料： Pontzer H, Yamada Y, Sagayama H, et al. Daily energy expenditure through the human life course. Science. 2021;373(6556):808-812. doi:10.1126/science.abe5017 Yen Chin Koay, Kelly Stanton, Vivian Kienzle, Mengbo Li, Jean Yang, David S Celermajer, John F O’Sullivan, Effect of chronic exercise in healthy young male adults: a metabolomic analysis, Cardiovascular Research, Volume 117, Issue 2, 1 February 2021, Pages 613–622 Elia, M. (1992). Organ and tissue contribution to metabolic rate. Kinney JM, Tucker HN, Energy metabolism: tissue determinants and cellular corollaries. Raven Press199261–80. Janssen I, Heymsfield SB, Wang ZM, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr [published correction appears in J Appl Physiol (1985). 2014 May 15;116(10):1342]. J Appl Physiol (1985). 2000;89(1):81-88. doi:10.1152/jappl.2000.89.1.81 Blaak E. Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care. 2001;4(6):499-502. doi:10.1097/00075197-200111000-00006 Nguyen TT, Corvera S. Adipose tissue as a linchpin of organismal ageing. Nat Metab. 2024;6(5):793-807. doi:10.1038/s42255-024-01046-3 Arner P, Bernard...2025-05-1349 min
Sydney IdeasGreening healthcareCan we save lives and save the planet? Hear how the healthcare sector is tracking, finding solutions and making changes, to be more sustainable and green.
Healthcare is both significantly affected by, and is a contributor to, climate change. If the global health sector were a country, it would be the fifth largest emitter of greenhouse gases in the world.
So, how can Australia work towards a more sustainable healthcare system, without compromising on quality and safety?
Hear from cardiologist David Celermajer, sustainability researcher Amanda Irwin and global public health professional Rashmi Venkatraman – with host and science communicator Dr Naomi Ko...2023-08-2948 min
Reimagined FuturesEpisode 1: What are climate imaginaries?How can we so clearly understand the gravity of the climate crisis and what needs to be done and yet still not be acting fast enough? What gets in the way of all of us being part of making the change, or pushing for the changes that need to be made? In the opening episode of the Reimagined Futures series, Professor Danielle Celermajer reveals the barriers that are halting systemic change and the possibilities for transformative collective action.
Delve into the series more and explore our show notes here: https://tinyurl.com/5x9bwxas
Credits2023-03-0127 min
The SEI Podcast SeriesReimagining Environmental Responsibility After the State of the Environment ReportIn response to the dire findings of the recent State of the Environment Report, this panel will explore the political, economic and ideological constraints that got us here, and the ways forward to ensure meaningful environmental protection.Timestamps00:52 Introduction – David Schlosberg07:35 Environmental Legislation and How we Got to this Current State of the Environment – Gerry Bates13:48 What is the Government’s Relationship with Civil Society? - David Morris19:46 What are the Economic Interests, Ideologies and Institutions that Have Brought us to this Current Situation? – Frank Stilwell 27:52 Ethical Frameworks and Principles Underpinning Biodiversity Concerns – Danielle Celermajer 33:30 Possible Responses and Solutions to the Curren...2022-08-3057 min
From The Heart: The HeartKids PodcastCommon Cardiac Procedures... Professor David CelermajerECGs, chest x-rays, blood tests, ultrasounds, exercise tests, CT scans, MRI scans and catheters. If you have a childhood heart condition, you have likely encountered some or all of these tests before. Professor David Celermajer is one of the top adult cardiologists in Australia and the world. In this episode, he explains what each of these tests are, what's involved in getting them, why cardiologists use them, and the importance of regular check-ups. HEARTKIDSFrom The Heart is brought to you by HeartKids, the only national not-for-profit solely focused on supporting and advocating for pe...2022-07-3035 min
The SEI Podcast SeriesRedefining Who Matters: Institutionalising Multi-species JusticeIn a time of environmental crisis and heightened social and political tension, a panel of SEI experts call for institutionalising justice for all species through key areas of innovation such as international laws on ecocide and the expansion of personhood beyond humans. For more information about this event click here Timestamps 00:50 Introduction - Danielle Celermajer 02:35 The Current Context and Radical Politics 08:55 Ecuador and the Rights of Nature - Erin Fitz-Henry 19:40 Wild Law Judgments and Multispecies Justice - Nicole Rogers 34:10 The Expansion of Legal Personhood and...2022-07-051h 01
Freedom of SpeciesKate Hall, Xenotransplantation and Dystopian FictionAdam and Davita are joined by the wonderful author Kate Hall. Kate is currently working on a dystopian novel around xenotransplantation. She provides a powerful critique of the practice of using animal-to-human transplants. She also introduces us to her protagonist Mouse by reading a few vivid excerpts from her novel in progress. Kate's published novel Kate Hazel Hall - From Darkness: https://www.katehazelhall.com/books Kate's recommendations for animal focused books: Laura Jean McKay - The Animals in That Country Eva Hornung - Dog Boy Karen Joy Fowler - We're All Completely Besides Ourselves Merlinda Bobis - Locust Girl Danielle Celerm...2021-09-1200 min
The SEI Podcast SeriesQuestions of Management and Policy Amidst Australia’s Bushfire CrisisAn interdisciplinary panel considers how government and industry should best respond to climate-related disasters, which will only become increasingly common, intense, widespread and destructive as the planet warms. The current state and federal approaches to disaster management are failing, as there are inadequate laws and policies to fund government agencies and compensate victims, especially where they are uninsured. With the government defunding research and ignoring recommendations on disasters, resilience and adaptation planning, is a community-based, collaborative approach the only way forward? For more information about this event click here. Timestamps 00:00 Introductions and Welcome to...2020-03-021h 25
Ideas at the HouseFuture Thinking - The Bushfire Catastrophe: What Now?Session 2: Future Thinking As the scale of the loss and devastation continues to mount, our communities have pulled together, and our politics and policies have been called into question. But the biggest question of all is, what do we do now? Is this a turning point in our nation's history? Hosted by Lenore Taylor, editor of The Guardian Australia with Oliver Costello, John Connor, David Bowman, Danielle Celermajer and Lenore Taylor. Hosted on Acast. See acast.com/privacy for more information.2020-02-181h 32
The SEI Podcast SeriesViolence in Plain SightHumans seem to agree on few ethical principles, but one that seems to be near universal is that unless it serves the ultimate purpose of peace, violence ought to be condemned. In this recording, SEI hosted an interdisciplinary panel on 'Violence in Plain Sight' with visiting scholar Professor Kari Marie Norgaard, that explored the reality of violence in research, the mechanisms of denial and invisibility, and the institutional realities that ensure the persistence of concealment. For more information about this event click here.Timestamps 00:00 Introduction - David Schlosberg 01:53 Welcome to Country - Yv...2019-12-101h 48
The SEI Podcast SeriesBeyond the Climate Elephant: From Climate Denial to Public EngagementClimate change inaction and climate change denial are serious issues, and indeed, a well-organised counter-movement has challenged the science on climate change, and thus the role of science as the basis for guiding public policy (literal denial). Alongside the serious threat to democracy posed by the phenomenon of “literal denial” is “implicatory denial” a phenomenon which occurs when people fail to integrate the facts about climate change that they believe to be true, in their decision-making, political activities, or sense of daily reality. From a sociological standpoint, this brings up interesting questions on human social behaviour surrounding climate change. How and...2017-11-301h 01
On The Wards: On The Pods Medical Podcast for DoctorsAtrial fibrillationJames talks to Professor David Celermajer on managing atrial fibrillation on the wards.
Editor: James Edwards
Interviewee: David Celemajer
About David Celemajer
Professor David Celermajer is the Scandrett Professor of Cardiology at The University of Sydney, Director of Echocardiography in the Cardiology Department as well as Director of Adult Congenital Heart Services, at Royal Prince Alfred Hospital. He has been Group Leader of the Clinical Research Group of the Heart Research Institute since 1994, and in 2003 was appointed as Clinical Director of the Heart Research Institute. He gained his Fellowship of the Australian Academy of Science in 2006 and graduated with First Cl...2014-09-1632 min