Shows
To Immunity and BeyondApoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosisProfessor Quentin Sattentau discusses research published in 'Nature Communications' on the role of enzyme ADAM10 in mediating clearance of apoptotic T cells by macrophages. This episode discusses Drexhage, LZ, Zhang, S, Dupont, M, et al. Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. Nat Commun. 15(1), 541 (2024). http://doi.org/10.1038/s41467-023-44619-8
Article funding and acknowledgments: https://www.nature.com/articles/s41467-023-44619-8#Ack1
Professor Sattentau thanks Linnea Drexhage and Shengpan Zhang (joint first authors) who worked really hard and provided most of the data, Niloofar Karaji who discovered the initial phenomenon, all the other...2024-11-0635 min
Collecting COVID: Oral HistoriesDr Rebecca MooreGeorgina Ferry interviews Rebecca Moore, former Postdoctoral Researcher and Laboratory Manager, 9 March 2022. Topics discussed include (00:01:03) RM's early interest in science and studies in biological sciences, microbiology and virology at Warwick University, work at Imperial College with HIV and blood processing for viral load, Wellcome Trust Funded PhD on adenoviral vector development for gene therapy, work in the U.S.A. undertaking post-doctoral studies on HIV, work at Oxford with Quentin Sattentau; (00:05:43) interest in laboratory work, including HIV vaccine design, work with students and teaching; (00:07:45) Containment Level III Laboratories and safety measures for working with live viruses; (00:11:22) RM's first memory of...2022-11-021h 05