Shows
科技前緣💉 跨越絕望的科學：全球首場兒童個人化 mRNA 癌症疫苗試驗啟動📝 摘要 (Summary)
本集節目將帶您深入探討澳洲啟動的一項世界首創臨床試驗：「PaedNEO-VAX」。
這項試驗由昆士蘭大學（UQ）領銜，結合先進的 mRNA 技術 與 全基因組定序，為患有侵襲性、復發性或抗藥性腦瘤的兒童量身打造「專屬疫苗」。除了技術面的解析，我們更將分享一個令人動容的幕後故事——Providence Therapeutics 創辦人 Brad Sorenson 如何在救子心切的絕望中創立公司，並讓他的兒子成為全球首位受益者。這不僅是醫學的突破，更是無數家庭在黑暗中的一線曙光。
📌 關鍵點 (Keypoints)
🇦🇺 全球首創 PaedNEO-VAX 試驗：澳洲政府注資超過 250 萬澳幣，在全國 8 家頂尖兒童醫院同步展開，針對復發性惡性腦瘤進行個人化疫苗測試。
🧬 10 週打造「量身定制」疫苗：透過全基因組定序識別每位病童腫瘤特有的「遺傳標記」，僅需約 10 週即可生產出專屬 mRNA 疫苗，精準訓練免疫系統攻擊癌細胞。
🧠 挑戰最難治的腦瘤：試驗涵蓋高惡性度膠質瘤（GBM）、髓母細胞瘤、室管膜瘤及瀰漫性中線膠質瘤（DMG）等多種難治病症。
❤️ 一位父親的使命：創辦人 Brad Sorenson 在兒子 Adam 被診斷出腦癌後拒絕放棄，他開發的疫苗不僅讓 Adam 重返校園，更成為這場全球試驗的技術基石。
🌍 國際合作的醫療新格局：該試驗以澳洲為起點，未來計畫將此「個人化製造模式」推廣至加拿大、美國及全球各地。
📚 參考文獻 (References)
核心研究報導：The University of Queensland, 2026/02/03, "Australian trial of personalised vaccines to treat children with deadly brain cancers."
企業官方公告：Providence Therapeutics Holdings Inc, 2026/02/04, "World-First Personalized Pediatric mRNA Cancer Vaccine Trial."
機構新聞：SAHMRI, 2026/02/04, "Children’s brain cancer vaccine trial."
訪談紀錄：iHeartRadio, 2026/01/07, "Shiftheads - When Your Kid Gets Cancer: Brad Sorenson's Story."
💬 聲明稿 (Disclaimer)
本頻道所有內容均為個人觀點與分析，不代表我現任或曾任職公司的立場。所有資訊均來自公開管道，不涉及任何內部或機密資訊。
(Disclaimer: The views and opinions expressed on this channel are my own and do not represent those of my employer. All information is based on publicly available sources.)
🏷️ 標籤 (Hashtags)
#科技前緣 #mRNA疫苗 #癌症治療 #個人化醫療 #兒童健康 #生醫科技 #腦瘤研究 #醫學突破 #澳洲科技 #PaedNEO-VAX #精準醫療 #Podcast
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A Window On SAHMRIDefying Dementia | Dr Andrew ShoubridgeDr Andrew Shoubridge is an early career postdoctoral researcher in microbiology and neurobiology. He was also awarded the honour of becoming SAHMRI's inaugural BRIGHT Accelerator and is currently using some of the funds raised by the community during the 2022 BRIGHT Walk to conduct a unique dementia research project.
2023-07-0428 min
A Window On SAHMRIEnding Endometriosis | Dr Joel CastroFor the 1 in 10 women who live with endometriosis, the pain can be excruciating and relentless.
All too often, endometriosis has life-changing consequences, with 50% of cases leaving women infertile. Surgery is the only way to remove the painful abdominal growths, but they often return and need further operations.
Dr Joel Castro is the Head of Endometriosis Research in SAHMRI's Visceral Pain Group and his team is determined to find non-invasive ways to control the pain and drastically reduce the symptoms of endometriosis.
It's a personal crusade for Joel, who has multiple family members living with the disease.
2023-05-3024 min
A Window On SAHMRILeukaemia Leader | Dr Elyse PageDr Elyse Page is a post-doctoral researcher with the leukaemia research group at SAHMRI.
Her research centres on investigating new driver genes and finding novel therapies for children with acute lymphoblastic leukaemia (ALL).
Experiencing her father's blood cancer journey set Elyse on the path to becoming the researcher she is today.
2023-05-0122 min
A Window On SAHMRIImproving The Lives of Older Australians | Associate Professor Gill CaugheyAssociate Professor Gill Caughey is Associate Director of the Registry of Senior Australians (ROSA) at SAHMRI.
Gill is a pharmacoepidemiologist, a mother of two and a leader of the next generation of aged care researchers.
2023-04-0324 min
A Window On SAHMRIBuilding A Brighter Future in Aboriginal Health | Tina BrodieTina Brodie is a Research Fellow in the Aboriginal Health Equity theme at SAHMRI and she's on the cusp of completing her PhD.
Tina's an Aboriginal woman with connections to the Yawarrawarrka / Yandruwandha, whose traditional lands lie within the Cooper Basin. Her research focuses on enhancing the social and emotional wellbeing of Aboriginal and Torres Strait Islander people. Tina grew up around racism and prejudice and is driven by the desire to create a better world for her two children and the Indigenous population of Australia.
2023-02-2824 min
A Window On SAHMRICancer Care Crusader | Dr Hannah WardillDr Hannah Wardill is an early career researcher on a mission to prevent the long-term physical, emotional and economic disadvantages of cancer.
Her work revolves around better understanding the side effects of cancer therapy to improve the wellbeing of people living with and beyond cancer.
She also likes collecting butterflies and she was briefly the top female 3-point shooter in Australia when she played basketball as a teenager!
2023-02-0331 min
A Window On SAHMRISolving Spinal Cord Injury | Dr Ryan O'Hare DoigDr Ryan O'Hare Doig, Group Leader of the Neil Sachse Centre for Spinal Cord Injury Research at SAHMRI.
Ryan’s research focuses on bettering scientific understanding of spinal cord injury and developing treatments for those living with SCI.
He's also an avid cyclist.
2022-11-1431 min
A Window On SAHMRIAcute Lymphoblastic Leukaemia Legend | Dr Laura EadieDr Laura Eadie is an award-winning biomedical researcher and the Peter Nelson Leukaemia Research Fellow in SAHMRI's Precision Cancer Medicine Theme.
Laura’s research seeks to pave the way for alternative Acute Lymphoblastic Leukaemia (ALL) therapies that are more effective and have fewer long-term side effects.
She's also presented a Ted Talk advocating for government to support research funding and she's out to debunk the stereotype that scientists aren't fun!
2022-11-1427 min
A Window On SAHMRIConnecting Communities | Eugene WarriorEugene Warrior is the Senior Engagement and Knowledge Broker within the Aboriginal Health Equity Theme at SAHMRI.
His work is all about connecting the Aboriginal and Torres Strait Islander community to research and services, ultimately helping to close the gap between Indigenous and non-Indigenous health.
Eugene was born and raised in Adelaide’s north and finds deep meaning and purpose in working to serve the people he knows personally.
He's also a footy enthusiast who can be found coaching at his local club when he's not at work or with his young family.
2022-10-3126 min
A Window On SAHMRIFor Mums & Bubs | Dr Karen BestDr Karen Best is the new Director of SAHMRI Clinical Trials Platform.
Karen's dedicated her career to caring for women and babies, first as a midwife and then as a researcher, playing a major role in developing the world-first omega-3 supplementation program for pregnant women in Adelaide, South Australia.
She's a mother herself and takes every opportunity to promote health for mums.
2022-09-2028 min
A Window On SAHMRIHealthy Ageing Hero | Dr Tim SargeantDr Tim Sargeant is Head of the Lysosomal Health in Ageing Group within SAHMRI's Lifelong Health Theme.
His research is dedicated to helping people live stronger for longer and his team recently invented a world-first blood test to measure healthy ageing in humans.
Tim's also a husband and young father of two with a burning passion to leave a better world for his children and a penchant for astronomy.
2022-09-2026 min
Life StoriesAlexandraA chat with Alexandra Emerson (Cook) about all sorts of things, but mainly her experience with infertility and premature birth, and how faith works in her life. Alexandra is walking 50km in 10 days during September for SAHMRI (South Australian Health and Medical Research Institute) to raise funds for research into preterm babies, her son Darcy having been born 6 weeks early. If you'd like to sponsor her walk, here is a link:https://my.sahmribright.org.au/alexandra-emerson
2021-09-181h 01
Making & Breaking Social PolicyA Model of Care - Aboriginal Prisoner Health in South Australia with Luke CantleyIn this episode, Luke Cantley, Research Associate with SWIRLS at Flinders Uni, talks us through the Model of Care for Aboriginal Prisoner Health and Wellbeing in South Australia. His experiences as a researcher and practitioner in the South Australian Prison systems demonstrate how social policy makes and breaks human service practice (and vice versa).
Follow Luke on Twitter: @luke_cantley
The Model of Care for Aboriginal Prisoner Health and Wellbeing in South Australia by the Wardliparingga Aboriginal Research Unit in the South Australian Health and Medical Research Institute (SAHMRI) can be accessed here: https://www...
2021-07-2357 min
Little Black Book: The Entrepreneur's PodcastThe CEO “Chief Eating Officer” - Greg Hobby – Taylor & Holmes Fine Food CateringGreg Hobby is one of the owners and CEO of Taylor & Holmes. Founded by Greg’s wife Kate, Taylor & Holmes are a fine food catering company that has expanded into cafes and restaurants, with locations at SAHMRI, Flinders Medical Centre and the Bridgewater Mill. Watch the full episode on YouTube here.
2021-03-2442 min
WavelengthTrump v Biden - who will win? A look at the 2020 US election (2 November, 2020)With the announcement of who will win America’s presidential election not far, we try to make sense of the political climate and whether there’s any truth to claims made by Trump about voter fraud. If Biden wins, will Trump actually refuse to leave the White House? Dr David Smith from the United States Studies Centre at the University of Sydney shares his insight into the election and the tactics being used by both nominees. To get the perspective of someone who’s lived in the US, dual-citizen Harrison joined us to share his view of both presidents and wh...
2020-11-0346 min
Auscast WellbeingCurious about you state of mind? Special guest Matthew Iasiello - The Mental Health Show with Mark AistonAre you a little curious about you state of mind? Well Matthew Iasiello has been involved in a brand new online program, that is here top help. Matthew is a researcher at the Wellbeing and Resilience Centre, Lifelong Health, at SAHMRI in South Australia. And he's been behind the research and development of this powerful tool. See omnystudio.com/listener for privacy information.
2020-09-2226 minThe Mental Health ShowCurious about you state of mind? Special guest Matthew Iasiello - The Mental Health Show with Mark AistonAre you a little curious about you state of mind? Well Matthew Iasiello has been involved in a brand new online program, that is here top help. Matthew is a researcher at the Wellbeing and Resilience Centre, Lifelong Health, at SAHMRI in South Australia. And he's been behind the research and development of this powerful tool. See omnystudio.com/listener for privacy information.
2020-09-2226 min
Insights from Industry LeadersSteve Wesselingh - Executive Director at SAHMRIProfessor Steve Wesselingh is the inaugural Chief Executive Officer at the National Health and Medical Research Council (NHMRC) and is the former Executive Director of the South Australian Health and Medical Research Institute (SAHMRI).
Ccentric is a market-leading executive search firm in Australia with an exclusive focus on healthcare, academic healthcare, digital health, and not-for-profit and human services – industries that improve the quality of life. Ccentric provides leadership solutions for clients with ranging from mid-level leadership to c-suite executive search, interim management, leadership assessment and succession planning.
Visit ccentric.com.au
2020-09-1510 min
Our State - South Australia03/08/20 - 146 - Smoking and COVID-19The global COVID-19 pandemic is having a profound effect on the lives of people all over the world. Current evidence suggests that smoking is significantly associated with increased severity of the virus if contracted. There has never been a better time to quit smoking for good and there is help available in SA to achieve this goal. Clinton Cenko, Manager Tobacco Control Unit at DASSA, and Dr Jacquie Bowden, Deputy Director of the Health Policy Centre SAHMRI, discuss this issue on this week's Our State.
2020-08-0227 min
The Uni Verse PodcastPostgraduate? Spark a New Path!This week Peta chats to PhD student Ashleigh Geiger about her undergraduate music studies, and how that led her to a Master of Philosophy in Medical Science! Find out more about her experience on trying something new and uncovering a new passion. Note: SAHMRI is the South Australian Health and Medical Research Institute See omnystudio.com/listener for privacy information.
2020-06-2114 min
Young Blood - Men’s Mental HealthClosing the Gap On Indigenous Health | Stephen HarfieldStephen Harfield dropped into the studio to break down the issues surrounding indigenous health.
He’s spent his career so far working to improve access to health services for indigenous people and close the gap between indigenous and non-indigenous rates of mental and physical illness.
Stephen has been a researcher at the Health Department of SA Aboriginal Health Division and is currently a Research Fellow at the Wardliparingga Aboriginal Research Unit at SAHMRI.
He has some insightful points to make about the impact of racism on health and tells the story of how his experience of growing up shaped his pa...
2019-09-2552 min
Aboriginal WayLester Irabinna Rigney On Children's Voices In TreatyOn today's program, we speak to Professor Lester Irabinna Rigney after a forum held at SAHMRI on the theme of this year's NAIDOC Week - Voice Treaty Truth.
Professor Rigney is a researcher who is investigating the rights of the child, looking at different ways we can improve the disparities between Aboriginal Children and non-Aboriginal Children. He says that Australia has 'educational amnesia' and that we urgently need to develop a culturally responsive schooling that recognises the knowledge and intelligence that all children bring to school.
He argues that Aboriginal children should have a direct voice in the development of...
2019-07-1815 min
Your Life Designed - Learn, Grow, Develop and Design Your Life - With Laura Carrocci82 - Sitting still and owning up to the BS you tell yourselfSo 3 weeks in a leg brace ...
If you know me you have probably heard me say, "you would have to strap me to a bed and sedate me in order to stop me walking and training every day."
What has come up in the last few weeks is all the fear underneath the constant moving that I tend to do.
Sure I meditate (at 4am before I get up and start moving), I contemplate (while I hike or swim), I sit down to eat (most of the time).
But I have know for a very long time that I have...
2019-05-2124 minYour Life Designed Podcast - Learn, Grow, Develop and Design Your Life - With Laura Carrocci82 - Sitting still and owning up to the BS you tell yourselfSo 3 weeks in a leg brace ...
If you know me you have probably heard me say, "you would have to strap me to a bed and sedate me in order to stop me walking and training every day."
What has come up in the last few weeks is all the fear underneath the constant moving that I tend to do.
Sure I meditate (at 4am before I get up and start moving), I contemplate (while I hike or swim), I sit down to eat (most of the time).
But I have know for a very long time that I have...
2019-05-2124 min
Making Positive Psychology WorkCan You Help A System Flourish? with Gabrielle KellyGabrielle Kelly is the SAHMRI Wellbeing and Resilience Centre's inaugural director. Gabe is a filmmaker, digital media executive, social entrepreneur and strategist, who has worked on human behaviour and systems change in a range of settings, including the groundbreaking Adelaide Thinkers in Residence Programme, where she commissioned and led the residency of professor Martin Seligman in South Australia in an effort to build mental wellbeing and resilience and reduce mental illness at a societal level. In this conversation, Gabe takes us inside the amazing work being done across the state of South Australia to help an entire p...
2017-11-2332 min
The Adelaide Show090 - Of spinal cords and stem cellsTonight we dive deep into health issues. Firstly, spinal cord imaging research at SAHMRI being undertaken with support of the Neil Sachse Foundation. Neil joins us along with key participants Professor Brian Freeman and Prab Takhar. Secondly, we meet local woman and mum, Ainsley Machonicie who has lived with MS for many years but is now embarking on a stem cell process to halt the disease and possibly reverse it. In Time To Think, George Inglis, reflects on SAHMRI - an organisation he LOVES with a passion. In IS IT NEWS, Nigel...
2015-05-131h 34
The Adelaide Show044 - Healthy Adelaide via SAHMRICould our Adelaide winter be a blessing for getting healthy? Professor Gary Wittert from the University of Adelaide thinks so and explains why as we talk to him about all manner of health topics as part of the SAHMRI opening. The South Australian Health and Medical Research Institute is celebrating its official opening this week and we chat with Gary about: The SAHMRI The Fat vs Sugar Q and A involving Tony Jones this week Whether South Australia should use indulgent food in its tourism advertising, given a growing awareness about cutting...
2014-06-261h 19