Shows
Sinapsos Podcast | OncologyTreatment Patterns in Lung Cancer Brain MetastasisE18 | 14 min | Latest | Publication Source
Podcast based on: Mobley JM, Phillips KI, Chen Q, Reusch E, Reddy N, Magsam JB, McLouth LE, Huang B, Villano JL. Outcomes of Brain Metastasis from Lung Cancer. Cancers. 2025; 17(2):256. https://doi.org/10.3390/cancers17020256
Type: Article | Publication date: Jan 14, 2025
Summary: This study investigated treatment patterns in 284 Kentucky lung cancer patients with brain metastases, focusing on the 21.8% who received no treatment. Researchers analysed factors influencing treatment decisions, including social history (tobacco use proved statistically significant), disease burden, and access to oncology care. The high incidence of lung cancer in Kentucky provided a relevant con...
2025-01-2214 minSinapsos Podcast | OncologyRecent Advances in Small-Cell Lung Cancer TherapeuticsE17 | 19 min | Latest | Publication Source
Podcast based on: Das S, Samaddar S. Recent Advances in the Clinical Translation of Small-Cell Lung Cancer Therapeutics. Cancers. 2025; 17(2):255. https://doi.org/10.3390/cancers17020255
Type: Review | Publication date: Jan 14, 2025
Summary: This research review comprehensively examines small-cell lung cancer (SCLC), a highly aggressive and often fatal lung cancer. It details SCLC's cellular origins, neuroendocrine characteristics, and diverse subtypes driven by distinct transcriptional regulators. The review also explores the mechanisms of chemoresistance, focusing on DNA damage response pathways, cancer stem cells, and epigenetic reprogramming. Finally, it summarises recent advancements and ongoing clinical trials investi...
2025-01-2119 minSinapsos Podcast | OncologyTumor Dormancy: Clinical Opportunities and ChallengesE16 | 16 min | Latest | Publication Source
Podcast based on: Boydell E, Borgeaud M, Tsantoulis P. Dormant Tumor Cells: Current Opportunities and Challenges in Clinical Practice. Onco. 2025; 5(1):3. https://doi.org/10.3390/onco5010003
Type: Review | Publication date: Jan 10, 2025
Summary: This research review examines dormant tumour cells, cells that remain inactive after cancer treatment, potentially causing relapse. It explores the molecular mechanisms underlying dormancy, the role of the immune system and microenvironment, and the challenges in detecting these cells clinically. The review also discusses potential therapeutic strategies, including maintaining dormancy, eradicating dormant cells, and targeting the tumour's niche, highlighting the complexiti...
2025-01-2016 minSinapsos Podcast | OncologyDairy Consumption and Digestive CancersE15 | 13 min | Latest | Publication Source
Podcast based on: Oncina-Cánovas A, Torres-Collado L, García-de-la-Hera M, Compañ-Gabucio LM, González-Palacios S, Signes-Pastor AJ, Vioque J. Association Between Dairy Products Consumption and Esophageal, Stomach, and Pancreatic Cancers in the PANESOES Multi Case–Control Study. Cancers. 2024; 16(24):4151. https://doi.org/10.3390/cancers16244151
Type: Article | Publication date: Jan 12, 2025
Summary: This research investigated the link between dairy product consumption and the risk of esophageal, stomach, and pancreatic cancers. A case-control study of 1229 participants found that fermented dairy products were associated with a reduced risk of esophageal and stomach cancers, while high consumpti...
2025-01-1713 minSinapsos Podcast | OncologyMRgRT Utilization: A Six-Year Institutional AnalysisE14 | 15 min | Latest | Publication Source
Podcast based on: Herrera RA, Akdemir EY, Kotecha R, Mittauer KE, Hall MD, Kaiser A, Bassiri-Gharb N, Kalman NS, Weiss Y, Romaguera T, et al. Evolving Trends and Patterns of Utilization of Magnetic Resonance-Guided Radiotherapy at a Single Institution, 2018–2024. Cancers. 2025; 17(2):208. https://doi.org/10.3390/cancers17020208
Type: Article | Publication date: Jan 10, 2025
Summary: This study retrospectively analyses six years of magnetic resonance-guided radiotherapy (MRgRT) use at a single institution. The focus is on the treatment of abdominal and pelvic tumours, utilising high doses and ultra-hypofractionation (UHfx). A significant increase in the use of on-table adap...
2025-01-1615 minSinapsos Podcast | OncologyAnal Cancer Screening: A 10 Year ExperienceE13 | 10 min | Latest | Publication Source
Podcast based on: Espirito Santo I, Kefleyesus A, Chilou C, Faes S, Clerc D, Hübner M, Hahnloser D, Grass F. Anal Cancer Screening: 10-Year Experience of a Specialized Outpatient Clinic. Cancers. 2025; 17(2):193. https://doi.org/10.3390/cancers17020193
Type: Article | Publication date: Jan 9, 2025
Summary: This ten-year longitudinal study from Lausanne University Hospital analysed 537 patients attending a high-resolution anoscopy (HRA) clinic for anal cancer screening. Almost half presented with dysplastic lesions, mostly low-grade, with only a small percentage progressing to more serious conditions. High-risk HPV genotypes, detectable HIV viral load, and initial symptoms were i...
2025-01-1510 minSinapsos Podcast | OncologyCervical Cancer Screening Beliefs and PerceptionsE12 | 10 min | Latest | Publication Source
Podcast based on: Muresu N, Sechi I, Puci MV, Dettori M, Piana A. Beliefs and Perceptions in Attending the Cervical Screening: The COMUNISS Project Experience. Cancers. 2025; 17(2):190. https://doi.org/10.3390/cancers17020190
Type: Communication | Publication date: Jan 9, 2025
Summary: This study, conducted as part of the COMUNISS project, investigated factors influencing cervical cancer screening participation in a North Sardinian population. A web-based survey using the Health Belief Model assessed women's knowledge, beliefs, and perceptions regarding HPV and cervical cancer prevention. Results revealed significant knowledge gaps and highlighted the influence of perceived barriers and benefits o...
2025-01-1409 minSinapsos Podcast | OncologyPostoperative Adjuvant Therapies and Survival in High-Risk Endometrial CancerE11 | 15 min | Latest | Publication Source
Podcast based on: Lee HJ, Lee B. Impacts of Postoperative Adjuvant Therapies on the Survival of Women with High-Risk Early-Stage Endometrial Cancer: A Cohort Study. Cancers. 2025; 17(2):187. https://doi.org/10.3390/cancers17020187
Type: Article | Publication date: Jan 7, 2025
Summary: This Korean cohort study investigated the impact of various postoperative adjuvant therapies on the overall survival (OS) of women with high-risk early-stage endometrial cancer. The researchers analysed data from 1341 patients, comparing OS across different treatment groups including radiotherapy, chemotherapy, and hormone therapy. Results indicated that most adjuvant therapies yielded similar OS rates, except for adjuvant r...
2025-01-1315 minSinapsos Podcast | OncologyArtificial intelligence in breast cancer survival predictionE10 | 13 min | Latest | Publication Source
Podcast based on: Javanmard Z, Zarean Shahraki S, Safari K, Omidi A, Raoufi S, Rajabi M, Akbari ME and Aria M (2025) Artificial intelligence in breast cancer survival prediction: a comprehensive systematic review and meta-analysis. Front. Oncol. 14:1420328. doi: 10.3389/fonc.2024.1420328
https://doi.org/10.3389/fonc.2024.1420328
Type: Review | Publication date: Jan 7, 2025
Summary: This systematic review and meta-analysis assesses the use of artificial intelligence (AI) and machine learning (ML) algorithms in predicting breast cancer survival. The study examined 32 articles, finding a mean validation accuracy of 89.73% across various ML methods, with hybrid models showing the highest ac...
2025-01-1013 minSinapsos Podcast | OncologyMetabolic Signaling in the Tumor MicroenvironmentE9 | 12 min | Latest | Publication Source
Podcast based on: Clay R, Li K, Jin L. Metabolic Signaling in the Tumor Microenvironment. Cancers. 2025; 17(1):155. https://doi.org/10.3390/cancers17010155
Type: Review | Publication date: Jan 6, 2025
Summary: This review article examines metabolic signalling within the tumour microenvironment (TME), focusing on how cancer cells reprogram their metabolism to promote growth and suppress anti-tumour immunity. It explores the roles of key metabolites, such as lactate, glutamine, and adenosine, in intercellular communication and the creation of a hostile TME. The article details how these metabolites affect various cell types, including immune cells and stromal cells...
2025-01-0912 minSinapsos Podcast | OncologyThe Role of Chronic Inflammation in Pediatric CancerE8 | 17 min | Latest | Publication Source
Podcast based on: Mella C, Tsarouhas P, Brockwell M, Ball HC. The Role of Chronic Inflammation in Pediatric Cancer. Cancers. 2025; 17(1):154. https://doi.org/10.3390/cancers17010154
Type: Review | Publication date: Jan 6, 2025
Summary: This research review examines the significant role of chronic inflammation in the development and progression of childhood cancers. It highlights key differences between adult and paediatric cancers, emphasising that adult cancer research findings are not directly transferable. The review focuses on how chronic inflammation contributes to genetic and epigenetic instability, shapes the tumour microenvironment, and impacts the immature immune response in chi...
2025-01-0817 minSinapsos Podcast | OncologyUrine VOCs and Cancer DetectionE7 | 13 min | Latest | Publication Source
Podcast based on: Hara T, Meng S, Arao Y, Saito Y, Inoue K, Alshammari AH, Hatakeyama H, di Luccio E, Vecchione A, Hirotsu T, et al. Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine. Biomedicines. 2025; 13(1):109. https://doi.org/10.3390/biomedicines13010109
Type: Review | Publication date: Jan 6, 2025
Summary: This review article examines the potential of volatile organic compounds (VOCs) in urine as non-invasive cancer biomarkers. It explores several detection methods, including mass spectrometry analysis of VOC profiles in various cancers, the use of trained organisms (dogs and nematodes) to detect cancer-specific...
2025-01-0713 minSinapsos Podcast | OncologyOligometastatic Prostate Cancer: Current Understanding and Future DirectionsE6 | 10 min | Latest | Publication Source
Podcast based on: Alerasool P, Zhou S, Miller E, Anker J, Tsao B, Kyprianou N, Tsao C-K. A Personalized Approach for Oligometastatic Prostate Cancer: Current Understanding and Future Directions. Cancers. 2025; 17(1):147. https://doi.org/10.3390/cancers17010147
Type: Review | Publication date: Jan 5, 2025
Summary: This research review examines oligometastatic prostate cancer (OMPC), an intermediate stage between localised and widespread disease offering potential for cure. The article explores diagnostic challenges, focusing on PSMA PET scans, and reviews current treatment strategies, including metastasis-directed therapy (MDT) and combinations of systemic therapies with prostate cytoreduction. Ongoing clinical trials investig...
2025-01-0710 minSinapsos Podcast | OncologyGlioblastoma: Multidisciplinary Management and Long-Term OutcomesE5 | 14 min | Latest | Publication Source
Podcast based on: Sipos D, Raposa BL, Freihat O, Simon M, Mekis N, Cornacchione P, Kovács Á. Glioblastoma: Clinical Presentation, Multidisciplinary Management, and Long-Term Outcomes. Cancers. 2025; 17(1):146. https://doi.org/10.3390/cancers17010146
Type: Review | Publication date: Jan 5, 2025
Summary: This document comprehensively examines glioblastoma, the most aggressive form of brain cancer. It details the disease's diagnosis, utilising advanced imaging and molecular markers like IDH mutation and MGMT methylation status for prognosis. Standard treatment, involving surgery, radiation, and chemotherapy (temozolomide), is discussed alongside emerging therapies such as TTFields and immunotherapies. The text also addresses the imp...
2025-01-0714 minSinapsos Podcast | OncologyAI-Enhanced Skin Cancer DiagnosisE4 | 10 min | Latest | Publication Source
Podcast based on: Chiu T-M, Li Y-C, Chi I-C, Tseng M-H. AI-Driven Enhancement of Skin Cancer Diagnosis: A Two-Stage Voting Ensemble Approach Using Dermoscopic Data. Cancers. 2025; 17(1):137. https://doi.org/10.3390/cancers17010137
Type: Article | Publication date: Jan 3, 2025
Summary: This research paper details the development and validation of an AI model for skin cancer diagnosis using dermoscopic images. A two-stage classification approach, employing an ensemble of pre-trained convolutional neural networks and vision transformers, significantly improved diagnostic accuracy and drastically reduced false negatives in both a Western (ISIC) and Eastern (CSMUH) dataset. The model distingui...
2025-01-0710 minSinapsos Podcast | OncologyExploring the Metabolic Impact of FLASH RadiotherapyE3 | 20 min | Latest | Publication Source
Podcast based on: Geirnaert F, Kerkhove L, Montay-Gruel P, Gevaert T, Dufait I, De Ridder M. Exploring the Metabolic Impact of FLASH Radiotherapy. Cancers. 2025; 17(1):133. https://doi.org/10.3390/cancers17010133
Type: Review | Publication date: Jan 3, 2025
Summary: This review article examines the metabolic effects of flash radiotherapy (flash RT), a novel cancer treatment delivering radiation at ultra-high dose rates. The authors explore how flash RT impacts cellular metabolism differently in healthy versus cancerous tissues, focusing on reactive oxygen species (ROS), iron metabolism, lipid peroxidation, and mitochondrial function. Key findings suggest flash RT reduces ROS-ind...
2025-01-0619 minSinapsos Podcast | OncologyHead and Neck Cancer Re-irradiation OutcomesE2 | 8 min | Latest | Publication Source
Podcast based on: Schleifenbaum, J.K., Morgenthaler, J., Sharma, S.J. et al. Optimising (re-)irradiation for locally recurrent head and neck cancer: impact of dose-escalation, salvage surgery, PEG tube and biomarkers on oncological outcomes—a single centre analysis. Radiat Oncol 20, 1 (2025). https://doi.org/10.1186/s13014-024-02570-y
Type: Article | Publication date: Jan 2, 2025
Summary: This single-centre retrospective study analysed outcomes for 101 patients with locally recurrent head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy (RT), with or without chemotherapy or immunotherapy, between 2010 and 2018. The study identified several prognostic factors influenci...
2025-01-0608 minSinapsos Podcast | OncologyComplication Rates After Mastectomy in Breast Cancer: HFRT vs Conventional FractionationE1 | 12 min | Latest | Publication Source
Podcast based on: Falick Michaeli T, Hatoom F, Skripai A, Wajnryt E, Allweis TM, Paluch-Shimon S, Shachar Y, Popovtzer A, Wygoda M, Blumenfeld P. Complication Rates After Mastectomy and Reconstruction in Breast Cancer Patients Treated with Hypofractionated Radiation Therapy Compared to Conventional Fractionation: A Single Institutional Analysis. Cancers. 2025; 17(1):106. https://doi.org/10.3390/cancers17010106
Type: Article | Publication date: Jan 1, 2025
Summary: This single-institution retrospective study compared complication rates after post-mastectomy radiotherapy (PMRT) using hypofractionated (HF) versus conventional fractionation (CF) in 59 breast cancer patients who underwent reconstruction.
Keywords: breast cancer; PMRT; hypofractionati...
2025-01-0512 min