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Surfing the MASH TsunamiS5 - E5.6 - From The Vault: Tsunami's First Look At MASEF, A Major New NITThis conversation comes from our first look at MASEF, last September, when lead author Mazen Noureddin joined the Surfers to discuss his recent breakthrough paper on this new NIT. The original conversation had a robust write-up: Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). In late July, Mazen co-authored a paper on the subject which was published in Hepatology.This conversation begins with Louise’s initial response around the setting of application for MASEF. She poses a ques...2024-03-1013 min

Surfing the MASH TsunamiS4-E46.3 - The Liver Meeting 2023: Updates with Key Opinion Leader, Naim AlkhouriThis week on Surfing NASH, host Roger Green embarks on a series of one on one interviews with KOLs and patient advocates to talk about the Liver Meeting 2023 (held in Boston from November 10 - 14) and much more. In this conversation, friend of the podcast, Naim Alkhouri, joins to discuss this highly anticipated event as well as offer a glimpse into his current work and research interests.The Liver Meeting is known for its exceptional educational content and amazing presenters. This year will be no exception and, if you can't make it to Boston, the state-of-the-art lectures will...2023-11-0520 min

Surfing the MASH TsunamiS4-E46.4 - The Liver Meeting 2023: Updates with Key Opinion Leader, Scott IsaacsThis week on Surfing NASH, host Roger Green embarks on a series of one on one interviews with KOLs and patient advocates to talk about the Liver Meeting 2023 (held in Boston from November 10 - 14) and much more. In this conversation, Key Opinion Leader, Scott Isaacs, joins to discuss this highly anticipated event as well as offer a glimpse into his current work and research interests.The Liver Meeting is known for its exceptional educational content and amazing presenters. This year will be no exception and, if you can't make it to Boston, the state-of-the-art lectures will also...2023-11-0524 min

Surfing the MASH TsunamiS4-E46.2 - Anticipating TLM 2023 with Michael BetelThis week on Surfing NASH, host Roger Green embarks on a series of one on one interviews with KOLs and patient advocates to talk about anticipations around the Liver Meeting 2023 (held in Boston from November 10 - 14) and much more. In this session, President of the Fatty Liver Alliance, Michael Betel, joins to discuss this highly anticipated event, plus some additional key ideas around patient advocacy.The Liver Meeting is known for its exceptional educational content and amazing presenters. This year will be no exception and, if you can't make it to Boston, the state-of-the-art lectures will also b...2023-11-0127 min

Surfing the MASH TsunamiS4-E46.1 - The Liver Meeting 2023: Updates with Key Opinion Leader, Jörn SchattenbergThis week on Surfing NASH, host Roger Green embarks on a series of one on one interviews with KOLs and patient advocates to talk about the Liver Meeting 2023 (held in Boston from November 10 - 14) and much more. In this first conversation, Jörn Schattenberg joins to discuss this highly anticipated event as well as offer a glimpse into his current work and research interests.The Liver Meeting is known for its exceptional educational content and amazing presenters. This year will be no exception and, if you can't make it to Boston, the state-of-the-art lectures will also be a...2023-10-3023 min

Surfing the MASH TsunamiS4-E45.4 - From the Vault: Tetiana Deshko on the public health care in Ukraine during the invasionIn continuation of the Surfing NASH interview series, Roger Green talks to Professor Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical Center. This is a powerful discussion which touches on the Hamas invasion on October 7 and its aftermath on the Israeli people and the practice of medicine today. This conversation From the Vault reprises our earlier interview from June with Tetiana Deshko, Director of Programs for the Alliance for Public Health in Ukraine. Dr. Deshko shared her own experience with the challenges of providing health for patients in the midst of an invasion...2023-10-2629 min

Surfing the MASH TsunamiS4-E45.3 - The Impact of War on a Leading Clinical Trial SiteIn continuation of the Surfing NASH interview series, Roger Green talks to Professor Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical Center. This is a powerful discussion which touches on the Hamas invasion on October 7 and its aftermath on the Israeli people and the practice of medicine today. In this conversation, Oren discusses ways that the Hamas invasion and slaughter have affected the collective perspective of Israelis. At the end, he also shares concerns about the long-term impact of the invasion and likely war to come on the practice of hepatology at his...2023-10-2613 min

Surfing the MASH TsunamiS4-E45.2 - Hepatology Under Air RaidsIn continuation of the Surfing NASH interview series, Roger Green talks to Professor Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical Center. This is a powerful discussion which touches on the Hamas invasion on October 7 and its aftermath on the Israeli people and the practice of medicine today. In this conversation, Oren discusses how the events of October 7 have affected the Israeli medical system, focusing largely on the practice of hepatology. Along the way, you will get a flavor of what it is like to live in a place where air raid sirens ring 5-6...2023-10-2613 min

Surfing the MASH TsunamiS4-E45.1 - Meeting Professor Oren ShiboletIn continuation of the Surfing NASH interview series, this week Roger Green talks to Professor Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical Center. This is a powerful discussion which touches on the Hamas invasion on October 7 and its aftermath on the Israeli people and the practice of medicine today. This first conversation starts with Professor Shibolet talking about his career history. From there he shifts to discuss his experiences of October 7, the devastating day of the Hamas terrorist attack. If you have questions or comments stemming from this episode, or...2023-10-2211 min

Surfing the MASH TsunamiS4-E45 - Interview with Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical CenterIn continuation of the Surfing NASH interview series, this week Roger Green talks to Professor Oren Shibolet, Head of Gastroenterology and Hepatology at the Tel Aviv Medical Center. This is a powerful discussion which touches on the Hamas invasion on October 7 and its aftermath on the Israeli people and the practice of medicine today. Surf on to learn more about this current complex issue and more.If you have questions or comments stemming from this episode, or the interview series in general, we kindly ask that you submit reviews wherever you download the discourse. Alternatively, you can...2023-10-2140 min

Surfing the MASH TsunamiS4-E44.4 - How does MASH and MASLD differ in women compared to men?This week on SurfingNASH, we introduce the audience to new guest, Dr Roberta Forlano, who's been awarded an EASL Juan Rodes PhD Fellowship and has completed a PhD in Translational Hepatology at Imperial college London in 2022. Her current research interest are screening strategies for NAFLD in primary care, automated quantitation of histological features , lifestyle management, CV risk assessment and non-invasive markers in NAFLD. These interests and much more are shared and discussed with Jörn Schattenberg, Louise Campbell and Roger Green in a compelling episode with an overarching theme focusing on screening strategies for gender-based SLD challenges. To offer a...2023-10-1515 min

Surfing the MASH TsunamiS4-E44.3 - Roberta Forlano on Different Challenges for Different Patient PopulationsThis week on SurfingNASH, we introduce the audience to new guest, Dr Roberta Forlano, who's been awarded an EASL Juan Rodes PhD Fellowship and has completed a PhD in Translational Hepatology at Imperial college London in 2022. Her current research interest are screening strategies for NAFLD in primary care, automated quantitation of histological features , lifestyle management, CV risk assessment and non-invasive markers in NAFLD. These interests and much more are shared and discussed with Jörn Schattenberg, Louise Campbell and Roger Green in a compelling episode with an overarching theme focusing on screening strategies for gender-based SLD challenges. To offer a...2023-10-1409 min

Surfing the MASH TsunamiS4-E44.2 - Investigating False Negative Screening RatesThis week on SurfingNASH, we introduce the audience to new guest, Dr Roberta Forlano, who's been awarded an EASL Juan Rodes PhD Fellowship and has completed a PhD in Translational Hepatology at Imperial college London in 2022. Her current research interest are screening strategies for NAFLD in primary care, automated quantitation of histological features , lifestyle management, CV risk assessment and non-invasive markers in NAFLD. These interests and much more are shared and discussed with Jörn Schattenberg, Louise Campbell and Roger Green in a compelling episode with an overarching theme focusing on screening strategies for gender-based SLD challenges. To offer a...2023-10-1413 min

Surfing the MASH TsunamiS4-E44.1 - Introducing Roberta Forlano and a Variety of Compelling Research InterestsThis week on SurfingNASH, we introduce the audience to new guest, Dr Roberta Forlano, who's been awarded an EASL Juan Rodes PhD Fellowship and has completed a PhD in Translational Hepatology at Imperial College London in 2022. Her current research interest are screening strategies for NAFLD in primary care, automated quantitation of histological features , lifestyle management, CV risk assessment and non-invasive markers in NAFLD. These interests and much more are shared and discussed with Jörn Schattenberg, Louise Campbell and Roger Green in a compelling episode with an overarching theme focusing on screening strategies for gender-based SLD challenges. To offer a...2023-10-1410 min

Surfing the MASH TsunamiS4-E44 - Screening Strategies for Gender-Based SLD ChallengesThis week on SurfingNASH, we introduce the audience to new guest, Dr Roberta Forlano, who's been awarded an EASL Juan Rodes PhD Fellowship and has completed a PhD in Translational Hepatology at Imperial college London in 2022. Her current research interest are screening strategies for NAFLD in primary care, automated quantitation of histological features , lifestyle management, CV risk assessment and non-invasive markers in NAFLD. These interests and much more are shared and discussed with Jörn Schattenberg, Louise Campbell and Roger Green in a compelling episode with an overarching theme focusing on screening strategies for gender-based SLD challenges. To offer a...2023-10-1150 min

Surfing the MASH TsunamiS4-E43.6 - Career Advice on Academia vs Corporate LifeThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0808 min

Surfing the MASH TsunamiS4-E43.5 - Corporate life vs academia: which is right for who?This week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0809 min

Surfing the MASH TsunamiS4-E43.4 - Michelle Long on Academia vs IndustryThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0812 min

Surfing the MASH TsunamiS4-E43.3 - Rachel Zayas on the Trajectory of and Intentionality Behind AGED DiagnosticsThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0709 min

Surfing the MASH TsunamiS4-E43.2 - CEO Rachel Zayas on Fundraising and Venture CompetitionsThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0710 min

Surfing the MASH TsunamiS3-E43.1 - Rachel Zayas on the Product Development Process of AGED DiagnosticsThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0709 min

Surfing the MASH TsunamiS4-E43 - Focus on Career Stories and EntrepreneurshipThis week, SurfingNASH offers an episode comprising two seperate interviews which focus on stories around career trajectories, transitions and entrepreneurship. Host Roger Green talks with Rachel Zayas (AGED Diagnostics) and Michelle Long (Novo Nordisk) about their unique stories and creating new opportunities amidst a field with broadening but sometimes opaque horizons. These discussions will be very informative for those who may be wondering about what's on the other side, whether it be commercial medicine or academia. Surf on to learn more as Rachel and Michelle expand on bridging these gaps, managing challenges and their excitement for new ways forward.2023-10-0655 min

Surfing the MASH TsunamiS4-E42.4 - Hannes Hagström on the Broad Aperture of the SLD SummitThe EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD.In this episode, Jörn Schattenberg, Louise Campbell and Roger Green review the recently concluded meeting with faculty members Sven Francque and Hannes Hagström in two seperate interviews.This conversation featuring Hannes starts with him discussing a couple of very exciting projects that his lab at the Karolinska Institute is working on now. After which, Roger asks Hannes an...2023-10-0618 min

Surfing the MASH TsunamiS4-E42.5 - Final Recap of the 2023 SLD Summit: Takeaways and Looking ForwardThe EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD.In this episode, Jörn Schattenberg, Louise Campbell and Roger Green review the recently concluded meeting with faculty members Sven Francque and Hannes Hagström in two seperate interviews.This final conversation starts with Roger’s observation that one reason the energy in this meeting might have been higher is sessions like this one, that was less about sharing answ...2023-10-0613 min

Surfing the MASH TsunamiS4-E42.6 - From the Vault: NAFLD Summit in Context and Learning from Failed TrialsThis episode From the Vault comes from last year's SurfingNASH review of the 2022 NAFLD Summit with Mazen Noureddin, Sven Francque and Hannes Hagström.The 2022 NAFLD Summit uniquely presented a range of perspectives and insights on fatty liver and metabolic diseases.Program speakers Mazen Noureddin, Sven Francque and Hannes Hagström join Surfer, Roger Green, on site from Dublin to review their reactions immediately after the conference ended. At the outset of this episode, the group discusses the benefits of participating in a smaller conference more focused on the challenges presented by the field of NA...2023-10-0613 min

Surfing the MASH TsunamiS4-E42.3 - Diving into Research from the EASL SLD SummitThe EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD.In this episode, Jörn Schattenberg, Louise Campbell and Roger Green review the recently concluded meeting with faculty members Sven Francque and Hannes Hagström in two seperate interviews. This final conversation from our interview with Sven centers on the research that Sven and his colleagues presented at the SLD Summit. Most of this research focuses on portal pressures in...2023-09-3012 min

Surfing the MASH TsunamiS4-E42.2 - MASH, MetALD and Alcoholic SLD: A Continuum?The EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD.In this episode, Jörn Schattenberg, Louise Campbell and Roger Green review the recently concluded meeting with faculty members Sven Francque and Hannes Hagström in two seperate interviews. This conversation starts with Roger asking Sven for his impression about whether the three diseases - MASH, MetALD, Alcoholic SLD - lie on a single continuum or whether the alcoholic an...2023-09-3009 min

Surfing the MASH TsunamiS4-E42.1 - Sven Francque on Organizing the EASL SLD SummitThe EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD.In this episode, Jörn Schattenberg, Louise Campbell and Roger Green review the recently concluded meeting with faculty members Sven Francque and Hannes Hagström in two seperate interviews. The first featured interview is with Sven, who served as one of three organizing members for this year's Summit. In addition, Sven chaired both the opening and closing Plenary sessions on...2023-09-3011 min

Surfing the MASH TsunamiS4-E42 - EASL SLD Summit 2023The EASL SLD Summit aims at updating a global community of liver stakeholders on the most recent advances in SLD research, both pre-clinically and clinically, focusing on MASLD and tackling the issue of MetALD. In this episode onSurfing NASH , Jörn Schattenberg, Louise Campbell and Roger Green review this recently concluded meeting with faculty members Sven Francque and Hannes Hagström. Jörn joins both guests as a fellow presenter and the group dives into program highlights with many fascinating takes and interplaying ideas. The first featured interview is w...2023-09-2959 min

Surfing the MASH TsunamiS4-E41.6 - From the Vault: Highlights from Paris NASH 2021If you missed this year's Paris NASH meeting, you missed some exciting presentations featuring fresh, pivotal insights about Fatty Liver diseases and some new approaches to learning about this disease. For this episode From the Vault, we take a look back at what has by far been the most downloaded episode in the history of the podcast: S2-E46 - Highlights from Paris NASH 2021. Jörn Schattenberg and Stephen Harrison combine to provide a robust synopsis of the meeting while Roger Green asks a few questions and keeps the discussion in-bounds:10:20 – Jörn introduces Paris NASH...2023-09-2415 min

Surfing the MASH TsunamiS4-E41.5 - Veronica Miller on “why are we validating a surrogate with a surrogate?”In Season 4, Episode 41, the surfers (Jörn Schattenberg, Louise Campbell and Roger Green) review highlights from the FDA's NIT workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives.This conversation is the first part of the Surfer’s interview with Veronica. Veronica starts by commending FDA for organizing the workshop and indicates that now we all need to process the data. Roger asks Veronica what FDA might have done better, and she indicates they mig...2023-09-2415 min

Surfing the MASH TsunamiS4-E41.4 - NITs to Qualify Patients for Trials vs to Evaluate Efficacy of DrugsIn Season 4, Episode 41, the surfers (Jörn Schattenberg, Louise Campbell and Roger Green) review highlights from the FDA's NIT workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives.This conversation begins with discussing a point from a previous episode in 2022 about the difference between NITs to qualify patients for trials versus to evaluate efficacy of drugs. This point stems from the idea that the way disease regresses may not be the same wa...2023-09-2411 min

Surfing the MASH TsunamiS4-E41.3 - Laurent Castera on the FDA's NIT WorkshopIn Season 4, Episode 41, the surfers (Jörn Schattenberg, Louise Campbell and Roger Green) review highlights from the FDA's NIT workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives.This conversation introduces the first part of an interview with Laurent Castera. Roger starts by asking Laurent how he, as one of the few non-American presenters, felt about the meeting. Laurent noted how important the meeting was given that it came from FDA, which th...2023-09-2314 min

Surfing the MASH TsunamiS4-E41.2 - Naim Alkhouri on clinical trial populations and the future decisions of FDAIn Season 4, Episode 41, the surfers (Jörn Schattenberg, Louise Campbell and Roger Green) review highlights from the FDA's NIT workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives.Roger starts this conversation by discussing loss aversion – the idea that an individual’s decision does not reflect an overall fear of risk, but a specific fear of risking something they do not want to lose. Researchers and advocates define loss in terms of time t...2023-09-2315 min

Surfing the MASH TsunamiS4-E41.1 - Naim Alkhouri on an NIT-based alternative path to conditional approvalIn Season 4, Episode 41, the surfers (Jörn Schattenberg, Louise Campbell and Roger Green) review highlights from the FDA's NIT workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives. This conversation covers the first part of our interview with Naim, who served as an expert panelist in Tuesday’s penultimate session. The conversation starts with Naim commending the session and noting that what drug developers and principal investigators truly are seeking is an NIT-b...2023-09-2313 min

Surfing the MASH TsunamiS4-E41 - Reviewing the FDA's NIT WorkshopOn September 18-19, the FDA hosted a workshop to update key stakeholders on the state-of-the-art use of biomarkers and noninvasive tests (NITs) based on recent advances in NASH/metabolic dysfunction associated steatohepatitis (MASH) clinical trials. In this episode, Surfing NASH reviews highlights from the workshop in three seperate interview sessions with guests Naim Alkhouri, Laurent Castera and Veronica Miller. Each guest participated in some form at the meeting and shares slightly differing but incredibly insightful perspectives with Surfers Jörn Schattenberg, Louise Campbell and Roger Green. Naim elaborates on the limitations of current pathways and the possibilities of...2023-09-221h 18

Surfing the MASH TsunamiS4-E40.5 - Paris NASH Review: More Topics and Final ThoughtsAlong with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1713 min

Surfing the MASH TsunamiS4-E40.4 - Challenges in Treating and Assessing AdequatelyAlong with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1713 min

Surfing the MASH TsunamiS4-E40.3 - Which test is best for which patients?Along with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1611 min

Surfing the MASH TsunamiS4-E40.2 - Deeper Dive into the Landscape of NITsAlong with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1608 min

Surfing the MASH TsunamiS4-E40.1 - Liver as a Regenerative Organ and the Use and Limitations of NITsAlong with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1611 min

Surfing the MASH TsunamiS4-E40 - Review of Paris NASH 2023Along with NASH-TAG, Paris NASH is one of two famously small, science-based and publicly available events every year for the liver community. Given the depth of topics and ideas explored in Paris, the event in its entirety would be nearly impossible to cover in a single conclusive episode. That said, the Surfers (Jörn Schattenberg, Louise Campbell and Roger Green) are joined by two presenting KOLs, Scott Friedman and Laurent Castera, for a neatly packaged conversation to capture some of the key dynamics of the meeting. Particularly, the group hone in on developments in the landscape around NITs.2023-09-1452 min

Surfing the MASH TsunamiS4-E39.4 - MASEF: Where will we be in 2 years?Surfing NASH returns to its regular program with a fresh episode and some fascinating and progressive ideas around non-invasive testing. Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). In late July, Mazen co-authored a paper on the subject which was published in Hepatology.This final conversation starts with Louise’s curiosity on whether any socioeconomic differences were clear between those considered at-risk. Mazen responds with his belief that there would be much to benefit from studying a larger prospective coh...2023-09-0309 min

Surfing the MASH TsunamiS4-E39.3 - MASEF: Next Steps and New CohortsSurfing NASH returns to its regular program with a fresh episode and some fascinating and progressive ideas around non-invasive testing. Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). In late July, Mazen co-authored a paper on the subject which was published in Hepatology.This conversation begins with Louise’s focus on pediatric cohorts and whether MASEF can be applied to younger populations. Mazen states that while it has yet to be applied in this way, he would be very int...2023-09-0310 min

Surfing the MASH TsunamiS4-E39.2 - MASEF: Cost Effectiveness and Application SettingsSurfing NASH returns to its regular program with a fresh episode and some fascinating and progressive ideas around non-invasive testing. Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). In late July, Mazen co-authored a paper on the subject which was published in Hepatology.This conversation begins with Louise’s initial response around the setting of application for MASEF. She poses a question that leads the group to explore possible pros and cons of different approaches and the potential impact eac...2023-09-0213 min

Surfing the MASH TsunamiS4-E39.1 - MASEF: Study Parameters and Notable ResultsSurfing NASH returns to its regular program with a fresh episode and some fascinating and progressive ideas around non-invasive testing. Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). In late July, Mazen co-authored a paper on the subject which was published in Hepatology.For this opening conversation, Mazen cogently introduces why and how MASEF came to exist as an emerging noninvasive test. He first notes the utility of the HbA1c test - one of the commonly used tests t...2023-09-0211 min

Surfing the MASH TsunamiS4-E39 - The Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF)This week, Surfing NASH returns to its regular program with a fresh episode and some fascinating and progressive ideas around non-invasive testing. Mazen Noureddin joins co-hosts Jörn Schattenberg, Louise Campbell and Roger Green to discuss serum identification of at-risk MASH and the Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF). Mazen co-authored a paper on the subject which was published in Hepatology as recent as late July. In a nutshell, this episode elucidates on developing and validating a highly specific metabolomics-driven score to identify at-risk MASH (metabolic dysfunction-associated steatohepatitis) patients. Ultimately, the paper concludes MASEF to indeed b...2023-08-3146 min

Surfing the MASH TsunamiS4-E38.2 - On the Importance of Multidisciplinary TeamsLast week SurfingNASH offered a final re-focus on an episode that originally aired during Season 1. Continuing on the focus around allied health, this session dives into the role of nurses, physicians and allied health professionals in supporting NASH patients - a topic of increasing relevance as the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals. Specifically, the group explores whether healthcare systems can be as effective as companies like Noom and WeightWatchers.Louise start this conversation by agreeing with Peter's comment about the importance of team care and discusses...2023-08-2913 min

Surfing the MASH TsunamiS4-E38.1 - 3 Important Questions to Consider for Full Patient SupportLast week SurfingNASH offered a final re-focus on an episode that originally aired during Season 1. Continuing on the focus around allied health, this session dives into the role of nurses, physicians and allied health professionals in supporting NASH patients - a topic of increasing relevance as the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals. Specifically, the group explores whether healthcare systems can be as effective as companies like Noom and WeightWatchers. This fascinating conversation features ideas shared by Stephen Harrison, Peter Traber (Chief Medical Officer at Selecta Biosciences...2023-08-2911 min

Surfing the MASH TsunamiS4-E38.4 - On the Capabilities of The Health Care SystemsLast week SurfingNASH offered a final re-focus on an episode that originally aired during Season 1. Continuing on the focus around allied health, this session dives into the role of nurses, physicians and allied health professionals in supporting NASH patients - a topic of increasing relevance as the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals. Specifically, the group explores whether healthcare systems can be as effective as companies like Noom and WeightWatchers.If you have questions or comments around our From the Vault series, allied health, education...2023-08-2906 min

Surfing the MASH TsunamiS4-E38.3 - Getting the Right Message to the Right Patient at the Right TimeLast week SurfingNASH offered a final re-focus on an episode that originally aired during Season 1. Continuing on the focus around allied health, this session dives into the role of nurses, physicians and allied health professionals in supporting NASH patients - a topic of increasing relevance as the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals. Specifically, the group explores whether healthcare systems can be as effective as companies like Noom and WeightWatchers.This conversation starts with Louise agreeing enthusiastically with Stephen's comments around keeping things simple. Roger asks Stephen...2023-08-2910 min

Surfing the MASH TsunamiS4-E38 - Nurses Helping NASH PatientsThis week SurfingNASH continues to offer a final re-focus on an episode that originally aired during Season 1. Similar to last week's focus on allied health, this session dives into the role of nurses, physicians and allied health professionals in supporting NASH patients - a topic of increasing relevance as the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals. Specifically, the group explores whether healthcare systems can be as effective as companies like Noom and WeightWatchers. The fascinating conversation features ideas and critical concepts shared by Stephen Harrison, Peter Traber (Chief Medical...2023-08-2436 min

Surfing the MASH TsunamiS4-E37.4 - NASH Patient Care: The Value of Patient EducationSurfingNASH is offering something different for Season 4, Episode 37 while the co-hosts are off enjoying a well-deserved holiday amid a busy year. Rather than leaving a gap in the podcast's program, this week we are revisiting an episode From the Vault that, now more than ever, maintains its relevance. As the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals, education and educational resources are critically needed. This session, led by Louise Campbell, focuses on the roles that allied health can play in prevention, early stage management and clinical trial recruitment for NAFLD...2023-08-2021 min

Surfing the MASH TsunamiS4-E37.3 - NASH Patient Education: Liver Nurses’ RolesSurfingNASH is offering something different for Season 4, Episode 37 while the co-hosts are off enjoying a well-deserved holiday amid a busy year. Rather than leaving a gap in the podcast's program, this week we are revisiting an episode From the Vault that, now more than ever, maintains its relevance. As the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals, education and educational resources are critically needed. This session, led by Louise Campbell, focuses on the roles that allied health can play in prevention, early stage management and clinical trial recruitment for NAFLD...2023-08-1913 min

Surfing the MASH TsunamiS4-E37.2 - NASH Patient Support: Liver Nursing ChallengesSurfingNASH is offering something different for Season 4, Episode 37 while the co-hosts are off enjoying a well-deserved holiday amid a busy year. Rather than leaving a gap in the podcast's program, this week we are revisiting an episode From the Vault that, now more than ever, maintains its relevance. As the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals, education and educational resources are critically needed. This session, led by Louise Campbell, focuses on the roles that allied health can play in prevention, early stage management and clinical trial recruitment for NAFLD...2023-08-1915 min

Surfing the MASH TsunamiS4-E37.1 - NASH Patient Support: Meet Today’s Liver NursesSurfingNASH is offering something different for Season 4, Episode 37 while the co-hosts are off enjoying a well-deserved holiday amid a busy year. Rather than leaving a gap in the podcast's program, this week we are revisiting an episode From the Vault that, now more than ever, maintains its relevance. As the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals, education and educational resources are critically needed. This session, led by Louise Campbell, focuses on the roles that allied health can play in prevention, early stage management and clinical trial recruitment for NAFLD...2023-08-1919 min

Surfing the MASH TsunamiS4-E37 - Focus on the Role of Allied Health and Strengthening NASH EducationSurfingNASH is offering something different for Season 4, Episode 37 while the co-hosts are off enjoying a well-deserved holiday amid a busy year. Rather than leaving a gap in the podcast's program, this week we are revisiting an episode From the Vault that, now more than ever, maintains its relevance. As the field grapples with new nomenclature for liver disease and the imminence of therapeutic approvals, education and educational resources are critically needed. This session, led by Louise Campbell, focuses on the roles that allied health can play in prevention, early stage management and clinical trial recruitment for NAFLD...2023-08-171h 11

Surfing the MASH TsunamiS4-E36.5 - LOCATE-NAFLD: What’s Next and Practical TakeawaysCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss learning from liver disease in Australia and developing improved models for patient identification and risk stratification.This final conversation starts with Roger discussing the idea that upscaling training is very important. Louise follows up with a comment that we must remember these are complicated technologies to use and that dedication to training is pivotal in optimizing their potential. After a digression to consider the size of the indigenous candidates in the study, the gr...2023-08-1310 min

Surfing the MASH TsunamiS4-E36.4 - LOCATE-NAFLD: Funding and Generating DataCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss learning from liver disease in Australia and developing improved models for patient identification and risk stratification.This conversation focuses largely on funding, starting with Louise’s question about Medicare payment for patients in Australia. James notes that all care was free to patients, and that this might skew results. As the conversation continues, Louise notes the importance for Australians of having Australian data to use in valuing medicines, diagnostics and procedures, given that NICE...2023-08-1315 min

Surfing the MASH TsunamiS4-E36.3 - LOCATE-NAFLD: Cost Effectiveness and Implementation in Different SystemsCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss learning from liver disease in Australia and developing improved models for patient identification and risk stratification.This conversation starts with Louise discussing some of the improvements in patient motivation and compliance as a result of FibroScan when administered in specialty sites. From here Roger asks Louise and James how they envision practical implementation of this kind of study design in other countries. Louise speculates on how this might work in 3rd world countries wh...2023-08-1211 min

Surfing the MASH TsunamiS4-E36.2 - LOCATE-NAFLD: Study Design and Early AnalysisCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss learning from liver disease in Australia and developing improved models for patient identification and risk stratification.This conversation proceeds from a high-level overview of the LOCATE-NAFLD study. Discussion opens to comments from the panelists, starting with Naim commending the basic idea of a randomized study and the sample size for this initiative. He goes on to ruminate on how effective this design will be at correctly assessing positive and negative predictive values. James de...2023-08-1211 min

Surfing the MASH TsunamiS4-E36.1 - Meeting James O’Beirne and Introducing the LOCATE-NAFLD StudyCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss learning from liver disease in Australia and developing improved models for patient identification and risk stratification.This conversation starts with an introduction to James both personally and professionally. A Consultant Hepatologist at the Sunshine Coast University Hospital, James describes how he came to his work and interests around risk stratification in liver disease, particularly in NAFLD, hepatocellular carcinoma and portal hypertension. From here Louise shares a bit about why she feels the LOCATE-NAFLD st...2023-08-1213 min

Surfing the MASH TsunamiS4-E36 - LOCATE-NAFLD: Improved Models for Patient Identification and Risk StratificationCo-hosts Louise Campbell and Roger Green are joined by friend of the podcast, Naim Alkhouri, and new guest, Professor James O’Beirne, to discuss liver disease in Australia and developing improved models for patient identification and risk stratification.James , a Consultant Hepatologist at the Sunshine Coast University Hospital, shares his professional background and introduces events which lead to the LOCATE-NAFLD study. After Australia became the first country to allow access to direct-acting antiviral agents for HCV in 2016, there was the strong need to determine which patients were cirrhotic. With relatively unprepared primary care providers, specialist and hospital ca...2023-08-1056 min

Surfing the MASH TsunamiS4-E35.4 - Looking Forward at the SurfingNASH ProgramThe wider community of liver stakeholders witnessed an exciting July as new compelling data and presentations were revealed across two major meetings, EASL Congress and the American Diabetes Association Scientific Sessions. Throughout that month, SurfingNASH provided real-time coverage and review of the emerging stories spanning topics like drug development, new nomenclature, omics and AI, NITs and more. For this episode the trio of co-hosts, Jörn Schattenberg, Louise Campbell and Roger Green, embark on their first exclusive discussion together in a while without any guest panelists. The overarching theme of the program observes what has made 2023 interesting and exciting t...2023-08-0615 min

Surfing the MASH TsunamiS4-E35.3 - Strengthening Patient Involvement, NIT Development and Lessons from AIThe wider community of liver stakeholders witnessed an exciting July as new compelling data and presentations were revealed across two major meetings, EASL Congress and the American Diabetes Association Scientific Sessions. Throughout that month, SurfingNASH provided real-time coverage and review of the emerging stories spanning topics like drug development, new nomenclature, omics and AI, NITs and more. For this episode the trio of co-hosts, Jörn Schattenberg, Louise Campbell and Roger Green, embark on their first exclusive discussion together in a while without any guest panelists. The overarching theme of the program observes what has made 2023 interesting and exciting t...2023-08-0510 min

Surfing the MASH TsunamiS4-E35.2 - Challenges Associated with Communicating New NomenclatureThe wider community of liver stakeholders witnessed an exciting July as new compelling data and presentations were revealed across two major meetings, EASL Congress and the American Diabetes Association Scientific Sessions. Throughout that month, SurfingNASH provided real-time coverage and review of the emerging stories spanning topics like drug development, new nomenclature, omics and AI, NITs and more. For this episode the trio of co-hosts, Jörn Schattenberg, Louise Campbell and Roger Green, embark on their first exclusive discussion together in a while without any guest panelists. The overarching theme of the program observes what has made 2023 interesting and exciting t...2023-08-0509 min

Surfing the MASH TsunamiS4-E35.1 - High-Level Recap of Two Key Events for 2023 Thus FarThe wider community of liver stakeholders witnessed an exciting July as new compelling data and presentations were revealed across two major meetings, EASL Congress and the American Diabetes Association Scientific Sessions. Throughout that month, SurfingNASH provided real-time coverage and review of the emerging stories spanning topics like drug development, new nomenclature, omics and AI, NITs and more. For this episode the trio of co-hosts, Jörn Schattenberg, Louise Campbell and Roger Green, embark on their first exclusive discussion together in a while without any guest panelists. The overarching theme of the program observes what has made 2023 interesting and exciting t...2023-08-0513 min

Surfing the MASH TsunamiS4-E35.5 - From the Vault: The Psychology of Decision-Making Around Diet and Professional SupportThis episode From the Vault looks back to the podcast's first episode dedicated entirely to nutrition and NASH with distinguished guest, Prof. Shira Zelber-Sagi. Surfing alongside this rich discussion are Ken Cusi, Jörn Schattenberg, Louise Campbell and Roger Green.Roger begins this conversation by stating that everyone eventually makes poor dietary choices. The group agrees through various examples that the key is to not let a momentary shortcoming deter progress along the wellness journey. Shira emphasizes that relapse is part of the process and ought to be factored into patients’ long-term plans. She goes on to dis...2023-08-0511 min

Surfing the MASH TsunamiS4-E35 - SurfingNASH 2023 Year-to-Date Review and Looking AheadThe wider community of liver stakeholders witnessed an exciting July as new compelling data and presentations were revealed across two major meetings, EASL Congress and the American Diabetes Association Scientific Sessions. Throughout that month, SurfingNASH provided real-time coverage and review of the emerging stories spanning topics like drug development, new nomenclature, omics and AI, NITs and more. For this episode the trio of co-hosts, Jörn Schattenberg, Louise Campbell and Roger Green, embark on their first exclusive discussion together in a while without any guest panelists. The overarching theme of the program observes what has made 2023 interesting and exciting t...2023-08-0347 min

Surfing the MASH TsunamiS4-E18.5 - Allied Health Professionals and Patient Identification in Endocrinology ClinicsAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor o...2023-04-3013 min

Surfing the MASH TsunamiS4-E18.4 - Empowering Physicians Through Simple Tools and the Demise of BeethovenAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor o...2023-04-3010 min

Surfing the MASH TsunamiS4-E18.3 - Positive Patient Engagement with Biofeedback and NAFLD/NASH in Chronic Kidney PatientsAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor o...2023-04-2910 min

Surfing the MASH TsunamiS4-E18.2 - Risk Stratification and Identification of NAFLD/NASH Patients in the Endocrinology SettingAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor o...2023-04-2914 min

Surfing the MASH TsunamiS4-E18.1 - Meeting Cyrielle Caussy at the Intersection of Endocrinology and HepatologyAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor o...2023-04-2912 min

Surfing the MASH TsunamiS4-E18 - Interplay of Endocrinology and Hepatology in Treatment and Knowledge DevelopmentAs part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green a...2023-04-2754 min

Surfing the MASH TsunamiS4-E16.6 - From the Vault: #NASHDay 2022: SurfingNASH Wrap-UpThursday, June 9, 2022 was the 5th International NASH Day (#NASHDay). Global Liver Institute, the largest liver patient advocacy organization in the world, and 200 partner organizations held a day of education, awareness and motivation for Fatty Liver stakeholders across the globe.For its wrap-up panel, GLI invited the SurfingNASH co-host team to sit with Jeff McIntyre and review some of the day’s major themes as well as major developments since the last International NASH Day. Like a typical SurfingNASH episode, there were equal parts big-picture thinking, references to recent events, and laughs. Listen for a fast-paced discussion of bi...2023-04-1616 min

Surfing the MASH TsunamiS4-E11.1 - The Surfers Highlight What’s Happening for Fatty Liver in 2023The Surfers host a thought-provoking impromptu session on what’s happening thus far for the Fatty Liver field in 2023. Jörn Schattenberg leads this conversation with comments around diagnostic and therapeutic advancements following the momentum gathered at NASH-TAG in January. He points to the large number of abstracts (estimated at over 2500!) submitted to the upcoming EASL Congress held in Vienna this June. While drugs are leading the way, Jörn insists diagnostics are closely following and contributing to "excitement on both borders.” Roger Green notes activity around organizing trials that incorporate non-invasive endpoints.Louise Campbell adds her highli...2023-03-1116 min

Surfing the MASH TsunamiS4-E9.5 - From the Vault: Discussing Comprehensive Care Models For NAFLD: Metrics, Key Performance Indicators and Improving ManagementThis week, SurfingNASH is offering conversation segments to showcase our new series, The NASH Tsunami in Diabetes: Getting Ahead of the Rising Tide. Rising Tide, as we call it, is a subscription-only series targeted at the primary care physicians, endocrinologists and allied health professionals who provide front-line treatments for patients living with Type 2 Diabetes and/or obesity. In this episode From the Vault, Jeff Lazarus and Roger Green discuss the ease of creating valuable metrics in a comprehensive care model, while our three practitioners -- Stephen Harrison, Jörn Schattenberg and Louise Campbell -- dive further into how they be...2023-02-2616 min

Surfing the MASH TsunamiS4-E9.4 - Combating Swelling NAFLD and NASH Prevalence: Drugs, Diagnostics and Guidelines for the FrontlineThis week, SurfingNASH is offering conversation segments to showcase our new series, The NASH Tsunami in Diabetes: Getting Ahead of the Rising Tide. Rising Tide, as we call it, is a subscription-only series targeted at the primary care physicians, endocrinologists and allied health professionals who provide front-line treatments for patients living with Type 2 Diabetes and/or obesity. This sample session comes from the just-released Season 2 debut which focuses comprehensively on a new chapter of the podcast and why 2023 might be “the best year ever” for Fatty Liver.The group considers what made 2022 special. Mazen highlights Madrigal’s positi...2023-02-2616 min

Surfing the MASH TsunamiS4-E9.3 - Diabetes Drug Choices With Benefits For NAFLDThis week, SurfingNASH is offering conversation segments to showcase our new series, The NASH Tsunami in Diabetes: Getting Ahead of the Rising Tide. Rising Tide, as we call it, is a subscription-only series targeted at the primary care physicians, endocrinologists and allied health professionals who provide front-line treatments for patients living with Type 2 Diabetes and/or obesity. This preview looks at drug choices prescribers can make today for patients with Type 2 Diabetes Mellitus and obesity that have positive impact on Fatty Liver disease. In addition to co-hosts Dr. Ken Cusi and Roger Green, panelists for this discussion include endocrinologist...2023-02-2519 min

Surfing the MASH TsunamiS4-E9.2 - What’s Behind The New AACE Fatty Liver Guidelines?This week, SurfingNASH is offering conversation segments to showcase our new series, The NASH Tsunami in Diabetes: Getting Ahead of the Rising Tide. Rising Tide, as we call it, is a subscription-only series targeted at the primary care physicians, endocrinologists and allied health professionals who provide front-line treatments for patients living with Type 2 Diabetes and/or obesity. This preview comes from our second episode which focused on the new AACE Fatty Liver Guidelines.The panelists include four authors of the guidelines: first author Dr. Ken Cusi from the University of Florida, third author Dr. Diana Barb, also...2023-02-2516 min

Surfing the MASH TsunamiS4-E9.1 - Growing NAFLD-Diabetes Dual Prevalence Increases CVD Risk for DiabeticsThis week, SurfingNASH is offering conversation segments to showcase our new series, The NASH Tsunami in Diabetes: Getting Ahead of the Rising Tide. Rising Tide, as we call it, is a subscription-only series targeted at the primary care physicians, endocrinologists and allied health professionals who provide front-line treatments for patients living with Type 2 Diabetes and/or obesity.This sample session comes from the debut episode which focuses on research that has led AACE to issue guidelines, AGA to propose clinical care pathways and AHA to produce a white paper on the links between Fatty Liver Disease and...2023-02-2516 min

Surfing the MASH TsunamiS3-E29 - #NASHDay 2022: SurfingNASH Wrap-upToday, June 9, was the 5th International NASH Day (#NASHDay). Global Liver Institute (@GlobalLiver), the largest liver patient advocacy organization in the world, and 200 partner organizations held a day of education, awareness and motivation for Fatty Liver stakeholders the world around.For its wrap-up panel, GLI invited the SurfingNASH co-host team to sit with Jeff McIntyre and review some of the day's major themes as well as major developments since the last International NASH Day. Like a typical SurfingNASH episode, there were equal parts big picture thinking, references to recent events, and laughs. Listen for a fast-paced discussion...2022-06-101h 01

Surfing the MASH TsunamiS3-E20 - Jörn Schattenberg, Louise and Roger discuss NAFLD and SurfingNASH.comSurfingNASH.com has produced this special, single-interview episode to give listeners a chance to learn about Jörn Schattenberg in a different way as he becomes the permanent Key Opinion Leader on Surfing the NASH Tsunami.Surfing the NASH Tsunami's "Seasons" start with the calendar year, but our first episode posted on April 15, 2020. As we begin our third year, we wanted to give listeners a chance to get to know Jörn Schattenberg a bit differently than you would just from listening to episodes. Jörn discusses how he decided to become a hepatologist, why Stephen Harrison's phr...2022-04-2035 min

Surfing the MASH TsunamiS3-E12 - Non-Hispanic Black Americans, SDOH and NASHIn recognition of Black History Month, SurfingNASH looks at how the impact of NASH on non-Hispanic Black Americans differs from other groups. The episode includes Key Opinion Leaders not only in Fatty Liver disease but also, more broadly, social determinants of health like food insufficiency and clinical trial participation.This episode was originally suggested by Dr. Yani Adere, a Medical Science Liaison at Novo Nordisk and long-time SurfingNASH listener. Yani set the stage for this conversation by noting that while incidence of NASH and NASH cirrhosis may be relatively low among non-Hispanic Black Americans, those who get...2022-02-241h 05

Surfing the MASH TsunamiS3-E3 - NASH-TAG 2022 Day Two: Weight loss, Innovative Approaches and the Fireside Chat on Testing MethodsSurfingNASH is covering each day of NASH-TAG 2022. This episode is a "morning after" conversation with Stephen Harrison, Louise Campbell and Jörn Schattenberg reviewing key points of the Day Two discussions, with particular focus on the two "fireside chats" that wrapped up the program.Day Two of NASH-TAG included presentations of new data on wet markers, imaging and combination therapy, discussion of novel targets and advances in our understanding of basic science. All this led up to the meeting's climax + denouement: David Shapiro's talk on why the current trial and approval system is unsustainable and places unnecessary b...2022-01-0950 min

Surfing the MASH TsunamiS2-E64.3 - SurfingNASH's 2021 NAFLD Year-In-Review Covers The Growing Energy and Impact of NASH Patient AdvocacyThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Andrew Scott, Global Policy Lead for the Global Liver Institute joins Louise Campbell and Roger Green to discuss the growing energy and impact of NASH patient advocacy.This episode focuses on the steps that have increased reach and effectiveness of NASH patient advocacy dramatically in 2021. Andrew starts by noting some of the pivotal steps this year through which patient advocates began or expanded collaborations with the medical community in 2021, and then describing the activities that resulted from these collaborations: Global Liver Institute's (GLI) US NASH Action Plan, the range of...2022-01-0235 min

Surfing the MASH TsunamiS2-E64.2 - SurfingNASH's 2021 NAFLD Year-in-Review Covers the Emerging NAFLD Public Health AgendaThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Jeffrey Lazarus of ISGlobal and the University of Barcelona joins Louise Campbell and Roger Green to discuss the emerging NAFLD public health agenda. Jeff Lazarus comes to the effort to create a global NAFLD Public Health agenda from his experiences spearheading similar efforts in HIV and Hepatitis C. The conversation begins with Jeff describing the path by which he shifted focus from each liver disease to the next. Just as reduction in HIV transition rates revealed the high level of Hepatitis C infections among HIV patients (particularly intravenous...2022-01-0240 min

Surfing the MASH TsunamiS2-E64.1 - SurfingNASH's 2021 NAFLD Year-in-Review Explores Key NASH Themes of the Year Plus the Growth of Our PodcastThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Co-host Dr. Stephen Harrison joins Louise Campbell and Roger Green to review five key NASH themes that emerged in 2021, while simultaneously discussing the year for Surfing the NASH Tsunami.It seems fitting that the first SurfingNASH event of 2022 should include Stephen, Louise and Roger. In this thoughtful, fast-moving conversation, Stephen identifies what he considers five key areas where the Fatty Liver community has progressed in the past year:1. Call to action -- 2021 saw two separate, vitally important calls to action to share the scope of the upcoming NASH...2022-01-0148 min

Surfing the MASH TsunamiS2-E64 - Stephen Harrison, Jeff Lazarus and Andrew Scott Join SurfingNASH.com's 2021 NAFLD Year-in-ReviewThe last half of December marks our annual NAFLD Year-in-Review. Episodes 62-64 each include ~20 minute segments of longer interviews with Stakeholders who have made a dent in Fatty Liver disease in 2021.In this episode, Louise Campbell and Roger Green are joined by Stephen Harrison, Jeff Lazarus and Andrew Scott. Conversation topics vary widely, with Stephen describing on what he sees as the five key themes in his NAFLD 2021 Year-in-Review, Jeff focusing largely on the public health agenda and Andrew discussing the steps by which patient advocacy is becoming an increasing force in public and private...2021-12-311h 01

Surfing the MASH TsunamiS2-E63.3 - SurfingNASH's 2021 NAFLD year-in-review Covers NASH Cost Effectiveness and Quality-of-LifeThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Jörn Schattenberg of the University of Mainz joins Louise Campbell and Roger Green to discuss research and insights regarding NASH cost effectiveness studies and related issues of quality of life.Jörn Schattenberg begins our discussion simply by reviewing some of the year's highlights. His "proof of momentum" statement is unique and dead-on at the same time: Fatty Liver topics were addressed in three New ENgland Journal of Medicine articles this year despite not having a new drug approval. When discussing the Liver International paper on...2021-12-3035 min

Surfing the MASH TsunamiS2-E63.2 - SurfingNASH's 2021 NAFLD year-in-review Covers NASH Multidisciplinary Initiatives and the Clinical Care Pathways PaperThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Kenneth Cusi of the University of Florida joins Louise Campbell and Roger Green to discuss the NASH multidisciplinary initiative organized under the aegis of AGA the resulting paper of Clinical Care Pathways.In 2021, Ken Cusi played an integral role in the NASH Multidisciplinary initiative fostered under the aegis of the American Gastroenterological Association (AGA) and leading to the paper "Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease," originally published in "Gastroenterology". This conversation begins with Ken mentioning some...2021-12-2933 min

Surfing the MASH TsunamiS2-E63.1 - SurfingNASH's 2021 NAFLD year-in-review Covers Cirrhosis Treatment Strategies Today and NASH Drugs in DevelopmentThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Manal Abdelmalek of Duke University joins Louise Campbell and Roger Green to discuss the use of older drugs to treat cirrhosis patients today and her views on where NASH drug development is heading.Manal begins by discussing the inherent tension between the research world, which reveals several promising modes of action and drugs in development but are unlikely to yield a first approval less than two years from now, compared to patient treatment, where people living with cirrhosis are looking for help today. Her talk focuses...2021-12-2835 min

Surfing the MASH TsunamiS2-E62.3 - SurfingNASH's 2021 NAFLD year-in-review Covers the Patient-Advocate Initiated and Sponsored SUNN StudyThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Fatty Liver Foundation Founder and President Wayne Eskridge joins Louise Campbell and Roger Green to discuss the recently-completed SUNN study that was initiated and shepherded by FLF. Wayne discusses study results and the challenges for an orgganization like FLF in conducting this kind of study. Wayne focuses intently on what the study tells us about prevalence of disease in the US. Like the San Antonio Military Medical Center research that Stephen Harrison et al. authored in 2011 and 2021, the study suggested a far higher rate of NAFLD and NASH than t...2021-12-2631 min

Surfing the MASH TsunamiS2-E62.2 - SurfingNASH's 2021 NAFLD year-in-review Covers MRE and the Broader View of Non-Invasive Liver TestingThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Professor Alina Allen of the Mayo Clinic joins Louise Campbell and Roger Green to discuss the rapid progress the profession has made in improving user-friendliness and ease of interpretation of MRE and the coming expansion in the role that non-invasive liver testing will play in the years to come.Alina notes some specific new information about MRE and other non-invasive testing methods that have come to light in the past year. Key new points about MRE include (1) Alina's statement that "we an actually diagnose NASH" using MRE and MRI-PDFF, (2...2021-12-2433 min

Surfing the MASH TsunamiS2-E62.1 - SurfingNASH's 2021 NAFLD year-in-review Covers AI in HistopathologyThis conversation is part of SurfingNASH's 2021 NAFLD Year-In-Review. Dr. Mazen Noureddin, Director of the Fatty Liver Program at Cedars Sinai, Los Angeles, joins Louise Campbell and Roger Green to discuss advances in AI in histopathology.Mazen Noureddin notes that while non-invasive tests are important and likely to become more so over time, drug development today will need to rely on AI to interpret and ultimately improve histology reads. One benefit he notes is the ability of AI reads to reveal differences between cirrhosis patients in terms of percentage of liver that is F4 vs. F3. In one...2021-12-2332 min

Surfing the MASH TsunamiS2-E53 - SurfingNASH Previews AASLD 2021: the Digital Liver MeetingManal Abdelmalek, Ken Cusi and Jörn Schattenberg join Louise Campbell and Roger Green to discuss key presentations at AASLD 2021 and preview SurfingNASH's coverage of the event. This virtual meeting runs from November 12-15 and is scheduled on East Coast time.Highlights include:9:19 – Roger begins the conversation, by describing the AASLD program elements and what SurfingNASH will cover.10:46 – Manal Abdelmalek kicks us off by focusing on Dr. Neil Henderson’s Hans Popper (Basic State of Science) Lecture and the relevance his talk will have meaning for NAFLD and NASH.12:53 – Ken Cusi links this talk...2021-11-0449 min

Surfing the MASH TsunamiS2-E39 - Celebrating Two Milestones for SurfingNASH!Seven of our favorite Surfers join together to celebrate 20,000 Buzzsprout downloads and our one-year anniversary of moving to Buzzsprout.Louise Campbell and Roger Green interview Stephen Harrison, Donna Cryer, Naim Alkhouri, Ian Rowe and Jörn Schattenberg to discuss what we have experienced during the first year of SurfingNASH. Each participant reminisces on how they came to the podcast and their favorites memories of the first year, discusses how SurfingNASH brings value to the Fatty Liver community and discussed what they hope to see from the podcast in the year ahead. Equal parts intellectual, warm a...2021-07-2958 min

Surfing the MASH TsunamiS2-E23.1 - From the Fourth Global NASH Congress -- Diagnosing DiagnosticsThe SurfingNASH Team has curated over three hours of recordings from the Fourth Global NASH Congress to highlight pieces that discuss the current and future states of diagnostics in Fatty Liver disease. You will hear Manal Abdelmalek, Naim Alkhouri, Suneil Hosmane, Ian Rowe, Jörn Schattenberg, Louise Campbell and Roger Green sharing opinions and debating issues.Discussions about diagnostics ran through SurfingNASH's entire coverage of the Fourth Global NASH Congress. Listen here for some of the diagnostics highlights. The group discusses exciting new precision diagnostics, urine and breath-based biopsies, realistic expectations for diagnostics in market t...2021-05-0334 min

Surfing the MASH TsunamiS2 E10 — Before NASH-TAG, Conversations With Co-DirectorsNASH-TAG Co-directors Vlad Ratziu and Michael Charlton talk with Roger Green about the upcoming conference, after which Roger discusses the SurfingNASH coverage plan for NASH-TAG.If you listen to SurfingNASH, you already know exactly how Stephen Harrison feels about NASH-TAG and what lights him up about this year's agenda. Now, listen as two other co-directors, Vlad Ratziu and Michael Charlton, discuss how the meeting started, what makes it special and what they are looking forward to most in this year's event as they speak with Roger Green. Afterwards, Roger announces the SurfingNASH coverage p...2021-03-1140 min