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APS Publications Podcast
APS Publications PodcastInterorgan Insights: Modulation of AQP1 and TGFB1 to Disrupt BMP/TGF-β Signaling in Human Pulmonary Microvascular Endothelial CellsIn this podcast, coauthors Chrysi Keskinidou and Nikolaos S. Lotsio discuss their recently published research article, ‘Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells’. The article describes the authors' deep dive into the interactions between AQP1 and TGFB1 in human pulmonary vascular endothelial cells, and and provide a novel perspective on the interactions of the BMP/TGF-β signaling pathway.  Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells Chrysi Keskinidou, Nikolaos S. Lotsios, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Ioanna Dimopoulou, Anastasia Kotanido...
2026-02-1305 minBase by Base
Base by Base186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq study of nasal biopsies showing that persistent immune signaling—not residual virus—drives aberrant epithelial differentiation in people with post‑COVID syndrome. fileciteturn1file0 Study Highlights:Researchers profiled >56,000 cells from nasal tissue of individuals with moderate or severe post‑COVID syndrome, revealing marked depletion of proximal ciliated cells alongside expansion of basal and immune cell populations. Cell–cell communication and pathway analyses identified heightened TNFα and TGFβ signaling, with MIF–CD74 inter...
2025-11-0215 minCardiology Today
Cardiology TodayTGF-beta Blockade Prevents Heart Scarring? 09/20/25Welcome to Cardiology Today – Recorded September 20, 2025. This episode summarizes 5 key cardiology studies on topics like non-ST segment elevation acute coronary syndrome and machine learning. Key takeaway: TGF-beta Blockade Prevents Heart Scarring?. Article Links: Article 1: Fibroblast-Specific Loss of TGF-β Signaling Mediates Lipomatous Metaplasia in the Infarcted Heart. (Circulation) Article 2: Role of A2AR-D2R Dimerization and D2R-Biased Signaling in PDE10A-Mediated Cardiac Hypertrophy. (Circulation) Article 3: Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial. (European heart journal) Article 4: Postprocedural parenteral anticoagulation in patients with non-ST segment elevation acu...
2025-09-2000 minSome Videos
Some VideosTGF COOKING SHOW | TGF ReuploadTGF COOKING SHOW | TGF Reupload Guys, WE HIT IT! 5K OMG. No but seriously I never expected to even hit 1k on this channel, I originally started this channel as an experiment with upscale A.I, and from the instant support I got from these videos, I decided to carry on with the uploads, and look where we are today. 5k! I truly love every supporter on this channel, you are legends 😃 I originally uploaded this about 6 months ago, but the quality wasn't up to my standards, so I've re-upscaled it to a crisp 1080p-6...
2025-09-1100 minTGF presents: Dessert Island Discs
TGF presents: Dessert Island DiscsTGF Presents DID #3: IGT’s Jen Bowman gets ready for life in exileMeet Jen Bowman of IGT fame. Jen talks us through her choices to take to a deserted tropical island: 3 albums3 books3 movies 1 song1 pet1 object1 dessert…and one piece of advice to give her younger self. Have to say, this episode is completely worth it just for the pet part. Brilliant. Anyway, you can find the RSS for the offshoot here: https://feeds.captivate.fm/tgf-did/And it's available at all good podcast outlets. Probably the dodgy ones too. And if you have a guest suggestion, we are all ears. Fintan especially, that's why he...
2025-04-221h 21Cannabinoid and Psychedelic Pharmacology and Drug Development
Cannabinoid and Psychedelic Pharmacology and Drug Development90 Day Deep Dive Podcast Series into the World of Human Receptor Pharmacology - Day 37 TGF-beta Receptor Signaling MechanicsJoin us for a fascinating exploration of TGF-beta receptor signaling, where we break down the intricate cellular dance that determines cell fate. Discover how these molecular gatekeepers work together with their partners to control cell growth and death, and learn about the consequences when these precise systems go awry. From cancer to fibrosis, understand how tiny changes in these pathways can have profound effects on human health, and glimpse into the future of potential therapeutic interventions.
2025-02-0111 minCannabinoid and Psychedelic Pharmacology and Drug Development
Cannabinoid and Psychedelic Pharmacology and Drug Development90 Day Deep Dive Podcast Series into the World of Human Receptor Pharmacology - Day 36 TGF-beta Superfamily OverviewDive deep into the fascinating world of the TGF-beta superfamily, the tiny but mighty proteins that act as cellular puppet masters shaping tissue growth and maintaining bodily balance. This episode explores how these essential signaling molecules control everything from cell growth and development to immune responses, functioning like a precisely tuned system of brakes and accelerators. Learn how these remarkable proteins communicate between cells and maintain the delicate harmony of life itself, while also discovering what happens when these critical pathways go awry.
2025-02-0128 minCAMPO SUSTENTABLE
CAMPO SUSTENTABLEDESCUBRE CURICO : Hoy con THINK GOOD FOODS - TGF - Tú partner de la Idea a la MesaHoy estuvimos en una entretenida conversación con Cesar Quezada, Ingeniero en Alimentos, asociado y Director de DESCUBRE CURICÓ y nos contó de su empresa Think Good Foods (TGF) Consultora especializada en Ingeniería, Innovación y Gestión de Negocios en el rubro de Alimentos, con una visión desde la oportunidad para agregar valor comercial a los productos desarrollados, reduciendo la brecha entre una buena idea de innovación productiva y un buen negocio. Para los que quieran y necesiten agregar valor comercial a sus emprendimientos o empresas de alimentos contactar y visitar su página web. www.tgfco.cl...
2024-08-0735 minBlood Podcast
Blood PodcastMutational and transcriptional landscape of pediatric BCP lymphoblastic lymphoma; the role of platelet-derived TGF-1 in immune thrombocytopenia; phase 3 trial of mavorixafor in WHIM syndromeIn this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome.Featured Articles:Mutational and transcriptional landscape of pediatric B-cell precursor lymphoblastic lymphoma Platelet-derived TGF-β1 induces functional reprogramming of myeloid-derived suppressor cells in immune thrombocytopenia Phase 3 randomized trial of mavorixafor, CXCR4 antagonist, in WHIM syndrome 
2024-07-0423 minQuoi-de-neuf-Docteur
Quoi-de-neuf-DocteurInnovation thérapeutique dans l’HTAP : cibler la voie du TGF-beta.Innovation thérapeutique dans l’HTAP : cibler la voie du TGF-beta. Laurent Savale, Le Kremlin Bicetre, David Montani, Le Kremlin Bicetre. (GT CP2) Jeudi de la SPLF 6 juin 2024 © SPLF 2024 Quoi de neuf docteur permet aux médecins pneumologues, ou d’autres spécialités d’écouter un expert francophone parler d’un sujet pointu de pneumologie en 5 minutes.
2024-05-1300 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP014 - TGF - God - As per scientistPresenting...... EP014 - TGF - God - As per scientist Imagine if a world famous scientist pray to god for getting success on research proving "There is no god" What world famous scientists think about god Scientist.. their belief in god and lot more interesting stuffs... The Latest episode for your ears is now just a click away                                                                                      Here’s an episode that will keep you waiting for the next one. Tune in now!
2023-11-1207 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP013 - TGF - God - The 4th personPresenting...... EP013 - TGF - God - The 4th person Can we approach god with a rational view ? Lets try... Its time to explore god beyond emotion.. Also brief discussion with a guy on NO FAB The Latest episode for your ears is now just a click away                                                                                       Happy Listening As U Love , So U love and so..Lets Love , Universal #AsULove Pls like share & subscribe
2023-11-1110 minThe Cabral Concept
The Cabral Concept2724: Laser Hair Removal, Fiber Intake, Turmeric & Joint Pain, Ozone & Hydrogen Peroxide Therapy, Breast Implants, TGF Beta 1 (HouseCall)Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Cyn: Hello doctor Cabral! What are your thoughts on laser hair removal? Is it safe? thank you! Cyn   Greg: Hi Dr. Cabral, Thank you so much for all that you do. I am a student of all that you teach and I greatly appreciate all the time and effort you put in to doing the res...
2023-07-2215 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP012 - TGF - Life - Journey , Purpose , ObjectivePresenting...... EP012 - TGF - Life -  Journey , Purpose , Objective Now listen to a beautiful story similar to the baloon story.An Exciting adventure , Time bound Tasks , Scores & Penalities & lot more...Its time to travel with your ears...experience the thrills .. A Solo journey within The Latest episode for your ears is now just a click away                                                                                        Happy Listening Pls like share & subscribe
2023-07-1108 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP011 - TGF - Life - The 4 people & 3 common thingsPresenting...... EP011 - TGF - Life -  The 4 people & 3 common things We will be exploring: The 3 common things in the entire journey of life and the 4 common category of people ‍️‍️‍️‍️ An another dimension of an already known thing.. A change in perspective will change the understanding ....Its time to remember  the forgotton person in your life.... The Latest episode for your ears is now just a click away
2023-07-0909 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastIs It Worth The Grind?Host www.twitch.tv/gamestalive Guests www.twitch.tv/yourboyjammy www.twitch.tv/supermicron For bespoke custom graphics, visit our sponsor Button Press Graphics and quote WEARETGF25 for a massive 25% OFF https://twitter.com/ButtonPressG https://www.facebook.com/profile.php?id=100092549115145 https://www.etsy.com/uk/shop/ButtonPressGraphics?ref=l2-about-shopname https://www.youtube.com/channel/UCJdZupCUgMoICpm7E9Maafg --- Send in a voice message: https://podcasters.spotify.com/pod/show/wearetgf/message
2023-07-031h 24The God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP010 - TGF - Love - As U Love,So U Live ️Presenting...... EP010 - TGF - Love -  As U Love,So U Live ️ We will be exploring One of the hidden reason for all the so-called issues of this world The all new dimension to look at the open secret ‍️ A single one liner to experience the godliness ‍️in you in the very moment Along with a beautiful Dad and daugther story ‍‍ The Latest episode for your ears is now just a click away
2023-06-0112 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastAre You Following Your Dreams?Today's theme -- Dreams. Are you following your dreams? And do they differ from the dreams you had as a child? Today I was joined by my good friends Serzy & DevMarvel as we discussed our dreams and what they were, how they shaped us and what we are aiming for next. If you want to get in touch, email me at wearetgf@gmail.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/wearetgf/message
2023-05-291h 21The Keep \'Er Lit Podcast
The Keep 'Er Lit PodcastEXCITING ANNOUNCEMENT - WELCOME CAZ TO TEAM TGF!FOLLOW CAIREANN @CAZCOACHING APPLY TO WORK WITH TEAM TGF COACHING: CLICK HERE
2023-05-2423 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP009 - TGF - Self - know the "Unknown" gapPresenting...... EP009 - TGF - Self -  know the "Unknown" gap We will be exploring The basic question to ask yourself ? Reasons for the incomplete Sense of feeling And the variety of easiest "Match the following" to connect with day to day practical life The Latest episode for your ears is now just a click away                                                                                               Happy Listening Pls like share & subscribe
2023-05-2108 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP008 - TGF - Guru - Role & Dependency.Presenting...... EP008 - TGF - Guru -  Role & Dependency We will be exploring whether Guru is required? What should be the  role of a  Guru to start with ? Why people see guru as a  "Godman" ? Magics , Miracles & lot more The Latest episode for your ears is now just a click away                                                                                               Happy Listening Pls like share & sub
2023-05-0612 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastHappy Birthday Beat SaberWE ARE BACK! There has been a long wait because I have been setting up my own business, I am sorry about that but now we are back. What better way to bring back the podcast than on Beat Saber's Birthday. Today, on our Beat Saber themed podcast, I am joined by fellow Official Ambassadors for the game and a TOP10 player worldwide. We talk about what BS means to us, why we started playing and why we continue to do so all these years later.
2023-05-011h 41The God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP007 - TGF - God - Common PsychologyPresenting...... EP007 - TGF - God -  Common Psychology Why the concept of God has came up ? What could be the reason ? Those common phycology when it comes to god. Why the all goodness is mapped to god .. How PPL relate to god  n what defines the degree to experience And lots more.. The Latest episode for your ears is now just a click away                                                                                               Happy Listening Pls like share & subscribe
2023-04-2805 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP006 - TGF - Religion - Commons & QuestionsPresenting...... EP006 - TGF - Religion - Commons & Questions We will see A generic overview of religions Why religion here What to expect n what not to A rational approach And lots more... The Latest episode for your ears is now just a click away                                                                                              Happy Listening Pls like share and subscribe
2023-04-2105 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP005 - TGF - Thought - An energy journeyPresenting... EP005 - TGF - Thought - An energy journey Let's travel for sometime with our thoughts.. We will meet Harmones and Fate in between and land in emotions... And lots more.. A curious episode for your ears… The Latest episode for your ears is now just a click away                                                                                              Happy Listening Pls like share and subscribe "The God Factor" - A Happy Krishna Podcast
2023-04-1405 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP004 - TGF - Soul - A Scientific QuestPresenting... EP004 - TGF - Soul - A Scientific Quest The everlasting quest of science... Why this approach? Why you doing this ? How you gonna do this ? Decoding self And lots more.. A curious episode for your ears… The Latest episode for your ears is now just a click away                                                                                              Happy Listening Pls like share and subscribe "The God Factor" - A Happy Krishna Podcast
2023-04-0705 minThe God Factor - A Happy Krishna Podcast
The God Factor - A Happy Krishna PodcastEP003 - TGF - Identity - That One ThingPresenting... EP003 - TGF - Identity - That One Thing If you have the identity  , You are thinking You think  - You are thinking , But Is it really you or someone is thinking through you ?‍️ Who is in the last layer of that identity ?‍️ Is it you or someone else ? Is there anyone who is anchoring us from inside ?? Exploring the hidden layer within and lots more A curious episode for your ears… The Latest episode for your ears is now just a click away
2023-04-0104 minThe Geek Freaks Techcast Weekly
The Geek Freaks Techcast WeeklyEpisode 23 | Hausrenovierungen, TGF vs. Mifcom, Websiteoptimierungen und LangzeitprovisorienEpisode 23 des TGF Podcasts Teilnehmer: Themen: Raspberry Pi Pico auf AliExpress: https://de.aliexpress.com/item/1005005143535882.html Downloads:
2023-03-1956 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastThe Gaming Couples Of TGFWE ARE BACK! Hello my friends and welcome back to Season 3 of the We Are TGF Gaming Podcast. In todays episode, myself, Pixie, Mystic, Mrs. Mystic, SerzyDee & DevMarvel talk streaming, gaming and what it is like to have our respective better half supporting us along the journey. If you want to join our discord or check out any of us, simply follow the links below. Also, if you wish to get in touch, feel free to email wearetgf@gmail.com DISCORD https://discord.gg/vJcwER4K8B ...
2022-11-231h 45PharmaVibe
PharmaVibeThe First and Only TIGIT/TGFβ Bispecific Antibody Under Research in the WorldThe marketing approval of SinoCellTech's new anti-CD20 monoclonal antibody ripertamab aroused the attention of the industry in China this week. While the clinical trial application of the AK130 injection developed by another Chinese company Akeso was accepted, making it the first and the only TIGIT/TGFβ bispecific antibody under research in the world. Other pharma news collected this week features 26 pieces of information covering topics on drug review, R&D, business, and listing. You can get more industry insights and firsthand market information from China to the globe at PharmaSources.com
2022-09-0716 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastJRPGs Vs. RPGs - What's The Difference & Which Is Better?Today I am joined by TGF OG member VaPR M00RE aka JJ & oue European friend Supermicron. We discuss the differences between two genres and try to see which is better and why, if you have different thoughts to us, do not hesitate to get in touch and share this podcast if you enjoy it. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com Discord https://discord.gg...
2022-07-311h 36We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastLearn More About A Beat Saber DeveloperToday we were blessed to have Baty, the Beat Saber Dev in charge of social media, answer our questions. We got to know the lady behind the job and it was fascinating. Joining me today was SlayerFest, one of the greatest players on PSVR & someone I consider to be a great friend. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com Discord https://discord.gg/Db4vZm4Ne2
2022-07-151h 25朝まで勝手に勉強会（眼科の最新論文を紹介）
朝まで勝手に勉強会（眼科の最新論文を紹介）142回 網膜色素上皮細胞の上皮間葉転換における低酸素とTGFｂ２の関与についてInt J Mol Sciの2022年5月に掲載されたHypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cellsを読みました。https://pubmed.ncbi.nlm.nih.gov/35628282/
2022-07-0320 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastBehind The Seas, A Crew's InsightWhat sets some crews apart from others? Today we are joined by Empress_Cry55e, Aussie & Acrusurge - a crew that sail together regularly and work well together. Even Pro crews have a heard time taking these guys out and this is why. Get to know the people behind the crew and find out why they succeed. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com Discord https...
2022-07-011h 57We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSit Back, Relax & Enjoy PhuzzyBondToday I am very pleased to share with you an episode with the man behind the Sea Of Thieves Tutorials & 'feel good' streams over on Twitch. PhuzzyBond is a content creator, streamer & family man that I admire very much. In this episode we talk about everything to do with how he started to game, what his motivations are & what are his views on content creation as a whole. He even discusses his process for making a successful video or having a great stream. I am happy to report that Phuzzy really is as genuine to talk to...
2022-06-172h 09We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 13 - The Future Of GamingWelcome back to another episode of the We Are TGF Gaming Podcast. Today we have a returning guest in the form of Taylorpietersengaming aka TG Taylor. We discuss the new texhnology that will be coming in the future and how we think the gaming industry will change in the next 10-20 years. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message
2022-06-031h 49Traces, le podcast jeu vidéo
Traces, le podcast jeu vidéoAlexis TGF sur Ace Attorney, les visuals novels et la fan trad'Dans cet épisode de Traces, Alexis TGF nous décrit sa passion pour le visuel novel, son amour pour Ace Attorney et sa volonté de faire connaitre les jeux vidéos à un public qui ne le peut pas forcément. 00:00 : Présentation04:14 : Enfance17:10 : Ace Attorney24:12 : Psychologie dans le Visual Novel44:59 : Traduction anglaise et fan-traduction (et un peu de hors contexte) Chaine d'Alexis TGF :https://www.youtube.com/c/AlexisTGF
2022-05-311h 17We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 12 - Bubbles Has Returned!Hello you lovely lot and welcome back to another episode of the We Are TGF Podcast. Today the topic is genres of games and I am joined by the returning guest Bubbles. We talk about everything from mental health, Tourettes and of course gaming. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com ...
2022-05-132h 01We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 11 - It's All About The MechanicsHello my friends. In this episode, myself and two new friends (discovered on TIkTok) Chris & Jeff talk about the mechanics in games past & present. Of course, it wouldn't be a TGF podcast without us going off-topic a few times so you can expect things like gaming with PTSD, being able to save your games and what made us fall in love with gaming. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the...
2022-04-302h 37We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 10 - Then 'N' NowHello my friends. Today's topic is what have changed from the early games of gaming to present day. My guests are Mysticthegamer06 and SpeckyMcSporran.  In this episode we talk about older games and the difference to newer ones and cover things like UE5, the new Sonic 2 movie and a lot more besides. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/w...
2022-04-162h 42We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 9 - We Are Parent StreamersWE ARE BACK! Sorry for the long delay since the last episode. Find out why the delay happened by listening to the episode. Today, Thitherleech and myself go over the issues we face both being parents and content creators. It is a juggling act to be sure. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email...
2022-04-022h 11We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 8 - The Best Looking Guys On A PodcastHello my friends. The last episode uploaded with issues (that have now been fixed) hence the long wait until this one. Today I am joined by Psycho_Wayne & IDK_KillZz as we get to know them a little better and find out why they decided to game and why they became content creators. This is the place to be to find the undiscovered talent from Twitch. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor...
2022-02-232h 27We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 7- TGF Are Giving BackToday is a little bit different. Thitherleech, YourboyJammy, Jay_TTG & myself are coming together to raise money for Macmillan Cancer Research on the 27th Feb at 10am (BST/GMT) with a Game Heroes Charity Stream. ALL Proceeds raised will go to funding the selfless work that Macmillan do on a daily basis to help people effected by cancer. This episode delves into why we are doing this and why Macmillan is for me personally, an important charity that I want to support. There will be more streams in the future and I would love it if you...
2022-02-041h 24We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 6 - Brothers In GamingToday, me and Thitherleech talk about all things gaming from what we have been playing & the big news that Microsoft has bought Activision Blizzard to a 70 year old WoW player being unbanned. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com Discord https://discord.gg/Db4vZm4Ne2 Your Hosts: TGF_Gamesta aka Rob https://www.youtube.com/channel...
2022-01-261h 40We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 5 - Different Sides Of The PlanetWe finally did it!! We have finally managed to get the one and only TGF OG on the podcast that we haven't done since the beginning. Long time loyal listener ChillFungi is joining us on today's episode alongside Max Fogerty. Both of which are from Australia. It was an absolute pleasure talking to these two guys and about their loves and grievances when it comes to gaming. Subjects included sweats vs. casuals, handheld consoles, upcoming game releases, Dying Light 2's 500 hour playtime and much more. We discuss all things gaming and a little more besides. ...
2022-01-122h 37We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 4 - 3 Is Company But 6 Is A CrowdAs the saying goes - couples who game together, stay together. So today, it gives me great pleasure in introducing our biggest podcast episode yet. Including myself and Pixie, there are 6 people in this episode. Myself and Pixie hosting with our good friends VaPR_M00RE (JJ/JMoore) & EvanWilliams (Robot) with their retrospective partners Kiki and Desirae. We discuss all things gaming and a little more besides. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm...
2021-12-221h 59We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 3 - The Gaming Family RegularsToday we have two returning guests. My favourite streamer Thitherleech_316 & Mr Positive energy himself, Rahman. It is always a pleasure chatting to these two. Today we discuss things like Icarus, the new PSVR2 headset, Dead Space possibly going open world & much more. If you want to get in touch or join the TGF Discord you can do so by following the links below Voice Message https://anchor.fm/wearetgf/message Email wearetgf@gmail.com Discord https://discord.gg/Db4vZm4Ne2 Your Host: TGF_Gamesta aka Rob
2021-12-151h 41We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 2 - Waffling With The BoysIn today's episode I have the great pleasure of introducing 2 amazing members of The Gaming Family. Firstly, a long time member who remains an integral part of our community with his positive attitude, Rahman. Secondly, a newer member of the family from Denmark who is always happy to help those in need, Chemy_Dragonit. If you would like to be a guest during next season please get in touch. Simply email: wearetgf@gmail.com OR record a voice message that will be played during the episode by following this link https://anchor.fm/wearetgf/message ...
2021-12-012h 26We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastSeason 2 Episode 1 - We Are The Pirate Leg EndsWE ARE BACK!!! Hello my friends and welcome back to SEASON TWO of the We Are TGF Gaming Podcast. Last season we had over 610 listens and that has blown my mind. Thank you so much to everyone that has listened and even more to the people that have returned week after week. Thank you all so much. Now we are back with a brand new season and we are starting in style. From this season onwards you are going to hear episodes specific to certain games and this episode is all about Sea Of Thieves. ...
2021-11-242h 02We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 20 Toodles Season OneSo we have finally arrived at the last episode of the season. We will return in a couple of weeks or so with a brand new season of the We Are TGF gaming podcast so let me say that I have been overwhelmed with the amazing support that you have all given. Thank you for supporting the podcast and listening every week. Pixie & myself appreciate it more than you could know. If you would like to be a guest during next season please get in touch. Simply email: wearetgf@gmail.com OR record a voice message that...
2021-11-101h 33We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 19 - Look How Far We've ComeHello my gaming friends. Welcome to Episode 19 of the We Are TGF Gaming Podcast with...just us lol. Me & Pixie decided it was about time that we looked back on the TGF to talk about how far we have come, what has changed and how we feel about it. There will still be news stories including what games are due to release but this time, there will be no guests. Next week will also be the last episode in Season one of this podcast but we will be back very soon with a brand new season containing...
2021-11-031h 58We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 18 - Retro & Modern Gamers UniteHello you wonderful people & welcome back to the We Are TGF Gaming Podcast. Today I have great pleasure to introduce two returning guests in the form of Charlieb007 & YourBoyJammy Plus a new member of The Gaming Family that has a background in game development called FranklyFraz. In today's episode we talk about everything from JRPGs, Game development from the side of the developers right the way through to video game speed runners and a controversial patent filed by Sony. If you would like to be featured in our podcast by telling us a story, asking...
2021-10-273h 09We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 4 Welcome To The Doughnut BoxHello again you lovely lot, We Are TGF & we are back again with another episode of our podcast, thank you so much for joining us. In today's episode with have the special guest DoughnutDamage (one of Pixie's inspirations). He is a great streamer/content creator that I believe is destined for great things.  If you want to be a future guest, ask us or our guest(s) a question or simply tell us something, please email wearetgf@gmail.com If you wanna check out DD for yourself, copy and paste the links below i...
2021-10-211h 21We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 17 - Sea Of GamingHello my friends. Today we have the longest episode so far with out special guests Empress Chry55e & EvanWilliams aka Robot (Because he builds robots). Please Note Pixie was only present for half of this episode due to having the Covid-19 vaccine booster and the flu jab so she had to go to lay down. Remember, if you would like to get in touch with your gaming story, if you want to ask us & the guests a question or if you simply want to be considered as a guest for a future episode, get in touch by...
2021-10-203h 04We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 16 "I'm Not That Creative"Hello my friends. Today we bring to you, one of the OG members of the TGF...VaPR_M00RE aka JMOORE/JJ aka King Lurker (A name given to him due to the amount of time he spends lurking in multiple streams to show his support). This guy has been a BIG part of growing the TGF to what it is today and we feel blessed that he is part of it. In today's episode we talk about his loves, dislikes and why he streams along with discussing some news stories that have been happening within the gaming industry...
2021-10-131h 44We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 15 - Everyone Is FamilyHello my friends. Due to our planned guest having a family emergency, we have today got to brand new guests that we have been wanting on the podcast for a long while. Charlie007 (Previously Charlie666) & our Sweedish friend Jak9212. We already know them very well but it was nice to get to know them even better. NOTE We were trying out a new microphone for this episode and because it was not omnidirectional, there are times were Pixie was extremely quiet. I have tried to edit the audio the best that I can but unfortunately the quality is not...
2021-10-062h 18We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 14 The Student & The MasterHello again my wonderful friends. Thanks for joining us on another episode of the We Are TGF Gaming Podcast. Today, I have the pleasure of speaking with our returning guest, yourboyjammy & his chosen guest, CosmicBlueprint. I want to give a special thanks to Cosmic for getting up at 5:30am simply to record the podcast with us due to the time difference. It was amazing to me that one of our listeners believe in this podcast enough to do that and it was an absolute pleasure getting to know him better so thanks Cosmic. If you...
2021-09-292h 22We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 13 It's OK To Not Be OK...With 2!He has returned! The Mind Mental Health Charity streamer himself, Jay_TTG, has returned with the special guest & inspiration for doing charity streams, Kyle. It was an absolute pleasure getting to chat to Jay again & finally getting to chat to the person who inspired him to start streaming for Mind Mental Health. If you take nothing else away from this episode, I hope you understand that you are not alone. There are people out there, selfless people, like these two awesome people. Who will go out of their way to make sure that you are doing ok.
2021-09-222h 35We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 12 - We Finally Meet HerToday we present to you our good friend and his wonderful daughter. Mystic & Bubbles. It is always a pleasure getting to talk to Mystic and his daughter, despite the issues she has faced, is an absolute joy to talk to. If there is anything you are unaware of & that we don't cover, please do not hesitate to contact us. If you would like to get in touch to ask a question, tell us a story or simply to give feedback, you can do so by emailing us using this address: wearetgf@gmail.com - we read & reply...
2021-09-152h 00We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastTrailerPixie & my first trailer for our little podcast. An introduction to our gaming podcast. Feel free to get in touch with any feedback or questions wearetgf@gmail.com --- Send in a voice message: https://podcasters.spotify.com/pod/show/wearetgf/message
2021-09-0801 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 11 When A Noob Meets A ProWe are BACK! A brand new episode for your entertainment. Today, we are proud to welcome back our good friend Thitherleech_316 & new guest TJ the Splitgate Beast! It was a pleasure getting to know TJ more and of course it is always fun talking to Leech with the positive energy he brings. Longer episodes are also now going to be happening more as that has been requested from multiple listeners. If you would like to get in touch to ask a question, tell us a story or simply to give feedback, you can do so by emailing...
2021-09-082h 15We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 10 - The Fabulous FamilyWe Have Hit Our First Milestone! Hello again my friends. Thank you for joining us on this, the 10th episode of the We Are TGF gaming podcast. Let me take this opportunity to thank each and every one of you lovely lot for the AMAZING support coming back to listen to our little podcast every episode. It really does mean the world to Pixie & me. Today, as promised, is probably the most special guest to me personally as it is my own flesh & blood. My son Adam. It was an absolute pleasure to give an...
2021-09-011h 32We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 9 - "I Don't Know! Beast?"Hello my friends! We are back with another episode of our little gaming podcast. Thank you so much for joining us. Today we have two guests and the answers from a third so this episode is slightly longer than usual. Our guests today as as follows. TG Taylor Gaming - This young lad is a key member of TGF and has continued to support this community from the beginning so it is our pleasure to have him on the podcast after the multiple shoutouts he has had in previous episodes. Redandent - This guy is...
2021-08-252h 23We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 8 - We Are The Saber SquadHello you lovely lovely & welcome back to episode 8 of our little We Are TGF podcast. Today, you have a special episode where we have 2 guests live & a 3rd who sent his answers in. Those guests are Slayerfest AKA Toni, Wright Byrd & Dani_Coma. 3 of the best Beat Saber players on the planet right now. Links to their socials are below & I strongly suggest checking them out for yourself. Please follow the We Are TGF gaming podcast so you never miss an episode & remember a new one will go live every Wednesday to ease them...
2021-08-181h 44We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 7 - Making It Up As We Go AlongWelcoming to Episode 7 of our little gaming podcast where we talk about everything gaming. In today's episode we, Pixie & myself are getting to know mysticthegamer06's gaming a little better. If you want to check him out for yourself, follow the links below. To all the regular listeners, THANK YOU. Thanks for coming back week after week and listening to this podcast. We are gaining more listeners with every episode and we appreciate every one of you. If you want to get in touch, to tell us your gaming stories, ask a question or to...
2021-08-111h 48We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 6 - It's OK To Not Be OKHello my friends, we are back with another episode of the We Are TGF Gaming Podcast. Today's special guest is The Gaming Family's 1st ever charity streamer on the Podcast. His name is Jay_TTG & he donates all the proceeds from his streams to mental health charities. It was a pleasure to hear why he does it & to get to know him better. All his links, along with the shoutouts are below. If you want to be featured on next weeks episode or want to be considered as a guest, please email us direct here...
2021-08-041h 34We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 5 - Double TroubleWe are not just gamers, we are The Gaming Family Soooo. Today was supposed to be with Redandent but unfortunately, his internet was being temperamental so we had to rearrange for another time. Fortunately, today we had two previous guests step in at short notice. ThitherLeech_316 & YourBoyJammy. We talk about the new gaming stories including Dead Space (of course lol), BF 2042 Portal, the Activision Blizzard lawsuit & more. To get in touch with me, Pixieness or to ask if you can be a guest, get in touch by email - wearetgf...
2021-07-2859 minWe Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 3 Can I Get A...Another episode of our little gaming podcast hosted by myself, Gamesta, & my wonderful lady, thepixiness. This time with our guest ThitherLeech. If you have any feedback, questions, topics or anything to say, you can email us & may be mentioned on next weeks podcast. Here is the email address you need ---> wearetgf@gmail.com  Alternatively, join The Gaming Family Discord server here ---> https://discord.gg/4ssJgnfxpt If you're interested in checking Leech out, all the info is below. Twitch - https://www.twitch.tv/thitherleech_316 T...
2021-07-141h 36We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastEpisode 2 It's Your BoyHello and welcome to episode two of the We Are TGF Podcast. Today we have our first guest, YourBoyJammy, a young up-and-coming content creator, streamer & all-round nice guy. check him out by following the links below: https://www.twitch.tv/yourboyjammy https://www.youtube.com/channel/UCis1QU5P3bASl24otIdBf3A https://twitter.com/yourboyjammy If you like the podcast, consider following so you will be notified as every episode uploads. You can join The Gaming Family Discord & stay upto date by following me, Gamesta, on twitter. The...
2021-07-071h 19We Are TGF - The Gaming Family Podcast
We Are TGF - The Gaming Family PodcastWe Are TGF & This Is UsWelcome to the We Are TGF (The Gaming Family) podcast. The podcast hosted by me, Gamesta aka Rob. I am a content creator, streamer, father & the co-founder of The Gaming Family: A community of video game fans who don't care about your race, colour, sexuality, age, size, sex or anything else. We come together through a mutual love of gaming. This is the podcast that discusses gaming with guests and hopefully has a giggle along the way. If you want to get in touch feel free to email this address - wearetgf@gmail.com - All feedback...
2021-06-301h 13ANTISOCIAL
ANTISOCIALLouis Wright | Joining TGF, Meeting Jay Swingler, Music + more... | ASP #36In today's podcast we have Louis Wright from TGF on, where we talk about growing up, toxic relationships, talk about his journey into YouTube as well as the interesting story of how he met the Jay Swingler and Romell from TGF and how he got involved with the boys. We also talk about his new song coming out as well as his music journey.
2021-05-311h 41The Scratched Record Podcast
The Scratched Record Podcast“FROM TGF TO POP PUNK?!” || LOU Interview || S02. EP12You know Louis from TGF? Yeah he makes pop punk indie bangers... who knew? Well we did, so we got him on! We discussed all things Lou, from school bullies to developing one of the best and most unique pop punk sounds we have ever heard! Of course we cover TGF and how he joined, which is actually an inspirational story about taking risks and believing in yourself. We get insight into being an influencer and a TikTok star, before doing a TGF scenario game special! Of course we shout out some up and coming artists - Daniel Briskin...
2021-04-131h 17Bootleggers Buzzcast
Bootleggers BuzzcastR10 E11: TI vs TGF! Why?Join Coastie, Himmel, and CMurder as we sit down to discuss the war between The Untouchables/The Gambino Family and The Invisibles/The Royal Family. More specifically, the feud between TI and TGF. We take a sneak-peak behind the scenes of this war, its origins, their perspectives on who is currently winning, and how they see it culminating in the end. Things get a little tense but everyone was able to remain civil, thankfully. Tune in to see for yourself! 
2021-02-0118 minUnder the Mask
Under the MaskTalking about helping TGF, and getting expelled from schoolIn today’s episode Ted and PP talk to farmer chap Ned Burton, about helping TGF out with there latest video, how he got expelled from school by the headmaster, and why the vegan community hates him!! - Ep 7
2020-12-1327 minThe Gulmohar Foundation
The Gulmohar FoundationNithin Lalachan - Volunteer stories in times of COVID-19 - Episode 6Hear the inspiring story of Nithin Lalachan, TGF Idukki
2020-09-1732 minThe Gulmohar Foundation
The Gulmohar FoundationSiva Mohan - Volunteer stories in times of COVID 9 - Episode 5Hear the story of Siva Mohan, TGF Alappuzha
2020-09-0948 minThe Gulmohar Foundation
The Gulmohar FoundationMubarakh Moosa - Volunteer stories in times of COVID-19 - Episode 4Hear the inspiring story of Mubrakh Moosa, TGF Kozhikode
2020-08-1934 minThe Gulmohar Foundation
The Gulmohar FoundationAyiba Khadeeja - Volunteer stories in times of COVID-19 - Episode 3Hear the story of Ayiba Khadeeja, TGF Kozhikode.
2020-07-1435 minThe Gulmohar Foundation
The Gulmohar FoundationAbhijith B Raj -Volunteer stories in times of COVID-19 - Episode 2Hear the inspiring story of Abhijith B Raj, TGF Kollam
2020-07-0131 minThe Gulmohar Foundation
The Gulmohar FoundationThufail - Volunteer stories in times of COVID-19 - Episode 1Hear the story of Thufail, from TGF Kozhikode.
2020-06-1916 minThe Gulmohar Foundation
The Gulmohar FoundationI have an idea!If you have an idea, then hear how The Gulmohar Foundation can help you.
2020-06-1606 minThe Gulmohar Foundation
The Gulmohar FoundationHow to get involved?Hear the podcast to know how you can involve in the activities of The Gulmohar Foundation.
2020-06-1612 minThe Gulmohar Foundation
The Gulmohar FoundationHow TGF work?Hear and know the actions of The Gulmohar Foundation.
2020-06-1614 minThe Gulmohar Foundation
The Gulmohar FoundationValuesUnderstand more about the values of The Gulmohar Foundation.
2020-06-1605 minThe Gulmohar Foundation
The Gulmohar FoundationIntervention ThemesLearn more about the Intervention Themes of The Gulmohar Foundation.
2020-06-1614 minThe Gulmohar Foundation
The Gulmohar FoundationVision & MissionKnow the Vision and Mission of The Gulmohar Foundation.
2020-06-1606 minThe Makeshift Pod
The Makeshift PodOUR PROBLEM WITH TGF BRO...SPOILER ALERT! We cover Rick's last episode in The Walking Dead, TGF Bro's trading cards and serving a celebrity at work... but that's not all! Sit back relax and enjoy this episode of the Makeshift Pod!
2018-11-061h 00The Greater Fools
The Greater FoolsIs BaneCat The Best Movie Villain? - TGF Ep. 10Is BaneCat the Best Movie Villain? - TGF Ep. 10 Looking back at all the movies we've watched in our lives, it's hard to place the exact moment you realized the villain makes the movie. On this weeks episode, our OG Fools, Chris Gibbs, Mike Brazell, Adam Aldous, and Sam Wilkinson, discuss the best movie villains and what made them truly memorable antitheses of our heroes. We talk about antiheroes and why we love to follow their stories. Then we cap things off with a discussion of the characteristics of a perfect villain which I think you'll agree, is BaneCat. No...
2018-07-171h 14The Greater Fools
The Greater FoolsWe Want S'Moore's Law - TGF Ep. 7We Want S'Moore's Law - Ep. 7 - The Greater Fools On this episode of TGF, we're talking about exponential growth. We start with the crazy concept one of the co-founders of Intel discovered (Moore's Law), and we chase that idea of exponential growth in technology down the rabbit hole. We talk how it has affected our lives, and where that concept takes us into the future. Then we branch out and talk about exponential growth in other industries other than tech. As with a few of our episodes, we are talking about something that we barely understand, so if you're...
2018-06-1954 minFakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 05/06
Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 05/06Involvement of latent TGF-beta binding protein 1 in CADASIL-relevant Notch3 aggregationCADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) represents the most prevalent hereditary form of cerebral small vessel disease (SVD) resulting in early-onset stroke and vascular dementia. It is caused by stereotyped missense mutations in the transmembrane receptor Notch3, which alter the number of cysteine residues in the extracellular domain (ECD). This leads to the abnormal multimerization and extracellular deposition of mutant Notch3-ECD at the plasma membrane of smooth muscle cells in small blood vessels. Notch3-ECD-containing aggregates are the earliest manifestation of the disease and excess Notch3-ECD is believed to recruit functionally important extracellular matrix...
2014-12-0800 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 17/19
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 17/19Selektive Zelloberflächenmodulation von Nierenzellkarzinomen mit Glykosylphosphatidylinositol-verankertem TIMP-1 hemmt die TGF-β1-Aktivierung und senkt die Expression regulatorischer ID-GeneDas zugunsten von Matrix Metalloproteinasen (MMP) verschobene Proteasen/Inhibitoren-Verhältnis begründet unter anderem die Malignität von Nierenzellkarzinomen. „Tissue Inhibitor of Metalloproteinases 1“ (TIMP-1), ein löslicher Gewebeinhibitor für Metalloproteinasen der extrazellulären Matrix, kontrolliert die Aktivität von MMP durch 1:1 stochiometrische Bindung. Durch Fusion von humanen TIMP-1 mit einem Glykosylphosphatidylinositol- (GPI-)Anker wird die TIMP-1-Aktivität von der extrazellulären Matrix auf die Zelloberfläche verschoben und eine lokale Applikation von definierten TIMP-1-Konzentrationen ermöglicht. Mit TIMP-1-GPI behandelte Nierenkarzinomzellen zeigten im Vergleich zu Vehikel und nativen TIMP-1-Kontrollgruppen signifikant erhöhte Apoptose- und reduzierte Proliferationsraten. Ziel der Arbeit...
2014-10-0200 minMedizin - Open Access LMU - Teil 22/22
Medizin - Open Access LMU - Teil 22/22Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD depositsCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) represents the most common hereditary form of cerebral small vessel disease characterized by early-onset stroke and premature dementia. It is caused by mutations in the transmembrane receptor Notch3, which promote the aggregation and accumulation of the Notch3 extracellular domain (Notch3-ECD) within blood vessel walls. This process is believed to mediate the abnormal recruitment and dysregulation of additional factors including extracellular matrix (ECM) proteins resulting in brain vessel dysfunction. Based on recent evidence indicating a role for the transforming growth factor-β (TGF-β) pathway in sporadic and familial small vessel disease we...
2014-01-0100 minMedizin - Open Access LMU - Teil 20/22
Medizin - Open Access LMU - Teil 20/22TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patientsSystemic sclerosis (SSc)-related pulmonary arterial hypertension (PAH) has emerged as a major mortality prognostic factor. Mutations of transforming growth factor beta (TGFβ) receptor genes strongly contribute to idiopathic and familial PAH.
2012-11-0100 minMedizin - Open Access LMU - Teil 20/22
Medizin - Open Access LMU - Teil 20/22TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patientsSystemic sclerosis (SSc)-related pulmonary arterial hypertension (PAH) has emerged as a major mortality prognostic factor. Mutations of transforming growth factor beta (TGFβ) receptor genes strongly contribute to idiopathic and familial PAH.
2012-11-0100 minMedizin - Open Access LMU - Teil 20/22
Medizin - Open Access LMU - Teil 20/22Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-β1 activation and reduces regulatory ID gene expressionTissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1–GPI) shifts the activity of TIMP-1 from the extracellular matrix to the cell surface. TIMP-1–GPI treated renal cell carcinoma cells show increased apoptosis and reduced proliferation. Transcriptomic profiling and regulatory pathway mapping were used to identify the potential mechanisms driving these effects. Significant changes in the DNA binding inhibitors, TGF-β1/SMAD and BMP pathways resulted from TIMP-1–GPI treatment. These events were linked to reduced TGF-β1 signaling mediated by inhibition of proteolytic processing of latent TGF-β1 by TIMP-1–GPI.
2012-01-0100 minMedizin - Open Access LMU - Teil 19/22
Medizin - Open Access LMU - Teil 19/22TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic AcidBackground/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the...
2012-01-0100 minSIBBM 2011 Frontiers in Molecular Biology
SIBBM 2011 Frontiers in Molecular BiologyS. Piccolo - TGF-beta signaling in development and cancerStefano Piccolo, University of Padua, Padua - Italy speaks on "TGF-beta signaling in development and cancer". This seminar has been recorded at University of Trieste by ICGEB Trieste
2011-05-2748 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 08/19
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 08/19The Role of bFGF, IGF-I, PDGF and TGF-ß in the Expression of the Osteogenic Phenotype in Human Marrow-Derived Bone-Like Cells In CultureExtensive studies have shown that undifferentiated cellular components of human bone marow are involved in the formation and renewal of bone tissue (osteogenic cascade). In this study, human mesenchymal stem cells were stimulated by bFGF, IGFI, PDGF-BB or TGF-ß1, in 2 different concentrations respectively (1 and 10 µg/mL). in vitro to assess their influence on differentiation to the osteoblastic phenotype. Thus human marrow could be used as a malleable basic element in bone engineering. The study clearly showed a stimulatory or suppressive effect of each of the respective growth factors. In particular the addition of TGF-ß1 directed the differentiation of mesenchymal stem cel...
2008-05-0800 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 06/19Expression und Funktion der TGF-Beta-Isoformen in HypophysentumorzellenIn dieser Arbeit soll eine Dysregulation der an der Angiogenese beteiligten TGF-Beta-Isoformen und ihrer Rezeptoren in Hypophysentumorzellen als möglichen pathogenetischen Faktor in der Tumorentstehung bzw. -progression von Hypophysenadenomen dargestellt werden.
2007-03-0800 minMedizin - Open Access LMU - Teil 09/22
Medizin - Open Access LMU - Teil 09/22Modulation of Schwann cell phenotype by TGF-beta1The phenotype of a fully differentiated, mature Schwann cell is appar-ently largely determined by Schwann cell-axon interactions. In vitro, elevation of intra-cellular cAMP levels in Schwann cells induces a phenotype which resembles that of a mature, i.e., axon-related, Schwann cell. Therefore, an important role for cAMP as a second messenger of axon-Schwann cell interactions in vivo is assumed. However, the effects of cAMP on Schwann cells are not restricted to induction of features of a mature phenotype. For example, elevation of intracellular cAMP levels results of also in a markedly increased synthesis of nerve growth factor (NGF) mRNA, which...
1992-11-1200 min