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Copernicus AI PodcastCRISPR EpigenomeEpisode Description:
Episode Overview
In this episode of Frontiers of Research, host Antoni explores the revolutionary field of CRISPR epigenome editing with experts Dr. Sarah Chen and Dr. Josh Patel. They discuss how CRISPR technology is being adapted to modify epigenetic marks without changing the underlying DNA sequence, opening new possibilities for treating genetic diseases and understanding gene regulation.
Key Topics
The evolution of CRISPR from DNA editing to epigenome modification
dCas9 and other catalytically inactive Cas proteins for targeted epigenetic editing
Applications in treating genetic diseases through epigenetic reprogramming
Challenges in...2025-07-2804 min
BioBits & BytesCRISPR 3.0 : Gene Control Beyond Editing🎙️ Welcome to BioBits and Bytes!In this episode, we're diving into the cutting edge of gene editing with CRISPR 3.0 — the next generation of precision biotechnology that’s rewriting the rules of life science. 🧬✨From its humble beginnings as a bacterial defense system, CRISPR has rapidly evolved. First came CRISPR 1.0, enabling targeted DNA editing. Then CRISPR 2.0 introduced base editing and RNA-targeting tools. Now, with CRISPR 3.0, we're witnessing a revolution in how we program biology — with more precision, control, and therapeutic potential than ever before.In this episode, you’ll learn:2025-06-3046 min
Plutopia News NetworkNeal Baer: The Promise and Peril of CRISPRIn this wide-ranging Plutopia podcast episode, Dr. Neil Baer — television writer and producer, physician, and public health advocate — discusses The Promise and Peril of CRISPR, a book he edited that explores the ethical, medical, and social implications of gene editing. While CRISPR holds transformative potential to cure diseases like sickle cell anemia and beta thalassemia, Baer warns of a slippery slope when it comes to altering human embryos, raising difficult questions about disability, human variation, and who decides what traits are worth preserving. The conversation touches on potential abuses such as eugenics, designer soldiers, bioterrorism, and corporate exploitation, while also...2025-06-021h 07
Plutopia News NetworkNeal Baer: The Promise and Peril of CRISPRIn this wide-ranging Plutopia podcast episode, Dr. Neil Baer — television writer and producer, physician, and public health advocate — discusses The Promise and Peril of CRISPR, a book he edited that explores the ethical, medical, and social implications of gene editing. While CRISPR holds transformative potential to cure diseases like sickle cell anemia and beta thalassemia, Baer warns of a slippery slope when it comes to altering human embryos, raising difficult questions about disability, human variation, and who decides what traits are worth preserving. The conversation touches on potential abuses such as eugenics, designer soldiers, bioterrorism, and corporate exploitation, while also...2025-06-021h 07
DrMcPharmaEp. 6. CRISPR: Bacterial Oddity to Gene Editing RevolutionThe History of CRISPR: From Discovery to Therapeutic DevelopmentClustered Regularly Interspaced Short Palindromic Repeats (CRISPR) have emerged as a revolutionary gene-editing technology, fundamentally altering the landscape of biological research and opening unprecedented avenues for therapeutic development. This technology, initially a curious observation within the genomes of bacteria, has undergone a remarkable journey to become a Nobel Prize-winning tool with the potential to address a vast spectrum of human diseases.The journey of CRISPR from an obscure observation in bacterial genomes to a revolutionary tool in medicine is a...2025-05-1822 min
Science and Spirituality for the CuriousEp 1.4: Genetics, CRISPR, Ethics, and SpiritualitySend us a textIn this episode, Richard explores the ethical challenges and spiritual questions raised by the new CRISPR technology with Dr. Marnie Gelbart, who is Director of Programs at the Harvard Medical School’s Personal Genetics Education & Dialogue Program (PGED). Richard began with an overview of CRISPR technology, emphasizing its precision and potential cost-effectiveness. He emphasized that, in germline applications, CRISPR could potentially allow humans to control their own evolution. Richard also described the potential benefits of CRISPR in agriculture, medicine, and the environment. He discussed the recent success of Colossal Bioscienc...2025-05-0539 min
生物解码BioDecoderE4 拿什么拯救你，CRISPR：技术瓶颈，资本困局和伦理危机全球首个CRISPR基因疗法终于获批，为何市场却反应冷淡？定价220万美元，到底谁来买单？如此高昂的基因疗法，该如何降低成本？曾经被欢呼的‘基因剪刀’，为何仍在商业化路上步履维艰？我们离CRISPR治愈疾病的预言，还相差多久？人类又是否能够在技术成熟之前，保住自己的道德资本？本期节目将深入探讨CRISPR技术的现实挑战：从Casgevy治疗的复杂流程，到美国碎片化医保体系如何阻碍天价疗法的覆盖；从科学家如何努力降低脱靶风险和治疗成本，到基因编辑是否正在模糊治疗与强化的界限。我们将会从科研人的视角解析：CRISPR能否跨越科学与商业的鸿沟？人类又该如何驾驭这把“上帝剪刀”？ (02:50) 基因编辑的里程碑：首款疗法casgevy的商业化之路为何重重受阻 (08:40) Caribou的RNA-DNA嵌合系统：能否解决脱靶风险？ (13:24) 碱基编辑是否能扭转乾坤？谁更接近“安全编辑”？ (20:44) ZFN编辑技术过时了吗？对比CRISPR的竞争优势 (23:45) CRISPR的优势也在于代码开源的open science精神 (26:10) 220万美元定价的逻辑：成本、支付模式与市场萎缩 (34:24) 绕不过的递送？CRISPR在CAR-T细胞疗法中的应用与前景展望 (41:14) 突破监管枷锁：创新审批模式可显著降低CRISPR成本 (43:46) 基因编辑的伦理界限：医学治疗还是“定制婴儿”？ (51:32) 如果基因编辑创造了一个乌托邦，人类文明将何去何从 (53:26) 从刘慈欣的《时间移民》到 基因编辑带来的《完美世界》👥 本期嘉宾介绍🔬 可思叮系统生物学博士，专注于高通量组学与疾病机制解析。目前在湾区一家生物技术公司从事科研工作，热衷于利用大数据解决生物医学难题。🧠 小水博士博士后研究员，研究神经退行性疾病中的细胞死亡机制，擅长干细胞类器官建模与活细胞成像。最近开始深度研究 AI 在生物医学中的应用。🧬 小橙生物物理学博士，专注蛋白质与小分子相互作用。目前致力于蛋白降解剂的开发，希望推动AI在临床医学中的应用。🧪 JK癌症生物学博士，目前专注基因编辑技术与新型癌症疗法，致力于开发更精准的生物医药工具。2025-04-141h 00
blaubiologie - Analysen und Trends für die Biotech- und PharmaindustrieCRISPR im klinischen KontextVon Casgevy bis Cas3 – wie CRISPR die Medizin verändertDie Entdeckung und Weiterentwicklung der CRISPR-Technologie hat das Feld der Genomeditierung grundlegend verändert. Ursprünglich als adaptives Immunsystem von Bakterien identifiziert, wurde das CRISPR/Cas-System in den letzten Jahren zu einem der mächtigsten Werkzeuge in der molekularbiologischen Forschung und Medizin. Mit seiner Präzision und Flexibilität hat es Anwendungen in der Grundlagenforschung, in der Entwicklung neuer Therapien für genetische Erkrankungen und in der Landwirtschaft gefunden.Neben CRISPR existieren weitere Werkzeuge zur gezielten Veränderung des Erbguts. Vor der Verbreitun...2025-04-0438 min
High StrangenessEp60 High Strangeness- CrispR- Editing Humanity with Kevin DaviesThe CRISPR Revolution: Unveiling the Future of Gene Editing In this episode of High Strangeness, host Tony discusses the revolutionary gene-editing technology CRISPR with Kevin Davis, a renowned science journalist and author of 'Editing Humanity.' They explore the advancements in CRISPR technology and its applications in healthcare, genetic disease treatment, and agriculture. The conversation delves into the origins and development of CRISPR, significant breakthroughs, ethical considerations, and potential future implications. Kevin also shares insights from his extensive research and highlights the impact of CRISPR on global science and innovation. 00:00 Introduction to High Str...2025-01-281h 21
MetaVida5. CRISPR, editando el futuro de la GenéticaEn el emocionante episodio titulado "CRISPR: Editando el futuro de la genética" de MetaVida, los anfitriones exploran la revolucionaria tecnología CRISPR-Cas9, que permite editar genes con una precisión sin precedentes. La conversación comienza con la historia de su descubrimiento, que se remonta a un microbiólogo español, Francisco Juan Martínez Mojica, quien, en las salinas de Santa Pola, identificó secuencias repetidas en microorganismos que formarían la base de esta innovadora herramienta.
Las anfitrionas explican cómo Jennifer Doudna y Emmanuelle Charpentier llevaron este hallazgo a un nuevo nivel en 2012, demostrando que CRISPR po...2024-10-2912 min
The Peter Attia DriveCRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D. View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Feng Zhang, a professor of neuroscience at MIT and a pioneering figure in gene editing, joins Peter to discuss his groundbreaking work in CRISPR technology, as well as his early contributions to optogenetics. In this episode, they explore the origins of CRISPR and the revolutionary advancements that have transformed the field of gene editing. Feng delves into the practical applications of CRISPR for treating genetic diseases, the importance of delivery me...2024-10-282h 05
AUTM on the AirInside the CRISPR Patent Wars: Innovation, Rights, and Legal Battles with Dr. Kevin NoonanIn recent years, CRISPR technology has emerged as a game-changer in the world of gene editing, unlocking remarkable possibilities across various sectors, including healthcare, agriculture, and environmental science.But what is CRISPR? CRISPR stands for "Clustered Regularly Interspaced Short Palindromic Repeats" and is based on an ancient function of prokaryotes—single-celled organisms such as bacteria and archaea. These organisms use a specialized CRISPR-associated molecule, Cas, to cut and destroy the DNA of invading viruses called bacteriophages. The CRISPR-Cas system has been engineered to work in eukaryotes, like animals and plants. Its ability to make precise, tar...2024-10-2354 min
Myth of the 20th CenturyEditing Humanity - Part II - American Genomics and the Truth about CRISPR (Myth20c - Ep276)Recently we spoke with Corey from the Stone Choir podcast to talk about the moral, legal and societal ramifications of the CRISPR gene editing technology. Tonight we are honored to have a genetic researcher offer his technical expertise and experience with the inner workings of the biotechnology field, including areas ranging from the increasing computational demands of molecule discovery to the political and financial dynamics of the varied research groups involved in the ever growing search for biological improvements and cures. With this as a backdrop, we compare the institutional quality of the United States, Europe, and Asia, and...2024-09-131h 15
Redefining Society and Technology PodcastBook | The Promise and Peril of CRISPR | Exploring the Intricate Relationship Between Healthcare, Technology, Ethics, and Society with Dr. Neal Baer | Redefining Society with Marco CiappelliGuest: ✨ Dr. Neal Baer, Co-Director, Master's Degree Program in Media, Medicine, and Health, Harvard Medical SchoolOn LinkedIn | https://www.linkedin.com/in/neal-baer/On Twitter | https://x.com/NealBaerOn Facebook | https://www.facebook.com/neal.baer.75/On Instagram | https://www.instagram.com/nealbaer/____________________________Host: Marco Ciappelli, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining Society PodcastOn ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/marco-ciappelli_____________________________This Episode’s SponsorsBlackCloak 👉 https://itspm.ag/itspbcwebBugcrowd 👉 https://itspm.ag/itspbgc...2024-08-3141 min
ITSPmagazine PodcastsBook | The Promise and Peril of CRISPR | Exploring the Intricate Relationship Between Healthcare, Technology, Ethics, and Society with Dr. Neal Baer | Redefining Society with Marco CiappelliGuest: ✨ Dr. Neal Baer, Co-Director, Master's Degree Program in Media, Medicine, and Health, Harvard Medical SchoolOn LinkedIn | https://www.linkedin.com/in/neal-baer/On Twitter | https://x.com/NealBaerOn Facebook | https://www.facebook.com/neal.baer.75/On Instagram | https://www.instagram.com/nealbaer/____________________________Host: Marco Ciappelli, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining Society PodcastOn ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/marco-ciappelli_____________________________This Episode’s SponsorsBlackCloak 👉 https://itspm.ag/itspbcwebBugcrowd 👉 https://itspm.ag/itspbgc...2024-08-3141 min
We Love ScienceEp 55: CRISPR Food ScienceSend us a textIn the Season 3 finale, We Love Science presents a special episode ALL ABOUT FOOD!! Specifically, we discuss how CRISPR gene editing technology is being used to improve our food and agricultural industry. Gene editing in plants has two main goals. The first goal satisfies consumer preferences for food enjoyment, like improved taste and freshness. The second category of food edits is aimed at solving food supply issues and the growing food insecurity. To this end, researchers have targeted agricultural traits for improvement. CRISPR gene editing has also been used...2024-07-2934 min
We Love ScienceEp 53: Safety and Ethics in a CRISPR WorldSend us a textIn this episode of "We Love Science," hosts Shekerah and Fatu delve into the safety and ethical considerations surrounding CRISPR gene editing technology. Joined by special guest, Irina Gostimskaya, we explore the complexities and implications of advances in biomedical technology, including the use of CRISPR in humans. The main purpose of ethical guidelines in biomedicine is to protect patients and ensure responsible scientific conduct. Past abuses of biomedical technology including inhumane medical experiments set the stage for modern bioethics. Key moments that shaped current ethical guidelines include: the 1947 Nuremberg Code developed a...2024-07-0148 min
Empowered Patient PodcastUnlocking the Power of CRISPR Technology for Drug Development with Ross Bundy CRISPR QC TRANSCRIPT Ross Bundy, President and CEO of CRISPR QC, shines a light on the current state of CRISPR gene editing technology and how the field has advanced rapidly since the discovery of CRISPR's potential to edit the human genome. The focus of CRISPR technology has primarily been on curing rare and genetic diseases, but there is also potential for targeting cancer tumors' resistance to chemotherapy and the development of customized therapies for various indications. The services offered by CRISPR QC include a unique sensor platform and data analytics capability to monitor and control the gene editing process. The company aims...2024-06-1100 minEmpowered Patient PodcastUnlocking the Power of CRISPR Technology for Drug Development with Ross Bundy CRISPR QC Ross Bundy, President and CEO of CRISPR QC, shines a light on the current state of CRISPR gene editing technology and how the field has advanced rapidly since the discovery of CRISPR's potential to edit the human genome. The focus of CRISPR technology has primarily been on curing rare and genetic diseases, but there is also potential for targeting cancer tumors' resistance to chemotherapy and the development of customized therapies for various indications. The services offered by CRISPR QC include a unique sensor platform and data analytics capability to monitor and control the gene editing process. The company aims...2024-06-1119 min
Thrilling Threads - Conspiracy Theories, Strange Phenomena, Unsolved Mysteries, etc!Hacking Life: CRISPR - Changing Lives or Creating Monsters?Unraveling CRISPR and the Future of Genetic EditingIn this captivating episode, join us as we venture into the mind-blowing realm of CRISPR technology, a true game-changer in the field of science. Get ready to unlock the secrets of this revolutionary technology and its staggering potential to rewrite the very code of life itself.Discover the fascinating story behind CRISPR, its origins, and how it works at a molecular level. We'll delve into the groundbreaking applications of CRISPR, from healthcare advancements to solving world hunger and environmental challenges.Join us as we explore the ethical...2024-06-0609 min
We Love ScienceEp 50: Changing Lives by the Million - CRISPR CuresSend us a textWe Love Science podcast celebrates our 50th episode with a discussion all about the hopes and progress of CRISPR clinical trials. Before a new drug, therapy, vaccine, or medical device is approved for general use by the public, its safety and effectiveness are evaluated in a series of tests on volunteers. These Clinical Trials progress in 3 successive phases with each phase designed to answer specific questions about the product under evaluation. Questions can include: What side effects does it cause? What is the lowest effective dose? What is the highest safe dose? Does...2024-05-2039 min
DNA Today: A Genetics Podcast#289 CRISPR Cured Victoria Gray’s Sickle Cell: Part 2Victoria is a patient advocate and international speaker from Mississippi. She is also a wife and mother of four children. Since being treated with CRISPR she has been featured in nearly every major publication including PBS, NPR, Forbes, Good Morning America, New York Times, and more.
In the first part of our conversation she shared about her experiences prior to being cured including her sickle cell pain crisis and the medical racism she faced. If you haven’t heard this episode yet, we very much encourage you to go back to Episode #288 and listen, this is o...2024-05-1726 min
TrialTalks Inc.Transforming Medicine: CRISPR's Impact on Genetic DiseasesSend us a text message with topics, questions, or comments!Join Naomi as she hosts Dr. Jeffrey Huang, a leading scientist from Mammoth Biosciences, in a captivating podcast episode focused on the groundbreaking CRISPR gene editing technology. Jeffrey provides an insightful overview of his journey from neuroscience research to spearheading innovations in gene therapy. He breaks down the complexities of CRISPR, discusses its transformative potential for treating genetic diseases, and addresses the ethical dimensions of this powerful technology. Whether you're deeply embedded in the scientific community or just curious about the future of medicine, this episode is...2024-05-131h 05
DNA Today: A Genetics Podcast#288 CRISPR Cured Victoria Gray’s Sickle Cell: Part 1It has happened. CRISPR has been successfully used to treat sickle cell, we’d even venture to use the term cure. And today we are talking with the first person in the world who was cured from a genetic condition using CRISPR, Victoria Gray!
Victoria is a patient advocate and international speaker from Mississippi. She is also a wife and mother of four children. Since being treated with CRISPR she has been featured in nearly every major publication including PBS, NPR, Forbes, New York Times, and more.
Victoria Gray, the first person...2024-05-1034 min
We Love ScienceEp 47: The CRISPR Cure for Sickle Cell DiseaseSend us a textIn this fourth installment of the CRISPR Chronicles, show hosts Fatu and Shekerah give a review of sickle cell anemia, the cause and symptoms of the disease, and discuss how the CRISPR gene therapy treatment works.Tune in to learn more about:The genetic basis of Sickle Cell DiseaseWhat Amazon delivery vans have in common with your Red Blood CellsThe effect of mutant hemoglobin on Red Blood CellsThe variety and severity of symptoms that SCD patients experienceThe disease burden of SCD throughout the worldThe clever strategy used to treat the d...2024-04-0834 min
TIL: ELI5Cracking the Code of CRISPR: A Journey Into Gene EditingWelcome to ELI5, where we untangle the spaghetti of science, one noodle at a time. Today, we're diving into a topic that sounds like it's straight out of a science fiction novel, but trust me, it's very real and incredibly fascinating: CRISPR and the world of gene editing. Imagine wielding a pair of molecular scissors, capable of snipping the DNA, the blueprint of life, and rewriting it to cure diseases, improve crop yield, and even resurrect extinct animals. Sounds like magic, doesn't it? Well, it’s not magic; it’s science, and it's called CRISPR.
CRISPR, short for Clustered Regu...2024-03-1303 min
Vida Saludable con DiabetesImpacto de la Edición Genética CRISPR en Tratamientos Futuros de la DiabetesEsta infografía destaca el revolucionario impacto de la edición genética CRISPR en los tratamientos futuros de la diabetes. Desde su definición y potencial, hasta los beneficios y consideraciones éticas, pasando por estudios de caso y avances recientes, cada sección ofrece una visión esperanzadora hacia una cura potencial. A través de símbolos intuitivos y gráficas, se presenta una ruta prometedora para superar los desafíos de esta condición crónica, marcando un camino hacia el futuro de la medicina personalizada.
Table of Contents
Introducción
Avances CRISPR, ¿Qué es CRISPR?
CRISPR y...2024-03-0504 min
Read & RepeatEP67 CRISPR & the Future of Gene EditingThe story of CRISPR reads like one straight out of a science fiction novel. It is filled with scientific breakthroughs, mad scientists, patent wars, and eventually, the ability to edit our own genes!
As a young kid, Jennifer Doudna was inspired by James Watson's The Double Helix. She wanted to learn more about this incredible field of DNA, but soon realized that thousands of other scientists had the same idea as her. So instead, she focused her energy on its less famous sibling, RNA. That proved to be a monumental decision.
2024-02-211h 06
We Love ScienceEp 41: Discovery, Development, and Cures - The CRISPR SagaSend us a textYou may think that the CRISPR-Cas genome engineering tool was developed from simple human ingenuity. And while its development certainly involved ingenuity, CRISPR was birthed in the wild. As a product of nature, it has an essential function in its native host; spoilers: its natural function involves defending its host from attacks. From the initial discovery in nature to its adoption as a gene therapy tool it took decades of twists and turns, ups, downs, and yes, ins and outs too. In this episode of We Love Science Podcast, Fatu and S...2024-01-1555 min
SALUD INTELIGENTE con Sento SegarraAvances en la Edición Genética CRISPR: Restaurando la VistaLa edición genética CRISPR ha llegado al campo de la oftalmología con una promesa emocionante: restaurar la vista en pacientes con daño en la retina. Este avance, discutido por el periodista especializado en ciencia, Sergio Parra, podría cambiar la vida de muchas personas que enfrentan problemas de visión y ceguera.
Edición CRISPR: https://www.nationalgeographic.com.es/ciencia/edicion-genetica-crispr-pacientes-ciegos-recuperar-vista_21174
La Importancia Médica
La retina, ese tejido esencial en el ojo humano que convierte la luz en señales para el cerebro, puede dañarse irreversiblemente. A diferencia de algunas especies, los humanos no pueden...2023-12-2008 min
We Love ScienceEp 38: The Secret Behind CRISPR Gene EditingSend us a textHumans have ~6 billion bases of DNA in each cell. But every gene has a specific and unique sequence that serves as a kind of genetic address. Before any gene can be edited, the editor must first find the gene's location within the genome. Luckily CRISPR-Cas has a built-in GPS component that makes finding a gene address easy, and switching out one genetic address for another is as easy as typing a street address into your Google Maps navigation app...well almost as easy. In this episode, show hosts Fatu and Shekerah...2023-12-0426 min
OncotargetThe Double-Edge Sword of CRISPR Application for In Vivo StudiesBUFFALO, NY- November 28, 2023 – A new #editorial paper was #published in Oncotarget's Volume 14 on November 27, 2023, entitled, “The double-edge sword of CRISPR application for in vivo studies.”
In this new paper, researcher Martin K. Thomsen from Aarhus University begins his editorial by discussing a hallmark paper that was published a decade ago by Platt et al. on the in vivo application of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to generate cancer in different organs of mice.
This hallmark paper outlines the advancement of delivering sgRNA’s to the target tissue to create loss or gain of function mutations without the need for time...2023-11-2802 min
Il FocusS01E04: CRISPR e le nuove frontiere del Genome Editing – Potenzialità e implicazioni eticheCos'è CRISPR
CRISPR è l'acronimo che sta per Clustered Regularly Interspaced Short Palindromic Repeats, una famiglia di elementi genetici batterici scoperti nel 1987 ma la cui funzione è stata compresa solo di recente. Si tratta di brevi sequenze di DNA che contengono le "istruzioni" per riconoscere e tagliare specifiche sequenze di DNA virale durante l'infezione, come meccanismo di difesa dei batteri.
La scoperta
CRISPR fu osservato per la prima volta nel 1987 da Yoshizumi Ishino e colleghi in E. coli. Tuttavia, la sua funzione rimase sconosciuta fino agli anni 2000, quando diversi gruppi di ricerca compresero il ruolo di...2023-10-3005 min
We Love ScienceEp 35: How CRISPR Gene Therapy is Bringing Hope to the WorldSend us a textEvery year, approximately 8 million children are born with a serious genetic disorder, and 3 million of them die before the age of 5. This disease burden is about to change. In this episode, we launch the CRISPR Chronicles series that will run throughout season 3. Since the pivotal paper by Doudna and Charpentier in 2012, CRISPR has taken the world by storm. Scientists have used this genome engineering tool in the lab to quickly and easily create mutants to study gene function in laboratory animals. But more importantly, the power of CRISPR gene editing as a biomedical...2023-10-2324 min
Climate BreakRERUN: Could We Use CRISPR to Fight Climate Change? with Professor Kris NiyogiWhat is CRISPR?DNA contains the fundamental information about an organism, and is used as an instruction manual to guide organism structure and function. Until CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats) technology was developed by Jennifer Doudna and Emmanuelle Charpentier, editing DNA sequences was very difficult. Here’s the short version of the CRISPR process. First, a CRISPR enzyme is guided by an RNA strand to a DNA strand researchers want to edit. The RNA strand guides the enzyme to a specific point, and the enzyme cuts the DNA molecule. This CRISPR process can be...2023-10-1701 min
バイオラジオ（BioRadio）【CRISPR-Cas9編】CRISPR-Cas9登場！！ クリスパーは違う研究の延長線上に生まれた！？【#3-4】ーー今回の内容ーー
第3シリーズは「CRISPR-Cas9編」
ついにCRISPR-Cas9が登場！！
クリスパーは違う研究の延長線上に生まれた！？
CRISPR-Cas9という不思議なカッコいい名前。
「CRISPR」「Cas」そして9の秘密が明らかに、、！
試行錯誤の研究の末。
自然に存在するすごい仕組みを大発見！！
ぜひお聞きください！
今回の一冊：クリスパー CRISPR 究極の遺伝子編集技術の発見
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パーソナリティ
・さかぽん（生物科教員）
・そうちゃん（音声コンテンツプロデューサー）2023-10-0425 min
EmpiristBilim-Kurgu Gerçek Oluyor: Gen Düzenleme ve CRISPR Cas9 Teknolojisi #bilim #gen #dna #crisprCRISPR teknolojisi, son yılların en heyecan verici gelişmelerinden biri olarak kabul edilir. Bu teknoloji, DNA'yı doğrudan düzenleme yeteneği sayesinde birçok hastalığın tedavisinde umut vadetmektedir.
CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats kelimelerinin kısaltmasıdır. Bu teknoloji, bakterilerin savunma mekanizmasını taklit ederek çalışır. Bakteriler, virüslere karşı savunmasını bu mekanizma sayesinde sağlar. CRISPR, DNA'daki belirli hedefleri tanıyabilen bir enzim olan Cas9 ile birlikte kullanılır. Bu sayede, Cas9 enzimi, belirlenen hedef DNA dizisini keser ve istenilen değişiklikler yapılabilmektedir.
CRISPR teknolojisi, genetik hastalıkların tedavisinde büyük...2023-05-2811 min
Xtalks Food Industry PodcastWHO Guidance Suggests Avoiding Sugar Substitutes for Weight Loss + CRISPR in the Food IndustryNew World Health Organization (WHO) guidance advises against the use of sugar substitutes for weight loss purposes. In this episode of the Xtalks Food Podcast, Sydney talks about the WHO’s review, which suggests that while a mild reduction in body weight may occur in the short term, it is not sustainable over time. The review also highlighted potential negative effects associated with long-term use of sugar substitutes, including a slightly increased risk of type 2 diabetes and cardiovascular diseases. The review incorporated 283 studies, including randomized controlled trials and observational studies. Both the Calorie Control Council, an international association representing th...2023-05-2630 min
Graeme Codrington's Future of WorkThrowForward Thursday 102: CRISPR - Editing DNA for a better futureThe 2020 Nobel Prize for Chemistry was awarded to Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier for their work on the gene editing technique known as CRISPR-Cas9. This gives us the ability to change the DNA of any living thing, from plants and animals to humans. The applications are enormous, from improving farming to curing diseases. A decade or so from now, CRISPR will no doubt be taught in High Schools, and be a basic building block of medicine and agriculture. It is going to change everything. There are ethical and moral c...2023-05-1807 min
State of the PodTime to Unwind: Decoding CRISPR and Genome EditingJoin our hosts as they dive deep into the history, development, application, shortcomings, and potential of the groundbreaking gene-editing technology, CRISPR. You’ll want to tune in as they explore how CRISPR is already changing the world around us, how it may one day transform the very fabric of our existence, including you, all the way down to your DNA. By the end of this episode you’ll be a gene-ius.
Produced and edited by Rma Polce, Alex Veldran, Marissa Brown-Johnson, and Ethan Tong
Art by Savannah Flores
Music from Karl Case...2023-05-0329 min
ALMAN IST LOST#0049: CRISPR#CRISPR #Gentechnik #JohnWick4 #OnePiece #Mindessteuer #Trauerweinerin #PandoraPapers
CRISPR ist die Chance unsterblich zu werden. Es ist die Chance Krankheiten wie Krebs, MS und HIV zu heilen. Alzheimer wird nur noch Geschichte sein. Die Chance und Risiken die CRISPR bietet sind immens. Wir fühlen der uns bevorstehenden Zukunft auf den Zahn.
Überblick
00:00 - 07:47 | 1 - Feedback-Runde: Globale Mindessteuer, Trauerweinerin
07:48 - 48:11 | 2 - Thema der Woche: CRISPR
49:12 - 01:06:40 | 3 - Top 3: One Piece MVPs
Sources
1 https://bit.ly/3YDsMZa Diese Trauerweinerin begleitet Beerdigungen | Weltspiegel
2 https://youtu...2023-04-111h 06
MindUnplugged Show with Dragos RaduS3 - E1 - Dr. Françoise Baylis - The Ethical Implications of CRISPR and BeyondWelcome to the latest episode of MindUnpluggedShow, where we delve into the fascinating world of CRISPR technology with the renowned bioethicist Dr. Françoise Baylis.About the Guest: Dr.Françoise Baylis is a philosopher and a leading voice in bioethics, pushing the boundaries of the field, challenging us to think deeply about the intersection of health, science, and biotechnology. Her innovative research focuses on human genome modification, assisted human reproduction, research involving women,and COVID-19. Dr.Baylis brings her ethical sensibility, theory, and common sense to a wide range of public issues.She is...2023-04-011h 01
CANCER BUZZPrecision Medicine: Stories from the CRISPR RevolutionKevin Davies, author of Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing, teases his keynote at the ACCC 49th Annual Meeting and Cancer Center Business Summit, where he will talk about the history of genome technology and its potential to change precision medicine. The first FDA approval for a CRISPR therapy is imminent. But can this game-changing technology deliver safe and affordable precision medicine for patients? Guest: Kevin Davies, PhD, Executive Editor of The CRISPR Journal and GEN Biotechnology and author of Editing Humanity: The CRISPR Revolution and the New Era of...2023-01-3106 minClimate BreakCould We Use CRISPR to Fight Climate Change? with Professor Kris NiyogiWhat is CRISPR?DNA contains the fundamental information about an organism, and is used as an instruction manual to guide organism structure and function. Until CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats) technology was developed by Jennifer Doudna and Emmanuelle Charpentier, editing DNA sequences was very difficult. Here’s the short version of the CRISPR process. First, a CRISPR enzyme is guided by an RNA strand to a DNA strand researchers want to edit. The RNA strand guides the enzyme to a specific point, and the enzyme cuts the DNA molecule. This CRISPR process can be...2023-01-1701 min
FutureBites with Dr. Bruce McCabeCRISPR and the Future of Food - with Rodolphe BarrangouWelcome to the first episode of FutureBites with Dr. Bruce McCabe. In this episode, Prof. Rodolphe Barrangou of North Carolina State University joins Bruce to talk about CRISPR and gene-editing and the future of food!CRISPR is short for CRISPR-Cas9. The CRISPR-Cas9 system and a family of related tools have brought faster, cheaper, more accurate, and more efficient methods to genome editing. They are unquestionably one of the top technologies changing the world right now.Professor Barrangou was involved early in the process of proving out the science of the role CRISPR played in nature. H...2022-11-0144 min
Mentors at Your BenchsideHow CRISPR-Cas13 Can Revolutionize Your RNA Research#31 — CRISPR can do more than edit DNA. Cas13, a CRISPR-associated protein that can bind and cut RNA, provides the power of CRISPR for studying RNA. Listen to the episode to discover how you can use Cas13 to knock-down, modify or track RNAs in mammalian cells. Plus learn how Cas13 can help you detect specific RNAs in patient samples in a matter of minutes.Visit the original article on CRISPR-Cas13 to see helpful diagrams and a table summarizing where to buy Cas13 plasmids. [1]Want to know more about how CRISPR can help your research? Visit our CR...2022-10-0408 min
Listen In - Bitesize Bio Webinar AudiosGuide to CRISPR/Cas9 Delivery How to Maximize EditingIn this webinar, you will learn how to maximize your genome editing efficiency using CRISPR/Cas9 and how to apply this technique in your research.The main points in the webinar will include:How to design guide RNAs using online tools specific to the genome and application of interest.Tips and practical advice to assist you in choosing and optimizing a CRISPR/Cas9 delivery system.How you can create precise mutations using homology-directed repair, including template design and cleavage siteAn Essential Guide to CRISPR/Cas9 Editing EfficiencyWhile CRISPR/Cas9...2022-09-011h 01
小農ラジオCRISPR changes the world. ゲノム編集が変える未来 #732022/7/1 TIME "How Jennifer Doudna's Life Has Changed Since Discovering CRISPR 10 Years Ago"
https://time.com/6192962/crispr-jennifer-doudna-10-year-anniversary/
CRISPR Cas 9
※遺伝子工学などを学んでいない二人が話しているので、間違いなどあればご指摘ください。
モヤモヤしてます/バークレー大学について/ハイレベル＆リベラル/遺伝子＝本の内容、DNA＝紙、染色体＝本、ゲノム＝全巻セット/GMOとゲノム編集の違い:GMOは別の生物の遺伝子挿入、ゲノム編集は1/30億の塩基の狙い撃ち/CRISPRは古細菌の免疫システムから/九州大学·石野教授が発見/High GABAトマト、マッチョ豚はノックアウト/オフターゲットのリスク/技術の悪用：Enhancement（進化）？/優生思想/Appearance（容姿）/ 中国での双子へのゲノム編集/ F1はいいのか？/「歯並びは親の責任だよ～」
「Genetic Engineering Will Change Everything Forever – CRISPR (遺伝子工学が全てを永遠に変える‐CRISPR)」
https://gigazine.net/news/20160812-genetic-engineering-change-everything/
農水省のゲノム編集Q&A
https://www.affrc.maff.go.jp/docs/anzenka/genom_editting.htm
松永和紀さんインタビューでとてもわかりやすくまとまってます。
奇妙な繰り返し配列クリスパーの謎【石野良純】
https://koken-publication.com/archives/1036
2022年CONSE FARM大雨被害応援商品はこちら！
https://conse.stores.jp
ハーブソルトがめっちゃ美味しいので是非試して欲しい、僕のおすすめはFor Tomato、野菜以外でも何にかけても美味しい！一振りで簡単レストラン！
小農ラジオではDiscordアプリで「小農ラジオ部」というコミュニティをやっています。土壌医のこと、有機栽培のことなど話してます。興味ある方は案内を送るのでDMください。
各種SNS、メールにてコメント、リクエストお待ちしてます。
https://linktr.ee/5danfarm
#土壌医 #農系ポッドキャスト
＜編集後記＞
今回の内容、ちょっと饒舌に話しすぎました。持論として「天然物は良いが、人工物はダメ」みたいなことを話していますが、極端な言い方をしてしまいました。言いたかったのは「不可逆的な技術」は使いたくないということです。ゲノム編集が世に放たれてしまえば、もう戻ることはできなくなってしまう（野生種と交配する）。
なお、農薬や化学肥料を否定するつもりはありませんので悪しからず。有機農業だけでは人類を養うことはできない所まで来てしまった今、必要な技術なのは間違いありません。しかしながら、これも生態系に影響を及ぼして「不可逆的」なことを起こしている可能性はあります。ここでもどちらの倫理が立つか？という事になりますが、僕も人類が飢えないようにする倫理を優先するという事です。
こんなふうにどちらの倫理を優先するのか、その軸がずれていく先はどうなるのか？踏みとどまるべきポイントは今なのではないか、という思いで話していますので、非科学的な戯言としてお聞きください。2022-09-011h 28
DNA Today: A Genetics Podcast#197 CRISPR Quality Control with Kiana AranWe have two special announcements!
Very soon we will be celebrating a decade of DNA Today! That’s right, we released our first episode on September 1st, 2012. It also coincides with our 200th episode. We want to mark these milestones with you on the show. So send in your favorite episode. You can write it, or better yet, record a voice memo sharing your favorite episode and why you enjoy listening to the show. After all, our podcast would not be possible without you loyal listeners. That’s why we want to celebrate together! Send in y...2022-08-1236 min
Steam ClubT2E18. EL CRISPR es el FUTURO!Fuentes:
CRISPR: así se editan los genes | Materia https://www.youtube.com/watch?v=ZoE-G7YPvZQ
El editor genético CRISPR explicado para principiantes https://www.agenciasinc.es/Reportajes/El-editor-genetico-CRISPR-explicado-para-principiantes
Jennifer Doudna, coinventora de CRISPR Cas9, pide precaución en su uso https://www.agenciasinc.es/Entrevistas/Tenemos-una-herramienta-que-se-puede-usar-para-controlar-la-evolucion-humana
La magia de CRISPR. https://bibvirtual.upch.edu.pe:2088/revistas/investigacion-y-ciencia/apolo-11-770/la-magia-de-crispr-17638
Riesgos de la edición genética. https://bibvirtual.upch.edu.pe:2088/revistas/investigacion-y-ciencia/las-singularidades-del-cerebro-adolescente-642/riesgos-de-la-edicin-gentica-13403
Qué es CRISPR y por qué es tan importante para nuestro futuro. https://futurizable.com/crispr/#:~:text=Entre%20las%20ven...2022-07-0911 min
High Output AIBizzare Signs of Recession and CRISPR Tomatoes | EP008Tom and Elliot discuss some of the more questionable signs that we might be in a recession and new work increasing Vitamin D in tomatoes using genetic modification with CRISPR.
TIMESTAMPS
00:00:00 Intro
00:02:55 This Week's Topics
00:06:54 Topic 1 Bizzare indicators of recession
00:12:58 Hemline Index
00:18:55 R-Word Index
00:22:08 Men's Underwear Index
00:31:42 Bonus Index List
00:40:05 Stripper Sentiment
00:41:23 Actual Recession Indicators
00:44:54 Topic 2 CRISPR Super Tomatoes
01:03:44 Wrapping Up
✍️SHOW NOTES
Part 1 - Stripper Things
...2022-06-011h 06
Stuyvesant NotationEpisode 8: CRISPR/Gene EditingJoin your host Neha Maskey (along with David Voynov and Keara O'Donnell) in our eighth episode as we discuss the development of CRISPR, its benefits, ethical concerns, and more! Check out SIGMA 19 here!Sources:https://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/https://www.labiotech.eu/interview/crispr-therapeutics-genome-editing/#:~:text=What%20are%20the%20advantages%20of,its%20relative%20simplicity%20and%20versatilityhttps://www.cancercenter.com/community/blog/2021/04/cancer-crisprhttps://news.berkeley.edu/2021/03/30/fda-approves-first-test-of-crispr-to-correct-genetic-defect-causing-sickle-cell-disease/https://www.science.org/content/article/crispr-injected-blood-treats-genetic-disease-first-timehttps://www.npr.org/sections...2022-05-0331 min
LuminexusThe CRISPR Revolution: The Past, Present and Future of CRISPR and What This Means For HumanityKevin Davies
The crazy thing about revolutions is that no one knows if you’re living through one until dozens of years later. Kevin Davies, internationally recognized author and journal editor, argues that we are currently living through a revolution. The CRISPR revolution. Quite similar to the scientific revolution through the 15th and 16th century, Kevin says that the CRISPR revolution will be as impactful as the scientific revolution.
We start this conversation where every good story should start: at the beginning. And we understand how CRISPR-Cas9 was discovered, and how the system works together to e...2022-04-181h 01
DijitalHayatTV"Gen Düzenleme Teknolojisi: CRISPR" | Bölüm37225.03.2022 | Dijital Hayat Bölüm372 - TRT Radyo1 | "Gen Düzenleme Teknolojisi: CRISPR"
Bilal Eren'in hazırlayıp, sunduğu Dijital Hayat programımızda bu hafta,
Üsküdar Üniversitesi Öğretim Üyesi Dr. Cihan Taştan ile;
- CRISPR Ne Demek?
- CRISPR Gen Düzenleme Teknolojisi Nasıl Çalışıyor?
- CRISPR Ne Zaman Keşfedildi, Tarihçesi?
- CRISPR Kim/Kimler Keşfetti?
- 2020 Nobel Kimya Ödülünü Alanlar, CRISPR Cas9 ile Ne Yaptılar?
- Gen Makası Nasıl Çalışıyor?
- DNA Düzenlemesi Neden İhtiyaç?
- CRISPR, İnsan Vücudunda Neleri Değiştirebilir?
- CRISPR Teknolojisi Fiziksel Hastalıklar...2022-03-2523 min
Dijital Hayat"Gen Düzenleme Teknolojisi: CRISPR" | Bölüm37225.03.2022 | Dijital Hayat Bölüm372 - TRT Radyo1 | "Gen Düzenleme Teknolojisi: CRISPR" Bilal Eren'in hazırlayıp, sunduğu Dijital Hayat programımızda bu hafta, Üsküdar Üniversitesi Öğretim Üyesi Dr. Cihan Taştan ile; - CRISPR Ne Demek? - CRISPR Gen Düzenleme Teknolojisi Nasıl Çalışıyor? - CRISPR Ne Zaman Keşfedildi, Tarihçesi? - CRISPR Kim/Kimler Keşfetti? - 2020 Nobel Kimya Ödülünü Alanlar, CRISPR Cas9 ile Ne Yaptılar? - Gen Makası Nasıl Çalışıyor? - DNA Düzenlemesi Neden İhtiyaç? - CRISPR, İnsan Vücudunda Neleri Değiştirebilir? - CRISPR Teknolojisi Fiziksel Hastalıklar...2022-03-2523 min
SarkaçCRISPR nedir, neden önemlidir? – Gözde KorkmazProgramda Crispr nedir? Gen düzenleme teknolojilerinin gelişimi, bakterilerin bağışıklık sistemi olarak CRISPR, CRISPR teknolojisinin uygulanması için nasıl şartlar gerekir? CRISPR’in keşfindeki bilimsel işbirliği, CRISPR’in uygulama alanları, etik kaygılar, CRISPR’ın aldığı Nobel Ödülü, gelecekte bizi nasıl araştırma soruları bekliyor? gibi birçok konuya değinildi.2022-03-1642 min
Working Capital ConversationsWalter Isaacson: The Science and Business of CRISPRThroughout nearly the entirety of human history, we have accepted a simple truth: A person’s genetic makeup is beyond one’s choice. Until now.
In 2020, the Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of CRISPR, a method for genome editing. CRISPR may change everything -- and land us in a world previously imaginable only in science fiction.
CRISPR can be wonderful and incredible. It may eliminate a child’s susceptibility to a genetic condition, such as cleft lip or cystic fibrosis or devastating disease. Imagine that. Howeve...2021-12-2926 min
CannabisTechCRISPR Cannabis Unlocking Genetic CodesWhile cloning is an ancient and effective practice, it is not standard across the agricultural industry. Instead, farmers use stable seeds or seeds that grow predictably and uniformly. Many farmers are keen on developing similar seeds for hemp and medical cannabis; however, the process may require using CRISPR-Cas9 technology.
CAN WE USE CRISPR FOR BETTER CANNABIS?
As CanBreed has already gotten approval to use CRISPR technology commercially for years, yes, CRISPR cannabis is here. In 2020, CanBreed reported they modified a cannabis gene to make the plant resistant to powdery mildew. This year the company obtained...2021-12-1006 min
Info Under The RadarS2E01 | CRISPR: Changing Course of Humanity with Kevin DaviesWelcome to season 2 of Info Under the Radar. New topics and new guests with your familiar hosts.
In the first episode of this new season, we are talking about one of the most revolutionary gene-editing technologies, CRISPR. We are talking about various facets of CRISPR with none other than Kevin Davies, who is the author of EDITING HUMANITY: The Crispr Revolution and the New Era of Genome Editing and many other books, links of all of which can be found below.
Timestamps
(06:15) - Why should a layperson care about CRISPR and how CRISPR came about?
(25:00) - Recap of how CRISPR...2021-12-061h 16
Lady Scientist PodcastDr. Kiana Aran, CRISPR-Chip Inventor, Cardea CSO, Professor and Biomedical Device PioneerMeet Dr. Kiana Aran – recent winner of Nature's Award for Inspiring Women in Science and the brain behind The CRISPR-Chip™, also known as the DNA Search Engine as it can search through whole genomes in minutes, with no cost of expensive lab reagents and no amplification errors. Kiana is also an Associate Professor at KGI where she runs her academic research lab www.aranlab.org. On this episode of Lady Scientist Podcast, Kiana uncovers her path to biomedical engineering, how the idea for The CRISPR-Chip™ came to her and what her personal invention process typically looks like, and the behind...2021-11-1840 min
TranslationNew CRISPR, New Function with Leo VoEpisode Summary:In a single decade, CRISPR has made a dramatic impact on literally every facet of biotechnology. This game-changing system is traditionally programmed to make cuts at very specific parts of the genome, altering the code to cure disease. But a new class of CRISPRs discovered by Leo’s colleagues don’t simply cut DNA -- they integrate entirely new genetic material at targeted locations. With it, Leo generates a new method to perform very specific and highly efficient genome engineering on bacteria and describes the multitude of ways it can generate strains that revolutize commodity mole...2021-09-0957 min
PubReadingPubReading [18] - Controlling and enhancing CRISPR systems - H. Shivram, B. Cress, G. Knott, J. DoudnaMany bacterial and archaeal organisms use CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) systems to defend themselves from mobile genetic elements. These CRISPR-Cas systems are classified into six types based on their composition and mechanism. CRISPR-Cas enzymes are widely used for genome editing and offer immense therapeutic opportunity to treat genetic diseases. To realize their full potential, it is important to control the timing, duration, efficiency and specificity of CRISPR-Cas enzyme activities. In this review we discuss the mechanisms of natural CRISPR-Cas regulatory biomolecules that enhance or inhibit CRISPR-Cas immunity by altering enzyme function. We also discuss the...2021-09-0248 min
Doomcast from Curated Doom058 - CRISPR - Tough Break Wonky chillbreak sonic soldier, CRISPR, marks his first appearance on the Doomcast with an original minimix of Phuture Triphop beats called Tough Break. Expect snatches of rap, batches of trap, and hatches of snap, crackle and pop. ----Every Sunday (-ish) we'll be releasing a new podcast with new and exclusive music you won't hear anywhere else. Live performances, alternative versions, DJ sets and more from Ghost of Wood, Elif Yalvaç, Maurice Dancer, Ian Fleming, Undergut, Team Satan, Cratered Skull, Kustom Electronix, PsyClone and many, many more! ----Search for "Doomcast" in your...2021-05-1500 min
GuidePost, A Podcast Series from The CRISPR JournalGuidePost Ep. 18: Kevin Davies, CRISPR ChroniclerIn this podcast, Mendelspod host Theral Timpson interviews Kevin Davies about his latest book, "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing".{Episode Sponsored by Mendelspod}2021-04-061h 02
Policy PunchlineGeorge Church: The Father of Human Genome Project and CRISPR Genome EngineeringGeorge Church is Robert Winthrop Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. He is known as the father of synthetic biology and the CRISPR-CAS9 gene editing technology, and he is widely recognized as one of the most important geneticists of our age. In 1984, he developed the first direct genomic sequencing method, which resulted in the first genome sequence. He helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He leads his own lab in Harvard and is also affiliated with the Broad Institute, the Wyss...2021-03-151h 21
MIND TalksEpisode 1: CRISPRYou may have heard of CRISPR before, but do you know what it is? Join us for a conversation with Dr. Derrick Rancourt, a Professor at the University of Calgary, who will break down CRISPR and tell you why you should care.
This episode will discuss:
1. Pre-CRISPR targeted mutagenesis
2. CRISPR as a disruptive technology
3. Applications of CRISPR
4. The CRISPR Patent Battle
5. The CRISPR Nobel Prize
6. CRISPR & COVID-19
7. CRISPR Employment Opportunities
Music: “Holiday” by Lukrembo.2021-01-0529 min
Chemistry in Everyday LifeThe Nobel Series Part III: The Gene Scissors, CRISPR/CAS9Welcome back to the last episode of this Nobel Prize series during which I discuss the technology for which the two research groups around Prof. emmanuelle Charpentier and Prof. Doudna received the joint Nobel Prize for chemistry. This episode will put all the pieces that we encountered over the course of the last two episodes together and finally will explain, how the so-called gene scissors, CRIPS/CAS9, work.I can now be reached on twitter under @ChemistryinEve1 , if you have feedback that you would like to share. Alternatively, you can send an email to chem.podcast@gmail...2020-11-2316 min
AlltagschemieDie Nobel Serie Teil III: Die Gen-Schere CRISPR/CAS9Willkommen zurück zur letzten Episode meiner Nobelpreis-Serie in der ich die Technologie bespreche, für den die Forschungsgruppen von Prof. Emmanuelle Charpentier und von Prof. Jennifer Doudna den Nobelpreis für Chemie erhalten haben. Diese Folge wird alles gelernte zusammenfügen und abschließen erklären, wie genau die sogenannte Gen-Schere CRISPR/CAS9 funktioniert.Willst du einen Kommentar zu dieser Episode oder zu diesem Podcast abgeben, dann gibt es zwei Möglichkeiten. Entweder schreibe mir auf Twitter unter @alltagschemie oder schicke mir einfach altmodisch eine email auf chem.podcast@gmail.com.Quellen· The origina...2020-11-2318 min
Parallax Views w/ J.G. MichaelEditing Humanity: The CRISPR Revolution and the New Era of Genome Editing w/ Kevin Davies
On this edition of Parallax Views, last month two female scientists, Jennifer Doudna and Emmanuele Charpentier, won the 2020 Nobel Prize in Chemistry for their revolutionary work on CRISPR-Cas9, a technology that opens the door gene editing in ways previously unimagined. The win has been, rightfully, seen as a pivotal moment for women in science, but what, beyond that, what is the broader story of CRISPR and gene editing? What are the broader implications of gene editing and what does it entail for bioethics (ie: could CRISPR be used for darker purposes such as eugenics or bioterrorism)? What...2020-11-111h 14
Sci GuysGene Editing with CRISPRThis week we chat about the genetic revolution and the ethics of editing human DNA...
You can WATCH the podcast over on our YouTube channel:
http://youtube.com/SciGuys
If you would like to support the podcast, please donate to our Patreon:
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References and Further Reading
https://www.britannica.com/science/DNA
https://w...2020-11-021h 21
The Insightful Thinkers PodcastCRISPR: The Future of Genetic EngineeringThe CRISPR-Cas9 system for genetic engineering has taken the world by storm. Along with creating bruise-resistant potatoes and apples that never brown, the biggest potential for this ground-breaking discovery lies in its potential to save lives. Discussed in this episode: The 2020 Nobel Prize in Chemistry for the CRISPR-Cas9 system, the history of CRISPR, CRISPR uses in genetically modified foods, uses for CRISPR in animal farming, CRISPR in human gene therapy, CRISPR uses in animal-to-human organ transplants, ethical concerns about using CRISPR, the logistical issues of widespread CRISPR implementation, and the future of genetic engineering.
Related re...2020-10-1331 min
Innovational Correctness#015: CRISPR – One of the Biggest Science Breakthroughs of the Decade /w Joram SchwartzmannCRISPR is considered one of the biggest and most important scientific breakthroughs of the past decade and will probably remain the biggest science story for the foreseeable future. CRISPR could revolutionize everything from medicine to agriculture - and it has worked on every organism it’s been tried on. And with COVID-19 at our doorsteps, this is a perfect time to get acquainted with the powerful new gene-editing technology called CRISPR.Topics covered:What CRISPR is - explained in simple terms,Why it’s considered to be one of the biggest scientific breakthroughs in the last...2020-10-121h 15
Lubię wiedzieć99. CRISPR nagrodzony NoblemMówię dziś o nagrodzonej w tym roku Noblem z dziedziny chemii metodzie CRISPR
Linki:
https://www.nobelprize.org/prizes/chemistry/2020/press-release/ - Nobel za CRISPR
https://pl.wikipedia.org/wiki/Metoda_CRISPR/Cas
https://biotechnologia.pl/biotechnologia/crispr-molekularne-nozyce-do-dna,16652 - duży artykuł o metodzie CRISPR
https://bit.ly/34KjXSW - o wyleczeniu anemii sierpowatej
https://bit.ly/33PomER - o leczeniu wrodzonej ślepoty za pomocą CRISPR
W tle gra: “Melting Sands” ELEPHNT2020-10-1108 min
16 Minutes News by a16zA Nobel for CRISPR! When, Who, How, What Now"It's CRISPR!" This week, the Nobel Prize in Chemistry was awarded to scientists Emmanuelle Charpentier and Jennifer Doudna (also an a16z co-founder, of Scribe Therapeutics), for the development of the CRISPR/Cas9 method for genome editing -- a technology that's "had a revolutionary impact on the life sciences, is contributing to new cancer therapies, and may make the dream of curing inherited diseases come true".While many describe this technology as "genetic scissors", one of the sharpest tools, is that analogy too limited for describing the true power and potential of CRISPR as a gene-editing platform...2020-10-1023 min
Cite Your SourcesEp 14 - Hacking Humans with CRISPRIn this weeks episode, Shelby & Charlie discuss an incredibly ethically and morally charged topic, CRISPR. CRISPR, clustered regularly interspaced short palindromic repeats, is a "technology" of sorts that allows researchers, scientists, or even the average person to alter and edit their genetic coding. Focusing mostly on the Netflix docu-series, Unnatural Selection, join us as we discuss some experiments that have been done with CRISPR, what's been successful, what fell short, some controversial actions taken by people, and even some conspiracy.
Sources:
https://www.addgene.org/crispr/history/#:~:text=CRISPR%20(Clustered%20Regularly%20Interspaced%20Short,was%20not%20elucidated%20until%202007.
https://www.yourgenome...2020-10-051h 21
GES Center Lectures, NC State UniversityRodolphe Barrangou - Catching up on the CRISPR crazeGenetic Engineering and Society Center
GES Colloquium - Tuesdays 12-1PM (via Zoom) NC State University | http://go.ncsu.edu/ges-colloquium
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Twitter - https://twitter.com/GESCenterNCSU
Catching up with the CRISPR craze: applications and implications of genome editing technologies
The advent of CRISPR-based technologies has revolutionized our ability to manipulate the genetic content of organisms across the tree of life, and democratized genome editing across the globe. Actually, genome editing technologies have been broadly deployed in...2020-09-241h 01
The Chicken Mind Nuggets's PodcastEp.22 CRISPR KremeChicken Mind Nuggets.
Hosted by Wifey
Chickenmindnuggets.com
chickenmindnuggets@gmail.com
@mindchicken
References for this episode
Brokowski, C., & Adli, M. (2019). CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool. Journal of Molecular Biology, 431(1), 88–101. https://doi.org/10.1016/j.jmb.2018.05.044
Gantz, V. M., & Akbari, O. S. (2018, May 22). Gene editing technologies and applications for insects. Retrieved October 22, 2019, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296244/
Larson, C., & Schaffer, A. (2014). Genome Editing. (cover story). MIT Technology Review, 117(3), 26. Retrieved from https://search.ebscohost.com...2020-09-2107 min
EpiSTEMCuriosities: CRISPR Series ConclusionThis is the curiosities episode for the CRISPR series as a whole. This episode jabs at questions and curiosities spawned by the CRISPR series. These ideas are split into two main groups: those relating to the biomimicry of CRISPR and those relating to the ethics of CRISPR. Can CRISPR be utilized in other fields as seen by those working with FPGAs? If so, is CRISPR really ethical or is it the impending doom of society to eugenics?
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· Anchor: The easiest way to make a podcast. https://anchor.fm/app
S...2020-09-0812 min
Innovation Unleashed PodcastCutting and Editing DNA with CRISPRIn everyday life, when we use the word Crisper we are likely referring to something that keeps produce fresh in the refrigerator…or something to do with the marketing of the beloved potato chip. But in the scientific and healthcare world, it is shorthand for "CRISPR-Cas9 and stands for "clusters of regularly interspaced short palindromic repeats." CRISPR is possibly the most impactful area of science to be invented since the discovery of DNA. We are going to learn more about CRISPR, but to do so we just need to remember that DNA is the molecule in all cells that cod...2020-06-2500 min
16 Minutes News by a16zCRISPR for Covid Testing and FDA EUAsAs calls for better, faster, cheaper, portable testing for COVID-19 disease are heard around the world -- given the important role of test-trace-isolate in re-opening the economy! -- the FDA recently issued an Emergency Use Authorization (EUA) for a CRISPR-based diagnostic.It's the first authorized use of CRISPR technology for an infectious disease test. So we discuss this topic in this week's episode of 16 Minutes -- our show where we cover the news headlines, tease apart what's hype/what's real from our vantage point in tech, and share where we are on the overall arc of various...2020-05-1720 min
The Bob & Kevin ShowEp. 063 - CRISPR and in-home biohacking kits and where this technology may take us, plus Diego the tortoise and his amazing sex driveIn this episode, Bob & Kevin talk all things CRISPR - basically the REGEX of DNA editing... and guess what? Apparently you can do it at home... soak in the transcript below (from our friends at https://otter.ai/) and feel free to ping us on social media with your thoughts on this episode or any of our others - Follow us on twitter at https://twitter.com/bobandkevinshow.
Kevin 0:00 So Bob, is this a safe place for discourse?
Bob 0:06 I hope so
Kevin 0:07 good. Because
Bob 0:09 I've been...2020-01-2100 min
IdioFactoCRISPR & NumerologyAs a nice follow-up to last week's GMO episode, Levi explains the process of Clustered Regularly Inter-spaced Short Palindromic Repeats (or CRISPR for short). Matt then runs us through numerology, where he assigns Levi a "name number" that dictates his personality... Or does it?
Show notes for CRISPR
CRISPR Timeline - https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline
Live Science article on CRISPR - https://www.livescience.com/58790-crispr-explained.html
Gif showing CRISPR CAS9 in action - https://www.livescience.com/60938-a-breathtaking-new-gif-shows-crispr-chewing-up-dna.html
...2019-12-1845 min
TapirCastGen Manipülasyonu ve CRISPR-CAS9 - Bölüm 2Ömer Faruk Başoğlu ve Halil Said Cankurtaran'ın yer aldığı bu bölümümüzde; CRISPR-CAS9 özelinde gen editleme yöntemleri ve büyük verinin sağlık alanında kullanımı üzerine konuşulmuştur.
00:10 Giriş
00:38 Gen editleme yöntemleri nelerdir? CRISPR’ı öne çıkaran özelliği nedir?
04:48 Bakteriler neden virüslerin DNA’sını saklamak zorunda kalıyor?
07:13 CAS9’ın işlevi
08:45 CRISPR-CAS9 süreci nasıl işliyor?
13:14 CRISPR gen editleme tekniğinin kullanım örneği
16:13 Klavuz RNA üretimi
18:16 CRISPR-CAS9...2019-11-2753 min
Pravidelná dávka98. Ako bioinžinieri upravujú gény: CRISPR a genetický kufrík s náradímGenetické inžinierstvo a génové úpravy patria medzi najvzrušujúcejšie oblasti moderného bioinžinierstva a vedy. Najpoužívanejším nástrojom využívaným na génové úpravy je CRISPR-Cas9. Čo to ale vlastne je? A ako to funguje?
O genetickom inžinierstve, o nástroji s názvom CRISPR-Cas9, jeho princípoch a fungovaní, o výhodách a nevýhodách sa budeme rozprávať v dnešnej Pravidelnej dávke.
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Referencie:
[1] Anzalone, A. V, Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., …...2019-11-0815 min16 Minutes News by a16zCRISPR: Policy, Platform, Trials (#11)This is the 11th episode of 16 Minutes, a weekly show where we quickly cover the top headlines of the week, the a16z Podcast way: why are these topics in the news; what’s real, what’s hype -- from our vantage point in tech.This week, we do a 20-ish minute deep-dive on CRISPR, to tease apart the FUD from the facts given a bunch of recent news (not research!) around the gene-editing platform. The news implications range from policy to practice:At the end of July, one of the first laws to directly regulate CRIS...2019-10-0823 min
Meet the MicrobiologistCRISPR, anti-CRISPR, and anti-anti-CRISPR systems with Joe Bondy-DenomyCRISPR is a genome-editing tool, but what is its role in microbial biology and evolution? Joe Bondy-Denomy discusses his discovery of the first anti-CRISPR protein and the many unanswered questions surrounding CRISPR biology. Julie’s Biggest Takeaways CRISPR is a bacterial immune system that identifies and destroys specific nucleotide sequences. These sequences are most commonly associated with foreign DNA from bacteriophage or plasmids. Bacterial acquisition of new CRISPR spacer sequences is fairly inefficient, and often a bacterium dies before acquiring and fending off a new phage infection. Only about 1 in a million cells em...2019-05-0247 min
GuidePost, A Podcast Series from The CRISPR JournalEp. 9: Emmanuelle Charpentier, CRISPR-Cas pioneerIn a French bistro in New York City, Emmanuelle Charpentier (Founding Director, Max Planck Unit for the Science of Pathogens, Berlin) discusses with Kevin Davies her nomadic career, the high points in her CRISPR journey, and previews her future plans.2019-02-0550 min
GuidePost, A Podcast Series from The CRISPR JournalEp. 4: Jacob Sherkow, CRISPR patents explainedIn episode #4 of GuidePost, Jacob Sherkow (New York Law School) – one of the leading academic authorities on biotech patent law – explains the twists and turns of the ongoing CRISPR patent dispute.2019-02-0134 min
Chaos Computer Club - archive feed (high quality)Genom-Editierung mit CRISPR/Cas (35c3)CRISPR/Cas hat die Genforschung revolutioniert und könnte bald in großem Stil gentechnisch eingesetzt werden. Aber was ist CRISPR und wie funktioniert es? Kurz gesagt: Teile des adaptiven Immunsystems von Bakterien werden genutzt, um Gene zu verändern. Und das funktioniert präziser als mit jedem anderen Werkzeug zuvor und offenbar in allen Tier- und Pflanzenarten. Damit ist CRISPR anders als die herkömmlichen Methoden der Gentechnik. Es ist einfach anzuwenden, preiswert, schnell, extrem vielseitig und damit in jedem Biologielabor erhältlich. Bio-Hacker haben sogar begonnen, CRISPR zu Hause zu nutzen. CRISPR wird bereits eingesetzt, um mehr über Genfunk...2018-12-2744 min
Chaos Computer Club - 35C3: Refreshing Memories (mp3)Genom-Editierung mit CRISPR/Cas (35c3)CRISPR/Cas hat die Genforschung revolutioniert und könnte bald in großem Stil gentechnisch eingesetzt werden. Aber was ist CRISPR und wie funktioniert es? Kurz gesagt: Teile des adaptiven Immunsystems von Bakterien werden genutzt, um Gene zu verändern. Und das funktioniert präziser als mit jedem anderen Werkzeug zuvor und offenbar in allen Tier- und Pflanzenarten. Damit ist CRISPR anders als die herkömmlichen Methoden der Gentechnik. Es ist einfach anzuwenden, preiswert, schnell, extrem vielseitig und damit in jedem Biologielabor erhältlich. Bio-Hacker haben sogar begonnen, CRISPR zu Hause zu nutzen. CRISPR wird bereits eingesetzt, um mehr über Genfunk...2018-12-2744 min
Sciencentric#2 Everything We Know about the CRISPR BabiesWe explore the latest news out of China that a scientist has created genetically-modified babies using the CRISPR-Cas9 gene editing system.
Support us on Patreon: https://bit.ly/2GjxdoL
Check our list of recommended science books: https://bit.ly/2zOIiYU
Links:
The He Lab YouTube Channel:
https://www.youtube.com/playlist?list=PL0MrOF3n_8ZrklRxAm4zoA_zBiG7mvMU4
Why Are Scientists So Upset About the First Crispr Babies? https://www.nytimes.com/2018/12/05/health/crispr-gene-editing-embryos.html
First CRISPR Babies: 6 Questions That Remain https://www.scientificamerican.com/article/first-crispr-babies-6-questions-that-remain/
What are genome editing and CRISPR-Cas9? https://ghr.nlm.nih.gov...2018-12-0837 min
omega tau - English onlyGene Editing with CRISPR/Cas
Guest: Sam Sternberg Host: Markus Voelter Shownoter: Thomas Machowinski
CRISPR is a family of DNA sequences in bacteria and archaea that are a part of these organisms’ cellular defense system. A recent discovery showed how this mechanism can be used to edit genes much more easily than legacy methods. In this episode I chat with Sam Sternberg about the naturally occuring CRISPR systems, how they work, and how CRISPR together with its associated enzymes can be used to cut, and subsequently, edit, DNA. We conclude the episode with an outlook on the pote...2018-09-141h 31
Innovation OvergroundInnovation Overground: The CRISPR episodeEveryone has a take on CRISPR. Join the Overground crew as they provide a brief overview of CRISPR and its current limits on curing diseases and creating rampaging supervillains. The trio then discuss how Easi-CRISPR, a technology jointly invented at UNMC and the University of Tokai, neatly fills in the current limits of genome editing for both applications.
Featured Technologies: Easi-CRISPR (https://www.unemed.com/product/crispr-cas9-editing-tool & https://www.unemed.com/product/easi-crispr-therapeutic)
Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge)
Sponsor: UNeMed (https://www.unemed.com); @UNeMed
Music: Countdown to Myocardial Infarction, by Peter Gresser. Used with...2018-08-0622 min
Innovation OvergroundInnovation Overground: The CRISPR episodeEveryone has a take on CRISPR. Join the Overground crew as they provide a brief overview of CRISPR and its current limits on curing diseases and creating rampaging supervillains. The trio then discuss how Easi-CRISPR, a technology jointly invented at UNMC and the University of Tokai, neatly fills in the current limits of genome editing for both applications. Featured Technologies: Easi-CRISPR (https://www.unemed.com/product/crispr-cas9-editing-tool & https://www.unemed.com/product/easi-crispr-therapeutic)Hosts: Charlie Litton (@charlielitton); Tyler Scherr (@dare2scherr); Joe Runge (@HJRunge) Sponsor: UNeMed (https://www.unemed.com); @UNeMed 2018-08-0622 min
GuidePost, A Podcast Series from The CRISPR JournalEp. 3: Rodolphe Barrangou, the CRISPR crazeThe CRISPR Journal Executive Editor Kevin Davis interviews Editor-In-Chief Rodolphe Barrangou. This episode of GUIDEpost is brought to you by Synthego, who's vision is to turn biology into an information science with the ultimate goal of dramatically extending the healthy human lifespan by providing genome engineering solutions. Learn more at www.synthego.com.2018-02-0336 min
Business and PhilosophyCRISPR with Geoff Ralston
CRISPR is a technique for altering the human genome. It might be the most powerful tool for biological modification that we have ever discovered. In this episode, we explore CRISPR: how it works, why it exists in the natural world, and the implications for being able to modify DNA so easily.
Geoff Ralston is a partner at Y-Combinator. He wrote an article entitled Hacking DNA: The Story of CRISPR, Ken Thompson, and the Gene Drive. Since Geoff is not a biologist, he is the perfect person to explain CRISPR to an audience of non-biologists.
2017-05-0559 min
Greatest Hits Archives - Software Engineering DailyCRISPR with Geoff Ralston
CRISPR is a technique for altering the human genome. It might be the most powerful tool for biological modification that we have ever discovered. In this episode, we explore CRISPR: how it works, why it exists in the natural world, and the implications for being able to modify DNA so easily.
Geoff Ralston is a partner at Y-Combinator. He wrote an article entitled Hacking DNA: The Story of CRISPR, Ken Thompson, and the Gene Drive. Since Geoff is not a biologist, he is the perfect person to explain CRISPR to an audience of non-biologists.
2017-05-0559 min
Mentors at Your BenchsideGuide to CRISPR/Cas9 Delivery: How to Maximize Your Editing In this webinar, you will learn how to maximize your genome editing efficiency using CRISPR/Cas9 and how to apply this technique in your research.
The main points in the webinar will include:
- How to design guide RNAs using online tools specific to the genome and application of interest.
- Tips and practical advice to assist you in choosing and optimizing a CRISPR/Cas9 delivery system.
- How you can create precise mutations using homology-directed repair, including template design and cleavage site
While CRISPR/Cas9 editing is utilized in a wide variety of cell types, editing efficiency continues to...2017-04-1900 min
Listen to Most Popular Audiobooks in Radio & TV, Science & TechnologyUpdate: CRISPR Audiobook by Jad Abumrad, Robert KrulwichListen to this audiobook free with a 30-day trial. Go tohttp://hotaudiobook.com/freeTitle: Update: CRISPR
Author: Jad Abumrad, Robert Krulwich
Format: Original Recording
Length: 49 mins
Language: English
Release date: 02-27-17
Publisher: Radiolab, WNYC Studios
Genres: Radio & TV, Science & Technology
Publisher's Summary:
It's been almost two years since we learned about CRISPR, a ninja-assassin-meets-DNA-editing-tool that has been billed as one of the most powerful, and potentially controversial, technologies ever discovered by scientists. In this episode, we catch up on what's been happening (it's a lot), and learn about CRISPR's potential to not only change human evolution, but every organism...2017-02-2749 min