Shows
Glaucoma, Vision & Longevity: Supplements & ScienceIGF-1, mTOR Signaling, and Neurodegeneration Across Eye and BrainThis audio article is from VisualFieldTest.com.Read the full article here: https://visualfieldtest.com/en/igf-1-mtor-signaling-and-neurodegeneration-across-eye-and-brainTest your visual field online: https://visualfieldtest.comSupport the show so new episodes keep coming: https://www.buzzsprout.com/2563091/supportExcerpt:Introduction Glaucoma is now recognized not just as an eye pressure problem but as a neurodegenerative disease of the optic nerve. Retinal ganglion cells (RGCs) – the neurons that send visual signals from eye to brain – degenerate in glaucoma, much like neurons die in Alzheimer’s or Parkinson’s disease () (). Research...
2026-01-0925 min
Medizin neu gedachtFolge 2 Jeder will Anti Aging, aber niemand kennt mTOR
In dieser Episode von Medizin neu gedacht erfährst du, warum unsere Mitochondrien – die Kraftwerke der Zellen – und der Stadtplaner mTOR entscheidend dafür sind, wie wir altern.
Wir sprechen darüber:
warum gesunde Mitochondrien die Basis für Energie und Zellgesundheit sind,
wie freie Radikale wie kleine Funken wirken und warum oxidativer Stress ein „Rostprozess“ in der Zelle ist,
weshalb mTOR der Schalter zwischen Wachstum und Reparatur ist,
was passiert, wenn Kraftwerke und Stadtplaner nicht im Einklang arbeiten (→ Hallmarks of Aging),
wie Bewegung und Essenspausen der Zellstadt helfen, sauber und leistungsfähig zu bleiben,
warum Proteine, Polyphenole, Schlaf & Stress so wichtig sind...
2026-01-0417 min
Modern Medicine mit Alessandro Falcone#62 - Protein, mTOR and Caloric Restriction: Understanding the Biology of Aging | Prof. Matt KaeberleinBONUS Episode:Das ist eine besondere Modern Medicine Episode. Es ist meine erste Folge auf Englisch und damit ein Gespräch, das dir direkte Einblicke in die internationale Longevity Forschung gibt.Ich hatte die Ehre mit Prof. Matt Kaeberlein zu sprechen, ein US amerikanischer Biologe und einer der prägenden Forscher im Bereich der molekularen Alterungsmechanismen.Wir sprechen darüber, wie sinnvoll gängige Tests zur Bestimmung des biologischen Alters wirklich sind, warum mTOR als zentraler Stoffwechsel Schalter Alterungsprozesse mitsteuert und wie Ernährung, Kalorienrestriktion und Proteinzufuhr diese...
2025-12-301h 31
MD Longevity Lab: Playing the Long Game19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt KaeberleinIn this episode of MD Longevity Lab: Playing the Long Game, Drs. Nisha and Vikas Patel sit down with world-leading aging researcher Dr. Matt Kaeberlein to cut through the noise in longevity medicine.We discuss why most biological aging clocks fall short, what mTOR actually does, how rapamycin works (and why it’s widely misunderstood), what truly moves the needle for healthspan, and where AI and preventive medicine are headed.This is an evidence-based conversation focused on clarity, nuance, and long-term thinking—without the hype.Topics Covered • Why biological aging clocks are unreliable at the individual level • mTOR explained and its...
2025-12-251h 15
MD Longevity Lab: Playing the Long Game19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt KaeberleinIn this episode of MD Longevity Lab: Playing the Long Game, Drs. Nisha and Vikas Patel sit down with world-leading aging researcher Dr. Matt Kaeberlein to cut through the noise in longevity medicine.
We discuss why most biological aging clocks fall short, what mTOR actually does, how rapamycin works (and why it’s widely misunderstood), what truly moves the needle for healthspan, and where AI and preventive medicine are headed.
This is an evidence-based conversation focused on clarity, nuance, and long-term thinking—without the hype.
Topics Covered
Why biological aging clocks are unreliable at t...
2025-12-251h 15
Glaucoma, Vision & Longevity: Supplements & ScienceGene Therapy for Optic Nerve Regeneration: Modulating PTEN/mTOR, KLFs, and Sox11This audio article is from VisualFieldTest.com.Read the full article here: https://visualfieldtest.com/en/gene-therapy-for-optic-nerve-regeneration-modulating-pten-mtor-klfs-and-sox11Test your visual field online: https://visualfieldtest.comExcerpt:IntroductionVision loss from optic nerve injury or glaucoma happens because retinal ganglion cells (RGCs) fail to regrow their axons. In adult mammals, the intrinsic growth program of RGCs is normally shut off, so damaged nerves do not heal on their own (). Recent mouse studies show that gene therapy can reactivate these growth pathways. For example, deleting the PTEN gene (a brake on cell growth) in...
2025-12-1414 min
Optimization Academy with Dr. Greg Jones77. Protein, Leucine & Longevity: Dr. Layman on Building Muscle, mTOR, and Aging BetterIn this episode, Dr. Jones is joined by Dr. Donald Layman, one of the world’s top experts in protein metabolism. They discuss what happens to our muscles as we age, why leucine is a key amino acid for building and repairing muscle, and the amount of protein needed to stay strong and healthy.Dr. Layman also explains the differences between lifespan, longevity, and health span — and how muscle helps us stay active and independent as we age. You’ll hear why muscle supports recovery from illness or injury, and why it’s essential to protect it long bef...
2025-12-091h 06
Limitless: Biohacking Brainpower, Health, Personal Growth & BeyondMetformin: This AMPK/mTOR Longevity Hack Stinks! What to take instead to hack insulin... This pharmaceutical is an insulin hack and the most studied diabetes drug, yet it remains highly controversial as an anti-aging and longevity tool for biohackers.I have met my match as a researcher, Metformin. I'm not sure if Metformin is a game-changing anti-aging drug or a really problematic pharmaceutical. But you'll learn here why it's something that Biohackers seeking performance enhancement can pass on...5:25 Scientific Research6:19 History7:38 A Metabolism Hack8:58 An Insulin Hack10:35 An AMPK Hack11:30 An mTOR Hack14:22 Vs Type 2...
2025-10-0640 min
ECHTgesund Daily – Wissen, das dich weiterbringtmTOR-Signalweg – wie Protein Muskelwachstum wirklich steuertDer mTOR-Signalweg gilt als einer der wichtigsten Schalter für Muskelaufbau – doch was steckt dahinter? In dieser Folge erfährst du:Grundlagen von mTOR – was der Signalweg ist und warum er zentral für Wachstum und Regeneration ist.Die Rolle von Protein – wie Aminosäuren, besonders Leucin, den mTOR-Signalweg aktivieren.Aktuelle Forschung – welche Studien zeigen, wie Training und Ernährung zusammenwirken.Praxis-Tipps – was das für deine Ernährung und dein Training konkret bedeutet.👉 Jeden Tag eine neue Folge – leicht verständlich, wissenschaft...
2025-10-0208 min
The mTOR You KnowPharmacogenomics in Practice: Tacrolimus and BeyondIn this episode of The mTOR You Know, we dive into the evolving role of pharmacogenomics in solid organ transplantation with a focus on tacrolimus andCYP3A5. Our expert panel—Jennifer Trofe, Amy Pasternak, and Shirley Tsunoda—share insights on clinical trial data, guideline perspectives, and real-world application of genotype-guided dosing. We explore the benefits and limitations of CYP3A5 testing, touch on other transplant medications with pharmacogenomic considerations, and discuss barriers such as cost, access, and implementation. The conversation also highlights national survey findings,cost-effectiveness analyses, and strategies for integrating pharmacogenomics into clinical practice.Li...
2025-09-0952 min
Kiwicast - O Podcast da KiwifyDe Personal Trainer a Empreendedor de 8 Mi com a Técnica MTOR | Mauricio Medeiros - Kiwicast #471O Mauricio Medeiros é criador da técnica de execução MTOR e referência em musculação e saúde da mulher. No episódio de hoje do Kiwicast, ele conta como faturou R$ 8 milhões de reais ajudando a transformar a vida de profissionais de educação física com seu conhecimento.O que você vai aprender:- Como manter uma comunidade engajada- Estratégias que ele usou para se destacar no mercado- A criação do método MTOR- Diferenças entre treino para mulheres e homens- Estratégias de vendas do produto dele- Como as aulas gratuitas f...
2025-07-071h 08
RadOnc Smart ReviewRadBio E38: Oncogenic Pathways: RAS/MAPK, PI3K/AKT/mTOR, and HIF-1αWelcome back to Rad Onc Smart Review! This is Episode 38: Oncogenic Pathways: RAS/MAPK, PI3K/AKT/mTOR, and HIF-1α. In our previous discussions, we've explored how cells sense and repair DNA damage, and how they make life-or-death decisions through apoptosis. Today, we're shifting our focus to some of the major signaling pathways that, when dysregulated, drive cancer development and can profoundly influence a tumor's response to radiation therapy. We'll dissect the RAS/RAF/MEK/ERK pathway, a critical engine for cell proliferation; the PI3K/AKT/mTOR pathway, a master regulator of cell growth, survival, and metabolism; and the H...
2025-05-3028 min
Nutrition Facts with Dr. GregerSuppressing mTORmTOR’s a master determinant of lifespan and the engine of aging.
This episode features audio from:
The Enzyme mTOR as an Engine of Aging
Inhibiting mTOR with Rapamycin for Extending Lifespan and Healthspan
Is Rapamycin a Universal Anti-Aging Drug?
Visit the video pages for all sources and doctor’s notes related to this podcast.
2025-05-2913 min
Longevity Roadmap137: Dr. Joan Mannick - Targeting mTOR to Improve Immune Function and HealthspanWhat if targeting a single cellular pathway could slow aging and boost immunity? Dr. Joan Mannick, a leading voice in aging science, reveals how mTOR inhibitors may be the future of longevity therapeutics. From her early inspiration to groundbreaking clinical trials, Dr. Mannick explores the role of mTOR in aging, immune response, and antiviral immunity. Learn how selective mTOR inhibition could extend healthspan without compromising muscle mass, improve vaccine response in older adults, and unlock new possibilities in clinical longevity. Learn more about Dr. Joan Mannick: https://www.linkedin.com/in/joan-mannick-8089a614/
2025-05-2642 min
Mind & MatterLinoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229Send us a textEpisode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth; role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats; differences between breast cancer subtypes; broader implications of dietary balance for health.About the guest: John Blenis, PhD is a Professor of Pharmacology at the Meyer Cancer Center at Weill Cornell Medicine. Nikos Koundouros, PhD is a postdoctoral fellow in Blenis’ lab.
2025-05-151h 47
Mind & MatterLinoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229This is a free preview of a paid episode. To hear more, visit mindandmatter.substack.comWide release date: May 15, 2025Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth. They explore the role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats, the differences between breast cancer subtypes, and the broader implications of dietary balance for health, emphasizing the need for personalized nutrition strategies.About the guest: John Bl...
2025-05-061h 47The mTOR You KnowCutting Edge: Maximizing the Gift of Life with Surgical TechnologyTransplant surgeons Dr. Manish Gupta and Dr. Garrett Roll chat with hosts Aileen Chi and Kimberly Leale on this exciting multidisciplinary episode of The mTOR You Know. Join us as we learn amazing insight about new surgical technology and its impacts on immunosuppression, outcomes, and the global transplant ecosystem. You're going to want popcorn for this one!
2025-04-2252 min
Modern Thyroid and Wellness27: The Longevity Switch in Your Cells – Unlocking mTOR for a Healthier Life with Dr. Dudley LammingIn this podcast episode, the host introduces the concept of mTOR (mechanistic target of rapamycin) and its significant role in aging, healthspan, and longevity. The guest, Dr. Dudley Lamming, an expert in aging and metabolism, explains mTOR's function in nutrient sensing and cellular processes. They discuss how mTOR activation promotes growth but can accelerate aging and disease if overly active. Dr. Lamming shares insights on how fasting, caloric restriction, and balanced protein intake can modulate mTOR activity to enhance health and longevity. Practical lifestyle changes, such as intermittent fasting and maintaining metabolic health, are recommended for optimal mTOR regulation.
2025-03-2436 min
The Becoming Young PodcastAubrey de Grey: Can We Reverse Aging? Rapamycin, mTOR & Longevity ScienceIn this episode of Becoming Young, Josh and Janae sit down with legendary longevity researcher Aubrey de Grey to explore the future of aging science and what it means for human lifespan. They dive deep into the latest breakthroughs in mTOR, rapamycin, senescence, and cellular rejuvenation, uncovering how cutting-edge research is redefining what’s possible for human healthspan.Things we discussed...The history of aging research and why scientists once believed aging was inevitableAubrey de Grey’s new mouse studies and what they reveal about reversing agingRapamycin, mTOR, and autophagy—how this p...
2025-03-1156 min
Journal of NeurophysiologyJNP Podcasts: Unlocking Insulin's Mechanism: Activation of Parasympathetic Hepatic Neurons via mTOR SignalingIn this episode, coauthor Karoline Martins dos Santos discusses the recently published research, "Insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mTOR signaling." The study investigates the complex role of insulin in regulating hepatic glucose production, focusing on how insulin influences specific brain regions. While it's known that insulin reduces liver glucose production, the precise mechanisms and brain areas involved have remained unclear. Dr. Martins dos Santos explains how insulin activates parasympathetic hepatic-related neurons in the paraventricular nucleus (PVNhepatic) and how this process relies on mTOR signaling.
Insulin activates parasympathetic hepatic-related ne...
2025-03-0708 min
Carnivore Coaches Corner094: Monocarboxylate Transporters, mTOR, & The 2nd Annual Ultimate Men’s Health RetreatTIME STAMPS:00:43 Inspiration behind the 2nd annual ULTIMATE MEN’S HEALTH RETREAT *details & signup info* https?//umhr.co.uk03:14 WIM HOFF, DORIAN YATES, RICHARD SMITH & other legendary keynote speakers!09:18 The A.L.P.H.A. (anabolic leverage protein and hormone activation) diet; summary of Al Reeve’s cyclical keto diet for lean bulking!13:35 How C8 Medium Chain Triglycerides stimulates endogenous ketone production and why ketogenic performance is increased as a result.14:31 The difference between C8, C10, & C12 - everything fat-adapted athletes need to know about fatty acid metabolism to opti...
2025-02-221h 21
Architect of ResilienceCM#6: Cancer, Metformin, and the mTOR Pathway: Separating Fact from Fiction in Insulin Mimetic TherapyChris Duffin sits down with expert guest Anthony Castor to delve deep into the fascinating world of insulin mimetics, glucose metabolism, and their implications for overall health and aging. The conversation kicks off with an examination of metformin's widespread use in diabetes management and its controversial potential benefits in cancer prevention, as highlighted in a recent study that casts doubt on its anti-cancer efficacy. Anthony and Chris explore the intricacies of balancing key cellular pathways—AMPK and mTOR—and their roles in muscle metabolism and aging. They discuss how the AMPK pathway acts as a guardian of ener...
2025-01-1723 min
Feel Freaking Amazing™Longevity and mTOR: What the Science Says, with Dr. Robert LufkinThe molecule mTOR could be the key to living a vibrant and long life. Dive into an eye-opening conversation about mTOR with an expert who has reversed chronic disease and dedicated his life to helping others do the same. This signaling molecule could be the game-changer you've been looking for regarding healthy aging and longevity. In this episode, Dr. Robert Lufkin, a physician and medical school professor at UCLA and USC, dives deep into the role of mTOR in aging, chronic diseases, and longevity. He sheds light on the significance of mTOR as a metabolic switch that...
2024-12-1622 min
LifeX161. mTOR e Longevità: Anabolismo, Rapamicina, Digiuno Intermittente e Anti-Aging – con David SabatiniSponsor: London Nootropics: offrici un caffé nootropico, potenzia il cervello e comprendi meglio i nostri podcast! Per supportarci usa il codice "LIFEX" al momento dell'acquisto. Un extra perla per i nerd, ossia una puntata in inglese con un ospite d'eccezione: David Sabatini, Senior Group Leader, Institute of Orcanic Chemistry and Biochemistry (IOCB), Praga, Repubblica Ceca, scopritore di mTOR e massimo esperto mondiale sulla rapamicina e le sue interazioni per la longevità. Siamo sempre stati abituati ad associare mTOR all'anabolismo muscolare: c'è qualcosa in più che dobbiamo sapere?
2024-09-1846 min
Dr. Jockers Functional NutritionThe Truth About mTOR, Autophagy and LongevityIn this episode, explore the essential balance between mTOR and autophagy for optimal longevity. Learn how these cellular processes affect health as you age and the consequences of imbalances. Discover key lifestyle strategies that influence longevity, such as the benefits of intermittent fasting, nutritional ketosis, and polyphenols. Find out how these methods naturally inhibit mTOR and boost autophagy for a healthier life. Dive into the dual role of exercise in regulating mTOR and autophagy. Understand how exercise not only facilitates muscle growth but also promotes cellular cleanup, supporting overall muscular and...
2024-09-0518 min
The Lab ReportWhat the heck is mTOR?There are a lot of terms bantered about in the biohacker and longevity space. With that, you’ve likely heard of mTOR – mechanistic (mammalian) target of rapamycin. But what exactly is it? mTOR is a key regulator in your body’s metabolic and growth processes. It integrates various signals, including nutrients and growth factors, to control processes like protein synthesis, autophagy, and lipid metabolism. Because it regulates growth, dysregulation of mTOR has been implicated in various diseases, including cancer. In today’s episode, we simplify the science behind mTOR – mechanistic target of rapamycin. This crucial enzyme may be the key...
2024-08-0624 min
Decoding Healthcare ResearchIs mTOR the Key to Anti-Aging and Longevity?In this episode, we have Dr. Dudley Lamming, PhD, Associate Professor and Researcher at the Department of Medicine, Endocrinology at the University of Wisconsin-Madison. We will talk about aging and specifically about a molecule that has been gaining interest in the scientific field: mTOR. We’ll discuss its importance, how it is regulated, and much more. Additionally, we will explore the effects of Rapamycin and its potential pharmacological applications. Join us for an insightful discussion! Dr. Lamming’s research focuses on understanding how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
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2024-08-0336 min
Optimal Protein Podcast with Vanessa SpinaAutophagy Scientist Dr. Kurt Escobar: How to Upregulate Autophagy in Humans, Dispelling the Hype about Fasting, Mtor & More!The BRAND NEW 2nd Generation Tone Devices have launched!! Order HERE Hi friends! This episode is featuring autophagy scientist Dr. Kurt Escobar on how to upregulate autophagy in humans, dispelling the hype about fasting, Mtor & more! See full bio below. *TIMESTAMPS BELOW Studies mentioned in this episode: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Does Exercise Regulate Autophagy in Humans? ASystematic Review and Meta-Analysis Timeline: Get 10% off Mitopure, clinically proven to boost mitophagy. Go to timeline.com/vanessa. Sign up for...
2024-07-291h 37
The Health Fundamentals podcastEpisode #52: The Science of mTOR: How It Impacts Aging and DiseaseEpisode Summary: In this episode of the Health Fundamentals podcast, Dr. Chad Woolner delves into the intriguing realm of mTOR, highlighting its significant role in human health and longevity. Initially narrating the discovery of mTOR in the 1990s, how it started with a discovery that derived from soil samples on Easter Island, Dr. Woolner highlights the journey from Rapamycin's antifungal uses to a better understanding of its central role in chronic health conditions. The conversation advances into the multifaceted ways lifestyle choices impact mTOR activity within our cells. Woolner dives into actionable steps one can...
2024-05-3122 minThe mTOR You KnowGrowing Pains and Gains: Transplant Pharmacy FTE AcqusitionIn this episode of the mTOR You Know, Drs. Aileen Chi and Lauren Schumacher are joined by Drs. Ashley Feist and TrisAnn Rendulic to discuss their experience expanding their pharmacy teams. We encourage all listeners to read the previous publication "Considerations and approaches to expansion of solid organ transplant pharmacist services", published in JACCP in 2021, as it provides excellent guidance and background information. Tune in to this discussion to hear how our panelists have personally navigated some common challenges, their tips for making strong proposals, utilization of metrics and more!
2024-03-0549 min
NUTRIZIONISTA DR ORICCHIO GENNARO#023-2024 AMPK e mTOR: DUE PROTEINE IMPORTANTI CHE REGOLANO IL NOSTRO METABOLISMO#023-2024 AMPK e mTOR: DUE PROTEINE IMPORTANTI CHE REGOLANO IL NOSTRO METABOLISMO
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2024-02-2204 min
Fitness ConfidentialCaveat mTOR with Dr. Anthony Chaffee - Episode 2444Episode 2444 - On this Friday's show Vinnie Tortorich welcomes Dr. Anthony Chaffee and they discuss cholesterol, ketones, claims of caveat mTOR, and more. https://vinnietortorich.com/2024/02/caveat-mtor-dr-anthony-chaffee-episode-2444 PLEASE SUPPORT OUR SPONSORS Pure Vitamin Club Pure Coffee Club NSNG® Foods VILLA CAPPELLI EAT HAPPY KITCHEN YOU CAN WATCH THIS EPISODE ON YOUTUBE - @FitnessConfidential Podcast Ketones as Fuel NOTE: This episode is a load of information—grab a pen and paper, you may want to take notes! They open up chatting about the fitness of prominent low-carb doctors vs. vegan doctors. (2:00) Being lean and fit by eating right and staying active whi...
2024-02-021h 19
Master One Thing - Rapamycin Longevity SeriesJoan Mannick on Rapamycin Longevity Series | Turning down mTOR to young levels may be good for agingDr Joan Mannick is one of the world’s leading rapamycin and mTOR researchers in the longevity field. Joan has a background in academic medicine and is currently CEO at her own company Tornado Therapeutics where they focus on developing the next generation of mTOR inhibitors. One of the company goals is to create a mTOR inhibitor which is better than Rapamycin. Throughout the years Joan has made important discoveries in humans when it comes to finding a connection between mTOR inhibition and improvement of the aging immune system. In this podcast we are going to talk about her re...
2024-01-171h 22
Pushing The LimitsEnhancing Your Well-Being: "Autophagy, AMPK and mTOR Pathways" With Lisa TamatiThis week on "Pushing the Limits" join me on this journey through cellular pathways and longevity as I delve into the inner workings of cells and their impact on your overall well-being. We start by unraveling the AMP-activated protein kinase (AMPK) pathway, responsible for regulating metabolism and maintaining cellular balance. We explore how AMPK senses energy levels and its activation benefits for cellular health and energy conservation. We then compare AMPK with another key player, mTOR, and discuss their roles in cellular health and highlight the differences between these pathways and their contributions to longevity.
2023-12-0331 min
Inflammation Nation: Science Informed Wellness142 | Longevity and Healthspan (Part 4): mTOR, AMPK, Eating in Moderation, Having a Place and PurposeSend us a textEver wondered why some people live longer and healthier lives? Want to unlock the secrets of longevity? Our enlightening discussion aims to shed light on exactly that. We discuss the elephant in the room - inflammation, and its role in chronic diseases, how it affects our overall wellbeing, and strategies to control it. We also delve into lifestyle changes, emphasizing blood sugar control, hormone balance, gut health, and maintaining a healthy body mass for an improved quality of life. Plus, we discuss the molecular aspects of longevity, focusing on the role of mTOR...
2023-11-2825 min
Wild Health PodcastMTOR Unveiled Part 2: Protein, MTOR, and Muscle GrowthJoin Doctors Mike Mallin and Mike Stone as they delve into the science of muscle growth, protein synthesis, and MTOR. Discover how protein synthesis repairs and builds muscles, learn how to activate MTOR for optimal gains, and understand the difference between anabolic and catabolic processes. Get practical tips on maximizing fasting without muscle loss and explore the impact of protein intake on MTOR and longevity. Whether you're an athlete or fitness enthusiast, this episode provides essential knowledge to unlock your muscle-building potential. MTOR Unveild Part 1: https://wildhealth.libsyn.com/mtor-unveiled-part-1-the-key-to-cellular-growth-and-optimal-health
2023-08-2333 minWild Health PodcastMTOR Unveiled Part 1: The Key to Cellular Growth and Optimal HealthIn this highly anticipated episode, Doctors Mike Stone and Mike Mallin dive deep into the fascinating world of MTOR, an enzyme that serves as a crucial regulator of cellular processes. Join them as they demystify the intricate workings of MTOR and shed light on its impact on cellular growth, metabolism, protein synthesis, lipid production, and more. By delving into the intricate mechanisms at play, they help us understand how MTOR functions as the accelerator for growth and the key player in maintaining cellular homeostasis. Discover the importance of healthy MTOR activation and its correlation to disease prevention.
2023-08-0319 min
肿瘤界100s肿瘤界100s S1E43：探源mTOR（下）跟随肿瘤界，听点肿瘤学。大家好，这里是肿瘤界100s，我是主播李静。书接上回，我们继续mTOR的故事。直到90年代，人们首先在酵母菌中发现了雷帕霉素的靶点TOR。随后在哺乳动物中发现了与雷帕霉素的结合蛋白，由于其与酵母TOR基因有同源性，因此在TOR的前面加上了定语哺乳动物，最终定名为mTOR，m是英文哺乳动物mammal的首字母，即哺乳动物。那为什么mTOR还有个FRAP1的怪名呢？因为当时还有一款和雷帕霉素作用机制差不多的免疫抑制剂，叫做FK506，有人从大肠杆菌中筛选出了一款与FK506结合的蛋白质，起名FK506结合蛋白12（FK506-binding protein 12），进一步研究发现该蛋白质也能和雷帕霉素结合，就叫它FK506结合蛋白12-雷帕霉素相关蛋白1（FK506-binding protein 12-rapamycin-associated protein 1 ），名字是不是特别长，而且很拗口，它的缩写就是FRAP1，也就是mTOR。可见TOR基因确实是一个古老的基因，在酵母、细菌中都有存在，甚至在植物中也有重要的生长调节作用，到了哺乳动物中也并没有多大的改变。其实，FRAP1发现在前，mTOR发现在后，为什么mTOR称为正式称呼了呢？这还得感谢德语。在德语中，TOR的意思是“门”或“门户”，更能突出TOR的代谢调节功能。2009年，HUGO基因命名委员会正式将FRAP1基因名称更改为mTOR。现在已经明确，mTOR是PI3K相关激酶家族的一员，是细胞生长和增殖的重要调节因子。mTOR信号的过度激活会助长包括乳腺癌、前列腺癌、肺癌等多种肿瘤的发生和发展，抑制mTOR也在临床被证实有助于改善部分肿瘤患者的预后。基于mTOR调节多种细胞信号传导通路和代谢的作用，近年来学术界决定将mTOR的起始字母m的含义改为mechanistic，代表它具有调节细胞机制的功能，而不仅仅是雷帕霉素的一个靶点。mTOR的故事就到这里了，我是李静，感谢您的收听，我们下期见。
2023-08-0102 min
肿瘤界100s肿瘤界100s S1E42：探源mTOR（上）跟随肿瘤界，听点肿瘤学。大家好，这里是肿瘤界100s，我是主播李静。前两天我们在CAPItello研究那一期，提到了PI3K-AKT-mTOR通路，留了一个关于mTOR的小尾巴，那么今天我们一起mTOR通路的神秘面纱。mTOR抑制剂常作为HR+/HER2-的乳腺癌内分泌治疗的联合用药，也可用于晚期肾癌和部分神经内分泌肿瘤。单看mTOR（mammalian Target Of Rapamycin）这个名字有点让人一知半解，直译过来就是哺乳动物雷帕霉素靶蛋白，名字里还有一种抗真菌药物的名字，这是怎么回事？而且mTOR在有的文献里还被称为FRAP1，而且mTOR开头的m也有不同的含义，那么本期节目我们就来一一答疑解惑。故事还要从1960年代讲起，当时有人去复活节岛探险，这个与世隔绝的岛屿具备孕育天然抗生素的土壤。1972年，一位名叫Sehgal的学者从岛上土壤样本中的链霉菌内发现了一种小分子，将其纯化后证实这一分子具有抗真菌活性。Sehgal将这种抗真菌分子命名为雷帕霉素。因为复活节岛在本地语中叫做Rapa Nui，加上链霉菌的拉丁名Streptomyces，取后缀加上rapa，拼起来就是雷帕霉素。这也是我们的主角mTOR中雷帕霉素的由来。雷帕霉素除了抗真菌作用外，还被发现有免疫抑制和抗细胞增殖的作用。雷帕霉素在1980年代受到制药行业的极大兴趣，FDA曾批准雷帕霉素作为肾移植后的免疫抑制剂，但当时并不清楚雷帕霉素的作用机制。时间所限，本期100s就到这里了，我是李静，感谢您的收听，我们下期继续谈谈关于mTOR的故事。
2023-08-0102 minThe mTOR You KnowPGY1 -> PGY2 Couch Session Part 1On this couch session of the mTOR you know podcast incoming PGY-2 SOT residents Drs Bona Shin, Courtney Urzen, and Alisia Chen discuss their experiences during PGY-1 and how they developed an interest for transplant.
2023-06-1524 min
OncotargetGPR141 Regulates Breast Cancer Progression via Oncogenic Mediators and the p-mTOR/p53 AxisA new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, “G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis.”
Breast cancer morbidity is surging towards the peak in females across the globe. An inherent property of cancer cells is enhanced cell proliferation rate and migration capability, leading to deregulated cell signaling cascades. G-protein-coupled receptors (GPCRs) have recently emerged as a hot-spot target in cancer research.
Researchers Monalisa Parija, Amit K. Adhya and Sandip K. Mishra from the Institute of Life Sciences, Regional Centre for Biotechnology and All India Institute of Medi...
2023-05-2203 min
The Modern Vital PodcastUnlock Your Longevity: Mastering the mTOR Pathway for Optimal Health and Age-Defying FitnessIn this episode of The Modern Vital Podcast, the focus is on the mTOR pathway, a crucial protein complex responsible for regulating cell growth, metabolism, and survival in response to various environmental signals. The discussion highlights that mTOR is both activated and inhibited by exercise and plays a key role in extending our lifespan and health span. The pathway is involved in various diseases, such as cancer, metabolic disorders like type 2 diabetes, and neurological disorders.The connection between insulin resistance and mTOR is explored, with the idea that mTOR activity can be modulated...
2023-05-0912 minThe mTOR You KnowThe mTOR You Know Craft Beer Hoppy HourOn this episode, we take a step away from our regularly scheduled programming to talk about something near and dear to our hearts and taste buds: craft beer! Hosts John Lyons and Bona Shin discuss all things craft beer with Lindsey Toman, Barrett Crowther, and Steve Gabardi. There's guaranteed to be something for everyone: not only does the panel discuss the nuances of the styles they're enjoying at the moment, but they provide tips for a great brewery experience for those who are just scratching the surface of the craft beer world!
Please help...
2023-05-0859 min
Longevity by DesignDr. Joan Mannick—mTOR's Role in AgingDuring this episode of Longevity by Design, Dr. Joan Mannick explains how mTOR influences the aging process. She explains that this evolutionarily conserved protein is involved in several cellular functions in the body and acts on longevity-promoting pathways like autophagy. Dr. Mannick also discusses the connection between mTOR and the immune system, sharing her research on how low-dose mTOR inhibitors can upregulate antiviral immunity, creating an opportunity for more targeted vaccines for older adults. After extensive research on mTOR across many species, Dr. Mannick shares impressive insight into how mTOR inhibitors like rapamycin can promote longevity. Tune in to...
2023-02-2242 min
vlmd roundsCaveats on mTOR! | Episode 21Send us a Text Message. Caveats on mTOR!Time to talk about cell growth, so let's bring out the "massTOR" cell growth system, mTOR! Yes, it's important if you want to build bigger muscles and yes, it would help if you took your leucine but there's more involved with mTOR than meets the eye. Here are some details that are often not discussed when talking about mTOR and if you stick with it to the end, I'll even throw in cholesterol and statins (why not?) ***Note: when I say Rag ATPases, I mean ...
2023-02-071h 04The mTOR You KnowTxPharm v. Pharma - SOT Clinical TrialIn the latest edition of the mTOR You Know, Drs. Aileen Chi and Lauren Schumacher are joined by Drs. Rita Alloway and Simon Tremblay to litigate SOT clinical trials and its data. Giving you an exclusive behind-the-scenes look at how the highest court, the FDA, came down to its rulings and how to navigate the process.
2022-11-2157 minThe mTOR You KnowBeyond the Jab: Vaccination Considerations in Solid Organ TransplantIn the latest edition of the mTOR You Know, Drs. Hannah Naguib and Thomas Wert are joined by Dr. Dominic Chan to pull back the curtain and take a deep dive into all things vaccination in SOT and the balancing act our immunosuppressed patients face with regards to vaccine-preventable disease. Do you think vaccines are just a jab? Think again.
2022-10-0146 min
The Mastered MindsetEpisode 81 - A STRAIGHT FIRE CONVERSATION (Special Guests Mtor Apparel) //The Mastered MindsetLiterally couldn't put a title on this, we had Cameron and Pat, the owners of Mtor Apparel in and lets just say we hit some serious levels and touched on so many valuable topics.
Don't miss this one!
This episode is brought to you by our amazing sponsors Mtor Apparel https://mtorapparel.com.au/ Newy Design Co. https://studio.newydesignco.com.au/shop/ Sunnyholt Off Grid Touring https://sunnyholtoffgridtouring.com.au/
2022-07-281h 17The mTOR You KnowPediatric Transplant - Bridging DisparitiesIn this episode of the mTOR You Know Podcast, Evelyn Hsu, MD and Mary Moss Chandran, PharmD discuss the multi-dimensional disparities faced by pediatric transplant patients. They share the current landscape in pediatric transplant, discuss the effects of disparities in the continuum of care, assess the unmet need, and detail potential strategies to bridge disparities. They share important information about how transplant pharmacists can collaborate with physicians and get involved! This episode was hosted by Dr. Aileen Chi and Emily Sartain.
2022-07-1848 min
The Wellness Messiah PodcastDavid Sinclair on Best Diets for Longevity | Study Explained | Different Foods' Impact on mTORTo increase your longevity and defend yourself against aging,
you need your diet to be spot on.
You need the specifics.
You must feel certain about what to eat and how much - In the surest way from the 100 years of metabolic research.
And there is nothing surer in longevity than mTOR, a genetic pathway that controls longevity.
Because it extends 30% of lifespan in all animal forms.
But how does each food affect this longevity pathway?
How much should you eat?
Today, we’ll see Dr. Dav...
2022-07-0116 min
The mTOR You KnowWhat's Next?On the latest edition of the "mTOR You Know Couch Sessions" John Lyons and Alicia Lichvar are joined by guest host Lauren Schumacher and our wonderful panel of Aoife Iaria, Emily Garcia, Heather Johnson, and Idris Yakubu to discuss the winding and anxiety-ridden road to match day, the aftermath of the match, as well as the PGY2 job hunt for that first position. It's all about the journey, not the destination, right? We'll see what's about to happen next.
2022-06-2154 minDr. Jockers Functional NutritionmTOR, Polyphenols and Using Olive Oil to Fight Cancer with Dr. Limor GorenToday's episode is proudly sponsored by Paleovalley Organic Supergreens, a delicious blend of 23 organic superfoods to energize your body! Paleovalley Organic Supergreens uses only the finest, most bioavailable superfoods helping your body absorb those valuable vitamins, minerals, antioxidants, and enzymes found in each delicious serving. Paleovalley Organic Supergreens is a certified organic, gut-friendly, and nutrient-rich drink you and your kids are sure to love! Hurry and grab yours from Paleovalley.com and be sure to use code JOCKERS at checkout for an extra 15% off! BIG NEWS! Dr. Jockers just released his BRAND NEW book on...
2022-06-2142 min
Aging-USTestimonial: Dennis Mangan from MTOR LLCDennis Mangan from MTOR LLC in Bakersfield, California describes his experience publishing his theory article, “Iron: an underrated factor in aging,” in Volume 13, Issue 19 of Aging (Aging-US).
DOI - https://doi.org/10.18632/aging.203612
Corresponding author - Dennis Mangan - pdmangan@outlook.com
Abstract
Iron is an essential element for virtually all living organisms, but its reactivity also makes it potentially harmful. Iron accumulates with aging, and is associated with many age-related diseases; it also shortens the lifespans of several model organisms. Blocking iron absorption through drugs or natural products extends lifespan. Many life-extending interventions, such as rapamycin, calorie restriction, and old...
2022-03-1701 minThe mTOR You KnowRoid You Rather - Steroid Continuation vs WithdrawalOn this episode of the mTOR You Know podcast Drs Katie McMurry and Alicia Lichvar discuss the pros and cons of steroid continuation and withdrawal in kidney transplantation. This episode was hosted by Drs. Thomas Wert and Melissa Durst. References: PMID: 18936569, 33533901, 16378069, 31680394, 26816011
2022-02-2847 min
Movimento Estensione VitaSCIENZA - mTOR, il percorso metabolico controllato dalla Rapamicina e come questo influenza l'invecchiamentoMTOR, il percorso metabolico controllato dalla Rapamicina e come questo influenza l'invecchiamento
L'mTOR e' uno dei percorsi metabolici piu' importanti; ne abbiamo visti altri come l'AMPKinasi o come quello controllato dalle Sirtuine.
MTOR sta per "Mammalian Target Of Rapamycin", cioe' il percorso metabolico che nei mammiferi e' l'obiettivo della Rapamicina; quindi questo tipo di percorso metabolico e' strettamente collegato ad una sostanza importantissima nel mondo antiage che e' la Rapamicina, appunto.
L'mTOR e' molto importante ed e' coinvolto con la crescita e lo sviluppo dell'organismo; entra il gioco quando si nasce e quando...
2022-01-0319 minThe mTOR You KnowGhosts of Midyear Past, or Looking to the Future?Happy holidays from the mTOR You Know crew! For the first of the "Couch Sessions" series, Drs. John Lyons and Alicia Lichvar are joined by Drs. Stacy Bernard, Sara Bova, Brenda Astorga, and Reed Hall to swap stories of Midyear experiences, residency recruitment, suspect fashion choices (sorry Rita!), and everything "this American transplant pharmacist life" during the holiday season. Make sure to cozy up and have your heated blanket and hot cocoa on deck, because this is one packed podcast for a long winter's eve!
2022-01-011h 07The mTOR You KnowAdherence: The New Vital Sign - Part 1On this two part episode of the mTOR You Know Podcast, NPC members Helen Sweiss and Megan Galle chat with medication adherence experts Tiffany Kaiser, Holly Mansell, and Dave Taber.
2021-11-2324 min
Modern HealthspanmTOR in Aging Ep6 - Life interventions Dr Sabatini Interview Series Ep 6In this video Dr. Sabatini discusses some of the life style interventions that affect our longevity and his personal regimen. This is the last episode of Dr. Sabatani Interview Series.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex...
2021-08-0909 min
Modern HealthspanmTOR in Aging Ep5 - Diet & mTOR Dr Sabatini Interview SeriesDr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research.
He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
In this video Dr. Sabatini discusses how diet effects mTOR activation. He also talks about calorie restriction and intermittent fasting.
Some key refere...
2021-08-0114 min
Modern HealthspanmTOR in Aging Ep4 - Rapamycin and Rapalogs Dr David Sabatini Interview SeriesIn this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1 and mTORC2 and the rapalogs, drugs which are similar to rapamycin but may be more clinically effective.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator...
2021-07-1108 min
Modern HealthspanmTOR in Aging Ep 3 - Mitochondria Effects on mTOR Study Dr David Sabatini Interview SeriesIn this video Dr. Sabatini discusses his recent paper and in particular how the health of the mitochondria impact the activation of mTOR and how this is signaled.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our me...
2021-07-0406 min
Modern HealthspanmTOR in Aging Ep2 - How mTOR Impacts Lifespan Dr David Sabatini Interview SeriesDr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism In this video Dr. Sabatini discusses how mTOR impacts lifespan and whether its actions change with age
Some key references.
Twenty-five years of mTOR: Unc...
2021-06-2809 min
Modern HealthspanmTOR in Aging Ep1 - The Role of mTOR Dr David Sabatini Interview SeriesIn this video Dr. Sabatini discusses the role of mTOR as the master regulator of the cell and distinguishes between mTORC1 and mTORC2.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
2021-06-1311 min
MasmusculoLA IMPORTANCIA DE LA VÍA mTOR PARA LA HIPERTOFIA MUSCULAREn este segundo video del seminario impartido por Roberto Castellano continúa explicando cómo se produce la hipertrofia muscular y se centra en este caso en la vía MTOR y AMPK.
El término mTOR seguramente sea algo que mucha gente, aun siendo aficionada al deporte y al mundo del fisicoculturismo, no haya escuchado o leído hasta este momento. La vía mTOR es una vía metabólica empleada por nuestro organismo para la síntesis de proteínas en las células presentes en nuestros músculos y, gracias a ello, generar la hipertrofia muscular debido a la...
2020-12-1708 min
Health Psychology and Human Nature#48: mTOR, Aging and Longevity – Professor David SabatiniHow do we sense if we have eaten or not and how is that linked to how long an organism lives? In today’s interesting episode David tells us about the mechanistic target of rapamycin, mTOR for short. Professor David Sabatini is a member of the Whitehead Institute at MIT and perhaps more importantly the person who discovered mTOR. Friends I really hope you will enjoy today's Episode.
2020-11-1044 minThe mTOR You KnowNo Paper Left BehindFor the latest edition of the mTOR You Know, we are excited to present the research roundtable, a crossover between the ACCP IMTR PRN New Practitioner Council and Research Committee. Our hosts, John Lyons and Alicia Lichvar (our incoming IMTR PRN Chair!) discuss the challenges, trials, tribulations, and joys of transplant pharmacy research with a star-studded cast of Drs. Rita Alloway, Jillian Fose, Mei Jorgensen, and Katie McMurry. This roundtable discussion is not one you want to miss!
2020-11-0653 min
María Laura García presenta A Tu SaludLas Proteínas Antivejez AMPK y mTOR.Conversé en mi espacio radial, con el Dr. Juan Carlos Méndez (@doctorantivejez), Especialista en Medicina Antienvejecimiento sobre Las Proteínas Antivejez #AMPK y #mTOR.
Cuando hablamos de metabolismo, de reacciones bioquímicas que suceden en el organismo, discernimos dos procesos metabólicos antagónicos, pero íntimamente relacionados: catabolismo y anabolismo.
El catabolismo hace referencia a la degradación de grasa, glucógeno y tejido muscular para la obtención de energía. En cambio, el anabolismo hace referencia a la creación de tejido. La ruta enzimática AMPK induce la degradación de tejido, mientr...
2020-10-0706 min
Origins CastMTOR/GluconeogenesisWhy MTOR genes are there, and also why we do not have energy problems or adrenal fatigue with using protein into glycogen stores.
2020-09-0920 minThe mTOR You KnowCh- Ch- Changes!For our second episode of The mTOR You Know, we are joined by new practitioner members Dr. Amanda Condon-Martinez and Dr. Laura Cotiguala, along with (former) PGY2 members Dr. Kimberly Goehring and Dr. Lauren Schumacher for a roundtable discussion about the job search process, the transition from PGY2 to New Practitioner, as well as tips and tricks for starting new transplant pharmacy services.
2020-07-131h 27
The Peter Attia DriveLloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of agingLloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company's clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter's perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction. We discuss: His background and decision to leave academia for translational medicine [6:15]; Translational medicine—bridging the gap between basic science and clinical medic...
2020-07-062h 14
Brains and Gains with Dr. David MaconiDr. Brad Schoenfeld on Blood Flow Restriction, mTOR, Future ResearchBrad Schoenfeld, PhD, CSCS,*D, CSPS,*D, NSCA-CPT,*D, FNSCA, is internationally regarded as one of the foremost authorities on muscle hypertrophy. The 2011 National Strength and Conditioning Association (NSCA) Personal Trainer of the Year is a lifetime drug-free bodybuilder who has won multiple natural bodybuilding titles. As a personal trainer, he has worked with numerous elite-level physique athletes, including many top pros.Schoenfeld is an associate professor of exercise science at Lehman College in the Bronx, New York, and is director of the graduate program in human performance and fitness. He also serves as a sports nutrition...
2020-06-1243 min
The Melanie Avalon Biohacking Podcast#037 - James Clement: The Switch, Super Centenarians, Autophagy, Antioxidants, Fasting Vs. Feeding, AMPK vs. MTOR, Hacking Aging, And More!GET TRANSCRIPT AND FULL SHOWNOTES: MelanieAvalon.com/TheSwitch2:00 - Instagram Giveaway: Follow @MelanieAvalon And Comment Your Favorite Biohack To Enter To Win A Signed Copy Of The Switch!2:25 - IF Biohackers: Intermittent Fasting + Real Foods + Life (Melanie Avalon)3:40 - FOOD SENSE GUIDE: Get Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To...
2020-04-162h 06The mTOR You KnowThe mTOR You Know - IntroductionThe mTOR you know is an immunology/transplant podcast produced by the ACCP IMTR PRN New Practitioner Council. Please follow @themTORyouknow on twitter!
2020-03-1301 min
Siim Land Podcast#158 Sarcopenia, Autophagy and mTOR Lecture Two by Siim LandThis episode talks about sarcopenia, autophagy and mTOR. It's from my Biohacking Bootcamp.
Timestamps:
What Is Age-Related Muscle Loss or Sarcopenia 01:00
Squaring the Curve of Lifespan 05:20
Why Resistance Training is the Best Form of Exercise 10:30
Importance of Getting Enough Protein 14:41
Best Exercise for Muscle Growth 21:48
The Role of mTOR in Longevity 26:38
Is IGF-1 Good or Bad 34:33
Do You Need More or Less Autophagy 37:00
Ketosis and Carb Cycling 41:25
Metabolic Autophagy Food Pyramid 49:43
Microdosing Gluten for Hormesis 58:55
What Kind of Supplements Should You Take 01:03:00
Siim's Regular Diet Plan 01:07:10
And much more...
Here are the links to the podcast on all platforms
Link...
2020-01-211h 16
Paul Saladino MD podcast29. Will eating an animal based diet over-activate mTOR? With James ClementJames W. Clement is a lawyer and entrepreneur turned research scientist who has devoted the last two decades to understanding the science of life extension. He is best known for his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School and has received international press coverage. Through worldwide scientific collaborations and in his own laboratory, James focuses on advancing cutting-edge biomedical discoveries. He is the founder of the nonprofit Betterhumans biomedical research organization. Led by a collection of high-profile researchers, the organization focuses on bringing cutting edge scientific discoveries from the lab...
2020-01-141h 59
The Melanie Avalon Biohacking Podcast#021 - Siim Land: Autophagy, Metabolism, Protein Intakes,What Breaks A Fast, Anabolism And Catabolism, MTOR, Ketogenic Diets, Exercise, NMN, And More!Full Shownotes And Transcript: Melanieavalon.com/autophagy1:45 - LISTEN ON HIMALAYA!: Follow The Melanie Avalon Podcast In Himalaya For Early Access 24 Hours In Advance! You Can Also Join Melanie's Exclusive Community For Exclusive Monthly Content, Episode Discussion, And Guest Requests!01:55 - IF Biohackers: Intermittent Fasting + Real Foods + Life (Melanie Avalon): Join Melanie's Facebook Group To Discuss And Learn About All Things Biohacking! All Conversations Welcome!03:00 - BEAUTY COUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At Beautycounter.com/MelanieAvalon For Something Magical! For Exclusive Offers...
2019-12-261h 20
PhysionicEnergy State, AMPK, and mTORIn this brief episode, Alec explains the nuance for understanding the interplay between AMPK and mTOR within the cell.
YouTube: bit.ly/2JUjXVt
Facebook: bit.ly/2PlIOaB
Instagram: bit.ly/2OBFe7i
Email List: bit.ly/2AXIzK6
Patreon: bit.ly/2OBBna0
2019-08-2801 min
Y.E.S. Fitness "Longevity" PodcastY.E.S. Fitness "Longevity" Podcast Episode 53 - Autophagy and mTORWelcome back to the Y.E.S. Fitness "Longevity" Podcast Episode 53. Autophagy and mTOR are two hot topics in the longevity and nutrition world. What are they? How do they affect longevity? What foods lower mTOR, increase Autophagy and can affect your longevity?
If you need help putting together a well balanced program call me at Y.E.S. Fitness 860-673-4293. We offer remote coaching. https://www.yesfitnessct.com/remote-coaching
If you like this podcast, click below for additional episodes: https://www.yesfitnessct.com/y-e-s-fitness-longevity-podcast-home-page
2019-08-2323 min
Siim Land Podcast#113 Appetite, Insulin, Leptin, and mTOR with Omar Mohtar MD PhDYou might have heard conflicting opinions about what causes obesity and overeating. Part of it is blamed on calories, part of it on satiety signaling through this hormone called leptin. However, there is so much more context to how these pathways take effect.
Welcome to the Body Mind Empowerment Podcast I’m your host Siim Land and our guest today is Omar Mohtar. Omar is an MD PhD student at the Boston University in Molecular Medicine. He’s published papers on treating lung cancer, cell disease, leptin, and mTOR.
Timestamps:
How Omar Started Researching Leptin 01:30
How Does mTOR Affect Satiety 04:00
Cont...
2019-04-131h 09
Siim Land Podcast#105 Does Exercise Stop Autophagy Because of mTOR Q&AYou might have heard of protein accelerating aging and giving you disease because of this thing called mTOR
You might have also heard about the amazing health benefits of this thing called autophagy from fasting
Both of them are critical components of longevity and health so the key is to find a balance between the two
This episode of the Body Mind Empowerment Podcast is another Q&A on my YouTube live stream about mTOR, exercise, and mTOR
Timestamps:
Confusion About mTOR and Aging 00:55
Does Exercise Stop Autophagy 04:50
Does mTOR Increase Risk of Cancer 11:16
Fasted Training and Muscle Growth 13:30
Best...
2019-03-0453 min
The Keto Savage PodcastSiim Land dives deep into metabolism MTOR, and longevity!In this episode, I speak with repeat guest Siim Land and we dive deep into metabolism, MTOR, and longevity! Siim goes into detail about the benefits of being in a catabolic state and how to incorporate fasting. We flesh out MTOR and how it can be leveraged to build more muscle. We jump into the metabolic flexibility debate and how epigenetics could be a factor. Siim gives us his opinion on sauna use and cold therapy. We discuss the pros and cons of building muscle with carbs vs on a Keto diet. This was a great conversation and I...
2019-03-011h 00
Savage Perspective PodcastSiim Land dives deep into metabolism MTOR, and longevity!In this episode, I speak with repeat guest Siim Land and we dive deep into metabolism, MTOR, and longevity! Siim goes into detail about the benefits of being in a catabolic state and how to incorporate fasting. We flesh out MTOR and how it can be leveraged to build more muscle. We jump into the metabolic flexibility debate and how epigenetics could be a factor. Siim gives us his opinion on sauna use and cold therapy. We discuss the pros and cons of building muscle with carbs vs on a Keto diet. This was a great conversation and I...
2019-03-011h 00
Siim Land Podcast#73 Balancing Autophagy and mTOR - Biohacker Summit Tallinn 2018Life consists of anabolic and catabolic processes that are governed through many fuel sensors inside your body. The main pathways that direct anabolism and catabolism are mTOR, autophagy, and AMPK.
This is my speech about balancing anabolism and catabolism with mTOR and autophagy at the Biohacker Summit Tallinn 2018.
Here are the links to the podcast on all platforms
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If you want to support this podcast, then I'd greatly appreciate if you could join my Patreon community. You'll be able to...
2018-09-1732 min
Siim Land Podcast#72 IGF-1, mTOR, Autophagy Deep DiveYou must've heard that eating protein, meat, and dairy gives you heart disease and gives you cancer.
Does elevating IGF-1 and mTOR accelerate aging or do low levels of IGF-1 actually make you more prone to neurodegeneration and shorter life?
Is it better to bulk up fast with carbs or do it slowly on keto?
Does bulletproof coffee stop autophagy?
How many carbs to eat on the targeted ketogenic diet?
These are some of the few questions of this Body Mind Empowerment podcast. I’m your host Siim Land and we’re gonna have another Q & A episode.
This time I deci...
2018-09-1454 min
STEMTalks Archive - IHMC | Institute for Human & Machine CognitionEpisode 70: David Sabatini on the discovery of mTOR and its role in disease, longevity & healthspanPeter Attia, who was our very first guest on STEM-Talk, describes David Sabatini’s discovery of mTOR as one of his two favorite science stories.
Today, Dr. David Sabatini joins us and gives us a first-hand account of how his research into rapamycin in 1994 as a graduate student led him to the discovery of mTOR, which we now know is a critical regulator of cellular growth.
Our interview with David delves into his continuing research into mTOR, which has led to promising opportunities for the development of new treatments for debilitating diseases such as cancer, di...
2018-08-141h 16STEM-TalkEpisode 70: David Sabatini on the discovery of mTOR and its role in disease, longevity & healthspanPeter Attia, who was our very first guest on STEM-Talk, describes David Sabatini’s discovery of mTOR as one of his two favorite science stories.
Today, Dr. David Sabatini joins us and gives us a first-hand account of how his research into rapamycin in 1994 as a graduate student led him to the discovery of mTOR, which we now know is a critical regulator of cellular growth.
Our interview with David delves into his continuing research into mTOR, which has led to promising opportunities for the development of new treatments for debilitating diseases such as cancer, di...
2018-08-141h 16
The Peter Attia DriveDavid Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?In this episode, my good friend David Sabatini delves into his extensive work with the mechanistic target of rapamycin—better known as mTOR—and rapamycin. The compound rapamycin is the only known pharmacological agent to extend lifespan all the way from yeast to mammals—across a billion years of evolution. David, a professor of biology and a member of the Whitehead Institute at MIT, shares his remarkable journey and discovery of mTOR in mammalian cells and its central role in nutrient sensing and longevity. Fasting, rapamycin, mTOR, autophagy, gedankenexperiments: having this conversation with David is like being the proverbial kid in...
2018-08-131h 11STEM-TalkEpisode 62: Keith Baar talks about muscle and explains mTOR, PGC-1a, dystrophin, and the benefits of chocolateToday’s episode is the first of a two-part interview with Dr. Keith Baar, the head of the Functional Molecular Biology Laboratory in the Department of Neurobiology, Physiology, and Behavior at the University of California, Davis.
In his capacity as a researcher, Keith has made fundamental discoveries on how muscle grows bigger, stronger, and more fatigue resistant. He is a renowned scientist in the emerging field of molecular exercise physiology, and is leading a team of researchers attempting to develop ways to improve muscle, tendon and ligament function.
Part one of our interview features our co...
2018-04-241h 03
AudioHelicaseWhitehead’s David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and diseaseAs a graduate student, Whitehead Member David Sabatini identified mTOR, the keystone molecule in a cellular pathway connecting nutrition, metabolism, and aging. In this episode, he discusses how the molecule was first discovered and what his lab is currently working on, including mTOR’s role in cancer, growth, and metabolism.
2017-09-1210 min
'Under The Bar'mTOR Part 1 with Luke Tulloch - Episode 54 of Under The Bar PodcastResident neuroscientist Luke Tulloch aka 'Grounds Keeper Willie' is back in studio to break down the latest study on the role of mTOR pathway on building muscle - in Part 1 we explore the role of growth factors and energy status in optimising mTOR.... Also in this episode the boys answer the first Speak Pipe question on the topic of meal timing and they discuss highlights from the recent Christian Maurice Elemental Certification - big show!
Evil Genius Down Under Online is now live!
This is 5.5 hours of US sports performance expert Broderick Chavez letting loose at his Brisbane seminar presented...
2016-12-261h 09
Sigma Nutrition RadioSNR #123: Donald Layman, PhD - Leucine Kinetics, mTOR Activation & the Anabolic Response to ProteinEpisode 123: Donald Layman PhD, professor emeritus at the University of Illinois, discusses the "leucine threshold" and activation of the mTOR pathway, amino acid oxidation and why MPS drops 2-3 hours after that peaking even when protein remains being fed. Dr. Layman is professor emeritus at the University of Illinois. Dr. Layman's laboratory is working to define protein and amino acid requirements and the interrelationship between dietary protein and carbohydrates in adult health. His research is focused on the impact of diet and exercise on adult health problems of obesity, type 2 diabetes and the Metabolic Syndrome.
2016-05-3145 min
On Your Mind Neuroscience PodcastOYM 53: Everyone's doing mTORThis week on the On Your Mind neuroscience podcast:
We're talking about spooky science, gene patents and science idols! Then we break down the relationship between mTOR and the Huntington protein.
For links to what we talked about, full show notes and more, head to onyourmind.ca/everyones-doing-mtor
2014-11-0500 min
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 15/19Zielgerichtete Inhibition des Akt-mTOR-Signalweges unter Hitzeschock und Doxorubicin-Behandlungen in humanen Sarkomzellen in vitroSarkome stellen eine heterogene Gruppe von mesenchymalen Tumoren mit einem teilweise aggressiven klinischen Verlauf dar. Die biomedizinische Forschung untersucht molekulare Mechanismen, um durch eine gezielte Pharmaka-Modulierung die Effizienz klassischer Behandlungsmethoden zu steigern. Ein vielversprechendes therapeutisches Verfahren basiert auf der Anwendung der Hyperthermie in Kombination mit einer Standardchemotherapie. Die biologischen Auswirkungen der Hyperthermie auf intrazelluläre Prozesse, wie z.B. Signaltransduktionskaskaden, Reparaturmechanismen und Apoptosewege sind bislang nur teilweise erforscht.
In der Arbeit wurde die Auswirkung eines Hitzeschocks auf den anti-apoptotischen Akt-mTOR-Signaltransduktionsweg und dessen Bedeutung für die Vitalität der mit Hitze- oder Thermo-Chemotherapie behandelten Krebszellen in vitro untersucht.
Anhand der in...
2013-07-0300 min
Medizin - Open Access LMU - Teil 21/22Development of a Sensitive Phospho-p70 S6 Kinase ELISA to Quantify mTOR Proliferation Signal InhibitionBackground: Drug blood levels can only serve as a surrogate because of the lack of information on the drug's direct pharmacological effects in the individual patient. Measurement of the mammalian target of rapamycin (mTOR) activity dependent on the phosphorylation status of p70 S6 kinase (p70 S6K) offers a practical way for monitoring pharmacodynamic drug activity, with the potential to better assess the state of immunosuppression in individual patients. Material and Methods: Here, we established a novel in vitro model system by treating Jurkat cells and peripheral blood mononuclear cells with different concentrations of sirolimus after stimulation with phorbol 12-myristate 13...
2013-04-0100 minMedizin - Open Access LMU - Teil 20/22A phase I/II trial to evaluate the safety, feasibility and activity of salvage therapy consisting of the mTOR inhibitor Temsirolimus added to standard therapy of Rituximab and DHAP for the treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma - the STORM trialBackground: The current standard treatment of patients with relapsed or refractory diffuse large cell B-Cell lymphoma (DLBCL) primarily consists of intensified salvage therapy and, if the disease is chemo-sensitive, high dose therapy followed with autologous stem cell transplantation. In the rituximab era however, this treatment approach has shown only limited benefit. In particular, patients relapsing after rituximab-containing primary treatment have an adverse prognosis, especially if this occurs within the first year after therapy or if the disease is primarily refractory. Therefore there is an ultimate need for improved salvage treatment approaches. Methods/design: The STORM study is a prospective, multicentre...
2013-01-0100 minMedizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 14/19Gezielte molekulare Therapie des Mantelzell-Lymphoms In vitro Wirksamkeit von mTOR-Inhibitor RAD001 und PNP-Inhibitor Forodesin+dGUO in Mono- und KombinationstherapieDas Mantelzell-Lymphom ist ein aggressives B-NHL, das durch die Expression des Zell-zyklus-regulierenden Proteins Cyclin D1 charakterisiert ist. Diese Expression wird in den meisten Fällen durch eine chromosomale Translokation t(11;14)(q13;q32) ausgelöst.
Klinisch weist das MCL mit einem medianen Überleben von nur drei bis vier Jahren eine der schlechtesten Langzeitprognosen aller Lymphomsubtypen auf. In fortgeschrittenen Stadien kommt es zu frühzeitigen Rezidiven nach der Behandlung mit konventionellen Chemotherapeutika. Es besteht daher ein dringender Bedarf an neuen, effektiveren, mo-lekular ausgerichteten Therapieformen, die zu einer Verbesserung der Prognose und der Lebensqualität der Patienten führen.
In dieser Arbeit wurde hierfü...
2012-06-2100 minTierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 05/07Pharmacological studies of a novel inhibitor of the mammalian target of rapamycin (mTOR) signaling pathwayThe apoptotic mode of cell death (programmed cell death) is an active and defined process that plays an important role in the development of multicellular organisms and in the regulation and maintenance of cell populations in tissues under physiologic and pathologic conditions. Since dysregulation of apoptosis is associated with the progress of many diseases, induction of apoptosis is an interesting pharmacological target for the therapy of many diseases.
Our study shows that the novel semisynthetic pentacyclic triterpenoid C-KβBA has a profound antiproliferative effect on different tumor cell lines and that it induces apoptosis of tumor cells in vitro and v...
2010-07-2400 min