Shows
The Human 5.0 ProjectVO2 Max, Sleep Score & HRV Explained: What Your Wearable REALLY Predicts (2026 Guide)3 Wearable Metrics That Predict Longevity: VO2 Max + Sleep Score + HRV
Your smartwatch spits out three numbers that look “important”… but most people have no idea what they actually mean: VO₂ max, Sleep Score, and HRV.
In this episode, I break them down the adult way:
What each metric really measures
How accurate wearable estimates are (and where they fail)
What the science says they’re associated with long-term health outcomes
The simplest, highest-leverage ways to improve each one without obsessing
Key idea: these numbers are signals, not sentences. Learn to read the trend, adjust your training, and stop getting guilt-tri...
2026-02-0411 minThe Human 5.0 ProjectWhat Is Functional Medicine? Root-Cause Health Explained (No Hype, 2026 Guide)Functional medicine: legit tool or overhyped trend? In this 2026 guide, we explain what functional medicine is, its history, principles, strengths (root-cause fixes for chronic issues), and red flags (over-testing/supplementing, fear-based narratives). Learn how to use it smartly without getting played—start with basics like sleep/diet, demand measurable plans, and pick credible practitioners.
Cold Open
Intro + Disclaimer
What Is Functional Medicine?
What It Does Well
What It Isn't
Controversies & Pitfalls
How to Use It Pro
Close
Comment your FM experience! Subscribe for more biohacking truths.
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Fo...
2026-02-0310 minThe Human 5.0 ProjectPea Protein vs Whey (2026): Digestion, Leucine, Muscle Gain, and What to BuyWhey vs pea protein vs “natural” whole-food protein — what actually works for muscle gain, recovery, fat loss, and gut tolerance?
In this episode, we break down:
Why whey is still the gold standard (leucine + digestibility)
When pea protein wins (tolerance, acne/GI issues, plant-based)
Rice protein: the underrated option + why pea/rice blends work best
BCAAs vs full protein (when they matter, when they’re pointless)
Practical dosing: 3–5 meals/day, and why 40–45g per serving is a solid cap for most
Label red flags so you don’t ge...
2026-02-0310 minThe Human 5.0 ProjectDXA/DEXA Scan Explained: Visceral Fat, FFMI & ALMI (What Your Results Mean)You got a DXA scan and walked out with a sheet full of numbers… and zero context.
In this episode, I break down what DXA actually measures, why it beats BMI for real body composition tracking, and how to interpret the metrics that matter for performance + longevity—especially FFMI (Fat-Free Mass Index) and ALMI (Appendicular Lean Mass Index).
We’ll cover:
DXA vs BMI (why BMI misses muscle, bone, and fat distribution)
What DXA measures: lean mass, fat mass, bone mineral content
FFMI and ALMI: what they are, why they matter, and how to use them
Why visceral fat trend is a bigger...
2026-02-0311 minThe Human 5.0 ProjectUnlock Your Brain's Glymphatic System: Natural Detox for Better Sleep & Cognitive Longevity (2026 Guide)"Discover the glymphatic system—your brain's hidden detox pathway that clears toxins during sleep to boost focus, memory, and cognitive health. In this 2026 guide, we break down the science behind glymphatic flow, why it slows with age, and biohacks like optimized sleep positions, exercise, and magnesium to supercharge it. Learn how impaired glymphatic function links to Alzheimer's risk and how to protect your brain for longevity.
Intro to Glymphatic System
Science & Brain Detox Explained
Sleep: Your Nightly Power Wash
Advanced Biohacks Beyond Sleep
Your Glymphatic Longevity Toolkit
If you're into biohacking or neuroscience, hit like, subscribe for mo...
2026-02-0310 minThe Human 5.0 ProjectBiohacking Your Brain in 2026: Nootropics That Work + Neurofeedback Explained (Real Evidence, No Hype)Biohacking your brain in 2026 isn’t sci-fi—but most “cognitive superpower” marketing is still hype.
In this episode, we break down nootropics that actually have signal (caffeine + L-theanine, creatine, Lion’s Mane—pros/cons) and neurofeedback explained (what EEG brain training can realistically do, DIY vs clinical, and how to stack responsibly without frying your nervous system).
What we cover:
Superpower myth vs real optimization
High-signal nootropics (and red flags to avoid)
Neurofeedback basics + what to expect
DIY devices vs clinic training
A simple 14-day brain optimi...
2026-02-0213 minThe Human 5.0 ProjectMitochondria for Dummies: How Your Cells Make ATP (Energy) and ATP, Why You Feel Good or Bad! (VIDEO)If your energy crashes at 3 p.m., your brain feels foggy, and workouts feel like dragging a truck uphill… you might not need more motivation — you need better mitochondria.
In this episode of The Human 5.0 Project, we break down Mitochondria for Dummies: what mitochondria actually are, how they make ATP (your cell’s energy “cash”), why they get wrecked in the modern world, and the real levers that rebuild them — without the jargon or fluff.
What you’ll learn
✅ What mitochondria do (beyond “powerhouses”)
✅ The simple ATP factory explanation (food → electrons → “dam” → ATP)
✅ Why fatigue, cravings, brain fog...
2026-02-0110 minThe Human 5.0 ProjectMitochondria for Dummies (2026 Biohacker Edition): Make More Energy, Burn More Fat, Think Clearer(audio)If your energy crashes at 3 p.m., your brain feels foggy, and workouts feel like dragging a truck uphill… you might not need more motivation — you need better mitochondria.
In this episode of The Human 5.0 Project, we break down Mitochondria for Dummies: what mitochondria actually are, how they make ATP (your cell’s energy “cash”), why they get wrecked in the modern world, and the real levers that rebuild them — without the jargon or fluff.
What you’ll learn
✅ What mitochondria do (beyond “powerhouses”)
✅ The simple ATP factory explanation (food → electrons → “dam” → ATP)
✅ Why fatigue, cravings, brain fog...
2026-02-0110 minThe Human 5.0 ProjectHow to Test & Fix Insulin Resistance for Faster Fat Loss (2026 Guide)Part 2: Fix Insulin Resistance — Labs, Levers & Faster Fat Loss 2026
Insulin resistance is the silent brake on fat loss—especially stubborn belly fat—even when you're "doing everything right." In this Part 2 Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down how to test it properly (fasting insulin, HOMA-IR, A1C, glucose), what the numbers really mean, and the 6-lever reset that actually improves insulin sensitivity without crash diets.
In this episode:
What insulin resistance is and why it locks belly fat
Clean lab stack: fasting insulin, HOMA-IR, A1C, glucose, lipids
How to interpret results without panic (trends > single numbers...
2026-01-3110 minThe Human 5.0 ProjectStubborn Belly Fat: How to Lose It When Everything Else Is Lean (2026 Guide)Stubborn Belly Fat: Why It’s Last to Leave + The 7-Lever Fix (Steps, Sleep, Insulin, Training + BHB)
Stubborn belly fat is the last to go—even when your arms, legs, and face are leaning out. In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down why abdominal fat is physiologically protected (insulin, cortisol, alpha-2 receptors, low blood flow), and the exact playbook that usually unlocks it: calorie cycling, steps/NEAT, high-protein/fiber, sleep, training structure, alcohol control, and common traps.
In this episode:
Why belly fat is stubborn (biology + men vs women differences)
6-lever playbook: deficit audit, steps, protei...
2026-01-3011 minThe Human 5.0 ProjectHow to Stop Hair Loss: Evidence-Based Guide for Men & Women 2026 (No Hype)
Hair Loss Prevention 2026: Real Fixes for Men vs Women (Prescriptions, Supplements, Laser, Microneedling)
Hair loss affects 85% of men and 33% of women by age 50 — but it’s not inevitable. In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down the real causes (DHT patterns in men, diffuse/hormonal thinning in women), proven prevention measures, and what actually works without snake oil.
In this episode:
5 main types of hair loss (AGA, telogen effluvium, alopecia areata, traction, scarring)
Men vs. women: DHT-driven patterns vs. hormonal/nutrient triggers
Topicals: Minoxidil (men 5%, women 2–5%), ketoconazole shampoo, finasteride/anti-androgens
Supplements: Iron/ferritin (women priorit...
2026-01-3012 minThe Human 5.0 ProjectLL-37 Peptide: Immune Defense, Wound Healing & Stacking Risks 2026LL-37 Peptide: What It Does + Peptides It Works With (or Against):
LL-37 is your body’s master antimicrobial peptide—antibiotic, immune modulator, and wound-healing switch all in one. But it’s double-edged: powerful in infection/wound contexts, potentially inflammatory in auto-immune settings (psoriasis pathways, TLR activation).
In this Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down:
What LL-37 really is (mechanisms in plain English)
Where human evidence actually exists (topical wound trials)
Real risks (inflammation loops, quality control, context dependence)
Peptides & factors it synergizes with (defensins, innate ensemble)
What blunts or clashes with i...
2026-01-2908 minThe Human 5.0 ProjectIGF-1 LR3 Explained: Muscle Growth, Recovery & Injury Repair (Risks, Labs, “Stacks” Breakdown)IGF-1 LR3 isn’t a “recovery peptide” — it’s a growth signal that can change the game and bite back.
Tonight we separate hype from biology and break down the “Wolverine stack” like adults.
If GH peptides are the “pulse nudge,” IGF-1 LR3 is the downstream lever people chase for hypertrophy and recovery — a modified IGF-1 analog designed to drive stronger growth signaling by reducing binding to IGF binding proteins (IGFBPs).
And then the internet goes: “Cool… now stack it with PEG-MGF, TB-500, and BPC-157 and become Wolverine.”
Tonight we’re doing this like adults: mechanisms...
2026-01-2809 minThe Human 5.0 ProjectWho Should NEVER Use GH Peptides + Natural GH Boost Hacks 2026Part 2 of our GH secretagogue series: Who should NEVER touch Sermorelin, Ipamorelin, or CJC-1295 DAC—and how to get 60–80% of the same benefits naturally with sleep, protein timing, and training protocols. UltimateBiohacker10X covers real red flags (cancer history, diabetes, endocrine issues), long-term risks (glucose shifts, IGF-1 concerns), stop signals, and peptide-free levers that spike natural GH pulses without injections
Open: Flip Side of GH Peptides
Intro & Disclaimer
Who Should Avoid the GH Axis (Red Flags List)
Long-Term Risks & Monitoring
Natural Levers: Sleep Optimization (90% GH Pulses)
Protein Timing & Pre-Bed Protocol
Training for Natural GH Spikes (HIIT + Compounds)
When to C...
2026-01-2713 minThe Human 5.0 ProjectSermorelin + Ipamorelin + CJC-1295 DAC: Ultimate GH Stack Guide 2026Unlock natural GH pulses without synthetic HGH risks. In this 20-min Biohacker Briefing on The Human 5.0 Project, UltimateBiohacker10X breaks down the ultimate GH secretagogue stack: Sermorelin (GHRH nudge), Ipamorelin (clean selective pulse), and CJC-1295 DAC (extended elevation).
Get conservative 2025–2026 dosing, timing principles, what to expect (sleep, recovery, body comp), cycling rules, must-have labs (IGF-1 200–300 ng/mL target), stop signals, and real talk on grey-market quality & risks.
Peptides vs. Hype
Intro & Disclaimer
Big Picture: GH Pulses & Aging Decline
Dosing & Timing (Sermorelin 200–300 mcg nightly, Ipamorelin 100–300 mcg, CJC-1295 DAC 1–2 mg weekly)
What Users Report + Sides to Watch
Cycli...
2026-01-2707 minThe Human 5.0 ProjectNew Food Pyramid 2026: Eat Real Food & Stop the Metabolic Spiral (Biohacker Reset)The U.S. just flipped the food pyramid—protein first, ultra-processed dead last. In this 25-min drop, UltimateBiohacker10x breaks down the 2026 reset, why the old carb-base became a sickness engine, and how “eat real food” can stabilize energy, cravings, and glucose response in the real world. No fluff: a 7-day protocol, kid-proof tactics, and why this shift threatens the sick-care money machine.
"Eat real food” isn’t a slogan—it’s sabotage-proofing
Intro & disclaimer
Why the old pyramid broke us
The 2026 reset decoded
Why it works (energy stability)
CGM autonomy & your...
2026-01-1913 minThe Human 5.0 ProjectCreatine for Dummies (2026) – How Creatine Actually Boosts ATP, Strength & Brain EnergyCreatine explained for total beginners in 2026! In this quick "Creatine for Dummies" masterclass, Ultimatebiohacker10x breaks down exactly what creatine is, how the ATP-PCr reaction powers your muscles and brain, why phosphocreatine is your emergency energy buffer, real-world benefits (strength, power, focus, sleep debt recovery), best dosing (3g vs 10g+), myths busted (kidneys, bloating), and simple daily protocol.
Perfect if you're new to supplements, training hard, fighting brain fog, or just want more energy without the hype. No jargon overload — just clear science and practical tips.
Why Creatine Matters
What Is Creatine? (The Basics)
The ATP-PCr Re...
2026-01-1807 minThe Human 5.0 ProjectCreatine 2026 Masterclass: Brain, Muscle, Longevity Benefits, Best Dosing, Safety & How to Avoid Bloating (Ultimate Guide)Creatine isn't just for bodybuilders anymore — it's one of the most researched supplements for brain power, muscle growth, mood stability, and longevity in 2026. In this no-fluff masterclass, Ultimatebiohacker10x breaks down the science: history from meat extraction to Olympic gold, ATP buffering mechanism, real benefits (cognition under stress, women's cycle/menopause support, anti-inflammatory effects), optimal dosing (3g vs 10-20g strategies), kidney safety myths busted, bloating fixes, quality warnings (avoid cheap gummies!), and pro stacks like hot coffee + magnesium.
Intro & Why Creatine Matters
History & Discovery
ATP Buffer Mechanism
Benefits: Muscle, Brain, Women, Longevity (2026 Updates)
Dietary Sources & Sat...
2026-01-1716 minThe Human 5.0 ProjectSleep Optimization For Dummies Guide 2026: Crash Better, Wake Up Sharper (No-BS Tips)Sleep Optimization for Dummies 2026 — simple, no-fluff strategies to sleep deeper, wake up sharper, and perform better.
In this episode of The Human 5.0 Project, Ultimatebiohacker10x covers:
Wearables that actually help (Sleep Cycle, Fitbit, Oura, Whoop)
Diet tweaks for better sleep
Bedroom setup & lifestyle habits
Sleep hygiene do’s and don’ts
A simple starter plan for exhausted humans
Educational only — not medical advice.
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and...
2026-01-1406 minThe Human 5.0 ProjectSleep Optimization for Dummies 2026: Crash Better, Wake Up Sharper | No-BS Sleep Guide(audio)Sleep Optimization for Dummies 2026 — simple, no-fluff strategies to sleep deeper, wake up sharper, and perform better.
In this episode of The Human 5.0 Project, Ultimatebiohacker10x covers:
Wearables that actually help (Sleep Cycle, Fitbit, Oura, Whoop)
Diet tweaks for better sleep
Bedroom setup & lifestyle habits
Sleep hygiene do’s and don’ts
A simple starter plan for exhausted humans
Educational only — not medical advice.
🔥 Subscribe for no-BS biohacking & longevity drops
Follow on IG @Ultimatebiohacker10X
For more longevity insights and...
2026-01-1306 minThe Human 5.0 ProjectGLP-1 for Dummies: Ozempic, Wegovy, Mounjaro, Zepbound Explained (Ultimatebiohacker10x Blueprint)videoGLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound are everywhere — but most explanations are either fear-based, oversimplified, or shame-driven.
In this GLP-1 for Dummies (Ultimatebiohacker10x Edition) episode, we break it all down with high-performance clarity:
• What GLP-1 medications actually do
• Semaglutide vs tirzepatide — and why it matters
• Who these meds are (and are not) for
• Realistic fat-loss expectations
• Common side effects — and how to manage them
• How to start safely (without quitting in week two)
• How to protect muscle, metabolism, and energy
• What long-term use and maintenance really look like
2026-01-1309 minThe Human 5.0 ProjectGLP-1 for Dummies: Ozempic, Wegovy, Mounjaro, Zepbound Explained (Ultimatebiohacker10x Blueprint)audioGLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound are everywhere — but most explanations are either fear-based, oversimplified, or shame-driven.
In this GLP-1 for Dummies (Ultimatebiohacker10x Edition) episode, we break it all down with high-performance clarity:
• What GLP-1 medications actually do
• Semaglutide vs tirzepatide — and why it matters
• Who these meds are (and are not) for
• Realistic fat-loss expectations
• Common side effects — and how to manage them
• How to start safely (without quitting in week two)
• How to protect muscle, metabolism, and energy
• What long-term use and maintenance really look like
2026-01-1309 minThe Human 5.0 ProjectMUSE Cells 2026: The Endogenous Stem Cells That Could Replace Exosomes & MSCs Forever(audio)In this deep-dive episode of The Human 5.0 Project, Ultimate Biohacker 10X explores one of the most important — and least discussed — breakthroughs in regenerative medicine:
MUSE cells (Multilineage-Differentiating Stress-Enduring cells).
Discovered by Dr. Mari Dezawa in Japan, MUSE cells are a rare population of endogenous, non-tumorigenic, pluripotent-like stem cells already living inside the human body. Unlike traditional MSCs or exosome therapies that rely mainly on signaling and inflammation control, MUSE cells can home to injured tissue, integrate, and replace damaged cells — safely.
In this 2026 update, we cover:
The accidental discovery of MUSE cells...
2026-01-1207 minThe Human 5.0 ProjectMUSE Cells 2026: The Endogenous Stem Cells That Could Replace Exosomes & MSCs ForeverIn this deep-dive episode of The Human 5.0 Project, Ultimate Biohacker 10X explores one of the most important — and least discussed — breakthroughs in regenerative medicine:
MUSE cells (Multilineage-Differentiating Stress-Enduring cells).
Discovered by Dr. Mari Dezawa in Japan, MUSE cells are a rare population of endogenous, non-tumorigenic, pluripotent-like stem cells already living inside the human body. Unlike traditional MSCs or exosome therapies that rely mainly on signaling and inflammation control, MUSE cells can home to injured tissue, integrate, and replace damaged cells — safely.
In this 2026 update, we cover:
The accidental discovery of MUSE cells...
2026-01-1207 minThe Human 5.0 ProjectPeptides for Dummies 2026: Unlocking Healing, Immunity, and Vitality with KPV, BPC-157, and More!(audio)
In this episode of "Peptides for Dummies 2026," we explore the world of powerful peptides that support healing, boost immunity, and enhance overall vitality. Join Ultimate Biohacker 10X as we break down:
KPV: A tripeptide that reduces gut inflammation and supports immune health.
KLOW Peptide: A blend that promotes healing and reduces inflammation.
BPC-157: Known for its remarkable healing properties for muscles, tendons, and the gut.
TB-500 and TB-4: Peptides that enhance tissue repair and regeneration.
Thymosin Alpha-1: A peptide that boosts the immune system.
MOTS-c: A mitochondrial p...
2026-01-1206 minThe Human 5.0 ProjectPeptides for Dummies 2026 – A Comprehensive Guide to Healing Peptides
In this episode of "Peptides for Dummies 2026," we explore the world of powerful peptides that support healing, boost immunity, and enhance overall vitality. Join Ultimate Biohacker 10X as we break down:
KPV: A tripeptide that reduces gut inflammation and supports immune health.
KLOW Peptide: A blend that promotes healing and reduces inflammation.
BPC-157: Known for its remarkable healing properties for muscles, tendons, and the gut.
TB-500 and TB-4: Peptides that enhance tissue repair and regeneration.
Thymosin Alpha-1: A peptide that boosts the immune system.
MOTS-c: A mitochondrial p...
2026-01-1106 minThe Human 5.0 ProjectPEG-MGF 2026: Muscle Repair & Growth Peptide – Benefits, Research & Why It's Banned by WADA (Full Guide)PEG-MGF 2026: The pegylated version of Mechanical Growth Factor (MGF/IGF-1Ec) hyped for muscle repair, hypertrophy, recovery, and anti-aging—but banned worldwide in sports. In this morning episode of The Human 5.0 Project, Ultimate Biohacker 10X covers:
History & discovery (Goldspink's IGF-1 splice variant for damage response)
Why pegylation: Extends half-life from minutes to days for sustained benefits
Research: Strong preclinical (animal models) for muscle/bone repair; no large human RCTs
Functional medicine & biohacking use: Post-workout/injury stacks, site-specific dosing
Banned status: Explicitly prohibited on WADA 2026 List (S2 Growth Factors)
If you're chasing faster gains, injury recovery, or longevity mu...
2026-01-1006 minThe Human 5.0 ProjectNature Rewires Your Brain: Fractals, Focus & the 5-Minute Reset That Lowers Stress (Science-Backed 2026)Your brain wasn’t designed for screens, straight lines, and constant alerts.
It was designed for patterns.
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the neuroscience behind nature’s fractals — the repeating patterns found in trees, waves, clouds, and coastlines — and why they rapidly restore focus, reduce stress, and improve mental performance.
We explore:
Attention Restoration Theory (ART) — why modern life drains your brain
What “soft fascination” really means (and why it matters)
How mid-range fractals reduce cortisol, boost alpha brain waves, and improve he...
2026-01-1006 minThe Human 5.0 ProjectSNAP-8 Peptide 2026: Topical Anti-Wrinkle Breakthrough – Needle-Free Botox Alternative?Welcome to The Human 5.0 Project! In this episode, Ultimate Biohacker 10X dives into SNAP-8, the octapeptide that’s challenging Botox in 2026. We explore:
Origin & History: The journey from Argireline to SNAP-8.
Mechanism: How SNAP-8 works to relax expression lines topically.
Clinical Data: Efficacy and limitations in real-world studies.
Cosmetic & Biohacking Use: Topical applications, DIY stacks, and more.
Comparisons: SNAP-8 vs Argireline vs Botox.
If you're curious about non-injectable anti-aging solutions, this is your 2026 reality check!
Disclaimer: Educational content only; not medical advice. Always consult a de...
2026-01-1006 minThe Human 5.0 ProjectHair Regrowth 2026: Best Copper Peptides (GHK-Cu), Exosomes, Laser Caps vs LED – Ultimate GuideWelcome back to The Human 5.0 Project! On this episode, Ultimate Biohacker 10X breaks down the 2026 landscape for reversing androgenetic alopecia and waking dormant follicles. We cover:
GHK-Cu & AHK-Cu copper peptides: science, dosing, microneedling protocols & why they’re vascular game-changers
Exosomes + microneedling: early data, real risks, and whether they’re worth the price tag in 2026
Laser caps vs LED caps: why penetration beats scatter (the deep dive on coherence vs. coverage)
The modern understanding: hair loss isn’t just DHT anymore—it’s vascular dysfunction, inflammation, and dormant follicles
Full lifestyle & supplement playbook: blood flow boosters, DHT tamers, anti-inflammatories, and nutrie...
2026-01-1009 minThe Human 5.0 ProjectLiposomal Peptides 2026: Oral Breakthrough for BPC-157, GHK-Cu & More? Or Just FDA Workaround Hype? (No-BS Science Breakdown)Liposomal Peptides in 2026: Are oral liposomal formulations (BPC-157, GHK-Cu, epitalon & more) a game-changing way to get peptide benefits without injections... or just a clever marketing tactic to dodge FDA restrictions on compounded injectables?
In this no-hype episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks it down:
What liposomes actually are & why they're legit for approved drugs (Doxil, AmBisome, Onpattro)
The 2022 BioNanoScience review on liposomal methods: pros (protection, bioavailability), cons (heat instability, solvent residues, peptide degradation risks)
The real regulatory story: FDA's 2025–2026 crackdown on injectable peptides → clinics pivoting to "legal" oral/sublingual liposomals
The hard truth: Almo...
2026-01-0907 minThe Human 5.0 ProjectThe Lyophilized Exosome Lie: Why 2026's 'Shelf-Stable' Miracle Could Be a Dangerous GambleAre lyophilized exosomes the future of regenerative medicine—or a dangerous shortcut around science and regulation?
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down one of the most controversial claims in regenerative clinics today: that exosomes can be freeze-dried, stored at room temperature, reconstituted with saline, and safely injected.
We examine:
• What exosomes actually are (and why they’re fragile)
• What the human clinical evidence does—and doesn’t—support
• FDA warnings and real adverse event reports
• Why convenience claims often hide regulatory shortcuts
• The exact questions every pati...
2026-01-0909 minThe Human 5.0 ProjectExosome Therapy 2026: The Truth About Cellular Regeneration, Anti-Aging & Real Clinical Data (No Hype)Exosome Therapy 2026: The Next Frontier in Cellular Regeneration & Anti-Aging (But Is It Hype?)
Forget the "miracle cure" claims—let's break down the real science behind exosomes in 2026.
Hey biohackers, longevity rebels, and loyalists—this is Ultimate Biohacker 10X on The Human 5.0 Project. We're diving deep into exosome therapy: the cell-free alternative to stem cells that's exploding in regen medicine. But with massive hype, FDA warnings, and early clinical data, what's actually legit?
⚠️ Important Disclaimer: This is educational content only—not medical advice. No exosome products are FDA-approved for disease treatment as of 2026. Many clinic off...
2026-01-0908 minThe Human 5.0 ProjectSenolytics 2026: How to Clear “Zombie Cells” + The Real Human Data (No Hype)“Zombie cells” aren’t a meme—senescent cells accumulate with age, pump out inflammatory signals (SASP), and can sabotage joints, lungs, vessels, brain health, and recovery. In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real science of senolytics: where the concept came from, what senescent cells actually do, how senolytics work (and why dosing in trials is pulsed), and what the human evidence looks like so far.
We cover:
What senescent cells are + why they accumulate (Hayflick limit → modern aging biology) ScienceDirect
SASP: the inflammatory “broadcast” that damages nearby tissue...
2026-01-0908 minThe Human 5.0 ProjectThe War on Zombie Cells: Senolytics, Frailty, and Longevity—What’s Real in 2026(audio)“Zombie cells” aren’t a meme—senescent cells accumulate with age, pump out inflammatory signals (SASP), and can sabotage joints, lungs, vessels, brain health, and recovery. In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real science of senolytics: where the concept came from, what senescent cells actually do, how senolytics work (and why dosing in trials is pulsed), and what the human evidence looks like so far.
We cover:
What senescent cells are + why they accumulate (Hayflick limit → modern aging biology) ScienceDirect
SASP: the inflammatory “broadcast” that damages nearby tissue...
2026-01-0808 minThe Human 5.0 ProjectProbiotics vs Prebiotics 2026: End the Gut Confusion (What Works, What Doesn’t + 7-Day Reset)Everyone’s “fixing their gut” in 2026… and half the people are accidentally making it worse.
If you’ve ever said:
“I took a probiotic and got MORE bloated,”
this episode is for you.
Today on The Human 5.0 Project, we end the confusion for good:
✅ What probiotics actually are (and why CFU hype is misleading)
✅ What prebiotics are (and why they’re the missing piece)
✅ How probiotics + prebiotics work together (synbiotics)
✅ The real 2026 dose basics + why “more strains” can backfire
✅ Testing that actually helps vs. expensive graphs with no action plan
✅ Red flags (S...
2026-01-0809 minThe Human 5.0 ProjectTesamorelin (Egrifta) Explained 2026: Visceral Fat Reduction, IGF-1, Dosing Protocols & Longevity StacksTesamorelin (Egrifta / Egrifta SV) is one of the most discussed “longevity-adjacent” tools in 2026—because it targets visceral fat (the fat around organs that drives metabolic aging), while stimulating natural growth hormone pulses through the GHRH pathway.
In this episode, we go origin-to-clinic:
✅ What tesamorelin is (and why it’s different than straight HGH)
✅ The HIV lipodystrophy approval story + what the data actually showed
✅ Why longevity / functional medicine clinics are using it off-label in 2026
✅ Practical dosing ranges discussed in clinics, cycling strategies, and timing
✅ Popular combinations (fasting, peptides, glucose-support strategies)
✅ Who tends to benefit most—and...
2026-01-0707 minThe Human 5.0 ProjectOlive Oil 2026: The Only Fat You Need, Plus Avocado & Coconut Showdown – Real Science, No DogmaIn this episode, we dive deep into the science of healthy fats, focusing on olive oil, avocado oil, and coconut oil. Discover why these oils stand out, how they impact blood sugar and overall health, and which one might be best for you. Learn practical tips for incorporating them into your diet and what to look for when choosing quality oils.
Free Download: 3-Fat Cheat Sheet with meal-pair chart and dosage guide.
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if...
2026-01-0703 minThe Human 5.0 ProjectKPV Peptide 2026: The Anti-Inflammatory Powerhouse | Mechanisms, Dosing & Clinical InsightsWelcome to The Human 5.0 Project! In this episode, we dive into KPV, a groundbreaking tripeptide that’s making waves in the world of inflammation control. Discover its origins, the science behind its anti-inflammatory properties, and how it’s being explored in clinical and real-world settings. We’ll also explore dosing protocols and the latest findings from global research.
Disclaimer: This content is for educational purposes only and not medical advice. Always consult a healthcare professional before considering any peptide or experimental therapy.
Free Download: KPV Quick-Reference Card (Link in Description)
For mo...
2026-01-0610 minThe Human 5.0 ProjectWhy 97% of New-Year Diets Fail in 2026 — And the 4 Psychology Hacks That Actually Work (Science-Backed)From identity-based habits to dopamine rewiring, we’re diving into the real science of lasting weight loss in 2026.
What you’ll learn:
The shocking stats on why most diets fail within 19 days.
How to shift from “I want to lose 20 lbs” to “I’m the kind of person who…” and why that changes everything.
How to engineer your environment and rewire your brain’s reward system to make healthy choices automatic.
Why the 66-day habit rule beats perfection every time.
If you’re ready to ditch diet culture and build la...
2026-01-0605 minThe Human 5.0 ProjectMenopause 2026: The Real Blueprint for Hot Flashes, Belly Fat, Sleep & Hormones (No Hype)From strength training myths to fezolinetant (Veozah) and GH pathways — this is the full 2026 science-backed blueprint.
Today is the Menopause Biohacking Blueprint (2026) — the real, evidence-first playbook for hot flashes, sleep disruption, belly fat, mood swings, and brain fog. No fluff. No vendor ads. Just science — and a roadmap that actually works in the real world.
In this episode, we break down:
Why menopause isn’t “aging” — it’s a metabolic event (estrogen decline → insulin sensitivity shifts → visceral fat ↑ → muscle loss risk ↑)
The 3 non-negotiables for women 40+: muscle, insulin sensitivity, sleep
Time-restricted eating + t...
2026-01-0609 minThe Human 5.0 ProjectMitochondria 2026: Optimize Energy, Clear Senescent Cells & Add Healthy Decades (Science-Backed)Today we’re going deep on mitochondria (your cellular energy engines) and senolytics (tools being studied to clear “senescent” zombie cells that sabotage recovery, inflammation, and performance). No fluff. No vendor ads. Just PubMed-backed science and what the global research is actually pointing to in 2026.
In this episode, we break down:
What mitochondria are, what they do, and why they decline with age
The lifestyle levers that reliably boost mitochondrial function (training, sleep, fasting, heat/cold)
Mitochondria-targeted nutrition + supplements (NR/NMN, CoQ10, PQQ, urolithin A, spermidine, ALA/ALCAR, olive oil polyphenols)
2026-01-0509 minThe Human 5.0 ProjectDSIP Deep Dive: The “Sleep Peptide” Mystery—What PubMed Shows (Insomnia, Pain, Withdrawal, Safety)oday we’re diving into Delta Sleep-Inducing Peptide (DSIP) — the nonapeptide that’s been studied for decades in relation to sleep, stress physiology, pain, and even withdrawal states. And we’re doing this the right way: PubMed-backed facts only — no peptide-vendor hype.
In this episode:
Where DSIP came from (the 1970s origin story + sequence)
What human studies actually looked at (insomnia trials, mixed results)
Evidence for pain and withdrawal applications (older clinical literature)
Where DSIP shows up in the world’s medical literature (including DSIP-containing preparations like “Deltaran”)
The reality ch...
2026-01-0508 minThe Human 5.0 ProjectWinning the Longevity Race: Mindset Shifts & Sustainable Habits for 100+ Healthy Years (2026)Longevity isn't about chasing magic pills — it’s a race won through paradigm shifts, embracing discomfort, and sustainable habits. In this episode, Ultimate Biohacker 10X breaks down why food is medicine, why women should lift heavy (busting the "bulky" myth), how to reframe exercise and nutrition, and practical 2026 strategies for healthspan.
Key insights:
Food as drug: Quality fiber, protein, and polyphenols for microbiome and inflammation control.
Strength training myths: Women gain metabolism, bone density, and hormone balance — not bulk.
Embracing discomfort: Small stresses (cold, fasting, heavy lifts) build resilience.
Sustai...
2026-01-0506 minThe Human 5.0 ProjectThe Longevity Dilemma: Biohacking Hype vs Real Science (How to Trust But Verify in 2026)Welcome back to The Human 5.0 Project with Ultimate Biohacker 10X! In this episode of the Podcast, we dive into "The Longevity Dilemma: Navigating Biohacking Hype vs. Evidence-Based Science."
In a world buzzing with cutting-edge tech, peptides, and supplements, it’s easy to get lost in the hype. From miraculous claims of instant youth to peptides that promise to melt fat effortlessly, we’ll explore how to separate the real science from the marketing noise.
In this episode, you'll learn:
The psychology behind why we’re drawn to quick fixes and shortcuts.
Practic...
2026-01-0508 minThe Human 5.0 ProjectDihexa Explained (2026): The HGF/c-Met “Synapse Builder,” Animal Data, Cancer Concerns, and What Human Trials ShowTonight we’re breaking down Dihexa (PNB-0408) — the angiotensin IV analog that gets called “synapse-building on steroids.” People throw around claims like “stronger than BDNF” and “neurogenesis peptide,” but what’s real… and what’s internet mythology?
In this episode, we go raw + evidence-first:
What Dihexa actually is (and what it’s not)
The real mechanism: HGF / c-Met signaling and why that matters for synapses
What animal studies suggest (and where it doesn’t translate cleanly)
Oral activity + BBB penetration claims from early research
Why formulation/solubility is a headache (and why tha...
2026-01-0409 minThe Human 5.0 Project5-Amino-1MQ (5A1MQ) Part 2: Dosing Talk, Biomarkers to Track, and How to Spot Hype vs Real Data (2026)In Part 2 on 5-Amino-1MQ (5A1MQ), we get practical and responsible: how to think like a researcher, how to interpret viral before/afters without getting played, what biomarkers actually matter, and what “oral dosing” patterns are commonly claimed online as of 2026—with a clear reminder that this is not a standardized, published human dosing regimen.
This episode is NOT medical advice. 5-Amino-1MQ is a research compound and is not FDA-approved to treat or prevent any condition. If you suspect metabolic disease, celiac disease, or you’re on medications, talk to a qualified clinician.
In this...
2026-01-0410 minThe Human 5.0 Project5-Amino-1MQ (5A1MQ) Explained (2026 Update): NNMT Inhibitor, NAD+ Salvage, Fat-Loss Data, Muscle Aging & Safety—No HypeIs 5-Amino-1MQ (5A1MQ) the “fat-loss NAD+ compound” people claim—or is it just early-stage science getting overhyped? In this episode, JP (UltimateBiohacker10x / The Human 5.0 Project) breaks down what 5A1MQ actually is, how NNMT inhibition works, what the best animal data shows for obesity and fatty liver, what we’re seeing in aged muscle performance studies, and the most important part: what we still do NOT know in humans as of January 2026.
Key sources (for show notes):
NNMT inhibitor 5A1MQ cell/NAD+ findings (Neelakantan et al., 2017). PMC
DIO mouse obesity...
2026-01-0408 minThe Human 5.0 ProjectWhy You Can Eat Bread in Europe but Not in the US (Gluten, Flour Processing, Additives Explained)Welcome to The Human 5.0 Project with UltimateBioHacker10X.
Gluten has become the internet’s favorite scapegoat—but here’s the weird part: people who feel terrible after bread in the U.S. often report feeling totally fine eating bread in France, Italy, or Spain. Same person… different bread. So what’s really going on?
In this episode, we unpack:
Why US flour processing can be radically different (bleaching, enrichment, shelf-life priorities)
How long fermentation / sourdough-style methods may change digestibility
The role of additives & dough conditioners (and why ingredient lists matter)
2026-01-0406 minThe Human 5.0 ProjectSLU-PP-332 Side Effects (Part 2): Cardiomyopathy Rumors, Mouse Heart Data & What We Actually KnowWelcome back to The Human 5.0 Project with UltimateBioHacker10X
In Part 2 on SLU-PP-332, we skip the hype and talk side effects and the biggest online rumor: cardiomyopathy / heart risk. We break down what people commonly report anecdotally (like flushing, water retention, and fatigue when dosing too aggressively) and then zoom out to what preclinical mouse data can—and can’t—tell us about cardiac safety (histology, fibrosis signals, and functional echo-style outcomes).
Important: SLU-PP-332 is a preclinical research compound and is not approved for human use. This content is for education only and is not medica...
2026-01-0406 minThe Human 5.0 ProjectGH Peptides Explained: Ipamorelin, CJC-1295, Tesamorelin, IGF-1 & Why Most People Use Them WrongMost people chase growth hormone peptides without understanding how the pituitary actually works — and that’s how you end up with hormone shutdown, stalled gains, or long-term damage.
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down growth hormone–releasing peptides in plain English using a simple “phone call” analogy so you finally understand what these compounds actually do inside your body.
We cover:
• How Ipamorelin, Sermorelin, Tesamorelin & CJC-1295 stimulate your pituitary
• Why GH peptides are signals, not steroids
• The difference between GH release vs IGF-1 muscle growth
• How IGF-1 LR3 and...
2026-01-0304 minThe Human 5.0 ProjectPituitary Gland & HPA Axis Explained: Hormone Control, Stress, Growth & HealthspanYour pituitary gland and HPA axis control nearly every hormonal signal in your body — from stress and metabolism to growth, reproduction, and long-term healthspan.
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X delivers a clear, clinician-grade breakdown of how the pituitary gland actually works — without fluff or fear-mongering.
You’ll learn:
• The difference between the posterior and anterior pituitary
• How neural vs portal signaling controls hormone precision
• ADH and oxytocin — water balance, bonding, and mood
• Growth hormone, thyroid signaling, cortisol, and the HPA axis
• How chronic stress rewires hormone output...
2026-01-0309 minThe Human 5.0 ProjectThe Gut Microbiome Explained: How Your Gut Bacteria Control Health, Hormones & ImmunityThe Gut Microbiome Explained: Why Your Health Starts in Your Intestines
Your gut microbiome isn’t just about digestion — it’s a living ecosystem of over 38 trillion microorganisms that regulate nearly every system in your body. From hormones and immunity to inflammation, metabolism, and even mood, your gut bacteria quietly shape your health from the inside out.
In this episode, we take a deep dive into the intestinal microbiome (oral microbiome coming next) and break down what the science actually shows.
Inside this episode:
• When researchers discovered that gut bacteria outnumber...
2025-12-3106 minThe Human 5.0 ProjectMethylation Explained: Do You Need Methylated Vitamins? Testing, Gut Health & Optimal DosingMethylation Explained: Testing, MTHFR, Methylated Vitamins & the Gut-Brain Connection
Ever feel like low energy, mood swings, or brain fog is holding you back? It might be methylation – the body's core biochemical process for gene regulation, detox, and neurotransmitter balance. In this 12-minute episode, we break down what methylation is, how to test for deficiency (MTHFR & homocysteine), if testing even matters, why methylated vitamins (like methylfolate & methyl-B12) outperform regular forms for many, and the gut's surprising role (bacteria in yogurt don't methylate, but microbiome influences epigenetics via B vitamins & metabolites).
Key takeaways:
• Methy...
2025-12-3108 minThe Human 5.0 ProjectTop 10 Peptides of 2025: BPC-157, TB-500, Semaglutide & the Real Science Behind Modern Biohacking
The peptide revolution is here — and it’s changing how elite athletes, biohackers, and longevity clinicians approach healing, fat loss, and performance.
In this episode of The Human 5.0 Project, we break down the Top 10 Most Powerful Peptides of 2025, based on real-world use, clinical data, and years of hands-on experience — not hype.
You’ll learn what actually works, what’s overrated, and how advanced protocols are being used responsibly to optimize recovery, metabolism, and long-term health.
🔬 Covered in this episode:
• BPC-157 & TB-500 – The “Wolverine Stack” for tendon, ligament, and gut repair
• Semaglutide (Ozempic) –...
2025-12-3008 minThe Human 5.0 ProjectBrain Immune Cells Control Anxiety: How Hoxb8 Microglia Shape OCD, Stress & Mental Health (2025 StudyMicroglia Are Controlling Your Anxiety — The Brain’s Hidden Immune Switch
What if anxiety, OCD, and chronic stress aren’t just “mental” — but immune disorders of the brain?
In this episode of The Human 5.0 Project, we break down groundbreaking 2025 research revealing that microglia — the brain’s immune cells — act as biological “brakes” or “accelerators” for anxiety and compulsive behavior. When these cells malfunction, anxiety and obsessive behaviors can spiral out of control.
Drawing from landmark work by Nobel laureate Mario Capecchi, this episode explores how Hoxb8 microglia regulate emotional behavior — and how dysfunction in this syste...
2025-12-2909 minThe Human 5.0 ProjectHRT Explained: Why Hormone Therapy Was Wrongly Blamed — and What Women Need to Know Now (2025)FDA Removes HRT Black-Box Warning: The 20-Year Misinterpretation That Cost Millions of Women Their Health (2025 Update)
What if hundreds of thousands of women suffered needlessly for two decades because of a misinterpreted study?
For decades, women were told hormone therapy was dangerous — but the science never supported the fear. In this episode, we expose the truth behind the HRT scare, the FDA’s quiet reversal, and why modern hormone optimization is one of the most powerful tools for women’s health today.
Key takeaways:
• The WHI misinterpretation: Progestin arm risks were incorrec...
2025-12-2907 minThe Human 5.0 ProjectCRISPR for Immortality? The Science Behind Gene Editing and Human LongevityCould gene editing be the key to slowing — or even reversing — human aging? What if aging wasn't inevitable decline – but a manageable process we could rewrite? In this deep-dive episode, we explore The Promise of a Longer, Healthier Life through CRISPR gene editing – the revolutionary tool turning longevity from science fiction into scientific frontier.
Key highlights: • CRISPR basics: How it precisely snips and replaces genetic code linked to age-related diseases • Targeting the "Hallmarks of Aging": Senescent cells, mitochondrial dysfunction, telomere shortening • Top genetic targets: FOXO3, sirtuins, telomeres – the genes scientists are editing for extended healthspan • Healthspan vs. lifespan: Why healt...
2025-12-2906 minThe Human 5.0 ProjectPeptide Biology & Regenerative Medicine: The Functional Overview of Bioregulators (2025)Peptides are nature's signaling molecules – short amino acid chains that guide repair, regeneration, and resilience without overriding physiology. In this functional overview, we break down the most important biologically active peptides by length (dipeptides to decapeptides), focusing on Professor Vladimir Khavinson's groundbreaking Russian bioregulators and their real-world roles in longevity, immune balance, neuroprotection, and tissue repair.
Key highlights: • Dipeptides like Carnosine (antioxidant) and Vilon (immune/endothelial) • Tripeptides including GHK (collagen/wound healing) and Pinealon (brain protection) • Tetrapeptides: Epitalon (telomerase), Cartalax (cartilage), Prostamax (prostate) • Heptapeptides: Semax (BDNF boost) and Selank (anxiolytic) • Nonapeptides: Oxytocin & Vasopressin • Decapeptides: GnRH & Kisspeptin-10
We explore d...
2025-12-2906 minThe Human 5.0 ProjectJoint Regen 2.0: Why Nuts Aren’t Enough & What Actually Works After 40 (Peptides, Collagen, Cartilage Stack)Joint Regen 2.0: Why Eating Nuts & Seeds Won't Fix Your Cartilage After 40 (The Real Stack That Does)
Tired of joint stiffness, aches, and slow recovery creeping in after 40? You're not alone – but the viral "just eat more seeds" advice isn't the answer.
In this episode, we bust the myth that nuts and seeds alone can regenerate collagen and cartilage (spoiler: ALA omega-3 conversion is tiny, and human trials are basically nonexistent). Instead, we reveal the proven protocol clinics are using in 2025 to rebuild joints: collagen peptides, MSM, glucosamine/chondroitin, hyaluronic acid, and game-changing peptides BPC-157 + Cartalax....
2025-12-2906 minThe Human 5.0 ProjectApple Cider Vinegar EXPOSED: What Science Really Says About Weight Loss, Blood Sugar & Longevity (2025)Apple cider vinegar has been hyped as a miracle cure for weight loss, blood sugar control, and longevity — but what does the science actually say?
In this episode of The Human 5.0 Project, we break down the real research behind apple cider vinegar, including why recent high-profile studies were retracted, what benefits are real, and what’s pure internet myth.
You’ll learn:
• Why a major ACV weight-loss study was pulled
• What acetic acid really does in the body
• Whether ACV actually helps blood sugar or metabolism
• Why it won’t “boost metabolism” or ext...
2025-12-2904 minThe Human 5.0 ProjectGut Bacteria’s Secret Fuel: Trapping D-Lactate to Reverse Blood Sugar Spikes & Fatty Liver (2025 Breakthrough)Canadian researchers have uncovered a surprising new driver of metabolic disease — and it’s not sugar, fat, or calories.
In this episode of The Human 5.0 Project, we break down groundbreaking 2025 research revealing how D-lactate, a little-known byproduct of gut bacteria, may quietly drive insulin resistance, fatty liver disease, and metabolic dysfunction.
This isn’t hype — it’s a fundamental shift in how we understand metabolism.
In this episode, you’ll learn:
• How gut microbes produce D-lactate — a previously overlooked metabolic signal
• Why D-lactate disrupts glucose regulation and fuels fatty liver disease
• How researchers used...
2025-12-2904 minThe Human 5.0 ProjectEpitalon 2025: The Telomere-Extending Peptide That Could Add 10+ Years to Your Lifespan (Russian Longevity Secret)Epitalon (also known as Epithalon) is the synthetic tetrapeptide from Vladimir Khavinson’s Russian labs that’s making waves in 2025 for its potential to extend telomeres, optimize sleep, and promote healthy aging.
In this 12-minute episode, we’ll dive into:
The origin story: Khavinson’s 1980s discovery at the St. Petersburg Institute (correcting common misconceptions)
50+ years of research: Lifespan extension in animal models, human telomere findings, and 2025 trials on epigenetic aging
How it’s being used in longevity and functional medicine
Legal status: Approved in Russia/Ukraine, research-only elsewhere
St...
2025-12-2906 minThe Human 5.0 ProjectMindset Medicine: The Psychology Hack That Multiplies Your Healing, Focus & Biohacking Results (2025)What if your mindset is the missing variable sabotaging your results?
In this episode of The Human 5.0 Project, we break down Mindset Medicine — the science-backed mental frameworks that amplify the effectiveness of supplements, peptides, red light therapy, fasting, and other performance tools.
This isn’t motivational fluff.
It’s applied neurobiology.
You’ll learn how perception, expectation, and nervous-system regulation directly influence healing, cognition, and recovery — and how to harness them intentionally.
In this episode, we cover:
• Why mindset can amplify or block biological healing
• The neuroscience of placebo, expectation, a...
2025-12-2707 minThe Human 5.0 ProjectCerebrolysin 2025: The 60-Year-Old Brain-Regeneration Peptide Still Banned in the USA (Full Deep Dive)Cerebrolysin – the porcine-brain-derived peptide complex used in over 50 countries for stroke, TBI, dementia, Long COVID brain fog, and elite neuro-regeneration – but still not FDA-approved in the United States.
In this 15-minute masterclass, we cover:
1950s Soviet military origins & Professor Khavinson's revolution
60+ years of clinical data (hundreds of trials, millions of doses)
Exact mechanisms: 80% neurotrophic factors identical to human BDNF, NGF, IGF-1
Current 2025 protocols for TBI, stroke recovery, Long COVID cognition, anti-aging
Optimal dosing (5–30 ml), IM vs IV, best stacks (Pinealon, Semax, SS-31, Dihexa)
Why the FDA sa...
2025-12-2407 minThe Human 5.0 ProjectPinealon – The Russian Brain Bioregulator Restoring Neuroplasticity & Clearing Brain Fog (2025 Deep Dive)Pinealon is a Russian tri-peptide bioregulator developed for military brain resilience that’s now gaining global attention for neuroplasticity, brain fog, Long COVID cognition, and healthy aging in 2025.
Originally created by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Pinealon has over 40 years of research and real-world use behind it.
In this episode of The Human 5.0 Project, we break down:
• The full history of Pinealon from Soviet labs to modern clinics
• Decades of Russian research plus a 2024 Italian human pilot study
• How Pinealon supports BDNF, melatonin rhythm, EEG normaliz...
2025-12-2406 minThe Human 5.0 ProjectSemax & Selank (C-Max / C-Link): The Russian Brain Peptides Targeting Long COVID Brain Fog & Anxiety in 2025Semax and Selank (often labeled C-Max and C-Link) are Russian nootropic peptides dominating 2025 Long COVID, brain fog, and anxiety protocols.
Developed in Moscow over 30 years ago, these peptides are prescription medications in Russia but remain research-only in the United States.
In this episode of The Human 5.0 Project, we break down:
• The full history and 300+ Russian studies
• How Semax increases BDNF and neuroplasticity
• How Selank calms anxiety without sedation
• Why they’re being used in Long COVID and post-viral brain fog
• How they stack with Dihexa, Cerebrolysin, and Pinealon
• The global regulat...
2025-12-2306 minThe Human 5.0 ProjectSS-31 (Elamipretide) in 2025: The FDA-Approved Mitochondrial Repair Peptide Transforming Long COVID Fatigue and ME/CFS Recovery
SS-31 (Elamipretide) in 2025: The FDA-Approved Mitochondrial Reset for Long COVID and ME/CFS
Description:
Welcome back to The Human 5.0 Project! In this episode, we dive into SS-31 (Elamipretide) — the peptide that became the first FDA-approved mitochondrial repair therapy for a rare disease in 2025, and how it’s transforming our understanding of fatigue medicine.
In this episode, we cover:
Why SS-31 exploded in 2025 and the human data behind it
How SS-31 works inside mitochondria to restore energy production and reduce post-viral crashes
The exact labs that s...
2025-12-2208 minThe Human 5.0 ProjectTB-500 & Thymosin Beta-4 (TB4): The Legal Healing Stack Repairing Joints, Hair & Brain Fog (2025 Data)TB-500 + TB4: Rapid Joint Repair, Hair Growth Signals, and Brain Fog Improvements? What 2025 Data Shows
TB-500 and Thymosin Beta-4 (TB4) are peptides originally studied for tissue repair and immune signaling — and in 2025, they’re gaining attention for their potential roles in joint recovery, hair density support, and cognitive clarity.
In this episode of The Human 5.0 Project, we break down:
• What TB-500 and TB4 actually do at the cellular level
• 2025 human and pilot data on tendon healing, inflammation reduction, and neurovascular support
• Why athletes, clinicians, and biohackers are using these peptides as part of a repai...
2025-12-2205 minThe Human 5.0 ProjectLong COVID Brain Fog in 2025: Why It Happens, What Doctors Miss, and How to Fight BackIf you’ve had COVID and now feel like your brain is wrapped in cotton — words vanish mid-sentence, simple tasks feel overwhelming, and mental fatigue hits after just minutes — you’re not alone.
This is Long COVID brain fog, still affecting an estimated 10–20% of everyone infected since 2020 — over 100 million people worldwide.
In this deep-dive episode of The Human 5.0 Project, we break down what’s actually happening in the brain, why many standard evaluations miss it, and the 2025 clinical and functional medicine protocols that are helping people recover cognitive clarity.
In this episode, you’ll learn:
• The...
2025-12-2214 minThe Human 5.0 ProjectHashimoto’s Thyroiditis – The Truth They Don’t Put on the Bottle"Unveiling the Hidden Causes and Advanced Approaches for Better Thyroid Health"
In this episode of The Human 5.0 Project, we dive deep into Hashimoto’s thyroiditis, exploring the hidden causes that mainstream medicine often overlooks. Discover why T4-only therapy may not be enough, the importance of comprehensive lab testing, and cutting-edge strategies that are changing the way we approach thyroid health in 2025.
Key Points:
The hidden timeline of Hashimoto’s and why early immune markers matter.
Why standard treatments often fail and the role of T3 and desiccated thyroid.
Inno...
2025-12-2113 minThe Human 5.0 ProjectDepression or Thyroid Crash? 5 Lab Tests to Run BEFORE SSRIs (Biohacker 10X Reveals Hidden Pathways)Is depression really a “serotonin problem”… or something your doctor didn’t check?
In today’s episode, we’re breaking down the five real biological and lifestyle pathways that can mimic depression—and why SO many people get put on meds before anyone even runs basic labs.
As a retired MD who has seen countless rushed admissions and missed diagnoses, I’m pulling back the curtain on what depression often really is:
• Metabolic dysfunction
• Nutrient deficiencies
• Inflammatory brain stress
• Loneliness-driven cortisol overload
• Medication side effects
This deep dive gives you the exact roadmap to i...
2025-12-1010 minThe Human 5.0 ProjectMicroplastics: How They Invade Your Body, Damage Your Health, and How to Detox | Ultimate Biohacker 10X
Microplastics are now in our food, water, air—even our bloodstream. In this episode, we break down exactly where microplastics come from, how they enter the human body, the health risks they pose, and the emerging science on removing them.
We also cover:
• The top home and lifestyle sources of microplastics
• How to detox microplastics naturally
• What works, what doesn’t, and what’s emerging
• House and lifestyle upgrades to reduce plastic load
• How microplastics affect hormones, inflammation, mitochondria, fertility, and aging
• Biohacker strategies to protect your cells and extend your healths...
2025-12-1009 minThe Human 5.0 ProjectNAD+ Explained: NMN vs NR vs Niacin — The Ultimate Longevity Breakdown (2025)The Cellular Energy Masterclass: NAD+ Precursors for Peak Performance & Healthspan
In this deep-dive episode, we break down the full science behind NAD+, the molecule your mitochondria depend on for energy, repair, and metabolic resilience. We compare major NAD+ precursors—NMN, NR, Niacin, Niacinamide, NADH—and explain how each works, how they differ, and how to use them strategically for peak performance and extended healthspan.
🔥 What you’ll learn:
• What NAD+ actually does inside your cells
• Why NAD+ declines with age — and how to reverse it
• NMN vs NR vs Niacin vs NADH: Mechanisms & diff...
2025-12-1012 minThe Human 5.0 ProjectThe Ultimate GLP-1 And Incretin Showdown: Semaglutide, Tirzepatide, Retatrutide (+ Cagrilintide, Mazdutide, Survodutide)GLP-1 Showdown: Semaglutide vs Tirzepatide vs Retatrutide (+ Cagrilintide, Mazdutide, Survodutide) | Ultimate Biohacker 10X
In today’s episode of The Human 5.0 Project, we break down the ultimate incretin showdown — the real science behind the world’s most powerful metabolic and longevity drugs. Whether you're exploring Semaglutide, Tirzepatide, Retatrutide, CagriSema (Cagrilintide + Semaglutide), Mazdutide, or Survodutide, this episode gives you everything you need to understand which one fits your goals.
🔥 What You'll Learn:
• How GLP-1, GIP, glucagon, and amylin pathways really work
• Which compounds deliver the highest weight-loss percentages
• Longevity benefits: inflammation reduction, heart protection, metabolic reset...
2025-12-0906 minThe Human 5.0 ProjectNature vs. Pharma: Why Your Body Prefers Pathways Over Drugs | Ultimate Biohacker 10X ExplainsAre synthetic drugs silently overwhelming your body’s detox machinery?
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real difference between natural biological pathways and lab-created pharmaceuticals — and why your body reacts so differently to each one.
We dive deep into how the liver’s cytochrome P450 enzymes act as your internal garbage disposal system, processing hormones, toxins, plant compounds… and unfortunately, most pharmaceutical drugs. When these enzymes get overloaded, everything from hormone balance to detoxification to metabolic health starts breaking down.
Inside this episode you’ll learn:
🔥 Why pe...
2025-12-0810 minThe Human 5.0 ProjectSLU-PP-332: The Future of Exercise in a Pill!In this episode of The Human 5.0 Project, we dive deep into SLU-PP-332, a groundbreaking compound that promises to revolutionize metabolic health and longevity. Dosing in notes.
What You’ll Learn:
Origins and Development: Discover how SLU-PP-332 was developed at Saint Louis University and the brilliant minds behind it.
Mechanism of Action: Learn how this compound mimics exercise at the cellular level, boosting mitochondrial function and metabolic health.
Current Applications: Explore the therapeutic uses of SLU-PP-332 and how it compares to other metabolic therapies.
Dosing: Research dosing is oral capsule, 500 µg daily in one...
2025-12-0812 minThe Human 5.0 ProjectALS Unveiled: Navigating Supportive Therapies and Future InnovationsIn this episode of the Human 5.0 Project, we delve into the complex world of ALS (amyotrophic lateral sclerosis). We start with a brief overview of what ALS is, and then we explore the current standard treatments, including medications like Riluzole and Edaravone. The heart of the episode focuses on the innovative supportive therapies being used in the U.S.—from functional medicine and nutritional supplements to cutting-edge peptides and their role in supporting neuron health. We also look into the exciting research and future directions, including stem cell therapies and their potential to transform ALS care. Join us as we...
2025-12-0705 minThe Human 5.0 ProjectNicotine: The Truth Behind the ‘Addictive’ Label, COVID-19 Spike Proteins & The Science They Never Told YouIn this episode of The Human 5.0 Project, we unpack one of the most controversial molecules in modern medicine: nicotine.
Not smoking. Not vaping. Nicotine itself.
For decades, nicotine has been labeled as “highly addictive” by the FDA and Surgeon General—but emerging research from the 1990s through 2025 paints a far more complex picture. We dive into:
🔬 What the science actually shows: 1990s–2025
• Big Tobacco documents revealing how additives—not nicotine—supercharged dependence
• Why pure nicotine behaves differently from cigarette-delivered nicotine
• How NRT (patches, gum) shows almost zero abuse potential
• Neuroprotective effects in Alzheimer’s, Parkins...
2025-12-0714 minThe Human 5.0 ProjectThymosin Alpha-1 (TA1) in 2025: Dosing for Immunity, Autoimmune & Longevity + Best StacksWelcome back to The Human 5.0 Project! In today’s episode, we’re diving deep into Thymosin Alpha-1 (TA1)—the immune-modulating peptide that’s been quietly revolutionizing immune resilience for decades.
We cover:
The fascinating history of TA1: From its discovery in the 1970s to its role in 2025 as a trusted tool for biohackers and longevity enthusiasts.
How TA1 works: We break down how this 28-amino-acid peptide acts as the conductor of your immune system, fine-tuning T-cells, NK cells, and cytokines for a balanced, anti-inflammatory response.
Dosing protocols for everything from acute viral in...
2025-12-0707 minThe Human 5.0 ProjectSemaglutide Simplified: From Ozempic to Healthspan HeroIn this 9-minute episode, we break down Semaglutide (Ozempic/Wegovy/Rybelsus) — the GLP-1 agonist that reshaped weight loss, longevity, and metabolic health. Even as newer peptides like Tirzepatide and Retatrutide enter the spotlight, Semaglutide remains a proven, reliable, and highly effective tool for weight management and healthspan optimization.
We cover everything you need to know:
✔️ What Semaglutide is & how it works
✔️ Why it’s STILL relevant despite newer multi-agonists
✔️ Dosing protocols for weight loss & diabetes
✔️ Side effects & how to minimize them
✔️ The best stacks for muscle retention, longevity, & metabolic health
✔️ The 2025 biohacking trend: microdosin...
2025-12-0708 minThe Human 5.0 ProjectRetatrutide Revolution: The Triple-Threat Agonist Redefining Weight Loss & BeyondWelcome back to The Human 5.0 Project – where we upgrade the human operating system.
In today’s episode we go full-send on Retatrutide , Eli Lilly’s triple-agonist that just obliterated every weight-loss record in 2025: up to 24.2% body weight loss in 48 weeks (that’s 50–60+ lbs for most people) with simultaneous improvements in A1c, liver fat, blood pressure, and triglycerides. People are already calling it the “Ozempic killer” and the first true “programmable metabolism” molecule.
Here’s exactly what we cover in this 9-minute deep dive:
What Retatrutide actually is (GLP-1 + GIP + Glucagon triple action explained simply)
Why the gluc...
2025-12-0608 minThe Human 5.0 ProjectGHK-Cu Unleashed: Copper Peptide Magic for Skin, Healing, and BeyondIn this 5-minute deep dive, we unpack GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper), the copper-bound tripeptide that’s absolutely dominating 2025 longevity and aesthetic medicine conversations. Once a well-kept secret of high-end skincare, GHK-Cu is now the #1 most-researched regenerative peptide worldwide — and for good reason.
Here’s exactly what we cover:
Why natural GHK levels drop from ~200 ng/mL in your 20s to under 20 ng/mL by age 60… and how GHK-Cu reverses that decline
Injectable vs. topical: real-world differences in absorption, dosing, and results (including scar remodeling, wrinkle reduction, and hair regrowth data)
The 7 core mechanisms: gene modulation (4,000+ genes), collagen/elastin...
2025-12-0604 minThe Human 5.0 ProjectVilon Blueprint: How a Two-Amino Peptide Rewires ImmunityDive into the world of Vilon, one of the original Khavinson peptides, in this focused seven-minute breakdown. We cover what it does (Lys-Glu dipeptide from thymus extracts), how it works (chromatin remodeling, gene upregulation), and the exact research dosing protocols used in cell cultures and rodents. If you're into longevity, immunosenescence, or peptide stacks, this episode unpacks the science behind restoring youthful immune function. Like, subscribe, and comment your favorite bioregulator below!
For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.
And if yo...
2025-12-0607 minThe Human 5.0 ProjectCrohn’s and Inflammation: Navigating Holistic Treatment Paths.In this episode, we dive into holistic approaches to managing Crohn’s disease and related inflammation. From peptides and supplements to diet and lifestyle tweaks, discover how you can create a balanced, integrative plan for symptom relief without relying solely on heavy-duty medications. Always discuss treatment plans with your healthcare provider.
#CrohnsDisease #Inflammation #HolisticHealth #Peptides #DietAndLifestyle #GutHealth #AutoimmuneHealing
2025-12-0504 minThe Human 5.0 ProjectUnlocking Ipamorelin: The Peptide Path to Performance and LongevityIn this episode, we dive deep into the world of Ipamorelin, a powerful peptide known for boosting growth hormone levels, enhancing recovery, and supporting anti-aging. Whether you're curious about how it works, the benefits, or the potential drawbacks, we've got you covered in a quick seven-minute deep dive.
#Ipamorelin #Peptides #Biohacking #Longevity #HumanPerformance #Wellness #PodcastLife
2025-12-0506 minThe Human 5.0 ProjectMOTS-c Explained: The Tiny Peptide with Big Metabolic PowerIn this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down MOTS-c — a mitochondrial peptide that’s making waves in the longevity and metabolic health communities. Learn how this small but mighty peptide works, why researchers are excited about its potential benefits for metabolism, insulin sensitivity, and healthy aging, and what current research says about dosing and safety. Remember, MOTS-c is still in the experimental stage, so always consult a professional before exploring any new peptide protocols.
#MOTSc #Biohacking #Longevity #Mitochondria #Peptides #MetabolicHealth #HumanOptimization #UltimateBiohacker10X #TheHuman50Project #Wellness #HealthScience
2025-12-0407 minThe Human 5.0 ProjectBPC-157: What It Is, How It Works, Why It Matters and Current DosingBPC-157 is one of the most talked-about peptides in the biohacking, longevity, and performance science world — yet most people still don’t understand what it actually does or how it works. In this episode, I break down the real science behind BPC-157, separating hype from reality and giving you a clear understanding of its role in regeneration, recovery, and gut health.
We explore the origins of BPC-157, how it’s derived from a naturally occurring protective protein in the stomach, and why researchers have been fascinated by its effects on healing, inflammation, and tissue repair. You’ll learn ho...
2025-12-0114 minThe Human 5.0 ProjectKLOW Peptide Blend 2026: Ultimate Healing Stack for Gut, Skin & Recovery (GHK-Cu + BPC + TB-500 + KPV)The KLOW Peptide has become one of the most talked-about compounds in the optimization and performance world — but most people still have no idea what it actually does or how it fits into the KLOW framework. In this episode, I break down the science behind the KLOW Peptide, how it works, the pathways it influences, and why it’s gaining so much attention in the biohacking community.
You’ll learn how the KLOW Peptide interacts with the four pillars of the KLOW Protocol:
K — Ketosis
L — Low Insulin
O — Optimal Hormones
W — Weight Management & W...
2025-11-3014 min
Limitless MindsetTHE most MIND-BLOWING day of my life as a BiohackerThe relentless seeker of wisdom and knowledge is sometimes rewarded with a "Satori experience" - a powerfully transformative moment of TOTAL spiritual clarity about your life and what you are in the world to do. In the past I was skeptical of such things, but no longer because this happened to me this year. It was pretty mindblowing, and while I'm still processing it, I'm ready to talk about it. But in describing this I prefer to use the Greek word Anakainōsis, which means a renewal, renovation, or complete change for the better.ἀνακαίνωσιςI like this...
2024-06-0929 min
Health Optimisation Podcast with TimbiohackerDetox or Die - Why Modern Life Demands a New Health Strategy with Gary Brecka“There are some individual needs that every human being has. And if you can find that deficiency and put that raw material back into the human body, those people thrive in ways they never thought possible.” –Gary BreckaYou’re not just getting old. It’s not because your job is stressful or your kids are tiring you out. Your brain fog, weight gain, poor sleep, poor focus… They’re a sign that you're nutrient deficient.Gary Brecka says nutrient deficiencies are impacting our genetic function and our body’s ability to heal itself. The good news? This...
2024-04-241h 10
Health Optimisation Podcast with TimbiohackerDetox or Die - Why Modern Life Demands a New Health Strategy with Gary Brecka“There are some individual needs that every human being has. And if you can find that deficiency and put that raw material back into the human body, those people thrive in ways they never thought possible.” –Gary BreckaYou’re not just getting old. It’s not because your job is stressful or your kids are tiring you out. Your brain fog, weight gain, poor sleep, poor focus… They’re a sign that you're nutrient deficient.Gary Brecka says nutrient deficiencies are impacting our genetic function and our body’s ability to heal itself. The good news? This...
2024-04-241h 10
High Performance HealthBitesize Biohack: Banish SAD & Upgrade Your Energy in The Winter Months with Beth McDougall M.DAngela interviews Dr. Beth McDougal about the importance of mitochondrial health and its impact on overall well-being. They discuss various therapies and biohacking techniques that can optimise mitochondrial function, such as red light therapy and pulsed electromagnetic field therapies. Dr. McDougal explains how these treatments can improve energy production within cells, leading to better cellular health and overall vitality. KEY TAKEAWAYS Mitochondria are the energy powerhouses of our cells and play a crucial role in our overall health and well-being. Red light therapy can up-regulate mitochondrial function by unblocking enzymes and increasing energy production...
2023-11-1014 min
High Performance HealthBitesize Preview: Empowering Women through The Cycle Syncing Method®️ with Alisa VittiAngela presents a bitesize alongside Alissa Vitti, who discusses key nutrition tips and practices for promoting longevity and overall health, particularly for women over the age of 45. They look at the negative effects of alcohol on aging and disease risk, encouraging women to eliminate it from their diets, plus the importance of managing blood glucose levels is also highlighted, with the suggestion of wearing a continuous glucose monitor to understand individual metabolic responses to different foods KEY TAKEAWAYS Alcohol is not recommended for women over 45 due to its negative effects on aging a...
2023-11-0316 min
Young and Profiting with Hala Taha (Entrepreneurship, Sales, Marketing)Gary Brecka: I Can Predict How Long You Have Left to Live! 10X Your Health With These 3 No-Cost Bio Hacks | Health and Wellness E250For more than two decades, Gary Brecka worked in the life insurance business, using medical records and demographic data to predict life expectancy. One day he had an epiphany: there were human beings on the other sides of his spreadsheets and he wasn’t going to spend one more day of his own life predicting death. Instead, he would use his knowledge to help people live healthier, happier, and longer lives. Gary Brecka is now a biohacker, human biologist, and one of the world’s foremost experts on how thinking differently about nutrition can protect us against aging and dise...
2023-10-161h 02
High Performance HealthBitesize: Toxins, Detoxification and Women’s Health - with Dr Jill Carnahan Angela interviews Dr Jill Carnahan, who shares their personal journey of dealing with the impact of toxic chemicals on their health and highlights the alarming increase in the number of chemicals introduced into our environment each year, with little regulation or testing by authorities. KEY TAKEAWAYS The exposure to toxic chemicals, such as glyphosate, is a major contributor to modern illnesses, chronic conditions, autoimmunity, and cancer epidemics. The regulation and testing of chemicals in the environment, especially in the US, is inadequate, leading to the introduction of hundreds of thousands of new chemicals e...
2023-09-0113 min
High Performance HealthBitesize: Finding Your Authentic Self with Dr John Demartini In a preview of her upcoming interview with Dr John DeMartini, Angela and her very special guest discuss the power of authenticity and living in alignment with our highest values. Dr. Demartini believes that motivation is a symptom of not being authentic, and that when we are living in alignment with our values, our body and mind flourish. He also highlights the importance of exemplifying what we teach and finding joy in doing what we love. VALUABLE RESOURCES The power of our thoughts: The transcript emphasizes the belief that what we think about, we become...
2023-08-2509 min
High Performance HealthBitesize Biohack: Creatine - The Brain Boosting & Body Composition Hero Supplement For this special Bitesize Biohack, Angela explores the benefits of creatine for women's health. While traditionally associated with men and bodybuilders, creatine has numerous advantages for women, particularly during the menstrual cycle, perimenopause, and postmenopause. KEY TAKEAWAYS Creatine is a molecule that is important for producing ATP, the energy currency of the body. It is primarily made in the liver and is important for skeletal muscle health, bone density, gut health, and brain health. Women have less storage capacity for creatine compared to men, so supplementation can be beneficial for women. Taking 3-5 grams of creatine d...
2023-08-1814 min
High Performance HealthBitesize Biohack: Blood Glucose Control, Weight Loss and Polyphenols with Dr Clare BaileyAngela is joined by Dr Clare Bailey to talk about the benefits of olive oil and how to reduce your blood sugar in order to promote weight loss and help to reverse Type-2 diabetes. KEY TAKEAWAYS One you reach a state of ketosis, you're burning fat rather than sugar. Once you get your sugars down you will feel better and more alert. Take a piece of string and cut it to your height - fold it in half, wrap it around your middle, and the double string should meet at the end. This is an easy...
2023-08-1115 min
PROFUSION#38 Gary Brecka | Health Edition | Human Biologist, Biohacker, & Co-Founder of 10x Health SystemsGary is an human biologist, an entrepreneur, founder of Streamline Medical Group based in Naples, and Co-Founder of 10x health system. Fl. His goal is to support people so they can become their best, healthiest and living the most fulfilled lives. He has over 20 years of experience in “Bio-Hacking” and “Functional Medicine”—his passion lies in customizing peak performance protocols for individuals to achieve optimal health. He’s an expert on serum blood and genetic biomarkers.
Instagram: https://www.instagram.com/garybrecka/?hl=en
Website: https://10xhealthsystem.com/
2022-08-3057 min