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Oncology for the Inquisitive MindOncology for the Inquisitive MindFireside Chats 2. Time Toxicity in Early Phase TrialsFor patients with advanced cancer, early-phase trials may represent the last best hope of significant anticancer response. For clinicians, every early phase trial holds virtually unlimited promise and hope of becoming the next immunotherapy or hot antibody-drug conjugate. However, early-phase trials also come with significant uncertainty of efficacy, toxicity and even dosing.A recent Limbic article (link below) reported on an article published in ESMO Open that investigated the burden of "time toxicity" for patients enrolled in early-phase clinical trials, and advocated for this to be minimised. While it is essential to consider logistic factors and...2023-12-1222 minthe limbicthe limbicDr Anne Tonkin on what specialists need to know about CPD in 2023This January saw the roll out of the Medical Board of Australia’s updated CPD requirements – all registered doctors are now required to complete 50 hours of CPD annually – this includes preparing a professional development plan, and at least 25 hours spent on activities related to reviewing performance and measuring outcomes. Now four months into the program, Chair of the Medical Board of Australia, Dr Anne Tonkin speaks to the limbic about the changes – why they were introduced, how the 50 hours are broken down, what the professional development plan looks like and her thoughts on how the changes will impact clinicians.2023-04-2019 minthe limbicthe limbicCAR-T in the UK: What’s next2022-06-0629 minthe limbicthe limbicCAR-T in the UK: A unique roll outIn this first of two episodes, we speak to two leading UK haematologists, Dr Robin Sanderson (King’s College London) and Dr Caroline Besley (Bristol), about the innovative way in which CAR-T was introduced in the UK, the challenges that have been overcome, including the impact of Covid-19, and what they have learnt so far about using this highly personalised therapy.2022-06-0234 minthe limbicthe limbicPODCAST: GESA 21 conference wrap with Dr Thomas Tu and Dr Avik MajumdarIn this podcast senior researcher at the Westmead Institute for Medical Research, Dr Thomas Tu discusses the latest developments in hepatitis B presented at this year’s GESA scientific meeting - from new treatments under development that bring the promise of cure closer to public health viral elimination strategies. And Dr Avik Majumdar, transplant hepatologist at the Royal Prince Alfred Hospital in Sydney shares his highlights from the Liver stream discussing new data identifying sub groups and prognosis in decompensated cirrhosis, new treatment developments in  primary sclerosing cholangitis and liver disease and the increasing role of non-invasive evaluation on prognosis in...2021-09-2032 minthe limbicthe limbicFamilial Hypercholesterolaemia: what you need to know about the MBS listed genetic test and the latest treatment updatesAccess the guidelines in summary and in full here:Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physiciansIntegrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia in Australia    2021-09-0230 minthe limbicthe limbicMOGA 21 highlights: meet the YOGA research award winnersIn this MOGA 21 highlights episode Dr Christina Teng, winner of this year's YOGA oral abstract prize, discusses her work looking into just how long chemotherapy induced peripheral neuropathy (CIPN) persists that provides some fascinating insights that could help clinicians discuss the side effect with patients. We also speak to Dr Wei Hong, winner of this year's poster presentation, who discusses his latest work looking into a new approach to conducting oncology clinical trials that could save much needed time and money.2021-08-1215 minthe limbicthe limbicCSANZ 21 conference highlights with A/Prof James Chong and Prof Liza ThomasIn this podcast Associate Professor James Chong, scientific program chair, discusses the latest translational research discussed at this year’s scientific meeting – from new stem cell technologies that will reduce the need for heart transplantations to the clinical consequences of cardiac fibrosis and opportunities for treatment. Professor Liza Thomas, cardiac imaging stream lead, also shares her highlights discussing new data presented on myocardial function post COVID, the emerging field of cardio-oncology and the role of imaging in sub-clinical heart failure.2021-08-1221 minthe limbicthe limbicPODCAST: Tips to overcome diagnosing and treatment challenges in ANCA-associated vasculitisThis series is a collaboration with the Australian Rheumatology Association and the limbic. New episodes of season one will drop every week over the next four weeks, so be sure to follow the limbic podcast in your favourite podcast app so you don’t miss out. You can also visit us at the limbic to get all the latest rheumatology news delivered to your email. 2021-07-1635 minthe limbicthe limbicPODCAST: Vasculitis: tips to overcome challenges in diagnosing and treating Giant Cell ArteritisClinicians who treat vasculitis are familiar with uncertainty.  In its many forms, and with no single sign, symptom or investigation strong enough to confirm a diagnosis, vasculitis presents an extensive list of challenges in a setting where diagnostic delay can lead to devastating consequences. In episode three of our Rheumatology Advanced Trainee series we deep dive into two types of vasculitis -  giant cell arteritis (GCA) here in part 1 and ANCA-associated vasculitis next week in part 2. You'll hear Dr Tony Sammel and Dr Daman Langguth discuss what they’ve learned about how to diagnose the rare condition and how to best...2021-07-0837 minthe limbicthe limbicPODCAST: Flipping the fibromyalgia paradigm: how changing the way you think about chronic pain benefits patientsOn episode 2 of our podcast series for rheumatology advanced trainees we share a fascinating conversation on fibromyalgia with the inspiring Dr Sam Whittle, Dr Emma Guymer and Dr Richard Kwiatek. This series is a collaboration with the Australian Rheumatology Association and the limbic. New episodes of season one will  drop every week over the next four weeks, so be sure to follow the limbic podcast in your favourite podcast app so you don’t miss out. You can also visit us at the limbic to get all the latest rheumatology news delivered to your email. In this conversation you'll hear abo...2021-07-0140 minthe limbicthe limbicthe limbic podcast for Rheumatology Advanced Trainees: Ep01 BiologicsIn this episode Dr David Liew and Dr Tina Racunica discuss what you need to know about considering biologics in special populations particularly in patients with cancer, the new JAK inhibitors and where they fit in to treatment regimens, when to switch agents and how to balance clinical trial data among agents to make treatment decisions David Liew is a rheumatologist and clinical pharmacologist at Austin Health in Melbourne, and has an active interest in the quality use of medicines in rheumatology. Dr Tina Racunica is a rheumatologist and pharmacist. She is the director of her group private rheumatology practice...2021-06-2547 minthe limbicthe limbicHighlights from the ARA 2021 ConferenceIn this episode the limbic talks to Associate Professor Peter Wong, convenor of this years' scientific meeting, about the highlights from the hybrid event.2021-05-2718 minthe limbicthe limbicPodcast: Prof Paul Zimmet and the other pandemic: lessons from the war against diabetesProfessor Paul Zimmet believes that serendipity and chance have played a central role in his career. From reading an article on diabetes in a discarded Lancet during a cold London Christmas to finding himself sitting on a beach next to a director of the World Health Organisation, he’s embraced opportunities that arose from being in the right place at the right time. Lucky breaks aside, Professor Zimmet’s hard work and determination have undoubtedly led to his string of achievements in the world of diabetes and obesity. He founded the International Diabetes Institute and his epidemiological studies have predicted and...2021-05-1832 minthe limbicthe limbicHIGHLIGHTS FROM THE TSANZSRS 2021 CONFERENCETackling some of the biggest global challenges from respiratory health in the face of climate change to fighting big tobacco and COVID-19 as well as highlighting important developments in respiratory genetics and technology - this year's TSANZSRS conference covered a lot of ground. In this podcast the limbic talks to Professor Gary Anderson, Associate Professor Lucy Burr and Danny Brazzale about their highlights from the 2021 meeting.2021-05-0628 minthe limbicthe limbicFrontline stories: the toll of COVID-19 and the mental health of doctors in AustraliaThe largest survey of Australia’s healthcare workers has highlighted the sharp rise in mental health symptoms experienced by doctors and health care workers around the country throughout the COVID-19 pandemic. The Australian Frontline Healthcare Workers Study was distributed nationally in September last year at the height of Victoria’s COVID-19 second wave amid nearly four months of strict lockdown, receiving record responses. Over eight weeks close to 10,0000 healthcare workers participated in the survey speaking of burnout, feeling unsafe at work, and frustration with misplaced funding and inadequate quick fixes. Detailed stories from senior clinicians, junior doctors, allied health workers and...2021-04-1939 minthe limbicthe limbicA treatment for silicosis? Prof Dan Chambers on the procedure that could halt the deadly diseasehttps://onlinelibrary.wiley.com/doi/10.1111/resp.14018 2021-03-0421 minthe limbicthe limbicPODCAST: 'The Lost Tribe': The state of medical training in AustraliaYou can view the full survey results here:  https://www.medicaltrainingsurvey.gov.au/. 2021-03-0128 minthe limbicthe limbicDr Ranjana Srivastava on dying well and empathy in medicineOncologist, acclaimed author and journalist Dr Ranjana Srivastava talks to the limbic about the responsibility of practicing the art of empathy in medicine, negotiating difficult conversations and what she's learned from her patients over two decades about dying well. Ranjana Srivastava is an oncologist, award-winning author and columnist for The Guardian. She was awarded the Medal of the Order of Australia for her work on doctor-patient communication. Her book, Dying for a Chat: the communication breakdown between doctors and patients, won the 2013 human rights literature award.2021-02-1133 minthe limbicthe limbicTransitioning From Paediatric To Adult Care In Rheumatologyhttps://bmjopen.bmj.com/content/11/1/e039670.long 2021-02-0420 minthe limbicthe limbicWhat to expect in cardiology in 2021: An interview with Prof Clara ChowFrom the new 2021-02-0223 minthe limbicthe limbicPODCAST: Prof Bruce Thompson on what to expect in respiratory medicine in 2021A year into the coronavirus pandemic and now with a vaccine finally approved by the TGA for use in Australia we speak with TSANZ president Professor Bruce Thompson about vaccine rollout and how COVID-19 will continue to affect the field of respiratory medicine. We also talk about TSANZs controversial position on e-cigarettes, the devastating lung condition silicosis and how changing the language we use to talk about respiratory conditions could help make the biggest difference to patient outcomes in 2021.2021-01-2734 minthe limbicthe limbicPODCAST: What to expect in haematology 2021: An interview with Dr Leanne BerkahnFrom off-the-shelf CAR T-cell therapy products, and a big focus on drug-antibody conjugates and novel molecular compound trials to the search for new immunotherapy regimens we talk to HSANZ president Dr Leanne Berkahn about what 2021 will bring to the field of haematology.2021-01-1824 minStumble ThroughStumble ThroughProcrastination with Harry WallaceThis is not about productivity hacks! This is a fun episode where we talk less about how to do things in less time and with more attention, and more about why it’s so hard to, you know, do the thing.Harry Wallace is a writer, journalist, theatre maker, adventurer, student, and a self-proclaimed expert procrastinator. Procrastination is a multifaceted issue, and Harry beautifully fleshes out some of the more nitty gritty issues as we discuss the psychological phenomenon of procrastination, what drives it, the ramifications, and it’s place within both the human experience and society.2020-04-2043 minOperation Self Reset With Jake NawrockiOperation Self Reset With Jake NawrockiEmotional Decisions Explaned pt1But emotion is believed to be generated from a physical source, and the part of the brain responsible for it is thelimbic system of the brain, which is made up of several structures located in the cerebral cortex.2017-12-0640 min